HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Spain

$326+ Cheap flights from Knoxville (TYS) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MAD
Jan 22 — Jan 291
Thu 1/22
Thu 1/29
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Spain with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Spain

Cheapest flights from Knoxville to Spain
Explore the most affordable flight options available from Knoxville to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

This Ovago deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:25 pmTYS - MAD
1 stop32h 30mMultiple Airlines
Fri 1/210:00 amMAD - TYS
1 stop14h 31mMultiple Airlines
Deal found 12/21$1,494
This Ovago deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:20 pmTYS - MAD
2 stops29h 30mFinnair
Fri 1/210:00 amMAD - TYS
1 stop14h 31mFinnair
Deal found 12/21$1,606
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:08 pmTYS - MAD
2 stops33h 47mAmerican Airlines
Fri 1/210:00 amMAD - TYS
2 stops19h 47mAmerican Airlines
Deal found 12/22$1,687
This United Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:23 pmTYS - MAD
2 stops34h 22mUnited Airlines
Fri 1/26:25 amMAD - TYS
2 stops22h 14mUnited Airlines
Deal found 12/21$1,754
This oojo deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/283:01 pmTYS - MAD
2 stops21h 24mIberia
Sun 1/48:35 pmMAD - TYS
2 stops30h 46mIberia
Deal found 12/21$1,949
This Kiwi.com deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/286:00 amTYS - BCN
1 stop23h 55mMultiple Airlines
Sun 1/49:15 pmBCN - TYS
2 stops49h 32mMultiple Airlines
Deal found 12/21$2,023
This Kiwi.com deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2810:04 pmTYS - MAD
1 stop27h 51mMultiple Airlines
Sun 1/49:35 pmMAD - TYS
2 stops49h 12mMultiple Airlines
Deal found 12/21$2,048
This Ovago deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/282:00 pmTYS - BCN
1 stop12h 20mLufthansa
Sun 1/410:30 amBCN - TYS
1 stop15h 21mLufthansa
Deal found 12/21$2,351
This KLM deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/286:59 pmTYS - BCN
2 stops15h 31mKLM
Sun 1/41:00 pmBCN - TYS
2 stops16h 26mKLM
Deal found 12/21$2,405
This Air Canada deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/239:50 amTYS - MAD
3 stops16h 10mAir Canada
Fri 1/27:40 amMAD - TYS
3 stops22h 19mAir Canada
Deal found 12/21$5,621
This Cheapflightsfares deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2311:00 amTYS - BCN
2 stops18h 55mLufthansa
Mon 12/296:30 pmBCN - TYS
2 stops34h 09mLufthansa
Deal found 12/22$7,662
This AranGrant deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure AranGrant is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:01 pmTYS - BCN
1 stop30h 04mFinnair
Mon 12/2912:30 pmBCN - TYS
1 stop14h 13mFinnair
Deal found 12/22$8,844

Find flight deals from Knoxville to Spain

Keep the following information in mind while searching for Knoxville to Spain flight deals. Data was last updated December 23, 2025.

Round-trip from

$462
(Flysmarter)

One-way from

$326
(American Airlines)

Popular in

June

Cheapest in

January

Average price

$894
From Knoxville McGhee Tyson to Spain
Search Deals
One-way flight from Knoxville McGhee Tyson to Spain
Search Deals
Highest demand for flights based on searches. 28% potential increase in price ($374 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($59 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Knoxville to Spain that are best for you.

Fly from

Knoxville

Fly to

Spain

Route

Depart

Return

Price

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Mon 2/23

4:03 pm-8:40 am

1 stop10h 37m

Barcelona-El Prat

Tue 3/3

10:15 am-8:00 pm

2 stops15h 45m

$462

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Mon 2/23

6:45 am-9:35 am

2 stops20h 50m

Barcelona-El Prat

Tue 3/3

1:35 pm-8:37 pm

2 stops37h 02m

$468

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Mon 1/19

6:45 am-9:35 am

2 stops20h 50m

Barcelona-El Prat

Mon 1/26

1:35 pm-7:27 pm

2 stops35h 52m

$468

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Fri 1/23

6:59 am-9:15 am

2 stops20h 16m

Madrid Barajas

Mon 1/26

1:35 pm-7:27 pm

2 stops35h 52m

$473

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Mon 2/23

6:40 am-9:00 am

1 stop20h 20m

Barcelona-El Prat

Tue 3/3

10:40 am-9:39 pm

1 stop16h 59m

$475

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Sun 2/15

5:27 pm-11:35 pm

2 stops24h 08m

Madrid Barajas

Sun 2/22

5:55 am-8:37 pm

2 stops20h 42m

$477

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Fri 1/23

7:44 am-9:00 am

1 stop19h 16m

Barcelona-El Prat

Sun 1/25

12:30 pm-8:56 pm

1 stop14h 26m

$482

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Sat 1/31

2:19 pm-9:00 am

1 stop12h 41m

Barcelona-El Prat

Wed 2/11

12:30 pm-8:56 pm

1 stop14h 26m

$484

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Mon 1/19

12:19 pm-8:50 am

1 stop14h 31m

Barcelona-El Prat

Mon 1/26

10:40 am-10:47 pm

1 stop18h 07m

$484

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Sat 2/14

5:42 am-7:05 am

1 stop19h 23m

Barcelona-El Prat

Sat 2/21

12:30 pm-9:48 pm

1 stop15h 18m

$484

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/20

Showing 1-10 of 38 results
1
2
3
4

Best time to book a flight from Knoxville to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Spain

