How popular is this Fort Myers to St. Louis flight route?

Flights from Fort Myers SW Florida Intl to Lambert-St Louis have been viewed 18 times in the past calendar month.

How long is the flight from Fort Myers to St. Louis?

A quick flight from Fort Myers to St. Louis can take about 5h 26m. American Airlines provides one of the quickest options available for as low as $159. The distance from Fort Myers to St. Louis is about 980 mi. This flight may include one or multiple stops.

What are the cheapest airlines flying from Fort Myers to St. Louis round-trip?

Flying on Southwest is currently your cheapest option to St. Louis, with prices starting at $177. Additional round-trip tickets that might be worth considering are offered by American Airlines and Delta, with the lowest prices starting at $181 and $196, respectively. Users have found that Southwest is 54% cheaper than the other options available to this destination.

What is the cheapest day to fly from Fort Myers to St. Louis?

Travelers seeking maximum savings on their Fort Myers to St. Louis flight should consider departing on Thursday evenings when fares are most often at their lowest. Monday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the cheapest flights from Fort Myers to St. Louis?

While on average a flight from Fort Myers to St. Louis is generally $280, our data shows the cheapest flight currently is $68. When looking at the most popular route, (Fort Myers SW Florida Intl - Lambert-St Louis), you can expect to pay $151 for that flight.

What are the most popular airlines that fly from Fort Myers to St. Louis?

American Airlines, Delta and Southwest are the most popular airlines when flying from Fort Myers to St. Louis.

What is the cheapest day to fly round-trip from Fort Myers to St. Louis?

Travelers have found that booking a Wednesday departure is the best way to save up to 26% on the cost of booking your flights compared to booking on days of the week where this route is of high demand.

How far in advance should I book a flight from Fort Myers to St. Louis?

To save up to 215% on this flight, we recommend booking at least 37 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from Fort Myers to St. Louis from $378 1-2 weeks out and tickets from $618 for flights departing within the next 72 hours.

What is the cheapest month to fly from Fort Myers to St. Louis?

August can be a great time to fly to St. Louis from Fort Myers with a flight ticket averaging about $389. Cheapflights users have found deals in the month of August for as cheap as $147. The most expensive prices can be found in the month of February.

What airports do I use to fly from Fort Myers to St. Louis?

If you wish to fly to St. Louis from Fort Myers, then you need to book flights from Fort Myers SW Florida Intl to Lambert-St Louis. There is 1 flight from SW Florida Intl (RSW) to Lambert-St Louis (STL) per day to choose from. Flights to St. Louis from SW Florida Intl are available from 3 different airlines, which means you should have some options if you want to compare airfare deals. 2h 30m is how long a nonstop flight from Fort Myers to Lambert-St Louis typically takes.

Can I find deals for flights from Fort Myers to St. Louis that include hotel bookings?

Yes. In addition to deals on Fort Myers to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Fort Myers to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to St. Louis.

Can I find deals for business class flights from Fort Myers to St. Louis?

Yes. Cheapflights offers flight deals from Fort Myers to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$64+ Cheap Flights from Fort Myers to St. Louis

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

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Cheapflights Tip: The best prices from Fort Myers SW Florida Intl to Lambert-St Louis are usually found in August or July, booked 82 days in advance, depart on a Thursday or Wednesday and return on a Wednesday

Cheap flight deals from Fort Myers to St. Louis

Round-trip from	$159 (American Airlines)
One-way from	$64 (Southwest)
Popular in	February
Cheapest in	August
Average price	$358

From Fort Myers SW Florida Intl to Lambert-St Louis

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One-way flight from Fort Myers SW Florida Intl to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 14% potential increase in price ($66 potential increase over avg. RT price).

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Cheapest flight prices on average. 4% potential price decrease ($18 potential savings vs. average RT price).

