How long is the flight from Des Moines to Buffalo?

A quick flight from Des Moines to Buffalo can take about 3h 54m. American Airlines provides one of the quickest options available for as low as $351. Des Moines and Buffalo are separated by a distance of 768 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What are the cheapest airlines flying from Des Moines to Buffalo round-trip?

Delta, at $148, was found to be the cheapest airline from Des Moines to Buffalo.Alternate airlines to your destination round-trip include American Airlines and United Airlines. These flights start at 63% lower than the current average price 3 months from now.

What are the cheapest airlines to fly from Des Moines to Buffalo one-way?

The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $135. However, be on the lookout for offers from United Airlines and American Airlines, as they are both options that can get you from Des Moines to Buffalo for a low price.

In terms of precipitation, rainfall in Buffalo ranges from 2.5 - 4.0 inches per month. November is typically the wettest month, when rainfall can reach 4.0 in. February is typically the driest time to visit Buffalo when rainfall is around 2.5 in.

If weather is an important factor for your trip to Buffalo, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 24.8 F).

What are the most popular airlines that fly from Des Moines to Buffalo?

When booking a flight from Des Moines to Buffalo, you may want to consider flying on Delta, American Airlines or United Airlines as they are the most popular for this route.

What is the cheapest time of day to fly from DSM to BUF?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Buffalo as you normally would.

Most accurate provider : When it comes to deals on Des Moines-Buffalo flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Des Moines to Buffalo that include hotel bookings?

Yes. In addition to deals on Des Moines to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Buffalo?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Buffalo.

Can I find deals for business class flights from Des Moines to Buffalo?

Yes. Cheapflights offers flight deals from Des Moines to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$194+ Flights from Des Moines to Buffalo

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Cheap flight deals from Des Moines to Buffalo

Cheapest flights from Des Moines to Buffalo
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 17, 2025.

Wed 12/313:14 pmDSM - BUF

1 stop4h 40mUnited Airlines

Sun 1/46:30 amBUF - DSM

1 stop5h 19mUnited Airlines

Deal found 12/15

$438

Tue 12/303:14 pmDSM - BUF

1 stop4h 40mUnited Airlines

Sat 1/36:30 amBUF - DSM

1 stop5h 20mUnited Airlines

Deal found 12/15

$467

Wed 12/313:26 pmDSM - BUF

1 stop19h 36mAmerican Airlines

Sun 1/46:29 pmBUF - DSM

1 stop6h 01mAmerican Airlines

Deal found 12/16

$508

Best flights from Des Moines to Buffalo
Discover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 17, 2025.

Tue 1/65:01 pmDSM - BUF

1 stop5h 47mAmerican Airlines

Tue 1/136:32 pmBUF - DSM

1 stop5h 36mAmerican Airlines

Deal found 12/16

$311

Thu 1/2910:21 amDSM - BUF

1 stop5h 38mDelta

Thu 2/56:03 amBUF - DSM

1 stop4h 38mDelta

Deal found 12/14

$341

Thu 1/153:35 pmDSM - BUF

1 stop3h 54mUnited Airlines

Thu 1/225:23 pmBUF - DSM

1 stop5h 27mUnited Airlines

Deal found 12/16

$351

Tue 5/265:30 amDSM - BUF

1 stop3h 50mSouthwest

Mon 6/16:00 amBUF - DSM

1 stop6h 45mSouthwest

Deal found 12/16

$387

Thu 1/296:00 amDSM - BUF

2 stops8h 17mAmerican Airlines

Thu 2/55:27 pmBUF - DSM

1 stop5h 44mAmerican Airlines

Deal found 12/14

$347

Fri 1/306:24 amDSM - BUF

1 stop4h 21mDelta

Fri 2/62:56 pmBUF - DSM

1 stop5h 38mDelta

Deal found 12/16

$387

Thu 1/155:20 amDSM - BUF

2 stops7h 45mSouthwest

Thu 1/221:20 pmBUF - DSM

2 stops8h 50mSouthwest

Deal found 12/16

$389

Tue 5/2611:30 amDSM - BUF

2 stops10h 56mUnited Airlines

Mon 6/17:00 amBUF - DSM

1 stop4h 20mUnited Airlines

Deal found 12/16

$392

Last-minute flights from Des Moines to Buffalo
Discover last-minute flight deals from Des Moines to Buffalo. Data last updated December 17, 2025 and is based on user searches.

