HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$438+ Cheap flights from Manchester, NH to Florence, SC (MHT - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/4. Fares are subject to change and may not be available on all flights or dates of travel.
MHT — FLO
Dec 20 — Dec 271
Sat 12/20
Sat 12/27
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Manchester to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Manchester to Florence

Cheapest flights from Manchester to Florence
Explore the most affordable flight options available from Manchester to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 20, 2025.

This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/412:17 pmMHT - FLO
2 stops11h 46mAmerican Airlines
Mon 12/810:28 amFLO - MHT
2 stops13h 29mAmerican Airlines
Deal found 11/19$438
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/295:25 amMHT - FLO
1 stop5h 20mAmerican Airlines
Sat 12/66:31 pmFLO - MHT
1 stop4h 16mAmerican Airlines
Deal found 11/19$469
This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/135:45 amMHT - FLO
2 stops18h 30mAmerican Airlines
Wed 12/1710:28 amFLO - MHT
2 stops13h 29mAmerican Airlines
Deal found 11/18$498

Cheap flight deals from Manchester to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Manchester (MHT) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 20, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$438
(American Airlines)

Popular in

April

Cheapest in

November

Average price

$425
Provider with most accurate pricing for Manchester-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Manchester-Florence flights.
Search Deals
From Manchester to Florence
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($49 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Manchester to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 20, 2025.
Use the filters below to find and compare flights from Manchester to Florence that are best for you.

Fly from

Manchester

Fly to

Florence

Route

Depart

Return

Price

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Thu 12/4

12:17 pm-12:03 am

2 stops11h 46m

Florence

Mon 12/8

10:28 am-11:57 pm

2 stops13h 29m

$438

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Sat 12/13

5:45 am-12:15 am

2 stops18h 30m

Florence

Wed 12/17

10:28 am-11:57 pm

2 stops13h 29m

$498

ManchesterFlorence

MHT - FLO

MHTFLO

Manchester

Mon 1/5

4:40 pm-12:15 am

1 stop7h 35m

Florence

Fri 1/9

6:15 am-1:17 pm

1 stop7h 02m

$805

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/19

Compare providers for flights from Manchester to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Manchester to Florence in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Manchester, New Hampshire-Florence, South Carolina flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Manchester, New Hampshire-Florence, South Carolina flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Manchester, New Hampshire-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Manchester, New Hampshire-Florence, South Carolina flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Manchester, New Hampshire-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Manchester to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Manchester with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Manchester to Florence

What is the cheapest month to book a flight from Manchester, New Hampshire to Florence, South Carolina?

Currently, August is the cheapest month in which you can book a flight from Manchester, New Hampshire to Florence, South Carolina (average of $58). Flying from Manchester, New Hampshire to Florence, South Carolina in June is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated November 20, 2025.
Read through reviews of airlines operating flights from Manchester to Florence, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,047 reviews

Food

6.4

Boarding

7.5

Overall

7.2

Crew

8.0

Comfort

7.2

Entertainment

6.9

Reviews

1 / 20
8.0
Excellent

Monica,Nov 2025

JAC - DFW

At least there was an option of entertainment on this flight.
American Airlines
7.2
Good
11,047 reviews
American Airlines
7.2
Good
11,047 reviews

Food

6.4

Boarding

7.5

Overall

7.2

Crew

8.0

Comfort

7.2

Entertainment

6.9

Reviews

1 / 20
8.0
Excellent

Monica,Nov 2025

JAC - DFW

At least there was an option of entertainment on this flight.

Related info for your journey

Find useful and relevant information for your journey from Manchester to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Manchester, New Hampshire to Florence, South Carolina?

    American Airlines can get you from Manchester, New Hampshire to Florence, South Carolina in just under 11h 46m. Your travel time can differ by up to . Manchester, New Hampshire and Florence, South Carolina are separated by a distance of 751 mi.

  • Can I find deals for flights from Manchester to Florence that include hotel bookings?

    Yes. In addition to deals on Manchester to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Manchester to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Manchester to Florence.

  • Can I find deals for business class flights from Manchester to Florence?

    Yes. Cheapflights offers flight deals from Manchester to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Manchester, New Hampshire to Florence, South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Manchester, New Hampshire to Florence, South Carolina (average of $58). Flying from Manchester, New Hampshire to Florence, South Carolina in June is currently the most expensive (average of $76). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Manchester to Florence

See prices for flight routes from nearby airports that may be better suited for you.
Boston to Charlotte flights
Boston to Savannah flights
Boston to Charleston flights
Manchester to Charlotte flights
Boston to Myrtle Beach flights
Manchester to Myrtle Beach flights
Manchester to Charleston flights
Boston to Greenville flights
Portland to Charlotte flights
Manchester to Greenville flights
Boston to Columbia flights
Boston to Augusta flights
Manchester to Savannah flights
Portland to Myrtle Beach flights
Boston to Hilton Head Island flights
Portland to Savannah flights
Manchester to Columbia flights
Portland to Charleston flights
Worcester to Charleston flights
Portland to Greenville flights
Manchester to Hilton Head Island flights
Portland to Columbia flights
Portland to Augusta flights
Portland to Hilton Head Island flights
Boston to Florence flights
Manchester to Augusta flights
Portland to Florence flights

Top airline flying from Manchester to Florence

Discover the top airline that operate flights from Manchester to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$412Average$424FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.