$125+ Cheap flights from Knoxville (TYS) to Columbus
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/3. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CMH
Jul 18 — Jul 251
Round-trip
1 adult, Economy
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Cheapest flights from Knoxville to ColumbusExplore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 18, 2026.
Explore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 18, 2026.
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:15 am
TYS
- CMH
1 stop6h 12m
Delta
Wed 7/158:11 am
CMH
- TYS
1 stop5h 05m
Delta
Deal found 6/14![Delta logo]()
$265
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:10 am
TYS
- CMH
2 stops7h 50m
Southwest
Wed 7/154:20 pm
CMH
- TYS
1 stop5h 00m
Southwest
Deal found 6/14![Southwest logo]()
$270
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1211:40 am
TYS
- CMH
1 stop7h 04m
American Airlines
Thu 8/136:00 am
CMH
- TYS
1 stop3h 43m
American Airlines
Deal found 6/16![American Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:10 am
TYS
- CMH
2 stops10h 20m
Southwest
Tue 7/2112:55 pm
CMH
- TYS
2 stops8h 25m
Southwest
Deal found 6/16![Southwest logo]()
$281
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:00 am
TYS
- CMH
2 stops7h 55m
Southwest
Thu 8/137:30 am
CMH
- TYS
1 stop5h 55m
Southwest
Deal found 6/16![Southwest logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1412:50 pm
TYS
- CMH
1 stop6h 15m
Multiple Airlines
Sun 8/165:44 pm
CMH
- TYS
2 stops14h 52m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:52 pm
TYS
- CMH
1 stop4h 41m
American Airlines
Thu 8/134:23 pm
CMH
- TYS
1 stop6h 35m
American Airlines
Deal found 6/16![American Airlines logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:29 pm
TYS
- CMH
1 stop15h 39m
Multiple Airlines
Thu 8/135:44 pm
CMH
- TYS
2 stops14h 52m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$295
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:00 am
TYS
- CMH
1 stop3h 47m
American Airlines
Sat 7/42:00 pm
CMH
- TYS
1 stop3h 49m
American Airlines
Deal found 6/15![American Airlines logo]()
$299
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/158:05 pm
TYS
- CMH
1 stop3h 51m
American Airlines
Mon 7/205:26 pm
CMH
- TYS
1 stop6h 25m
American Airlines
Deal found 6/16![American Airlines logo]()
$301
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1012:40 pm
TYS
- CMH
1 stop6h 25m
Multiple Airlines
Wed 7/159:54 am
CMH
- TYS
2 stops26h 15m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$302
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3012:45 pm
TYS
- CMH
2 stops10h 05m
Southwest
Sat 7/48:55 am
CMH
- TYS
1 stop2h 55m
Southwest
Deal found 6/15![Southwest logo]()
$304
Best flights from Knoxville to ColumbusDiscover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 18, 2026.
Discover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 18, 2026.
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:10 am
TYS
- CMH
2 stops10h 20m
Southwest
Tue 7/2112:55 pm
CMH
- TYS
2 stops8h 25m
Southwest
Deal found 6/16![Southwest logo]()
$281
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:02 pm
TYS
- CMH
1 stop5h 57m
United Airlines
Wed 8/1911:05 am
CMH
- TYS
1 stop5h 53m
United Airlines
Deal found 6/14![United Airlines logo]()
$335
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/93:59 pm
TYS
- CMH
1 stop5h 03m
Delta
Sun 7/128:08 pm
CMH
- TYS
1 stop3h 44m
Delta
Deal found 6/13![Delta logo]()
$357
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3012:45 pm
TYS
- CMH
2 stops10h 05m
Southwest
Sat 7/48:55 am
CMH
- TYS
1 stop2h 55m
Southwest
Deal found 6/15![Southwest logo]()
$304
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/158:10 am
TYS
- CMH
2 stops9h 20m
Southwest
Mon 7/2011:55 am
CMH
- TYS
2 stops10h 40m
Southwest
Deal found 6/16![Southwest logo]()
$311
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/117:00 am
TYS
- CMH
1 stop5h 15m
Southwest
Tue 7/145:40 am
CMH
- TYS
2 stops6h 25m
Southwest
Deal found 6/16![Southwest logo]()
$326
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/412:30 pm
TYS
- CMH
1 stop6h 35m
Southwest
Sat 7/116:50 am
CMH
- TYS
1 stop5h 05m
Southwest
Deal found 6/14![Southwest logo]()
$338
Last-minute flights from Knoxville to ColumbusDiscover last-minute flight deals from Knoxville to Columbus. Data last updated June 18, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Columbus. Data last updated June 18, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:00 am
TYS
- CMH
1 stop3h 47m
American Airlines
Sat 7/42:00 pm
CMH
- TYS
1 stop3h 49m
American Airlines
Deal found 6/15![American Airlines logo]()
$299
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3012:45 pm
TYS
- CMH
2 stops10h 05m
Southwest
Sat 7/48:55 am
CMH
- TYS
1 stop2h 55m
Southwest
Deal found 6/15![Southwest logo]()
$304
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:15 am
TYS
- CMH
1 stop6h 12m
Delta
Wed 7/158:11 am
CMH
- TYS
1 stop5h 05m
Delta
Deal found 6/14![Delta logo]()
$265
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:10 am
TYS
- CMH
2 stops7h 50m
Southwest
Wed 7/154:20 pm
CMH
- TYS
1 stop5h 00m
Southwest
Deal found 6/14![Southwest logo]()
$270
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/85:45 am