Tue 1/65:01 pmDSM - BUF

1 stop5h 47mAmerican Airlines

Tue 1/136:32 pmBUF - DSM

1 stop5h 36mAmerican Airlines

Deal found 12/16

$311

Fri 1/97:34 amDSM - BUF

1 stop5h 36mDelta

Sun 1/116:00 amBUF - DSM

1 stop5h 38mDelta

Deal found 12/15

$407

Fri 1/911:30 amDSM - BUF

2 stops10h 01mUnited Airlines

Sun 1/118:30 amBUF - DSM

1 stop7h 03mUnited Airlines

Deal found 12/15

$412

Thu 1/153:35 pmDSM - BUF

1 stop3h 54mUnited Airlines

Thu 1/225:23 pmBUF - DSM

1 stop5h 27mUnited Airlines

Deal found 12/16

$351

Thu 1/155:20 amDSM - BUF

2 stops7h 45mSouthwest

Thu 1/221:20 pmBUF - DSM

2 stops8h 50mSouthwest

Deal found 12/16

$389

Thu 1/2910:21 amDSM - BUF

1 stop5h 38mDelta

Thu 2/56:03 amBUF - DSM

1 stop4h 38mDelta

Deal found 12/14

$341

Thu 1/296:00 amDSM - BUF

2 stops8h 17mAmerican Airlines

Thu 2/55:27 pmBUF - DSM

1 stop5h 44mAmerican Airlines

Deal found 12/14

$347

One-way flights from Des Moines to Buffalo
Search for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated December 17, 2025.

Fri 1/305:16 pmDSM - BUF

1 stop5h 12mDelta

Deal found 12/16

$194

Sat 1/317:50 amDSM - BUF

2 stops10h 35mUnited Airlines

Deal found 12/17

$199

Tue 12/236:56 pmDSM - BUF

1 stop16h 32mAmerican Airlines

Deal found 12/14

$281

Mon 12/2210:29 amDSM - BUF

1 stop5h 43mDelta

Deal found 12/14

$289

Mon 12/225:30 amDSM - BUF

2 stops12h 50mSouthwest

Deal found 12/14

$294

Fri 1/301:35 pmDSM - BUF

2 stops22h 49mUnited Airlines

Deal found 12/16

$323

Tue 12/233:11 pmDSM - BUF

3 stops45h 01mMultiple Airlines

Deal found 12/14

$373

Mon 12/221:56 pmDSM - BUF

3 stops49h 53mMultiple Airlines

Deal found 12/14

$415

Find flight deals from Des Moines to Buffalo

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$311 (American Airlines)
One-way from	$194 (Delta)
Popular in	February
Cheapest in	October
Average price	$555

Provider with most accurate pricing for Des Moines-Buffalo flight deals.

Search Deals

Provider most trusted by Cheapflights users for Des Moines-Buffalo flights.

Search Deals

From Des Moines to Buffalo

Search Deals

One-way flight from Des Moines to Buffalo

Search Deals

Highest demand for flights based on searches. 23% potential increase in price ($125 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Tue 1/6

