What are the cheapest airlines to fly from Mississippi to St. Louis one-way?

For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $100. Users have also found prices from $147 and $254 on Delta and United Airlines, respectively.

What are the most popular routes from Mississippi to St. Louis?

Most travelers choose Gulfport Biloxi Regional - Lambert-St Louis, Baton Rouge Ryan - Lambert-St Louis or Memphis - Lambert-St Louis when deciding on the best route from Mississippi to St. Louis.

What is the cheapest month to fly from Mississippi to St. Louis?

Due to multiple factors, expect to potentially pay more when booking in June. For low rates, November can be a great choice for travel to St. Louis. Flights to St. Louis from Mississippi in November are about $352 on average during November, but can be found for as low as $226.

What airport do you fly into for flights to St. Louis from Mississippi?

For a flight from Mississippi to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

Can I find deals for flights from Mississippi to St. Louis that include hotel bookings?

Yes. In addition to deals on Mississippi to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Mississippi to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to St. Louis.

Can I find deals for business class flights from Mississippi to St. Louis?

Yes. Cheapflights offers flight deals from Mississippi to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$100+ Flights from Mississippi to St. Louis

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Cheap flight deals from Mississippi to St. Louis

Most accurate provider	FlightHub 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$224 (American Airlines)
One-way from	$100 (American Airlines)
Popular in	June
Cheapest in	November
Average price	$365

Provider with most accurate pricing for Jackson-Evers Intl-Lambert-St Louis flight deals.

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Provider most trusted by Cheapflights users for Jackson-Evers Intl-Lambert-St Louis flights.

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From Mississippi to Lambert-St Louis

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One-way flight from Mississippi to Lambert-St Louis

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Highest demand for flights based on searches. 19% potential increase in price ($84 potential increase over avg. RT price).

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Cheapest flight prices on average. 7% potential price decrease ($25 potential savings vs. average RT price).

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Average for round-trip flights in May 2025

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Find flight deals from Mississippi to St. Louis

Cheapest flights from Mississippi to St. Louis
Explore the most affordable flight options available from Mississippi to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Thu 5/295:30 amBTR - STL

1 stop4h 24mAmerican Airlines

Sun 6/15:19 amSTL - BTR

1 stop4h 42mAmerican Airlines

Deal found 5/1

$224

Wed 5/286:05 pmGPT - STL

1 stop5h 33mDelta

Wed 6/47:05 amSTL - GPT

1 stop6h 03mDelta

Deal found 4/30

$233

Fri 6/137:03 pmBTR - STL

1 stop4h 48mDelta

Mon 6/163:42 pmSTL - BTR

1 stop6h 44mDelta

Deal found 4/30

$249

Tue 5/134:55 pmGPT - STL

1 stop5h 08mUnited Airlines

Tue 5/208:30 amSTL - GPT

1 stop7h 41mUnited Airlines

Deal found 4/29

$254

Thu 5/157:31 pmMOB - STL

1 stop4h 07mDelta

Mon 5/195:40 pmSTL - MOB

1 stop5h 27mDelta

Deal found 4/30

$254

Mon 5/265:18 pmJAN - STL

1 stop4h 57mUnited Airlines

Thu 8/710:15 amSTL - JAN

1 stop5h 46mUnited Airlines

Deal found 4/30

$255

Tue 7/2912:47 pmGPT - STL

2 stops7h 32mAmerican Airlines

Mon 8/45:30 amSTL - GPT

1 stop4h 49mAmerican Airlines

Deal found 5/1

$259

Thu 5/153:07 pmMEM - STL

1 stop18h 02mFrontier

Sat 5/178:15 pmSTL - MEM

1 stop18h 05mFrontier

Deal found 4/30

$260

Tue 6/102:48 pmMEM - STL

1 stop6h 27mUnited Airlines

Tue 6/175:00 amSTL - MEM

1 stop6h 02mUnited Airlines

Deal found 4/30

$303

Thu 5/155:05 amBTR - STL

2 stops9h 42mUnited Airlines

Mon 5/194:50 pmSTL - BTR

1 stop4h 58mUnited Airlines

Deal found 4/30

$309

Thu 5/298:52 amMEM - STL

3 stops33h 49mMultiple Airlines

Thu 6/510:10 amSTL - MEM

1 stop7h 19mMultiple Airlines

Deal found 4/30

$310

Fri 5/95:17 amMOB - STL

1 stop4h 37mAmerican Airlines

Fri 5/1610:36 amSTL - MOB

1 stop6h 29mAmerican Airlines

Deal found 4/30

$319

Best flights from Mississippi to St. Louis
Discover carefully curated flight deals from Mississippi to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 1, 2025.

