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$211+ Cheap flights from Des Moines to Syracuse (DSM - SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SYR
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
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Cheap flight deals from Des Moines to Syracuse

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Syracuse (SYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2025.

Round-trip from

$256
(American Airlines)

One-way from

$211
(Mytrip)

Popular in

December

Cheapest in

April

Average price

$445
From Des Moines to Syracuse Hancock Intl
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One-way flight from Des Moines to Syracuse Hancock Intl
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Highest demand for flights based on searches. 5% potential increase in price ($21 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Des Moines to Syracuse

Cheapest flights from Des Moines to Syracuse
Explore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/103:50 pmDSM - SYR
1 stop6h 50mAmerican Airlines
Wed 9/176:10 amSYR - DSM
1 stop7h 55mAmerican Airlines
Deal found 7/27$256
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/126:00 amDSM - SYR
1 stop4h 52mDelta
Sat 8/166:10 amSYR - DSM
1 stop4h 27mDelta
Deal found 7/28$289
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/73:25 pmDSM - SYR
1 stop5h 03mUnited Airlines
Sun 10/126:15 amSYR - DSM
1 stop5h 17mUnited Airlines
Deal found 7/29$329
This Mytrip deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/116:30 amDSM - SYR
2 stops30h 52mMultiple Airlines
Thu 9/187:28 pmSYR - DSM
2 stops19h 04mMultiple Airlines
Deal found 7/27$490

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Des Moines to Syracuse that are best for you.

Fly from

Des Moines

Fly to

Syracuse

Route

Depart

Return

Price

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 9/10

3:50 pm-11:40 pm

1 stop6h 50m

Syracuse Hancock Intl

Wed 9/17

6:10 am-1:05 pm

1 stop7h 55m

$256

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 8/12

6:00 am-11:52 am

1 stop4h 52m

Syracuse Hancock Intl

Sat 8/16

6:10 am-9:37 am

1 stop4h 27m

$289

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 10/7

3:25 pm-9:28 pm

1 stop5h 03m

Syracuse Hancock Intl

Sun 10/12

6:15 am-10:32 am

1 stop5h 17m

$329

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Thu 9/11

6:30 am-2:22 pm

2 stops30h 52m

Syracuse Hancock Intl

Thu 9/18

7:28 pm-1:32 pm

2 stops19h 04m

$490

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sun 8/24

7:15 pm-5:16 pm

2 stops21h 01m

$211

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sun 8/24

5:55 pm-10:47 pm

1 stop3h 52m

$242

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sun 8/24

6:30 am-6:42 pm

3 stops35h 12m

$436

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Best time to book a flight from Des Moines to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Syracuse

What is the cheapest month to book a flight from Des Moines to Syracuse?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $272). Flying from Des Moines to Syracuse in July is currently the most expensive (average of $388). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Syracuse?

Reviews of airlines servicing Syracuse

Get insights into the airlines that provide service to Syracuse. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Syracuse. Reviews last updated July 29, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Des Moines to Syracuse by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,977 reviews

Food

7.3

Crew

8.5

Boarding

8.2

Overall

8.0

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
8.0
Very good
7,977 reviews
Delta
8.0
Very good
7,977 reviews

Food

7.3

Crew

8.5

Boarding

8.2

Overall

8.0

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
United Airlines
7.4
Good
8,899 reviews
Delta
8.0
Very good
7,977 reviews

Food

7.3

Crew

8.5

Boarding

8.2

Overall

8.0

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,977 reviews

Food

7.3

Crew

8.5

Boarding

8.2

Overall

8.0

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Allegiant Air
7.2
Good
703 reviews
Delta
8.0
Very good
7,977 reviews

Food

7.3

Crew

8.5

Boarding

8.2

Overall

8.0

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Syracuse round-trip?

    Our cheapest airline available from Des Moines to Syracuse is American Airlines. Our recent data shows that you can find tickets from as low as $256 on this airline. Additional options worth looking into are Delta and United Airlines, starting at $289 and $329 round-trip. American Airlines is priced at 38% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Syracuse that include hotel bookings?

    Yes. In addition to deals on Des Moines to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Syracuse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Syracuse.

  • Can I find deals for business class flights from Des Moines to Syracuse?

    Yes. Cheapflights offers flight deals from Des Moines to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Syracuse?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $272). Flying from Des Moines to Syracuse in July is currently the most expensive (average of $388). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
Auburn
Liverpool
Cicero
East Syracuse
Waterloo

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Alternative routes for Des Moines to Syracuse

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Top 2 airlines flying from Des Moines to Syracuse

Discover the top 2 airlines that operate flights from Des Moines to Syracuse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$236Average$363FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$250Average$408FlexibilityNo cancel feeOn-time71%

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