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$352+ Cheap flights from Knoxville (TYS) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/4. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MAD
Aug 24 — Aug 311
Mon 8/24
Mon 8/31
1 adult, Economy
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Cheap flight deals from Knoxville to Spain

Cheapest flights from Knoxville to Spain
Explore the most affordable flight options available from Knoxville to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 25, 2026.

This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:45 am
TYS
-
MAD
1 stop20h 00m
United Airlines
Thu 11/261:25 pm
MAD
-
TYS
2 stops29h 55m
United Airlines
Deal found 7/20$710
This United deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/178:30 am
TYS
-
MAD
3 stops17h 30m
Multiple Airlines
Thu 11/261:25 pm
MAD
-
TYS
2 stops29h 55m
Multiple Airlines
Deal found 7/20$714
This Air Canada deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:20 pm
TYS
-
MAD
2 stops54h 40m
Air Canada
Wed 11/251:25 pm
MAD
-
TYS
2 stops29h 55m
Air Canada
Deal found 7/20$719
This Virgin Atlantic deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Virgin Atlantic is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/173:55 pm
TYS
-
MAD
1 stop12h 00m
Virgin Atlantic
Thu 11/2611:55 am
MAD
-
TYS
1 stop17h 51m
Virgin Atlantic
Deal found 7/20$728
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/155:45 am
TYS
-
MAD
1 stop20h 00m
United Airlines
Thu 11/266:00 am
MAD
-
TYS
2 stops20h 44m
United Airlines
Deal found 7/20$730
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:57 pm
TYS
-
MAD
1 stop9h 58m
Delta
Tue 11/246:05 am
MAD
-
TYS
2 stops17h 13m
Delta
Deal found 7/20$732
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/178:30 am
TYS
-
MAD
3 stops17h 30m
United Airlines
Tue 11/246:00 am
MAD
-
TYS
2 stops23h 56m
United Airlines
Deal found 7/20$733
This oojo deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:13 pm
TYS
-
MAD
1 stop12h 17m
British Airways
Wed 10/281:00 pm
MAD
-
TYS
1 stop15h 55m
British Airways
Deal found 7/24$734
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:20 pm
TYS
-
MAD
1 stop30h 25m
United Airlines
Thu 11/266:00 am
MAD
-
TYS
2 stops20h 44m
United Airlines
Deal found 7/20$736
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am
TYS
-
MAD
2 stops21h 00m
United Airlines
Wed 10/2811:00 am
MAD
-
TYS
2 stops27h 53m
United Airlines
Deal found 7/24$740
This Air Canada deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/155:45 am
TYS
-
MAD
2 stops44h 15m
Air Canada
Tue 11/241:25 pm
MAD
-
TYS
2 stops51h 24m
Air Canada
Deal found 7/20$742
This Air Canada deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:20 pm
TYS
-
MAD
2 stops54h 40m
Air Canada
Tue 11/241:25 pm
MAD
-
TYS
2 stops51h 24m
Air Canada
Deal found 7/20$748

Find flight deals from Knoxville to Spain

Keep the following information in mind while searching for Knoxville to Spain flight deals. Data was last updated July 25, 2026.

Round-trip from

$710
(United Airlines)

One-way from

$352
(American Airlines)

Popular in

July

Cheapest in

January

Average price

$1,244
From Knoxville McGhee Tyson to Spain
Search Deals
One-way flight from Knoxville McGhee Tyson to Spain
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($176 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($40 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 25, 2026.
Use the filters below to find and compare flights from Knoxville to Spain that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Mon 11/16

5:45 am-7:45 am

1 stop20h 00m

Madrid Barajas

Tue 11/24

6:00 am-11:56 pm

2 stops23h 56m

$730

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Tue 11/17

2:00 pm-7:45 am

1 stop11h 45m

Madrid Barajas

Tue 11/24

6:00 am-11:56 pm

2 stops23h 56m

$730

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Wed 11/18

8:30 am-8:00 am

3 stops17h 30m

Madrid Barajas

Thu 11/26

6:00 am-8:44 pm

2 stops20h 44m

$733

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Mon 11/9

5:45 am-9:00 am

1 stop21h 15m

Barcelona-El Prat

Fri 11/13

1:35 pm-8:44 pm

2 stops37h 09m

$749

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Wed 11/11

9:45 am-9:35 am

2 stops17h 50m

Barcelona-El Prat

Wed 11/18

1:35 pm-11:56 pm

2 stops40h 21m

$752

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Sun 1/3

5:45 am-7:45 am

1 stop20h 00m

Madrid Barajas

Tue 1/12

11:15 am-8:54 pm

1 stop15h 39m

$753

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Wed 1/6

5:14 pm-2:50 pm

2 stops15h 36m

Madrid Barajas

Wed 1/13

12:40 pm-10:54 pm

1 stop16h 14m

$755

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Tue 10/20

5:45 am-9:55 am

2 stops22h 10m

Madrid Barajas

Tue 11/3

10:00 am-10:27 pm

2 stops18h 27m

$770

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Wed 10/28

7:35 pm-5:40 pm

2 stops17h 05m

Barcelona-El Prat

Fri 11/6

1:35 pm-3:07 pm

2 stops31h 32m

$772

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Wed 10/28

4:57 pm-9:35 am

1 stop11h 38m

Barcelona-El Prat

Fri 11/6

11:00 am-8:17 pm

1 stop15h 17m

$774

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/21

Showing 1-10 of 35 resultsSorted by cheapest first
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Best time to book a flight from Knoxville to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Spain

What is the cheapest month to book a flight from Knoxville to Spain?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Spain (average of $483). Flying from Knoxville to Spain in June is currently the most expensive (average of $1,477). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated July 25, 2026.
See what other customers who have flown with United Airlines,American Airlines, andBritish Airways from Knoxville to Spain have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
10,034 reviews

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Crew

8.1

Entertainment

7.1

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this
United Airlines
7.4
Good
10,034 reviews
United Airlines
7.4
Good
10,034 reviews

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Crew

8.1

Entertainment

7.1

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this
American Airlines
7.1
Good
11,851 reviews
United Airlines
7.4
Good
10,034 reviews

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Crew

8.1

Entertainment

7.1

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this
British Airways
6.7
Okay
8,132 reviews
United Airlines
7.4
Good
10,034 reviews

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Crew

8.1

Entertainment

7.1

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Spain?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Spain. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Spain?

    Airlines like United Airlines, KLM, and British Airways fly from Knoxville to Spain in about 17h 44m. The time it takes to get you to your destination can typically vary by up to 22h 06m. The distance between Knoxville and Spain is about 4288 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Spain?

    The most popular route from Knoxville to Spain is Knoxville McGhee Tyson - Madrid Barajas. You may also consider Knoxville McGhee Tyson - Barcelona-El Prat or Knoxville McGhee Tyson - Malaga.

  • Can I find deals for flights from Knoxville to Spain that include hotel bookings?

    Yes. In addition to deals on Knoxville to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Spain.

  • Can I find deals for business class flights from Knoxville to Spain?

    Yes. Cheapflights offers flight deals from Knoxville to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Spain?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Spain (average of $483). Flying from Knoxville to Spain in June is currently the most expensive (average of $1,477). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Knoxville to Spain

Discover the top 3 airlines that operate flights from Knoxville to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 25, 2026.
AirlineCheapestAverageFlexibilityOn-time
British AirwaysCheapest$432Average$823FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$605Average$873FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$664Average$864FlexibilityNo cancel feeOn-time69%

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