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$410+ Cheap flights from La Crosse (LSE) to Durham, NC

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/21. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — RDU
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from La Crosse to Durham

Keep the following information in mind while searching for La Crosse to Durham flight deals. Data was last updated September 17, 2025.

Round-trip from

$410
(American Airlines)

Popular in

June

Cheapest in

December

Average price

$507
From La Crosse to Durham
Search Deals
Highest demand for flights based on searches. 33% potential increase in price ($296 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 12% potential price decrease ($67 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from La Crosse to Durham

Cheapest flights from La Crosse to Durham
Explore the most affordable flight options available from La Crosse to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/216:15 pmLSE - RDU
1 stop4h 38mAmerican Airlines
Tue 10/287:00 amRDU - LSE
1 stop4h 24mAmerican Airlines
Deal found 9/16$410
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:02 pmLSE - RDU
1 stop4h 53mAmerican Airlines
Mon 11/106:00 amRDU - LSE
1 stop4h 20mAmerican Airlines
Deal found 9/16$464
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/216:00 amLSE - RDU
1 stop5h 58mAmerican Airlines
Wed 10/227:08 pmRDU - LSE
1 stop5h 18mAmerican Airlines
Deal found 9/17$756

Cheapflights Fare Finder

 
Customize your flight search to find flights from La Crosse to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from La Crosse to Durham that are best for you.

Fly from

La Crosse

Fly to

Durham

Route

Depart

Return

Price

La CrosseRaleigh

LSE - RDU

LSERDU

La Crosse

Tue 10/21

6:00 am-4:06 pm

2 stops9h 06m

Raleigh-Durham

Tue 10/28

7:00 am-10:24 am

1 stop4h 24m

$416

La CrosseRaleigh

LSE - RDU

LSERDU

La Crosse

Thu 11/6

6:02 pm-11:55 pm

1 stop4h 53m

Raleigh-Durham

Mon 11/10

6:00 am-9:20 am

1 stop4h 20m

$464

La CrosseRaleigh

LSE - RDU

LSERDU

La Crosse

Tue 10/21

6:00 am-12:58 pm

1 stop5h 58m

Raleigh-Durham

Wed 10/22

7:08 pm-11:26 pm

1 stop5h 18m

$756

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Best time to book a flight from La Crosse to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from La Crosse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from La Crosse to Durham

What is the cheapest month to book a flight from La Crosse to Durham?

Currently, August is the cheapest month in which you can book a flight from La Crosse to Durham (average of $206). Flying from La Crosse to Durham in March is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated September 17, 2025.
See what other customers who have flown with American Airlines from La Crosse to Durham have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Boarding

7.5

Food

6.4

Crew

8.0

Entertainment

6.9

Overall

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Boarding

7.5

Food

6.4

Crew

8.0

Entertainment

6.9

Overall

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.

Related info for your journey

Find useful and relevant information for your journey from La Crosse to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from La Crosse to Durham?

    Located just 5.4 mi from the city center, La Crosse is the airport most travelers will use when flying to Durham from La Crosse. Booking flights from La Crosse (LSE) to Durham should be relatively easy as there are 0 daily outbound flights to Durham from 1 airline.

  • How long is the flight from La Crosse to Durham?

    Airlines like American Airlines fly from La Crosse to Durham in about 9h 06m. The time it takes to get you to your destination can typically vary by up to . There are 859 mi between La Crosse and Durham.

  • Can I find deals for flights from La Crosse to Durham that include hotel bookings?

    Yes. In addition to deals on La Crosse to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from La Crosse to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from La Crosse to Durham.

  • Can I find deals for business class flights from La Crosse to Durham?

    Yes. Cheapflights offers flight deals from La Crosse to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from La Crosse to Durham?

    Currently, August is the cheapest month in which you can book a flight from La Crosse to Durham (average of $206). Flying from La Crosse to Durham in March is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from La Crosse to Durham

Discover the top airline that operate flights from La Crosse to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$435Average$484FlexibilityNo cancel feeOn-time71%

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