HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Central America

$268+ Cheap flights from Panama City, FL (ECP) to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/19. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — SJO
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to Central America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to Central America

Keep the following information in mind while searching for Panama City to Central America flight deals. Data was last updated September 11, 2025.

Round-trip from

$498
(American Airlines)

One-way from

$268
(Southwest)
From Panama City NW Florida Beaches to Central America
Search Deals
One-way flight from Panama City NW Florida Beaches to Central America
Search Deals

Find flight deals from Panama City to Central America

Cheapest flights from Panama City to Central America
Explore the most affordable flight options available from Panama City to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:32 amECP - SJO
2 stops14h 10mAmerican Airlines
Tue 3/1012:55 pmSJO - ECP
2 stops20h 05mAmerican Airlines
Deal found 9/10$498
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/211:47 pmECP - SJO
2 stops23h 13mAmerican Airlines
Sun 10/262:40 pmSJO - ECP
2 stops21h 32mAmerican Airlines
Deal found 9/9$521
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:00 amECP - PTY
1 stop6h 55mDelta
Tue 10/72:21 pmPTY - ECP
1 stop8h 49mDelta
Deal found 9/10$537
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:32 amECP - SJO
1 stop12h 25mAmerican Airlines
Sun 10/56:00 amSJO - ECP
2 stops27h 13mAmerican Airlines
Deal found 9/10$539
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:33 amECP - LIR
1 stop7h 46mAmerican Airlines
Wed 12/101:19 pmLIR - ECP
1 stop9h 51mAmerican Airlines
Deal found 9/10$546
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:30 amECP - PTY
1 stop12h 07mUnited Airlines
Tue 10/710:00 amPTY - ECP
1 stop11h 48mUnited Airlines
Deal found 9/11$547
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/303:29 pmECP - PTY
2 stops21h 26mAmerican Airlines
Tue 10/73:15 pmPTY - ECP
2 stops20h 13mAmerican Airlines
Deal found 9/10$552
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:00 amECP - LIR
1 stop6h 40mDelta
Sun 12/142:05 pmLIR - ECP
1 stop8h 53mDelta
Deal found 9/9$558
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/85:50 pmECP - LIR
2 stops20h 29mAmerican Airlines
Sun 12/143:14 pmLIR - ECP
2 stops20h 24mAmerican Airlines
Deal found 9/9$566
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/296:00 amECP - LIR
1 stop7h 00mDelta
Wed 10/11:25 pmLIR - ECP
1 stop8h 38mDelta
Deal found 9/8$601
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:30 amECP - SJO
1 stop6h 56mUnited Airlines
Tue 3/1011:35 amSJO - ECP
1 stop7h 17mUnited Airlines
Deal found 9/11$604
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:30 amECP - SJO
1 stop6h 56mUnited Airlines
Mon 9/297:55 amSJO - ECP
1 stop7h 21mUnited Airlines
Deal found 9/10$640

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Panama City to Central America that are best for you.

