HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Buffalo

$368+ Cheap flights from Florence, SC to Buffalo (FLO - BUF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — BUF
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Florence to Buffalo with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Florence to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$368
(American Airlines)
From Florence to Buffalo
Search Deals

Find flight deals from Florence to Buffalo

Cheapest flights from Florence to Buffalo
Explore the most affordable flight options available from Florence to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/76:14 amFLO - BUF
2 stops10h 49mAmerican Airlines
Tue 10/1411:52 amBUF - FLO
2 stops11h 21mAmerican Airlines
Deal found 9/8$368
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/86:14 amFLO - BUF
1 stop6h 10mAmerican Airlines
Mon 10/137:38 pmBUF - FLO
1 stop4h 25mAmerican Airlines
Deal found 9/9$525
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/86:14 amFLO - BUF
2 stops5h 08mAmerican Airlines
Sun 10/127:38 pmBUF - FLO
1 stop4h 25mAmerican Airlines
Deal found 9/9$530
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/92:29 pmFLO - BUF
1 stop4h 23mAmerican Airlines
Mon 10/136:00 amBUF - FLO
1 stop4h 46mAmerican Airlines
Deal found 9/9$551
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/911:11 amFLO - BUF
2 stops7h 07mAmerican Airlines
Sun 10/126:11 amBUF - FLO
2 stops7h 53mAmerican Airlines
Deal found 9/9$620

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Florence to Buffalo that are best for you.

Fly from

Florence

Fly to

Buffalo

Route

Depart

Return

Price

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Tue 10/7

6:14 am-5:03 pm

2 stops10h 49m

Buffalo

Tue 10/14

11:52 am-11:13 pm

2 stops11h 21m

$368

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Wed 10/8

6:14 am-12:24 pm

1 stop6h 10m

Buffalo

Sun 10/12

6:00 am-10:46 am

1 stop4h 46m

$525

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Wed 10/8

6:14 am-3:31 pm

2 stops9h 17m

Buffalo

Mon 10/13

6:00 am-10:46 am

1 stop4h 46m

$530

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Thu 10/9

2:29 pm-6:52 pm

1 stop4h 23m

Buffalo

Sun 10/12

6:00 am-10:46 am

1 stop4h 46m

$551

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Thu 10/9

2:29 pm-6:52 pm

1 stop4h 23m

Buffalo

Mon 10/13

6:00 am-10:46 am

1 stop4h 46m

$551

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/8

Best time to book a flight from Florence to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Buffalo

What is the cheapest month to book a flight from Florence, South Carolina to Buffalo?

Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to Buffalo (average of $256). Flying from Florence, South Carolina to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florence to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Florence, South Carolina to Buffalo?

    Departing from Florence, South Carolina to Buffalo will take you 10h 49m. The distance from Florence, South Carolina to Buffalo is about 607 mi.

  • Can I find deals for flights from Florence to Buffalo that include hotel bookings?

    Yes. In addition to deals on Florence to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Buffalo.

  • Can I find deals for business class flights from Florence to Buffalo?

    Yes. Cheapflights offers flight deals from Florence to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to Buffalo (average of $256). Flying from Florence, South Carolina to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Florence to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to John F Kennedy Intl flights
Charlotte to Newark flights
Charlotte to LaGuardia flights
Charleston to Newark flights
Charleston to John F Kennedy Intl flights
Savannah to John F Kennedy Intl flights
Greenville to Newark flights
Charleston to LaGuardia flights
Greenville to John F Kennedy Intl flights
Greenville to LaGuardia flights
Savannah to Newark flights
Charlotte to Buffalo flights
Savannah to LaGuardia flights
Columbia to LaGuardia flights
Columbia to John F Kennedy Intl flights
Columbia to Newark flights
Myrtle Beach to LaGuardia flights
Myrtle Beach to Newark flights
Myrtle Beach to John F Kennedy Intl flights
Charlotte to Albany flights
Charlotte to Syracuse flights
Charlotte to Rochester flights
Myrtle Beach to White Plains flights
Charleston to White Plains flights
Greenville to Buffalo flights
Charleston to Islip flights
Charleston to Stewart flights
Myrtle Beach to Stewart flights
Hilton Head Island to Newark flights
Augusta to John F Kennedy Intl flights
Augusta to LaGuardia flights
Savannah to White Plains flights
Augusta to Newark flights
Greenville to Rochester flights
Greenville to Albany flights
Charleston to Buffalo flights
Hilton Head Island to John F Kennedy Intl flights
Hilton Head Island to LaGuardia flights
Greenville to White Plains flights
Columbia to Rochester flights
Greenville to Stewart flights
Charlotte to Islip flights
Savannah to Albany flights
Charleston to Albany flights
Savannah to Rochester flights
Savannah to Buffalo flights
Greenville to Syracuse flights
Charlotte to White Plains flights
Charlotte to Stewart flights
Columbia to Buffalo flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.