How long is the flight from Mississippi to St. Louis?

For as low as $249, Delta can have you in St. Louis from Mississippi in 5h 12m. There are 570 mi between Mississippi and St. Louis. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What are the cheapest airlines to fly from Mississippi to St. Louis one-way?

For one-way options, check prices for United Airlines. According to our data, you can fly for as low as $129. Users have also found prices from $129 and $160 on Delta and Southwest, respectively.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the most popular routes from Mississippi to St. Louis?

Most travelers choose Baton Rouge Ryan - Lambert-St Louis, Memphis - Lambert-St Louis or Gulfport Biloxi Regional - Lambert-St Louis when deciding on the best route from Mississippi to St. Louis.

What are the most popular airlines that fly from Mississippi to St. Louis?

Before booking your flight from Mississippi to St. Louis check out the most popular airlines for this route: Delta, American Airlines or United Airlines.

What airport do you fly into for flights to St. Louis from Mississippi?

For a flight from Mississippi to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

Can I find deals for flights from Mississippi to St. Louis that include hotel bookings?

Yes. In addition to deals on Mississippi to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Mississippi to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to St. Louis.

Can I find deals for business class flights from Mississippi to St. Louis?

Yes. Cheapflights offers flight deals from Mississippi to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$127+ Cheap Flights from Mississippi to St. Louis

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Cheap flight deals from Mississippi to St. Louis

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$162 (Kiwi.com)
One-way from	$127 (Kiwi.com)
Popular in	May
Cheapest in	February
Average price	$466

Provider with most accurate pricing for Jackson-Evers Intl-Lambert-St Louis flight deals.

Search Deals

Provider most trusted by Cheapflights users for Jackson-Evers Intl-Lambert-St Louis flights.

Search Deals

From Mississippi to Lambert-St Louis

Search Deals

One-way flight from Mississippi to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 12% potential increase in price ($58 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in October 2025

Search Deals

Find flight deals from Mississippi to St. Louis

Cheapest flights from Mississippi to St. Louis
Explore the most affordable flight options available from Mississippi to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

Mon 11/108:10 pmMEM - STL

1 stop12h 57mFrontier

Sat 11/157:45 pmSTL - MEM

1 stop23h 30mFrontier

Deal found 10/14

$162

Mon 11/108:10 pmMEM - STL

1 stop12h 57mMultiple Airlines

Tue 11/117:45 pmSTL - MEM

2 stops24h 53mMultiple Airlines

Deal found 10/16

$197

Mon 11/108:10 pmMEM - STL

1 stop12h 57mMultiple Airlines

Sat 11/157:45 pmSTL - MEM

2 stops22h 46mMultiple Airlines

Deal found 10/14

$217

Sat 11/86:00 amGPT - STL

1 stop6h 35mDelta

Sat 11/156:00 amSTL - GPT

1 stop3h 49mDelta

Deal found 10/15

$249

Wed 11/125:10 pmMOB - STL

1 stop5h 12mUnited Airlines

Sat 11/154:48 pmSTL - MOB

1 stop5h 01mUnited Airlines

Deal found 10/13

$249

Thu 11/136:00 amBTR - STL

1 stop7h 00mDelta

Sat 11/156:00 amSTL - BTR

1 stop6h 29mDelta

Deal found 10/14

$249

Wed 10/296:15 amGPT - STL

1 stop5h 51mAmerican Airlines

Wed 11/57:00 amSTL - GPT

1 stop5h 37mAmerican Airlines

Deal found 10/14

$254

Fri 10/313:40 pmBTR - STL

1 stop6h 14mDelta

Tue 11/46:00 amSTL - BTR

1 stop6h 26mDelta

Deal found 10/16

$254

Thu 11/66:44 amJAN - STL

1 stop6h 29mAmerican Airlines

Thu 11/135:00 amSTL - JAN

1 stop7h 31mAmerican Airlines

Deal found 10/16

$257

Wed 10/295:15 pmGPT - STL

1 stop5h 07mUnited Airlines

Sun 11/25:15 amSTL - GPT

1 stop5h 02mUnited Airlines

Deal found 10/14

$259

Thu 10/306:59 pmMOB - STL

1 stop4h 50mAmerican Airlines

Mon 11/35:56 pmSTL - MOB

1 stop5h 09mAmerican Airlines

Deal found 10/15

$259

Sat 11/112:10 pmBTR - STL

2 stops7h 29mUnited Airlines

Wed 11/58:20 amSTL - BTR

1 stop7h 01mUnited Airlines

Deal found 10/14

$259

Best flights from Mississippi to St. Louis
Discover carefully curated flight deals from Mississippi to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 16, 2025.

