$188+ Cheap flights from Des Moines to Buffalo (DSM - BUF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/3. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BUF
May 28 — Jun 41
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Buffalo with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Buffalo
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Best
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Cheapest flights from Des Moines to BuffaloExplore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.
Explore the most affordable flight options available from Des Moines to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/61:05 pm
DSM
- BUF
1 stop6h 58m
United Airlines
Tue 6/97:00 am
BUF
- DSM
1 stop4h 27m
United Airlines
Deal found 4/23![United Airlines logo]()
$373
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/51:37 pm
DSM
- BUF
1 stop7h 59m
American Airlines
Fri 6/121:49 pm
BUF
- DSM
1 stop7h 54m
American Airlines
Deal found 4/23![American Airlines logo]()
$382
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/251:37 pm
DSM
- BUF
1 stop7h 59m
American Airlines
Fri 7/38:02 am
BUF
- DSM
1 stop6h 07m
American Airlines
Deal found 4/25![American Airlines logo]()
$391
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/251:05 pm
DSM
- BUF
1 stop6h 36m
United Airlines
Thu 7/27:00 am
BUF
- DSM
1 stop4h 27m
United Airlines
Deal found 4/28![United Airlines logo]()
$407
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/148:56 am
DSM
- BUF
1 stop4h 25m
American Airlines
Tue 5/195:32 pm
BUF
- DSM
1 stop5h 21m
American Airlines
Deal found 4/24![American Airlines logo]()
$411
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/257:13 pm
DSM
- BUF
1 stop4h 25m
American Airlines
Thu 7/26:00 am
BUF
- DSM
2 stops7h 56m
American Airlines
Deal found 4/28![American Airlines logo]()
$412
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/276:33 pm
DSM
- BUF
1 stop4h 31m
American Airlines
Sun 8/26:27 am
BUF
- DSM
1 stop7h 38m
American Airlines
Deal found 4/27![American Airlines logo]()
$415
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:40 am
DSM
- BUF
2 stops10h 10m
Southwest
Thu 9/171:40 pm
BUF
- DSM
2 stops9h 30m
Southwest
Deal found 4/27![Southwest logo]()
$417
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/211:23 am
DSM
- BUF
1 stop4h 23m
United Airlines
Wed 6/310:34 am
BUF
- DSM
2 stops12h 06m
United Airlines
Deal found 4/27![United Airlines logo]()
$420
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/25:10 am
DSM
- BUF
2 stops8h 15m
Southwest
Sat 8/87:50 am
BUF
- DSM
1 stop4h 40m
Southwest
Deal found 4/25![Southwest logo]()
$422
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/143:20 pm
DSM
- BUF
1 stop4h 41m
United Airlines
Tue 5/196:04 am
BUF
- DSM
2 stops9h 20m
United Airlines
Deal found 4/24![United Airlines logo]()
$426
Best flights from Des Moines to BuffaloDiscover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 28, 2026.
Discover carefully curated flight deals from Des Moines to Buffalo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 28, 2026.
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/61:05 pm
DSM
- BUF
1 stop6h 58m
United Airlines
Tue 6/97:00 am
BUF
- DSM
1 stop4h 27m
United Airlines
Deal found 4/23![United Airlines logo]()
$373
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/51:37 pm
DSM
- BUF
1 stop7h 59m
American Airlines
Fri 6/121:49 pm
BUF
- DSM
1 stop7h 54m
American Airlines
Deal found 4/23![American Airlines logo]()
$382
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/254:40 pm
DSM
- BUF
2 stops6h 30m
Southwest
Thu 7/22:50 pm
BUF
- DSM
2 stops9h 40m
Southwest
Deal found 4/28![Southwest logo]()
$427
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/251:05 pm
DSM
- BUF
1 stop6h 36m
United Airlines
Thu 7/27:00 am
BUF
- DSM
1 stop6h 30m
United Airlines
Deal found 4/27![United Airlines logo]()
$407
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/271:41 pm
DSM
- BUF
1 stop8h 11m
American Airlines
Sun 8/26:27 am
BUF
- DSM
1 stop7h 38m
American Airlines
Deal found 4/26![American Airlines logo]()
$415
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/211:23 am
DSM
- BUF
1 stop4h 23m
United Airlines
Wed 6/39:00 am
BUF
- DSM
1 stop8h 15m
United Airlines
Deal found 4/27![United Airlines logo]()
$415
Last-minute flights from Des Moines to BuffaloDiscover last-minute flight deals from Des Moines to Buffalo. Data last updated April 28, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Buffalo. Data last updated April 28, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/275:25 am
DSM
- BUF
1 stop3h 50m
Southwest
Thu 4/308:00 pm
BUF
- DSM
1 stop4h 05m
Southwest
Deal found 4/26![Southwest logo]()
$757
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:25 am
DSM
- BUF
1 stop3h 50m
Southwest
Mon 5/118:00 pm
BUF
- DSM
1 stop4h 05m
Southwest
Deal found 4/23![Southwest logo]()
$432
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/73:20 pm
DSM
- BUF
2 stops7h 35m
United Airlines
Mon 5/117:00 am
BUF
- DSM
1 stop4h 37m
United Airlines
Deal found 4/23![United Airlines logo]()
$437
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/123:15 pm
DSM
- BUF
1 stop4h 10m
Southwest
Sat 5/168:00 am
BUF
- DSM
1 stop4h 30m
Southwest
Deal found 4/27![Southwest logo]()
$487
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/148:56 am
DSM
- BUF
1 stop4h 25m
American Airlines
Tue 5/195:32 pm
BUF
- DSM
1 stop5h 21m
American Airlines
Deal found 4/24![American Airlines logo]()
$411
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/143:20 pm
DSM
- BUF
1 stop4h 41m
United Airlines
Tue 5/196:04 am
BUF
- DSM
2 stops9h 20m
United Airlines
Deal found 4/24![United Airlines logo]()
$426
This Southwest deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:25 am
DSM
- BUF
2 stops10h 15m
Southwest
Tue 5/194:00 pm
BUF
- DSM
2 stops7h 10m
Southwest
Deal found 4/24![Southwest logo]()
$478
One-way flights from Des Moines to BuffaloSearch for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated April 28, 2026.
