$551+ Cheap flights from Florence, SC to Detroit (FLO - DTT)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/19. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — DTT
Oct 9 — Oct 161
Round-trip
1 adult, Economy
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Cheapest flights from Florence to DetroitExplore the most affordable flight options available from Florence to Detroit. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
Explore the most affordable flight options available from Florence to Detroit. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:24 am -
1 stop3h 57m
Wed 9/237:30 am -
1 stop5h 48m
Deal found 9/4![American Airlines logo]()
$551
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/12:35 pm -
1 stop4h 34m
Tue 12/811:00 am -
1 stop4h 16m
Deal found 9/7![American Airlines logo]()
$571
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/12:35 pm -
1 stop4h 34m
Thu 12/107:42 pm -
1 stop4h 14m
Deal found 9/7![American Airlines logo]()
$579
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/35:09 am -
1 stop4h 36m
Thu 12/107:42 pm -
1 stop4h 14m
Deal found 9/7![American Airlines logo]()
$587
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:24 am -
1 stop4h 06m
Tue 12/154:50 pm -
1 stop6h 09m
Deal found 9/7![American Airlines logo]()
$590
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:43 pm -
1 stop3h 47m
Mon 10/51:35 pm -
2 stops10h 22m
Deal found 9/7![American Airlines logo]()
$596
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:24 am -
1 stop4h 06m
Sun 12/137:42 pm -
1 stop4h 14m
Deal found 9/7![American Airlines logo]()
$598
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/12:35 pm -
1 stop4h 34m
Sat 12/51:55 pm -
2 stops9h 04m
Deal found 9/7![American Airlines logo]()
$638
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/12:35 pm -
2 stops8h 21m
Mon 12/76:25 pm -
1 stop4h 34m
Deal found 9/7![American Airlines logo]()
$646
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/241:43 pm -
1 stop3h 47m
Sun 9/277:15 am -
1 stop6h 55m
Deal found 9/5![American Airlines logo]()
$649
Best flights from Florence to DetroitDiscover carefully curated flight deals from Florence to Detroit that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
Discover carefully curated flight deals from Florence to Detroit that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:24 am -
1 stop3h 57m
Wed 9/237:30 am -
1 stop5h 48m
Deal found 9/4![American Airlines logo]()
$551
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:24 am -
1 stop4h 06m
Sun 12/137:42 pm -
1 stop4h 14m
Deal found 9/7![American Airlines logo]()
$579
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:09 am -
1 stop4h 36m
Sat 12/1211:00 am -
1 stop4h 09m
Deal found 9/7![American Airlines logo]()
$579
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:43 pm -
1 stop3h 47m
Mon 10/51:35 pm -
2 stops10h 22m
Deal found 9/7![American Airlines logo]()
$596
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/11:43 pm -
1 stop3h 47m
Mon 10/57:55 pm -
1 stop4h 02m
Deal found 9/7![American Airlines logo]()
$649
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/21:43 pm -
1 stop3h 47m
Sun 10/47:15 am -
1 stop6h 55m
Deal found 9/5![American Airlines logo]()
$649
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/123:37 pm -
2 stops7h 39m
Tue 12/156:35 am -
2 stops8h 41m
Deal found 9/7![American Airlines logo]()
$705
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/302:35 pm -
1 stop4h 28m
Wed 12/99:31 am -
2 stops5h 38m
Deal found 9/7![American Airlines logo]()
$737
Last-minute flights from Florence to DetroitDiscover last-minute flight deals from Florence to Detroit. Data last updated September 9, 2026 and is based on user searches.
Discover last-minute flight deals from Florence to Detroit. Data last updated September 9, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:24 am -
1 stop3h 57m
Wed 9/237:30 am -
1 stop5h 48m
Deal found 9/4![American Airlines logo]()
$551
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/211:43 pm -
1 stop3h 47m
Fri 9/257:30 am -
1 stop5h 48m
Deal found 9/6![American Airlines logo]()
$965
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/241:43 pm -
1 stop3h 47m
Sun 9/277:15 am -
1 stop6h 55m
Deal found 9/5![American Airlines logo]()
$649
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:43 pm -
1 stop3h 47m
Mon 10/51:35 pm -
2 stops10h 22m
Deal found 9/7![American Airlines logo]()
$596
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:24 am -
2 stops13h 12m
Sun 10/47:15 am -
1 stop6h 55m
Deal found 9/5![American Airlines logo]()
$764
Find flight deals from Florence to Detroit
Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to Detroit (DTT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $551 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Florence to Detroit that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
Use the filters below to find and compare flights from Florence to Detroit that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
FlorenceDetroit
FLO Florence - DTW Detroit Metropolitan Wayne County
FLODTW
Florence
Sat 9/19
6:24 am-10:21 am
1 stop3h 57m
Detroit Metropolitan Wayne County
Wed 9/23
7:30 am-1:18 pm
1 stop5h 48m
$551
FlorenceDetroit
FLO Florence - DTW Detroit Metropolitan Wayne County
FLODTW
Florence
Wed 12/9
6:24 am-10:30 am
1 stop4h 06m
Detroit Metropolitan Wayne County
Sun 12/13
7:42 pm-11:56 pm
1 stop4h 14m
$579
FlorenceDetroit
FLO Florence - DTW Detroit Metropolitan Wayne County
FLODTW
Florence
Fri 12/11
5:09 am-9:45 am
1 stop4h 36m
Detroit Metropolitan Wayne County
Sat 12/12
11:00 am-3:09 pm
1 stop4h 09m
$579
FlorenceDetroit
FLO Florence - DTW Detroit Metropolitan Wayne County
FLODTW
Florence
Wed 9/30
1:43 pm-5:30 pm
1 stop3h 47m
Detroit Metropolitan Wayne County
Mon 10/5
1:35 pm-11:57 pm
2 stops10h 22m
$596
Quickest round-trip
FlorenceDetroit
FLO Florence - DTW Detroit Metropolitan Wayne County
FLODTW
Florence
Thu 10/1
1:43 pm-5:30 pm
1 stop3h 47m
Detroit Metropolitan Wayne County
Mon 10/5
7:55 pm-11:57 pm
1 stop4h 02m
$649
FlorenceDetroit
FLO Florence - DTW Detroit Metropolitan Wayne County
FLODTW
Florence
Fri 10/2
1:43 pm-5:30 pm
1 stop3h 47m
Detroit Metropolitan Wayne County
Sun 10/4
7:15 am-2:10 pm
1 stop6h 55m
$649
FlorenceDetroit
FLO Florence - DTW Detroit Metropolitan Wayne County
FLODTW
Florence
Sat 12/12
3:37 pm-11:16 pm
2 stops7h 39m
Detroit Metropolitan Wayne County
Tue 12/15
6:35 am-3:16 pm
2 stops8h 41m
$705
FlorenceDetroit
FLO Florence - DTW Detroit Metropolitan Wayne County
FLODTW
Florence
Mon 11/30
2:35 pm-7:03 pm
1 stop4h 28m
Detroit Metropolitan Wayne County
Wed 12/9
9:31 am-3:09 pm
2 stops5h 38m
$737
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Florence, South Carolina-Detroit flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Florence, South Carolina-Detroit flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-Detroit flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Florence, South Carolina-Detroit flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-Detroit flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Florence to Detroit
Have a flexible travel schedule? Discover the best time to fly to Detroit from Florence with our price prediction graph.
FLO-DTT
FLO-DTW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Florence to Detroit
FLO-DTT
FLO-DTW
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Florence to Detroit. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Detroit?
Book flights to Detroit if you plan to visit one of these locationsRoseville
Port Huron
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