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$249+ Cheap flights from La Crosse (LSE) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/8. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — RDU
Mar 20 — Mar 271
Fri 3/20
Fri 3/27
1 adult, Economy
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Cheap flight deals from La Crosse to Durham

Cheapest flights from La Crosse to Durham
Explore the most affordable flight options available from La Crosse to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 18, 2026.

This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/175:09 am
LSE
-
RDU
1 stop10h 49m
American Airlines
Wed 3/254:28 pm
RDU
-
LSE
1 stop8h 08m
American Airlines
Deal found 2/18$334
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:09 am
LSE
-
RDU
1 stop10h 49m
American Airlines
Sat 4/47:20 pm
RDU
-
LSE
1 stop5h 16m
American Airlines
Deal found 2/17$426
This American Airlines deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/211:34 am
LSE
-
RDU
1 stop11h 33m
American Airlines
Tue 4/73:54 pm
RDU
-
LSE
1 stop9h 00m
American Airlines
Deal found 2/14$433
This American Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:37 pm
LSE
-
RDU
1 stop4h 22m
American Airlines
Sun 4/195:45 am
RDU
-
LSE
1 stop4h 50m
American Airlines
Deal found 2/15$457

Find flight deals from La Crosse to Durham

Keep the following information in mind while searching for La Crosse to Durham flight deals. Data was last updated February 18, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$334
(American Airlines)

One-way from

$249
(Kiwi.com)

Popular in

June

Cheapest in

April

Average price

$708
Provider with most accurate pricing for La Crosse-Raleigh-Durham flight deals.
Search Deals
Provider most trusted by Cheapflights users for La Crosse-Raleigh-Durham flights.
Search Deals
From La Crosse to Durham
Search Deals
One-way flight from La Crosse to Durham
Search Deals
Highest demand for flights based on searches. 29% potential increase in price ($260 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 11% potential price decrease ($63 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from La Crosse to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 18, 2026.
Use the filters below to find and compare flights from La Crosse to Durham that are best for you.

Fly from

La Crosse

Fly to

Durham

Route

Depart

Return

Price

La CrosseRaleigh

LSE - RDU

LSERDU

La Crosse

Wed 3/18

5:09 am-4:58 pm

1 stop10h 49m

Raleigh-Durham

Wed 3/25

5:00 am-5:59 pm

1 stop13h 59m

$334

La CrosseRaleigh

LSE - RDU

LSERDU

La Crosse

Tue 3/17

5:09 am-5:40 pm

1 stop11h 31m

Raleigh-Durham

Wed 3/25

6:39 am-5:59 pm

1 stop12h 20m

$334

La CrosseRaleigh

LSE - RDU

LSERDU

La Crosse

Tue 3/31

5:09 am-4:58 pm

1 stop10h 49m

Raleigh-Durham

Sat 4/4

7:20 pm-11:36 pm

1 stop5h 16m

$426

La CrosseRaleigh

LSE - RDU

LSERDU

La Crosse

Thu 4/2

11:34 am-12:07 am

1 stop11h 33m

Raleigh-Durham

Tue 4/7

3:54 pm-11:54 pm

1 stop9h 00m

$433

La CrosseRaleigh

LSE - RDU

LSERDU

La Crosse

Wed 4/15

6:37 pm-11:59 pm

1 stop4h 22m

Raleigh-Durham

Sun 4/19

5:45 am-9:35 am

1 stop4h 50m

$457

La CrosseRaleigh

LSE - RDU

LSERDU

La Crosse

Fri 5/8

12:43 pm-12:15 am

3 stops34h 32m

$249

La CrosseRaleigh

LSE - RDU

LSERDU

La Crosse

Fri 5/8

1:49 pm-5:23 pm

1 stop26h 34m

$320

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/14

Best time to book a flight from La Crosse to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from La Crosse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from La Crosse to Durham

What is the cheapest month to book a flight from La Crosse to Durham?

Currently, May is the cheapest month in which you can book a flight from La Crosse to Durham (average of $228). Flying from La Crosse to Durham in February is currently the most expensive (average of $490). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated February 18, 2026.
See what other customers who have flown with American Airlines from La Crosse to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,304 reviews

Boarding

7.5

Comfort

7.2

Entertainment

6.9

Food

6.4

Crew

8.0

Overall

7.2

Reviews

1 / 20
10.0
Excellent

Susie,Jan 2026

DAY - CLT

We weren’t offered any beverages on this flight. It was not bumpy at all
American Airlines
7.2
Good
11,304 reviews
American Airlines
7.2
Good
11,304 reviews

Boarding

7.5

Comfort

7.2

Entertainment

6.9

Food

6.4

Crew

8.0

Overall

7.2

Reviews

1 / 20
10.0
Excellent

Susie,Jan 2026

DAY - CLT

We weren’t offered any beverages on this flight. It was not bumpy at all

Related info for your journey

Find useful and relevant information for your journey from La Crosse to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from La Crosse to Durham?

    Located just 5.4 mi from the city center, La Crosse is the airport most travelers will use when flying to Durham from La Crosse. Booking flights from La Crosse (LSE) to Durham should be relatively easy as there are 0 daily outbound flights to Durham from 1 airline.

  • How long is the flight from La Crosse to Durham?

    Airlines like American Airlines fly from La Crosse to Durham in about 10h 49m. The time it takes to get you to your destination can typically vary by up to . There are 859 mi between La Crosse and Durham.

  • Can I find deals for flights from La Crosse to Durham that include hotel bookings?

    Yes. In addition to deals on La Crosse to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from La Crosse to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from La Crosse to Durham.

  • Can I find deals for business class flights from La Crosse to Durham?

    Yes. Cheapflights offers flight deals from La Crosse to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from La Crosse to Durham?

    Currently, May is the cheapest month in which you can book a flight from La Crosse to Durham (average of $228). Flying from La Crosse to Durham in February is currently the most expensive (average of $490). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from La Crosse to Durham

Discover the top airline that operate flights from La Crosse to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 18, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$410Average$568FlexibilityNo cancel feeOn-time71%

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