How long is the flight from Greenville to St. Louis?

There are many flights that can get you from Greenville to St. Louis in 8h 45m. Fly via Southwest or United Airlines to get the fastest option. Airlines will cover a distance of 523 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What are the cheapest airlines flying from Greenville to St. Louis round-trip?

According to our current data, Delta ($158), American Airlines ($286), and Southwest ($288) offers the cheapest pricing from Greenville to St. Louis. Delta is priced at 59% lower than the current average price of a flight leaving 3 months from now.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the most popular airlines that fly from Greenville to St. Louis?

Delta, American Airlines and Southwest are the most popular airlines when flying from Greenville to St. Louis.

Most accurate provider : When it comes to deals on Greenville-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Greenville-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Greenville-St. Louis flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Greenville-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Greenville to St. Louis that include hotel bookings?

Yes. In addition to deals on Greenville to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Greenville to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to St. Louis.

Can I find deals for business class flights from Greenville to St. Louis?

Yes. Cheapflights offers flight deals from Greenville to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$87+ Flights from Greenville to St. Louis

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Cheap flight deals from Greenville to St. Louis

Cheapest flights from Greenville to St. Louis
Explore the most affordable flight options available from Greenville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

Thu 12/1811:33 amGSP - STL

1 stop12h 00mMultiple Airlines

Tue 12/3010:48 amSTL - GSP

2 stops28h 07mMultiple Airlines

Deal found 12/2

$272

Sat 12/209:41 pmGSP - STL

1 stop14h 15mMultiple Airlines

Tue 12/3010:48 amSTL - GSP

2 stops28h 07mMultiple Airlines

Deal found 12/2

$275

Fri 12/128:03 pmGSP - STL

1 stop27h 30mMultiple Airlines

Mon 12/159:54 amSTL - GSP

1 stop8h 29mMultiple Airlines

Deal found 12/4

$277

Wed 12/244:40 pmGSP - STL

1 stop19h 16mMultiple Airlines

Tue 12/3010:48 amSTL - GSP

2 stops28h 07mMultiple Airlines

Deal found 12/2

$281

Thu 12/1811:33 amGSP - STL

1 stop12h 00mMultiple Airlines

Wed 12/314:27 pmSTL - GSP

1 stop17h 26mMultiple Airlines

Deal found 12/2

$288

Sat 12/209:41 pmGSP - STL

1 stop14h 15mMultiple Airlines

Wed 12/314:27 pmSTL - GSP

1 stop17h 26mMultiple Airlines

Deal found 12/2

$292

Wed 12/244:40 pmGSP - STL

1 stop19h 16mMultiple Airlines

Wed 12/314:27 pmSTL - GSP

1 stop17h 26mMultiple Airlines

Deal found 12/2

$297

Mon 12/228:43 pmGSP - STL

1 stop15h 13mMultiple Airlines

Tue 12/3010:48 amSTL - GSP

2 stops28h 07mMultiple Airlines

Deal found 12/2

$303

Best flights from Greenville to St. Louis
Discover carefully curated flight deals from Greenville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 4, 2025.

Thu 1/811:15 amGSP - STL

2 stops8h 45mSouthwest

Mon 1/1211:35 amSTL - GSP

1 stop5h 00mSouthwest

Deal found 12/1

$228

Thu 1/82:55 pmGSP - STL

2 stops9h 03mUnited Airlines

Thu 1/228:30 amSTL - GSP

1 stop4h 49mUnited Airlines

Deal found 12/4

$274

Mon 12/228:43 pmGSP - STL

1 stop15h 13mMultiple Airlines

Tue 12/3010:48 amSTL - GSP

2 stops28h 07mMultiple Airlines

Deal found 12/2

$303

Thu 2/128:30 amGSP - STL

2 stops9h 45mSouthwest

Sat 2/148:05 amSTL - GSP

2 stops11h 45mSouthwest

Deal found 12/2

$295

Sun 1/1810:51 amGSP - STL

1 stop4h 39mUnited Airlines

Thu 1/2212:44 pmSTL - GSP

1 stop5h 45mUnited Airlines

Deal found 12/2

$330

Fri 12/198:03 pmGSP - STL

1 stop27h 30mMultiple Airlines

Tue 12/3010:48 amSTL - GSP

2 stops28h 07mMultiple Airlines

Deal found 12/2

$343

Last-minute flights from Greenville to St. Louis
Discover last-minute flight deals from Greenville to St. Louis. Data last updated December 4, 2025 and is based on user searches.

