$125+ Cheap flights from Greenville to St. Louis (GSP - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/10. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — STL
Sep 3 — Sep 101
Round-trip
1 adult, Economy
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Find cheap flights from Greenville to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Greenville to St. Louis
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Cheapest flights from Greenville to St. LouisExplore the most affordable flight options available from Greenville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 4, 2026.
Explore the most affordable flight options available from Greenville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 4, 2026.
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:30 am -
1 stop5h 02m
Sat 11/146:00 am -
1 stop6h 21m
Deal found 7/30![United Airlines logo]()
$259
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:00 am -
1 stop6h 15m
Sat 8/298:34 am -
1 stop5h 13m
Deal found 7/31![American Airlines logo]()
$261
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:05 am -
2 stops7h 45m
Sat 11/147:00 am -
1 stop4h 15m
Deal found 7/30![Southwest logo]()
$264
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2212:55 pm -
1 stop8h 45m
Sat 8/299:00 am -
2 stops7h 30m
Deal found 7/31![Southwest logo]()
$270
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:55 pm -
1 stop4h 15m
Mon 9/213:45 pm -
1 stop4h 55m
Deal found 7/30![Southwest logo]()
$276
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/58:05 am -
1 stop3h 46m
Mon 11/95:37 pm -
1 stop3h 40m
Deal found 7/30![Delta logo]()
$277
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:30 pm -
1 stop5h 40m
Tue 9/87:15 am -
1 stop4h 10m
Deal found 8/2![Southwest logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/173:52 pm -
1 stop25h 42m
Mon 9/212:29 pm -
2 stops25h 45m
Deal found 7/31![Multiple Airlines logo]()
$281
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:46 am -
1 stop3h 22m
Thu 8/2712:52 pm -
1 stop5h 17m
Deal found 7/31![Delta logo]()
$293
Best flights from Greenville to St. LouisDiscover carefully curated flight deals from Greenville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 4, 2026.
Discover carefully curated flight deals from Greenville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 4, 2026.
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:05 am -
2 stops7h 45m
Sat 11/147:00 am -
1 stop4h 15m
Deal found 7/30![Southwest logo]()
$264
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/311:28 pm -
1 stop5h 25m
Thu 9/312:52 pm -
1 stop4h 53m
Deal found 7/30![Delta logo]()
$277
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:30 am -
1 stop5h 02m
Sat 10/316:00 am -
1 stop6h 21m
Deal found 8/3![United Airlines logo]()
$379
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:55 pm -
1 stop4h 15m
Mon 9/213:45 pm -
1 stop4h 55m
Deal found 7/30![Southwest logo]()
$276
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:00 am -
1 stop3h 42m
Sat 11/72:25 pm -
1 stop4h 56m
Deal found 7/30![Delta logo]()
$277
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:30 pm -
1 stop5h 40m
Tue 9/87:15 am -
1 stop4h 10m
Deal found 8/2![Southwest logo]()
$279
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/104:40 pm -
2 stops6h 30m
Mon 9/143:45 pm -
1 stop4h 55m
Deal found 8/3![Southwest logo]()
$304
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:05 am -
1 stop6h 15m
Sat 11/77:00 am -
1 stop4h 39m
Deal found 8/1![Delta logo]()
$342
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:40 am -
1 stop9h 40m
Mon 11/94:30 pm -
1 stop5h 25m
Deal found 8/4![Southwest logo]()
$304
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:40 am -
2 stops5h 45m
Sat 8/299:00 am -
2 stops7h 30m
Deal found 7/31![Southwest logo]()
$314
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:05 am -
2 stops7h 40m
Sun 12/131:25 pm -
2 stops8h 30m
Deal found 8/2![Southwest logo]()
$358
Last-minute flights from Greenville to St. LouisDiscover last-minute flight deals from Greenville to St. Louis. Data last updated August 4, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to St. Louis. Data last updated August 4, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:00 am -
1 stop6h 15m
Sat 8/298:34 am -
1 stop5h 13m
Deal found 7/31![American Airlines logo]()
$261
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2212:55 pm -
1 stop8h 45m
Sat 8/299:00 am -
2 stops7h 30m
Deal found 7/31![Southwest logo]()
$270
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:46 am -
1 stop3h 22m
Thu 8/2712:52 pm -
1 stop5h 17m
Deal found 7/31![Delta logo]()
$293
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/311:28 pm -
1 stop5h 25m
Thu 9/312:52 pm -
1 stop4h 53m
Deal found 7/30![Delta logo]()
$277
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:30 pm -
1 stop5h 40m
Tue 9/87:15 am -
1 stop4h 10m
Deal found 8/2![Southwest logo]()
$279
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/77:17 am -
1 stop5h 29m
Fri 9/117:05 am -
1 stop4h 45m
Deal found 7/31![Delta logo]()
$302
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/104:40 pm -
2 stops6h 30m
Mon 9/143:45 pm -
1 stop4h 55m
Deal found 8/3![Southwest logo]()
$304
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:55 pm -
1 stop4h 15m
Mon 9/213:45 pm -
1 stop4h 55m
Deal found 7/30![Southwest logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/173:52 pm -
1 stop25h 42m
Mon 9/212:29 pm -
2 stops25h 45m
Deal found 7/31![Multiple Airlines logo]()
$281
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:23 pm -
1 stop7h 04m
Sat 9/2611:01 am -
1 stop5h 52m
Deal found 7/31![American Airlines logo]()
$299
One-way flights from Greenville to St. LouisSearch for one-way flight options from Greenville to St. Louis. Find affordable one-way fares based on user searches. Data last updated August 4, 2026.
