$207+ Cheap flights from Manchester, NH to St. Louis (MHT - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/11. Fares are subject to change and may not be available on all flights or dates of travel.
MHT — STL
Jul 15 — Jul 221
Round-trip
1 adult, Economy
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Find cheap flights from Manchester to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Manchester to St. Louis
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Best
Last-minute
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Cheapest flights from Manchester to St. LouisExplore the most affordable flight options available from Manchester to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
Explore the most affordable flight options available from Manchester to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:31 pm
MHT
- STL
1 stop5h 03m
American Airlines
Sat 8/85:05 pm
STL
- MHT
1 stop5h 14m
American Airlines
Deal found 6/10![American Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:31 pm
MHT
- STL
1 stop5h 01m
American Airlines
Wed 7/155:02 pm
STL
- MHT
1 stop5h 46m
American Airlines
Deal found 6/14![American Airlines logo]()
$333
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/143:55 pm
MHT
- STL
2 stops8h 10m
Southwest
Tue 7/215:40 am
STL
- MHT
1 stop4h 10m
Southwest
Deal found 6/13![Southwest logo]()
$338
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:20 pm
MHT
- STL
1 stop5h 22m
American Airlines
Sun 11/226:17 pm
STL
- MHT
1 stop4h 39m
American Airlines
Deal found 6/13![American Airlines logo]()
$380
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/610:20 am
MHT
- STL
2 stops5h 50m
Southwest
Sat 8/85:45 am
STL
- MHT
1 stop4h 30m
Southwest
Deal found 6/10![Southwest logo]()
$381
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/89:10 am
MHT
- STL
2 stops9h 15m
Southwest
Wed 7/155:40 am
STL
- MHT
1 stop4h 10m
Southwest
Deal found 6/14![Southwest logo]()
$383
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/284:55 pm
MHT
- STL
1 stop7h 20m
Southwest
Sat 8/15:10 am
STL
- MHT
1 stop5h 45m
Southwest
Deal found 6/11![Southwest logo]()
$387
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/181:30 pm
MHT
- STL
2 stops10h 55m
United Airlines
Sun 11/221:27 pm
STL
- MHT
2 stops9h 32m
United Airlines
Deal found 6/13![United Airlines logo]()
$390
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:40 am
MHT
- STL
1 stop6h 55m
Southwest
Sun 8/166:00 am
STL
- MHT
1 stop6h 35m
Southwest
Deal found 6/10![Southwest logo]()
$408
Best flights from Manchester to St. LouisDiscover carefully curated flight deals from Manchester to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
Discover carefully curated flight deals from Manchester to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:31 pm
MHT
- STL
1 stop5h 03m
American Airlines
Sat 8/85:05 pm
STL
- MHT
1 stop5h 14m
American Airlines
Deal found 6/10![American Airlines logo]()
$289
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/143:55 pm
MHT
- STL
2 stops8h 10m
Southwest
Tue 7/215:40 am
STL
- MHT
1 stop4h 10m
Southwest
Deal found 6/13![Southwest logo]()
$338
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/82:37 pm
MHT
- STL
2 stops10h 07m
United Airlines
Wed 7/156:00 am
STL
- MHT
2 stops12h 02m
United Airlines
Deal found 6/10![United Airlines logo]()
$427
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/610:20 am
MHT
- STL
2 stops5h 50m
Southwest
Sat 8/85:45 am
STL
- MHT
1 stop4h 30m
Southwest
Deal found 6/10![Southwest logo]()
$381
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/89:10 am
MHT
- STL
2 stops9h 15m
Southwest
Wed 7/155:40 am
STL
- MHT
1 stop4h 10m
Southwest
Deal found 6/10![Southwest logo]()
$397
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/155:45 am
MHT
- STL
1 stop6h 45m
Southwest
Wed 7/153:15 pm
STL
- MHT
2 stops6h 35m
Southwest
Deal found 6/12![Southwest logo]()
$425
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/612:55 pm
MHT
- STL
2 stops9h 05m
Southwest
Tue 11/107:40 am
STL
- MHT
2 stops8h 15m
Southwest
Deal found 6/13![Southwest logo]()
$437
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/206:05 am
MHT
- STL
2 stops8h 50m
Southwest
Fri 9/252:25 pm
STL
- MHT
1 stop6h 25m
Southwest
Deal found 6/12![Southwest logo]()
$452
Last-minute flights from Manchester to St. LouisDiscover last-minute flight deals from Manchester to St. Louis. Data last updated June 15, 2026 and is based on user searches.
