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$248+ Cheap flights from Des Moines to Syracuse (DSM - SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SYR
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheap flight deals from Des Moines to Syracuse

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Syracuse (SYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2025.

Round-trip from

$259
(Delta)

One-way from

$248
(Delta)

Popular in

December

Cheapest in

April

Average price

$488
From Des Moines to Syracuse Hancock Intl
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One-way flight from Des Moines to Syracuse Hancock Intl
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Highest demand for flights based on searches. 2% potential increase in price ($12 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Des Moines to Syracuse

Cheapest flights from Des Moines to Syracuse
Explore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1311:23 amDSM - SYR
1 stop5h 21mDelta
Sat 8/168:30 amSYR - DSM
1 stop6h 37mDelta
Deal found 6/10$259
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/295:00 amDSM - SYR
2 stops7h 14mAmerican Airlines
Tue 8/58:20 pmSYR - DSM
1 stop4h 24mAmerican Airlines
Deal found 6/12$264
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/163:49 pmDSM - SYR
1 stop15h 57mAllegiant Air
Wed 7/238:34 pmSYR - DSM
2 stops27h 04mAllegiant Air
Deal found 6/11$284
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1611:00 amDSM - SYR
2 stops22h 46mMultiple Airlines
Wed 7/238:34 pmSYR - DSM
2 stops27h 04mMultiple Airlines
Deal found 6/10$301
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/283:25 pmDSM - SYR
1 stop4h 40mUnited Airlines
Sat 9/66:25 amSYR - DSM
2 stops10h 48mUnited Airlines
Deal found 6/11$334

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Des Moines to Syracuse that are best for you.

Fly from

Des Moines

Fly to

Syracuse

Route

Depart

Return

Price

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 8/13

11:23 am-5:44 pm

1 stop5h 21m

Syracuse Hancock Intl

Sat 8/16

8:30 am-2:07 pm

1 stop6h 37m

$259

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 7/29

5:00 am-1:14 pm

2 stops7h 14m

Syracuse Hancock Intl

Tue 8/5

8:20 pm-11:44 pm

1 stop4h 24m

$264

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 7/16

3:49 pm-8:46 am

1 stop15h 57m

Syracuse Hancock Intl

Wed 7/23

8:34 pm-10:38 pm

2 stops27h 04m

$284

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 7/16

11:00 am-10:46 am

2 stops22h 46m

Syracuse Hancock Intl

Wed 7/23

8:34 pm-10:38 pm

2 stops27h 04m

$301

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Thu 8/28

3:25 pm-9:05 pm

1 stop4h 40m

Syracuse Hancock Intl

Sat 9/6

6:25 am-4:13 pm

2 stops10h 48m

$334

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Thu 7/24

3:39 pm-11:13 pm

1 stop6h 34m

$248

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Thu 7/24

5:00 am-1:14 pm

2 stops7h 14m

$276

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 7/11

1:45 pm-11:30 pm

1 stop8h 45m

$280

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from Des Moines to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Syracuse

What is the cheapest month to book a flight from Des Moines to Syracuse?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $272). Flying from Des Moines to Syracuse in July is currently the most expensive (average of $379). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Syracuse by month

Plan your trip to Syracuse by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Syracuse ranges from 2.1 - 3.8 inches per month. July is typically the wettest month, when rainfall can reach 3.8 in. February is typically the driest time to visit Syracuse when rainfall is around 2.1 in.

Temperature in Syracuse by month

Plan your trip to Syracuse by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Syracuse, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Syracuse

Get insights into the airlines that provide service to Syracuse. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Syracuse. Reviews last updated June 12, 2025.
To help decide which airline to fly from Des Moines to Syracuse, see what other customers have to say about Delta, United Airlines and Allegiant Air. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,946 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
8.0
Very good
7,946 reviews
Delta
8.0
Very good
7,946 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,946 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Allegiant Air
7.3
Good
725 reviews
Delta
8.0
Very good
7,946 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,946 reviews

Food

7.3

Entertainment

7.9

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Syracuse round-trip?

    Our cheapest airline available from Des Moines to Syracuse is Delta. Our recent data shows that you can find tickets from as low as $259 on this airline. Additional options worth looking into are American Airlines and Allegiant Air, starting at $264 and $284 round-trip. Delta is priced at 38% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Syracuse one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $248. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Des Moines to Syracuse for a low price.

  • Can I find deals for flights from Des Moines to Syracuse that include hotel bookings?

    Yes. In addition to deals on Des Moines to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Syracuse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Syracuse.

  • Can I find deals for business class flights from Des Moines to Syracuse?

    Yes. Cheapflights offers flight deals from Des Moines to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Syracuse?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $272). Flying from Des Moines to Syracuse in July is currently the most expensive (average of $379). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Auburn
Liverpool
Cicero
East Syracuse
Waterloo

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Alternative routes for Des Moines to Syracuse

See prices for flight routes from nearby airports that may be better suited for you.
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Sioux City to Buffalo flights

Top 3 airlines flying from Des Moines to Syracuse

Discover the top 3 airlines that operate flights from Des Moines to Syracuse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$188Average$408FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$363FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$374Average$542FlexibilityNo cancel feeOn-time69%

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