$117+ Cheap flights from Portland to Des Moines (PDX - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/15. Fares are subject to change and may not be available on all flights or dates of travel.
PDX — DSM
Mar 5 — Mar 121
1 adult, Economy
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Find cheap flights from Portland to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Portland to Des Moines are usually found in September or July, booked 68 days in advance, depart on a Tuesday or Monday and return on a Saturday
Cheap flight deals from Portland to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Portland to Des MoinesExplore the most affordable flight options available from Portland to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
Explore the most affordable flight options available from Portland to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1411:48 am
PDX
- DSM
1 stop23h 41m
Frontier
Mon 5/182:20 pm
DSM
- PDX
1 stop24h 42m
Frontier
Deal found 2/1![Frontier logo]()
$242
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/111:52 pm
PDX
- DSM
1 stop8h 07m
American Airlines
Sat 4/186:00 am
DSM
- PDX
1 stop10h 24m
American Airlines
Deal found 1/31![American Airlines logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1411:48 am
PDX
- DSM
1 stop23h 41m
Multiple Airlines
Mon 5/183:32 pm
DSM
- PDX
2 stops23h 30m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:44 pm
PDX
- DSM
Nonstop3h 14m
Allegiant Air
Sun 7/53:06 pm
DSM
- PDX
Nonstop3h 39m
Allegiant Air
Deal found 1/31![Allegiant Air logo]()
$345
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/235:38 am
PDX
- DSM
1 stop7h 24m
American Airlines
Sat 8/299:00 am
DSM
- PDX
1 stop16h 22m
American Airlines
Deal found 2/1![American Airlines logo]()
$375
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:40 am
PDX
- DSM
1 stop7h 16m
American Airlines
Tue 3/101:37 pm
DSM
- PDX
1 stop12h 43m
American Airlines
Deal found 2/2![American Airlines logo]()
$377
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/118:40 am
PDX
- DSM
1 stop5h 35m
United Airlines
Sat 4/189:00 am
DSM
- PDX
2 stops11h 08m
United Airlines
Deal found 1/31![United Airlines logo]()
$382
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/312:57 pm
PDX
- DSM
1 stop7h 23m
United Airlines
Tue 3/105:30 am
DSM
- PDX
2 stops9h 03m
United Airlines
Deal found 2/2![United Airlines logo]()
$397
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1812:52 pm
PDX
- DSM
1 stop7h 41m
Multiple Airlines
Thu 5/213:06 pm
DSM
- PDX
Nonstop3h 44m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$403
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2612:57 pm
PDX
- DSM
1 stop7h 23m
United Airlines
Tue 3/39:04 am
DSM
- PDX
1 stop6h 40m
United Airlines
Deal found 2/2![United Airlines logo]()
$412
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1811:55 pm
PDX
- DSM
1 stop9h 30m
Southwest
Thu 5/2112:25 pm
DSM
- PDX
1 stop9h 45m
Southwest
Deal found 2/3![Southwest logo]()
$413
Best flights from Portland to Des MoinesDiscover carefully curated flight deals from Portland to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
Discover carefully curated flight deals from Portland to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1411:48 am
PDX
- DSM
1 stop23h 41m
Frontier
Mon 5/182:20 pm
DSM
- PDX
1 stop24h 42m
Frontier
Deal found 2/1![Frontier logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:44 pm
PDX
- DSM
Nonstop3h 14m
Allegiant Air
Sun 7/53:06 pm
DSM
- PDX
Nonstop3h 39m
Allegiant Air
Deal found 1/31![Allegiant Air logo]()
$345
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:40 am
PDX
- DSM
1 stop7h 16m
American Airlines
Tue 3/101:37 pm
DSM
- PDX
1 stop12h 43m
American Airlines
Deal found 2/2![American Airlines logo]()
$377
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/118:40 am
PDX
- DSM
1 stop5h 35m
United Airlines
Sat 4/189:00 am
DSM
- PDX
2 stops11h 08m
United Airlines
Deal found 1/31![United Airlines logo]()
$382
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1011:15 pm
PDX
- DSM
1 stop8h 32m
Delta
Sat 4/1810:58 am
DSM
- PDX
1 stop8h 34m
Delta
Deal found 1/31![Delta logo]()
$402
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1812:52 pm
PDX
- DSM
1 stop7h 41m
Multiple Airlines
Thu 5/213:06 pm
DSM
- PDX
Nonstop3h 44m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$403
This Southwest deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/119:35 am
PDX
- DSM
2 stops9h 20m
Southwest
Sat 4/186:40 am
DSM
- PDX
2 stops8h 15m
Southwest
Deal found 1/31![Southwest logo]()
$412
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/312:57 pm
PDX
- DSM
1 stop7h 23m
United Airlines
Tue 3/105:30 am
DSM
- PDX
2 stops9h 03m
United Airlines
Deal found 2/2![United Airlines logo]()
$397
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2612:09 pm
PDX
- DSM
1 stop8h 19m
Delta
Tue 3/34:20 pm
DSM
- PDX
1 stop6h 10m
Delta
Deal found 2/3![Delta logo]()
$412
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1811:55 pm
PDX
- DSM
1 stop9h 30m
Southwest
Thu 5/2112:25 pm
DSM
- PDX
1 stop9h 45m
Southwest
Deal found 2/3![Southwest logo]()
$413
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2612:57 pm
PDX
- DSM
1 stop7h 23m
United Airlines
Tue 3/39:04 am
DSM
- PDX
1 stop6h 40m
United Airlines
Deal found 2/2![United Airlines logo]()
$412
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1011:15 pm
PDX
- DSM
1 stop8h 32m
Delta
Sun 4/194:23 pm
DSM
- PDX
1 stop5h 42m
Delta
Deal found 1/31![Delta logo]()
$427
Last-minute flights from Portland to Des MoinesDiscover last-minute flight deals from Portland to Des Moines. Data last updated February 3, 2026 and is based on user searches.
