$228+ Cheap flights from Columbia, MO (COU) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/20. Fares are subject to change and may not be available on all flights or dates of travel.
COU — CHS
Oct 22 — Oct 291
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Columbia to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Columbia to South Carolina
Cheapest
Best
Last-minute
One-way
Cheapest flights from Columbia to South CarolinaExplore the most affordable flight options available from Columbia to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
Explore the most affordable flight options available from Columbia to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:26 pm -
1 stop4h 54m
Thu 11/124:59 pm -
1 stop6h 43m
Deal found 9/18![American Airlines logo]()
$328
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/108:12 am -
1 stop4h 02m
Tue 11/175:10 pm -
1 stop5h 33m
Deal found 9/20![American Airlines logo]()
$328
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:15 am -
1 stop6h 49m
Wed 10/144:58 pm -
1 stop6h 57m
Deal found 9/18![United Airlines logo]()
$343
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/63:43 pm -
1 stop4h 34m
Sat 10/106:20 am -
1 stop5h 19m
Deal found 9/21![United Airlines logo]()
$358
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:44 am -
1 stop6h 32m
Sat 10/36:44 am -
1 stop5h 45m
Deal found 9/18![American Airlines logo]()
$388
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:59 pm -
1 stop18h 39m
Sun 10/252:13 pm -
1 stop21h 30m
Deal found 9/21![Multiple Airlines logo]()
$398
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/38:16 am -
1 stop3h 54m
Mon 10/56:02 pm -
1 stop5h 37m
Deal found 9/22![American Airlines logo]()
$418
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:17 am -
1 stop5h 35m
Tue 10/273:45 pm -
1 stop6h 10m
Deal found 9/21![American Airlines logo]()
$428
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2411:19 am -
1 stop4h 38m
Tue 10/275:37 pm -
1 stop6h 21m
Deal found 9/21![United Airlines logo]()
$428
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/73:00 pm -
2 stops7h 59m
Thu 11/127:00 pm -
1 stop4h 58m
Deal found 9/22![United Airlines logo]()
$434
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2411:19 am -
1 stop4h 38m
Wed 10/2812:21 pm -
2 stops11h 37m
Deal found 9/21![United Airlines logo]()
$434
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:15 am -
2 stops11h 33m
Tue 10/277:00 am -
2 stops14h 41m
Deal found 9/21![United Airlines logo]()
$439
Best flights from Columbia to South CarolinaDiscover carefully curated flight deals from Columbia to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
Discover carefully curated flight deals from Columbia to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/108:12 am -
1 stop4h 02m
Tue 11/175:10 pm -
1 stop5h 33m
Deal found 9/20![American Airlines logo]()
$328
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/2111:30 am -
2 stops10h 49m
Mon 1/252:30 pm -
2 stops9h 52m
Deal found 9/18![United Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/38:16 am -
1 stop3h 54m
Mon 10/56:02 pm -
1 stop5h 37m
Deal found 9/22![American Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2411:19 am -
1 stop4h 38m
Wed 10/285:37 pm -
1 stop6h 21m
Deal found 9/21![United Airlines logo]()
$428
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/33:00 pm -
1 stop6h 00m
Sat 11/78:30 am -
2 stops13h 11m
Deal found 9/18![United Airlines logo]()
$434
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/23:00 pm -
2 stops7h 59m
Tue 11/107:00 pm -
1 stop4h 58m
Deal found 9/18![United Airlines logo]()
$434
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:26 pm -
1 stop4h 51m
Sun 11/154:59 pm -
1 stop6h 43m
Deal found 9/21![American Airlines logo]()
$506
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/73:00 pm -
2 stops7h 59m
Thu 11/127:00 pm -
1 stop4h 58m
Deal found 9/22![United Airlines logo]()
$434
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/611:30 am -
2 stops10h 49m
Sat 1/92:30 pm -
2 stops9h 52m
Deal found 9/21![United Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/308:00 am -
2 stops7h 49m
Wed 2/311:28 am -
2 stops12h 54m
Deal found 9/20![United Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:12 am -
1 stop6h 14m
Mon 10/266:08 pm -
1 stop5h 31m
Deal found 9/19![American Airlines logo]()
$629
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:15 am -
2 stops11h 48m
Tue 10/2712:21 pm -
2 stops11h 37m
Deal found 9/21![United Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:47 am -
2 stops7h 57m
Sat 11/1412:29 pm -
2 stops10h 14m
Deal found 9/18![American Airlines logo]()
$633
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:15 am -
2 stops7h 09m
Sat 10/3110:16 am -
2 stops11h 25m
Deal found 9/21![United Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:15 am -
2 stops7h 06m
Sat 11/1412:29 pm -
2 stops10h 14m
Deal found 9/18![American Airlines logo]()
$634
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/63:43 pm -
1 stop4h 34m
Sat 10/2410:45 am -
2 stops10h 48m
Deal found 9/21![United Airlines logo]()
$449
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:19 am -
1 stop4h 46m
Mon 10/56:20 am -
1 stop5h 19m
Deal found 9/18![United Airlines logo]()
$458
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:26 pm -
2 stops18h 55m
Mon 11/1612:25 pm -
