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Syracuse

$142+ Cheap flights from Des Moines to Syracuse (DSM - SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SYR
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Cheap flight deals from Des Moines to Syracuse

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Syracuse (SYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$258
(American Airlines)

One-way from

$142
(Kiwi.com)

Popular in

March

Cheapest in

September

Average price

$287
Provider with most accurate pricing for Des Moines-Syracuse Hancock Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Syracuse Hancock Intl flights.
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From Des Moines to Syracuse Hancock Intl
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One-way flight from Des Moines to Syracuse Hancock Intl
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Highest demand for flights based on searches. 9% potential increase in price ($38 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($23 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Des Moines to Syracuse

Cheapest flights from Des Moines to Syracuse
Explore the most affordable flight options available from Des Moines to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/96:00 amDSM - SYR
1 stop4h 33mAmerican Airlines
Tue 12/167:05 amSYR - DSM
1 stop8h 28mAmerican Airlines
Deal found 10/26$258
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/56:17 amDSM - SYR
1 stop4h 51mDelta
Sun 12/76:00 amSYR - DSM
1 stop4h 40mDelta
Deal found 10/27$259
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/155:35 amDSM - SYR
1 stop6h 43mDelta
Tue 11/1812:56 pmSYR - DSM
1 stop4h 23mDelta
Deal found 10/26$274
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/154:03 pmDSM - SYR
1 stop7h 16mAmerican Airlines
Tue 11/182:41 pmSYR - DSM
2 stops8h 27mAmerican Airlines
Deal found 10/27$279
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/85:45 amDSM - SYR
1 stop5h 07mAmerican Airlines
Sat 11/155:28 pmSYR - DSM
1 stop5h 42mAmerican Airlines
Deal found 10/28$326
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/263:15 pmDSM - SYR
1 stop4h 47mUnited Airlines
Sun 11/309:46 pmSYR - DSM
1 stop4h 56mUnited Airlines
Deal found 10/27$329
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:32 pmDSM - SYR
1 stop4h 52mDelta
Sun 11/96:00 amSYR - DSM
1 stop4h 41mDelta
Deal found 10/26$334
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/511:35 amDSM - SYR
2 stops10h 44mUnited Airlines
Sun 12/75:23 pmSYR - DSM
1 stop5h 14mUnited Airlines
Deal found 10/27$349
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/155:45 amDSM - SYR
2 stops9h 55mUnited Airlines
Tue 11/185:45 amSYR - DSM
2 stops7h 29mUnited Airlines
Deal found 10/28$354

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Des Moines to Syracuse that are best for you.

Fly from

Des Moines

Fly to

Syracuse

Route

Depart

Return

Price

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Tue 12/9

6:00 am-11:33 am

1 stop4h 33m

Syracuse Hancock Intl

Tue 12/16

7:05 am-2:33 pm

1 stop8h 28m

$258

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 2/18

6:20 am-12:04 pm

1 stop4h 44m

Syracuse Hancock Intl

Sat 2/21

6:00 am-9:30 am

1 stop4h 30m

$259

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Thu 1/1

3:27 pm-11:38 pm

1 stop7h 11m

Syracuse Hancock Intl

Thu 1/8

5:00 pm-9:04 pm

1 stop5h 04m

$259

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sat 11/15

5:35 am-1:18 pm

1 stop6h 43m

Syracuse Hancock Intl

Tue 11/18

12:56 pm-4:19 pm

1 stop4h 23m

$274

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sat 11/15

2:19 pm-7:36 pm

1 stop4h 17m

Syracuse Hancock Intl

Tue 11/18

3:57 pm-11:30 pm

1 stop8h 33m

$274

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Sat 11/8

5:45 am-11:52 am

1 stop5h 07m

Syracuse Hancock Intl

Sat 11/15

5:28 pm-10:10 pm

1 stop5h 42m

$326

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Thu 11/27

9:01 am-7:05 pm

1 stop9h 04m

Syracuse Hancock Intl

Sun 11/30

9:46 pm-1:42 am

1 stop4h 56m

$329

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Wed 11/26

3:15 pm-9:02 pm

1 stop4h 47m

Syracuse Hancock Intl

Sun 11/30

9:46 pm-1:42 am

1 stop4h 56m

$329

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 12/5

1:56 pm-11:10 am

1 stop20h 14m

$142

Des MoinesSyracuse

DSM - SYR

DSMSYR

Des Moines

Fri 11/7

1:35 pm-11:15 pm

1 stop8h 40m

$407

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Compare providers for flights from Des Moines to Syracuse

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Syracuse in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
MytripPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Syracuse flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on Des Moines-Syracuse flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from Des Moines-Syracuse flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Syracuse flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Syracuse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Syracuse

What is the cheapest month to book a flight from Des Moines to Syracuse?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $207). Flying from Des Moines to Syracuse in March is currently the most expensive (average of $355). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Syracuse?

Reviews of airlines servicing Syracuse

Get insights into the airlines that provide service to Syracuse. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Syracuse. Reviews last updated October 28, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Des Moines to Syracuse by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
7.9
Good
7,994 reviews
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Syracuse?

    A quick flight from Des Moines to Syracuse can take about 4h 33m. American Airlines provides one of the quickest options available for as low as $258. Des Moines and Syracuse are separated by a distance of 901 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Syracuse round-trip?

    Our cheapest airline available from Des Moines to Syracuse is Delta. Our recent data shows that you can find tickets from as low as $236 on this airline. An additional option worth looking into is American Airlines, starting at $250. Delta is priced at 35% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Syracuse that include hotel bookings?

    Yes. In addition to deals on Des Moines to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Syracuse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Syracuse.

  • Can I find deals for business class flights from Des Moines to Syracuse?

    Yes. Cheapflights offers flight deals from Des Moines to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Syracuse?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Syracuse (average of $207). Flying from Des Moines to Syracuse in March is currently the most expensive (average of $355). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
Liverpool
East Syracuse
Waterloo

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Top 2 airlines flying from Des Moines to Syracuse

Discover the top 2 airlines that operate flights from Des Moines to Syracuse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$236Average$328FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$250Average$376FlexibilityNo cancel feeOn-time71%

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