Search for one-way flight options from Des Moines to Buffalo. Find affordable one-way fares based on user searches. Data last updated April 28, 2026.
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:33 pm
DSM
- BUF
1 stop4h 31m
American Airlines
Deal found 4/27![American Airlines logo]()
$188
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/34:40 pm
DSM
- BUF
2 stops40h 59m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$191
Find flight deals from Des Moines to Buffalo
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Buffalo (BUF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $373 (United Airlines) |
One-way from | $188 (American Airlines) |
Popular in | March |
Cheapest in | June |
Average price | $364 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Sat 6/6
1:05 pm-9:03 pm
1 stop6h 58m
Buffalo
Tue 6/9
7:00 am-10:27 am
1 stop4h 27m
$373
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Fri 6/5
1:37 pm-10:36 pm
1 stop7h 59m
Buffalo
Fri 6/12
1:49 pm-8:43 pm
1 stop7h 54m
$382
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Thu 6/25
1:05 pm-8:41 pm
1 stop6h 36m
Buffalo
Thu 7/2
7:00 am-12:30 pm
1 stop6h 30m
$407
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Mon 7/27
1:41 pm-10:52 pm
1 stop8h 11m
Buffalo
Sun 8/2
6:27 am-1:05 pm
1 stop7h 38m
$415
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Tue 6/2
11:23 am-4:46 pm
1 stop4h 23m
Buffalo
Wed 6/3
9:00 am-4:15 pm
1 stop8h 15m
$415
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Thu 6/25
4:40 pm-12:10 am
2 stops6h 30m
Buffalo
Thu 7/2
2:50 pm-11:30 pm
2 stops9h 40m
$427
Cheapest one-way
Quickest one-way
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Fri 7/3
6:33 pm-12:04 am
1 stop4h 31m
$188
Des MoinesBuffalo
DSM - BUF
DSMBUF
Des Moines
Fri 7/3
4:40 pm-10:39 am
2 stops40h 59m
$191
Sorted by cheapest first
Compare providers for flights from Des Moines to Buffalo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Buffalo in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Buffalo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Buffalo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Buffalo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Buffalo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Buffalo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Buffalo
Have a flexible travel schedule? Discover the best time to fly to Buffalo from Des Moines with our price prediction graph.
DSM-BUF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Buffalo
What is the cheapest month to book a flight from Des Moines to Buffalo?
Currently, June is the cheapest month in which you can book a flight from Des Moines to Buffalo (average of $148). Flying from Des Moines to Buffalo in March is currently the most expensive (average of $736). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Buffalo?
Reviews of airlines servicing Buffalo
Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated April 28, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Des Moines to Buffalo. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.8
Crew
8.5
Comfort
7.9
Overall
7.9
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Boarding
8.1
Entertainment
7.8
Crew
8.5
Comfort
7.9
Overall
7.9
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Boarding
8.1
Entertainment
7.8
Crew
8.5
Comfort
7.9
Overall
7.9
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Boarding
8.1
Entertainment
7.8
Crew
8.5
Comfort
7.9
Overall
7.9
Food
7.2
Reviews
1 / 20
10.0
ExcellentLucy,Nov 2023
ATL - JFK
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Buffalo?
Book flights to Buffalo if you plan to visit one of these locationsLockport
Cheektowaga
Batavia
Williamsville
Orchard Park
Eden
Amherst
West Seneca
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Other flights to Buffalo
Explore flights to Buffalo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 28, 2026.
Complete your trip
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Des Moines and Buffalo flights
Browse other Des Moines and Buffalo flight options. Last updated on April 28, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on April 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Buffalo
Discover the top 3 airlines that operate flights from Des Moines to Buffalo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$148 | Average$332 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$238 | Average$334 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$341 | Average$441 | FlexibilityNo cancel fee | On-time69% |