$183+ Cheap flights from Des Moines to Buffalo (DSM - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
May 15 — May 221
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to BuffaloExplore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2026.
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2026.
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:34 pm
DSM
- BUF
1 stop5h 28m
Delta
Wed 6/245:12 pm
BUF
- DSM
1 stop6h 19m
Delta
Deal found 4/12![Delta logo]()
$335
This United Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/91:35 pm
DSM
- BUF
1 stop8h 30m
United Airlines
Tue 5/127:00 am
BUF
- DSM
1 stop4h 37m
United Airlines
Deal found 4/11![United Airlines logo]()
$346
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2711:57 am
DSM
- BUF
1 stop5h 47m
Delta
Mon 6/16:15 am
BUF
- DSM
1 stop8h 22m
Delta
Deal found 4/13![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/44:40 pm
DSM
- BUF
2 stops6h 30m
Southwest
Tue 9/16:25 pm
BUF
- DSM
1 stop4h 30m
Southwest
Deal found 4/10![Southwest logo]()
$360
This Southwest deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:35 am
DSM
- BUF
2 stops7h 40m
Southwest
Tue 5/121:10 pm
BUF
- DSM
2 stops10h 00m
Southwest
Deal found 4/11![Southwest logo]()
$365
This Southwest deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/285:40 am
DSM
- BUF
1 stop4h 05m
Southwest
Wed 9/26:25 pm
BUF
- DSM
1 stop4h 30m
Southwest
Deal found 4/11![Southwest logo]()
$371
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:56 pm
DSM
- BUF
1 stop5h 03m
Delta
Thu 6/46:15 am
BUF
- DSM
1 stop8h 22m
Delta
Deal found 4/13![Delta logo]()
$375
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/301:48 pm
DSM
- BUF
1 stop7h 09m
American Airlines
Sat 6/610:01 am
BUF
- DSM
1 stop4h 19m
American Airlines
Deal found 4/14![American Airlines logo]()
$377
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:00 am
DSM
- BUF
2 stops7h 33m
American Airlines
Mon 6/17:31 pm
BUF
- DSM
1 stop5h 46m
American Airlines
Deal found 4/13![American Airlines logo]()
$380
This United Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2411:23 am
DSM
- BUF
1 stop4h 23m
United Airlines
Wed 7/297:00 am
BUF
- DSM
1 stop4h 27m
United Airlines
Deal found 4/11![United Airlines logo]()
$391
Best flights from Des Moines to BuffaloDiscover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 15, 2026.
Discover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 15, 2026.
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:34 pm
DSM
- BUF
1 stop5h 28m
Delta
Wed 6/245:12 pm
BUF
- DSM
1 stop6h 19m
Delta
Deal found 4/12![Delta logo]()
$335
This United Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/98:00 am
DSM
- BUF
1 stop4h 18m
United Airlines
Tue 5/1211:02 am
BUF
- DSM
2 stops10h 14m
United Airlines
Deal found 4/11![United Airlines logo]()
$351
This American Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/41:37 pm
DSM
- BUF
1 stop7h 59m
American Airlines
Tue 9/111:54 am
BUF
- DSM
1 stop6h 31m
American Airlines
Deal found 4/10![American Airlines logo]()
$355
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/44:40 pm
DSM
- BUF
2 stops6h 30m
Southwest
Tue 9/16:25 pm
BUF
- DSM
1 stop4h 30m
Southwest
Deal found 4/10![Southwest logo]()
$360
This Southwest deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/285:40 am
DSM
- BUF
1 stop4h 05m
Southwest
Wed 9/26:25 pm
BUF
- DSM
1 stop4h 30m
Southwest
Deal found 4/11![Southwest logo]()
$371
This United Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2411:23 am
DSM
- BUF
1 stop4h 23m
United Airlines
Wed 7/297:00 am
BUF
- DSM
1 stop4h 27m
United Airlines
Deal found 4/11![United Airlines logo]()
$391
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:35 am
DSM
- BUF
2 stops7h 40m
Southwest
Sat 6/66:55 pm
BUF
- DSM
1 stop4h 55m
Southwest
Deal found 4/14![Southwest logo]()
$380
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:02 am
DSM
- BUF
1 stop5h 52m
United Airlines
Wed 5/137:00 am
BUF
- DSM
1 stop4h 37m
United Airlines
Deal found 4/10![United Airlines logo]()
$415
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:25 am
DSM
- BUF
2 stops10h 15m
Southwest
Thu 6/47:55 pm
BUF
- DSM
1 stop4h 35m
Southwest
Deal found 4/13![Southwest logo]()
$394
Last-minute flights from Des Moines to BuffaloDiscover last-minute flight deals from Des Moines to Buffalo. Data last updated April 15, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Buffalo. Data last updated April 15, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/91:35 pm
DSM
- BUF
1 stop8h 30m
United Airlines
Tue 5/127:00 am
BUF
- DSM
1 stop4h 37m
United Airlines
Deal found 4/11![United Airlines logo]()
$346
This Southwest deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:35 am
DSM
- BUF
2 stops7h 40m
Southwest
Tue 5/121:10 pm
BUF
- DSM
2 stops10h 00m
Southwest
Deal found 4/11![Southwest logo]()
$365
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:40 am
DSM
- BUF
1 stop4h 14m
United Airlines
Wed 5/137:00 am
BUF
- DSM
1 stop4h 37m
United Airlines
Deal found 4/12![United Airlines logo]()
$415
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2711:57 am
DSM
- BUF
