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Syracuse

$147+ Cheap flights from Iowa to Syracuse (SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SYR
Apr 12 — Apr 191
Sun 4/12
Sun 4/19
1 adult, Economy
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Cheap flight deals from Iowa to Syracuse

Cheapest flights from Iowa to Syracuse
Explore the most affordable flight options available from Iowa to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 13, 2026.

This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/183:48 pm
MLI
-
SYR
1 stop6h 30m
American Airlines
Sat 4/255:40 am
SYR
-
MLI
1 stop7h 41m
American Airlines
Deal found 3/9$271
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2212:00 pm
DSM
-
SYR
1 stop5h 34m
American Airlines
Wed 4/297:26 pm
SYR
-
DSM
1 stop5h 23m
American Airlines
Deal found 3/9$291
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:11 pm
MLI
-
SYR
1 stop5h 52m
Delta
Sat 4/2511:51 am
SYR
-
MLI
2 stops11h 44m
Delta
Deal found 3/12$296
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/173:00 pm
DSM
-
SYR
1 stop7h 04m
American Airlines
Sun 4/195:40 am
SYR
-
DSM
1 stop5h 46m
American Airlines
Deal found 3/9$299
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/184:02 pm
OMA
-
SYR
1 stop6h 03m
American Airlines
Sat 4/257:26 pm
SYR
-
OMA
1 stop5h 33m
American Airlines
Deal found 3/12$310
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/33:20 pm
MLI
-
SYR
1 stop4h 27m
United Airlines
Sun 4/56:30 am
SYR
-
MLI
1 stop4h 28m
United Airlines
Deal found 3/12$314
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:08 pm
OMA
-
SYR
1 stop7h 00m
United Airlines
Tue 11/36:30 am
SYR
-
OMA
1 stop5h 03m
United Airlines
Deal found 3/9$315
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:00 am
OMA
-
SYR
2 stops7h 15m
United Airlines
Sat 6/205:44 pm
SYR
-
OMA
1 stop6h 36m
United Airlines
Deal found 3/10$316
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:00 am
DSM
-
SYR
1 stop7h 09m
Allegiant Air
Sun 6/78:32 pm
SYR
-
DSM
1 stop21h 27m
Allegiant Air
Deal found 3/11$318
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/92:50 pm
OMA
-
SYR
1 stop7h 14m
American Airlines
Sat 4/117:26 pm
SYR
-
OMA
1 stop5h 33m
American Airlines
Deal found 3/13$319
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/281:35 pm
DSM
-
SYR
1 stop9h 09m
United Airlines
Sun 5/316:15 am
SYR
-
DSM
1 stop5h 07m
United Airlines
Deal found 3/10$319
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/275:00 am
CID
-
SYR
1 stop5h 11m
American Airlines
Tue 3/315:15 am
SYR
-
CID
1 stop4h 58m
American Airlines
Deal found 3/12$319

Find flight deals from Iowa to Syracuse

Keep the following information in mind while searching for Iowa to Syracuse flight deals. Data was last updated March 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$271
(American Airlines)

One-way from

$147
(Kiwi.com)

Popular in

March

Cheapest in

May

Average price

$649
Provider with most accurate pricing for Des Moines-Syracuse Hancock Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Syracuse Hancock Intl flights.
Search Deals
From Iowa to Syracuse Hancock Intl
Search Deals
One-way flight from Iowa to Syracuse Hancock Intl
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($52 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($26 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 13, 2026.
Use the filters below to find and compare flights from Iowa to Syracuse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MolineSyracuse

