HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Syracuse

$148+ Cheap flights from Des Moines to Syracuse (DSM - SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SYR
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Syracuse with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Syracuse

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Syracuse (SYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$259
(American Airlines)

One-way from

$148
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$367
From Des Moines to Syracuse Hancock Intl
Search Deals
One-way flight from Des Moines to Syracuse Hancock Intl
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($23 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($22 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Des Moines to Syracuse

Cheapest flights from Des Moines to Syracuse
Explore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:07 pmDSM - SYR
1 stop4h 22mAmerican Airlines
Mon 11/37:56 pmSYR - DSM
1 stop4h 54mAmerican Airlines
Deal found 9/10$259
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:00 amDSM - SYR
2 stops7h 25mAmerican Airlines
Sat 11/111:28 amSYR - DSM
1 stop5h 50mAmerican Airlines
Deal found 9/10$265
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/31:00 pmDSM - SYR
1 stop7h 28mUnited Airlines
Thu 10/96:15 amSYR - DSM
1 stop5h 17mUnited Airlines
Deal found 9/10$274
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1311:25 amDSM - SYR
1 stop21h 52mAllegiant Air
Sat 10/256:01 pmSYR - DSM
1 stop16h 50mAllegiant Air
Deal found 9/10$332
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2511:31 amDSM - SYR
3 stops10h 39mUnited Airlines
Sat 11/16:15 amSYR - DSM
2 stops10h 58mUnited Airlines
Deal found 9/10$344
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/266:22 pmDSM - SYR
1 stop4h 58mAmerican Airlines
Sun 11/25:00 amSYR - DSM
1 stop8h 31mAmerican Airlines
Deal found 9/11$391

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Des Moines to Syracuse that are best for you.

Fly from

Des Moines

Fly to

Syracuse

Route

Depart

Return

Price

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 12/23

5:47 pm-11:15 pm

1 stop4h 28m

Syracuse Hancock Intl

Tue 12/30

6:00 am-9:48 am

1 stop4h 48m

$259

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Thu 10/30

6:07 pm-11:29 pm

1 stop4h 22m

Syracuse Hancock Intl

Mon 11/3

7:56 pm-11:50 pm

1 stop4h 54m

$259

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sun 12/21

5:47 pm-11:15 pm

1 stop4h 28m

Syracuse Hancock Intl

Tue 12/30

6:00 am-9:48 am

1 stop4h 48m

$259

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sat 10/25

5:15 pm-12:20 am

1 stop6h 05m

Syracuse Hancock Intl

Sat 11/1

6:00 am-9:19 am

1 stop4h 19m

$259

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sat 10/25

6:00 am-2:25 pm

2 stops7h 25m

Syracuse Hancock Intl

Sat 11/1

11:28 am-4:18 pm

1 stop5h 50m

$265

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 10/3

1:00 pm-9:28 pm

1 stop7h 28m

Syracuse Hancock Intl

Thu 10/9

6:15 am-10:32 am

1 stop5h 17m

$274

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 10/15

7:30 am-11:21 am

3 stops26h 51m

$148

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 10/15

6:00 am-12:04 pm

1 stop5h 04m

$271

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 10/14

5:56 pm-11:04 pm

1 stop4h 08m

$271

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 9/17

10:14 am-5:20 pm

3 stops30h 06m

$332

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 17 results
1
2

Best time to book a flight from Des Moines to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Syracuse

What is the cheapest month to book a flight from Des Moines to Syracuse?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $272). Flying from Des Moines to Syracuse in July is currently the most expensive (average of $387). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Syracuse

Get insights into the airlines that provide service to Syracuse. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Syracuse. Reviews last updated September 11, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Des Moines to Syracuse by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Syracuse?

    A quick flight from Des Moines to Syracuse can take about 4h 22m. Delta provides one of the quickest options available for as low as $259. Des Moines and Syracuse are separated by a distance of 901 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Syracuse round-trip?

    Our cheapest airline available from Des Moines to Syracuse is Delta. Our recent data shows that you can find tickets from as low as $236 on this airline. An additional option worth looking into is American Airlines, starting at $250. Delta is priced at 42% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Syracuse one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $271. However, be on the lookout for offers from Delta and Allegiant Air, as they are both options that can get you from Des Moines to Syracuse for a low price.

  • Can I find deals for flights from Des Moines to Syracuse that include hotel bookings?

    Yes. In addition to deals on Des Moines to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Syracuse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Syracuse.

  • Can I find deals for business class flights from Des Moines to Syracuse?

    Yes. Cheapflights offers flight deals from Des Moines to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Syracuse?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $272). Flying from Des Moines to Syracuse in July is currently the most expensive (average of $387). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
Liverpool
Cicero
East Syracuse
Waterloo

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Syracuse

See prices for flight routes from nearby airports that may be better suited for you.
Omaha to LaGuardia flights
Des Moines to LaGuardia flights
Omaha to John F Kennedy Intl flights
Des Moines to John F Kennedy Intl flights
Omaha to Newark flights
Cedar Rapids to John F Kennedy Intl flights
Cedar Rapids to LaGuardia flights
Cedar Rapids to Newark flights
Des Moines to Newark flights
Omaha to Albany flights
Moline to Newark flights
Moline to John F Kennedy Intl flights
Moline to LaGuardia flights
Omaha to White Plains flights
Omaha to Buffalo flights
Cedar Rapids to Syracuse flights
Des Moines to Buffalo flights
Des Moines to Albany flights
Omaha to Syracuse flights
Des Moines to Stewart flights
Moline to Rochester flights
Omaha to Binghamton flights
Omaha to Rochester flights
Cedar Rapids to Albany flights
Waterloo to John F Kennedy Intl flights
Cedar Rapids to Buffalo flights
Waterloo to Newark flights
Moline to Buffalo flights
Des Moines to White Plains flights
Moline to White Plains flights
Waterloo to LaGuardia flights
Cedar Rapids to Rochester flights
Moline to Syracuse flights
Des Moines to Rochester flights
Moline to Albany flights
Sioux City to LaGuardia flights
La Crosse to Newark flights
Cedar Rapids to Stewart flights
La Crosse to LaGuardia flights
Cedar Rapids to White Plains flights
La Crosse to John F Kennedy Intl flights
Cedar Rapids to Binghamton flights
Sioux City to Newark flights
Omaha to Islip flights
La Crosse to White Plains flights
Des Moines to Elmira flights
Waterloo to Rochester flights
Cedar Rapids to Ithaca flights
Dubuque to John F Kennedy Intl flights

Top 2 airlines flying from Des Moines to Syracuse

Discover the top 2 airlines that operate flights from Des Moines to Syracuse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$236Average$388FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$250Average$408FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.