What is the cheapest month to book a flight from Knoxville to Spain?

Currently, October is the cheapest month in which you can book a flight from Knoxville to Spain (average of $181). Flying from Knoxville to Spain in June is currently the most expensive (average of $919). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to ES?

Find hourly flight availability from Knoxville to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 23, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Spain in the evening. If you’re flexible enough to do this you can expect to save up to 21% on your trip compared to booking a flight in the afternoon.

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated December 23, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Spain have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,013 reviews

Entertainment

7.9

Boarding

8.1

Food

7.3

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,013 reviews
Delta
7.9
Good
8,013 reviews

Entertainment

7.9

Boarding

8.1

Food

7.3

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,102 reviews
Delta
7.9
Good
8,013 reviews

Entertainment

7.9

Boarding

8.1

Food

7.3

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,052 reviews
Delta
7.9
Good
8,013 reviews

Entertainment

7.9

Boarding

8.1

Food

7.3

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
British Airways
6.7
Okay
7,605 reviews
Delta
7.9
Good
8,013 reviews

Entertainment

7.9

Boarding

8.1

Food

7.3

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Spain?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Spain. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Spain?

    Airlines like KLM, United Airlines, and Lufthansa fly from Knoxville to Spain in about 10h 37m. The time it takes to get you to your destination can typically vary by up to 13h 31m. The distance between Knoxville and Spain is about 4465 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Spain?

    The most popular route from Knoxville to Spain is Knoxville McGhee Tyson - Barcelona-El Prat. You may also consider Knoxville McGhee Tyson - Malaga or Knoxville McGhee Tyson - Madrid Barajas.

  • Can I find deals for flights from Knoxville to Spain that include hotel bookings?

    Yes. In addition to deals on Knoxville to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Spain.

  • Can I find deals for business class flights from Knoxville to Spain?

    Yes. Cheapflights offers flight deals from Knoxville to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Spain?

    Currently, October is the cheapest month in which you can book a flight from Knoxville to Spain (average of $181). Flying from Knoxville to Spain in June is currently the most expensive (average of $919). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Spain

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Heathrow flights
Nashville to Dublin flights
Nashville to Gatwick flights
Nashville to Leonardo da Vinci/Fiumicino flights
Nashville to Orly flights
Nashville to Charles de Gaulle flights
Nashville to London City flights
Nashville to Stansted flights
Nashville to Keflavik Intl flights
Nashville to Athens flights
Nashville to Frankfurt flights
Nashville to Barcelona-El Prat flights
Nashville to Zurich flights
Nashville to Madrid flights
Memphis to Heathrow flights
Nashville to Edinburgh flights
Knoxville to Frankfurt flights
Nashville to Malpensa flights
Memphis to Leonardo da Vinci/Fiumicino flights
Nashville to Lisbon flights
Nashville to Amsterdam flights
Memphis to Charles de Gaulle flights
Memphis to Orly flights
Nashville to Istanbul flights
Nashville to Vicenza flights
Knoxville to Heathrow flights
Nashville to Linate flights
Nashville to Copenhagen flights
Nashville to Bruxelles-National flights
Memphis to Gatwick flights
Memphis to Barcelona-El Prat flights
Knoxville to Charles de Gaulle flights
Nashville to Prague flights
Knoxville to Barcelona-El Prat flights
Nashville to Arlanda flights
Nashville to Glasgow Intl flights
Knoxville to Dublin flights
Memphis to Athens flights
Knoxville to Leonardo da Vinci/Fiumicino flights
Nashville to Frederic Chopin flights
Nashville to Sabiha Gokcen flights
Chattanooga to Dublin flights
Memphis to Dublin flights
Nashville to Oslo Gardermoen flights
Memphis to Amsterdam flights
Nashville to Florence flights
Nashville to Budapest flights
Chattanooga to Heathrow flights
Nashville to Munich flights
Memphis to Munich flights

Top 4 airlines flying from Knoxville to Spain

Discover the top 4 airlines that operate flights from Knoxville to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$433Average$1,276FlexibilityNo cancel feeOn-timeN/A
British AirwaysCheapest$483Average$831FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$605Average$1,186FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$732Average$1,150FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.