$195+ Cheap flights from Knoxville (TYS) to Columbus
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/21. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CMH
Sep 9 — Sep 161
Round-trip
1 adult, Economy
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Cheapest flights from Knoxville to ColumbusExplore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 10, 2026.
Explore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:30 am -
2 stops34h 25m
Wed 9/309:16 pm -
1 stop22h 38m
Deal found 8/8![Multiple Airlines logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/49:33 pm -
2 stops43h 52m
Fri 9/117:35 pm -
1 stop22h 30m
Deal found 8/7![Multiple Airlines logo]()
$272
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:55 pm -
2 stops24h 00m
Fri 10/27:35 pm -
1 stop22h 18m
Deal found 8/5![Multiple Airlines logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/135:44 pm -
2 stops25h 11m
Sun 9/209:16 pm -
1 stop23h 23m
Deal found 8/8![Multiple Airlines logo]()
$294
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/47:25 pm -
1 stop3h 30m
Fri 9/113:13 pm -
1 stop4h 30m
Deal found 8/7![American Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:51 pm -
1 stop18h 52m
Mon 8/3110:28 am -
1 stop8h 35m
Deal found 8/9![Multiple Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:00 am -
1 stop5h 55m
Tue 10/65:20 am -
1 stop4h 25m
Deal found 8/6![United Airlines logo]()
$314
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:25 pm -
1 stop4h 34m
Sun 9/276:02 am -
1 stop4h 35m
Deal found 8/5![United Airlines logo]()
$336
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/28:55 am -
1 stop5h 07m
Tue 10/66:00 am -
1 stop4h 54m
Deal found 8/6![Delta logo]()
$345
This Delta deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:33 am -
1 stop5h 56m
Mon 10/57:19 pm -
1 stop4h 36m
Deal found 8/8![Delta logo]()
$347
This Southwest deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:05 am -
2 stops6h 50m
Wed 9/309:10 am -
2 stops9h 50m
Deal found 8/8![Southwest logo]()
$357
Best flights from Knoxville to ColumbusDiscover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 10, 2026.
Discover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/49:33 pm -
2 stops43h 52m
Fri 9/117:35 pm -
1 stop22h 30m
Deal found 8/7![Multiple Airlines logo]()
$272
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:45 am -
1 stop3h 59m
Tue 10/65:20 am -
1 stop4h 25m
Deal found 8/5![United Airlines logo]()
$314
This Southwest deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:25 am -
1 stop4h 50m
Wed 9/99:10 am -
2 stops10h 45m
Deal found 8/8![Southwest logo]()
$372
This Delta deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:33 am -
1 stop3h 49m
Sun 10/42:09 pm -
1 stop3h 29m
Deal found 8/8![Delta logo]()
$413
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:25 pm -
1 stop4h 34m
Sun 9/276:02 am -
1 stop4h 35m
Deal found 8/5![United Airlines logo]()
$336
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:00 am -
1 stop4h 40m
Mon 9/712:30 pm -
1 stop4h 28m
Deal found 8/6![United Airlines logo]()
$373
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:10 am -
2 stops9h 50m
Mon 8/319:50 am -
2 stops8h 45m
Deal found 8/9![Southwest logo]()
$427
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/28:20 am -
2 stops14h 25m
Tue 10/66:00 am -
2 stops10h 40m
Deal found 8/7![Southwest logo]()
$428
Last-minute flights from Knoxville to ColumbusDiscover last-minute flight deals from Knoxville to Columbus. Data last updated August 10, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Columbus. Data last updated August 10, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:51 pm -
1 stop18h 52m
Mon 8/3110:28 am -
1 stop8h 35m
Deal found 8/9![Multiple Airlines logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/49:33 pm -
2 stops43h 52m
Fri 9/117:35 pm -
1 stop22h 30m
Deal found 8/7![Multiple Airlines logo]()
$272
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/47:25 pm -
1 stop3h 30m
Fri 9/113:13 pm -
1 stop4h 30m
Deal found 8/7![American Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/135:44 pm -
2 stops25h 11m
Sun 9/209:16 pm -
1 stop23h 23m
Deal found 8/8![Multiple Airlines logo]()
$294
This United Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/136:00 am -
1 stop5h 40m
Sun 9/206:00 am -
1 stop4h 37m
Deal found 8/8![United Airlines logo]()
$347
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:30 am -
2 stops34h 25m
Wed 9/309:16 pm -
1 stop22h 38m
Deal found 8/8![Multiple Airlines logo]()
$243
This Southwest deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:05 am -
2 stops6h 50m
Wed 9/309:10 am -
2 stops9h 50m
Deal found 8/8![Southwest logo]()
$357
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:25 pm -
1 stop4h 34m
Sun 9/276:02 am -
1 stop4h 35m
Deal found 8/5![United Airlines logo]()
$336
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/258:20 am -
1 stop12h 11m
Sun 9/277:50 pm -
2 stops20h 53m
Deal found 8/5![Multiple Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:55 pm -
2 stops24h 00m
Fri 10/27:35 pm -
1 stop22h 18m
Deal found 8/5![Multiple Airlines logo]()
$282
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/264:48 pm -
1 stop7h 11m
Fri 10/22:50 pm -
1 stop6h 16m
Deal found 8/5![American Airlines logo]()
$314
One-way flights from Knoxville to ColumbusSearch for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated August 10, 2026.
