$128+ Cheap flights from Knoxville (TYS) to Columbus
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CMH
Jul 4 — Jul 111
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Knoxville to Columbus with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Columbus
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to ColumbusExplore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 4, 2026.
Explore the most affordable flight options available from Knoxville to Columbus. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 4, 2026.
This United Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/267:00 am
TYS
- CMH
1 stop6h 06m
United Airlines
Sat 8/292:12 pm
CMH
- TYS
1 stop6h 41m
United Airlines
Deal found 6/1![United Airlines logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1310:05 pm
TYS
- CMH
1 stop12h 03m
Multiple Airlines
Fri 7/176:45 pm
CMH
- TYS
2 stops15h 17m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$312
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:00 am
TYS
- CMH
1 stop3h 44m
American Airlines
Thu 7/236:00 am
CMH
- TYS
1 stop5h 45m
American Airlines
Deal found 6/3![American Airlines logo]()
$318
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:45 pm
TYS
- CMH
2 stops6h 45m
Southwest
Tue 7/74:20 pm
CMH
- TYS
1 stop5h 00m
Southwest
Deal found 6/1![Southwest logo]()
$323
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/292:45 pm
TYS
- CMH
1 stop6h 35m
Southwest
Fri 8/78:05 am
CMH
- TYS
2 stops10h 30m
Southwest
Deal found 5/31![Southwest logo]()
$329
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/218:10 am
TYS
- CMH
2 stops9h 20m
Southwest
Thu 7/235:45 pm
CMH
- TYS
1 stop3h 30m
Southwest
Deal found 6/3![Southwest logo]()
$333
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/137:17 pm
TYS
- CMH
1 stop4h 33m
American Airlines
Fri 7/174:48 pm
CMH
- TYS
1 stop4h 45m
American Airlines
Deal found 6/3![American Airlines logo]()
$337
Best flights from Knoxville to ColumbusDiscover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 4, 2026.
Discover carefully curated flight deals from Knoxville to Columbus that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 4, 2026.
This United Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/267:00 am
TYS
- CMH
1 stop6h 06m
United Airlines
Sat 8/292:12 pm
CMH
- TYS
1 stop6h 41m
United Airlines
Deal found 6/1![United Airlines logo]()
$294
This American Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/2311:18 am
TYS
- CMH
1 stop4h 43m
American Airlines
Tue 6/308:03 am
CMH
- TYS
1 stop4h 32m
American Airlines
Deal found 5/30![American Airlines logo]()
$299
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:55 pm
TYS
- CMH
1 stop3h 05m
Southwest
Tue 7/76:00 am
CMH
- TYS
1 stop8h 05m
Southwest
Deal found 6/1![Southwest logo]()
$299
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/295:40 am
TYS
- CMH
1 stop3h 22m
Delta
Fri 8/712:10 pm
CMH
- TYS
1 stop5h 25m
Delta
Deal found 5/31![Delta logo]()
$318
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/292:45 pm
TYS
- CMH
1 stop6h 35m
Southwest
Fri 8/78:05 am
CMH
- TYS
2 stops10h 30m
Southwest
Deal found 5/31![Southwest logo]()
$329
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/218:10 am
TYS
- CMH
2 stops9h 20m
Southwest
Thu 7/235:45 pm
CMH
- TYS
1 stop3h 30m
Southwest
Deal found 6/3![Southwest logo]()
$333
Last-minute flights from Knoxville to ColumbusDiscover last-minute flight deals from Knoxville to Columbus. Data last updated June 4, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Columbus. Data last updated June 4, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:22 pm
TYS
- CMH
2 stops18h 51m
Multiple Airlines
Fri 6/1912:16 pm
CMH
- TYS
1 stop9h 34m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$392
This American Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/237:32 am
TYS
- CMH
1 stop4h 13m
American Airlines
Tue 6/308:20 am
CMH
- TYS
1 stop4h 23m
American Airlines
Deal found 6/2![American Airlines logo]()
$299
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:45 pm
TYS
- CMH
2 stops6h 45m
Southwest
Tue 7/74:20 pm
CMH
- TYS
1 stop5h 00m
Southwest
Deal found 6/1![Southwest logo]()
$323
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1310:05 pm
TYS
- CMH
1 stop12h 03m
Multiple Airlines
Fri 7/176:45 pm
CMH
- TYS
2 stops15h 17m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$312
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/137:17 pm
TYS
- CMH
1 stop4h 33m
American Airlines
Fri 7/174:48 pm
CMH
- TYS
1 stop4h 45m
American Airlines
Deal found 6/3![American Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/206:40 am
TYS
- CMH
2 stops11h 45m
Southwest
Sat 7/253:15 pm
CMH
- TYS
1 stop4h 25m
Southwest
Deal found 6/3![Southwest logo]()
$378
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:00 am
TYS
- CMH
1 stop3h 44m
American Airlines
Thu 7/236:00 am
CMH
- TYS
1 stop5h 45m
American Airlines
Deal found 6/3![American Airlines logo]()
$318
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/218:10 am
TYS
- CMH
2 stops9h 20m
Southwest
Thu 7/235:45 pm
CMH
- TYS
1 stop3h 30m
Southwest
Deal found 6/3![Southwest logo]()
$333
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/292:45 pm
TYS
- CMH
1 stop6h 35m
Southwest
Fri 8/78:05 am
CMH
- TYS
2 stops10h 30m
Southwest
Deal found 5/31![Southwest logo]()
$329
One-way flights from Knoxville to ColumbusSearch for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated June 4, 2026.