Discover last-minute flight deals from Portland to Des Moines. Data last updated February 3, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1812:40 am
PDX
- DSM
1 stop7h 37m
Delta
Tue 2/244:20 pm
DSM
- PDX
1 stop6h 10m
Delta
Deal found 2/3![Delta logo]()
$452
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1912:04 pm
PDX
- DSM
1 stop9h 44m
American Airlines
Thu 2/267:44 pm
DSM
- PDX
1 stop17h 18m
American Airlines
Deal found 2/1![American Airlines logo]()
$485
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2612:09 pm
PDX
- DSM
1 stop8h 19m
Delta
Tue 3/34:20 pm
DSM
- PDX
1 stop6h 10m
Delta
Deal found 2/3![Delta logo]()
$412
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:35 am
PDX
- DSM
2 stops9h 00m
Southwest
Tue 3/38:35 am
DSM
- PDX
1 stop9h 05m
Southwest
Deal found 2/3![Southwest logo]()
$463
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/21:52 pm
PDX
- DSM
1 stop7h 56m
American Airlines
Mon 3/97:44 pm
DSM
- PDX
1 stop17h 04m
American Airlines
Deal found 2/2![American Airlines logo]()
$432
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/29:25 am
PDX
- DSM
2 stops10h 50m
Southwest
Mon 3/94:20 pm
DSM
- PDX
2 stops10h 35m
Southwest
Deal found 2/2![Southwest logo]()
$457
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:40 am
PDX
- DSM
1 stop7h 16m
American Airlines
Tue 3/101:37 pm
DSM
- PDX
1 stop12h 43m
American Airlines
Deal found 2/2![American Airlines logo]()
$377
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/312:57 pm
PDX
- DSM
1 stop7h 23m
United Airlines
Tue 3/105:30 am
DSM
- PDX
2 stops9h 03m
United Airlines
Deal found 2/2![United Airlines logo]()
$397
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/511:59 pm
PDX
- DSM
1 stop8h 31m
United Airlines
Sun 3/85:30 am
DSM
- PDX
1 stop6h 24m
United Airlines
Deal found 2/2![United Airlines logo]()
$427
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/510:55 am
PDX
- DSM
2 stops9h 25m
Southwest
Sun 3/84:40 pm
DSM
- PDX
2 stops10h 20m
Southwest
Deal found 2/2![Southwest logo]()
$493
One-way flights from Portland to Des MoinesSearch for one-way flight options from Portland to Des Moines. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
Search for one-way flight options from Portland to Des Moines. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/1512:04 pm
PDX
- DSM
1 stop29h 12m
Frontier
Deal found 2/2![Frontier logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/95:19 pm
PDX
- DSM
2 stops23h 55m
Frontier
Deal found 1/31![Frontier logo]()
$150
This Frontier deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1311:58 am
PDX
- DSM
1 stop5h 16m
Frontier
Deal found 1/31![Frontier logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/151:48 pm
PDX
- DSM
2 stops28h 33m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$155
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1511:47 pm
PDX
- DSM
1 stop6h 39m
American Airlines
Deal found 2/2![American Airlines logo]()
$176
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/33:10 pm
PDX
- DSM
1 stop6h 49m
American Airlines
Deal found 2/1![American Airlines logo]()
$179
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/38:30 am
PDX
- DSM
2 stops11h 11m
United Airlines
Deal found 2/1![United Airlines logo]()
$184
This Frontier deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1011:58 am
PDX
- DSM
1 stop5h 16m
Frontier
Deal found 1/31![Frontier logo]()
$185
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1111:15 pm
PDX
- DSM
1 stop8h 31m
Delta
Deal found 1/31![Delta logo]()
$189
Find flight deals from Portland to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Portland (PDX) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $330 (American Airlines) |
One-way from | $117 (Kiwi.com) |
Popular in | January |
Cheapest in | September |
Average price | $374 |
Cheapflights Fare Finder
Customize your flight search to find flights from Portland to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Portland to Des Moines that are best for you.