1 stop5h 47m
Delta
Mon 6/16:15 am
BUF
- DSM
1 stop8h 22m
Delta
Deal found 4/13![Delta logo]()
$355
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:00 am
DSM
- BUF
2 stops7h 33m
American Airlines
Mon 6/17:31 pm
BUF
- DSM
1 stop5h 46m
American Airlines
Deal found 4/13![American Airlines logo]()
$380
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:56 pm
DSM
- BUF
1 stop5h 03m
Delta
Thu 6/46:15 am
BUF
- DSM
1 stop8h 22m
Delta
Deal found 4/13![Delta logo]()
$375
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:25 am
DSM
- BUF
2 stops10h 15m
Southwest
Thu 6/47:55 pm
BUF
- DSM
1 stop4h 35m
Southwest
Deal found 4/13![Southwest logo]()
$394
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/301:48 pm
DSM
- BUF
1 stop7h 09m
American Airlines
Sat 6/610:01 am
BUF
- DSM
1 stop4h 19m
American Airlines
Deal found 4/14![American Airlines logo]()
$377
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:35 am
DSM
- BUF
2 stops7h 40m
Southwest
Sat 6/612:35 pm
BUF
- DSM
2 stops10h 20m
Southwest
Deal found 4/14![Southwest logo]()
$421
One-way flights from Des Moines to BuffaloSearch for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated April 15, 2026.
Search for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated April 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/253:57 pm
DSM
- BUF
2 stops44h 57m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$183
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/251:05 pm
DSM
- BUF
1 stop6h 58m
United Airlines
Deal found 4/13![United Airlines logo]()
$204
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:00 am
DSM
- BUF
2 stops12h 03m
United Airlines
Deal found 4/14![United Airlines logo]()
$228
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/256:50 am
DSM
- BUF
2 stops10h 25m
Southwest
Deal found 4/13![Southwest logo]()
$313
Find flight deals from Des Moines to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $335 (Delta) |
One-way from | $183 (Kiwi.com) |
Popular in | March |
Cheapest in | June |
Average price | $364 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 15, 2026.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Wed 6/17
5:34 pm-12:02 am
1 stop5h 28m
Buffalo
Wed 6/24
5:12 pm-10:31 pm
1 stop6h 19m
$335
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Sat 5/9
8:00 am-1:18 pm
1 stop4h 18m
Buffalo
Tue 5/12
11:02 am-8:16 pm
2 stops10h 14m
$351
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Thu 6/4
1:37 pm-10:36 pm
1 stop7h 59m
Buffalo
Tue 9/1
11:54 am-5:25 pm
1 stop6h 31m
$355
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Thu 6/4
4:40 pm-12:10 am
2 stops6h 30m
Buffalo
Tue 9/1
6:25 pm-9:55 pm
1 stop4h 30m
$360
Quickest round-trip
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Fri 8/28
5:40 am-10:45 am
1 stop4h 05m
Buffalo
Wed 9/2
6:25 pm-9:55 pm
1 stop4h 30m
$371
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Sat 5/30
5:35 am-2:15 pm
2 stops7h 40m
Buffalo
Sat 6/6
6:55 pm-10:50 pm
1 stop4h 55m
$380
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Fri 7/24
11:23 am-4:46 pm
1 stop4h 23m
Buffalo
Wed 7/29
7:00 am-10:27 am
1 stop4h 27m
$391
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Thu 5/28
5:25 am-4:40 pm
2 stops10h 15m
Buffalo
Thu 6/4
7:55 pm-11:30 pm
1 stop4h 35m
$394
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Tue 5/12
10:02 am-4:54 pm
1 stop5h 52m
Buffalo
Wed 5/13
7:00 am-10:37 am
1 stop4h 37m
$415
Cheapest one-way
Quickest one-way
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Mon 5/25
6:02 am-12:17 pm
1 stop5h 15m
$204
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
DSM-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Buffalo
What is the cheapest month to book a flight from Des Moines to Buffalo?
Currently, June is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $100). Flying from Des Moines to Buffalo in November is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Buffalo?
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated April 15, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Overall
7.9
Comfort
7.9
Entertainment
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Food
7.2
Overall
7.9
Comfort
7.9
Entertainment
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Food
7.2
Overall
7.9
Comfort
7.9
Entertainment
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Food
7.2
Overall
7.9
Comfort
7.9
Entertainment
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 15, 2026.
Complete your trip
Complete your trip to Buffalo by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to Buffalo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Buffalo flights
Browse other Des Moines and Buffalo flight options. Last updated on April 15, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on April 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Buffalo
Discover the top 3 airlines that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$148 | Average$332 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$238 | Average$334 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$341 | Average$441 | FlexibilityNo cancel fee | On-time69% |