Thu 5/295:30 amBTR - STL

1 stop4h 24mAmerican Airlines

Sun 6/15:19 amSTL - BTR

1 stop4h 42mAmerican Airlines

Deal found 5/1

$224

Wed 5/286:05 pmGPT - STL

1 stop5h 33mDelta

Wed 6/47:05 amSTL - GPT

1 stop6h 03mDelta

Deal found 4/30

$233

Tue 5/134:55 pmGPT - STL

1 stop5h 08mUnited Airlines

Tue 5/208:30 amSTL - GPT

1 stop7h 41mUnited Airlines

Deal found 4/29

$254

Thu 5/153:07 pmMEM - STL

1 stop18h 02mFrontier

Sat 5/178:15 pmSTL - MEM

1 stop18h 05mFrontier

Deal found 4/30

$260

Thu 5/298:52 amMEM - STL

3 stops33h 49mMultiple Airlines

Thu 6/510:10 amSTL - MEM

1 stop7h 19mMultiple Airlines

Deal found 4/30

$310

Mon 6/21:10 pmMEM - STL

2 stops7h 25mSouthwest

Thu 6/58:45 amSTL - MEM

1 stop5h 35mSouthwest

Deal found 4/29

$344

Fri 6/137:03 pmBTR - STL

1 stop4h 48mDelta

Mon 6/163:42 pmSTL - BTR

1 stop6h 44mDelta

Deal found 4/30

$249

Mon 5/265:18 pmJAN - STL

1 stop4h 57mUnited Airlines

Thu 8/710:15 amSTL - JAN

1 stop5h 46mUnited Airlines

Deal found 4/30

$255

Tue 7/2912:47 pmGPT - STL

2 stops7h 32mAmerican Airlines

Mon 8/45:30 amSTL - GPT

1 stop4h 49mAmerican Airlines

Deal found 5/1

$259

Thu 5/157:31 pmMOB - STL

1 stop4h 07mDelta

Mon 5/195:40 pmSTL - MOB

1 stop5h 27mDelta

Deal found 4/30

$254

Tue 6/102:48 pmMEM - STL

1 stop6h 27mUnited Airlines

Tue 6/175:00 amSTL - MEM

1 stop6h 02mUnited Airlines

Deal found 4/30

$303

Thu 5/155:05 amBTR - STL

2 stops9h 42mUnited Airlines

Mon 5/194:50 pmSTL - BTR

1 stop4h 58mUnited Airlines

Deal found 4/30

$309

Last-minute flights from Mississippi to St. Louis
Discover last-minute flight deals from Mississippi to St. Louis. Data last updated May 1, 2025 and is based on user searches.

