$129+ Cheap flights from Knoxville (TYS) to Columbus
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CMH
Sep 4 — Sep 111
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Knoxville to ColumbusExplore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 5, 2026.
Explore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/179:08 pm -
1 stop12h 35m
Tue 8/186:10 pm -
2 stops20h 49m
Deal found 7/31![Multiple Airlines logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/135:44 pm -
2 stops25h 11m
Sun 9/209:16 pm -
1 stop23h 23m
Deal found 7/31![Multiple Airlines logo]()
$298
This United Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/229:45 am -
1 stop4h 33m
Thu 9/245:20 am -
1 stop4h 26m
Deal found 8/2![United Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:45 am -
1 stop3h 59m
Tue 10/65:20 am -
1 stop4h 25m
Deal found 8/5![United Airlines logo]()
$314
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:10 am -
2 stops9h 50m
Sat 8/293:20 pm -
1 stop4h 00m
Deal found 8/4![Southwest logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:55 am -
1 stop7h 10m
Sun 11/154:34 pm -
2 stops26h 27m
Deal found 8/3![Multiple Airlines logo]()
$323
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:30 am -
1 stop6h 22m
Fri 8/286:00 am -
1 stop3h 36m
Deal found 7/31![Delta logo]()
$325
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:40 am -
2 stops7h 25m
Mon 10/193:50 pm -
2 stops6h 50m
Deal found 8/2![Southwest logo]()
$335
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:25 pm -
1 stop4h 34m
Sun 9/276:02 am -
1 stop4h 35m
Deal found 8/5![United Airlines logo]()
$336
Best flights from Knoxville to ColumbusDiscover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 5, 2026.
Discover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 5, 2026.
This United Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/229:45 am -
1 stop4h 33m
Thu 9/245:20 am -
1 stop4h 26m
Deal found 8/2![United Airlines logo]()
$308
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:40 am -
1 stop6h 22m
Tue 10/67:00 am -
1 stop3h 54m
Deal found 8/3![Delta logo]()
$314
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:00 am -
1 stop4h 08m
Sun 9/206:38 am -
1 stop5h 52m
Deal found 7/31![American Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:10 am -
2 stops8h 35m
Sun 11/156:00 am -
2 stops10h 50m
Deal found 8/3![Southwest logo]()
$367
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:45 am -
1 stop3h 59m
Tue 10/65:20 am -
1 stop4h 25m
Deal found 8/5![United Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:30 am -
1 stop6h 22m
Fri 8/286:00 am -
1 stop3h 36m
Deal found 7/31![Delta logo]()
$325
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/228:05 am -
1 stop4h 20m
Thu 9/248:05 am -
2 stops11h 05m
Deal found 8/2![Southwest logo]()
$386
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/307:00 am -
2 stops7h 05m
Wed 2/37:00 am -
1 stop6h 18m
Deal found 7/31![United Airlines logo]()
$378
This United Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:00 am -
2 stops8h 08m
Tue 10/65:20 am -
1 stop4h 25m
Deal found 8/2![United Airlines logo]()
$378
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2110:40 am -
2 stops8h 20m
Fri 8/283:15 pm -
1 stop5h 09m
Deal found 7/31![United Airlines logo]()
$400
Last-minute flights from Knoxville to ColumbusDiscover last-minute flight deals from Knoxville to Columbus. Data last updated August 5, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Columbus. Data last updated August 5, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/179:08 pm -
1 stop12h 35m
Tue 8/186:10 pm -
2 stops20h 49m
Deal found 7/31![Multiple Airlines logo]()
$286
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:30 am -
1 stop6h 22m
Fri 8/286:00 am -
1 stop3h 36m
Deal found 7/31![Delta logo]()
$325
This American Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:34 am -
1 stop6h 18m
Sat 8/298:15 am -
1 stop4h 31m
Deal found 8/4![American Airlines logo]()
$314
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:10 am -
2 stops9h 50m
Sat 8/293:20 pm -
1 stop4h 00m
Deal found 8/4![Southwest logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/135:44 pm -
2 stops25h 11m
Sun 9/209:16 pm -
1 stop23h 23m
Deal found 7/31![Multiple Airlines logo]()
$298
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:00 am -
1 stop4h 08m
Sun 9/206:38 am -
1 stop5h 52m
Deal found 7/31![American Airlines logo]()
$347
This United Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/229:45 am -
1 stop4h 33m
Thu 9/245:20 am -
1 stop4h 26m
Deal found 8/2![United Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:25 pm -
1 stop4h 34m
Sun 9/276:02 am -
1 stop4h 35m
Deal found 8/5![United Airlines logo]()
$336
One-way flights from Knoxville to ColumbusSearch for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated August 5, 2026.
