$153+ Cheap flights from Knoxville (TYS) to Columbus
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CMH
Oct 17 — Oct 241
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Knoxville to ColumbusExplore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
Explore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:23 pm -
1 stop6h 21m
Mon 10/193:00 pm -
1 stop3h 47m
Deal found 9/16![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:25 pm -
1 stop3h 25m
Mon 10/1912:40 pm -
2 stops10h 05m
Deal found 9/16![Southwest logo]()
$268
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:58 pm -
1 stop4h 23m
Fri 10/237:04 pm -
1 stop4h 55m
Deal found 9/15![American Airlines logo]()
$303
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:00 am -
1 stop7h 14m
Sun 10/186:02 am -
1 stop4h 35m
Deal found 9/16![United Airlines logo]()
$306
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:45 am -
1 stop4h 57m
Mon 11/27:56 pm -
1 stop4h 03m
Deal found 9/16![United Airlines logo]()
$327
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:48 am -
1 stop5h 02m
Fri 11/68:20 pm -
1 stop3h 38m
Deal found 9/14![American Airlines logo]()
$333
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:06 pm -
1 stop6h 15m
Mon 10/196:00 am -
1 stop4h 25m
Deal found 9/14![American Airlines logo]()
$345
Best flights from Knoxville to ColumbusDiscover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
Discover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/152:38 pm -
1 stop3h 31m
Mon 10/191:07 pm -
1 stop4h 21m
Deal found 9/15![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:25 pm -
1 stop3h 25m
Mon 10/1912:40 pm -
2 stops10h 05m
Deal found 9/15![Southwest logo]()
$268
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:45 am -
1 stop4h 57m
Mon 11/27:56 pm -
1 stop4h 03m
Deal found 9/14![United Airlines logo]()
$327
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:06 pm -
1 stop6h 15m
Mon 10/196:00 am -
1 stop4h 25m
Deal found 9/14![American Airlines logo]()
$345
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:33 am -
1 stop3h 49m
Mon 10/57:05 am -
1 stop4h 13m
Deal found 9/16![Delta logo]()
$362
This Southwest deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:10 am -
2 stops9h 15m
Sun 12/68:45 am -
2 stops11h 45m
Deal found 9/12![Southwest logo]()
$372
Last-minute flights from Knoxville to ColumbusDiscover last-minute flight deals from Knoxville to Columbus. Data last updated September 17, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Columbus. Data last updated September 17, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:06 pm -
1 stop6h 15m
Mon 10/196:00 am -
1 stop4h 25m
Deal found 9/14![American Airlines logo]()
$345
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:23 pm -
1 stop6h 21m
Mon 10/193:00 pm -
1 stop3h 47m
Deal found 9/16![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:25 pm -
1 stop3h 25m
Mon 10/1912:40 pm -
2 stops10h 05m
Deal found 9/16![Southwest logo]()
$268
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:00 am -
1 stop7h 14m
Sun 10/186:02 am -
1 stop4h 35m
Deal found 9/16![United Airlines logo]()
$306
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:58 pm -
1 stop4h 23m
Fri 10/237:04 pm -
1 stop4h 55m
Deal found 9/15![American Airlines logo]()
$303
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:45 am -
1 stop4h 57m
Mon 11/27:56 pm -
1 stop4h 03m
Deal found 9/16![United Airlines logo]()
$327
One-way flights from Knoxville to ColumbusSearch for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
Search for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:33 pm -
1 stop26h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Multiple Airlines logo]()
$153
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:55 pm -
1 stop4h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![American Airlines logo]()
$171
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:06 pm -
1 stop6h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![American Airlines logo]()
$173
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/257:45 pm -
1 stop4h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Delta logo]()
$184
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:45 am -
1 stop4h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![United Airlines logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:14 pm -
2 stops22h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/257:00 am -
2 stops32h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/83:08 pm -
3 stops27h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Multiple Airlines logo]()
$261
Find flight deals from Knoxville to Columbus
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Columbus (C01). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2026.
Round-trip from | $257 (Delta) |
|---|---|
One-way from | $153 (Kiwi.com) |
Popular in | June |
Cheapest in | October |
Average price | $343 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Columbus that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
Use the filters below to find and compare flights from Knoxville to Columbus that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Sun 11/15
6:33 pm-9:14 pm
1 stop26h 41m
Columbus
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$153
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Thu 10/8
6:06 pm-12:21 am
1 stop6h 15m
Columbus
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$173
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Thu 10/8
6:15 am-6:48 pm
2 stops12h 33m
Columbus
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$173
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Mon 10/5
6:55 pm-11:24 pm
1 stop4h 29m
Columbus
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$176
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Sun 10/25
7:45 pm-12:44 am
1 stop4h 59m
Columbus
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$184
Quickest round-trip
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Sun 10/25
5:45 am-9:55 am
1 stop4h 10m
Columbus
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$203
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Mon 10/5
8:14 pm-6:55 pm
2 stops22h 41m
Columbus
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$213
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Sun 10/25
7:00 am-3:32 pm
2 stops32h 32m
Columbus
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$246
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Thu 10/15
2:38 pm-6:09 pm
1 stop3h 31m
Columbus
Mon 10/19
1:07 pm-5:28 pm
1 stop4h 21m
$257
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Thu 10/15
7:25 pm-10:50 pm
1 stop3h 25m
Columbus
Mon 10/19
12:40 pm-10:45 pm
2 stops10h 05m
$268
Showing 1-10 of 16 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Columbus
Have a flexible travel schedule? Discover the best time to fly to Columbus from Knoxville with our price prediction graph.
TYS-C01
TYS-CMH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Columbus
TYS-C01
TYS-CMH
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Columbus
Get insights into the airlines that provide service to Columbus. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Columbus. Reviews last updated September 17, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Columbus. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.8
Crew
8.5
Overall
7.8
Comfort
7.8
Food
7.2
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Boarding
8.1
Entertainment
7.8
Crew
8.5
Overall
7.8
Comfort
7.8
Food
7.2
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Boarding
8.1
Entertainment
7.8
Crew
8.5
Overall
7.8
Comfort
7.8
Food
7.2
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Columbus. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Columbus by adding a car rental and/or hotel reservation to your travel itinerary.
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Knoxville and Columbus flights
Browse other Knoxville and Columbus flight options. Last updated on September 17, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on September 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Columbus
Discover the top 2 airlines that operate flights from Knoxville to Columbus. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$394 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$268 | Average$361 | FlexibilityNo cancel fee | On-timeN/A |