Fri 12/128:03 pmGSP - STL

1 stop27h 30mMultiple Airlines

Mon 12/159:54 amSTL - GSP

1 stop8h 29mMultiple Airlines

Deal found 12/4

$277

Thu 12/1811:33 amGSP - STL

1 stop12h 00mMultiple Airlines

Tue 12/3010:48 amSTL - GSP

2 stops28h 07mMultiple Airlines

Deal found 12/2

$272

Thu 12/1811:33 amGSP - STL

1 stop12h 00mMultiple Airlines

Wed 12/314:27 pmSTL - GSP

1 stop17h 26mMultiple Airlines

Deal found 12/2

$288

Sat 12/209:41 pmGSP - STL

1 stop14h 15mMultiple Airlines

Tue 12/3010:48 amSTL - GSP

2 stops28h 07mMultiple Airlines

Deal found 12/2

$275

Sat 12/209:41 pmGSP - STL

1 stop14h 15mMultiple Airlines

Wed 12/314:27 pmSTL - GSP

1 stop17h 26mMultiple Airlines

Deal found 12/2

$292

Wed 12/244:40 pmGSP - STL

1 stop19h 16mMultiple Airlines

Tue 12/3010:48 amSTL - GSP

2 stops28h 07mMultiple Airlines

Deal found 12/2

$281

Wed 12/244:40 pmGSP - STL

1 stop19h 16mMultiple Airlines

Wed 12/314:27 pmSTL - GSP

1 stop17h 26mMultiple Airlines

Deal found 12/2

$297

Thu 1/86:05 amGSP - STL

1 stop5h 46mAmerican Airlines

Mon 1/123:54 pmSTL - GSP

1 stop6h 32mAmerican Airlines

Deal found 12/1

$223

Thu 1/811:15 amGSP - STL

2 stops8h 45mSouthwest

Mon 1/1211:35 amSTL - GSP

1 stop5h 00mSouthwest

Deal found 12/1

$228

Thu 1/82:55 pmGSP - STL

2 stops9h 03mUnited Airlines

Thu 1/228:30 amSTL - GSP

1 stop4h 49mUnited Airlines

Deal found 12/4

$274

One-way flights from Greenville to St. Louis
Search for one-way flight options from Greenville to St. Louis. Find affordable one-way fares based on user searches. Data last updated December 4, 2025.

Tue 1/66:00 amGSP - STL

1 stop4h 40mAmerican Airlines

Deal found 12/2

$87

Thu 1/158:22 amGSP - STL

1 stop3h 43mDelta

Deal found 12/2

$112

Tue 1/611:15 amGSP - STL

2 stops8h 50mSouthwest

Deal found 12/2

$113

Sat 12/209:41 pmGSP - STL

1 stop14h 15mMultiple Airlines

Deal found 12/2

$128

Sat 2/148:00 amGSP - STL

2 stops8h 15mSouthwest

Deal found 12/2

$132

Thu 1/154:43 pmGSP - STL

2 stops15h 08mMultiple Airlines

Deal found 12/2

$146

Fri 1/27:59 pmGSP - STL

1 stop4h 43mDelta

Deal found 12/2

$184

Fri 12/1910:41 amGSP - STL

2 stops12h 52mMultiple Airlines

Deal found 12/2

$191

Find flight deals from Greenville to St. Louis

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$223 (American Airlines)
One-way from	$87 (American Airlines)
Popular in	December
Cheapest in	October
Average price	$461

Provider with most accurate pricing for Greenville-Lambert-St Louis flight deals.

Search Deals

Provider most trusted by Cheapflights users for Greenville-Lambert-St Louis flights.

Search Deals

From Greenville to Lambert-St Louis

Search Deals

One-way flight from Greenville to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 8% potential increase in price ($34 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Greenville to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Thu 1/8

