$111+ Cheap flights from Knoxville (TYS) to Columbus
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/18. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CMH
Dec 2 — Dec 91
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Knoxville to Columbus with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Columbus
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to ColumbusExplore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2026.
Explore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/410:55 am -
1 stop25h 49m
Thu 11/121:29 pm -
1 stop9h 08m
Deal found 10/29![Multiple Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/71:58 pm -
2 stops22h 00m
Fri 12/111:24 pm -
1 stop21h 13m
Deal found 10/29![Multiple Airlines logo]()
$253
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/77:24 pm -
1 stop4h 34m
Fri 12/118:11 pm -
1 stop3h 48m
Deal found 10/29![American Airlines logo]()
$256
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/202:47 pm -
1 stop5h 30m
Sun 11/226:00 am -
1 stop3h 55m
Deal found 10/28![Delta logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/108:30 am -
2 stops33h 57m
Thu 11/121:29 pm -
1 stop9h 08m
Deal found 10/30![Multiple Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/410:55 am -
1 stop25h 49m
Wed 11/117:22 pm -
2 stops27h 15m
Deal found 10/29![Multiple Airlines logo]()
$361
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2011:45 am -
2 stops6h 55m
Sun 11/225:35 pm -
1 stop4h 10m
Deal found 10/28![Southwest logo]()
$394
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/77:05 am -
2 stops11h 40m
Fri 12/116:55 am -
2 stops13h 40m
Deal found 10/29![Southwest logo]()
$404
Best flights from Knoxville to ColumbusDiscover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 2, 2026.
Discover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 2, 2026.
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/77:24 pm -
1 stop4h 34m
Fri 12/118:11 pm -
1 stop3h 48m
Deal found 10/29![American Airlines logo]()
$256
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/17:55 am -
1 stop10h 15m
Mon 1/45:35 pm -
1 stop4h 10m
Deal found 10/29![Southwest logo]()
$278
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/202:47 pm -
1 stop5h 30m
Sun 11/226:00 am -
1 stop3h 55m
Deal found 10/29![Delta logo]()
$303
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/197:35 pm -
1 stop4h 09m
Sun 2/218:05 pm -
1 stop3h 54m
Deal found 10/28![United Airlines logo]()
$315
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/197:40 am -
2 stops13h 35m
Sun 2/216:20 am -
1 stop5h 35m
Deal found 10/28![Southwest logo]()
$326
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/77:05 am -
2 stops11h 40m
Fri 12/116:55 am -
2 stops13h 40m
Deal found 10/29![Southwest logo]()
$404
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/144:00 pm -
1 stop5h 08m
Wed 11/181:06 pm -
1 stop5h 43m
Deal found 10/30![Delta logo]()
$487
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2011:45 am -
2 stops6h 55m
Sun 11/226:55 am -
2 stops13h 40m
Deal found 10/29![Southwest logo]()
$461
Last-minute flights from Knoxville to ColumbusDiscover last-minute flight deals from Knoxville to Columbus. Data last updated November 2, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Columbus. Data last updated November 2, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/410:55 am -
1 stop25h 49m
Thu 11/121:29 pm -
1 stop9h 08m
Deal found 10/29![Multiple Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/410:55 am -
1 stop25h 49m
Wed 11/117:22 pm -
2 stops27h 15m
Deal found 10/29![Multiple Airlines logo]()
$361
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/108:30 am -
2 stops33h 57m
Thu 11/121:29 pm -
1 stop9h 08m
Deal found 10/30![Multiple Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals ”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:52 am -
1 stop6h 24m
Mon 11/166:42 pm -
1 stop4h 06m
Deal found 10/28![American Airlines logo]()
$487
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:10 am -
1 stop4h 05m
Mon 11/166:20 am -
2 stops6h 00m
Deal found 10/28![Southwest logo]()
$492
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/202:47 pm -
1 stop5h 30m
Sun 11/226:00 am -
1 stop3h 55m
Deal found 10/29![Delta logo]()
$303
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2011:45 am -
2 stops6h 55m
Sun 11/226:00 am -
1 stop4h 40m
Deal found 10/29![Southwest logo]()
$394
One-way flights from Knoxville to ColumbusSearch for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated November 2, 2026.
Search for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated November 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:17 pm -
1 stop18h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Multiple Airlines logo]()
$111
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/181:00 pm -
2 stops8h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Southwest logo]()
$249
Find flight deals from Knoxville to Columbus
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Columbus (C01). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 2, 2026.
Round-trip from | $253 (Kiwi.com) |
|---|---|
One-way from | $111 (Kiwi.com) |
Popular in | June |
Cheapest in | May |
Average price | $446 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Columbus that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 2, 2026.
Use the filters below to find and compare flights from Knoxville to Columbus that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Wed 11/18
6:17 pm-12:31 pm
1 stop18h 14m
Columbus
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$111
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Wed 11/18
1:00 pm-9:15 pm
2 stops8h 15m
Columbus
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$249
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Mon 12/7
7:24 pm-11:58 pm
1 stop4h 34m
Columbus
Fri 12/11
8:11 pm-11:59 pm
1 stop3h 48m
$256
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 1/1
7:55 am-6:10 pm
1 stop10h 15m
Columbus
Mon 1/4
5:35 pm-9:45 pm
1 stop4h 10m
$278
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 11/20
2:47 pm-8:17 pm
1 stop5h 30m
Columbus
Sun 11/22
6:00 am-9:55 am
1 stop3h 55m
$303
Quickest round-trip
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 2/19
7:35 pm-11:44 pm
1 stop4h 09m
Columbus
Sun 2/21
8:05 pm-11:59 pm
1 stop3h 54m
$315
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 2/19
7:40 am-9:15 pm
2 stops13h 35m
Columbus
Sun 2/21
6:20 am-11:55 am
1 stop5h 35m
$326
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Mon 12/7
7:05 am-6:45 pm
2 stops11h 40m
Columbus
Fri 12/11
6:55 am-8:35 pm
2 stops13h 40m
$404
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 11/20
11:45 am-6:40 pm
2 stops6h 55m
Columbus
Sun 11/22
6:55 am-8:35 pm
2 stops13h 40m
$461
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Sat 11/14
4:00 pm-9:08 pm
1 stop5h 08m
Columbus
Wed 11/18
1:06 pm-6:49 pm
1 stop5h 43m
$487
Sorted by cheapest first
Best time to book a flight from Knoxville to Columbus
Have a flexible travel schedule? Discover the best time to fly to Columbus from Knoxville with our price prediction graph.
TYS-C01
TYS-CMH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Columbus
TYS-C01
TYS-CMH
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Columbus
Get insights into the airlines that provide service to Columbus. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Columbus. Reviews last updated November 2, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Columbus. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.8
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.8
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.8
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Columbus. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Knoxville
Popular flights
Alternative routes for Knoxville to Columbus
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Columbus by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Columbus by cabin class
Find flights from Knoxville to Columbus, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Columbus flights
Browse other Knoxville and Columbus flight options. Last updated on November 2, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on November 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Columbus
Discover the top 2 airlines that operate flights from Knoxville to Columbus. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$456 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$272 | Average$361 | FlexibilityNo cancel fee | On-timeN/A |