Buffalo

$188+ Cheap flights from Des Moines to Buffalo (DSM - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/3. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
May 28 — Jun 41
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Cheap flight deals from Des Moines to Buffalo

Cheapest flights from Des Moines to Buffalo
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.

This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/61:05 pm
DSM
-
BUF
1 stop6h 58m
United Airlines
Tue 6/97:00 am
BUF
-
DSM
1 stop4h 27m
United Airlines
Deal found 4/23$373
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/51:37 pm
DSM
-
BUF
1 stop7h 59m
American Airlines
Fri 6/121:49 pm
BUF
-
DSM
1 stop7h 54m
American Airlines
Deal found 4/23$382
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/251:37 pm
DSM
-
BUF
1 stop7h 59m
American Airlines
Fri 7/38:02 am
BUF
-
DSM
1 stop6h 07m
American Airlines
Deal found 4/25$391
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/251:05 pm
DSM
-
BUF
1 stop6h 36m
United Airlines
Thu 7/27:00 am
BUF
-
DSM
1 stop4h 27m
United Airlines
Deal found 4/28$407
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/148:56 am
DSM
-
BUF
1 stop4h 25m
American Airlines
Tue 5/195:32 pm
BUF
-
DSM
1 stop5h 21m
American Airlines
Deal found 4/24$411
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/257:13 pm
DSM
-
BUF
1 stop4h 25m
American Airlines
Thu 7/26:00 am
BUF
-
DSM
2 stops7h 56m
American Airlines
Deal found 4/28$412
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/276:33 pm
DSM
-
BUF
1 stop4h 31m
American Airlines
Sun 8/26:27 am
BUF
-
DSM
1 stop7h 38m
American Airlines
Deal found 4/27$415
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:40 am
DSM
-
BUF
2 stops10h 10m
Southwest
Thu 9/171:40 pm
BUF
-
DSM
2 stops9h 30m
Southwest
Deal found 4/27$417
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/211:23 am
DSM
-
BUF
1 stop4h 23m
United Airlines
Wed 6/310:34 am
BUF
-
DSM
2 stops12h 06m
United Airlines
Deal found 4/27$420
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/25:10 am
DSM
-
BUF
2 stops8h 15m
Southwest
Sat 8/87:50 am
BUF
-
DSM
1 stop4h 40m
Southwest
Deal found 4/25$422
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/143:20 pm
DSM
-
BUF
1 stop4h 41m
United Airlines
Tue 5/196:04 am
BUF
-
DSM
2 stops9h 20m
United Airlines
Deal found 4/24$426

Find flight deals from Des Moines to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$373
(United Airlines)

One-way from

$188
(American Airlines)

Popular in

March

Cheapest in

June

Average price

$364
Provider with most accurate pricing for Des Moines-Buffalo flight deals.
Provider most trusted by Cheapflights users for Des Moines-Buffalo flights.
From Des Moines to Buffalo
One-way flight from Des Moines to Buffalo
Highest demand for flights based on searches. 20% potential increase in price ($96 potential increase over avg. RT price).
Cheapest flight prices on average. 9% potential price decrease ($32 potential savings vs. average RT price).
Average for round-trip flights in April 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sat 6/6

1:05 pm-9:03 pm

1 stop6h 58m

Buffalo

Tue 6/9

7:00 am-10:27 am

1 stop4h 27m

$373

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 6/5

1:37 pm-10:36 pm

1 stop7h 59m

Buffalo

Fri 6/12

1:49 pm-8:43 pm

1 stop7h 54m

$382

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 6/25

1:05 pm-8:41 pm

1 stop6h 36m

Buffalo

Thu 7/2

7:00 am-12:30 pm

1 stop6h 30m

$407

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Mon 7/27

1:41 pm-10:52 pm

1 stop8h 11m

Buffalo

Sun 8/2

6:27 am-1:05 pm

1 stop7h 38m

$415

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Tue 6/2

11:23 am-4:46 pm

1 stop4h 23m

Buffalo

Wed 6/3

9:00 am-4:15 pm

1 stop8h 15m

$415

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 6/25

4:40 pm-12:10 am

2 stops6h 30m

Buffalo

Thu 7/2

2:50 pm-11:30 pm

2 stops9h 40m

$427
Cheapest one-way
Quickest one-way

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 7/3

6:33 pm-12:04 am

1 stop4h 31m

$188

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 7/3

4:40 pm-10:39 am

2 stops40h 59m

$191

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/27

Sorted by cheapest first

Compare providers for flights from Des Moines to Buffalo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Buffalo

What is the cheapest month to book a flight from Des Moines to Buffalo?

Currently, June is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $148). Flying from Des Moines to Buffalo in March is currently the most expensive (average of $736). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Buffalo?

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated April 28, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Boarding

8.1

Entertainment

7.8

Crew

8.5

Comfort

7.9

Overall

7.9

Food

7.2

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Boarding

8.1

Entertainment

7.8

Crew

8.5

Comfort

7.9

Overall

7.9

Food

7.2

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Boarding

8.1

Entertainment

7.8

Crew

8.5

Comfort

7.9

Overall

7.9

Food

7.2

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Boarding

8.1

Entertainment

7.8

Crew

8.5

Comfort

7.9

Overall

7.9

Food

7.2

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How long is the flight from Des Moines to Buffalo?

    A quick flight from Des Moines to Buffalo can take about 6h 58m. United Airlines provides one of the quickest options available for as low as $373. Des Moines and Buffalo are separated by a distance of 768 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Buffalo round-trip?

    Delta, at $148, was found to be the cheapest airline from Des Moines to Buffalo.Alternate airlines to your destination round-trip include American Airlines and United Airlines. These flights start at 61% lower than the current average price 3 months from now.

  • Can I find deals for flights from Des Moines to Buffalo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Buffalo.

  • Can I find deals for business class flights from Des Moines to Buffalo?

    Yes. Cheapflights offers flight deals from Des Moines to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Buffalo?

    Currently, June is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $148). Flying from Des Moines to Buffalo in March is currently the most expensive (average of $736). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca

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Top 3 airlines flying from Des Moines to Buffalo

Discover the top 3 airlines that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$148Average$332FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$238Average$334FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$341Average$441FlexibilityNo cancel feeOn-time69%

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