$98+ Cheap flights from Greenville to St. Louis (GSP - STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/7. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — STL
Oct 28 — Nov 41
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Greenville to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Greenville to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from Greenville to St. LouisExplore the most affordable flight options available from Greenville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 28, 2026.
Explore the most affordable flight options available from Greenville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 28, 2026.
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:47 pm -
1 stop6h 15m
Sat 12/52:00 pm -
1 stop5h 34m
Deal found 9/27![American Airlines logo]()
$259
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:05 am -
2 stops7h 40m
Sat 12/57:00 am -
1 stop4h 15m
Deal found 9/27![Southwest logo]()
$264
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:43 pm -
1 stop6h 36m
Wed 10/219:27 am -
1 stop4h 54m
Deal found 9/24![American Airlines logo]()
$299
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:40 am -
2 stops8h 00m
Tue 10/205:50 am -
2 stops5h 50m
Deal found 9/24![Southwest logo]()
$306
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:00 am -
1 stop4h 20m
Fri 10/231:05 pm -
1 stop5h 55m
Deal found 9/24![Southwest logo]()
$308
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:40 pm -
1 stop4h 00m
Wed 10/215:50 am -
2 stops5h 50m
Deal found 9/24![Southwest logo]()
$320
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:40 pm -
1 stop4h 00m
Wed 10/218:10 am -
1 stop3h 30m
Deal found 9/25![Southwest logo]()
$324
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/217:41 pm -
1 stop5h 14m
Mon 12/283:48 pm -
1 stop4h 49m
Deal found 9/27![Delta logo]()
$343
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:40 am -
2 stops8h 45m
Sat 10/316:10 am -
2 stops9h 15m
Deal found 9/24![Southwest logo]()
$346
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:35 pm -
1 stop4h 23m
Sun 11/85:00 am -
1 stop5h 07m
Deal found 9/25![American Airlines logo]()
$356
Best flights from Greenville to St. LouisDiscover carefully curated flight deals from Greenville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 28, 2026.
Discover carefully curated flight deals from Greenville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 28, 2026.
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/242:51 pm -
2 stops7h 46m
Sat 10/317:30 am -
1 stop4h 51m
Deal found 9/24![United Airlines logo]()
$264
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:05 am -
2 stops7h 40m
Sat 12/57:00 am -
1 stop4h 15m
Deal found 9/27![Southwest logo]()
$264
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:00 am -
1 stop4h 51m
Thu 10/157:20 pm -
1 stop14h 40m
Deal found 9/24![Delta logo]()
$461
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:37 pm -
1 stop5h 03m
Fri 10/301:08 pm -
2 stops8h 52m
Deal found 9/24![United Airlines logo]()
$392
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:05 pm -
1 stop4h 50m
Sat 11/282:45 pm -
1 stop7h 20m
Deal found 9/27![Southwest logo]()
$432
Last-minute flights from Greenville to St. LouisDiscover last-minute flight deals from Greenville to St. Louis. Data last updated September 28, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to St. Louis. Data last updated September 28, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:43 pm -
1 stop6h 36m
Wed 10/219:27 am -
1 stop4h 54m
Deal found 9/24![American Airlines logo]()
$299
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:40 pm -
1 stop4h 00m
Wed 10/215:50 am -
2 stops5h 50m
Deal found 9/24![Southwest logo]()
$320
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:43 pm -
1 stop6h 36m
Tue 10/2010:48 am -
1 stop4h 35m
Deal found 9/24![American Airlines logo]()
$259
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/172:51 pm -
2 stops7h 30m
Tue 10/208:30 am -
1 stop4h 46m
Deal found 9/24![United Airlines logo]()
$264
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:40 am -
2 stops8h 00m
Tue 10/205:50 am -
2 stops5h 50m
Deal found 9/24![Southwest logo]()
$306
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:40 pm -
1 stop4h 00m
Wed 10/218:10 am -
1 stop3h 30m
Deal found 9/25![Southwest logo]()
$324
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:00 am -
1 stop4h 20m
Fri 10/231:05 pm -
1 stop5h 55m
Deal found 9/24![Southwest logo]()
$308
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:40 am -
2 stops8h 45m
Sat 10/316:10 am -
2 stops9h 15m
Deal found 9/24![Southwest logo]()
$346
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:37 pm -
1 stop5h 03m
Fri 10/301:08 pm -
2 stops8h 52m
Deal found 9/24![United Airlines logo]()
$392
One-way flights from Greenville to St. LouisSearch for one-way flight options from Greenville to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 28, 2026.
