$182+ Cheap flights from Greenville to St. Louis (GSP - STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/10. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — STL
Dec 10 — Dec 171
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Greenville to St. Louis
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Cheapest flights from Greenville to St. LouisExplore the most affordable flight options available from Greenville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 10, 2026.
Explore the most affordable flight options available from Greenville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 10, 2026.
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:47 pm -
1 stop6h 15m
Sat 12/126:02 am -
1 stop4h 04m
Deal found 11/6![American Airlines logo]()
$333
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:30 am -
1 stop5h 00m
Sat 12/125:15 am -
2 stops8h 09m
Deal found 11/6![United Airlines logo]()
$338
This Southwest deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/512:50 pm -
2 stops8h 15m
Sat 12/125:30 am -
2 stops9h 30m
Deal found 11/6![Southwest logo]()
$343
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/146:30 am -
1 stop6h 52m
Wed 12/169:40 am -
1 stop6h 13m
Deal found 11/5![United Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:40 am -
1 stop6h 35m
Tue 12/12:33 pm -
1 stop4h 23m
Deal found 11/5![Delta logo]()
$393
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:00 am -
1 stop5h 29m
Sun 12/67:18 pm -
1 stop3h 29m
Deal found 11/10![Delta logo]()
$395
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:17 pm -
1 stop7h 17m
Sun 12/206:57 am -
1 stop6h 51m
Deal found 11/8![American Airlines logo]()
$405
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/218:32 pm -
1 stop29h 09m
Mon 12/286:21 pm -
2 stops18h 58m
Deal found 11/6![Multiple Airlines logo]()
$423
This Southwest deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:40 am -
2 stops9h 35m
Wed 12/27:35 am -
1 stop5h 35m
Deal found 11/7![Southwest logo]()
$435
Best flights from Greenville to St. LouisDiscover carefully curated flight deals from Greenville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 10, 2026.
Discover carefully curated flight deals from Greenville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 10, 2026.
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/235:37 am -
1 stop6h 23m
Tue 2/234:40 pm -
1 stop6h 18m
Deal found 11/8![Delta logo]()
$333
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:30 am -
1 stop5h 00m
Sat 12/125:15 am -
2 stops8h 09m
Deal found 11/6![United Airlines logo]()
$338
This Southwest deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/237:15 am -
2 stops7h 05m
Tue 2/234:00 pm -
1 stop4h 00m
Deal found 11/8![Southwest logo]()
$338
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:17 pm -
1 stop7h 17m
Sun 12/206:57 am -
1 stop6h 51m
Deal found 11/9![American Airlines logo]()
$405
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1412:15 pm -
2 stops11h 44m
Wed 12/161:18 pm -
2 stops9h 22m
Deal found 11/5![United Airlines logo]()
$370
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/111:10 am -
2 stops7h 55m
Mon 2/810:15 am -
2 stops8h 10m
Deal found 11/9![Southwest logo]()
$373
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:40 am -
1 stop6h 35m
Tue 12/12:33 pm -
1 stop4h 23m
Deal found 11/5![Delta logo]()
$393
This Southwest deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/296:50 am -
2 stops8h 15m
Sun 5/27:00 am -
1 stop4h 10m
Deal found 11/6![Southwest logo]()
$432
This Southwest deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:40 am -
2 stops9h 35m
Wed 12/210:30 am -
2 stops8h 25m
Deal found 11/7![Southwest logo]()
$441
This Southwest deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/66:40 am -
2 stops8h 25m
Sun 12/131:25 pm -
2 stops8h 35m
Deal found 11/8![Southwest logo]()
$447
Last-minute flights from Greenville to St. LouisDiscover last-minute flight deals from Greenville to St. Louis. Data last updated November 10, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to St. Louis. Data last updated November 10, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:40 am -
1 stop6h 35m
Tue 12/12:33 pm -
1 stop4h 23m
Deal found 11/5![Delta logo]()
$393
This Southwest deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:40 am -
2 stops9h 35m
Wed 12/27:35 am -
1 stop5h 35m
Deal found 11/7![Southwest logo]()
$435
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:00 am -
1 stop5h 29m
Sun 12/67:18 pm -
1 stop3h 29m
Deal found 11/10![Delta logo]()
$395
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:47 pm -
1 stop6h 15m
Sat 12/126:02 am -
1 stop4h 04m
Deal found 11/6![American Airlines logo]()
$333
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:30 am -
1 stop5h 00m
Sat 12/125:15 am -
2 stops8h 09m
Deal found 11/6![United Airlines logo]()
$338
This Southwest deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/512:50 pm -
2 stops8h 15m
Sat 12/125:30 am -
2 stops9h 30m
Deal found 11/6![Southwest logo]()
$343
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:17 pm -
1 stop7h 17m
Sun 12/206:57 am -
1 stop6h 51m
Deal found 11/8![American Airlines logo]()
$405
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/146:30 am -
1 stop6h 52m
Wed 12/169:40 am -
1 stop6h 13m
Deal found 11/5![United Airlines logo]()
$359
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/218:32 pm -
1 stop29h 09m
Mon 12/286:21 pm -
2 stops18h 58m
Deal found 11/6![Multiple Airlines logo]()
$423
One-way flights from Greenville to St. LouisSearch for one-way flight options from Greenville to St. Louis. Find affordable one-way fares based on user searches. Data last updated November 10, 2026.
