$111+ Cheap flights from Des Moines (DSM) to Columbus
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CMH
May 28 — Jun 41
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Columbus with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
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Cheapest flights from Des Moines to ColumbusExplore the most affordable flight options available from Des Moines to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.
Explore the most affordable flight options available from Des Moines to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:15 am
DSM
- CMH
1 stop6h 10m
Delta
Wed 6/107:01 am
CMH
- DSM
1 stop4h 42m
Delta
Deal found 4/23![Delta logo]()
$221
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:30 am
DSM
- CMH
2 stops6h 10m
Southwest
Wed 6/107:50 pm
CMH
- DSM
1 stop3h 55m
Southwest
Deal found 4/23![Southwest logo]()
$236
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2311:57 am
DSM
- CMH
1 stop6h 46m
Delta
Tue 5/2610:47 am
CMH
- DSM
1 stop7h 19m
Delta
Deal found 4/23![Delta logo]()
$243
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:30 am
DSM
- CMH
2 stops11h 50m
Southwest
Thu 5/288:00 pm
CMH
- DSM
1 stop4h 05m
Southwest
Deal found 4/23![Southwest logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:45 am
DSM
- CMH
1 stop15h 11m
Multiple Airlines
Sun 5/177:20 pm
CMH
- DSM
2 stops19h 11m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$287
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:41 pm
DSM
- CMH
1 stop4h 49m
Delta
Wed 6/105:01 pm
CMH
- DSM
1 stop6h 30m
Delta
Deal found 4/23![Delta logo]()
$290
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/181:40 pm
DSM
- CMH
1 stop8h 11m
United Airlines
Wed 8/197:00 am
CMH
- DSM
1 stop4h 11m
United Airlines
Deal found 4/23![United Airlines logo]()
$296
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:00 am
DSM
- CMH
1 stop5h 21m
American Airlines
Wed 5/206:58 am
CMH
- DSM
1 stop7h 13m
American Airlines
Deal found 4/27![American Airlines logo]()
$319
Best flights from Des Moines to ColumbusDiscover carefully curated flight deals from Des Moines to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 28, 2026.
Discover carefully curated flight deals from Des Moines to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 28, 2026.
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:30 am
DSM
- CMH
2 stops6h 10m
Southwest
Wed 6/107:50 pm
CMH
- DSM
1 stop3h 55m
Southwest
Deal found 4/23![Southwest logo]()
$236
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2311:57 am
DSM
- CMH
1 stop6h 46m
Delta
Tue 5/2610:47 am
CMH
- DSM
1 stop7h 19m
Delta
Deal found 4/23![Delta logo]()
$243
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/181:40 pm
DSM
- CMH
1 stop8h 11m
United Airlines
Wed 8/197:00 am
CMH
- DSM
1 stop4h 11m
United Airlines
Deal found 4/23![United Airlines logo]()
$296
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:41 pm
DSM
- CMH
1 stop4h 49m
Delta
Wed 6/105:01 pm
CMH
- DSM
1 stop6h 30m
Delta
Deal found 4/23![Delta logo]()
$290
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:10 am
DSM
- CMH
2 stops10h 45m
Southwest
Wed 6/105:40 am
CMH
- DSM
2 stops6h 50m
Southwest
Deal found 4/23![Southwest logo]()
$335
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:56 pm
DSM
- CMH
1 stop4h 56m
Delta
Sun 5/177:09 am
CMH
- DSM
1 stop6h 15m
Delta
Deal found 4/23![Delta logo]()
$362
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/181:04 pm
DSM
- CMH
1 stop4h 57m
Delta
Fri 5/2212:55 pm
CMH
- DSM
1 stop5h 58m
Delta
Deal found 4/26![Delta logo]()
$377
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/122:25 pm
DSM
- CMH
1 stop6h 06m
Delta
Fri 6/192:00 pm
CMH
- DSM
1 stop3h 54m
Delta
Deal found 4/27![Delta logo]()
$387
Last-minute flights from Des Moines to ColumbusDiscover last-minute flight deals from Des Moines to Columbus. Data last updated April 28, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Columbus. Data last updated April 28, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:45 am