2 stops22h 23m
Deal found 9/18![American Airlines logo]()
$672
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:15 am -
2 stops7h 06m
Mon 11/164:17 pm -
1 stop7h 25m
Deal found 9/18![American Airlines logo]()
$680
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/53:43 pm -
1 stop4h 34m
Wed 10/215:46 pm -
1 stop6h 09m
Deal found 9/21![United Airlines logo]()
$473
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:15 am -
2 stops7h 11m
Sat 10/3110:37 am -
1 stop4h 41m
Deal found 9/21![United Airlines logo]()
$479
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:43 pm -
2 stops7h 32m
Thu 10/297:00 am -
2 stops8h 18m
Deal found 9/21![United Airlines logo]()
$484
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2411:19 am -
2 stops11h 40m
Thu 10/297:00 am -
2 stops14h 41m
Deal found 9/21![United Airlines logo]()
$484
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/293:00 pm -
1 stop5h 02m
Sat 10/3110:16 am -
2 stops11h 25m
Deal found 9/21![United Airlines logo]()
$512
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:15 am -
2 stops7h 11m
Sat 10/3110:37 am -
2 stops11h 04m
Deal found 9/21![United Airlines logo]()
$517
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:15 am -
2 stops7h 11m
Tue 10/2710:37 am -
2 stops11h 04m
Deal found 9/21![United Airlines logo]()
$517
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/53:43 pm -
1 stop4h 34m
Tue 10/206:00 am -
2 stops10h 08m
Deal found 9/21![United Airlines logo]()
$543
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:00 am -
2 stops8h 11m
Fri 10/305:54 pm -
2 stops27h 47m
Deal found 9/20![United Airlines logo]()
$607
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:15 am -
1 stop9h 42m
Sat 10/3110:16 am -
2 stops11h 25m
Deal found 9/21![United Airlines logo]()
$613
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:15 am -
2 stops7h 09m
Fri 10/307:54 pm -
2 stops15h 50m
Deal found 9/21![United Airlines logo]()
$618
Last-minute flights from Columbia to South CarolinaDiscover last-minute flight deals from Columbia to South Carolina. Data last updated September 22, 2026 and is based on user searches.
Discover last-minute flight deals from Columbia to South Carolina. Data last updated September 22, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:44 am -
1 stop6h 32m
Sat 10/36:44 am -
1 stop5h 45m
Deal found 9/18![American Airlines logo]()
$388
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/38:16 am -
1 stop3h 54m
Mon 10/56:02 pm -
1 stop5h 37m
Deal found 9/22![American Airlines logo]()
$418
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/52:49 pm -
2 stops20h 00m
Thu 10/222:43 pm -
1 stop22h 26m
Deal found 9/21![Multiple Airlines logo]()
$447
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/63:43 pm -
1 stop4h 34m
Sat 10/106:20 am -
1 stop5h 19m
Deal found 9/21![United Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/611:15 am -
1 stop4h 50m
Wed 10/216:20 am -
1 stop5h 19m
Deal found 9/21![United Airlines logo]()
$443
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:15 am -
1 stop6h 49m
Wed 10/144:58 pm -
1 stop6h 57m
Deal found 9/18![United Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:17 am -
1 stop5h 35m
Tue 10/273:45 pm -
1 stop6h 10m
Deal found 9/21![American Airlines logo]()
$428
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:15 am -
1 stop6h 49m
Tue 10/272:28 pm -
2 stops9h 30m
Deal found 9/21![United Airlines logo]()
$434
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2112:01 pm -
1 stop5h 27m
Sun 11/14:14 pm -
1 stop7h 01m
Deal found 9/21![American Airlines logo]()
$443
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:59 pm -
1 stop18h 39m
Sun 10/252:13 pm -
1 stop21h 30m
Deal found 9/21![Multiple Airlines logo]()
$398
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2411:19 am -
1 stop4h 38m
Tue 10/275:37 pm -
1 stop6h 21m
Deal found 9/21![United Airlines logo]()
$428
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:25 pm -
1 stop4h 34m
Sun 11/16:00 am -
1 stop4h 48m
Deal found 9/21![American Airlines logo]()
$443
One-way flights from Columbia to South CarolinaSearch for one-way flight options from Columbia to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
Search for one-way flight options from Columbia to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/204:53 pm -
1 stop19h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Allegiant Air logo]()
$228
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/108:12 am -
1 stop4h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![American Airlines logo]()
$278
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/217:12 am -
1 stop4h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![American Airlines logo]()
$344
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:12 am -
1 stop5h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![American Airlines logo]()
$373
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:15 am -
2 stops7h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![United Airlines logo]()
$379
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/212:44 pm -
3 stops45h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Allegiant Air logo]()
$387
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/204:53 pm -
3 stops24h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$400
