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$342+ Cheap flights from Florence, SC to Buffalo (FLO - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/1. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — BUF
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Cheap flight deals from Florence to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$503
(American Airlines)

One-way from

$342
(American Airlines)
Provider with most accurate pricing for Florence-Buffalo flight deals.
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Provider most trusted by Cheapflights users for Florence-Buffalo flights.
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From Florence to Buffalo
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One-way flight from Florence to Buffalo
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Find flight deals from Florence to Buffalo

Best flights from Florence to Buffalo
Discover carefully curated flight deals from Florence to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 28, 2025.

This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:13 amFLO - BUF
1 stop5h 34mAmerican Airlines
Sat 3/288:00 pmBUF - FLO
1 stop3h 38mAmerican Airlines
Deal found 10/25$503

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Florence to Buffalo that are best for you.

Fly from

Florence

Fly to

Buffalo

Route

Depart

Return

Price

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Wed 3/25

5:13 am-10:47 am

1 stop5h 34m

Buffalo

Sat 3/28

8:00 pm-11:38 pm

1 stop3h 38m

$503

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Sat 11/1

11:11 am-7:52 pm

2 stops8h 41m

$342

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/26

Compare providers for flights from Florence to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Florence to Buffalo in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Florence, South Carolina-Buffalo flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Florence, South Carolina-Buffalo flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Florence, South Carolina-Buffalo flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Florence to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Buffalo

What is the cheapest month to book a flight from Florence, South Carolina to Buffalo?

Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to Buffalo (average of $68). Flying from Florence, South Carolina to Buffalo in April is currently the most expensive (average of $177). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florence to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Florence, South Carolina to Buffalo?

    Departing from Florence, South Carolina to Buffalo will take you 5h 34m. The distance from Florence, South Carolina to Buffalo is about 607 mi.

  • Can I find deals for flights from Florence to Buffalo that include hotel bookings?

    Yes. In addition to deals on Florence to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Buffalo.

  • Can I find deals for business class flights from Florence to Buffalo?

    Yes. Cheapflights offers flight deals from Florence to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to Buffalo (average of $68). Flying from Florence, South Carolina to Buffalo in April is currently the most expensive (average of $177). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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