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Average for round-trip flights in September 2025

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Find flight deals from Fort Myers to St. Louis

Cheapest flights from Fort Myers to St. Louis
Explore the most affordable flight options available from Fort Myers to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Thu 11/135:20 pmRSW - STL

1 stop7h 45mAmerican Airlines

Mon 11/172:05 pmSTL - RSW

1 stop4h 47mAmerican Airlines

Deal found 9/14

$159

Tue 10/144:44 pmRSW - STL

2 stops8h 10mAmerican Airlines

Tue 10/218:30 amSTL - RSW

1 stop6h 24mAmerican Airlines

Deal found 9/14

$164

Thu 10/165:55 pmRSW - STL

1 stop5h 30mSouthwest

Sun 10/199:05 amSTL - RSW

1 stop7h 55mSouthwest

Deal found 9/15

$167

Fri 11/219:10 amRSW - STL

1 stop6h 15mUnited Airlines

Sun 11/2311:05 amSTL - RSW

1 stop8h 11mUnited Airlines

Deal found 9/12

$183

Thu 12/185:08 pmRSW - STL

1 stop5h 47mUnited Airlines

Sat 1/37:00 amSTL - RSW

1 stop6h 37mUnited Airlines

Deal found 9/14

$190

Wed 11/128:05 amRSW - STL

1 stop6h 46mDelta

Sun 11/166:40 amSTL - RSW

1 stop5h 14mDelta

Deal found 9/14

$197

Sun 10/57:05 pmRSW - STL

1 stop6h 00mSouthwest

Wed 10/86:55 amSTL - RSW

1 stop5h 05mSouthwest

Deal found 9/12

$199

Fri 10/105:14 pmRSW - STL

1 stop5h 46mUnited Airlines

Mon 10/1312:25 pmSTL - RSW

1 stop7h 43mUnited Airlines

Deal found 9/13

$208

Wed 11/127:50 amRSW - STL

Nonstop2h 40mSouthwest

Sun 11/167:55 amSTL - RSW

Nonstop2h 30mSouthwest

Deal found 9/13

$212

Tue 9/307:00 amRSW - STL

1 stop3h 59mDelta

Sat 10/187:05 amSTL - RSW

1 stop7h 01mDelta

Deal found 9/15

$217

Best flights from Fort Myers to St. Louis
Discover carefully curated flight deals from Fort Myers to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2025.

Tue 10/146:39 pmRSW - STL

1 stop5h 26mAmerican Airlines

Tue 10/218:30 amSTL - RSW

1 stop6h 24mAmerican Airlines

Deal found 9/14

$159

Thu 10/165:55 pmRSW - STL

1 stop5h 30mSouthwest

Sun 10/199:05 amSTL - RSW

1 stop7h 55mSouthwest

Deal found 9/15

$167

Wed 11/128:05 amRSW - STL

1 stop6h 46mDelta

Sun 11/166:40 amSTL - RSW

1 stop5h 14mDelta

Deal found 9/14

$197

Wed 11/125:08 pmRSW - STL

1 stop6h 14mUnited Airlines

Sun 11/166:30 amSTL - RSW

1 stop6h 01mUnited Airlines

Deal found 9/13

$221

Sun 10/57:05 pmRSW - STL

1 stop6h 00mSouthwest

Wed 10/86:55 amSTL - RSW

1 stop5h 05mSouthwest

Deal found 9/12

$199

Tue 9/307:00 amRSW - STL

1 stop3h 59mDelta

Sat 10/187:05 amSTL - RSW

1 stop7h 01mDelta

Deal found 9/15

$217

Thu 11/139:10 amRSW - STL

1 stop7h 36mUnited Airlines

Mon 11/174:35 pmSTL - RSW

1 stop5h 40mUnited Airlines

Deal found 9/13

$221

Wed 11/124:40 pmRSW - STL

2 stops6h 40mSouthwest

Sun 11/167:55 amSTL - RSW

Nonstop2h 30mSouthwest

Deal found 9/13

$227

Last-minute flights from Fort Myers to St. Louis
Discover last-minute flight deals from Fort Myers to St. Louis. Data last updated September 15, 2025 and is based on user searches.