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/217:45 am -
2 stops10h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![United Airlines logo]()
$472
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:00 pm -
3 stops41h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![United Airlines logo]()
$1,049
Find flight deals from Columbia to South Carolina
Keep the following information in mind while searching for Columbia to South Carolina flight deals. Data was last updated September 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $328 (American Airlines) |
One-way from | $228 (Kiwi.com) |
Popular in | October |
Cheapest in | January |
Average price | $491 |
Cheapflights Fare Finder
Customize your flight search to find flights from Columbia to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
Use the filters below to find and compare flights from Columbia to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
ColumbiaColumbia
COU Columbia Regional - CAE Columbia Metropolitan
COUCAE
Columbia Regional
Tue 11/10
8:12 am-1:14 pm
1 stop4h 02m
Columbia Metropolitan
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$278
ColumbiaColumbia
COU Columbia Regional - CAE Columbia Metropolitan
COUCAE
Columbia Regional
Tue 11/10
8:12 am-1:14 pm
1 stop4h 02m
Columbia Metropolitan
Tue 11/17
5:10 pm-9:43 pm
1 stop5h 33m
$328
ColumbiaCharleston
COU Columbia Regional - CHS Charleston
COUCHS
Columbia Regional
Thu 1/21
11:30 am-11:19 pm
2 stops10h 49m
Charleston
Mon 1/25
2:30 pm-11:22 pm
2 stops9h 52m
$339
ColumbiaColumbia
COU Columbia Regional - CAE Columbia Metropolitan
COUCAE
Columbia Regional
Tue 10/6
6:24 pm-11:59 pm
1 stop4h 35m
Columbia Metropolitan
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$373
ColumbiaColumbia
COU Columbia Regional - CAE Columbia Metropolitan
COUCAE
Columbia Regional
Mon 10/5
7:12 am-2:03 pm
1 stop5h 51m
Columbia Metropolitan
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$373
ColumbiaColumbia
COU Columbia Regional - CAE Columbia Metropolitan
COUCAE
Columbia Regional
Tue 10/6
6:15 am-2:26 pm
2 stops7h 11m
Columbia Metropolitan
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$379
ColumbiaGreenville
COU Columbia Regional - GSP Greenville
COUGSP
Columbia Regional
Sun 12/20
4:53 pm-6:45 pm
3 stops24h 52m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$400
ColumbiaGreenville
COU Columbia Regional - GSP Greenville
COUGSP
Columbia Regional
Sat 10/3
8:16 am-1:10 pm
1 stop3h 54m
Greenville
Mon 10/5
6:02 pm-10:39 pm
1 stop5h 37m
$418
ColumbiaColumbia
COU Columbia Regional - CAE Columbia Metropolitan
COUCAE
Columbia Regional
Sat 10/24
11:19 am-4:57 pm
1 stop4h 38m
Columbia Metropolitan
Wed 10/28
5:37 pm-10:58 pm
1 stop6h 21m
$428
ColumbiaCharleston
COU Columbia Regional - CHS Charleston
COUCHS
Columbia Regional
Tue 11/3
3:00 pm-10:00 pm
1 stop6h 00m
Charleston
Sat 11/7
8:30 am-8:41 pm
2 stops13h 11m
$434
Showing 1-10 of 37 resultsSorted by cheapest first
Best time to book a flight from Columbia to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Columbia with our price prediction graph.
COU-CHS
COU-CAE
COU-GSP
COU-MYR
COU-HHH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Columbia to South Carolina
COU-USSC
COU-CHS
COU-CAE
COU-GSP
COU-MYR
What is the cheapest month to book a flight from Columbia, Missouri to South Carolina?
Currently, January is the cheapest month in which you can book a flight from Columbia, Missouri to South Carolina (average of $258). Flying from Columbia, Missouri to South Carolina in October is currently the most expensive (average of $667). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Columbia, Missouri to South Carolina?
Airfare is below average for this route at the moment.
Columbia, Missouri to South Carolina flights typically cost between $410 and $646 in November.The cheapest round-trip price found within the last 5 days was $328 on American Airlines (Nov 7-Nov 12).
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 22, 2026.
See what other customers who have flown with United Airlines and American Airlines from Columbia to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.7
Comfort
7.3
Overall
7.4
Food
6.7
Crew
8.1
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Boarding
7.7
Comfort
7.3
Overall
7.4
Food
6.7
Crew
8.1
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Boarding
7.7
Comfort
7.3
Overall
7.4
Food
6.7
Crew
8.1
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Related info for your journey
Find useful and relevant information for your journey from Columbia to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Columbia to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Columbia to South Carolina by cabin class
Find flights from Columbia to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Columbia and South Carolina flights
Browse other Columbia and South Carolina flight options. Last updated on September 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Columbia to South Carolina flights
Consider these flights traveling from Columbia to South Carolina.
Top 2 airlines flying from Columbia to South Carolina
Discover the top 2 airlines that operate flights from Columbia to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$263 | Average$385 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$298 | Average$443 | FlexibilityNo cancel fee | On-time71% |