$552+ Cheap flights from Florence, SC to Detroit (FLO - DTT)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/10. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — DTT
Sep 25 — Oct 21
Round-trip
1 adult, Economy
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Find cheap flights from Florence to Detroit with Cheapflights
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Cheapest flights from Florence to DetroitExplore the most affordable flight options available from Florence to Detroit. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 26, 2026.
Explore the most affordable flight options available from Florence to Detroit. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 26, 2026.
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:24 am -
2 stops15h 20m
Thu 11/121:30 pm -
2 stops10h 26m
Deal found 8/21![American Airlines logo]()
$552
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:00 am -
1 stop3h 47m
Sat 9/127:30 am -
1 stop5h 48m
Deal found 8/22![American Airlines logo]()
$590
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/23:22 pm -
1 stop7h 08m
Wed 9/97:30 am -
1 stop5h 48m
Deal found 8/22![American Airlines logo]()
$609
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:00 am -
1 stop3h 47m
Thu 9/107:30 am -
1 stop5h 48m
Deal found 8/22![American Airlines logo]()
$610
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/23:22 pm -
1 stop7h 08m
Fri 9/117:30 am -
1 stop5h 48m
Deal found 8/22![American Airlines logo]()
$629
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:00 am -
1 stop3h 47m
Sun 9/137:59 pm -
1 stop3h 58m
Deal found 8/22![American Airlines logo]()
$630
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:22 am -
1 stop5h 13m
Fri 9/117:30 am -
1 stop5h 48m
Deal found 8/22![American Airlines logo]()
$649
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/33:22 pm -
1 stop7h 08m
Sun 9/137:15 am -
1 stop6h 55m
Deal found 8/22![American Airlines logo]()
$669
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:22 am -
2 stops10h 11m
Mon 9/147:30 am -
1 stop5h 48m
Deal found 8/22![American Airlines logo]()
$677
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/69:00 am -
1 stop3h 47m
Mon 9/148:47 pm -
2 stops16h 31m
Deal found 8/22![American Airlines logo]()
$681
Best flights from Florence to DetroitDiscover carefully curated flight deals from Florence to Detroit that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 26, 2026.
Discover carefully curated flight deals from Florence to Detroit that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 26, 2026.
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:00 am -
1 stop3h 47m
Sun 9/137:59 pm -
1 stop3h 58m
Deal found 8/22![American Airlines logo]()
$630
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:22 am -
1 stop5h 13m
Mon 9/147:30 am -
1 stop5h 48m
Deal found 8/22![American Airlines logo]()
$649
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:00 am -
2 stops11h 13m
Thu 9/107:30 am -
1 stop5h 48m
Deal found 8/22![American Airlines logo]()
$677
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:22 am -
1 stop5h 13m
Fri 9/112:13 pm -
2 stops23h 05m
Deal found 8/22![American Airlines logo]()
$823
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:22 am -
1 stop5h 13m
Wed 9/97:30 am -
1 stop5h 48m
Deal found 8/22![American Airlines logo]()
$897
Last-minute flights from Florence to DetroitDiscover last-minute flight deals from Florence to Detroit. Data last updated August 26, 2026 and is based on user searches.
Discover last-minute flight deals from Florence to Detroit. Data last updated August 26, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/23:22 pm -
1 stop7h 08m
Wed 9/97:30 am -
1 stop5h 48m
Deal found 8/22![American Airlines logo]()
$609
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/23:22 pm -
1 stop7h 08m
Fri 9/117:30 am -
1 stop5h 48m
Deal found 8/22![American Airlines logo]()
$629
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:22 am -
2 stops10h 11m
Mon 9/147:30 am -
1 stop5h 48m
Deal found 8/22![American Airlines logo]()
$677
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:22 am -
2 stops10h 14m
Sun 9/137:59 pm -
1 stop3h 58m
Deal found 8/22![American Airlines logo]()
$697
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:22 am -
1 stop5h 13m
Fri 9/117:30 am -
1 stop5h 48m
Deal found 8/22![American Airlines logo]()
$649
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/33:22 pm -
1 stop7h 08m
Sun 9/137:15 am -
1 stop6h 55m
Deal found 8/22![American Airlines logo]()
$669
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:00 am -
1 stop3h 47m
Sat 9/127:30 am -
1 stop5h 48m
Deal found 8/22![American Airlines logo]()
$590
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:00 am -
1 stop3h 47m
Thu 9/107:30 am -
1 stop5h 48m
Deal found 8/22![American Airlines logo]()
$610
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:00 am -
1 stop3h 47m
Sun 9/137:59 pm -
1 stop3h 58m
Deal found 8/22![American Airlines logo]()
$630
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/69:00 am -
1 stop3h 47m
Mon 9/148:47 pm -
2 stops16h 31m
Deal found 8/22![American Airlines logo]()
$681
Find flight deals from Florence to Detroit
Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to Detroit (DTT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $552 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Florence to Detroit that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 26, 2026.
Use the filters below to find and compare flights from Florence to Detroit that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
FlorenceDetroit
FLO Florence - DTW Detroit Metropolitan Wayne County
FLODTW
Florence
Sat 9/5
9:00 am-12:47 pm
1 stop3h 47m
Detroit Metropolitan Wayne County
Sun 9/13
7:59 pm-11:57 pm
1 stop3h 58m
$630
FlorenceDetroit
FLO Florence - DTW Detroit Metropolitan Wayne County
FLODTW
Florence
Mon 9/7
6:22 am-11:35 am
1 stop5h 13m
Detroit Metropolitan Wayne County
Mon 9/14
7:30 am-1:18 pm
1 stop5h 48m
$649
FlorenceDetroit
FLO Florence - DTW Detroit Metropolitan Wayne County
FLODTW
Florence
Sat 9/5
9:00 am-8:13 pm
2 stops11h 13m
Detroit Metropolitan Wayne County
Thu 9/10
7:30 am-1:18 pm
1 stop5h 48m
$677
FlorenceDetroit
FLO Florence - DTW Detroit Metropolitan Wayne County
FLODTW
Florence
Mon 9/7
6:22 am-11:35 am
1 stop5h 13m
Detroit Metropolitan Wayne County
Fri 9/11
2:13 pm-1:18 pm
2 stops23h 05m
$823
FlorenceDetroit
FLO Florence - DTW Detroit Metropolitan Wayne County
FLODTW
Florence
Tue 9/8
6:22 am-11:35 am
1 stop5h 13m
Detroit Metropolitan Wayne County
Wed 9/9
7:30 am-1:18 pm
1 stop5h 48m
$897
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Florence, South Carolina-Detroit flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Florence, South Carolina-Detroit flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-Detroit flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Florence, South Carolina-Detroit flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-Detroit flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Florence to Detroit
Have a flexible travel schedule? Discover the best time to fly to Detroit from Florence with our price prediction graph.
FLO-DTT
FLO-DTW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Florence to Detroit
FLO-DTT
FLO-DTW
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Florence to Detroit. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Detroit?
Book flights to Detroit if you plan to visit one of these locationsRoseville
Port Huron
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