Sun 9/285:35 amRSW - STL

1 stop5h 24mDelta

Thu 10/26:42 pmSTL - RSW

1 stop4h 53mDelta

Deal found 9/13

$237

Tue 9/307:00 amRSW - STL

1 stop3h 59mDelta

Sat 10/187:05 amSTL - RSW

1 stop7h 01mDelta

Deal found 9/15

$217

Sun 10/57:05 pmRSW - STL

1 stop6h 00mSouthwest

Wed 10/86:55 amSTL - RSW

1 stop5h 05mSouthwest

Deal found 9/12

$199

Fri 10/105:14 pmRSW - STL

1 stop5h 46mUnited Airlines

Mon 10/1312:25 pmSTL - RSW

1 stop7h 43mUnited Airlines

Deal found 9/13

$208

Tue 10/146:39 pmRSW - STL

1 stop5h 26mAmerican Airlines

Tue 10/218:30 amSTL - RSW

1 stop6h 24mAmerican Airlines

Deal found 9/14

$159

Tue 10/149:05 amRSW - STL

1 stop6h 05mSouthwest

Tue 10/216:40 pmSTL - RSW

Nonstop2h 20mSouthwest

Deal found 9/14

$232

Thu 10/165:55 pmRSW - STL

1 stop5h 30mSouthwest

Sun 10/199:05 amSTL - RSW

1 stop7h 55mSouthwest

Deal found 9/15

$167

One-way flights from Fort Myers to St. Louis
Search for one-way flight options from Fort Myers to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 15, 2025.

Sun 11/27:30 amRSW - STL

Nonstop2h 40mSouthwest

Deal found 9/14

$64

Tue 10/283:25 pmRSW - STL

1 stop9h 19mUnited Airlines

Deal found 9/14

$76

Tue 10/147:00 pmRSW - STL

1 stop4h 05mSouthwest

Deal found 9/12

$78

Sat 12/136:08 pmRSW - STL

1 stop5h 39mAmerican Airlines

Deal found 9/13

$79

Tue 10/144:44 pmRSW - STL

1 stop7h 21mAmerican Airlines

Deal found 9/13

$80

Sat 11/156:00 amRSW - STL

2 stops9h 25mUnited Airlines

Deal found 9/13

$81

Sun 12/145:55 pmRSW - STL

1 stop4h 35mSouthwest

Deal found 9/14

$84

Tue 10/214:44 pmRSW - STL

2 stops8h 10mAmerican Airlines

Deal found 9/13

$85

Thu 10/305:55 pmRSW - STL

2 stops6h 00mSouthwest

Deal found 9/14

$89

Mon 11/175:08 pmRSW - STL

1 stop6h 14mUnited Airlines

Deal found 9/13

$91

Mon 10/135:14 pmRSW - STL

1 stop5h 46mUnited Airlines

Deal found 9/12

$92

Cheapflights Fare Finder

Use the filters below to find and compare flights from Fort Myers to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Fort MyersSt. Louis