Fly from
Portland
Fly to
Des Moines
Route
Depart
Return
Price
PortlandDes Moines
PDX - DSM
PDXDSM
Portland
Thu 5/14
11:48 am-1:29 pm
1 stop23h 41m
Des Moines
Mon 5/18
2:20 pm-1:02 pm
1 stop24h 42m
$242
PortlandDes Moines
PDX - DSM
PDXDSM
Portland
Sun 6/28
5:44 pm-10:58 pm
Nonstop3h 14m
Des Moines
Sun 7/5
3:06 pm-4:45 pm
Nonstop3h 39m
$345
PortlandDes Moines
PDX - DSM
PDXDSM
Portland
Tue 3/3
5:40 am-2:56 pm
1 stop7h 16m
Des Moines
Tue 3/10
1:37 pm-12:20 am
1 stop12h 43m
$377
PortlandDes Moines
PDX - DSM
PDXDSM
Portland
Sat 4/11
8:40 am-4:15 pm
1 stop5h 35m
Des Moines
Sat 4/18
9:00 am-6:08 pm
2 stops11h 08m
$382
PortlandDes Moines
PDX - DSM
PDXDSM
Portland
Tue 3/3
12:57 pm-10:20 pm
1 stop7h 23m
Des Moines
Tue 3/10
5:30 am-12:33 pm
2 stops9h 03m
$397
PortlandDes Moines
PDX - DSM
PDXDSM
Portland
Fri 4/10
11:15 pm-9:47 am
1 stop8h 32m
Des Moines
Sat 4/18
10:58 am-5:32 pm
1 stop8h 34m
$402
PortlandDes Moines
PDX - DSM
PDXDSM
Portland
Mon 5/18
12:52 pm-10:33 pm
1 stop7h 41m
Des Moines
Thu 5/21
3:06 pm-4:50 pm
Nonstop3h 44m
$403
PortlandDes Moines
PDX - DSM
PDXDSM
Portland
Sat 4/11
9:35 am-8:55 pm
2 stops9h 20m
Des Moines
Sat 4/18
6:40 am-12:55 pm
2 stops8h 15m
$412
PortlandDes Moines
PDX - DSM
PDXDSM
Portland
Thu 2/26
12:09 pm-10:28 pm
1 stop8h 19m
Des Moines
Tue 3/3
4:20 pm-8:30 pm
1 stop6h 10m
$412
PortlandDes Moines
PDX - DSM
PDXDSM
Portland
Thu 2/26
12:57 pm-10:20 pm
1 stop7h 23m
Des Moines
Tue 3/3
9:04 am-1:44 pm
1 stop6h 40m
$412
Showing 1-10 of 23 results
Compare providers for flights from Portland to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Portland to Des Moines in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*2 stars | |
| Price Accuracy- | Trust Score*1 star | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Portland-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Portland-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Portland-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Portland-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Portland-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Portland to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Portland with our price prediction graph.
PDX-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Portland to Des Moines
How far ahead should I book a flight from Portland to Des Moines?
Use this chart to determine the optimal time to book a round-trip flight from Portland to Des Moines. Price data was last updated on January 30, 2026.
The price you pay for your flight from Portland to Des Moines may vary depending on when you book. For the best chance of a lower fare, look to book 67 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Portland to Des Moines?
Currently, September is the cheapest month in which you can book a flight from Portland to Des Moines (average of $71). Flying from Portland to Des Moines in November is currently the most expensive (average of $343). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated February 3, 2026.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Portland to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Comfort
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Comfort
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Comfort
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Comfort
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Comfort
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Comfort
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Portland to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 3, 2026.
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Portland and Des Moines flights
Browse other Portland and Des Moines flight options. Last updated on February 3, 2026.
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Browse through other flights departing from Portland. Flights are based on user searches made on Cheapflights and were last updated on February 3, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Top 6 airlines flying from Portland to Des Moines
Discover the top 6 airlines that operate flights from Portland to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$81 | Average$194 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$140 | Average$238 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$143 | Average$422 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$251 | Average$475 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$261 | Average$407 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$364 | Average$486 | FlexibilityNo cancel fee | On-time63% |