$247+ Cheap flights from Greenville to St. Louis (GSP - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/23. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — STL
Aug 7 — Aug 141
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Greenville to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Greenville to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from Greenville to St. LouisExplore the most affordable flight options available from Greenville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 8, 2026.
Explore the most affordable flight options available from Greenville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 8, 2026.
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:11 pm
GSP
- STL
1 stop5h 17m
American Airlines
Mon 8/103:25 pm
STL
- GSP
1 stop5h 25m
American Airlines
Deal found 7/8![American Airlines logo]()
$249
This Southwest deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:30 pm
GSP
- STL
1 stop5h 40m
Southwest
Tue 8/117:15 am
STL
- GSP
1 stop4h 10m
Southwest
Deal found 7/7![Southwest logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/148:45 pm
GSP
- STL
1 stop28h 14m
Multiple Airlines
Fri 8/216:17 pm
STL
- GSP
2 stops36h 40m
Multiple Airlines
Deal found 7/4![Multiple Airlines logo]()
$280
This Southwest deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:00 am
GSP
- STL
1 stop4h 10m
Southwest
Mon 8/313:45 pm
STL
- GSP
1 stop4h 50m
Southwest
Deal found 7/3![Southwest logo]()
$289
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:23 pm
GSP
- STL
1 stop7h 04m
American Airlines
Sun 10/45:15 am
STL
- GSP
1 stop4h 16m
American Airlines
Deal found 7/7![American Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:06 pm
GSP
- STL
2 stops30h 31m
Multiple Airlines
Thu 8/134:09 pm
STL
- GSP
1 stop22h 51m
Multiple Airlines
Deal found 7/6![Multiple Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/11:05 pm
GSP
- STL
2 stops8h 50m
Southwest
Sun 10/41:00 pm
STL
- GSP
1 stop7h 30m
Southwest
Deal found 7/7![Southwest logo]()
$325
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:30 pm
GSP
- STL
1 stop5h 28m
American Airlines
Tue 8/49:25 am
STL
- GSP
1 stop5h 17m
American Airlines
Deal found 7/8![American Airlines logo]()
$328
Best flights from Greenville to St. LouisDiscover carefully curated flight deals from Greenville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 8, 2026.
Discover carefully curated flight deals from Greenville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 8, 2026.
This Southwest deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:30 pm
GSP
- STL
1 stop5h 40m
Southwest
Tue 8/117:15 am
STL
- GSP
1 stop4h 10m
Southwest
Deal found 7/7![Southwest logo]()
$257
This United Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/64:00 pm
GSP
- STL
1 stop6h 09m
United Airlines
Wed 10/78:00 am
STL
- GSP
1 stop4h 35m
United Airlines
Deal found 7/7![United Airlines logo]()
$337
This Delta deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:40 am
GSP
- STL
1 stop3h 32m
Delta
Sun 11/294:40 pm
STL
- GSP
1 stop5h 57m
Delta
Deal found 7/3![Delta logo]()
$355
This American Airlines deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:00 am
GSP
- STL
1 stop6h 15m
American Airlines
Sat 8/155:00 am
STL
- GSP
1 stop5h 00m
American Airlines
Deal found 7/5![American Airlines logo]()
$382
This Southwest deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:40 pm
GSP
- STL
1 stop6h 00m
Southwest
Mon 8/3112:55 pm
STL
- GSP
2 stops7h 40m
Southwest
Deal found 7/3![Southwest logo]()
$294
This Southwest deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/311:55 pm
GSP
- STL
2 stops7h 55m
Southwest
Tue 8/41:40 pm
STL
- GSP
1 stop4h 45m
Southwest
Deal found 7/8![Southwest logo]()
$333
This Southwest deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:45 am
GSP
- STL
1 stop5h 10m
Southwest
Mon 10/126:45 am
STL
- GSP
1 stop5h 50m
Southwest
Deal found 7/4![Southwest logo]()
$384
This Southwest deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/811:05 am
GSP
- STL
2 stops6h 45m
Southwest
Sat 8/1511:15 am
STL
- GSP
1 stop6h 45m
Southwest
Deal found 7/6![Southwest logo]()
$386
Last-minute flights from Greenville to St. LouisDiscover last-minute flight deals from Greenville to St. Louis. Data last updated July 8, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to St. Louis. Data last updated July 8, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:30 pm
GSP
- STL
1 stop5h 28m
American Airlines
Tue 8/49:25 am
STL
- GSP
1 stop5h 17m
American Airlines
Deal found 7/8![American Airlines logo]()
$328
This Southwest deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/311:55 pm
GSP
- STL
2 stops7h 55m
Southwest
Tue 8/41:40 pm
STL
- GSP
1 stop4h 45m
Southwest
Deal found 7/8![Southwest logo]()
$333
This Kiwi.com deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:06 pm
GSP
- STL
2 stops30h 31m
Multiple Airlines
Thu 8/134:09 pm
STL
- GSP
1 stop22h 51m
Multiple Airlines
Deal found 7/6![Multiple Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:30 pm
GSP
- STL
1 stop5h 40m
Southwest
Tue 8/117:15 am
STL
- GSP
1 stop4h 10m
Southwest
Deal found 7/7![Southwest logo]()
$257
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:11 pm
GSP
- STL
1 stop5h 17m
American Airlines
Mon 8/103:25 pm
STL
- GSP
1 stop5h 25m
American Airlines
Deal found 7/8![American Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/148:45 pm
GSP
- STL
1 stop28h 14m
Multiple Airlines
Fri 8/216:17 pm
STL
- GSP
2 stops36h 40m
Multiple Airlines
Deal found 7/4![Multiple Airlines logo]()
$280
This Southwest deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:00 am
GSP
- STL
1 stop4h 10m
Southwest
Mon 8/313:45 pm
STL
- GSP
1 stop4h 50m
Southwest
Deal found 7/3![Southwest logo]()
$289
This Delta deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/311:28 pm
GSP
- STL
1 stop5h 25m
Delta
Thu 9/312:52 pm
STL
- GSP
1 stop4h 53m
Delta
Deal found 7/7![Delta logo]()
$335
One-way flights from Greenville to St. LouisSearch for one-way flight options from Greenville to St. Louis. Find affordable one-way fares based on user searches. Data last updated July 8, 2026.