Search for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated August 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:51 pm -
2 stops41h 37m
Deal found 8/8![Multiple Airlines logo]()
$195
This KAYAK deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/138:35 am -
1 stop5h 17m
Deal found 8/5![Delta logo]()
$286
This KAYAK deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/131:56 pm -
2 stops8h 27m
Deal found 8/5![American Airlines logo]()
$301
Find flight deals from Knoxville to Columbus
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Columbus (C01). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 10, 2026.
Round-trip from | $243 (Kiwi.com) |
|---|---|
One-way from | $195 (Kiwi.com) |
Popular in | June |
Cheapest in | October |
Average price | $292 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Columbus that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 10, 2026.
Use the filters below to find and compare flights from Knoxville to Columbus that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 9/4
9:33 pm-5:25 pm
2 stops43h 52m
Columbus
Fri 9/11
7:35 pm-6:05 pm
1 stop22h 30m
$272
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 10/2
5:45 am-9:44 am
1 stop3h 59m
Columbus
Tue 10/6
5:20 am-9:45 am
1 stop4h 25m
$314
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 9/25
7:25 pm-11:59 pm
1 stop4h 34m
Columbus
Sun 9/27
6:02 am-10:37 am
1 stop4h 35m
$336
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Thu 9/3
8:25 am-1:15 pm
1 stop4h 50m
Columbus
Wed 9/9
9:10 am-7:55 pm
2 stops10h 45m
$372
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Thu 9/3
7:00 am-11:40 am
1 stop4h 40m
Columbus
Mon 9/7
12:30 pm-4:58 pm
1 stop4h 28m
$373
Quickest round-trip
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Sat 10/3
7:33 am-11:22 am
1 stop3h 49m
Columbus
Sun 10/4
2:09 pm-5:38 pm
1 stop3h 29m
$413
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 8/28
7:10 am-5:00 pm
2 stops9h 50m
Columbus
Mon 8/31
9:50 am-6:35 pm
2 stops8h 45m
$427
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 10/2
8:20 am-10:45 pm
2 stops14h 25m
Columbus
Tue 10/6
6:00 am-4:40 pm
2 stops10h 40m
$428
Cheapest one-way
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Fri 8/21
2:51 pm-8:28 am
2 stops41h 37m
$195
Quickest one-way
KnoxvilleColumbus
TYS Knoxville McGhee Tyson - CMH Columbus
TYSCMH
Knoxville McGhee Tyson
Thu 8/13
8:35 am-1:52 pm
1 stop5h 17m
$286
Showing 1-10 of 11 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Columbus
Have a flexible travel schedule? Discover the best time to fly to Columbus from Knoxville with our price prediction graph.
TYS-C01
TYS-CMH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Columbus
TYS-C01
TYS-CMH
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Columbus
Get insights into the airlines that provide service to Columbus. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Columbus. Reviews last updated August 10, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Columbus. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Overall
7.8
Entertainment
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Overall
7.8
Entertainment
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Overall
7.8
Entertainment
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Columbus. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Knoxville and Columbus flights
Browse other Knoxville and Columbus flight options. Last updated on August 10, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on August 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Columbus
Discover the top 2 airlines that operate flights from Knoxville to Columbus. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$326 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$238 | Average$350 | FlexibilityNo cancel fee | On-timeN/A |