$122+ Cheap flights from Greenville to St. Louis (GSP - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/17. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — STL
Sep 8 — Sep 151
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Greenville to St. Louis
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Cheapest flights from Greenville to St. LouisExplore the most affordable flight options available from Greenville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 9, 2026.
Explore the most affordable flight options available from Greenville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 9, 2026.
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:43 pm -
1 stop5h 17m
Wed 8/268:40 am -
1 stop4h 39m
Deal found 8/7![United Airlines logo]()
$254
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:05 pm -
1 stop4h 35m
Sat 8/2910:16 am -
1 stop5h 22m
Deal found 8/7![American Airlines logo]()
$259
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:45 am -
2 stops7h 30m
Sat 8/2911:15 am -
1 stop6h 45m
Deal found 8/7![Southwest logo]()
$264
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:28 pm -
1 stop6h 13m
Sun 9/67:35 am -
1 stop5h 36m
Deal found 8/6![American Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:55 pm -
1 stop4h 15m
Sun 9/66:45 am -
2 stops5h 55m
Deal found 8/6![Southwest logo]()
$284
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:40 pm -
2 stops6h 30m
Tue 9/158:35 am -
2 stops7h 10m
Deal found 8/4![Southwest logo]()
$289
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:46 am -
1 stop3h 22m
Thu 8/2712:52 pm -
1 stop5h 17m
Deal found 8/6![Delta logo]()
$293
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/211:00 am -
2 stops7h 55m
Sat 9/55:45 am -
2 stops8h 10m
Deal found 8/4![Southwest logo]()
$298
This American Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:28 pm -
1 stop7h 14m
Thu 9/105:00 am -
1 stop5h 03m
Deal found 8/4![American Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:08 pm -
2 stops16h 32m
Sun 10/258:34 pm -
1 stop18h 13m
Deal found 8/7![Multiple Airlines logo]()
$300
Best flights from Greenville to St. LouisDiscover carefully curated flight deals from Greenville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 9, 2026.
Discover carefully curated flight deals from Greenville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 9, 2026.
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/211:00 am -
2 stops7h 55m
Sat 9/511:15 am -
1 stop6h 45m
Deal found 8/4![Southwest logo]()
$264
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:46 am -
1 stop3h 22m
Thu 8/2712:52 pm -
1 stop5h 17m
Deal found 8/6![Delta logo]()
$293
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:05 pm -
1 stop4h 35m
Mon 8/248:34 am -
1 stop5h 13m
Deal found 8/5![American Airlines logo]()
$328
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:40 pm -
2 stops6h 30m
Tue 9/154:45 pm -
1 stop3h 15m
Deal found 8/4![Southwest logo]()
$284
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/298:15 am -
1 stop7h 35m
Wed 9/302:45 pm -
1 stop5h 10m
Deal found 8/4![Southwest logo]()
$299
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:55 pm -
1 stop4h 15m
Thu 9/106:05 am -
2 stops5h 25m
Deal found 8/4![Southwest logo]()
$304
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:45 pm -
1 stop4h 10m
Thu 12/35:30 am -
2 stops7h 40m
Deal found 8/5![Southwest logo]()
$304
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:15 am -
2 stops7h 55m
Thu 9/312:15 pm -
2 stops8h 25m
Deal found 8/7![Southwest logo]()
$333
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1911:00 am -
2 stops7h 55m
Mon 8/2412:15 pm -
2 stops8h 20m
Deal found 8/5![Southwest logo]()
$338
This Southwest deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/44:40 pm -
2 stops6h 30m
Sun 9/66:45 am -
2 stops5h 55m
Deal found 8/8![Southwest logo]()
$348
Last-minute flights from Greenville to St. LouisDiscover last-minute flight deals from Greenville to St. Louis. Data last updated August 9, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to St. Louis. Data last updated August 9, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:05 pm -
1 stop4h 35m
Sat 8/2910:16 am -
1 stop5h 22m
Deal found 8/7![American Airlines logo]()
$259
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:45 am -
2 stops7h 30m
Sat 8/2911:15 am -
1 stop6h 45m
Deal found 8/7![Southwest logo]()
$264
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:43 pm -
1 stop5h 17m
Wed 8/268:40 am -
1 stop4h 39m
Deal found 8/7![United Airlines logo]()
$254
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:46 am -
1 stop3h 22m
Thu 8/2712:52 pm -
1 stop5h 17m
Deal found 8/6![Delta logo]()
$293
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/211:00 am -
2 stops7h 55m
Sat 9/55:45 am -
2 stops8h 10m
Deal found 8/4![Southwest logo]()
$298
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:28 pm -
1 stop6h 13m
Sun 9/67:35 am -
1 stop5h 36m
Deal found 8/6![American Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:55 pm -
1 stop4h 15m
Sun 9/66:45 am -
2 stops5h 55m
Deal found 8/6![Southwest logo]()
$284
This American Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:28 pm -
1 stop7h 14m
Thu 9/105:00 am -
1 stop5h 03m
Deal found 8/4![American Airlines logo]()
$299
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:55 pm -
1 stop4h 15m
Thu 9/106:05 am -
2 stops5h 25m
Deal found 8/4![Southwest logo]()
$304
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/34:40 pm -
2 stops6h 30m
Sat 9/511:15 am -
1 stop6h 45m
Deal found 8/4![Southwest logo]()
$309
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:40 pm -
2 stops6h 30m
Tue 9/158:35 am -
2 stops7h 10m
Deal found 8/4![Southwest logo]()
$289
One-way flights from Greenville to St. LouisSearch for one-way flight options from Greenville to St. Louis. Find affordable one-way fares based on user searches. Data last updated August 9, 2026.
