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$255+ Cheap flights from South Carolina to Columbia, MO (COU)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/29. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — COU
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from South Carolina to Columbia

Cheapest flights from South Carolina to Columbia
Explore the most affordable flight options available from South Carolina to Columbia. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1410:34 amCAE - COU
2 stops11h 17mUnited Airlines
Tue 11/189:00 amCOU - CAE
2 stops11h 30mUnited Airlines
Deal found 10/30$379
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:04 pmCLT - COU
1 stop4h 56mAmerican Airlines
Sat 12/1312:21 pmCOU - CLT
1 stop7h 14mAmerican Airlines
Deal found 10/29$400
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1110:00 amCLT - COU
2 stops12h 22mUnited Airlines
Sat 12/133:25 pmCOU - CLT
1 stop5h 14mUnited Airlines
Deal found 10/29$406
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/124:45 pmCLT - COU
1 stop6h 15mAmerican Airlines
Sun 12/147:06 amCOU - CLT
1 stop5h 35mAmerican Airlines
Deal found 10/29$470
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/249:25 amCLT - COU
1 stop5h 10mAmerican Airlines
Sun 11/307:06 pmCOU - CLT
1 stop7h 54mAmerican Airlines
Deal found 10/28$510
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/129:25 amCLT - COU
1 stop6h 43mAmerican Airlines
Sun 11/165:58 pmCOU - CLT
1 stop5h 20mAmerican Airlines
Deal found 10/28$519
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:00 amCLT - COU
2 stops9h 26mUnited Airlines
Sun 12/146:15 pmCOU - CLT
2 stops18h 56mUnited Airlines
Deal found 10/29$583

Cheap flight deals from South Carolina to Columbia

Keep the following information in mind while searching for South Carolina to Columbia flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$343
(United Airlines)

One-way from

$255
(American Airlines)
Provider with most accurate pricing for Myrtle Beach Intl-Columbia Regional flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Columbia Regional flights.
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From South Carolina to Columbia Regional
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One-way flight from South Carolina to Columbia Regional
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Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Columbia that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from South Carolina to Columbia that are best for you.

Fly from

South Carolina

Fly to

Columbia

Route

Depart

Return

Price

CharlestonColumbia

CHS - COU

CHSCOU

Charleston

Wed 3/25

6:35 am-10:18 am

1 stop4h 43m

Columbia Regional

Sat 3/28

3:16 pm-11:02 pm

1 stop6h 46m

$343

ColumbiaColumbia

CAE - COU

CAECOU

Columbia Metropolitan

Fri 11/14

10:34 am-8:51 pm

2 stops11h 17m

Columbia Regional

Tue 11/18

9:00 am-9:30 pm

2 stops11h 30m

$379

CharlotteColumbia

CLT - COU

CLTCOU

Charlotte Douglas

Thu 12/11

6:04 pm-10:00 pm

1 stop4h 56m

Columbia Regional

Sat 12/13

12:21 pm-8:35 pm

1 stop7h 14m

$400

CharlotteColumbia

CLT - COU

CLTCOU

Charlotte Douglas

Thu 12/11

10:00 am-9:22 pm

2 stops12h 22m

Columbia Regional

Sat 12/13

3:25 pm-9:39 pm

1 stop5h 14m

$406

ColumbiaColumbia

CAE - COU

CAECOU

Columbia Metropolitan

Wed 3/25

9:10 am-9:10 pm

2 stops13h 00m

Columbia Regional

Sat 3/28

3:16 pm-11:40 pm

2 stops7h 24m

$409

CharlotteColumbia

CLT - COU

CLTCOU

Charlotte Douglas

Fri 12/12

12:56 pm-7:05 pm

2 stops7h 09m

Columbia Regional

Sun 12/14

11:52 am-5:10 pm

1 stop4h 18m

$476

CharlotteColumbia

CLT - COU

CLTCOU

Charlotte Douglas

Mon 11/24

9:25 am-1:35 pm

1 stop5h 10m

Columbia Regional

Sun 11/30

7:06 pm-4:00 am

1 stop7h 54m

$510

CharlotteColumbia

CLT - COU

CLTCOU

Charlotte Douglas

Wed 11/12

9:25 am-3:08 pm

1 stop6h 43m

Columbia Regional

Sun 11/16

5:58 pm-12:18 am

1 stop5h 20m

$519

AugustaColumbia

AGS - COU

AGSCOU

Augusta Bush Field

Tue 3/24

7:00 am-11:34 am

1 stop5h 34m

Columbia Regional

Sat 3/28

7:19 am-3:36 pm

1 stop7h 17m

$534

ColumbiaColumbia

CAE - COU

CAECOU

Columbia Metropolitan

Wed 3/25

7:08 am-11:34 am

1 stop5h 26m

Columbia Regional

Sat 3/28

5:47 pm-11:57 pm

1 stop5h 10m

$578

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 16 results
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Best time to book a flight from South Carolina to Columbia

Have a flexible travel schedule? Discover the best time to fly to Columbia from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Columbia
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Columbia. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Columbia from South Carolina?

    Columbia Regional (COU), located 11.1 mi from the city center, is the airport you fly into when you book flights from South Carolina to Columbia.

  • How long is the flight from South Carolina to Columbia, Missouri?

    Departing from South Carolina to Columbia, Missouri will take you 4h 43m. South Carolina and Columbia, Missouri are separated by a distance of 794 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from South Carolina to Columbia, Missouri?

    While some choose either Columbia Metropolitan - Columbia Regional or Charleston - Columbia Regional, Charlotte Douglas - Columbia Regional is the most popular route from South Carolina to Columbia, Missouri.

  • Can I find deals for flights from South Carolina to Columbia that include hotel bookings?

    Yes. In addition to deals on South Carolina to Columbia flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Columbia?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Columbia.

  • Can I find deals for business class flights from South Carolina to Columbia?

    Yes. Cheapflights offers flight deals from South Carolina to Columbia by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Columbia?

Book flights to Columbia if you plan to visit one of these locations
Jefferson City

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