DSM
- CMH
1 stop15h 11m
Multiple Airlines
Sun 5/177:20 pm
CMH
- DSM
2 stops19h 11m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$287
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:56 pm
DSM
- CMH
1 stop4h 56m
Delta
Sun 5/177:09 am
CMH
- DSM
1 stop6h 15m
Delta
Deal found 4/23![Delta logo]()
$362
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:45 am
DSM
- CMH
2 stops35h 08m
Multiple Airlines
Fri 5/226:00 am
CMH
- DSM
1 stop18h 24m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$360
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/185:01 pm
DSM
- CMH
1 stop5h 21m
American Airlines
Fri 5/225:30 am
CMH
- DSM
1 stop3h 43m
American Airlines
Deal found 4/23![American Airlines logo]()
$376
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/181:04 pm
DSM
- CMH
1 stop4h 57m
Delta
Fri 5/227:09 am
CMH
- DSM
1 stop6h 15m
Delta
Deal found 4/24![Delta logo]()
$377
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:00 am
DSM
- CMH
1 stop5h 21m
American Airlines
Wed 5/206:58 am
CMH
- DSM
1 stop7h 13m
American Airlines
Deal found 4/27![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:40 am
DSM
- CMH
1 stop4h 11m
United Airlines
Wed 5/207:00 am
CMH
- DSM
2 stops8h 24m
United Airlines
Deal found 4/27![United Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/221:04 pm
DSM
- CMH
1 stop4h 57m
Delta
Fri 5/297:09 am
CMH
- DSM
1 stop4h 07m
Delta
Deal found 4/23![Delta logo]()
$357
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2311:57 am
DSM
- CMH
1 stop6h 46m
Delta
Tue 5/2610:47 am
CMH
- DSM
1 stop7h 19m
Delta
Deal found 4/23![Delta logo]()
$243
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:30 am
DSM
- CMH
2 stops11h 50m
Southwest
Thu 5/288:00 pm
CMH
- DSM
1 stop4h 05m
Southwest
Deal found 4/23![Southwest logo]()
$282
One-way flights from Des Moines to ColumbusSearch for one-way flight options from Des Moines to Columbus. Find affordable one-way fares based on user searches. Data last updated April 28, 2026.
Search for one-way flight options from Des Moines to Columbus. Find affordable one-way fares based on user searches. Data last updated April 28, 2026.
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2611:57 am
DSM
- CMH
1 stop4h 52m
Delta
Deal found 4/23![Delta logo]()
$111
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:30 am
DSM
- CMH
2 stops11h 50m
Southwest
Deal found 4/23![Southwest logo]()
$131
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:00 am
DSM
- CMH
1 stop3h 57m
United Airlines
Deal found 4/23![United Airlines logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- CMH
2 stops25h 54m
Frontier
Deal found 4/27![Frontier logo]()
$142
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:08 am
DSM
- CMH
1 stop4h 19m
Delta
Deal found 4/26![Delta logo]()
$160
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/165:00 am
DSM
- CMH
2 stops8h 12m
United Airlines
Deal found 4/27![United Airlines logo]()
$165
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:25 am
DSM
- CMH
1 stop5h 23m
Delta
Deal found 4/23![Delta logo]()
$169
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:00 am
DSM
- CMH
2 stops7h 12m
United Airlines
Deal found 4/23![United Airlines logo]()
$174
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:48 pm
DSM
- CMH
3 stops45h 22m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$184
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:20 am
DSM
- CMH
2 stops7h 00m
Southwest
Deal found 4/26![Southwest logo]()
$188
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/185:01 pm
DSM
- CMH
1 stop5h 21m
American Airlines
Deal found 4/27![American Airlines logo]()
$192
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/206:08 am
DSM
- CMH
1 stop6h 19m
Delta
Deal found 4/28![Delta logo]()
$194
Find flight deals from Des Moines to Columbus
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Columbus (C01). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 28, 2026.