Search for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated August 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/265:44 pm -
2 stops21h 55m
Deal found 8/2![Multiple Airlines logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/308:00 am -
1 stop11h 44m
Deal found 7/31![Multiple Airlines logo]()
$132
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:05 am -
1 stop4h 20m
Deal found 8/4![Southwest logo]()
$152
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:00 am -
1 stop6h 06m
Deal found 8/3![United Airlines logo]()
$224
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:05 am -
2 stops9h 50m
Deal found 8/3![Southwest logo]()
$229
Find flight deals from Knoxville to Columbus
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Columbus (C01). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 5, 2026.
Round-trip from | $286 (Kiwi.com) |
|---|---|
One-way from | $129 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Columbus that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 5, 2026.
Use the filters below to find and compare flights from Knoxville to Columbus that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Tue 9/22
9:45 am-2:18 pm
1 stop4h 33m
Columbus
Thu 9/24
5:20 am-9:46 am
1 stop4h 26m
$308
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 10/2
5:40 am-12:02 pm
1 stop6h 22m
Columbus
Tue 10/6
7:00 am-10:54 am
1 stop3h 54m
$314
Quickest round-trip
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 10/2
5:45 am-9:44 am
1 stop3h 59m
Columbus
Tue 10/6
5:20 am-9:45 am
1 stop4h 25m
$314
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 8/21
7:30 am-1:52 pm
1 stop6h 22m
Columbus
Fri 8/28
6:00 am-9:36 am
1 stop3h 36m
$325
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Sun 9/13
7:00 am-11:08 am
1 stop4h 08m
Columbus
Sun 9/20
6:38 am-12:30 pm
1 stop5h 52m
$347
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Thu 11/12
8:10 am-4:45 pm
2 stops8h 35m
Columbus
Sun 11/15
6:00 am-4:50 pm
2 stops10h 50m
$367
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Sat 1/30
7:00 am-2:05 pm
2 stops7h 05m
Columbus
Wed 2/3
7:00 am-1:18 pm
1 stop6h 18m
$378
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Mon 10/5
6:00 am-2:08 pm
2 stops8h 08m
Columbus
Tue 10/6
5:20 am-9:45 am
1 stop4h 25m
$378
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Tue 9/22
8:05 am-12:25 pm
1 stop4h 20m
Columbus
Thu 9/24
8:05 am-7:10 pm
2 stops11h 05m
$386
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 8/21
10:40 am-7:00 pm
2 stops8h 20m
Columbus
Fri 8/28
3:15 pm-8:24 pm
1 stop5h 09m
$400
Showing 1-10 of 16 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Columbus
Have a flexible travel schedule? Discover the best time to fly to Columbus from Knoxville with our price prediction graph.
TYS-C01
TYS-CMH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Columbus
TYS-C01
TYS-CMH
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Columbus
Get insights into the airlines that provide service to Columbus. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Columbus. Reviews last updated August 5, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Columbus. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Crew
8.5
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.8
Crew
8.5
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.8
Crew
8.5
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Columbus. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Knoxville and Columbus flights
Browse other Knoxville and Columbus flight options. Last updated on August 5, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on August 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Columbus
Discover the top 2 airlines that operate flights from Knoxville to Columbus. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$367 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$238 | Average$336 | FlexibilityNo cancel fee | On-timeN/A |