Search for one-way flight options from Greenville to St. Louis. Find affordable one-way fares based on user searches. Data last updated November 10, 2026.
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:25 pm -
1 stop5h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Delta logo]()
$182
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:05 am -
2 stops7h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Southwest logo]()
$187
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:32 pm -
2 stops36h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/6![Multiple Airlines logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/104:02 pm -
3 stops43h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$263
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/203:28 pm -
1 stop7h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/6![American Airlines logo]()
$264
This Southwest deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2510:35 am -
2 stops6h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/10![Southwest logo]()
$269
This Southwest deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:15 am -
2 stops11h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/10![Southwest logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2512:44 pm -
3 stops36h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/10![Multiple Airlines logo]()
$414
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:53 am -
3 stops16h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/10![Multiple Airlines logo]()
$556
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:04 pm -
3 stops28h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/10![Multiple Airlines logo]()
$584
Find flight deals from Greenville to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $313 (American Airlines) |
One-way from | $182 (Delta) |
Popular in | January |
Cheapest in | September |
Average price | $384 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 10, 2026.
Use the filters below to find and compare flights from Greenville to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Thu 12/10
7:25 pm-12:05 am
1 stop5h 40m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$182
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Thu 12/10
7:05 am-1:50 pm
2 stops7h 45m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$187
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Fri 11/20
8:32 pm-7:54 am
2 stops36h 22m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$258
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Thu 12/10
4:02 pm-10:57 am
3 stops43h 55m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$263
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Tue 2/23
5:37 am-11:00 am
1 stop6h 23m
Lambert-St Louis
Tue 2/23
4:40 pm-11:58 pm
1 stop6h 18m
$333
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Sat 12/5
6:30 am-10:30 am
1 stop5h 00m
Lambert-St Louis
Sat 12/12
5:15 am-2:24 pm
2 stops8h 09m
$338
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Tue 2/23
7:15 am-1:20 pm
2 stops7h 05m
Lambert-St Louis
Tue 2/23
4:00 pm-9:00 pm
1 stop4h 00m
$338
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Mon 12/14
12:15 pm-10:59 pm
2 stops11h 44m
Lambert-St Louis
Wed 12/16
1:18 pm-11:40 pm
2 stops9h 22m
$370
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Mon 2/1
11:10 am-6:05 pm
2 stops7h 55m
Lambert-St Louis
Mon 2/8
10:15 am-7:25 pm
2 stops8h 10m
$373
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Wed 11/25
5:40 am-11:15 am
1 stop6h 35m
Lambert-St Louis
Tue 12/1
2:33 pm-7:56 pm
1 stop4h 23m
$393
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Greenville to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to St. Louis in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Greenville-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Greenville-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Greenville to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Greenville with our price prediction graph.
GSP-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Greenville to St. Louis
Prices
More
What is the cheapest month to book a flight from Greenville to St. Louis?
Currently, September is the cheapest month in which you can book a flight from Greenville to St. Louis (average of $346). Flying from Greenville to St. Louis in January is currently the most expensive (average of $841). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Greenville to St. Louis?
Airfare is typical for this route at the moment.
Greenville to St. Louis flights typically cost between $275 and $488 in December.The cheapest round-trip price found within the last 5 days was $313 on American Airlines (Dec 11-Dec 20).
What’s the top layover airport for flights from Greenville to St. Louis?
Share of 1-stop round-trip flights from Greenville to St. Louis chosen by Cheapflights users in the past 12 months, using the same layover each way.
Nashville (BNA) – chosen by Cheapflights users on 80% of 1-stop itineraries from Greenville to St. Louis on Cheapflights.
What’s the cheapest layover airport for flights from Greenville to St. Louis?
Average round-trip fare for 1-stop flights from Greenville to St. Louis, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Nashville (BNA) is the most affordable 1-stop option, with an average round-trip price of $348.
What’s the fastest layover option from Greenville to St. Louis?
Shortest average travel time for 1-stop one-way flights from Greenville to St. Louis, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Nashville (BNA) have the shortest average one-way travel time for 1-stop routes: 4h 10m.
Which airport typically offers the quickest layover for flights from Greenville to St. Louis?
Average layover duration for 1-stop one-way flights from Greenville to St. Louis, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Chicago (ORD) offer the fastest connection on this route, with an average layover time of 0h 50m.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated November 10, 2026.
Read reviews from past customers who have flown Southwest,Delta, andAmerican Airlines from Greenville to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Entertainment
7.4
Overall
8.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Food
7.0
Entertainment
7.4
Overall
8.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Food
7.0
Entertainment
7.4
Overall
8.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Food
7.0
Entertainment
7.4
Overall
8.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Related info for your journey
Find useful and relevant information for your journey from Greenville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Eureka
Wentzville
Maryland Heights
Chesterfield
Swansea
Edwardsville
Glencoe
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Greenville and St. Louis flights
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| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$396 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$266 | Average$367 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$268 | Average$398 | FlexibilityNo cancel fee | On-time71% |