RSW - STL

RSWSTL

Fort Myers SW Florida Intl

Tue 10/14

6:39 pm-11:05 pm

1 stop5h 26m

Lambert-St Louis

Tue 10/21

8:30 am-3:54 pm

1 stop6h 24m

$159

Fort MyersSt. Louis

RSW - STL

RSWSTL

Fort Myers SW Florida Intl

Thu 10/16

5:55 pm-10:25 pm

1 stop5h 30m

Lambert-St Louis

Sun 10/19

9:05 am-6:00 pm

1 stop7h 55m

$167

Fort MyersSt. Louis

RSW - STL

RSWSTL

Fort Myers SW Florida Intl

Wed 11/12

8:05 am-1:51 pm

1 stop6h 46m

Lambert-St Louis

Sun 11/16

6:40 am-12:54 pm

1 stop5h 14m

$197

Fort MyersSt. Louis

RSW - STL

RSWSTL

Fort Myers SW Florida Intl

Sun 10/5

7:05 pm-12:05 am

1 stop6h 00m

Lambert-St Louis

Wed 10/8

6:55 am-1:00 pm

1 stop5h 05m

$199

Fort MyersSt. Louis

RSW - STL

RSWSTL

Fort Myers SW Florida Intl

Tue 9/30

7:00 am-9:59 am

1 stop3h 59m

Lambert-St Louis

Sat 10/18

7:05 am-3:06 pm

1 stop7h 01m

$217

Fort MyersSt. Louis

RSW - STL

RSWSTL

Fort Myers SW Florida Intl

Wed 11/12

5:08 pm-10:22 pm

1 stop6h 14m

Lambert-St Louis

Sun 11/16

6:30 am-1:31 pm

1 stop6h 01m

$221

Fort MyersSt. Louis

RSW - STL

RSWSTL

Fort Myers SW Florida Intl

Thu 11/13

9:10 am-3:46 pm

1 stop7h 36m

Lambert-St Louis

Mon 11/17

4:35 pm-11:15 pm

1 stop5h 40m

$221

Fort MyersSt. Louis

RSW - STL

RSWSTL

Fort Myers SW Florida Intl

Wed 11/12

4:40 pm-10:20 pm

2 stops6h 40m

Lambert-St Louis

Sun 11/16

7:55 am-11:25 am

Nonstop2h 30m

$227

Fort MyersSt. Louis

RSW - STL

RSWSTL

Fort Myers SW Florida Intl

Sat 12/13

5:05 pm-9:58 pm

1 stop5h 53m

$76

Fort MyersSt. Louis

RSW - STL

RSWSTL

Fort Myers SW Florida Intl

Wed 11/5

11:41 am-6:47 pm

1 stop8h 06m

$76

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 20 results

The best insider tips for Fort Myers to St. Louis flights

Cheapflights partnered with top experts to bring you the best recommendations for your Fort Myers to St. Louis trip

Airports

RSW

During peak tourist seasons, plan an extra 20 minutes at RSW for check-in due to smaller airline ticket counters.

STL

Use the MetroLink light rail for a convenient and economical way to reach downtown St. Louis from STL.

Our travel experts

Matt Meltzer

Expert on RSW

Taryn White

Expert on STL

Best time to book a flight from Fort Myers to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Fort Myers with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to St. Louis

How far ahead should I book a flight from Fort Myers to St. Louis?

The best time to book flights from Fort Myers to St. Louis is 81 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Fort Myers to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Fort Myers to St. Louis (average of $311). Flying from Fort Myers to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from RSW to STL?

One of the essential ways to save on airfare from Fort Myers to St. Louis is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 12% on airfare.

Reviews of airlines servicing St. Louis

Peruse reviews from past customers who have flown with Southwest, Delta, and American Airlines from Fort Myers to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,245 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Southwest

8.0

Very good

4,245 reviews

Southwest

8.0

Very good

4,245 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Delta

8.0

Very good

7,956 reviews

Southwest

8.0

Very good

4,245 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,245 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