Discover last-minute flight deals from Manchester to St. Louis. Data last updated June 15, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3010:27 am
MHT
- STL
1 stop7h 31m
American Airlines
Tue 7/72:32 pm
STL
- MHT
1 stop7h 58m
American Airlines
Deal found 6/12![American Airlines logo]()
$420
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:31 pm
MHT
- STL
1 stop5h 01m
American Airlines
Wed 7/155:02 pm
STL
- MHT
1 stop5h 46m
American Airlines
Deal found 6/14![American Airlines logo]()
$333
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/89:10 am
MHT
- STL
2 stops9h 15m
Southwest
Wed 7/155:40 am
STL
- MHT
1 stop4h 10m
Southwest
Deal found 6/14![Southwest logo]()
$383
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/82:37 pm
MHT
- STL
2 stops10h 07m
United Airlines
Wed 7/156:00 am
STL
- MHT
2 stops12h 02m
United Airlines
Deal found 6/14![United Airlines logo]()
$418
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/143:55 pm
MHT
- STL
2 stops8h 10m
Southwest
Tue 7/215:40 am
STL
- MHT
1 stop4h 10m
Southwest
Deal found 6/13![Southwest logo]()
$338
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/155:45 am
MHT
- STL
1 stop6h 45m
Southwest
Wed 7/151:20 pm
STL
- MHT
1 stop8h 30m
Southwest
Deal found 6/12![Southwest logo]()
$425
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/284:55 pm
MHT
- STL
1 stop7h 20m
Southwest
Sat 8/15:10 am
STL
- MHT
1 stop5h 45m
Southwest
Deal found 6/11![Southwest logo]()
$387
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/282:37 pm
MHT
- STL
2 stops9h 59m
United Airlines
Sat 8/111:25 am
STL
- MHT
2 stops11h 34m
United Airlines
Deal found 6/11![United Airlines logo]()
$409
One-way flights from Manchester to St. LouisSearch for one-way flight options from Manchester to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
Search for one-way flight options from Manchester to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1112:29 pm
MHT
- STL
3 stops45h 28m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$207
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/115:35 am
MHT
- STL
1 stop6h 05m
Southwest
Deal found 6/11![Southwest logo]()
$214
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/105:10 pm
MHT
- STL
1 stop7h 05m
Southwest
Deal found 6/11![Southwest logo]()
$224
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/304:55 pm
MHT
- STL
1 stop7h 15m
Southwest
Deal found 6/12![Southwest logo]()
$254
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/57:14 am
MHT
- STL
1 stop6h 41m
American Airlines
Deal found 6/15![American Airlines logo]()
$332
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/105:36 pm
MHT
- STL
3 stops46h 20m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$411
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/69:25 am
MHT
- STL
2 stops15h 19m
United Airlines
Deal found 6/15![United Airlines logo]()
$516
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/282:37 pm
MHT
- STL
2 stops10h 07m
United Airlines
Deal found 6/14![United Airlines logo]()
$524
Find flight deals from Manchester to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Manchester (MHT) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $289 (American Airlines) |
One-way from | $207 (Kiwi.com) |
Popular in | March |
Cheapest in | February |
Average price | $426 |
Cheapflights Fare Finder
Customize your flight search to find flights from Manchester to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from Manchester to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
ManchesterSt. Louis
MHT - STL
MHTSTL
Manchester
Thu 8/6
7:31 pm-11:34 pm
1 stop5h 03m
Lambert-St Louis
Sat 8/8
5:05 pm-11:19 pm
1 stop5h 14m
$289
ManchesterSt. Louis
MHT - STL
MHTSTL
Manchester
Tue 7/14
3:55 pm-11:05 pm