11:15 am-7:00 pm

2 stops8h 45m

Lambert-St Louis

Mon 1/12

11:35 am-5:35 pm

1 stop5h 00m

$228

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Thu 1/8

2:55 pm-10:58 pm

2 stops9h 03m

Lambert-St Louis

Thu 1/22

8:30 am-2:19 pm

1 stop4h 49m

$274

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Thu 2/12

8:30 am-5:15 pm

2 stops9h 45m

Lambert-St Louis

Sat 2/14

8:05 am-8:50 pm

2 stops11h 45m

$295

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Mon 12/22

8:43 pm-10:56 am

1 stop15h 13m

Lambert-St Louis

Tue 12/30

10:48 am-3:55 pm

2 stops28h 07m

$303

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Sun 1/18

10:51 am-2:30 pm

1 stop4h 39m

Lambert-St Louis

Thu 1/22

12:44 pm-7:29 pm

1 stop5h 45m

$330

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Fri 12/19

8:03 pm-10:33 pm

1 stop27h 30m

Lambert-St Louis

Tue 12/30

10:48 am-3:55 pm

2 stops28h 07m

$343

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Tue 1/6

6:00 am-9:40 am

1 stop4h 40m

$87

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Sat 2/14

6:30 am-10:36 am

1 stop5h 06m

$112

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Thu 1/15

8:22 am-11:05 am

1 stop3h 43m

$112

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Tue 1/6

11:15 am-7:05 pm

2 stops8h 50m

$113

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/2

Showing 1-10 of 15 results

Compare providers for flights from Greenville to St. Louis

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to St. Louis in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Greenville-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Greenville-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Greenville-St. Louis flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Greenville-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Greenville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to St. Louis

What is the cheapest month to book a flight from Greenville to St. Louis?

Currently, June is the cheapest month in which you can book a flight from Greenville to St. Louis (average of $108). Flying from Greenville to St. Louis in March is currently the most expensive (average of $224). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to STL?

When flying from Greenville to St. Louis, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 16% versus a flight in the evening.

Reviews of airlines servicing St. Louis

Read reviews from past customers who have flown Southwest, Delta, and American Airlines from Greenville to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Southwest

8.0

Very good

4,250 reviews

Southwest

8.0

Very good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Delta

7.9

Good

8,011 reviews

Southwest

8.0

Very good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

American Airlines

7.2

Good

11,047 reviews

Southwest

8.0

Very good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

How long is the flight from Greenville to St. Louis?
There are many flights that can get you from Greenville to St. Louis in 8h 45m. Fly via Southwest or United Airlines to get the fastest option. Airlines will cover a distance of 523 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines flying from Greenville to St. Louis round-trip?
According to our current data, Delta ($158), American Airlines ($286), and Southwest ($288) offers the cheapest pricing from Greenville to St. Louis. Delta is priced at 59% lower than the current average price of a flight leaving 3 months from now.
Can I find deals for flights from Greenville to St. Louis that include hotel bookings?
Yes. In addition to deals on Greenville to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Greenville to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to St. Louis.
Can I find deals for business class flights from Greenville to St. Louis?
Yes. Cheapflights offers flight deals from Greenville to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Greenville to St. Louis?
Currently, June is the cheapest month in which you can book a flight from Greenville to St. Louis (average of $108). Flying from Greenville to St. Louis in March is currently the most expensive (average of $224). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Other flights to St. Louis

Top 3 airlines flying from Greenville to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$236	Average$379	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$286	Average$425	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$288	Average$466	FlexibilityNo cancel fee	On-time63%

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$87+ Cheap flights from Greenville to St. Louis (GSP - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/6. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Greenville to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Greenville to St. Louis

Cheapest flights from Greenville to St. LouisExplore the most affordable flight options available from Greenville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

Explore the most affordable flight options available from Greenville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

Find flight deals from Greenville to St. Louis

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Greenville to St. Louis that are best for you.

Compare providers for flights from Greenville to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to St. Louis in December.

Best time to book a flight from Greenville to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Greenville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Greenville to St. Louis

What is the cheapest month to book a flight from Greenville to St. Louis?

What is the cheapest time of day to fly from GSP to STL?

Reviews of airlines servicing St. Louis

Read reviews from past customers who have flown Southwest, Delta, and American Airlines from Greenville to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Greenville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Greenville to St. Louis?

What are the cheapest airlines flying from Greenville to St. Louis round-trip?

Can I find deals for flights from Greenville to St. Louis that include hotel bookings?

How can I find direct flights from Greenville to St. Louis?

Can I find deals for business class flights from Greenville to St. Louis?

What is the cheapest month to book a flight from Greenville to St. Louis?

Traveling to a place near St. Louis?

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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Greenville to St. Louis

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Top 3 airlines flying from Greenville to St. Louis

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Cheapest flights from Greenville to St. Louis
Explore the most affordable flight options available from Greenville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.