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$378+ Cheap flights from Manchester, NH to Florence, SC (MHT - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/20. Fares are subject to change and may not be available on all flights or dates of travel.
MHT — FLO
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Manchester to Florence

Cheapest flights from Manchester to Florence
Explore the most affordable flight options available from Manchester to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:00 amMHT - FLO
2 stops12h 07mAmerican Airlines
Mon 11/2410:29 amFLO - MHT
2 stops13h 29mAmerican Airlines
Deal found 10/30$378
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/234:15 pmMHT - FLO
2 stops8h 00mAmerican Airlines
Fri 1/25:15 amFLO - MHT
1 stop6h 50mAmerican Airlines
Deal found 10/29$480
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1212:09 pmMHT - FLO
2 stops22h 36mAmerican Airlines
Wed 11/1910:29 amFLO - MHT
2 stops13h 29mAmerican Airlines
Deal found 10/29$528
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/114:05 pmMHT - FLO
1 stop6h 48mAmerican Airlines
Sat 11/155:15 amFLO - MHT
1 stop6h 18mAmerican Airlines
Deal found 10/29$539
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:00 amMHT - FLO
2 stops16h 53mAmerican Airlines
Tue 11/1811:14 amFLO - MHT
2 stops24h 25mAmerican Airlines
Deal found 10/29$543
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:43 amMHT - FLO
1 stop5h 02mAmerican Airlines
Sat 11/155:15 amFLO - MHT
1 stop6h 18mAmerican Airlines
Deal found 10/29$554

Cheap flight deals from Manchester to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Manchester (MHT) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$378
(American Airlines)

Popular in

April

Cheapest in

November

Average price

$516
Provider with most accurate pricing for Manchester-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Manchester-Florence flights.
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From Manchester to Florence
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($48 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Manchester to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Manchester to Florence that are best for you.

Fly from

Manchester

Fly to

Florence

Route

Depart

Return

Price

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Thu 1/1

6:03 am-12:15 am

2 stops18h 12m

Florence

Tue 1/6

5:36 pm-11:35 am

2 stops17h 59m

$378

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Thu 11/20

5:20 pm-10:45 am

2 stops17h 25m

Florence

Mon 11/24

10:29 am-11:58 pm

2 stops13h 29m

$442

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Tue 12/23

4:40 pm-12:15 am

1 stop7h 35m

Florence

Fri 1/2

6:30 pm-12:45 am

1 stop6h 15m

$510

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Wed 2/25

4:23 pm-11:10 pm

1 stop6h 47m

Florence

Tue 3/3

6:15 am-3:45 pm

2 stops9h 30m

$516

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Tue 2/24

6:00 am-5:23 pm

2 stops11h 23m

Florence

Tue 3/3

6:15 am-3:45 pm

2 stops9h 30m

$521

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Wed 3/25

5:43 am-10:24 am

1 stop4h 41m

Florence

Sat 3/28

11:09 am-4:42 pm

1 stop5h 33m

$531

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Thu 11/20

5:20 pm-11:41 pm

2 stops6h 21m

$408

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Compare providers for flights from Manchester to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Manchester to Florence in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Manchester, New Hampshire-Florence, South Carolina flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Manchester, New Hampshire-Florence, South Carolina flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Manchester, New Hampshire-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Manchester, New Hampshire-Florence, South Carolina flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Manchester, New Hampshire-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Manchester to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Manchester with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Manchester to Florence

What is the cheapest month to book a flight from Manchester, New Hampshire to Florence, South Carolina?

Currently, August is the cheapest month in which you can book a flight from Manchester, New Hampshire to Florence, South Carolina (average of $58). Flying from Manchester, New Hampshire to Florence, South Carolina in June is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated October 30, 2025.
Read through reviews of airlines operating flights from Manchester to Florence, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,034 reviews

Comfort

7.2

Entertainment

6.9

Crew

8.0

Overall

7.2

Boarding

7.5

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
11,034 reviews
American Airlines
7.2
Good
11,034 reviews

Comfort

7.2

Entertainment

6.9

Crew

8.0

Overall

7.2

Boarding

7.5

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Manchester to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Manchester, New Hampshire to Florence, South Carolina?

    American Airlines can get you from Manchester, New Hampshire to Florence, South Carolina in just under 18h 12m. Your travel time can differ by up to . Manchester, New Hampshire and Florence, South Carolina are separated by a distance of 751 mi.

  • Can I find deals for flights from Manchester to Florence that include hotel bookings?

    Yes. In addition to deals on Manchester to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Manchester to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Manchester to Florence.

  • Can I find deals for business class flights from Manchester to Florence?

    Yes. Cheapflights offers flight deals from Manchester to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Manchester, New Hampshire to Florence, South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Manchester, New Hampshire to Florence, South Carolina (average of $58). Flying from Manchester, New Hampshire to Florence, South Carolina in June is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Top airline flying from Manchester to Florence

Discover the top airline that operate flights from Manchester to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$412Average$424FlexibilityNo cancel feeOn-time71%

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