HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Cuzco

$449+ Cheap flights from Missouri to Cusco (CUZ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/10. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CUZ
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to Cuzco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to Cuzco

Keep the following information in mind while searching for Missouri to Cuzco flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$701
(United)

One-way from

$449
(Kiwi.com)

Popular in

November

Cheapest in

March

Average price

$1,096
Provider with most accurate pricing for Lambert-St Louis-Cusco Velazco Astete flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Cusco Velazco Astete flights.
Search Deals
From Missouri to Cusco Velazco Astete
Search Deals
One-way flight from Missouri to Cusco Velazco Astete
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($77 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($40 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Find flight deals from Missouri to Cuzco

Cheapest flights from Missouri to Cuzco
Explore the most affordable flight options available from Missouri to Cuzco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This KAYAK deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/119:30 amSTL - CUZ
2 stops20h 55mLATAM Airlines
Sun 12/2110:45 pmCUZ - STL
2 stops25h 57mLATAM Airlines
Deal found 10/30$1,001
This KAYAK deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/129:30 amSTL - CUZ
2 stops30h 55mLATAM Airlines
Mon 12/229:45 amCUZ - STL
2 stops24h 13mLATAM Airlines
Deal found 10/30$1,027
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/305:15 amMCI - CUZ
3 stops27h 25mMultiple Airlines
Thu 11/68:27 amCUZ - MCI
3 stops35h 01mMultiple Airlines
Deal found 10/29$1,043
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/105:05 amMCI - CUZ
2 stops24h 21mAmerican Airlines
Sat 1/1712:57 pmCUZ - MCI
2 stops23h 03mAmerican Airlines
Deal found 10/29$1,101
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/811:57 amMCI - CUZ
2 stops18h 29mAmerican Airlines
Wed 12/1010:07 pmCUZ - MCI
2 stops27h 18mAmerican Airlines
Deal found 10/30$1,176
This Expedia deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/145:12 pmSTL - CUZ
2 stops27h 58mLATAM Airlines
Sun 12/2111:20 pmCUZ - STL
2 stops34h 38mLATAM Airlines
Deal found 10/30$1,230
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/94:41 pmSTL - CUZ
2 stops22h 00mAmerican Airlines
Thu 11/137:12 amCUZ - STL
2 stops33h 59mAmerican Airlines
Deal found 10/30$1,240
This Ovago deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/136:00 amSTL - CUZ
3 stops17h 45mLATAM Airlines
Tue 12/237:25 pmCUZ - STL
2 stops14h 33mLATAM Airlines
Deal found 10/30$1,285
This Priceline deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1010:24 amMCI - CUZ
2 stops31h 26mLATAM Airlines
Fri 1/1612:05 amCUZ - MCI
2 stops23h 46mLATAM Airlines
Deal found 10/29$1,446
This Expedia deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/309:50 amMCI - CUZ
2 stops37h 40mLATAM Airlines
Thu 11/612:15 pmCUZ - MCI
2 stops29h 38mLATAM Airlines
Deal found 10/29$2,009

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Cuzco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Missouri to Cusco that are best for you.