Mon 11/108:10 pmMEM - STL

1 stop12h 57mMultiple Airlines

Tue 11/117:45 pmSTL - MEM

2 stops24h 53mMultiple Airlines

Deal found 10/16

$197

Sat 11/86:00 amGPT - STL

1 stop6h 35mDelta

Sat 11/156:00 amSTL - GPT

1 stop3h 49mDelta

Deal found 10/15

$249

Wed 11/125:10 pmMOB - STL

1 stop5h 12mUnited Airlines

Sat 11/154:48 pmSTL - MOB

1 stop5h 01mUnited Airlines

Deal found 10/13

$249

Sat 11/85:20 amGPT - STL

1 stop7h 17mAmerican Airlines

Sat 11/157:00 amSTL - GPT

2 stops9h 24mAmerican Airlines

Deal found 10/15

$254

Fri 12/1211:50 amJAN - STL

1 stop5h 30mSouthwest

Mon 12/157:00 amSTL - JAN

2 stops8h 05mSouthwest

Deal found 10/15

$288

Thu 11/137:12 pmMOB - STL

1 stop4h 32mDelta

Sun 11/166:00 amSTL - MOB

1 stop6h 43mDelta

Deal found 10/14

$249

Fri 10/315:07 amBTR - STL

1 stop5h 32mUnited Airlines

Mon 11/176:15 amSTL - BTR

1 stop7h 07mUnited Airlines

Deal found 10/14

$249

Wed 10/296:15 amGPT - STL

1 stop5h 51mAmerican Airlines

Wed 11/57:00 amSTL - GPT

1 stop5h 37mAmerican Airlines

Deal found 10/14

$254

Fri 11/146:00 amBTR - STL

1 stop4h 43mDelta

Sat 11/157:05 amSTL - BTR

1 stop5h 24mDelta

Deal found 10/15

$249

Thu 11/131:00 pmBTR - STL

1 stop4h 54mAmerican Airlines

Sat 11/156:00 amSTL - BTR

2 stops7h 45mAmerican Airlines

Deal found 10/14

$254

Thu 11/135:07 amBTR - STL

1 stop5h 32mUnited Airlines

Sat 11/1510:00 amSTL - BTR

2 stops9h 27mUnited Airlines

Deal found 10/15

$254

Fri 10/317:00 amMEM - STL

1 stop6h 17mMultiple Airlines

Tue 11/47:45 pmSTL - MEM

2 stops39h 43mMultiple Airlines

Deal found 10/16

$288

Fri 10/312:10 pmJAN - STL

1 stop4h 50mSouthwest

Mon 11/39:45 amSTL - JAN

1 stop7h 55mSouthwest

Deal found 10/13

$290

Thu 11/136:00 amBTR - STL

1 stop7h 00mDelta

Sat 11/156:00 amSTL - BTR

1 stop6h 29mDelta

Deal found 10/14

$249

Sat 11/19:30 amBTR - STL

1 stop6h 37mUnited Airlines

Wed 11/58:20 amSTL - BTR

1 stop5h 02mUnited Airlines

Deal found 10/14

$254

Thu 11/66:44 amJAN - STL

1 stop6h 29mAmerican Airlines

Thu 11/135:00 amSTL - JAN

1 stop7h 31mAmerican Airlines