Tue 5/66:00 amGPT - STL

1 stop3h 36mDelta

Sun 5/117:05 amSTL - GPT

1 stop6h 03mDelta

Deal found 4/30

$309

Tue 5/66:25 amGPT - STL

2 stops8h 30mAmerican Airlines

Sun 5/115:19 amSTL - GPT

1 stop4h 48mAmerican Airlines

Deal found 4/30

$314

Wed 5/75:15 amMEM - STL

1 stop7h 37mAmerican Airlines

Mon 5/124:52 pmSTL - MEM

1 stop4h 42mAmerican Airlines

Deal found 4/30

$511

Wed 5/79:08 pmMEM - STL

3 stops21h 33mMultiple Airlines

Mon 5/129:20 amSTL - MEM

3 stops34h 53mMultiple Airlines

Deal found 4/30

$605

Wed 5/75:27 pmBTR - STL

1 stop6h 11mDelta

Thu 5/87:05 amSTL - BTR

1 stop6h 03mDelta

Deal found 5/1

$770

Wed 5/74:32 pmBTR - STL

2 stops7h 19mAmerican Airlines

Thu 5/85:00 amSTL - BTR

2 stops7h 25mAmerican Airlines

Deal found 5/1

$780

Thu 5/86:29 pmGPT - STL

3 stops24h 12mMultiple Airlines

Sat 5/1010:10 amSTL - GPT

2 stops31h 39mMultiple Airlines

Deal found 5/1

$606

Thu 5/85:05 amBTR - STL

1 stop4h 51mUnited Airlines

Fri 5/94:50 pmSTL - BTR

1 stop15h 46mUnited Airlines

Deal found 4/30

$629

Fri 5/97:31 pmMOB - STL

1 stop4h 07mDelta

Sun 5/116:00 amSTL - MOB

1 stop6h 15mDelta

Deal found 4/30

$304

Fri 5/95:17 amMOB - STL

1 stop4h 37mAmerican Airlines

Fri 5/1610:36 amSTL - MOB

1 stop6h 29mAmerican Airlines

Deal found 4/30

$319

Fri 5/97:00 amMOB - STL

2 stops8h 47mUnited Airlines

Fri 5/164:50 pmSTL - MOB

1 stop5h 10mUnited Airlines

Deal found 4/30

$449

Fri 5/92:45 pmMEM - STL

2 stops7h 15mSouthwest

Sun 5/117:45 amSTL - MEM

1 stop6h 15mSouthwest

Deal found 4/29

$614

One-way flights from Mississippi to St. Louis
Search for one-way flight options from Mississippi to St. Louis. Find affordable one-way fares based on user searches. Data last updated May 1, 2025.

Sat 5/315:29 amGPT - STL

1 stop4h 25mAmerican Airlines

Deal found 5/1

$100

Mon 5/267:18 pmJAN - STL

1 stop4h 20mDelta

Deal found 4/30

$147

Tue 5/275:06 pmMEM - STL

1 stop5h 39mAmerican Airlines

Deal found 5/1

$171

Mon 6/912:15 pmBTR - STL

1 stop4h 24mAmerican Airlines

Deal found 5/1

$218

Sun 5/115:17 pmJAN - STL

1 stop4h 46mUnited Airlines

Deal found 4/30

$254

Sun 6/85:10 amBTR - STL

2 stops10h 20mUnited Airlines

Deal found 5/1

$260

Tue 5/277:30 amMEM - STL

2 stops26h 26mUnited Airlines

Deal found 4/30

$310

Fri 5/99:10 amMOB - STL

1 stop5h 25mDelta

Deal found 4/30

$370

Fri 5/912:45 pmMOB - STL

2 stops26h 05mUnited Airlines

Deal found 4/30

$435

Cheapflights Fare Finder

Use the filters below to find and compare flights from Mississippi to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Baton RougeSt. Louis

