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$355+ Cheap flights from Knoxville (TYS) to Istanbul (IST)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — IST
Mar 27 — Apr 31
Fri 3/27
Fri 4/3
1 adult, Economy
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Cheap flight deals from Knoxville to Istanbul

Cheapest flights from Knoxville to Istanbul
Explore the most affordable flight options available from Knoxville to Istanbul. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 25, 2026.

This United Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/710:49 am
TYS
-
IST
2 stops27h 26m
United Airlines
Wed 4/155:40 am
IST
-
TYS
2 stops25h 01m
United Airlines
Deal found 2/22$628
This Delta deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/245:24 pm
TYS
-
IST
2 stops27h 26m
Delta
Tue 4/216:00 am
IST
-
TYS
2 stops17h 42m
Delta
Deal found 2/24$639
This Delta deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/243:13 pm
TYS
-
IST
2 stops29h 37m
Delta
Thu 4/236:00 am
IST
-
TYS
2 stops17h 42m
Delta
Deal found 2/24$689
This Delta deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:20 pm
TYS
-
IST
2 stops49h 00m
Delta
Wed 4/154:25 am
IST
-
TYS
2 stops23h 10m
Delta
Deal found 2/22$695
This Gurufare deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:10 pm
TYS
-
IST
2 stops16h 45m
Multiple Airlines
Tue 4/216:00 am
IST
-
TYS
2 stops18h 08m
Multiple Airlines
Deal found 2/24$699
This United Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/82:25 pm
TYS
-
IST
2 stops24h 00m
United Airlines
Tue 4/145:40 am
IST
-
TYS
2 stops23h 58m
United Airlines
Deal found 2/22$728
This Delta deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/511:18 am
TYS
-
IST
2 stops31h 02m
Delta
Mon 4/134:25 am
IST
-
TYS
2 stops26h 29m
Delta
Deal found 2/22$739
This Delta deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:20 pm
TYS
-
IST
2 stops49h 00m
Delta
Mon 4/135:20 pm
IST
-
TYS
2 stops30h 22m
Delta
Deal found 2/22$745
This Delta deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/811:18 am
TYS
-
IST
2 stops33h 12m
Delta
Mon 4/135:20 pm
IST
-
TYS
2 stops30h 22m
Delta
Deal found 2/22$752
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:00 am
TYS
-
IST
2 stops31h 25m
United Airlines
Thu 4/305:40 am
IST
-
TYS
2 stops25h 04m
United Airlines
Deal found 2/23$778
This Delta deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:10 pm
TYS
-
IST
2 stops27h 40m
Delta
Wed 4/226:00 am
IST
-
TYS
2 stops17h 42m
Delta
Deal found 2/24$789
This Delta deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/245:24 pm
TYS
-
IST
2 stops27h 26m
Delta
Fri 4/246:00 am
IST
-
TYS
2 stops23h 59m
Delta
Deal found 2/24$790

Find flight deals from Knoxville to Istanbul

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Istanbul (IST). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 25, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$628
(United Airlines)

One-way from

$355
(Kiwi.com)

Popular in

June

Cheapest in

February

Average price

$554
Provider with most accurate pricing for Knoxville McGhee Tyson-Istanbul flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Istanbul flights.
Search Deals
From Knoxville McGhee Tyson to Istanbul
Search Deals
One-way flight from Knoxville McGhee Tyson to Istanbul
Search Deals
Highest demand for flights based on searches. 23% potential increase in price ($308 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($47 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Istanbul that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 25, 2026.
Use the filters below to find and compare flights from Knoxville to Istanbul Airport that are best for you.

