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Columbia

$331+ Cheap flights from South Carolina to Columbia, MO (COU)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/28. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — COU
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from South Carolina to Columbia

Keep the following information in mind while searching for South Carolina to Columbia flight deals. Data was last updated September 15, 2025.

Round-trip from

$331
(American Airlines)
From South Carolina to Columbia Regional
Search Deals

Find flight deals from South Carolina to Columbia

Cheapest flights from South Carolina to Columbia
Explore the most affordable flight options available from South Carolina to Columbia. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/288:20 amCLT - COU
1 stop5h 59mAmerican Airlines
Tue 11/46:17 pmCOU - CLT
1 stop5h 10mAmerican Airlines
Deal found 9/13$331
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/118:20 amCLT - COU
1 stop5h 59mAmerican Airlines
Sat 10/1812:15 pmCOU - CLT
1 stop6h 03mAmerican Airlines
Deal found 9/13$354
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/3010:20 amCLT - COU
1 stop6h 33mAmerican Airlines
Sat 10/46:24 amCOU - CLT
1 stop4h 18mAmerican Airlines
Deal found 9/15$378
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:00 amCAE - COU
2 stops11h 44mAmerican Airlines
Sat 10/46:24 amCOU - CAE
2 stops11h 12mAmerican Airlines
Deal found 9/14$417
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/172:56 pmAGS - COU
2 stops7h 35mAmerican Airlines
Mon 10/2011:37 amCOU - AGS
2 stops8h 53mAmerican Airlines
Deal found 9/14$497
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1010:42 pmCLT - COU
1 stop13h 25mAmerican Airlines
Mon 10/137:49 pmCOU - CLT
1 stop13h 29mAmerican Airlines
Deal found 9/14$514
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/173:42 pmCAE - COU
1 stop23h 35mUnited Airlines
Mon 10/202:52 pmCOU - CAE
2 stops22h 26mUnited Airlines
Deal found 9/13$522
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1010:42 pmCLT - COU
1 stop13h 25mAmerican Airlines
Sun 10/127:49 pmCOU - CLT
1 stop11h 36mAmerican Airlines
Deal found 9/14$523
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:30 amCLT - COU
1 stop8h 47mUnited Airlines
Sat 10/48:00 amCOU - CLT
2 stops24h 53mUnited Airlines
Deal found 9/15$537
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/194:17 pmCLT - COU
1 stop5h 04mAmerican Airlines
Mon 9/2212:28 pmCOU - CLT
1 stop7h 14mAmerican Airlines
Deal found 9/13$550
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/107:46 pmCLT - COU
2 stops26h 41mUnited Airlines
Mon 10/138:00 amCOU - CLT
1 stop25h 31mUnited Airlines
Deal found 9/14$582
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/112:00 pmCHS - COU
1 stop5h 44mAmerican Airlines
Thu 10/24:23 pmCOU - CHS
1 stop5h 08mAmerican Airlines
Deal found 9/15$790

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Columbia that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from South Carolina to Columbia that are best for you.

Fly from

South Carolina

Fly to

Columbia

Route

Depart

Return

Price

CharlotteColumbia

CLT - COU

CLTCOU

Charlotte Douglas

Tue 10/28

8:20 am-1:19 pm

1 stop5h 59m

Columbia Regional

Tue 11/4

6:17 pm-12:27 am

1 stop5h 10m

$331

CharlotteColumbia

CLT - COU

CLTCOU

Charlotte Douglas

Sat 10/11

8:20 am-1:19 pm

1 stop5h 59m

Columbia Regional

Sat 10/18

12:15 pm-7:18 pm

1 stop6h 03m

$354

CharlotteColumbia

CLT - COU

CLTCOU

Charlotte Douglas

Tue 9/30

10:20 am-3:53 pm

1 stop6h 33m

Columbia Regional

Sat 10/4

6:24 am-11:42 am

1 stop4h 18m

$378

ColumbiaColumbia

CAE - COU

CAECOU

Columbia Metropolitan

Tue 9/30

6:00 am-4:44 pm

2 stops11h 44m

Columbia Regional

Sat 10/4

6:24 am-6:36 pm

2 stops11h 12m

$417

AugustaColumbia

AGS - COU

AGSCOU

Augusta Bush Field

Fri 10/17

2:56 pm-9:31 pm

2 stops7h 35m

Columbia Regional

Mon 10/20

11:37 am-9:30 pm

2 stops8h 53m

$497

ColumbiaColumbia

CAE - COU

CAECOU

Columbia Metropolitan

Fri 10/17

3:42 pm-2:17 pm

1 stop23h 35m

Columbia Regional

Mon 10/20

2:52 pm-2:18 pm

2 stops22h 26m

$522

CharlotteColumbia

CLT - COU

CLTCOU

Charlotte Douglas

Fri 10/10

10:42 pm-11:07 am

1 stop13h 25m

Columbia Regional

Sun 10/12

7:49 pm-8:25 am

1 stop11h 36m

$523

CharlotteColumbia

CLT - COU

CLTCOU

Charlotte Douglas

Tue 9/30

6:30 am-2:17 pm

1 stop8h 47m

Columbia Regional

Sat 10/4

8:00 am-9:53 am

2 stops24h 53m

$537

CharlotteColumbia

CLT - COU

CLTCOU

Charlotte Douglas

Fri 9/19

4:17 pm-8:21 pm

1 stop5h 04m

Columbia Regional

Mon 9/22

12:28 pm-8:42 pm

1 stop7h 14m

$550

CharlotteColumbia

CLT - COU

CLTCOU

Charlotte Douglas

Fri 10/10

7:46 pm-9:27 pm

2 stops26h 41m

Columbia Regional

Mon 10/13

8:00 am-10:31 am

1 stop25h 31m

$582

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 17 results
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Best time to book a flight from South Carolina to Columbia

Have a flexible travel schedule? Discover the best time to fly to Columbia from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Columbia
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Columbia. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Columbia from South Carolina?

    Columbia Regional (COU), located 11.1 mi from the city center, is the airport you fly into when you book flights from South Carolina to Columbia.

  • How long is the flight from South Carolina to Columbia, Missouri?

    Departing from South Carolina to Columbia, Missouri will take you 5h 59m. South Carolina and Columbia, Missouri are separated by a distance of 669 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from South Carolina to Columbia, Missouri?

    While some choose either Charlotte Douglas - Columbia Regional or Charleston - Columbia Regional, Columbia Metropolitan - Columbia Regional is the most popular route from South Carolina to Columbia, Missouri.

  • Can I find deals for flights from South Carolina to Columbia that include hotel bookings?

    Yes. In addition to deals on South Carolina to Columbia flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Columbia?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Columbia.

  • Can I find deals for business class flights from South Carolina to Columbia?

    Yes. Cheapflights offers flight deals from South Carolina to Columbia by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Columbia, Missouri?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Columbia, Missouri (average of $362). Flying from South Carolina to Columbia, Missouri in March is currently the most expensive (average of $571). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Columbia?

Book flights to Columbia if you plan to visit one of these locations
Jefferson City

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Alternative routes for South Carolina to Columbia

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