$112+ Cheap flights from Knoxville (TYS) to Columbus
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/22. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CMH
May 21 — May 281
Round-trip
1 adult, Economy
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Cheapest flights from Knoxville to ColumbusExplore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 21, 2026.
Explore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/235:02 pm
TYS
- CMH
1 stop6h 21m
Multiple Airlines
Sun 6/286:00 pm
CMH
- TYS
2 stops27h 50m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$250
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:33 pm
TYS
- CMH
1 stop4h 57m
Delta
Wed 5/136:05 am
CMH
- TYS
1 stop3h 29m
Delta
Deal found 4/20![Delta logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/64:25 pm
TYS
- CMH
2 stops24h 45m
Multiple Airlines
Sun 5/106:00 am
CMH
- TYS
1 stop14h 50m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/181:15 pm
TYS
- CMH
2 stops27h 55m
Multiple Airlines
Mon 5/251:37 pm
CMH
- TYS
1 stop10h 00m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$302
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/41:15 pm
TYS
- CMH
1 stop23h 27m
Multiple Airlines
Fri 5/88:48 pm
CMH
- TYS
2 stops14h 18m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/64:25 pm
TYS
- CMH
2 stops20h 17m
Multiple Airlines
Thu 5/77:20 pm
CMH
- TYS
1 stop22h 10m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$336
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:59 pm
TYS
- CMH
1 stop3h 53m
American Airlines
Mon 5/256:00 am
CMH
- TYS
1 stop7h 10m
American Airlines
Deal found 4/16![American Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/57:45 pm
TYS
- CMH
1 stop3h 45m
Southwest
Tue 6/95:40 am
CMH
- TYS
2 stops6h 25m
Southwest
Deal found 4/18![Southwest logo]()
$342
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:00 am
TYS
- CMH
1 stop6h 19m
American Airlines
Mon 7/134:38 pm
CMH
- TYS
1 stop4h 54m
American Airlines
Deal found 4/19![American Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:35 am
TYS
- CMH
2 stops11h 35m
Southwest
Mon 5/255:50 am
CMH
- TYS
1 stop8h 20m
Southwest
Deal found 4/17![Southwest logo]()
$348
Best flights from Knoxville to ColumbusDiscover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 21, 2026.
Discover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 21, 2026.
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:33 pm
TYS
- CMH
1 stop4h 57m
Delta
Wed 5/136:05 am
CMH
- TYS
1 stop3h 29m
Delta
Deal found 4/20![Delta logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/181:15 pm
TYS
- CMH
2 stops27h 55m
Multiple Airlines
Mon 5/251:37 pm
CMH
- TYS
1 stop10h 00m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$302
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/57:45 pm
TYS
- CMH
1 stop3h 45m
Southwest
Tue 6/96:00 am
CMH
- TYS
1 stop8h 05m
Southwest
Deal found 4/18![Southwest logo]()
$337
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:59 pm
TYS
- CMH
1 stop3h 53m
American Airlines
Mon 5/256:00 am
CMH
- TYS
1 stop7h 10m
American Airlines
Deal found 4/16![American Airlines logo]()
$337
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/41:15 pm
TYS
- CMH
1 stop23h 27m
Multiple Airlines
Fri 5/88:48 pm
CMH
- TYS
2 stops14h 18m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$334
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:00 am
TYS
- CMH
1 stop6h 19m
American Airlines
Mon 7/134:38 pm
CMH
- TYS
1 stop4h 54m
American Airlines
Deal found 4/19![American Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:35 am
TYS
- CMH
2 stops11h 35m
Southwest
Mon 5/255:50 am
CMH
- TYS
1 stop8h 20m
Southwest
Deal found 4/17![Southwest logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:24 pm
TYS
- CMH
1 stop15h 52m
Multiple Airlines
Mon 5/251:37 pm
CMH
- TYS
1 stop10h 00m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$348
Last-minute flights from Knoxville to ColumbusDiscover last-minute flight deals from Knoxville to Columbus. Data last updated April 21, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Columbus. Data last updated April 21, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/41:15 pm
TYS
- CMH
1 stop23h 27m
Multiple Airlines
Fri 5/88:48 pm
CMH
- TYS
2 stops14h 18m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/64:25 pm
TYS
- CMH
2 stops24h 45m
Multiple Airlines
Sun 5/106:00 am
CMH
- TYS
1 stop14h 50m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/64:25 pm
TYS
- CMH
2 stops20h 17m
Multiple Airlines
Thu 5/77:20 pm
CMH
- TYS
1 stop22h 10m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$336
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:33 pm
TYS
- CMH
1 stop4h 57m
Delta
Wed 5/136:05 am
CMH
- TYS
1 stop3h 29m
Delta
Deal found 4/20![Delta logo]()
$270
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:45 pm
TYS
- CMH
1 stop3h 20m
Southwest
Wed 5/131:15 pm
CMH
- TYS
2 stops6h 25m
Southwest
Deal found 4/20![Southwest logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/181:15 pm
TYS
- CMH
2 stops27h 55m
Multiple Airlines
Mon 5/251:37 pm
CMH
- TYS
1 stop10h 00m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$302
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:59 pm
TYS
- CMH
1 stop3h 53m
American Airlines
Mon 5/256:00 am
CMH
- TYS
1 stop7h 10m
American Airlines
Deal found 4/16![American Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:35 am
TYS
- CMH
2 stops11h 35m
Southwest
Mon 5/255:50 am
CMH
- TYS
1 stop8h 20m
Southwest
Deal found 4/17![Southwest logo]()
$348
One-way flights from Knoxville to ColumbusSearch for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated April 21, 2026.