MLI - SYR

MLISYR

Moline Quad-City

Sat 4/18

3:48 pm-11:18 pm

1 stop6h 30m

Syracuse Hancock Intl

Sat 4/25

5:40 am-12:21 pm

1 stop7h 41m

$271
Quickest round-trip

MolineSyracuse

MLI - SYR

MLISYR

Moline Quad-City

Fri 4/3

3:20 pm-8:47 pm

1 stop4h 27m

Syracuse Hancock Intl

Sun 4/5

6:30 am-9:58 am

1 stop4h 28m

$314

OmahaSyracuse

OMA - SYR

OMASYR

Omaha Eppley Airfield

Wed 4/8

2:50 pm-11:04 pm

1 stop7h 14m

Syracuse Hancock Intl

Sat 4/11

5:46 pm-12:22 am

1 stop7h 36m

$315

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Thu 5/28

1:35 pm-11:44 pm

1 stop9h 09m

Syracuse Hancock Intl

Sun 5/31

6:15 am-10:22 am

1 stop5h 07m

$319

OmahaSyracuse

OMA - SYR

OMASYR

Omaha Eppley Airfield

Thu 4/16

1:52 pm-11:21 pm

1 stop8h 29m

Syracuse Hancock Intl

Sat 4/18

6:00 am-3:44 pm

2 stops10h 44m

$320

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Thu 6/4

6:00 am-2:09 pm

1 stop7h 09m

Syracuse Hancock Intl

Sun 6/7

8:32 pm-4:59 pm

1 stop21h 27m

$323

Cedar RapidsSyracuse

CID - SYR

CIDSYR

Cedar Rapids

Fri 3/27

4:48 pm-12:37 am

1 stop6h 49m

Syracuse Hancock Intl

Tue 3/31

3:25 pm-11:04 pm

2 stops8h 39m

$324

OmahaSyracuse

OMA - SYR

OMASYR

Omaha Eppley Airfield

Fri 4/10

1:52 pm-11:21 pm

1 stop8h 29m

Syracuse Hancock Intl

Sun 4/12

6:30 am-10:32 am

1 stop5h 02m

$360

MolineSyracuse

MLI - SYR

MLISYR

Moline Quad-City

Wed 4/29

10:35 am-5:01 pm

1 stop5h 26m

Syracuse Hancock Intl

Sat 5/2

10:37 am-3:12 pm

1 stop5h 35m

$361

Cedar RapidsSyracuse

CID - SYR

CIDSYR

Cedar Rapids

Sat 4/18

1:28 pm-8:48 pm

1 stop6h 20m

Syracuse Hancock Intl

Wed 4/22

6:30 am-12:47 pm

1 stop7h 17m

$361

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/12

Showing 1-10 of 44 resultsSorted by cheapest first
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Best time to book a flight from Iowa to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Syracuse

What is the cheapest month to book a flight from Iowa to Syracuse?

Currently, May is the cheapest month in which you can book a flight from Iowa to Syracuse (average of $178). Flying from Iowa to Syracuse in January is currently the most expensive (average of $317). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Syracuse from Iowa?

    Most people fly into Syracuse Hancock Intl (SYR) if they book a flight to Syracuse from Iowa. Hancock Intl is conveniently located just 4.8 mi from Syracuse’s city center.

  • How long is the flight from Iowa to Syracuse?

    A quick flight from Iowa to Syracuse can take about 4h 27m. American Airlines provides one of the quickest options available for as low as $314. Iowa and Syracuse are separated by a distance of 744 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Iowa to Syracuse?

    The most popular flight routes from Iowa to Syracuse are Des Moines - Syracuse Hancock Intl, Moline Quad-City - Syracuse Hancock Intl and Omaha Eppley Airfield - Syracuse Hancock Intl.

  • Can I find deals for flights from Iowa to Syracuse that include hotel bookings?

    Yes. In addition to deals on Iowa to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Syracuse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Syracuse.

  • Can I find deals for business class flights from Iowa to Syracuse?

    Yes. Cheapflights offers flight deals from Iowa to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Syracuse?

    Currently, May is the cheapest month in which you can book a flight from Iowa to Syracuse (average of $178). Flying from Iowa to Syracuse in January is currently the most expensive (average of $317). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
East Syracuse
Liverpool
Waterloo

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Alternative routes for Iowa to Syracuse

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Iowa to Syracuse

Discover the top 3 airlines that operate flights from Iowa to Syracuse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 13, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$236Average$383FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$361FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$258Average$404FlexibilityNo cancel feeOn-time69%

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