$131+ Cheap flights from Knoxville (TYS) to Columbus
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CMH
Sep 25 — Oct 21
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Knoxville to ColumbusExplore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 26, 2026.
Explore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 26, 2026.
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:15 am -
1 stop4h 13m
Thu 9/101:07 pm -
1 stop5h 40m
Deal found 8/21![Delta logo]()
$273
This Southwest deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/111:00 pm -
2 stops9h 15m
Sat 9/123:20 pm -
1 stop4h 05m
Deal found 8/24![Southwest logo]()
$278
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:45 am -
1 stop3h 59m
Tue 10/65:20 am -
1 stop4h 25m
Deal found 8/25![United Airlines logo]()
$288
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:30 am -
1 stop5h 14m
Sat 1/25:10 am -
1 stop5h 00m
Deal found 8/25![United Airlines logo]()
$310
This Southwest deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:20 am -
1 stop10h 10m
Mon 10/53:50 pm -
2 stops6h 50m
Deal found 8/24![Southwest logo]()
$319
This Southwest deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:25 pm -
1 stop3h 20m
Mon 10/1912:30 pm -
2 stops10h 10m
Deal found 8/25![Southwest logo]()
$325
This Delta deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:40 am -
1 stop4h 21m
Wed 10/711:15 am -
1 stop4h 11m
Deal found 8/23![Delta logo]()
$330
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:02 pm -
1 stop5h 57m
Mon 9/144:20 pm -
1 stop6h 29m
Deal found 8/24![United Airlines logo]()
$343
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:00 am -
2 stops8h 18m
Sat 9/124:11 pm -
2 stops7h 48m
Deal found 8/24![United Airlines logo]()
$353
Best flights from Knoxville to ColumbusDiscover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 26, 2026.
Discover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 26, 2026.
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/112:23 pm -
1 stop5h 47m
Mon 10/53:10 pm -
1 stop5h 05m
Deal found 8/24![Delta logo]()
$273
This Southwest deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/111:00 pm -
2 stops9h 15m
Sat 9/123:20 pm -
1 stop4h 05m
Deal found 8/24![Southwest logo]()
$278
This United Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:45 am -
1 stop3h 59m
Tue 10/65:20 am -
1 stop4h 25m
Deal found 8/22![United Airlines logo]()
$288
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/295:57 pm -
1 stop4h 49m
Mon 1/47:55 pm -
1 stop3h 51m
Deal found 8/21![Delta logo]()
$310
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:30 am -
1 stop6h 46m
Sun 1/32:18 pm -
1 stop6h 33m
Deal found 8/25![United Airlines logo]()
$310
This Southwest deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:15 am -
2 stops9h 40m
Mon 10/53:50 pm -
2 stops6h 50m
Deal found 8/24![Southwest logo]()
$340
This United Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:02 pm -
1 stop5h 57m
Mon 9/144:20 pm -
1 stop6h 29m
Deal found 8/22![United Airlines logo]()
$343
This United Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:15 am -
1 stop8h 47m
Thu 9/104:19 pm -
1 stop6h 30m
Deal found 8/22![United Airlines logo]()
$343
Last-minute flights from Knoxville to ColumbusDiscover last-minute flight deals from Knoxville to Columbus. Data last updated August 26, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Columbus. Data last updated August 26, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:45 am -
1 stop4h 01m
Fri 9/1110:32 am -
1 stop6h 26m
Deal found 8/21![United Airlines logo]()
$360
This Southwest deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:45 pm -
1 stop5h 10m
Fri 9/117:20 am -
2 stops11h 20m
Deal found 8/21![Southwest logo]()
$428
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:15 am -
1 stop4h 13m
Thu 9/101:07 pm -
1 stop5h 40m
Deal found 8/21![Delta logo]()
$273
This United Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:00 am -
2 stops7h 18m
Thu 9/106:05 am -
2 stops8h 32m
Deal found 8/22![United Airlines logo]()
$388
This Southwest deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:30 pm -
1 stop3h 45m
Sun 9/1312:45 pm -
2 stops8h 05m
Deal found 8/25![Southwest logo]()
$415
This Southwest deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/111:00 pm -
2 stops9h 15m
Sat 9/123:20 pm -
1 stop4h 05m
Deal found 8/24![Southwest logo]()
$278
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:02 pm -
1 stop5h 57m
Mon 9/144:20 pm -
1 stop6h 29m
Deal found 8/24![United Airlines logo]()
$343
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:00 am -
2 stops8h 18m
Sat 9/124:11 pm -
2 stops7h 48m
Deal found 8/24![United Airlines logo]()
$353
This Southwest deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/111:00 pm -
2 stops9h 15m
Sun 9/132:05 pm -
1 stop6h 45m
Deal found 8/24![Southwest logo]()
$371
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:25 pm -
1 stop4h 34m
Thu 10/15:20 am -
1 stop4h 25m
Deal found 8/25![United Airlines logo]()
$358
One-way flights from Knoxville to ColumbusSearch for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated August 26, 2026.
