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$234+ Cheap flights from Knoxville (TYS) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/2. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MAD
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Knoxville to Spain

Keep the following information in mind while searching for Knoxville to Spain flight deals. Data was last updated September 17, 2025.

Round-trip from

$530
(American Airlines)

One-way from

$234
(Kiwi.com)

Popular in

June

Cheapest in

November

Average price

$850
From Knoxville McGhee Tyson to Spain
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One-way flight from Knoxville McGhee Tyson to Spain
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Highest demand for flights based on searches. 23% potential increase in price ($315 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($55 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Spain

Cheapest flights from Knoxville to Spain
Explore the most affordable flight options available from Knoxville to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/61:01 pmTYS - MAD
1 stop12h 54mAmerican Airlines
Wed 10/2211:50 amMAD - TYS
1 stop16h 19mAmerican Airlines
Deal found 9/13$530
This Finnair deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/251:25 pmTYS - MAD
1 stop10h 20mMultiple Airlines
Fri 12/511:35 amMAD - TYS
1 stop16h 03mMultiple Airlines
Deal found 9/16$537
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/258:59 amTYS - MAD
1 stop14h 46mAmerican Airlines
Fri 12/512:30 pmMAD - TYS
2 stops15h 06mAmerican Airlines
Deal found 9/16$542
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/115:45 amTYS - MAD
2 stops20h 15mUnited Airlines
Wed 11/195:55 amMAD - TYS
2 stops24h 04mUnited Airlines
Deal found 9/13$543
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/255:45 amTYS - MAD
2 stops28h 25mUnited Airlines
Fri 12/51:35 pmMAD - TYS
2 stops31h 08mUnited Airlines
Deal found 9/16$546
This lol.travel deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lol.travel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/299:10 amTYS - BCN
2 stops18h 50mUnited Airlines
Mon 11/1011:00 amBCN - TYS
2 stops29h 48mUnited Airlines
Deal found 9/15$550
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/53:59 pmTYS - MAD
2 stops17h 21mDelta
Thu 11/1311:15 amMAD - TYS
1 stop14h 51mDelta
Deal found 9/13$556
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/45:45 amTYS - BCN
2 stops21h 50mUnited Airlines
Thu 11/133:05 pmBCN - TYS
1 stop35h 28mUnited Airlines
Deal found 9/15$558
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/65:45 amTYS - MAD
2 stops20h 15mUnited Airlines
Fri 11/141:35 pmMAD - TYS
2 stops39h 20mUnited Airlines
Deal found 9/15$564
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/51:52 pmTYS - MAD
2 stops20h 48mUnited Airlines
Fri 11/141:35 pmMAD - TYS
2 stops26h 30mUnited Airlines
Deal found 9/15$565
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/51:52 pmTYS - MAD
2 stops20h 48mUnited Airlines
Wed 11/195:55 amMAD - TYS
2 stops23h 00mUnited Airlines
Deal found 9/15$571
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/93:51 pmTYS - MAD
1 stop11h 24mDelta
Wed 11/196:00 amMAD - TYS
2 stops19h 00mDelta
Deal found 9/15$576

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Knoxville to Spain that are best for you.

Fly from

Knoxville

Fly to

Spain

Route

Depart

Return

Price

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Tue 11/25

1:25 pm-5:45 am

1 stop10h 20m

Madrid Barajas

Fri 12/5

11:35 am-9:38 pm

1 stop16h 03m

$537

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Wed 10/29

9:10 am-9:00 am

2 stops18h 50m

Barcelona-El Prat

Mon 11/10

11:00 am-10:48 am

2 stops29h 48m

$550

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Sun 3/8

5:50 am-8:20 am

1 stop21h 30m

Barcelona-El Prat

Tue 3/17

10:30 am-6:42 pm

1 stop13h 12m

$553

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Tue 11/4

5:45 am-9:35 am

2 stops21h 50m

Barcelona-El Prat

Thu 11/13

3:05 pm-8:33 pm

1 stop35h 28m

$558

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Wed 11/5

3:59 pm-3:20 pm

2 stops17h 21m

Madrid Barajas

Thu 11/13

10:00 am-8:06 pm

2 stops16h 06m

$561

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Thu 11/6

5:45 am-8:00 am

2 stops20h 15m

Madrid Barajas

Fri 11/14

1:35 pm-2:43 pm

2 stops31h 08m

$564

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Thu 11/6

5:45 am-8:00 am

2 stops20h 15m

Madrid Barajas

Fri 11/14

1:35 pm-10:55 pm

2 stops39h 20m

$564

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Mon 2/16

2:45 pm-9:15 am

2 stops12h 30m

Madrid Barajas

Mon 2/23

1:35 pm-9:07 pm

2 stops37h 32m

$569

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Sat 1/31

1:59 pm-9:35 am

2 stops37h 36m

Barcelona-El Prat

Wed 2/11

6:45 am-7:27 pm

2 stops18h 42m

$570

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Mon 11/10

1:52 pm-3:50 pm

2 stops19h 58m

Madrid Barajas

Wed 11/19

5:55 am-11:59 pm

2 stops24h 04m

$570

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 45 results
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Best time to book a flight from Knoxville to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Spain

What is the cheapest month to book a flight from Knoxville to Spain?

Currently, November is the cheapest month in which you can book a flight from Knoxville to Spain (average of $543). Flying from Knoxville to Spain in June is currently the most expensive (average of $1,054). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to ES?

Find hourly flight availability from Knoxville to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

When flying from Knoxville to Spain, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated September 17, 2025.
See what other customers who have flown with Delta, KLM, and United Airlines from Knoxville to Spain have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,957 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,957 reviews
Delta
8.0
Very good
7,957 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
KLM
7.8
Good
1,386 reviews
Delta
8.0
Very good
7,957 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,924 reviews
Delta
8.0
Very good
7,957 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,957 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
British Airways
6.7
Okay
7,363 reviews
Delta
8.0
Very good
7,957 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Spain?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Spain. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Spain?

    Airlines like United Airlines, Delta, and Air Canada fly from Knoxville to Spain in about 17h 21m. The time it takes to get you to your destination can typically vary by up to 2h 54m. The distance between Knoxville and Spain is about 4222 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Spain?

    The most popular route from Knoxville to Spain is Knoxville McGhee Tyson - Madrid Barajas. You may also consider Knoxville McGhee Tyson - Barcelona-El Prat or Knoxville McGhee Tyson - Malaga.

  • Can I find deals for flights from Knoxville to Spain that include hotel bookings?

    Yes. In addition to deals on Knoxville to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Spain.

  • Can I find deals for business class flights from Knoxville to Spain?

    Yes. Cheapflights offers flight deals from Knoxville to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Spain?

    Currently, November is the cheapest month in which you can book a flight from Knoxville to Spain (average of $543). Flying from Knoxville to Spain in June is currently the most expensive (average of $1,054). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 5 airlines flying from Knoxville to Spain

Discover the top 5 airlines that operate flights from Knoxville to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
KLMCheapest$530Average$771FlexibilityNo cancel feeOn-time75%
United AirlinesCheapest$562Average$959FlexibilityNo cancel feeOn-time69%
British AirwaysCheapest$594Average$781FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$594Average$1,180FlexibilityNo cancel feeOn-time71%
DeltaCheapest$721Average$1,237FlexibilityNo cancel feeOn-timeN/A

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