It’s generally more expensive to depart on a Wednesday, if you have to leave on this day you can still search on Cheapflights to find great options that meet your needs.
Due to multiple factors, expect to potentially pay more when booking in December. For low rates, October can be a great choice for travel to Casper. Flights to Casper from Des Moines in October are about $323 on average during October, but can be found for as low as $245.
Unlike in the morning, when flights are generally more expensive, you can save up to 26% on flights from Des Moines to Casper by exploring options for tickets in the afternoon.