HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Syracuse

$253+ Cheap flights from Des Moines to Syracuse (DSM - SYR)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/9. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SYR
jan 11 — jan 181
dom 1/11
dom 1/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Syracuse with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Syracuse

Cheapest flights from Des Moines to Syracuse
Explore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on dezembro 12, 2025.

This Delta deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 12/305:21 pmDSM - SYR
1 stop4h 56mDelta
sex 1/22:00 pmSYR - DSM
1 stop6h 29mDelta
Deal found 12/10$394
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 12/306:52 pmDSM - SYR
1 stop15h 12mAmerican Airlines
qui 1/15:26 pmSYR - DSM
1 stop8h 11mAmerican Airlines
Deal found 12/11$403
This Delta deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sex 12/265:55 pmDSM - SYR
1 stop4h 39mDelta
ter 12/306:00 amSYR - DSM
1 stop4h 49mDelta
Deal found 12/10$443
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 12/306:46 pmDSM - SYR
1 stop25h 23mUnited Airlines
qui 1/15:30 amSYR - DSM
2 stops10h 03mUnited Airlines
Deal found 12/10$468
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 12/313:14 pmDSM - SYR
1 stop4h 55mUnited Airlines
sáb 1/36:15 amSYR - DSM
1 stop5h 35mUnited Airlines
Deal found 12/11$481
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ter 12/303:14 pmDSM - SYR
1 stop4h 55mUnited Airlines
sex 1/25:45 amSYR - DSM
2 stops9h 48mUnited Airlines
Deal found 12/11$489
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb 12/278:00 amDSM - SYR
1 stop12h 09mUnited Airlines
qua 12/316:15 amSYR - DSM
1 stop5h 35mUnited Airlines
Deal found 12/11$550

Find flight deals from Des Moines to Syracuse

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Syracuse (SYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated dezembro 12, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$253
(United Airlines)

Popular in

March

Cheapest in

September

Average price

$358
Provider with most accurate pricing for Des Moines-Syracuse Hancock Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Syracuse Hancock Intl flights.
Search Deals
From Des Moines to Syracuse Hancock Intl
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($48 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($25 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated dezembro 12, 2025.
Use the filters below to find and compare flights from Des Moines to Syracuse that are best for you.

Fly from

Des Moines

Fly to

Syracuse

Route

Depart

Return

Price

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

sex 1/9

1:35 pm-11:13 pm

1 stop8h 38m

Syracuse Hancock Intl

ter 1/20

4:57 pm-9:50 pm

1 stop5h 53m

$253

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

dom 1/25

5:49 pm-11:13 pm

1 stop4h 24m

Syracuse Hancock Intl

dom 2/1

5:50 am-9:41 am

1 stop4h 51m

$299

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

dom 1/25

5:01 pm-11:54 pm

1 stop5h 53m

Syracuse Hancock Intl

dom 2/1

2:15 pm-10:11 pm

2 stops8h 56m

$305

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

qui 1/8

8:00 am-4:15 pm

1 stop7h 15m

Syracuse Hancock Intl

seg 1/12

4:57 pm-9:50 pm

1 stop5h 53m

$329

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

dom 1/25

8:00 am-4:15 pm

1 stop7h 15m

Syracuse Hancock Intl

dom 2/1

5:48 am-2:33 pm

2 stops9h 45m

$354

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Compare providers for flights from Des Moines to Syracuse

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Syracuse in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
MytripPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Syracuse flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on Des Moines-Syracuse flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from Des Moines-Syracuse flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Syracuse flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Syracuse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Syracuse

What is the cheapest month to book a flight from Des Moines to Syracuse?

Currently, May is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $213). Flying from Des Moines to Syracuse in March is currently the most expensive (average of $597). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Syracuse

Get insights into the airlines that provide service to Syracuse. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Syracuse. Reviews last updated dezembro 12, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Des Moines to Syracuse by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,007 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Syracuse?

    A quick flight from Des Moines to Syracuse can take about 4h 24m. United Airlines provides one of the quickest options available for as low as $299. Des Moines and Syracuse are separated by a distance of 901 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Syracuse round-trip?

    Our cheapest airline available from Des Moines to Syracuse is Delta. Our recent data shows that you can find tickets from as low as $236 on this airline. An additional option worth looking into is American Airlines, starting at $258. Delta is priced at 35% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Syracuse that include hotel bookings?

    Yes. In addition to deals on Des Moines to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Syracuse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Syracuse.

  • Can I find deals for business class flights from Des Moines to Syracuse?

    Yes. Cheapflights offers flight deals from Des Moines to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Syracuse?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $213). Flying from Des Moines to Syracuse in March is currently the most expensive (average of $597). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
Liverpool
East Syracuse
Waterloo

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Syracuse

See prices for flight routes from nearby airports that may be better suited for you.
Omaha to LaGuardia flights
Des Moines to LaGuardia flights
Omaha to John F Kennedy Intl flights
Des Moines to John F Kennedy Intl flights
Omaha to Newark flights
Cedar Rapids to John F Kennedy Intl flights
Des Moines to Newark flights
Cedar Rapids to LaGuardia flights
Cedar Rapids to Newark flights
Moline to John F Kennedy Intl flights
Moline to LaGuardia flights
Moline to Newark flights
Des Moines to Stewart flights
Moline to Syracuse flights
Cedar Rapids to White Plains flights
Cedar Rapids to Stewart flights
Omaha to Buffalo flights
Cedar Rapids to Buffalo flights
Des Moines to Albany flights
Omaha to Albany flights
Cedar Rapids to Syracuse flights
Omaha to Stewart flights
Des Moines to White Plains flights
Omaha to White Plains flights
Des Moines to Buffalo flights
Dubuque to Rochester flights
Omaha to Rochester flights
Sioux City to LaGuardia flights
Cedar Rapids to Albany flights
Des Moines to Ithaca flights
Cedar Rapids to Rochester flights
Sioux City to Newark flights
Moline to Buffalo flights
Des Moines to Rochester flights
Waterloo to Newark flights
La Crosse to John F Kennedy Intl flights
La Crosse to Newark flights
Waterloo to John F Kennedy Intl flights
Omaha to Syracuse flights
La Crosse to LaGuardia flights
Moline to White Plains flights
Waterloo to LaGuardia flights
Moline to Rochester flights
Moline to Albany flights
Sioux City to Buffalo flights
Sioux City to John F Kennedy Intl flights
Cedar Rapids to Ithaca flights
Omaha to Ithaca flights

Top 2 airlines flying from Des Moines to Syracuse

Discover the top 2 airlines that operate flights from Des Moines to Syracuse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated dezembro 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$236Average$328FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$356FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.