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$149+ Cheap flights from Des Moines to Buffalo (DSM - BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/8. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Des Moines to Buffalo

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$313
(Delta)

One-way from

$149
(American Airlines)

Popular in

December

Cheapest in

November

Average price

$334
From Des Moines to Buffalo
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One-way flight from Des Moines to Buffalo
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Highest demand for flights based on searches. 15% potential increase in price ($75 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($29 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Buffalo

Cheapest flights from Des Moines to Buffalo
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:20 amDSM - BUF
1 stop5h 27mDelta
Thu 11/66:20 amBUF - DSM
1 stop4h 00mDelta
Deal found 9/14$313
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/236:22 pmDSM - BUF
1 stop4h 53mAmerican Airlines
Mon 10/273:34 pmBUF - DSM
1 stop7h 54mAmerican Airlines
Deal found 9/15$334
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/265:47 pmDSM - BUF
1 stop4h 10mDelta
Tue 12/306:10 amBUF - DSM
1 stop4h 38mDelta
Deal found 9/15$342
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/217:00 amDSM - BUF
1 stop7h 13mAmerican Airlines
Tue 11/255:43 pmBUF - DSM
1 stop7h 12mAmerican Airlines
Deal found 9/17$352
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/106:22 pmDSM - BUF
1 stop4h 53mAmerican Airlines
Mon 10/135:27 pmBUF - DSM
1 stop6h 56mAmerican Airlines
Deal found 9/17$355
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/56:15 amDSM - BUF
2 stops10h 20mSouthwest
Mon 12/812:10 pmBUF - DSM
2 stops10h 25mSouthwest
Deal found 9/14$366
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/3011:17 amDSM - BUF
1 stop5h 46mDelta
Tue 10/146:00 amBUF - DSM
1 stop5h 05mDelta
Deal found 9/16$372
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/236:35 amDSM - BUF
1 stop9h 00mSouthwest
Mon 10/275:15 pmBUF - DSM
2 stops7h 15mSouthwest
Deal found 9/15$375
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:00 amDSM - BUF
1 stop7h 05mAmerican Airlines
Tue 10/146:07 amBUF - DSM
2 stops8h 11mAmerican Airlines
Deal found 9/15$377
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/266:50 pmDSM - BUF
2 stops12h 05mSouthwest
Mon 12/13:10 pmBUF - DSM
2 stops9h 55mSouthwest
Deal found 9/15$388
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/512:57 pmDSM - BUF
2 stops8h 56mAmerican Airlines
Mon 12/85:03 amBUF - DSM
1 stop8h 20mAmerican Airlines
Deal found 9/14$391

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

Fly from

Des Moines

Fly to

Buffalo

Route

Depart

Return

Price

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 10/30

7:20 am-1:47 pm

1 stop5h 27m

Buffalo

Thu 11/6

6:20 am-9:20 am

1 stop4h 00m

$313

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sat 12/6

4:05 pm-12:07 am

1 stop7h 02m

Buffalo

Mon 12/8

5:03 am-12:23 pm

1 stop8h 20m

$313

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 12/5

5:04 pm-11:24 pm

1 stop5h 20m

Buffalo

Mon 12/8

5:03 am-12:23 pm

1 stop8h 20m

$334

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 10/23

6:22 pm-12:15 am

1 stop4h 53m

Buffalo

Mon 10/27

3:34 pm-10:28 pm

1 stop7h 54m

$334

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 11/21

7:00 am-3:13 pm

1 stop7h 13m

Buffalo

Tue 11/25

5:43 pm-11:55 pm

1 stop7h 12m

$352

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 10/10

6:22 pm-12:15 am

1 stop4h 53m

Buffalo

Mon 10/13

5:27 pm-11:23 pm

1 stop6h 56m

$355

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 12/5

6:15 am-5:35 pm

2 stops10h 20m

Buffalo

Mon 12/8

12:10 pm-9:35 pm

2 stops10h 25m

$366

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sat 12/6

5:25 am-7:55 pm

2 stops13h 30m

Buffalo

Mon 12/8

12:10 pm-9:35 pm

2 stops10h 25m

$372

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Tue 9/30

7:15 am-1:49 pm

1 stop5h 34m

Buffalo

Tue 10/14

6:00 am-10:05 am

1 stop5h 05m

$372

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 10/23

6:35 am-4:35 pm

1 stop9h 00m

Buffalo

Mon 10/27

5:15 pm-11:30 pm

2 stops7h 15m

$375

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 16 results
1
2

Best time to book a flight from Des Moines to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Buffalo

What is the cheapest month to book a flight from Des Moines to Buffalo?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $256). Flying from Des Moines to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated September 17, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Buffalo?

    A quick flight from Des Moines to Buffalo can take about 5h 27m. Delta provides one of the quickest options available for as low as $313. Des Moines and Buffalo are separated by a distance of 768 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Buffalo round-trip?

    Delta, at $216, was found to be the cheapest airline from Des Moines to Buffalo.Alternate airlines to your destination round-trip include American Airlines and United Airlines. These flights start at 48% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Buffalo one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $159. However, be on the lookout for offers from United Airlines and American Airlines, as they are both options that can get you from Des Moines to Buffalo for a low price.

  • Can I find deals for flights from Des Moines to Buffalo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Buffalo.

  • Can I find deals for business class flights from Des Moines to Buffalo?

    Yes. Cheapflights offers flight deals from Des Moines to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $256). Flying from Des Moines to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Lockport
Orchard Park
Batavia
Williamsville
Eden
Amherst
West Seneca

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Top 3 airlines flying from Des Moines to Buffalo

Discover the top 3 airlines that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$332FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$238Average$351FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$341Average$441FlexibilityNo cancel feeOn-time69%

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