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$137+ Cheap flights from Greenville to St. Louis (GSP - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/10. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — STL
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Greenville to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2025.

Round-trip from

$270
(American Airlines)

One-way from

$137
(Kiwi.com)

Popular in

September

Cheapest in

October

Average price

$426
From Greenville to Lambert-St Louis
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One-way flight from Greenville to Lambert-St Louis
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High demand for flights, 9% potential price rise
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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Greenville to St. Louis

Cheapest flights from Greenville to St. Louis
Explore the most affordable flight options available from Greenville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/148:04 pmGSP - STL
1 stop4h 50mAmerican Airlines
Tue 10/218:42 amSTL - GSP
1 stop9h 52mAmerican Airlines
Deal found 9/16$270
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1410:04 amGSP - STL
1 stop5h 39mDelta
Wed 10/157:05 amSTL - GSP
1 stop4h 45mDelta
Deal found 9/16$277
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2110:04 amGSP - STL
1 stop5h 39mDelta
Sat 10/256:00 amSTL - GSP
1 stop3h 09mDelta
Deal found 9/14$287
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/134:46 pmGSP - STL
1 stop8h 10mAmerican Airlines
Mon 10/204:25 pmSTL - GSP
1 stop6h 26mAmerican Airlines
Deal found 9/15$297
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/56:35 amGSP - STL
1 stop4h 51mDelta
Fri 11/75:15 pmSTL - GSP
1 stop5h 40mDelta
Deal found 9/15$298
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:05 pmGSP - STL
1 stop6h 52mUnited Airlines
Sat 10/186:30 amSTL - GSP
1 stop6h 06mUnited Airlines
Deal found 9/15$303
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/67:52 amGSP - STL
1 stop5h 43mDelta
Fri 11/75:15 pmSTL - GSP
1 stop5h 40mDelta
Deal found 9/15$308
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/226:05 amGSP - STL
1 stop6h 40mSouthwest
Sun 10/267:00 amSTL - GSP
1 stop5h 10mSouthwest
Deal found 9/14$322
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/138:03 pmGSP - STL
2 stops38h 04mMultiple Airlines
Mon 10/206:05 pmSTL - GSP
1 stop20h 23mMultiple Airlines
Deal found 9/15$324
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/145:00 pmGSP - STL
1 stop6h 00mUnited Airlines
Tue 10/211:05 pmSTL - GSP
2 stops9h 10mUnited Airlines
Deal found 9/16$325

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Greenville to St. Louis that are best for you.

Fly from

Greenville

Fly to

St. Louis

Route

Depart

Return

Price

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Tue 10/14

8:04 pm-11:54 pm

1 stop4h 50m

Lambert-St Louis

Tue 10/21

8:42 am-7:34 pm

1 stop9h 52m

$270

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Tue 10/14

10:04 am-2:43 pm

1 stop5h 39m

Lambert-St Louis

Wed 10/15

7:05 am-12:50 pm

1 stop4h 45m

$277

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Wed 10/22

7:52 am-10:26 am

1 stop3h 34m

Lambert-St Louis

Mon 10/27

5:15 pm-10:18 pm

1 stop4h 03m

$287

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Tue 10/21

10:04 am-2:43 pm

1 stop5h 39m

Lambert-St Louis

Sat 10/25

6:00 am-10:09 am

1 stop3h 09m

$287

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Wed 11/5

6:35 am-10:26 am

1 stop4h 51m

Lambert-St Louis

Fri 11/7

5:15 pm-11:55 pm

1 stop5h 40m

$298

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Fri 10/17

6:05 pm-11:57 pm

1 stop6h 52m

Lambert-St Louis

Sat 10/18

6:30 am-1:36 pm

1 stop6h 06m

$303

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Thu 11/6

5:15 am-8:27 am

1 stop4h 12m

Lambert-St Louis

Fri 11/7

1:50 pm-10:31 pm

1 stop7h 41m

$308

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Thu 11/6

7:52 am-12:35 pm

1 stop5h 43m

Lambert-St Louis

Fri 11/7

5:15 pm-11:55 pm

1 stop5h 40m

$308

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Wed 10/22

6:05 am-11:45 am

1 stop6h 40m

Lambert-St Louis

Sun 10/26

7:00 am-1:10 pm

1 stop5h 10m

$322

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Tue 10/14

5:00 pm-10:00 pm

1 stop6h 00m

Lambert-St Louis

Tue 10/21

1:05 pm-11:15 pm

2 stops9h 10m

$325

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 17 results
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Best time to book a flight from Greenville to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to St. Louis

What is the cheapest month to book a flight from Greenville to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Greenville to St. Louis (average of $311). Flying from Greenville to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to STL?

Find hourly flight availability from Greenville to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

When flying from Greenville to St. Louis, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 17% versus a flight in the evening.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 16, 2025.
Read reviews from past customers who have flown Southwest, Delta, and American Airlines from Greenville to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Entertainment

7.5

Crew

8.6

Boarding

8.1

Food

7.0

Comfort

8.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Entertainment

7.5

Crew

8.6

Boarding

8.1

Food

7.0

Comfort

8.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,957 reviews
Southwest
8.0
Very good
4,242 reviews

Entertainment

7.5

Crew

8.6

Boarding

8.1

Food

7.0

Comfort

8.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Entertainment

7.5

Crew

8.6

Boarding

8.1

Food

7.0

Comfort

8.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Greenville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to St. Louis?

    There are many flights that can get you from Greenville to St. Louis in 4h 50m. Fly via American Airlines or Delta to get the fastest option. Airlines will cover a distance of 523 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Greenville to St. Louis round-trip?

    According to our current data, Delta ($238), American Airlines ($286), and Southwest ($286) offers the cheapest pricing from Greenville to St. Louis. Delta is priced at 37% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Greenville to St. Louis that include hotel bookings?

    Yes. In addition to deals on Greenville to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to St. Louis.

  • Can I find deals for business class flights from Greenville to St. Louis?

    Yes. Cheapflights offers flight deals from Greenville to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Greenville to St. Louis (average of $311). Flying from Greenville to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Greenville to St. Louis

Discover the top 3 airlines that operate flights from Greenville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$238Average$371FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$286Average$366FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$286Average$408FlexibilityNo cancel feeOn-time71%

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