$155+ Cheap flights from Des Moines (DSM) to Columbus
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/8. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CMH
Oct 9 — Oct 161
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Columbus with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Columbus
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Best
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Cheapest flights from Des Moines to ColumbusExplore the most affordable flight options available from Des Moines to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
Explore the most affordable flight options available from Des Moines to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:55 pm -
1 stop3h 59m
Wed 10/147:17 am -
1 stop4h 14m
Deal found 9/8![United Airlines logo]()
$304
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/174:07 pm -
1 stop6h 33m
Sat 10/244:24 pm -
1 stop5h 36m
Deal found 9/8![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:50 am -
1 stop3h 20m
Sat 10/316:55 am -
2 stops11h 50m
Deal found 9/9![Southwest logo]()
$320
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop6h 14m
Fri 10/237:17 am -
1 stop4h 14m
Deal found 9/9![United Airlines logo]()
$327
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:54 pm -
1 stop4h 50m
Mon 10/127:10 am -
1 stop4h 01m
Deal found 9/8![Delta logo]()
$332
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:35 am -
2 stops6h 05m
Fri 10/238:20 pm -
1 stop3h 55m
Deal found 9/9![Southwest logo]()
$337
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/247:07 am -
1 stop6h 09m
Wed 12/28:29 pm -
1 stop4h 57m
Deal found 9/5![American Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:10 am -
1 stop4h 25m
Wed 12/25:40 am -
2 stops6h 45m
Deal found 9/5![Southwest logo]()
$352
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:35 am -
1 stop5h 10m
Thu 10/226:30 am -
1 stop7h 50m
Deal found 9/6![Southwest logo]()
$362
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:29 am -
1 stop5h 03m
Sat 10/247:40 pm -
1 stop5h 34m
Deal found 9/5![American Airlines logo]()
$363
Best flights from Des Moines to ColumbusDiscover carefully curated flight deals from Des Moines to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
Discover carefully curated flight deals from Des Moines to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:00 am -
1 stop3h 30m
Wed 11/188:40 am -
1 stop3h 45m
Deal found 9/6![Southwest logo]()
$362
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:54 pm -
1 stop4h 50m
Mon 10/127:10 am -
1 stop4h 01m
Deal found 9/7![Delta logo]()
$377
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:23 am -
1 stop4h 43m
Sun 11/85:40 am -
1 stop4h 06m
Deal found 9/4![American Airlines logo]()
$387
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1711:27 am -
1 stop4h 38m
Sat 10/2412:36 pm -
2 stops9h 25m
Deal found 9/6![United Airlines logo]()
$462
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/24:30 pm -
1 stop3h 20m
Sun 10/48:15 pm -
1 stop3h 40m
Deal found 9/5![Southwest logo]()
$387
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:54 pm -
1 stop4h 50m
Sun 10/116:00 am -
1 stop5h 42m
Deal found 9/4![Delta logo]()
$407
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:35 am -
2 stops6h 10m
Thu 10/223:50 pm -
2 stops7h 20m
Deal found 9/6![Southwest logo]()
$409
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:54 pm -
1 stop4h 50m
Mon 10/196:25 am -
1 stop4h 17m
Deal found 9/6![Delta logo]()
$438
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/162:00 pm -
1 stop10h 05m
Fri 10/233:50 pm -
2 stops7h 20m
Deal found 9/8![Southwest logo]()
$429
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/56:45 am -
1 stop7h 20m
Sun 3/76:20 am -
2 stops9h 10m
Deal found 9/9![Southwest logo]()
$462
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:30 pm -
1 stop3h 20m
Mon 10/125:50 am -
2 stops6h 20m
Deal found 9/7![Southwest logo]()
$468
Last-minute flights from Des Moines to ColumbusDiscover last-minute flight deals from Des Moines to Columbus. Data last updated September 9, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Columbus. Data last updated September 9, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:54 pm -
1 stop4h 50m
Mon 10/127:10 am -
1 stop4h 01m
Deal found 9/8![Delta logo]()
$332
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:50 pm -
1 stop5h 08m
Sun 10/116:25 am -
1 stop4h 17m
Deal found 9/8![Delta logo]()
$376
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:55 pm -
1 stop3h 59m
Wed 10/147:17 am -
1 stop4h 14m
Deal found 9/8![United Airlines logo]()
$304
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/174:07 pm -
1 stop6h 33m
Sat 10/244:24 pm -
1 stop5h 36m
Deal found 9/8![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:29 am -
1 stop5h 03m
Sat 10/247:40 pm -
1 stop5h 34m
Deal found 9/5![American Airlines logo]()
$363
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:35 am -
1 stop5h 10m
Thu 10/226:30 am -
1 stop7h 50m
Deal found 9/6![Southwest logo]()
$362
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop6h 14m
Fri 10/237:17 am -
1 stop4h 14m
Deal found 9/9![United Airlines logo]()
$327
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:35 am -
2 stops6h 05m
Fri 10/238:20 pm -
1 stop3h 55m
Deal found 9/9![Southwest logo]()
$337
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:50 am -
1 stop3h 20m
Sat 10/316:55 am -
2 stops11h 50m
Deal found 9/9![Southwest logo]()
$320
One-way flights from Des Moines to ColumbusSearch for one-way flight options from Des Moines to Columbus. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
Search for one-way flight options from Des Moines to Columbus. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:54 pm -
1 stop4h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Delta logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/253:04 pm -
2 stops26h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$170
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:54 pm -
1 stop4h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Delta logo]()
$178
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:54 pm -
1 stop4h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Delta logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/183:04 pm -
2 stops26h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$190
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/88:00 am -
1 stop4h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![United Airlines logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:30 pm -
2 stops21h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Frontier logo]()
$200
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:45 pm -
1 stop3h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/5![United Airlines logo]()
$209
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:57 pm -
1 stop5h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![American Airlines logo]()
$239
Find flight deals from Des Moines to Columbus
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Columbus (C01). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 9, 2026.
