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$400+ Cheap flights from Manchester, NH to Florence, SC (MHT - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/25. Fares are subject to change and may not be available on all flights or dates of travel.
MHT — FLO
May 24 — May 311
Sun 5/24
Sun 5/31
1 adult, Economy
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Cheap flight deals from Manchester to Florence

Cheapest flights from Manchester to Florence
Explore the most affordable flight options available from Manchester to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2026.

This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/224:40 pm
MHT
-
FLO
1 stop5h 07m
American Airlines
Tue 5/56:15 am
FLO
-
MHT
2 stops10h 41m
American Airlines
Deal found 4/21$604
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:00 am
MHT
-
FLO
2 stops9h 50m
American Airlines
Wed 4/294:16 pm
FLO
-
MHT
2 stops7h 28m
American Airlines
Deal found 4/21$609
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:40 pm
MHT
-
FLO
1 stop5h 07m
American Airlines
Tue 5/54:02 pm
FLO
-
MHT
2 stops7h 44m
American Airlines
Deal found 4/21$619
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:00 am
MHT
-
FLO
2 stops9h 50m
American Airlines
Mon 5/44:16 pm
FLO
-
MHT
2 stops7h 24m
American Airlines
Deal found 4/21$624
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:40 pm
MHT
-
FLO
1 stop5h 07m
American Airlines
Mon 5/44:16 pm
FLO
-
MHT
2 stops7h 24m
American Airlines
Deal found 4/21$634
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/266:00 am
MHT
-
FLO
2 stops9h 50m
American Airlines
Mon 5/44:16 pm
FLO
-
MHT
2 stops7h 28m
American Airlines
Deal found 4/21$639
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/266:00 am
MHT
-
FLO
2 stops9h 50m
American Airlines
Tue 5/56:15 am
FLO
-
MHT
1 stop7h 13m
American Airlines
Deal found 4/21$653
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/224:40 pm
MHT
-
FLO
1 stop5h 07m
American Airlines
Fri 5/15:20 am
FLO
-
MHT
2 stops30h 22m
American Airlines
Deal found 4/21$718
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:40 pm
MHT
-
FLO
1 stop5h 07m
American Airlines
Fri 5/15:20 am
FLO
-
MHT
2 stops30h 22m
American Airlines
Deal found 4/21$733

Find flight deals from Manchester to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Manchester (MHT) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$890
(American Airlines)

One-way from

$400
(American Airlines)

Popular in

July

Cheapest in

March

Average price

$615
Provider with most accurate pricing for Manchester-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Manchester-Florence flights.
Search Deals
From Manchester to Florence
Search Deals
One-way flight from Manchester to Florence
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($83 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Manchester to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
Use the filters below to find and compare flights from Manchester to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Mon 5/4

4:40 pm-9:47 pm

1 stop5h 07m

Florence

Fri 5/8

5:20 am-4:56 pm

2 stops11h 36m

$890
Cheapest one-way
Quickest one-way

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sat 7/25

7:00 am-9:44 pm

2 stops14h 44m

$400

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/21

Sorted by cheapest first

Compare providers for flights from Manchester to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Manchester to Florence in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Manchester, New Hampshire-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Manchester, New Hampshire-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Manchester, New Hampshire-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Manchester, New Hampshire-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Manchester, New Hampshire-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Manchester to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Manchester with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Manchester to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Manchester, New Hampshire to Florence, South Carolina?

    American Airlines can get you from Manchester, New Hampshire to Florence, South Carolina in just under 5h 07m. Your travel time can differ by up to . Manchester, New Hampshire and Florence, South Carolina are separated by a distance of 751 mi.

  • Can I find deals for flights from Manchester to Florence that include hotel bookings?

    Yes. In addition to deals on Manchester to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Manchester to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Manchester to Florence.

  • Can I find deals for business class flights from Manchester to Florence?

    Yes. Cheapflights offers flight deals from Manchester to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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