Search for one-way flight options from Greenville to St. Louis. Find affordable one-way fares based on user searches. Data last updated August 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:07 am -
2 stops28h 03m
Deal found 8/2![Multiple Airlines logo]()
$125
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:15 am -
1 stop7h 35m
Deal found 7/31![Southwest logo]()
$130
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:00 am -
2 stops8h 10m
Deal found 8/4![Southwest logo]()
$135
This American Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/104:49 pm -
1 stop5h 35m
Deal found 8/2![American Airlines logo]()
$150
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/183:01 pm -
2 stops7h 59m
Deal found 7/31![United Airlines logo]()
$177
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:18 pm -
3 stops44h 17m
Deal found 8/2![Multiple Airlines logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:07 am -
3 stops31h 43m
Deal found 8/4![Multiple Airlines logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/183:46 pm -
3 stops50h 36m
Deal found 7/31![Multiple Airlines logo]()
$241
Find flight deals from Greenville to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $259 (United Airlines) |
One-way from | $125 (Kiwi.com) |
Popular in | January |
Cheapest in | October |
Average price | $398 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
Use the filters below to find and compare flights from Greenville to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Wed 11/11
7:05 am-1:50 pm
2 stops7h 45m
Lambert-St Louis
Sat 11/14
7:00 am-12:15 pm
1 stop4h 15m
$264
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Thu 9/17
6:55 pm-10:10 pm
1 stop4h 15m
Lambert-St Louis
Mon 9/21
3:45 pm-9:40 pm
1 stop4h 55m
$276
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Mon 8/31
1:28 pm-5:53 pm
1 stop5h 25m
Lambert-St Louis
Thu 9/3
12:52 pm-6:45 pm
1 stop4h 53m
$277
Quickest round-trip
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Sat 11/7
7:00 am-9:42 am
1 stop3h 42m
Lambert-St Louis
Sat 11/7
2:25 pm-8:21 pm
1 stop4h 56m
$277
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Tue 9/1
5:30 pm-10:10 pm
1 stop5h 40m
Lambert-St Louis
Tue 9/8
7:15 am-12:25 pm
1 stop4h 10m
$279
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Thu 9/10
4:40 pm-10:10 pm
2 stops6h 30m
Lambert-St Louis
Mon 9/14
3:45 pm-9:40 pm
1 stop4h 55m
$304
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Mon 11/9
6:40 am-3:20 pm
1 stop9h 40m
Lambert-St Louis
Mon 11/9
4:30 pm-10:55 pm
1 stop5h 25m
$304
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Sat 8/22
8:40 am-1:25 pm
2 stops5h 45m
Lambert-St Louis
Sat 8/29
9:00 am-5:30 pm
2 stops7h 30m
$314
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Fri 11/6
8:05 am-1:20 pm
1 stop6h 15m
Lambert-St Louis
Sat 11/7
7:00 am-12:39 pm
1 stop4h 39m
$342
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Thu 12/10
7:05 am-1:45 pm
2 stops7h 40m
Lambert-St Louis
Sun 12/13
1:25 pm-10:55 pm
2 stops8h 30m
$358
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Greenville to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to St. Louis in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Greenville-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Greenville-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Greenville to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Greenville with our price prediction graph.
GSP-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Greenville to St. Louis
Prices
More
What is the cheapest month to book a flight from Greenville to St. Louis?
Currently, October is the cheapest month in which you can book a flight from Greenville to St. Louis (average of $286). Flying from Greenville to St. Louis in January is currently the most expensive (average of $841). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Greenville to St. Louis?
Airfare is below average for this route at the moment.
Greenville to St. Louis flights typically cost between $368 and $608 in November.The cheapest round-trip price found within the last 5 days was $259 on United Airlines (Nov 11-Nov 14).
What’s the top layover airport for flights from Greenville to St. Louis?
Share of 1-stop round-trip flights from Greenville to St. Louis chosen by Cheapflights users in the past 12 months, using the same layover each way.
Nashville (BNA) – chosen by Cheapflights users on 80% of 1-stop itineraries from Greenville to St. Louis on Cheapflights.
What’s the cheapest layover airport for flights from Greenville to St. Louis?
Average round-trip fare for 1-stop flights from Greenville to St. Louis, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Nashville (BNA) is the most affordable 1-stop option, with an average round-trip price of $348.
What’s the fastest layover option from Greenville to St. Louis?
Shortest average travel time for 1-stop one-way flights from Greenville to St. Louis, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Nashville (BNA) have the shortest average one-way travel time for 1-stop routes: 4h 10m.
Which airport typically offers the quickest layover for flights from Greenville to St. Louis?
Average layover duration for 1-stop one-way flights from Greenville to St. Louis, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Chicago (ORD) offer the fastest connection on this route, with an average layover time of 0h 50m.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated August 4, 2026.
Read reviews from past customers who have flown Southwest,Delta, andAmerican Airlines from Greenville to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Greenville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
Fairview Heights
O'Fallon
Fenton
Swansea
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
Farmington
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Alternative routes for Greenville to St. Louis
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Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
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Greenville and St. Louis flights
Browse other Greenville and St. Louis flight options. Last updated on August 4, 2026.
Other flights from Greenville
Browse through other flights departing from Greenville. Flights are based on user searches made on Cheapflights and were last updated on August 4, 2026.
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Other flights to St. Louis
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Top 3 airlines flying from Greenville to St. Louis
Discover the top 3 airlines that operate flights from Greenville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$208 | Average$410 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$268 | Average$478 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$288 | Average$396 | FlexibilityNo cancel fee | On-time63% |