Fly from

Panama City

Fly to

Central America

Route

Depart

Return

Price

Panama CitySan José

ECP - SJO

ECPSJO

Panama City NW Florida Beaches

Tue 9/30

6:32 am-7:42 pm

2 stops14h 10m

San José Juan Santamaria Intl

Tue 3/10

12:55 pm-10:00 am

2 stops20h 05m

$498

Panama CitySan José

ECP - SJO

ECPSJO

Panama City NW Florida Beaches

Tue 10/21

1:47 pm-12:00 pm

2 stops23h 13m

San José Juan Santamaria Intl

Sun 10/26

2:40 pm-1:12 pm

2 stops21h 32m

$521

Panama CityPanama City

ECP - PTY

ECPPTY

Panama City NW Florida Beaches

Tue 9/30

6:00 am-12:55 pm

1 stop6h 55m

Panama City Tocumen Intl

Tue 10/7

2:21 pm-11:10 pm

1 stop8h 49m

$537

Panama CitySan José

ECP - SJO

ECPSJO

Panama City NW Florida Beaches

Wed 10/1

6:32 am-5:57 pm

1 stop12h 25m

San José Juan Santamaria Intl

Sun 10/5

6:00 am-10:13 am

2 stops27h 13m

$539

Panama CityLiberia

ECP - LIR

ECPLIR

Panama City NW Florida Beaches

Wed 12/3

6:33 am-2:19 pm

1 stop7h 46m

Liberia

Wed 12/10

1:19 pm-11:10 pm

1 stop9h 51m

$546

Panama CityPanama City

ECP - PTY

ECPPTY

Panama City NW Florida Beaches

Tue 9/30

6:30 am-6:37 pm

1 stop12h 07m

Panama City Tocumen Intl

Tue 10/7

10:00 am-9:48 pm

1 stop11h 48m

$547

Panama CityPanama City

ECP - PTY

ECPPTY

Panama City NW Florida Beaches

Tue 9/30

3:29 pm-12:55 pm

2 stops21h 26m

Panama City Tocumen Intl

Tue 10/7

3:15 pm-11:28 am

2 stops20h 13m

$552

Panama CityLiberia

ECP - LIR

ECPLIR

Panama City NW Florida Beaches

Mon 12/8

6:00 am-12:40 pm

1 stop6h 40m

Liberia

Sun 12/14

2:05 pm-10:58 pm

1 stop8h 53m

$558

Panama CityLiberia

ECP - LIR

ECPLIR

Panama City NW Florida Beaches

Mon 12/8

5:50 pm-2:19 pm

2 stops20h 29m

Liberia

Sun 12/14

3:14 pm-11:38 am

2 stops20h 24m

$566

Panama CitySan José

ECP - SJO

ECPSJO

Panama City NW Florida Beaches

Thu 1/8

6:48 am-11:00 pm

1 stop16h 12m

San José Juan Santamaria Intl

Thu 1/15

6:29 am-8:31 pm

1 stop14h 02m

$604

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 20 results
1
2

Best time to book a flight from Panama City to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Central America

What is the cheapest month to book a flight from Panama City, Florida to Central America?

Currently, September is the cheapest month in which you can book a flight from Panama City, Florida to Central America (average of $398). Flying from Panama City, Florida to Central America in March is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to CA?

Find hourly flight availability from Panama City to Central America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City, Florida to Central America as you normally would.

Reviews of airlines servicing Central America

Get insights into the airlines that provide service to Central America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Central America. Reviews last updated September 11, 2025.
Read through reviews of airlines operating flights from Panama City to Central America, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Central America?

    For a flight from Panama City to Central America, you will be flying from NW Florida Beaches. Panama City NW Florida Beaches (ECP) is just 16.0 mi from the center of the city.

  • How long is the flight from Panama City, Florida to Central America?

    There are many flights that can get you from Panama City, Florida to Central America in 6h 55m. Fly via American Airlines, Delta, or United Airlines to get the fastest option. There are 1527 mi between Panama City, Florida and Central America. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Panama City, Florida to Central America one-way?

    One-way options have recently been found by users for as low as $268 on Southwest. Other airlines that offer cheap prices include Delta from $283 and American Airlines from $284 one-way.

  • What are the most popular routes from Panama City, Florida to Central America?

    Most travelers choose Panama City NW Florida Beaches - San José Juan Santamaria Intl, Panama City NW Florida Beaches - Panama City Tocumen Intl or Panama City NW Florida Beaches - Liberia when deciding on the best route from Panama City, Florida to Central America.

  • Can I find deals for flights from Panama City to Central America that include hotel bookings?

    Yes. In addition to deals on Panama City to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Central America.

  • Can I find deals for business class flights from Panama City to Central America?

    Yes. Cheapflights offers flight deals from Panama City to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Central America?

    Currently, September is the cheapest month in which you can book a flight from Panama City, Florida to Central America (average of $398). Flying from Panama City, Florida to Central America in March is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Central America

See prices for flight routes from nearby airports that may be better suited for you.
Fort Lauderdale to LaGuardia flights
Fort Lauderdale to Newark flights
Miami to John F Kennedy Intl flights
Miami to LaGuardia flights
Miami to Newark flights
Fort Lauderdale to John F Kennedy Intl flights
Orlando to John F Kennedy Intl flights
Tampa to LaGuardia flights
Miami to Jose Maria Cordova Intl flights
Orlando to Las Vegas flights
Miami to Madrid flights
Tampa to John F Kennedy Intl flights
Orlando to Luis Munoz Marin Intl flights
Orlando to LaGuardia flights
Orlando to Newark flights
Fort Lauderdale to Atlanta flights
West Palm Beach to John F Kennedy Intl flights
Tampa to Newark flights
Fort Lauderdale to Las Vegas flights
Miami to Cancún flights
Tampa to Las Vegas flights
Miami to Los Angeles flights
Orlando to Denver flights
Orlando to Dallas/Fort Worth flights
Miami to Atlanta flights
Tampa to Boston flights
Fort Lauderdale to Cancún flights
Orlando to Boston flights
Miami to Mexico City flights
West Palm Beach to Newark flights
Miami to Ministro Pistarini flights
Miami to Lima flights
Fort Lauderdale to Dallas/Fort Worth flights
Miami to Bogotá flights
Tampa to Denver flights
Miami to Denver flights
Fort Lauderdale to Luis Munoz Marin Intl flights
Fort Lauderdale to Jose Maria Cordova Intl flights
Orlando to O'Hare Intl flights
Tampa to Luis Munoz Marin Intl flights
Miami to Las Vegas flights
Jacksonville to John F Kennedy Intl flights
Tampa to Seattle flights
Orlando to Los Angeles flights
West Palm Beach to LaGuardia flights
Fort Lauderdale to Boston flights
Orlando to Seattle flights
Fort Lauderdale to O'Hare Intl flights
Fort Lauderdale to Los Angeles flights
Miami to Dallas/Fort Worth flights

Top 3 airlines flying from Panama City to Central America

Discover the top 3 airlines that operate flights from Panama City to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$395Average$603FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$404Average$565FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$499Average$740FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.