Deal found 10/16

$257

Sat 11/13:45 pmGPT - STL

1 stop6h 19mDelta

Sat 11/156:00 amSTL - GPT

1 stop3h 49mDelta

Deal found 10/14

$254

Fri 11/142:05 pmBTR - STL

1 stop4h 42mUnited Airlines

Sat 11/1510:00 amSTL - BTR

2 stops9h 27mUnited Airlines

Deal found 10/15

$254

Fri 10/311:35 pmGPT - STL

1 stop4h 47mAmerican Airlines

Tue 11/46:00 amSTL - GPT

2 stops7h 20mAmerican Airlines

Deal found 10/16

$259

Sat 11/83:56 pmMEM - STL

2 stops17h 11mMultiple Airlines

Sat 11/157:45 pmSTL - MEM

1 stop23h 30mMultiple Airlines

Deal found 10/14

$321

Mon 11/1012:00 pmJAN - STL

1 stop6h 47mUnited Airlines

Tue 11/1111:20 amSTL - JAN

1 stop4h 45mUnited Airlines

Deal found 10/16

$257

Sat 11/112:42 pmGPT - STL

2 stops8h 11mAmerican Airlines

Sat 11/155:00 amSTL - GPT

1 stop7h 23mAmerican Airlines

Deal found 10/14

$259

Fri 10/314:35 pmMOB - STL

1 stop5h 19mDelta

Tue 11/43:59 pmSTL - MOB

1 stop6h 49mDelta

Deal found 10/16

$259

Fri 12/1211:50 amJAN - STL

2 stops7h 45mSouthwest

Sun 12/143:50 pmSTL - JAN

2 stops6h 15mSouthwest

Deal found 10/16

$347

Fri 11/712:23 pmMEM - STL

2 stops20h 44mMultiple Airlines

Sun 11/95:12 pmSTL - MEM

1 stop26h 48mMultiple Airlines

Deal found 10/14

$325

Thu 10/306:59 pmMOB - STL

1 stop4h 50mAmerican Airlines

Mon 11/35:56 pmSTL - MOB

1 stop5h 09mAmerican Airlines

Deal found 10/15

$259

Wed 2/187:15 pmMOB - STL

1 stop4h 25mDelta

Sat 2/2110:00 amSTL - MOB

1 stop6h 47mDelta

Deal found 10/13

$274

Mon 11/101:25 pmMEM - STL

1 stop4h 05mSouthwest

Tue 11/114:25 pmSTL - MEM

1 stop6h 00mSouthwest

Deal found 10/16

$366

Sat 10/255:25 pmGPT - STL

1 stop4h 33mUnited Airlines

Tue 10/2811:20 amSTL - GPT

1 stop4h 42mUnited Airlines

Deal found 10/14

$284

Wed 11/126:33 amMOB - STL

2 stops11h 05mAmerican Airlines

Sat 11/158:43 amSTL - MOB

2 stops9h 13mAmerican Airlines

Deal found 10/13

$259

Last-minute flights from Mississippi to St. Louis
Discover last-minute flight deals from Mississippi to St. Louis. Data last updated October 16, 2025 and is based on user searches.

