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Syracuse

$279+ Cheap flights from Des Moines to Syracuse (DSM - SYR)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/9. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SYR
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Cheap flight deals from Des Moines to Syracuse

Cheapest flights from Des Moines to Syracuse
Explore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:00 am
DSM
-
SYR
1 stop4h 06m
American Airlines
Mon 4/137:20 pm
SYR
-
DSM
1 stop5h 09m
American Airlines
Deal found 1/25$279
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:25 pm
DSM
-
SYR
1 stop4h 31m
Delta
Wed 6/176:00 am
SYR
-
DSM
1 stop4h 19m
Delta
Deal found 1/27$315
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/281:32 pm
DSM
-
SYR
1 stop8h 49m
United Airlines
Sat 5/26:15 am
SYR
-
DSM
1 stop5h 22m
United Airlines
Deal found 1/26$341
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1011:30 am
DSM
-
SYR
2 stops10h 58m
United Airlines
Wed 6/176:30 am
SYR
-
DSM
1 stop4h 50m
United Airlines
Deal found 1/26$346
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/285:16 pm
DSM
-
SYR
1 stop5h 35m
Delta
Sat 1/315:50 am
SYR
-
DSM
1 stop4h 45m
Delta
Deal found 1/27$383
This Delta deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:47 pm
DSM
-
SYR
1 stop4h 22m
Delta
Wed 3/185:50 am
SYR
-
DSM
1 stop4h 56m
Delta
Deal found 1/25$385

Find flight deals from Des Moines to Syracuse

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Syracuse (SYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$279
(American Airlines)

Popular in

March

Cheapest in

September

Average price

$398
Provider with most accurate pricing for Des Moines-Syracuse Hancock Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Syracuse Hancock Intl flights.
Search Deals
From Des Moines to Syracuse Hancock Intl
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($53 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($25 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Des Moines to Syracuse that are best for you.

Fly from

Des Moines

Fly to

Syracuse

Route

Depart

Return

Price

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Thu 4/9

6:00 am-11:06 am

1 stop4h 06m

Syracuse Hancock Intl

Mon 4/13

7:20 pm-11:29 pm

1 stop5h 09m

$279

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 6/10

5:25 pm-10:56 pm

1 stop4h 31m

Syracuse Hancock Intl

Wed 6/17

6:00 am-9:19 am

1 stop4h 19m

$315

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 4/28

1:32 pm-11:21 pm

1 stop8h 49m

Syracuse Hancock Intl

Sat 5/2

6:15 am-10:37 am

1 stop5h 22m

$341

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 6/10

11:30 am-11:28 pm

2 stops10h 58m

Syracuse Hancock Intl

Wed 6/17

6:30 am-10:20 am

1 stop4h 50m

$346

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Compare providers for flights from Des Moines to Syracuse

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Syracuse in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
MytripPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Syracuse flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Syracuse flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Syracuse flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Syracuse flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Syracuse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Syracuse

What is the cheapest month to book a flight from Des Moines to Syracuse?

Currently, April is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $236). Flying from Des Moines to Syracuse in March is currently the most expensive (average of $597). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Syracuse

Get insights into the airlines that provide service to Syracuse. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Syracuse. Reviews last updated January 27, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Des Moines to Syracuse by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,118 reviews

Crew

8.5

Food

7.2

Entertainment

7.8

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
7.9
Good
8,118 reviews
Delta
7.9
Good
8,118 reviews

Crew

8.5

Food

7.2

Entertainment

7.8

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
11,197 reviews
Delta
7.9
Good
8,118 reviews

Crew

8.5

Food

7.2

Entertainment

7.8

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Syracuse?

    A quick flight from Des Moines to Syracuse can take about 4h 06m. American Airlines provides one of the quickest options available for as low as $279. Des Moines and Syracuse are separated by a distance of 901 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Syracuse round-trip?

    Our cheapest airline available from Des Moines to Syracuse is Delta. Our recent data shows that you can find tickets from as low as $236 on this airline. An additional option worth looking into is American Airlines, starting at $258. Delta is priced at 36% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Syracuse that include hotel bookings?

    Yes. In addition to deals on Des Moines to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Syracuse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Syracuse.

  • Can I find deals for business class flights from Des Moines to Syracuse?

    Yes. Cheapflights offers flight deals from Des Moines to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Syracuse?

    Currently, April is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $236). Flying from Des Moines to Syracuse in March is currently the most expensive (average of $597). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
Liverpool
East Syracuse
Waterloo

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Alternative routes for Des Moines to Syracuse

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Des Moines to Syracuse

Discover the top 2 airlines that operate flights from Des Moines to Syracuse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$236Average$383FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$376FlexibilityNo cancel feeOn-time71%

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