2 stops8h 10m
Lambert-St Louis
Tue 7/21
5:40 am-10:50 am
1 stop4h 10m
$338
ManchesterSt. Louis
MHT - STL
MHTSTL
Manchester
Thu 8/6
10:20 am-3:10 pm
2 stops5h 50m
Lambert-St Louis
Sat 8/8
5:45 am-11:15 am
1 stop4h 30m
$381
ManchesterSt. Louis
MHT - STL
MHTSTL
Manchester
Wed 7/8
9:10 am-5:25 pm
2 stops9h 15m
Lambert-St Louis
Wed 7/15
5:40 am-10:50 am
1 stop4h 10m
$397
ManchesterSt. Louis
MHT - STL
MHTSTL
Manchester
Wed 7/15
5:45 am-11:30 am
1 stop6h 45m
Lambert-St Louis
Wed 7/15
3:15 pm-10:50 pm
2 stops6h 35m
$425
ManchesterSt. Louis
MHT - STL
MHTSTL
Manchester
Wed 7/8
2:37 pm-11:44 pm
2 stops10h 07m
Lambert-St Louis
Wed 7/15
6:00 am-7:02 pm
2 stops12h 02m
$427
ManchesterSt. Louis
MHT - STL
MHTSTL
Manchester
Fri 11/6
12:55 pm-9:00 pm
2 stops9h 05m
Lambert-St Louis
Tue 11/10
7:40 am-4:55 pm
2 stops8h 15m
$437
ManchesterSt. Louis
MHT - STL
MHTSTL
Manchester
Sun 9/20
6:05 am-1:55 pm
2 stops8h 50m
Lambert-St Louis
Fri 9/25
2:25 pm-9:50 pm
1 stop6h 25m
$452
Cheapest one-way
ManchesterSt. Louis
MHT - STL
MHTSTL
Manchester
Sat 7/11
12:29 pm-8:57 am
3 stops45h 28m
$207
ManchesterSt. Louis
MHT - STL
MHTSTL
Manchester
Sat 7/11
5:35 am-10:40 am
1 stop6h 05m
$214
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Manchester to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Manchester to St. Louis in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Manchester, New Hampshire-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Manchester, New Hampshire-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Manchester, New Hampshire-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Manchester, New Hampshire-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Manchester, New Hampshire-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Manchester to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Manchester with our price prediction graph.
MHT-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Manchester to St. Louis
What is the cheapest month to book a flight from Manchester, New Hampshire to St. Louis?
Currently, February is the cheapest month in which you can book a flight from Manchester, New Hampshire to St. Louis (average of $345). Flying from Manchester, New Hampshire to St. Louis in March is currently the most expensive (average of $919). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Manchester, New Hampshire to St. Louis?
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated June 15, 2026.
Get a feel of what it's like to fly with Southwest and American Airlines from Manchester to St. Louis by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
7.9
Food
7.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Overall
7.9
Food
7.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Overall
7.9
Food
7.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from Manchester to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Manchester to St. Louis
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Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Manchester to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Manchester and St. Louis flights
Browse other Manchester and St. Louis flight options. Last updated on June 15, 2026.
Other flights from Manchester
Browse through other flights departing from Manchester. Flights are based on user searches made on Cheapflights and were last updated on June 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 15, 2026.
Top 2 airlines flying from Manchester to St. Louis
Discover the top 2 airlines that operate flights from Manchester to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$200 | Average$436 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$261 | Average$377 | FlexibilityNo cancel fee | On-time71% |