$269+ Cheap flights from Des Moines to Buffalo (DSM - BUF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/3. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Nov 5 — Nov 121
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Buffalo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Buffalo
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Cheapest flights from Des Moines to BuffaloExplore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 6, 2026.
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 6, 2026.
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/33:30 pm -
1 stop4h 20m
Tue 11/108:05 am -
1 stop4h 20m
Deal found 10/6![Southwest logo]()
$269
This Southwest deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:25 am -
1 stop4h 00m
Tue 11/106:55 pm -
1 stop4h 10m
Deal found 10/4![Southwest logo]()
$270
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/39:55 am -
2 stops8h 09m
Tue 11/105:58 pm -
1 stop4h 57m
Deal found 10/6![United Airlines logo]()
$274
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:23 am -
2 stops9h 02m
Tue 11/104:16 pm -
2 stops9h 02m
Deal found 10/6![American Airlines logo]()
$280
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:23 am -
2 stops9h 03m
Sat 11/147:57 am -
1 stop6h 31m
Deal found 10/1![American Airlines logo]()
$330
This United Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:27 pm -
1 stop8h 06m
Fri 11/135:58 pm -
1 stop6h 01m
Deal found 10/1![United Airlines logo]()
$350
This American Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:23 am -
2 stops9h 03m
Fri 11/134:16 pm -
2 stops9h 10m
Deal found 10/2![American Airlines logo]()
$360
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:50 pm -
1 stop5h 09m
Tue 10/276:15 am -
1 stop4h 27m
Deal found 10/6![Delta logo]()
$393
This Southwest deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:30 pm -
1 stop4h 25m
Sat 11/144:35 pm -
1 stop4h 10m
Deal found 10/2![Southwest logo]()
$397
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:02 am -
1 stop7h 23m
Tue 10/275:40 pm -
2 stops7h 34m
Deal found 10/6![American Airlines logo]()
$398
This Southwest deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
1 stop3h 40m
Fri 11/1312:40 pm -
2 stops11h 25m
Deal found 10/2![Southwest logo]()
$402
Best flights from Des Moines to BuffaloDiscover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 6, 2026.
Discover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 6, 2026.
This Southwest deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:25 am -
1 stop4h 00m
Tue 11/106:55 pm -
1 stop4h 10m
Deal found 10/4![Southwest logo]()
$270
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/39:55 am -
2 stops8h 09m
Tue 11/105:58 pm -
1 stop4h 57m
Deal found 10/6![United Airlines logo]()
$274
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:50 pm -
1 stop5h 09m
Tue 10/276:15 am -
1 stop4h 27m
Deal found 10/6![Delta logo]()
$393
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:02 am -
1 stop7h 23m
Tue 10/275:40 pm -
2 stops7h 34m
Deal found 10/6![American Airlines logo]()
$398
This Southwest deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:30 pm -
1 stop4h 25m
Sat 11/144:35 pm -
1 stop4h 10m
Deal found 10/2![Southwest logo]()
$397
This Southwest deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
1 stop3h 40m
Fri 11/137:10 pm -
1 stop4h 55m
Deal found 10/2![Southwest logo]()
$397
Last-minute flights from Des Moines to BuffaloDiscover last-minute flight deals from Des Moines to Buffalo. Data last updated October 6, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Buffalo. Data last updated October 6, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:50 pm -
1 stop5h 09m
Tue 10/276:15 am -
1 stop4h 27m
Deal found 10/6![Delta logo]()
$393
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:02 am -
1 stop7h 23m
Tue 10/275:40 pm -
2 stops7h 34m
Deal found 10/6![American Airlines logo]()
$398
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/33:30 pm -
1 stop4h 20m
Tue 11/108:05 am -
1 stop4h 20m
Deal found 10/6![Southwest logo]()
$269
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/39:55 am -
2 stops8h 09m
Tue 11/105:58 pm -
1 stop4h 57m
Deal found 10/6![United Airlines logo]()
$274
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:23 am -
2 stops9h 02m
Tue 11/104:16 pm -
2 stops9h 02m
Deal found 10/6![American Airlines logo]()
$280
This Southwest deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:25 am -