Round-trip from | $304 (United Airlines) |
|---|---|
One-way from | $155 (Delta) |
Popular in | January |
Cheapest in | April |
Average price | $486 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Columbus that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
Use the filters below to find and compare flights from Des Moines to Columbus that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesColumbus
DSM Des Moines - CMH Columbus
DSMCMH
Des Moines
Fri 10/9
6:54 pm-12:44 am
1 stop4h 50m
Columbus
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$178
Des MoinesColumbus
DSM Des Moines - CMH Columbus
DSMCMH
Des Moines
Thu 10/8
6:54 pm-12:44 am
1 stop4h 50m
Columbus
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$189
Des MoinesColumbus
DSM Des Moines - CMH Columbus
DSMCMH
Des Moines
Mon 10/5
6:54 pm-12:15 am
1 stop4h 21m
Columbus
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$189
Quickest round-trip
Des MoinesColumbus
DSM Des Moines - CMH Columbus
DSMCMH
Des Moines
Thu 10/8
8:00 am-1:14 pm
1 stop4h 14m
Columbus
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$195
Des MoinesColumbus
DSM Des Moines - CMH Columbus
DSMCMH
Des Moines
Mon 11/30
5:10 am-4:35 pm
2 stops10h 25m
Columbus
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$244
Des MoinesColumbus
DSM Des Moines - CMH Columbus
DSMCMH
Des Moines
Mon 11/16
6:00 am-10:30 am
1 stop3h 30m
Columbus
Wed 11/18
8:40 am-11:25 am
1 stop3h 45m
$362
Des MoinesColumbus
DSM Des Moines - CMH Columbus
DSMCMH
Des Moines
Fri 10/9
6:54 pm-12:44 am
1 stop4h 50m
Columbus
Mon 10/12
7:10 am-10:11 am
1 stop4h 01m
$377
Des MoinesColumbus
DSM Des Moines - CMH Columbus
DSMCMH
Des Moines
Fri 9/18
3:04 pm-6:43 pm
3 stops26h 39m
Columbus
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$380
Des MoinesColumbus
DSM Des Moines - CMH Columbus
DSMCMH
Des Moines
Thu 11/5
7:23 am-1:06 pm
1 stop4h 43m
Columbus
Sun 11/8
5:40 am-8:46 am
1 stop4h 06m
$387
Des MoinesColumbus
DSM Des Moines - CMH Columbus
DSMCMH
Des Moines
Fri 10/2
4:30 pm-8:50 pm
1 stop3h 20m
Columbus
Sun 10/4
8:15 pm-10:55 pm
1 stop3h 40m
$387
Showing 1-10 of 17 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Columbus
Have a flexible travel schedule? Discover the best time to fly to Columbus from Des Moines with our price prediction graph.
DSM-C01
DSM-CMH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Columbus
DSM-C01
DSM-CMH
What is the cheapest month to book a flight from Des Moines to Columbus?
Currently, April is the cheapest month in which you can book a flight from Des Moines to Columbus (average of $289). Flying from Des Moines to Columbus in January is currently the most expensive (average of $577). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Columbus?
Airfare is typical for this route at the moment.
Des Moines to Columbus flights typically cost between $302 and $501 in October.The cheapest round-trip price found within the last 5 days was $304 on United Airlines (Oct 12-Oct 14).
Reviews of airlines servicing Columbus
Get insights into the airlines that provide service to Columbus. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Columbus. Reviews last updated September 9, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to Columbus to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Overall
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Comfort
8.0
Overall
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Comfort
8.0
Overall
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Comfort
8.0
Overall
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Columbus. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
Complete your trip to Columbus by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Columbus by cabin class
Find flights from Des Moines to Columbus, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Columbus flights
Browse other Des Moines and Columbus flight options. Last updated on September 9, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on September 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Columbus
Discover the top 3 airlines that operate flights from Des Moines to Columbus. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$225 | Average$386 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$284 | Average$418 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$296 | Average$402 | FlexibilityNo cancel fee | On-time63% |