BTR - STL

BTRSTL

Baton Rouge Ryan

Thu 5/29

5:30 am-9:54 am

1 stop4h 24m

Lambert-St Louis

Sun 6/1

5:19 am-10:01 am

1 stop4h 42m

$224

GulfportSt. Louis

GPT - STL

GPTSTL

Gulfport Biloxi Regional

Wed 5/28

6:05 pm-11:38 pm

1 stop5h 33m

Lambert-St Louis

Wed 6/4

7:05 am-1:08 pm

1 stop6h 03m

$233

Baton RougeSt. Louis

BTR - STL

BTRSTL

Baton Rouge Ryan

Fri 6/13

7:03 pm-11:51 pm

1 stop4h 48m

Lambert-St Louis

Mon 6/16

3:42 pm-10:26 pm

1 stop6h 44m

$249

GulfportSt. Louis

GPT - STL

GPTSTL

Gulfport Biloxi Regional

Tue 5/13

4:55 pm-10:03 pm

1 stop5h 08m

Lambert-St Louis

Tue 5/20

8:30 am-4:11 pm

1 stop7h 41m

$254

MobileSt. Louis

MOB - STL

MOBSTL

Mobile

Thu 5/15

7:31 pm-11:38 pm

1 stop4h 07m

Lambert-St Louis

Mon 5/19

5:40 pm-11:07 pm

1 stop5h 27m

$254

JacksonSt. Louis

JAN - STL

JANSTL

Jackson-Evers Intl

Mon 5/26

5:18 pm-10:15 pm

1 stop4h 57m

Lambert-St Louis

Thu 8/7

10:15 am-4:01 pm

1 stop5h 46m

$255

GulfportSt. Louis

GPT - STL

GPTSTL

Gulfport Biloxi Regional

Tue 7/29

12:47 pm-8:19 pm

2 stops7h 32m

Lambert-St Louis

Mon 8/4

5:30 am-10:19 am

1 stop4h 49m

$259

MemphisSt. Louis

MEM - STL

MEMSTL

Memphis

Thu 5/15

3:07 pm-9:09 am

1 stop18h 02m

Lambert-St Louis

Sat 5/17

8:15 pm-2:20 pm

1 stop18h 05m

$260

MemphisSt. Louis

MEM - STL

MEMSTL

Memphis

Tue 6/10

2:48 pm-9:15 pm

1 stop6h 27m

Lambert-St Louis

Tue 6/17

5:00 am-11:02 am

1 stop6h 02m

$303

Baton RougeSt. Louis

BTR - STL

BTRSTL

Baton Rouge Ryan

Thu 5/15

5:05 am-2:47 pm

2 stops9h 42m

Lambert-St Louis

Mon 5/19

4:50 pm-9:48 pm

1 stop4h 58m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/1

Showing 1-10 of 29 results

Best time to book a flight from Mississippi to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Mississippi with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to St. Louis

What is the cheapest month to book a flight from Mississippi to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Mississippi to St. Louis (average of $311). Flying from Mississippi to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS to STL?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mississippi to St. Louis as you normally would.

Rainfall in St. Louis by month

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

To help decide which airline to fly from Mississippi to St. Louis, see what other customers have to say about Southwest, Delta and United Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,293 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Southwest

8.0

Very good

4,293 reviews

Southwest

8.0

Very good

4,293 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Delta

8.0

Very good

7,934 reviews

Southwest

8.0

Very good

4,293 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

United Airlines

7.4

Good

8,696 reviews

Southwest

8.0

Very good

4,293 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,293 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Frontier

6.0

Okay

3,287 reviews

Southwest

8.0

Very good

4,293 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

What airport do you fly into for flights to St. Louis from Mississippi?
For a flight from Mississippi to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.
What are the cheapest airlines to fly from Mississippi to St. Louis one-way?
For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $100. Users have also found prices from $147 and $254 on Delta and United Airlines, respectively.
What are the most popular routes from Mississippi to St. Louis?
Most travelers choose Gulfport Biloxi Regional - Lambert-St Louis, Baton Rouge Ryan - Lambert-St Louis or Memphis - Lambert-St Louis when deciding on the best route from Mississippi to St. Louis.
Can I find deals for flights from Mississippi to St. Louis that include hotel bookings?
Yes. In addition to deals on Mississippi to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Mississippi to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to St. Louis.
Can I find deals for business class flights from Mississippi to St. Louis?
Yes. Cheapflights offers flight deals from Mississippi to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Mississippi to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Mississippi to St. Louis (average of $311). Flying from Mississippi to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Fenton

Maryland Heights

Fairview Heights

Collinsville

Wentzville

Eureka

St. Peters

Festus

Glencoe

Alton

Farmington

O'Fallon

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Mississippi to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$226	Average$288	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$228	Average$351	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$317	Average$413	FlexibilityNo cancel fee	On-time69%

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$100+ Cheap flights from Mississippi to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/31. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Mississippi to St. Louis with Cheapflights

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2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Mississippi to St. Louis

Keep the following information in mind while searching for Mississippi to St. Louis flight deals. Data was last updated May 1, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Mississippi to St. Louis

Cheapest flights from Mississippi to St. LouisExplore the most affordable flight options available from Mississippi to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Explore the most affordable flight options available from Mississippi to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Mississippi to St. Louis that are best for you.

Best time to book a flight from Mississippi to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Mississippi with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to St. Louis

What is the cheapest month to book a flight from Mississippi to St. Louis?

What is the cheapest time of day to fly from MS to STL?

Find hourly flight availability from Mississippi to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

Reviews of airlines servicing St. Louis

To help decide which airline to fly from Mississippi to St. Louis, see what other customers have to say about Southwest, Delta and United Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to St. Louis from Mississippi?

What are the cheapest airlines to fly from Mississippi to St. Louis one-way?

What are the most popular routes from Mississippi to St. Louis?

Can I find deals for flights from Mississippi to St. Louis that include hotel bookings?

How can I find direct flights from Mississippi to St. Louis?

Can I find deals for business class flights from Mississippi to St. Louis?

What is the cheapest month to book a flight from Mississippi to St. Louis?

Traveling to a place near Mississippi?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Mississippi to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Mississippi to St. Louis

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Cheapest flights from Mississippi to St. Louis
Explore the most affordable flight options available from Mississippi to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.