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$146+ Cheap flights from Knoxville (TYS) to Columbus

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/27. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CMH
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Find flight deals from Knoxville to Columbus

Cheapest flights from Knoxville to Columbus
Explore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:06 amTYS - CMH
1 stop5h 38mAmerican Airlines
Thu 11/208:17 pmCMH - TYS
1 stop3h 34mAmerican Airlines
Deal found 10/16$239
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/166:00 amTYS - CMH
1 stop5h 50mAmerican Airlines
Wed 12/1711:22 amCMH - TYS
1 stop4h 51mAmerican Airlines
Deal found 10/16$251
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/248:10 pmTYS - CMH
1 stop3h 49mDelta
Sun 10/267:59 pmCMH - TYS
1 stop3h 47mDelta
Deal found 10/16$259
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/208:10 pmTYS - CMH
1 stop3h 49mDelta
Mon 10/277:59 pmCMH - TYS
1 stop3h 47mDelta
Deal found 10/15$269
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/245:59 pmTYS - CMH
2 stops18h 10mMultiple Airlines
Sun 10/264:10 pmCMH - TYS
1 stop20h 38mMultiple Airlines
Deal found 10/16$275
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/175:44 amTYS - CMH
1 stop5h 29mDelta
Sat 10/188:05 amCMH - TYS
1 stop5h 37mDelta
Deal found 10/16$279
This Mytrip deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:30 amTYS - CMH
2 stops16h 40mMultiple Airlines
Thu 11/208:30 amCMH - TYS
1 stop12h 23mMultiple Airlines
Deal found 10/16$296
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/207:29 pmTYS - CMH
1 stop5h 06mAmerican Airlines
Sat 1/177:43 amCMH - TYS
1 stop3h 59mAmerican Airlines
Deal found 10/15$298
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:37 pmTYS - CMH
1 stop3h 22mAmerican Airlines
Thu 10/237:21 amCMH - TYS
1 stop6h 27mAmerican Airlines
Deal found 10/16$319
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:11 pmTYS - CMH
1 stop5h 48mAmerican Airlines
Sun 10/197:00 amCMH - TYS
1 stop5h 31mAmerican Airlines
Deal found 10/15$359

Cheap flight deals from Knoxville to Columbus

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Columbus (C01). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 16, 2025.

Round-trip from

$239
(American Airlines)

One-way from

$146
(Kiwi.com)

Popular in

December

Cheapest in

January

Average price

$318
From Knoxville McGhee Tyson to Columbus
Search Deals
One-way flight from Knoxville McGhee Tyson to Columbus
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Highest demand for flights based on searches. 3% potential increase in price ($11 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Columbus that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Knoxville to Columbus that are best for you.

Fly from

Knoxville

Fly to

Columbus

Route

Depart

Return

Price

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Thu 11/13

6:06 am-11:44 am

1 stop5h 38m

Columbus

Thu 11/20

8:17 pm-11:51 pm

1 stop3h 34m

$239

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Tue 12/16

6:00 am-11:50 am

1 stop5h 50m

Columbus

Wed 12/17

11:22 am-4:13 pm

1 stop4h 51m

$251

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Thu 11/13

6:30 am-11:10 pm

2 stops16h 40m

Columbus

Thu 11/20

8:30 am-8:53 pm

1 stop12h 23m

$296

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Sat 12/20

7:29 pm-12:35 am

1 stop5h 06m

Columbus

Sat 1/17

7:43 am-11:42 am

1 stop3h 59m

$298

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Fri 3/6

10:05 am-2:31 pm

1 stop4h 26m

Columbus

Tue 3/10

6:05 am-11:07 am

1 stop5h 02m

$408

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Tue 12/16

2:30 pm-7:03 pm

1 stop4h 33m

Columbus

Wed 12/17

9:00 am-7:29 pm

2 stops10h 29m

$449

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Mon 10/27

11:00 am-2:29 pm

3 stops51h 29m

$146

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Wed 10/22

4:26 pm-11:58 am

1 stop19h 32m

$194

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Thu 10/30

8:26 am-3:22 pm

1 stop6h 56m

$199

KnoxvilleColumbus

TYS - CMH

TYSCMH

Knoxville McGhee Tyson

Tue 10/21

11:23 am-2:29 pm

2 stops27h 06m

$251

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/14

Showing 1-10 of 12 results
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Best time to book a flight from Knoxville to Columbus

Have a flexible travel schedule? Discover the best time to fly to Columbus from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Columbus

What is the cheapest month to book a flight from Knoxville to Columbus?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Columbus (average of $171). Flying from Knoxville to Columbus in December is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CMH?

Find hourly flight availability from Knoxville to Columbus. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

It’s typically best to fly out from Knoxville to Columbus at noon. Doing so could potentially save you 46% on the flight price compared to flying in the afternoon, which is usually more expensive.

Reviews of airlines servicing Columbus

Get insights into the airlines that provide service to Columbus. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Columbus. Reviews last updated October 16, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Knoxville to Columbus. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,984 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,984 reviews
Delta
8.0
Very good
7,984 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,982 reviews
Delta
8.0
Very good
7,984 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,043 reviews
Delta
8.0
Very good
7,984 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Columbus. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Columbus?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Columbus. You should not have trouble finding flights to Columbus from McGhee Tyson; the airport handles an average of 0 outbound flights to Columbus per day. You should also have plenty of airline options to choose from since 3 airlines have flights from the Knoxville airport to Columbus. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Columbus?

    For as low as $239, American Airlines can have you in Columbus from Knoxville in 5h 38m. Airlines will cover a distance of 296 mi.

  • What are the cheapest airlines flying from Knoxville to Columbus round-trip?

    Delta, at $218, was found to be the cheapest airline from Knoxville to Columbus.Alternate airlines to your destination round-trip include American Airlines and United Airlines. Delta is priced at 35% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Knoxville to Columbus that include hotel bookings?

    Yes. In addition to deals on Knoxville to Columbus flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Columbus?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Columbus.

  • Can I find deals for business class flights from Knoxville to Columbus?

    Yes. Cheapflights offers flight deals from Knoxville to Columbus by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Columbus?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Columbus (average of $171). Flying from Knoxville to Columbus in December is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Columbus

Discover the top 3 airlines that operate flights from Knoxville to Columbus. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$218Average$318FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$223Average$293FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$298Average$539FlexibilityNo cancel feeOn-time69%

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