Fly from

Missouri

Fly to

Cuzco

Route

Depart

Return

Price

St. LouisCusco

STL - CUZ

STLCUZ

Lambert-St Louis

Tue 3/3

6:00 am-11:20 am

2 stops28h 20m

Cusco Velazco Astete

Tue 3/10

5:10 pm-3:54 pm

2 stops22h 44m

$701

Kansas CityCusco

MCI - CUZ

MCICUZ

Kansas City

Sun 1/25

3:00 pm-11:20 am

2 stops43h 20m

Cusco Velazco Astete

Wed 1/28

12:25 pm-2:11 pm

2 stops26h 46m

$837

St. LouisCusco

STL - CUZ

STLCUZ

Lambert-St Louis

Tue 3/24

11:30 am-6:26 am

2 stops18h 56m

Cusco Velazco Astete

Fri 4/3

5:17 pm-3:42 pm

2 stops22h 25m

$962

Kansas CityCusco

MCI - CUZ

MCICUZ

Kansas City

Sun 1/11

11:40 am-6:56 am

2 stops18h 16m

Cusco Velazco Astete

Sun 1/18

9:02 pm-11:00 am

2 stops14h 58m

$978

St. LouisCusco

STL - CUZ

STLCUZ

Lambert-St Louis

Thu 12/11

6:00 am-12:45 am

2 stops17h 45m

Cusco Velazco Astete

Sun 12/21

10:45 pm-11:42 pm

2 stops25h 57m

$1,001

St. LouisCusco

STL - CUZ

STLCUZ

Lambert-St Louis

Sat 12/13

1:35 pm-5:00 pm

2 stops26h 25m

Cusco Velazco Astete

Tue 12/23

6:50 pm-8:58 am

2 stops15h 08m

$1,027

St. LouisCusco

STL - CUZ

STLCUZ

Lambert-St Louis

Fri 12/12

9:30 am-5:25 pm

2 stops30h 55m

Cusco Velazco Astete

Mon 12/22

7:25 pm-8:58 am

2 stops14h 33m

$1,027

St. LouisCusco

STL - CUZ

STLCUZ

Lambert-St Louis

Tue 1/6

6:00 am-6:15 am

2 stops23h 15m

Cusco Velazco Astete

Tue 1/13

7:35 am-11:39 pm

2 stops17h 04m

$1,043

Kansas CityCusco

MCI - CUZ

MCICUZ

Kansas City

Wed 12/10

5:05 am-6:26 am

2 stops24h 21m

Cusco Velazco Astete

Sat 1/17

12:57 pm-11:00 am

2 stops23h 03m

$1,101

Kansas CityCusco

MCI - CUZ

MCICUZ

Kansas City

Mon 12/8

5:05 am-7:26 am

2 stops25h 21m

Cusco Velazco Astete

Wed 12/10

10:07 pm-12:25 am

2 stops27h 18m

$1,176

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 15 results
1
2

Best time to book a flight from Missouri to Cuzco

Have a flexible travel schedule? Discover the best time to fly to Cuzco from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Cusco

What is the cheapest month to book a flight from Missouri to Cusco?

Currently, December is the cheapest month in which you can book a flight from Missouri to Cusco (average of $748). Flying from Missouri to Cusco in November is currently the most expensive (average of $1,234). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Cuzco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Cusco from Missouri?

    If you book a flight to Cusco from Missouri, you will be flying to Velazco Astete, which is the city’s only airport. Cusco Velazco Astete (CUZ) is located 1.7 mi from the center of Cusco.

  • How long is the flight from Missouri to Cusco?

    For as low as $962, American Airlines can have you in Cusco from Missouri in 18h 56m. The distance between Missouri and Cusco is about 3801 mi.

  • Can I find deals for flights from Missouri to Cuzco that include hotel bookings?

    Yes. In addition to deals on Missouri to Cuzco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Cuzco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Cuzco.

  • Can I find deals for business class flights from Missouri to Cuzco?

    Yes. Cheapflights offers flight deals from Missouri to Cuzco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Cusco?

    Currently, December is the cheapest month in which you can book a flight from Missouri to Cusco (average of $748). Flying from Missouri to Cusco in November is currently the most expensive (average of $1,234). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Cuzco

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Lima flights
Newark to Lima flights
Miami to Lima flights
Los Angeles to Lima flights
LaGuardia to Lima flights
Dulles Intl to Lima flights
Reagan-National to Lima flights
Baltimore to Lima flights
Atlanta to Lima flights
O'Hare Intl to Lima flights
Fort Lauderdale to Lima flights
San Francisco to Lima flights
Orlando to Lima flights
Dallas/Fort Worth to Lima flights
Midway to Lima flights
Boston to Lima flights
Hobby to Lima flights
Tampa to Lima flights
St. Louis to Lima flights
Salt Lake City to Lima flights
Seattle to Lima flights
George Bush Intcntl to Lima flights
Charlotte to Lima flights
Denver to Lima flights
Ontario to Lima flights
Love Field to Lima flights
Detroit to Lima flights
Austin to Lima flights
Minneapolis to Lima flights
Raleigh to Lima flights
Jacksonville to Lima flights
John F Kennedy Intl to Cuzco flights
West Palm Beach to Lima flights
Hartford to Lima flights
Philadelphia to Lima flights
Newark to Cuzco flights
Cincinnati to Lima flights
Sky Harbor Intl to Lima flights
Las Vegas to Lima flights
San Jose to Lima flights
Los Angeles to Cuzco flights
San Diego to Lima flights
LaGuardia to Cuzco flights
Portland to Lima flights
Seattle to Cuzco flights
O'Hare Intl to Cuzco flights
Sacramento to Lima flights
Boston to Cuzco flights
Dallas/Fort Worth to Cuzco flights

Top 2 airlines flying from Missouri to Cuzco

Discover the top 2 airlines that operate flights from Missouri to Cuzco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$733Average$1,232FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$776Average$1,014FlexibilityNo cancel feeOn-time81%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.