Search for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated April 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/2212:40 pm
TYS
- CMH
2 stops28h 25m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$112
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:00 pm
TYS
- CMH
1 stop19h 42m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$130
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:33 pm
TYS
- CMH
1 stop4h 52m
Delta
Deal found 4/17![Delta logo]()
$140
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:05 am
TYS
- CMH
2 stops11h 40m
Southwest
Deal found 4/17![Southwest logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:24 pm
TYS
- CMH
2 stops21h 46m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$152
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/215:40 am
TYS
- CMH
1 stop3h 19m
Delta
Deal found 4/16![Delta logo]()
$176
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/217:00 pm
TYS
- CMH
1 stop3h 50m
Southwest
Deal found 4/16![Southwest logo]()
$179
Find flight deals from Knoxville to Columbus
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Columbus (C01). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 21, 2026.
Round-trip from | $250 (Kiwi.com) |
|---|---|
One-way from | $130 (Kiwi.com) |
Popular in | April |
Cheapest in | October |
Average price | $494 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Columbus that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 21, 2026.
Use the filters below to find and compare flights from Knoxville to Columbus that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Mon 5/11
7:33 pm-12:30 am
1 stop4h 57m
Columbus
Wed 5/13
6:05 am-9:34 am
1 stop3h 29m
$270
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Mon 5/18
1:15 pm-5:10 pm
2 stops27h 55m
Columbus
Mon 5/25
1:37 pm-11:37 pm
1 stop10h 00m
$302
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Mon 5/4
1:15 pm-12:42 pm
1 stop23h 27m
Columbus
Fri 5/8
8:48 pm-11:06 am
2 stops14h 18m
$334
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Fri 6/5
7:45 pm-11:30 pm
1 stop3h 45m
Columbus
Tue 6/9
6:00 am-2:05 pm
1 stop8h 05m
$337
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Fri 5/22
7:59 pm-11:52 pm
1 stop3h 53m
Columbus
Mon 5/25
6:00 am-1:10 pm
1 stop7h 10m
$337
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Fri 7/10
6:00 am-12:19 pm
1 stop6h 19m
Columbus
Mon 7/13
4:38 pm-9:32 pm
1 stop4h 54m
$347
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Fri 5/22
6:35 am-6:10 pm
2 stops11h 35m
Columbus
Mon 5/25
5:50 am-2:10 pm
1 stop8h 20m
$348
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Fri 5/22
7:24 pm-11:16 am
1 stop15h 52m
Columbus
Mon 5/25
1:37 pm-11:37 pm
1 stop10h 00m
$348
Cheapest one-way
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Mon 6/22
12:40 pm-5:05 pm
2 stops28h 25m
$112
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Tue 5/26
5:00 pm-12:42 pm
1 stop19h 42m
$130
Showing 1-10 of 14 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Columbus
Have a flexible travel schedule? Discover the best time to fly to Columbus from Knoxville with our price prediction graph.
TYS-C01
TYS-CMH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Columbus
TYS-C01
TYS-CMH
How much does it cost to fly round-trip from Knoxville to Columbus?
Reviews of airlines servicing Columbus
Get insights into the airlines that provide service to Columbus. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Columbus. Reviews last updated April 21, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Knoxville to Columbus. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Food
7.2
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Food
7.2
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Food
7.2
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Food
7.2
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Columbus. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to Columbus
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Complete your trip
Complete your trip to Columbus by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Columbus by cabin class
Find flights from Knoxville to Columbus, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Columbus flights
Browse other Knoxville and Columbus flight options. Last updated on April 21, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on April 21, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Knoxville to Columbus
Discover the top 3 airlines that operate flights from Knoxville to Columbus. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$218 | Average$318 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$228 | Average$258 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$294 | Average$361 | FlexibilityNo cancel fee | On-time69% |