Fly from

Knoxville

Fly to

Istanbul

Route

Depart

Return

Price

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

Sun 4/5

7:20 pm-9:35 pm

2 stops19h 15m

Istanbul

Thu 4/16

5:40 am-11:41 pm

2 stops25h 01m

$628

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

Sun 4/5

7:20 pm-9:35 pm

2 stops19h 15m

Istanbul

Wed 4/15

5:40 am-11:41 pm

2 stops25h 01m

$628

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

Tue 4/7

7:20 pm-9:15 pm

2 stops18h 55m

Istanbul

Tue 4/14

5:40 am-7:42 pm

2 stops21h 02m

$628

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

Wed 4/8

2:25 pm-9:25 pm

2 stops24h 00m

Istanbul

Thu 4/16

5:40 am-11:41 pm

2 stops25h 01m

$628

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

Fri 4/24

7:00 am-9:25 pm

2 stops31h 25m

Istanbul

Thu 4/30

5:40 am-11:44 pm

2 stops25h 04m

$778

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

Thu 4/9

9:40 am-9:35 pm

2 stops28h 55m

Istanbul

Thu 4/16

5:40 am-11:41 pm

2 stops25h 01m

$818

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

Sat 4/4

5:20 pm-1:20 am

2 stops49h 00m

Istanbul

Sun 4/12

5:20 pm-11:54 pm

2 stops37h 34m

$895

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

Tue 3/24

7:25 pm-10:45 pm

2 stops20h 20m

Istanbul

Sun 4/19

5:50 am-10:29 pm

2 stops23h 39m

$908

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

Mon 3/23

5:43 pm-10:45 pm

2 stops22h 02m

Istanbul

Thu 4/23

5:40 am-10:29 pm

2 stops23h 49m

$928

KnoxvilleIstanbul

TYS - IST

TYSIST

Knoxville McGhee Tyson

Mon 3/23

5:43 pm-10:45 pm

2 stops22h 02m

Istanbul

Mon 4/20

1:55 pm-10:50 am

2 stops27h 55m

$984

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/24

Showing 1-10 of 17 results
1
2

Compare providers for flights from Knoxville to Istanbul

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Istanbul in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*2 stars
OvagoPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Istanbul Airport flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Istanbul Airport flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Istanbul Airport flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Istanbul Airport flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Istanbul Airport flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Istanbul

Have a flexible travel schedule? Discover the best time to fly to Istanbul from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Istanbul

Get insights into the airlines that provide service to Istanbul. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Istanbul. Reviews last updated February 25, 2026.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Istanbul Airport have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,238 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,238 reviews
Delta
7.9
Good
8,238 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,345 reviews
Delta
7.9
Good
8,238 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,345 reviews
Delta
7.9
Good
8,238 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
British Airways
6.7
Okay
7,764 reviews
Delta
7.9
Good
8,238 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Istanbul. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Istanbul?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Istanbul. On average, McGhee Tyson has 0 outbound flights to Istanbul per day from 4 airlines. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Istanbul Airport?

    For as low as $628, United Airlines can have you in Istanbul Airport from Knoxville in 19h 15m. The distance from Knoxville to Istanbul Airport is about 5617 mi.

  • What are the cheapest airlines flying from Knoxville to Istanbul Airport round-trip?

    Our cheapest airline available from Knoxville to Istanbul Airport is United Airlines. Our recent data shows that you can find tickets from as low as $628 on this airline. Additional options worth looking into are British Airways and American Airlines, starting at $758 and $770 round-trip. You may be able to fly from Knoxville to Istanbul Airport for 38% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Istanbul that include hotel bookings?

    Yes. In addition to deals on Knoxville to Istanbul flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Istanbul?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Istanbul.

  • Can I find deals for business class flights from Knoxville to Istanbul?

    Yes. Cheapflights offers flight deals from Knoxville to Istanbul by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Istanbul Airport?

Book flights to Istanbul Airport if you plan to visit one of these locations
Yalova

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Alternative routes for Knoxville to Istanbul

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Nashville to Istanbul flights

Top 4 airlines flying from Knoxville to Istanbul

Discover the top 4 airlines that operate flights from Knoxville to Istanbul. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 25, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$628Average$1,160FlexibilityNo cancel feeOn-time69%
British AirwaysCheapest$758Average$1,045FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$770Average$1,016FlexibilityNo cancel feeOn-time71%
DeltaCheapest$1,061Average$1,316FlexibilityNo cancel feeOn-timeN/A

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