Search for one-way flight options from Greenville to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 28, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/74:27 pm -
2 stops43h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Multiple Airlines logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2011:28 am -
2 stops31h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Multiple Airlines logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1310:44 am -
2 stops31h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Multiple Airlines logo]()
$127
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/144:00 pm -
1 stop6h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![United Airlines logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:08 pm -
2 stops24h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Multiple Airlines logo]()
$143
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:40 pm -
1 stop4h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Southwest logo]()
$158
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:40 am -
2 stops8h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Southwest logo]()
$163
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:10 pm -
2 stops5h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Southwest logo]()
$167
Find flight deals from Greenville to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $259 (American Airlines) |
One-way from | $98 (Kiwi.com) |
Popular in | January |
Cheapest in | September |
Average price | $346 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 28, 2026.
Use the filters below to find and compare flights from Greenville to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Mon 12/7
4:27 pm-11:17 am
2 stops43h 50m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$98
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Tue 10/20
6:00 am-11:22 am
1 stop6h 22m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$130
Quickest round-trip
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Mon 10/19
8:40 pm-11:40 pm
1 stop4h 00m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$130
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Mon 12/7
5:34 pm-10:59 pm
1 stop6h 25m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$130
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Wed 10/14
4:00 pm-9:09 pm
1 stop6h 09m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$130
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Wed 11/11
7:05 am-1:45 pm
2 stops7h 40m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$135
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Sat 10/17
2:51 pm-10:58 pm
2 stops9h 07m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$135
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Sat 10/17
6:40 am-1:40 pm
2 stops8h 00m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$163
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Wed 11/25
4:42 pm-10:14 pm
1 stop6h 32m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$199
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Sun 11/15
9:18 am-5:40 pm
3 stops33h 22m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$204
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Greenville to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to St. Louis in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Greenville-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Greenville-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Greenville to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Greenville with our price prediction graph.
GSP-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Greenville to St. Louis
Prices
More
What is the cheapest month to book a flight from Greenville to St. Louis?
Currently, September is the cheapest month in which you can book a flight from Greenville to St. Louis (average of $346). Flying from Greenville to St. Louis in January is currently the most expensive (average of $841). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Greenville to St. Louis?
Airfare is below average for this route at the moment.
Greenville to St. Louis flights typically cost between $364 and $454 in December.The cheapest round-trip price found within the last 5 days was $259 on American Airlines (Dec 3-Dec 5).
What’s the top layover airport for flights from Greenville to St. Louis?
Share of 1-stop round-trip flights from Greenville to St. Louis chosen by Cheapflights users in the past 12 months, using the same layover each way.
Nashville (BNA) – chosen by Cheapflights users on 80% of 1-stop itineraries from Greenville to St. Louis on Cheapflights.
What’s the cheapest layover airport for flights from Greenville to St. Louis?
Average round-trip fare for 1-stop flights from Greenville to St. Louis, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Nashville (BNA) is the most affordable 1-stop option, with an average round-trip price of $348.
What’s the fastest layover option from Greenville to St. Louis?
Shortest average travel time for 1-stop one-way flights from Greenville to St. Louis, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Nashville (BNA) have the shortest average one-way travel time for 1-stop routes: 4h 10m.
Which airport typically offers the quickest layover for flights from Greenville to St. Louis?
Average layover duration for 1-stop one-way flights from Greenville to St. Louis, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Chicago (ORD) offer the fastest connection on this route, with an average layover time of 0h 50m.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 28, 2026.
Read reviews from past customers who have flown Southwest,Delta, andAmerican Airlines from Greenville to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Related info for your journey
Find useful and relevant information for your journey from Greenville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Wentzville
Maryland Heights
Collinsville
Edwardsville
Glencoe
Chesterfield
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Greenville
Popular flights
St. Louis flight routes
Alternative routes for Greenville to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Greenville to St. Louis by cabin class
Find flights from Greenville to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Greenville and St. Louis flights
Browse other Greenville and St. Louis flight options. Last updated on September 28, 2026.
Other flights from Greenville
Browse through other flights departing from Greenville. Flights are based on user searches made on Cheapflights and were last updated on September 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 28, 2026.
Top 3 airlines flying from Greenville to St. Louis
Discover the top 3 airlines that operate flights from Greenville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$246 | Average$403 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$268 | Average$387 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$288 | Average$396 | FlexibilityNo cancel fee | On-time63% |