Round-trip from | $221 (Delta) |
|---|---|
One-way from | $111 (Delta) |
Popular in | August |
Cheapest in | June |
Average price | $484 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Columbus that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
Use the filters below to find and compare flights from Des Moines to Columbus that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesColumbus
DSM - CMH
DSMCMH
Des Moines
Wed 6/3
5:30 am-12:40 pm
2 stops6h 10m
Columbus
Wed 6/10
7:50 pm-10:45 pm
1 stop3h 55m
$236
Des MoinesColumbus
DSM - CMH
DSMCMH
Des Moines
Sat 5/23
11:57 am-7:43 pm
1 stop6h 46m
Columbus
Tue 5/26
10:47 am-5:06 pm
1 stop7h 19m
$243
Des MoinesColumbus
DSM - CMH
DSMCMH
Des Moines
Thu 6/4
6:41 pm-12:30 am
1 stop4h 49m
Columbus
Wed 6/10
5:01 pm-10:31 pm
1 stop6h 30m
$290
Des MoinesColumbus
DSM - CMH
DSMCMH
Des Moines
Tue 8/18
1:40 pm-10:51 pm
1 stop8h 11m
Columbus
Wed 8/19
7:00 am-10:11 am
1 stop4h 11m
$296
Des MoinesColumbus
DSM - CMH
DSMCMH
Des Moines
Thu 6/4
5:10 am-4:55 pm
2 stops10h 45m
Columbus
Wed 6/10
5:40 am-11:30 am
2 stops6h 50m
$335
Des MoinesColumbus
DSM - CMH
DSMCMH
Des Moines
Thu 5/14
5:56 pm-11:52 pm
1 stop4h 56m
Columbus
Sun 5/17
7:09 am-12:24 pm
1 stop6h 15m
$362
Des MoinesColumbus
DSM - CMH
DSMCMH
Des Moines
Mon 5/18
1:04 pm-7:01 pm
1 stop4h 57m
Columbus
Fri 5/22
12:55 pm-5:53 pm
1 stop5h 58m
$377
Quickest round-trip
Des MoinesColumbus
DSM - CMH
DSMCMH
Des Moines
Fri 6/12
2:25 pm-9:31 pm
1 stop6h 06m
Columbus
Fri 6/19
2:00 pm-4:54 pm
1 stop3h 54m
$387
Cheapest one-way
Quickest one-way
Des MoinesColumbus
DSM - CMH
DSMCMH
Des Moines
Thu 6/4
5:00 am-9:57 am
1 stop3h 57m
$133
Des MoinesColumbus
DSM - CMH
DSMCMH
Des Moines
Mon 6/1
2:16 pm-5:10 pm
2 stops25h 54m
$142
Showing 1-10 of 17 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Columbus
Have a flexible travel schedule? Discover the best time to fly to Columbus from Des Moines with our price prediction graph.
DSM-C01
DSM-CMH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Columbus
DSM-C01
DSM-CMH
What is the cheapest month to book a flight from Des Moines to Columbus?
Currently, July is the cheapest month in which you can book a flight from Des Moines to Columbus (average of $243). Flying from Des Moines to Columbus in January is currently the most expensive (average of $392). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Columbus?
Reviews of airlines servicing Columbus
Get insights into the airlines that provide service to Columbus. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Columbus. Reviews last updated April 28, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to Columbus to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Overall
8.0
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Overall
8.0
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Overall
8.0
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Overall
8.0
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Overall
8.0
Food
7.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Columbus. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Columbus
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Find flights from Des Moines to Columbus, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Columbus flights
Browse other Des Moines and Columbus flight options. Last updated on April 28, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on April 28, 2026.
Popular flight searches
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Top 4 airlines flying from Des Moines to Columbus
Discover the top 4 airlines that operate flights from Des Moines to Columbus. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$197 | Average$372 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$250 | Average$385 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$250 | Average$501 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$260 | Average$386 | FlexibilityNo cancel fee | On-time63% |