5:01 pm-11:48 pm

1 stop5h 47m

Buffalo

Tue 1/13

6:32 pm-11:08 pm

1 stop5h 36m

$311

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 1/29

10:21 am-4:59 pm

1 stop5h 38m

Buffalo

Thu 2/5

6:03 am-9:41 am

1 stop4h 38m

$341

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 1/29

6:00 am-3:17 pm

2 stops8h 17m

Buffalo

Thu 2/5

5:27 pm-10:11 pm

1 stop5h 44m

$347

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 1/15

3:35 pm-8:29 pm

1 stop3h 54m

Buffalo

Thu 1/22

5:23 pm-9:50 pm

1 stop5h 27m

$351

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Tue 5/26

5:30 am-10:20 am

1 stop3h 50m

Buffalo

Mon 6/1

6:00 am-11:45 am

1 stop6h 45m

$387

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 1/30

6:24 am-11:45 am

1 stop4h 21m

Buffalo

Fri 2/6

2:56 pm-7:34 pm

1 stop5h 38m

$387

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 1/15

5:20 am-2:05 pm

2 stops7h 45m

Buffalo

Thu 1/22

1:20 pm-9:10 pm

2 stops8h 50m

$389

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Tue 5/26

11:30 am-11:26 pm

2 stops10h 56m

Buffalo

Mon 6/1

7:00 am-10:20 am

1 stop4h 20m

$392

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sat 1/31

3:35 pm-8:29 pm

1 stop3h 54m

$194

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 1/30

5:16 pm-11:28 pm

1 stop5h 12m

$194

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 17 results

Compare providers for flights from Des Moines to Buffalo

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Priceline	Price Accuracy1 star	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Des Moines-Buffalo flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Buffalo

What is the cheapest month to book a flight from Des Moines to Buffalo?

Currently, June is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $100). Flying from Des Moines to Buffalo in January is currently the most expensive (average of $420). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Buffalo

Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Delta

7.9

Good

8,008 reviews

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

United Airlines

7.4

Good

9,092 reviews

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

American Airlines

7.2

Good

11,049 reviews

Delta

7.9

Good

8,008 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

How long is the flight from Des Moines to Buffalo?
A quick flight from Des Moines to Buffalo can take about 3h 54m. American Airlines provides one of the quickest options available for as low as $351. Des Moines and Buffalo are separated by a distance of 768 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines flying from Des Moines to Buffalo round-trip?
Delta, at $148, was found to be the cheapest airline from Des Moines to Buffalo.Alternate airlines to your destination round-trip include American Airlines and United Airlines. These flights start at 63% lower than the current average price 3 months from now.
What are the cheapest airlines to fly from Des Moines to Buffalo one-way?
The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $135. However, be on the lookout for offers from United Airlines and American Airlines, as they are both options that can get you from Des Moines to Buffalo for a low price.
Can I find deals for flights from Des Moines to Buffalo that include hotel bookings?
Yes. In addition to deals on Des Moines to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Buffalo?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Buffalo.
Can I find deals for business class flights from Des Moines to Buffalo?
Yes. Cheapflights offers flight deals from Des Moines to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Buffalo?
Currently, June is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $100). Flying from Des Moines to Buffalo in January is currently the most expensive (average of $420). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Des Moines to Buffalo

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$148	Average$332	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$238	Average$351	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$360	Average$460	FlexibilityNo cancel fee	On-time69%

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$194+ Cheap flights from Des Moines to Buffalo (DSM - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/31. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Buffalo with Cheapflights

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Cheap flight deals from Des Moines to Buffalo

Cheapest flights from Des Moines to BuffaloExplore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 17, 2025.

Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 17, 2025.

Find flight deals from Des Moines to Buffalo

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

Compare providers for flights from Des Moines to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in December.

Best time to book a flight from Des Moines to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Buffalo

What is the cheapest month to book a flight from Des Moines to Buffalo?

Reviews of airlines servicing Buffalo

Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Des Moines to Buffalo?

What are the cheapest airlines flying from Des Moines to Buffalo round-trip?

What are the cheapest airlines to fly from Des Moines to Buffalo one-way?

Can I find deals for flights from Des Moines to Buffalo that include hotel bookings?

How can I find direct flights from Des Moines to Buffalo?

Can I find deals for business class flights from Des Moines to Buffalo?

What is the cheapest month to book a flight from Des Moines to Buffalo?

Traveling to a place near Buffalo?

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Alternative routes for Des Moines to Buffalo

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Top 3 airlines flying from Des Moines to Buffalo

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Cheapest flights from Des Moines to Buffalo
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 17, 2025.