Wed 10/296:15 amGPT - STL

1 stop5h 51mAmerican Airlines

Wed 11/56:52 amSTL - GPT

1 stop6h 28mAmerican Airlines

Deal found 10/15

$254

Wed 10/295:15 pmGPT - STL

1 stop5h 07mUnited Airlines

Sun 11/25:15 amSTL - GPT

1 stop5h 02mUnited Airlines

Deal found 10/14

$259

Thu 10/306:59 pmMOB - STL

1 stop4h 50mAmerican Airlines

Mon 11/35:56 pmSTL - MOB

1 stop5h 09mAmerican Airlines

Deal found 10/15

$259

Fri 10/313:40 pmBTR - STL

1 stop6h 14mDelta

Tue 11/46:00 amSTL - BTR

1 stop6h 26mDelta

Deal found 10/16

$254

Sat 11/112:10 pmBTR - STL

2 stops7h 29mUnited Airlines

Wed 11/58:20 amSTL - BTR

1 stop7h 01mUnited Airlines

Deal found 10/14

$259

Thu 11/66:44 amJAN - STL

1 stop6h 29mAmerican Airlines

Thu 11/135:00 amSTL - JAN

1 stop7h 31mAmerican Airlines

Deal found 10/16

$257

Sat 11/86:00 amGPT - STL

1 stop6h 35mDelta

Sat 11/156:00 amSTL - GPT

1 stop3h 49mDelta

Deal found 10/15

$249

Mon 11/108:10 pmMEM - STL

1 stop12h 57mFrontier

Sat 11/157:45 pmSTL - MEM

1 stop23h 30mFrontier

Deal found 10/14

$162

Mon 11/108:10 pmMEM - STL

1 stop12h 57mMultiple Airlines

Sat 11/157:45 pmSTL - MEM

2 stops22h 46mMultiple Airlines

Deal found 10/14

$217

Mon 11/1011:50 amJAN - STL

1 stop5h 30mSouthwest

Tue 11/116:05 amSTL - JAN

2 stops9h 00mSouthwest

Deal found 10/16

$262

Wed 11/125:10 pmMOB - STL

1 stop5h 12mUnited Airlines

Sat 11/154:48 pmSTL - MOB

1 stop5h 01mUnited Airlines

Deal found 10/13

$249

Thu 11/136:00 amBTR - STL

1 stop7h 00mDelta

Sat 11/156:00 amSTL - BTR

1 stop6h 29mDelta

Deal found 10/14

$249

One-way flights from Mississippi to St. Louis
Search for one-way flight options from Mississippi to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 16, 2025.

Fri 11/1412:23 pmMEM - STL

2 stops20h 44mMultiple Airlines

Deal found 10/15

$127

Tue 11/1112:00 pmJAN - STL

1 stop6h 47mUnited Airlines

Deal found 10/15

$129

Fri 12/57:14 pmJAN - STL

1 stop4h 26mDelta

Deal found 10/16

$155

Wed 11/1910:35 amGPT - STL

1 stop5h 32mDelta

Deal found 10/15

$160

Tue 11/116:25 amJAN - STL

2 stops8h 00mSouthwest

Deal found 10/15

$160

Wed 11/196:43 amGPT - STL

2 stops10h 04mAmerican Airlines

Deal found 10/15

$165

Mon 11/241:17 pmMEM - STL

1 stop9h 42mAmerican Airlines

Deal found 10/15

$168

Thu 11/201:25 pmMEM - STL

1 stop6h 35mSouthwest

Deal found 10/14

$169

Tue 11/2511:37 amMEM - STL

1 stop4h 50mAmerican Airlines

Deal found 10/16

$181

Tue 11/259:16 pmMEM - STL

3 stops45h 42mMultiple Airlines

Deal found 10/16

$190

Fri 11/215:48 pmMEM - STL

2 stops15h 09mMultiple Airlines

Deal found 10/15

$194

Fri 11/2110:28 amMEM - STL

1 stop23h 34mFrontier

Deal found 10/15

$197

Cheapflights Fare Finder

Use the filters below to find and compare flights from Mississippi to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MemphisSt. Louis