Search for one-way flight options from Greenville to St. Louis. Find affordable one-way fares based on user searches. Data last updated August 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1710:07 am -
2 stops28h 03m
Deal found 8/7![Multiple Airlines logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:08 pm -
2 stops16h 32m
Deal found 8/7![Multiple Airlines logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:32 pm -
2 stops41h 38m
Deal found 8/8![Multiple Airlines logo]()
$127
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:43 pm -
1 stop5h 17m
Deal found 8/7![United Airlines logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:37 am -
3 stops33h 45m
Deal found 8/6![Multiple Airlines logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/68:37 am -
2 stops33h 45m
Deal found 8/8![Multiple Airlines logo]()
$133
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:00 am -
2 stops8h 10m
Deal found 8/7![Southwest logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/308:37 am -
2 stops33h 45m
Deal found 8/5![Multiple Airlines logo]()
$137
This United Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/610:00 am -
1 stop6h 38m
Deal found 8/8![United Airlines logo]()
$143
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2410:07 am -
2 stops28h 03m
Deal found 8/8![Multiple Airlines logo]()
$147
Find flight deals from Greenville to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $254 (United Airlines) |
One-way from | $122 (Kiwi.com) |
Popular in | January |
Cheapest in | October |
Average price | $398 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 9, 2026.
Use the filters below to find and compare flights from Greenville to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Wed 9/2
11:00 am-5:55 pm
2 stops7h 55m
Lambert-St Louis
Sat 9/5
11:15 am-7:00 pm
1 stop6h 45m
$264
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Fri 9/11
4:40 pm-10:10 pm
2 stops6h 30m
Lambert-St Louis
Tue 9/15
4:45 pm-9:00 pm
1 stop3h 15m
$284
Quickest round-trip
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Wed 8/26
5:46 am-8:08 am
1 stop3h 22m
Lambert-St Louis
Thu 8/27
12:52 pm-7:09 pm
1 stop5h 17m
$293
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Tue 9/29
8:15 am-2:50 pm
1 stop7h 35m
Lambert-St Louis
Wed 9/30
2:45 pm-8:55 pm
1 stop5h 10m
$299
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Thu 9/3
6:55 pm-10:10 pm
1 stop4h 15m
Lambert-St Louis
Thu 9/10
6:05 am-12:30 pm
2 stops5h 25m
$304
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Tue 12/1
6:45 pm-9:55 pm
1 stop4h 10m
Lambert-St Louis
Thu 12/3
5:30 am-2:10 pm
2 stops7h 40m
$304
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Wed 8/19
7:05 pm-10:40 pm
1 stop4h 35m
Lambert-St Louis
Mon 8/24
8:34 am-2:47 pm
1 stop5h 13m
$328
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Tue 9/1
8:15 am-3:10 pm
2 stops7h 55m
Lambert-St Louis
Thu 9/3
12:15 pm-9:40 pm
2 stops8h 25m
$333
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Wed 8/19
11:00 am-5:55 pm
2 stops7h 55m
Lambert-St Louis
Mon 8/24
12:15 pm-9:35 pm
2 stops8h 20m
$338
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Fri 9/4
4:40 pm-10:10 pm
2 stops6h 30m
Lambert-St Louis
Sun 9/6
6:45 am-1:40 pm
2 stops5h 55m
$348
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Greenville to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to St. Louis in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Greenville-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Greenville-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Greenville to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Greenville with our price prediction graph.
GSP-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Greenville to St. Louis
Prices
More
What is the cheapest month to book a flight from Greenville to St. Louis?
Currently, October is the cheapest month in which you can book a flight from Greenville to St. Louis (average of $300). Flying from Greenville to St. Louis in January is currently the most expensive (average of $841). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Greenville to St. Louis?
Airfare is below average for this route at the moment.
Greenville to St. Louis flights typically cost between $368 and $608 in August.The cheapest round-trip price found within the last 5 days was $254 on United Airlines (Aug 25-Aug 26).
What’s the top layover airport for flights from Greenville to St. Louis?
Share of 1-stop round-trip flights from Greenville to St. Louis chosen by Cheapflights users in the past 12 months, using the same layover each way.
Nashville (BNA) – chosen by Cheapflights users on 80% of 1-stop itineraries from Greenville to St. Louis on Cheapflights.
What’s the cheapest layover airport for flights from Greenville to St. Louis?
Average round-trip fare for 1-stop flights from Greenville to St. Louis, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Nashville (BNA) is the most affordable 1-stop option, with an average round-trip price of $348.
What’s the fastest layover option from Greenville to St. Louis?
Shortest average travel time for 1-stop one-way flights from Greenville to St. Louis, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Nashville (BNA) have the shortest average one-way travel time for 1-stop routes: 4h 10m.
Which airport typically offers the quickest layover for flights from Greenville to St. Louis?
Average layover duration for 1-stop one-way flights from Greenville to St. Louis, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Chicago (ORD) offer the fastest connection on this route, with an average layover time of 0h 50m.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated August 9, 2026.
Read reviews from past customers who have flown Southwest,Delta, andAmerican Airlines from Greenville to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Crew
8.6
Boarding
8.1
Overall
8.0
Comfort
8.0
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Crew
8.6
Boarding
8.1
Overall
8.0
Comfort
8.0
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Crew
8.6
Boarding
8.1
Overall
8.0
Comfort
8.0
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Crew
8.6
Boarding
8.1
Overall
8.0
Comfort
8.0
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Greenville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
Fairview Heights
O'Fallon
Fenton
Swansea
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
Farmington
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Top 3 airlines flying from Greenville to St. Louis
Discover the top 3 airlines that operate flights from Greenville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$208 | Average$410 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$268 | Average$478 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$288 | Average$396 | FlexibilityNo cancel fee | On-time63% |