What airports do I use to fly from Fort Myers to St. Louis?
If you wish to fly to St. Louis from Fort Myers, then you need to book flights from Fort Myers SW Florida Intl to Lambert-St Louis. There is 1 flight from SW Florida Intl (RSW) to Lambert-St Louis (STL) per day to choose from. Flights to St. Louis from SW Florida Intl are available from 3 different airlines, which means you should have some options if you want to compare airfare deals. 2h 30m is how long a nonstop flight from Fort Myers to Lambert-St Louis typically takes.
How popular is this Fort Myers to St. Louis flight route?
Flights from Fort Myers SW Florida Intl to Lambert-St Louis have been viewed 18 times in the past calendar month.
How long is the flight from Fort Myers to St. Louis?
A quick flight from Fort Myers to St. Louis can take about 5h 26m. American Airlines provides one of the quickest options available for as low as $159. The distance from Fort Myers to St. Louis is about 980 mi. This flight may include one or multiple stops.
What are the cheapest airlines flying from Fort Myers to St. Louis round-trip?
Flying on Southwest is currently your cheapest option to St. Louis, with prices starting at $177. Additional round-trip tickets that might be worth considering are offered by American Airlines and Delta, with the lowest prices starting at $181 and $196, respectively. Users have found that Southwest is 54% cheaper than the other options available to this destination.
What are the cheapest flights from Fort Myers to St. Louis?
While on average a flight from Fort Myers to St. Louis is generally $280, our data shows the cheapest flight currently is $68. When looking at the most popular route, (Fort Myers SW Florida Intl - Lambert-St Louis), you can expect to pay $151 for that flight.
Can I find deals for flights from Fort Myers to St. Louis that include hotel bookings?
Yes. In addition to deals on Fort Myers to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Fort Myers to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to St. Louis.
Can I find deals for business class flights from Fort Myers to St. Louis?
Yes. Cheapflights offers flight deals from Fort Myers to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Fort Myers to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Fort Myers to St. Louis (average of $311). Flying from Fort Myers to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Edwardsville

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Maryland Heights

Collinsville

Eureka

Glencoe

St. Peters

Chesterfield

Alton

Farmington

Festus

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Top 3 airlines flying from Fort Myers to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Southwest	Cheapest$177	Average$373	FlexibilityNo cancel fee	On-time63%
American Airlines	Cheapest$181	Average$295	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$196	Average$356	FlexibilityNo cancel fee	On-timeN/A

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$64+ Cheap flights from Fort Myers to St. Louis (RSW - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/2. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Fort Myers to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Fort Myers SW Florida Intl to Lambert-St Louis are usually found in August or July, booked 82 days in advance, depart on a Thursday or Wednesday and return on a Wednesday

Cheap flight deals from Fort Myers to St. Louis

Round-trip from

One-way from

Popular in

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Find flight deals from Fort Myers to St. Louis

Cheapest flights from Fort Myers to St. LouisExplore the most affordable flight options available from Fort Myers to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Explore the most affordable flight options available from Fort Myers to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Fort Myers to St. Louis that are best for you.

The best insider tips for Fort Myers to St. Louis flights

Cheapflights partnered with top experts to bring you the best recommendations for your Fort Myers to St. Louis trip

Airports

RSW

STL

Our travel experts

Best time to book a flight from Fort Myers to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Fort Myers with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Fort Myers to St. Louis

How far ahead should I book a flight from Fort Myers to St. Louis?

What is the cheapest month to book a flight from Fort Myers to St. Louis?

What is the cheapest time of day to fly from RSW to STL?

Reviews of airlines servicing St. Louis

Peruse reviews from past customers who have flown with Southwest, Delta, and American Airlines from Fort Myers to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Fort Myers to St. Louis?

How popular is this Fort Myers to St. Louis flight route?

How long is the flight from Fort Myers to St. Louis?

What are the cheapest airlines flying from Fort Myers to St. Louis round-trip?

What are the cheapest flights from Fort Myers to St. Louis?

Can I find deals for flights from Fort Myers to St. Louis that include hotel bookings?

How can I find direct flights from Fort Myers to St. Louis?

Can I find deals for business class flights from Fort Myers to St. Louis?

What is the cheapest month to book a flight from Fort Myers to St. Louis?

Traveling to a place near St. Louis?

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Alternative routes for Fort Myers to St. Louis

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Top 3 airlines flying from Fort Myers to St. Louis

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Cheapest flights from Fort Myers to St. Louis
Explore the most affordable flight options available from Fort Myers to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.