MEM - STL

MEMSTL

Memphis

Mon 11/10

8:10 pm-9:07 am

1 stop12h 57m

Lambert-St Louis

Tue 11/11

7:45 pm-8:38 pm

2 stops24h 53m

$197

GulfportSt. Louis

GPT - STL

GPTSTL

Gulfport Biloxi Regional

Sat 11/8

6:00 am-12:35 pm

1 stop6h 35m

Lambert-St Louis

Sat 11/15

6:00 am-9:49 am

1 stop3h 49m

$249

MobileSt. Louis

MOB - STL

MOBSTL

Mobile

Wed 11/12

5:10 pm-10:22 pm

1 stop5h 12m

Lambert-St Louis

Sat 11/15

4:48 pm-9:49 pm

1 stop5h 01m

$249

MobileSt. Louis

MOB - STL

MOBSTL

Mobile

Thu 11/13

7:12 pm-11:44 pm

1 stop4h 32m

Lambert-St Louis

Sun 11/16

6:00 am-12:43 pm

1 stop6h 43m

$249

Baton RougeSt. Louis

BTR - STL

BTRSTL

Baton Rouge Ryan

Fri 10/31

5:07 am-10:39 am

1 stop5h 32m

Lambert-St Louis

Mon 11/17

6:15 am-1:22 pm

1 stop7h 07m

$249

Baton RougeSt. Louis

BTR - STL

BTRSTL

Baton Rouge Ryan

Fri 11/14

6:00 am-10:43 am

1 stop4h 43m

Lambert-St Louis

Sat 11/15

7:05 am-12:29 pm

1 stop5h 24m

$249

Baton RougeSt. Louis

BTR - STL

BTRSTL

Baton Rouge Ryan

Thu 11/13

6:00 am-1:00 pm

1 stop7h 00m

Lambert-St Louis

Sat 11/15

6:00 am-12:29 pm

1 stop6h 29m

$249

GulfportSt. Louis

GPT - STL

GPTSTL

Gulfport Biloxi Regional

Sat 11/8

5:20 am-12:37 pm

1 stop7h 17m

Lambert-St Louis

Sat 11/15

7:00 am-4:24 pm

2 stops9h 24m

$254

GulfportSt. Louis

GPT - STL

GPTSTL

Gulfport Biloxi Regional

Wed 10/29

6:15 am-12:06 pm

1 stop5h 51m

Lambert-St Louis

Wed 11/5

7:00 am-12:37 pm

1 stop5h 37m

$254

Baton RougeSt. Louis

BTR - STL

BTRSTL

Baton Rouge Ryan

Thu 11/13

1:00 pm-5:54 pm

1 stop4h 54m

Lambert-St Louis

Sat 11/15

6:00 am-1:45 pm

2 stops7h 45m

$254

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/15

Showing 1-10 of 56 results

...

Best time to book a flight from Mississippi to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Mississippi with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to St. Louis

What is the cheapest month to book a flight from Mississippi to St. Louis?

Currently, December is the cheapest month in which you can book a flight from Mississippi to St. Louis (average of $209). Flying from Mississippi to St. Louis in March is currently the most expensive (average of $410). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS to STL?

A simple way to save on the total cost of your ticket is to fly from Mississippi to St. Louis in the afternoon. If you’re flexible enough to do this you can expect to save up to 24% on your trip compared to booking a flight at noon.

Related info for your journey

What airport do you fly into for flights to St. Louis from Mississippi?
For a flight from Mississippi to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.
How long is the flight from Mississippi to St. Louis?
For as low as $249, Delta can have you in St. Louis from Mississippi in 5h 12m. There are 570 mi between Mississippi and St. Louis. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines to fly from Mississippi to St. Louis one-way?
For one-way options, check prices for United Airlines. According to our data, you can fly for as low as $129. Users have also found prices from $129 and $160 on Delta and Southwest, respectively.
What are the most popular routes from Mississippi to St. Louis?
Most travelers choose Baton Rouge Ryan - Lambert-St Louis, Memphis - Lambert-St Louis or Gulfport Biloxi Regional - Lambert-St Louis when deciding on the best route from Mississippi to St. Louis.
Can I find deals for flights from Mississippi to St. Louis that include hotel bookings?
Yes. In addition to deals on Mississippi to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Mississippi to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to St. Louis.
Can I find deals for business class flights from Mississippi to St. Louis?
Yes. Cheapflights offers flight deals from Mississippi to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Mississippi to St. Louis?
Currently, December is the cheapest month in which you can book a flight from Mississippi to St. Louis (average of $209). Flying from Mississippi to St. Louis in March is currently the most expensive (average of $410). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Edwardsville

O'Fallon

Fairview Heights

Maryland Heights

Collinsville

Eureka

Glencoe

St. Peters

Chesterfield

Alton

Farmington

Festus

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Mississippi to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$240	Average$337	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$242	Average$325	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$317	Average$438	FlexibilityNo cancel fee	On-time69%

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$127+ Cheap flights from Mississippi to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/14. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Mississippi to St. Louis

Keep the following information in mind while searching for Mississippi to St. Louis flight deals. Data was last updated October 16, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Mississippi to St. Louis

Cheapest flights from Mississippi to St. LouisExplore the most affordable flight options available from Mississippi to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

Explore the most affordable flight options available from Mississippi to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Mississippi to St. Louis that are best for you.

Best time to book a flight from Mississippi to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Mississippi with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to St. Louis

What is the cheapest month to book a flight from Mississippi to St. Louis?

What is the cheapest time of day to fly from MS to STL?

Find hourly flight availability from Mississippi to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to St. Louis from Mississippi?

How long is the flight from Mississippi to St. Louis?

What are the cheapest airlines to fly from Mississippi to St. Louis one-way?

What are the most popular routes from Mississippi to St. Louis?

Can I find deals for flights from Mississippi to St. Louis that include hotel bookings?

How can I find direct flights from Mississippi to St. Louis?

Can I find deals for business class flights from Mississippi to St. Louis?

What is the cheapest month to book a flight from Mississippi to St. Louis?

Traveling to a place near St. Louis?

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Alternative routes for Mississippi to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Mississippi to St. Louis

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Cheapest flights from Mississippi to St. Louis
Explore the most affordable flight options available from Mississippi to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.