Search for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated August 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:15 am -
2 stops12h 33m
Deal found 8/25![Multiple Airlines logo]()
$131
This United Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:00 am -
1 stop4h 35m
Deal found 8/21![United Airlines logo]()
$137
This Southwest deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:40 am -
2 stops10h 40m
Deal found 8/23![Southwest logo]()
$148
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:06 pm -
1 stop5h 47m
Deal found 8/22![American Airlines logo]()
$152
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:54 pm -
2 stops26h 33m
Deal found 8/25![Multiple Airlines logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/181:54 pm -
2 stops28h 33m
Deal found 8/22![Multiple Airlines logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:18 pm -
3 stops25h 17m
Deal found 8/23![Multiple Airlines logo]()
$224
This Southwest deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/68:00 am -
2 stops9h 25m
Deal found 8/21![Southwest logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:49 pm -
2 stops22h 45m
Deal found 8/25![Multiple Airlines logo]()
$255
Find flight deals from Knoxville to Columbus
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Columbus (C01). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 26, 2026.
Round-trip from | $273 (Delta) |
|---|---|
One-way from | $131 (Kiwi.com) |
Popular in | June |
Cheapest in | October |
Average price | $292 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Columbus that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 26, 2026.
Use the filters below to find and compare flights from Knoxville to Columbus that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Thu 10/1
12:23 pm-6:10 pm
1 stop5h 47m
Columbus
Mon 10/5
3:10 pm-8:15 pm
1 stop5h 05m
$273
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 9/11
1:00 pm-10:15 pm
2 stops9h 15m
Columbus
Sat 9/12
3:20 pm-7:25 pm
1 stop4h 05m
$278
Quickest round-trip
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 10/2
5:45 am-9:44 am
1 stop3h 59m
Columbus
Tue 10/6
5:20 am-9:45 am
1 stop4h 25m
$288
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Tue 12/29
5:57 pm-10:46 pm
1 stop4h 49m
Columbus
Mon 1/4
7:55 pm-11:46 pm
1 stop3h 51m
$310
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Wed 12/30
6:30 am-1:16 pm
1 stop6h 46m
Columbus
Sun 1/3
2:18 pm-8:51 pm
1 stop6h 33m
$310
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Thu 10/1
7:15 am-4:55 pm
2 stops9h 40m
Columbus
Mon 10/5
3:50 pm-10:40 pm
2 stops6h 50m
$340
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 9/11
6:02 pm-11:59 pm
1 stop5h 57m
Columbus
Mon 9/14
4:20 pm-10:49 pm
1 stop6h 29m
$343
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Sun 9/6
7:15 am-4:02 pm
1 stop8h 47m
Columbus
Thu 9/10
4:19 pm-10:49 pm
1 stop6h 30m
$343
Cheapest one-way
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Thu 10/15
6:00 am-1:14 pm
1 stop7h 14m
$137
Quickest one-way
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Sun 9/6
7:00 am-11:35 am
1 stop4h 35m
$137
Showing 1-10 of 19 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Columbus
Have a flexible travel schedule? Discover the best time to fly to Columbus from Knoxville with our price prediction graph.
TYS-C01
TYS-CMH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Columbus
TYS-C01
TYS-CMH
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Columbus
Get insights into the airlines that provide service to Columbus. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Columbus. Reviews last updated August 26, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Columbus. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Entertainment
7.8
Food
7.2
Overall
7.8
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Crew
8.5
Entertainment
7.8
Food
7.2
Overall
7.8
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Crew
8.5
Entertainment
7.8
Food
7.2
Overall
7.8
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Columbus. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Knoxville and Columbus flights
Browse other Knoxville and Columbus flight options. Last updated on August 26, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on August 26, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Columbus
Discover the top 2 airlines that operate flights from Knoxville to Columbus. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$394 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$238 | Average$350 | FlexibilityNo cancel fee | On-timeN/A |