Search for one-way flight options from Knoxville to Columbus. Find affordable one-way fares based on user searches. Data last updated June 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1712:50 pm
TYS
- CMH
1 stop6h 15m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/2212:40 pm
TYS
- CMH
2 stops28h 25m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$152
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:00 pm
TYS
- CMH
1 stop8h 05m
Southwest
Deal found 6/1![Southwest logo]()
$158
This Kiwi.com deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/2912:49 pm
TYS
- CMH
2 stops28h 16m
Multiple Airlines
Deal found 5/30![Multiple Airlines logo]()
$166
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/167:15 am
TYS
- CMH
2 stops9h 44m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$169
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/227:59 pm
TYS
- CMH
1 stop3h 53m
American Airlines
Deal found 6/1![American Airlines logo]()
$189
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1911:18 am
TYS
- CMH
1 stop4h 43m
American Airlines
Deal found 6/3![American Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/199:59 pm
TYS
- CMH
3 stops41h 33m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$281
Find flight deals from Knoxville to Columbus
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Columbus (C01). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 4, 2026.
Round-trip from | $294 (United Airlines) |
|---|---|
One-way from | $128 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Columbus that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 4, 2026.
Use the filters below to find and compare flights from Knoxville to Columbus that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Wed 8/26
7:00 am-1:06 pm
1 stop6h 06m
Columbus
Sat 8/29
2:12 pm-8:53 pm
1 stop6h 41m
$294
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Tue 6/23
11:18 am-4:01 pm
1 stop4h 43m
Columbus
Tue 6/30
8:03 am-12:35 pm
1 stop4h 32m
$299
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Wed 7/1
6:55 pm-10:00 pm
1 stop3h 05m
Columbus
Tue 7/7
6:00 am-2:05 pm
1 stop8h 05m
$299
Quickest round-trip
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Wed 7/29
5:40 am-9:02 am
1 stop3h 22m
Columbus
Fri 8/7
12:10 pm-5:35 pm
1 stop5h 25m
$318
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Wed 7/29
2:45 pm-9:20 pm
1 stop6h 35m
Columbus
Fri 8/7
8:05 am-6:35 pm
2 stops10h 30m
$329
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Tue 7/21
8:10 am-5:30 pm
2 stops9h 20m
Columbus
Thu 7/23
5:45 pm-9:15 pm
1 stop3h 30m
$333
Cheapest one-way
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Mon 8/17
12:50 pm-7:05 pm
1 stop6h 15m
$128
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Mon 6/22
12:40 pm-5:05 pm
2 stops28h 25m
$152
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Mon 6/29
7:15 am-11:27 am
1 stop4h 12m
$169
KnoxvilleColumbus
TYS - CMH
TYSCMH
Knoxville McGhee Tyson
Mon 10/19
8:15 am-3:00 pm
2 stops6h 45m
$174
Showing 1-10 of 15 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Columbus
Have a flexible travel schedule? Discover the best time to fly to Columbus from Knoxville with our price prediction graph.
TYS-C01
TYS-CMH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Columbus
TYS-C01
TYS-CMH
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Columbus
Get insights into the airlines that provide service to Columbus. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Columbus. Reviews last updated June 4, 2026.
Read reviews from past customers who have flown United Airlines and American Airlines from Knoxville to Columbus. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.7
Comfort
7.3
Crew
8.1
Overall
7.4
Entertainment
7.1
Food
6.6
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Boarding
7.7
Comfort
7.3
Crew
8.1
Overall
7.4
Entertainment
7.1
Food
6.6
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Boarding
7.7
Comfort
7.3
Crew
8.1
Overall
7.4
Entertainment
7.1
Food
6.6
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Columbus. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Knoxville
Popular flights
Alternative routes for Knoxville to Columbus
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Columbus by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Columbus by cabin class
Find flights from Knoxville to Columbus, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Columbus flights
Browse other Knoxville and Columbus flight options. Last updated on June 4, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on June 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Columbus
Discover the top 2 airlines that operate flights from Knoxville to Columbus. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$326 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$294 | Average$361 | FlexibilityNo cancel fee | On-time69% |