1 stop4h 00m
Tue 11/106:55 pm -
1 stop4h 10m
Deal found 10/4![Southwest logo]()
$270
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:23 am -
2 stops9h 03m
Sat 11/147:57 am -
1 stop6h 31m
Deal found 10/1![American Airlines logo]()
$330
This United Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:27 pm -
1 stop8h 06m
Fri 11/135:58 pm -
1 stop6h 01m
Deal found 10/1![United Airlines logo]()
$350
This American Airlines deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:23 am -
2 stops9h 03m
Fri 11/134:16 pm -
2 stops9h 10m
Deal found 10/2![American Airlines logo]()
$360
This Southwest deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:30 pm -
1 stop4h 25m
Sat 11/144:35 pm -
1 stop4h 10m
Deal found 10/2![Southwest logo]()
$397
This Southwest deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
1 stop3h 40m
Fri 11/1312:40 pm -
2 stops11h 25m
Deal found 10/2![Southwest logo]()
$402
One-way flights from Des Moines to BuffaloSearch for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated October 6, 2026.
Search for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated October 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:57 pm -
2 stops16h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![Multiple Airlines logo]()
$444
This Southwest deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:10 am -
1 stop4h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![Southwest logo]()
$509
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:22 pm -
3 stops22h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![United Airlines logo]()
$754
Find flight deals from Des Moines to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $269 (Southwest) |
Popular in | March |
Cheapest in | August |
Average price | $452 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 6, 2026.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Thu 11/5
5:25 am-10:25 am
1 stop4h 00m
Buffalo
Tue 11/10
6:55 pm-10:05 pm
1 stop4h 10m
$270
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Tue 11/3
9:55 am-7:04 pm
2 stops8h 09m
Buffalo
Tue 11/10
5:58 pm-9:55 pm
1 stop4h 57m
$274
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Sun 10/25
5:50 pm-11:59 pm
1 stop5h 09m
Buffalo
Tue 10/27
6:15 am-9:42 am
1 stop4h 27m
$393
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Wed 11/11
3:30 pm-8:55 pm
1 stop4h 25m
Buffalo
Sat 11/14
4:35 pm-7:45 pm
1 stop4h 10m
$397
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Wed 11/11
6:00 am-10:40 am
1 stop3h 40m
Buffalo
Fri 11/13
7:10 pm-11:05 pm
1 stop4h 55m
$397
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Sun 10/25
6:02 am-2:25 pm
1 stop7h 23m
Buffalo
Tue 10/27
5:40 pm-12:14 am
2 stops7h 34m
$398
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Fri 10/9
7:57 pm-12:59 pm
2 stops16h 02m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$444
Quickest round-trip
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Fri 10/9
5:10 am-10:25 am
1 stop4h 15m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$509
Des MoinesBuffalo
DSM Des Moines - BUF Buffalo
DSMBUF
Des Moines
Fri 10/9
5:22 pm-4:43 pm
3 stops22h 21m
Buffalo
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$754
Sorted by cheapest first
Compare providers for flights from Des Moines to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
DSM-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated October 6, 2026.
Read reviews from past customers who have flown American Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.4
Food
6.4
Crew
7.9
Overall
7.0
Comfort
7.2
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2023
DFW - JFK
Boarding
7.4
Food
6.4
Crew
7.9
Overall
7.0
Comfort
7.2
Entertainment
6.8
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2023
DFW - JFK
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsCheektowaga
Lockport
Amherst
Williamsville
Orchard Park
Eden
Bowmansville
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 6, 2026.
Complete your trip
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Des Moines and Buffalo flights
Browse other Des Moines and Buffalo flight options. Last updated on October 6, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on October 6, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Des Moines to Buffalo
Discover the top airline that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$250 | Average$406 | FlexibilityNo cancel fee | On-time71% |