TYS
- CMH
1 stop4h 04m
United Airlines
Sat 7/112:19 pm
CMH
- TYS
1 stop6h 25m
United Airlines
Deal found 6/14![United Airlines logo]()
$321
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:10 am
TYS
- CMH
2 stops7h 50m
Southwest
Sat 7/117:40 am
CMH
- TYS
1 stop6h 25m
Southwest
Deal found 6/14![Southwest logo]()
$326
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1012:40 pm
TYS
- CMH
1 stop6h 25m
Multiple Airlines
Wed 7/159:54 am
CMH
- TYS
2 stops26h 15m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$302
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:10 am
TYS
- CMH
2 stops10h 20m
Southwest
Tue 7/2112:55 pm
CMH
- TYS
2 stops8h 25m
Southwest
Deal found 6/16![Southwest logo]()
$281
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/158:05 pm
TYS
- CMH
1 stop3h 51m
American Airlines
Mon 7/205:26 pm
CMH
- TYS
1 stop6h 25m
American Airlines
Deal found 6/16![American Airlines logo]()
$301
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:55 pm
TYS
- CMH
1 stop3h 10m
Southwest
Mon 7/201:05 pm
CMH
- TYS
2 stops9h 30m
Southwest
Deal found 6/16![Southwest logo]()
$306
One-way flights from Knoxville to ColumbusSearch for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated June 18, 2026.
Search for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated June 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:53 pm
TYS
- CMH
2 stops28h 06m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$125
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/18:05 pm
TYS
- CMH
1 stop3h 51m
American Airlines
Deal found 6/15![American Airlines logo]()
$169
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/18:40 pm
TYS
- CMH
3 stops16h 03m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$275
Find flight deals from Knoxville to Columbus
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Columbus (C01). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 18, 2026.
Round-trip from | $265 (American Airlines) |
|---|---|
One-way from | $125 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Columbus that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 18, 2026.
Use the filters below to find and compare flights from Knoxville to Columbus that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Tue 7/14
7:10 am-5:30 pm
2 stops10h 20m
Columbus
Tue 7/21
12:55 pm-9:20 pm
2 stops8h 25m
$281
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Tue 6/30
12:45 pm-10:50 pm
2 stops10h 05m
Columbus
Sat 7/4
8:55 am-11:50 am
1 stop2h 55m
$304
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Wed 7/15
8:10 am-5:30 pm
2 stops9h 20m
Columbus
Mon 7/20
11:55 am-10:35 pm
2 stops10h 40m
$311
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Sat 7/11
7:00 am-12:15 pm
1 stop5h 15m
Columbus
Tue 7/14
5:40 am-12:05 pm
2 stops6h 25m
$326
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Tue 8/18
6:02 pm-11:59 pm
1 stop5h 57m
Columbus
Wed 8/19
11:05 am-4:58 pm
1 stop5h 53m
$335
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Sat 7/4
12:30 pm-7:05 pm
1 stop6h 35m
Columbus
Sat 7/11
6:50 am-11:55 am
1 stop5h 05m
$338
Quickest round-trip
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Thu 7/9
3:59 pm-9:02 pm
1 stop5h 03m
Columbus
Sun 7/12
8:08 pm-11:52 pm
1 stop3h 44m
$357
Cheapest one-way
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Mon 8/3
12:53 pm-4:59 pm
2 stops28h 06m
$125
Quickest one-way
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Sat 8/1
8:05 pm-11:56 pm
1 stop3h 51m
$169
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Sat 8/1
8:40 pm-12:43 pm
3 stops16h 03m
$275
Sorted by cheapest first
Best time to book a flight from Knoxville to Columbus
Have a flexible travel schedule? Discover the best time to fly to Columbus from Knoxville with our price prediction graph.
TYS-C01
TYS-CMH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Columbus
TYS-C01
TYS-CMH
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Columbus
Get insights into the airlines that provide service to Columbus. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Columbus. Reviews last updated June 18, 2026.
Read reviews from past customers who have flown United Airlines and American Airlines from Knoxville to Columbus. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.3
Boarding
7.7
Overall
7.4
Entertainment
7.1
Food
6.6
Crew
8.1
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Comfort
7.3
Boarding
7.7
Overall
7.4
Entertainment
7.1
Food
6.6
Crew
8.1
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Comfort
7.3
Boarding
7.7
Overall
7.4
Entertainment
7.1
Food
6.6
Crew
8.1
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Columbus. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Knoxville and Columbus flights
Browse other Knoxville and Columbus flight options. Last updated on June 18, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on June 18, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Columbus
Discover the top 2 airlines that operate flights from Knoxville to Columbus. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$326 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$294 | Average$361 | FlexibilityNo cancel fee | On-time69% |