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South Carolina

$122+ Cheap flights from Columbia, MO (COU) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/25. Fares are subject to change and may not be available on all flights or dates of travel.
COU — CHS
Jul 22 — Jul 291
Wed 7/22
Wed 7/29
1 adult, Economy
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Cheap flight deals from Columbia to South Carolina

Cheapest flights from Columbia to South Carolina
Explore the most affordable flight options available from Columbia to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 22, 2026.

This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/185:48 pm
COU
-
CHS
1 stop13h 50m
Multiple Airlines
Tue 7/213:13 pm
CHS
-
COU
1 stop20h 41m
Multiple Airlines
Deal found 6/17$252
This American Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:20 am
COU
-
HHH
1 stop5h 56m
American Airlines
Tue 7/212:03 pm
HHH
-
COU
1 stop4h 58m
American Airlines
Deal found 6/18$298
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/912:24 pm
COU
-
CHS
1 stop4h 43m
American Airlines
Sat 11/146:32 pm
CHS
-
COU
1 stop5h 03m
American Airlines
Deal found 6/21$298
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/193:11 pm
COU
-
CHS
1 stop5h 23m
United Airlines
Mon 8/242:54 pm
CHS
-
COU
2 stops9h 01m
United Airlines
Deal found 6/17$304
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/211:33 am
COU
-
CHS
1 stop20h 05m
Multiple Airlines
Thu 11/52:13 pm
CHS
-
COU
1 stop22h 55m
Multiple Airlines
Deal found 6/20$305
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1511:44 am
COU
-
CHS
1 stop19h 54m
Multiple Airlines
Tue 7/213:13 pm
CHS
-
COU
1 stop20h 41m
Multiple Airlines
Deal found 6/17$307
This United Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/13:25 pm
COU
-
CHS
1 stop5h 23m
United Airlines
Thu 8/66:00 am
CHS
-
COU
1 stop5h 13m
United Airlines
Deal found 6/20$313
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1511:44 am
COU
-
CLT
1 stop28h 14m
Multiple Airlines
Fri 7/1710:59 pm
CLT
-
COU
1 stop18h 59m
Multiple Airlines
Deal found 6/18$328
This United Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:15 am
COU
-
MYR
1 stop7h 02m
United Airlines
Tue 9/295:00 pm
MYR
-
COU
1 stop6h 55m
United Airlines
Deal found 6/20$328
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1511:44 am
COU
-
CLT
1 stop22h 45m
Multiple Airlines
Tue 7/2112:24 pm
CLT
-
COU
1 stop23h 30m
Multiple Airlines
Deal found 6/18$332
This American Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:20 am
COU
-
MYR
1 stop5h 02m
American Airlines
Wed 7/224:43 pm
MYR
-
COU
1 stop6h 37m
American Airlines
Deal found 6/19$343
This United Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:15 am
COU
-
CHS
2 stops7h 35m
United Airlines
Mon 9/144:58 pm
CHS
-
COU
1 stop6h 57m
United Airlines
Deal found 6/18$349

Find flight deals from Columbia to South Carolina

Keep the following information in mind while searching for Columbia to South Carolina flight deals. Data was last updated June 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$252
(Kiwi.com)

One-way from

$122
(Kiwi.com)
Provider with most accurate pricing for Columbia Regional-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Columbia Regional-Myrtle Beach Intl flights.
Search Deals
From Columbia Regional to South Carolina
Search Deals
One-way flight from Columbia Regional to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 22, 2026.
Use the filters below to find and compare flights from Columbia to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbiaHilton Head Island

COU - HHH

COUHHH

Columbia Regional

Wed 7/15

7:20 am-2:16 pm

1 stop5h 56m

Hilton Head Island

Tue 7/21

2:03 pm-6:01 pm

1 stop4h 58m

$298

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Wed 8/19

6:15 am-1:58 pm

1 stop6h 43m

Charleston

Mon 8/24

4:28 pm-10:55 pm

1 stop7h 27m

$298

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Tue 11/10

12:24 pm-6:07 pm

1 stop4h 43m

Charleston

Sat 11/14

6:32 pm-10:35 pm

1 stop5h 03m

$298

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Tue 9/22

6:15 am-2:17 pm

1 stop7h 02m

Myrtle Beach Intl

Tue 9/29

5:00 pm-10:55 pm

1 stop6h 55m

$328

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Tue 8/11

6:15 am-2:53 pm

1 stop7h 38m

Myrtle Beach Intl

Tue 8/18

6:21 pm-10:55 pm

1 stop5h 34m

$343

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Sat 10/31

8:00 am-1:58 pm

1 stop4h 58m

Charleston

Fri 11/6

7:00 am-8:30 pm

2 stops14h 30m

$384

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Tue 7/14

3:25 pm-9:48 pm

1 stop5h 23m

Charleston

Tue 7/21

3:34 pm-11:33 pm

2 stops8h 59m

$384

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Mon 9/7

6:00 am-11:34 am

1 stop4h 34m

Myrtle Beach Intl

Sun 9/13

6:15 pm-10:34 pm

1 stop5h 19m

$388

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Tue 11/10

9:00 am-11:48 pm

2 stops13h 48m

Charleston

Sat 11/14

7:00 am-8:30 pm

2 stops14h 30m

$389

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Sat 8/29

6:15 am-2:17 pm

1 stop7h 02m

Myrtle Beach Intl

Wed 9/2

6:21 pm-10:55 pm

1 stop5h 34m

$393

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/19

Showing 1-10 of 42 resultsSorted by cheapest first
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5

Best time to book a flight from Columbia to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbia to South Carolina
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated June 22, 2026.
See what other customers who have flown with American Airlines from Columbia to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,739 reviews

Boarding

7.5

Overall

7.1

Crew

7.9

Comfort

7.2

Entertainment

6.8

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Apr 2026

DFW - BDL

They keep changing the gate, delaying the hours and then finally canceled it. No accomodation, no food, nothing!
American Airlines
7.1
Good
11,739 reviews
American Airlines
7.1
Good
11,739 reviews

Boarding

7.5

Overall

7.1

Crew

7.9

Comfort

7.2

Entertainment

6.8

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Anonymous,Apr 2026

DFW - BDL

They keep changing the gate, delaying the hours and then finally canceled it. No accomodation, no food, nothing!

Related info for your journey

Find useful and relevant information for your journey from Columbia to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Columbia to South Carolina?

    Columbia Regional (COU), located 11.1 mi from the city center, is the airport you fly out of when you book flights from Columbia to South Carolina.

  • How long is the flight from Columbia, Missouri to South Carolina?

    Departing from Columbia, Missouri to South Carolina will take you 5h 56m. There are 791 mi between Columbia, Missouri and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Columbia, Missouri to South Carolina?

    When deciding which route to take from Columbia, Missouri to South Carolina consider Columbia Regional - Charlotte Douglas, Columbia Regional - Charleston or Columbia Regional - Myrtle Beach Intl as they are the most popular.

  • Can I find deals for flights from Columbia to South Carolina that include hotel bookings?

    Yes. In addition to deals on Columbia to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to South Carolina.

  • Can I find deals for business class flights from Columbia to South Carolina?

    Yes. Cheapflights offers flight deals from Columbia to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Columbia to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Columbia to South Carolina

Discover the top airline that operate flights from Columbia to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 22, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$323Average$489FlexibilityNo cancel feeOn-time71%

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