Search for one-way flight options from Greenville to St. Louis. Find affordable one-way fares based on user searches. Data last updated July 8, 2026.
This Delta deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/235:44 am
GSP
- STL
1 stop4h 59m
Delta
Deal found 7/3![Delta logo]()
$247
This United Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/232:55 pm
GSP
- STL
2 stops9h 49m
United Airlines
Deal found 7/3![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1412:50 pm
GSP
- STL
1 stop5h 35m
Southwest
Deal found 7/7![Southwest logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:07 am
GSP
- STL
3 stops22h 50m
Multiple Airlines
Deal found 7/7![Multiple Airlines logo]()
$516
Find flight deals from Greenville to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $257 (Southwest) |
One-way from | $247 (Delta) |
Popular in | January |
Cheapest in | October |
Average price | $481 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 8, 2026.
Use the filters below to find and compare flights from Greenville to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Tue 8/4
5:30 pm-10:10 pm
1 stop5h 40m
Lambert-St Louis
Tue 8/11
7:15 am-12:25 pm
1 stop4h 10m
$257
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Thu 8/20
4:40 pm-9:40 pm
1 stop6h 00m
Lambert-St Louis
Mon 8/31
12:55 pm-9:35 pm
2 stops7h 40m
$294
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Fri 7/31
1:55 pm-8:50 pm
2 stops7h 55m
Lambert-St Louis
Tue 8/4
1:40 pm-7:25 pm
1 stop4h 45m
$333
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Tue 10/6
4:00 pm-9:09 pm
1 stop6h 09m
Lambert-St Louis
Wed 10/7
8:00 am-1:35 pm
1 stop4h 35m
$337
Quickest round-trip
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Thu 11/26
5:40 am-8:12 am
1 stop3h 32m
Lambert-St Louis
Sun 11/29
4:40 pm-11:37 pm
1 stop5h 57m
$355
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Sat 8/8
7:00 am-12:15 pm
1 stop6h 15m
Lambert-St Louis
Sat 8/15
5:00 am-11:00 am
1 stop5h 00m
$382
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Wed 10/7
10:45 am-2:55 pm
1 stop5h 10m
Lambert-St Louis
Mon 10/12
6:45 am-1:35 pm
1 stop5h 50m
$384
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Sat 8/8
11:05 am-4:50 pm
2 stops6h 45m
Lambert-St Louis
Sat 8/15
11:15 am-7:00 pm
1 stop6h 45m
$386
Cheapest one-way
Quickest one-way
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Thu 7/23
5:44 am-9:43 am
1 stop4h 59m
$247
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Thu 7/23
2:55 pm-11:44 pm
2 stops9h 49m
$279
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Greenville to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to St. Louis in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Greenville-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Greenville-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Greenville to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Greenville with our price prediction graph.
GSP-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Greenville to St. Louis
Prices
More
What is the cheapest month to book a flight from Greenville to St. Louis?
Currently, October is the cheapest month in which you can book a flight from Greenville to St. Louis (average of $286). Flying from Greenville to St. Louis in January is currently the most expensive (average of $841). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Greenville to St. Louis?
What’s the top layover airport for flights from Greenville to St. Louis?
Share of 1-stop round-trip flights from Greenville to St. Louis chosen by Cheapflights users in the past 12 months, using the same layover each way.
Nashville (BNA) – chosen by Cheapflights users on 80% of 1-stop itineraries from Greenville to St. Louis on Cheapflights.
What’s the cheapest layover airport for flights from Greenville to St. Louis?
Average round-trip fare for 1-stop flights from Greenville to St. Louis, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Nashville (BNA) is the most affordable 1-stop option, with an average round-trip price of $348.
What’s the fastest layover option from Greenville to St. Louis?
Shortest average travel time for 1-stop one-way flights from Greenville to St. Louis, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Nashville (BNA) have the shortest average one-way travel time for 1-stop routes: 4h 10m.
Which airport typically offers the quickest layover for flights from Greenville to St. Louis?
Average layover duration for 1-stop one-way flights from Greenville to St. Louis, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Chicago (ORD) offer the fastest connection on this route, with an average layover time of 0h 50m.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated July 8, 2026.
Read reviews from past customers who have flown Southwest,Delta, andAmerican Airlines from Greenville to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Greenville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Greenville
Popular flights
St. Louis flight routes
Alternative routes for Greenville to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Greenville to St. Louis by cabin class
Find flights from Greenville to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Greenville and St. Louis flights
Browse other Greenville and St. Louis flight options. Last updated on July 8, 2026.
Other flights from Greenville
Browse through other flights departing from Greenville. Flights are based on user searches made on Cheapflights and were last updated on July 8, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 8, 2026.
Top 3 airlines flying from Greenville to St. Louis
Discover the top 3 airlines that operate flights from Greenville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$208 | Average$397 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$288 | Average$368 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$302 | Average$486 | FlexibilityNo cancel fee | On-time71% |