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$288+ Cheap flights from Knoxville (TYS) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/20. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MAD
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheap flight deals from Knoxville to Spain

Keep the following information in mind while searching for Knoxville to Spain flight deals. Data was last updated August 14, 2025.

Round-trip from

$438
(Delta)

One-way from

$288
(Kiwi.com)

Popular in

June

Cheapest in

October

Average price

$1,043
From Knoxville McGhee Tyson to Spain
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One-way flight from Knoxville McGhee Tyson to Spain
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Highest demand for flights based on searches. 23% potential increase in price ($315 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($55 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Knoxville to Spain

Cheapest flights from Knoxville to Spain
Explore the most affordable flight options available from Knoxville to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/55:44 amTYS - MAD
1 stop21h 46mDelta
Thu 11/1311:00 amMAD - TYS
1 stop13h 13mDelta
Deal found 8/13$438
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/55:44 amTYS - MAD
1 stop21h 46mDelta
Wed 11/196:00 amMAD - TYS
2 stops23h 27mDelta
Deal found 8/13$462
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/55:44 amTYS - MAD
1 stop21h 46mDelta
Tue 11/1811:00 amMAD - TYS
2 stops16h 32mDelta
Deal found 8/13$463
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/107:30 amTYS - MAD
2 stops18h 30mDelta
Wed 11/196:00 amMAD - TYS
2 stops22h 59mDelta
Deal found 8/13$466
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/107:30 amTYS - MAD
2 stops18h 30mDelta
Tue 11/1811:00 amMAD - TYS
2 stops16h 32mDelta
Deal found 8/13$468
This Finnair deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/46:00 amTYS - BCN
1 stop19h 05mMultiple Airlines
Thu 11/1311:00 amBCN - TYS
1 stop18h 45mMultiple Airlines
Deal found 8/14$484
This Finnair deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/512:01 pmTYS - MAD
1 stop11h 44mMultiple Airlines
Thu 11/131:00 pmMAD - TYS
1 stop12h 33mMultiple Airlines
Deal found 8/13$488
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/87:20 pmTYS - MAD
1 stop30h 45mUnited Airlines
Sun 11/161:35 pmMAD - TYS
2 stops36h 58mUnited Airlines
Deal found 8/13$490
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/63:59 pmTYS - MAD
1 stop11h 31mDelta
Fri 11/1410:00 amMAD - TYS
2 stops17h 32mDelta
Deal found 8/13$492
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/912:00 pmTYS - MAD
2 stops16h 15mDelta
Wed 11/196:00 amMAD - TYS
2 stops22h 59mDelta
Deal found 8/13$493
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/87:20 pmTYS - MAD
1 stop30h 45mUnited Airlines
Thu 11/136:00 amMAD - TYS
2 stops23h 59mUnited Airlines
Deal found 8/13$494
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/222:16 pmTYS - BCN
1 stop12h 04mUnited Airlines
Wed 10/296:45 amBCN - TYS
2 stops18h 48mUnited Airlines
Deal found 8/12$599

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Knoxville to Spain that are best for you.

Fly from

Knoxville

Fly to

Spain

Route

Depart

Return

Price

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Wed 11/5

5:44 am-9:30 am

1 stop21h 46m

Madrid Barajas

Thu 11/13

11:00 am-6:13 pm

1 stop13h 13m

$438

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Wed 11/5

5:44 am-9:30 am

1 stop21h 46m

Madrid Barajas

Fri 11/14

10:00 am-9:32 pm

2 stops17h 32m

$442

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Wed 11/5

5:44 am-9:30 am

1 stop21h 46m

Madrid Barajas

Wed 11/19

6:00 am-11:27 pm

2 stops23h 27m

$462

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Wed 11/5

5:44 am-9:30 am

1 stop21h 46m

Madrid Barajas

Tue 11/18

11:00 am-9:32 pm

2 stops16h 32m

$463

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Mon 11/10

7:30 am-8:00 am

2 stops18h 30m

Madrid Barajas

Wed 11/19

6:00 am-10:59 pm

2 stops22h 59m

$466

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Tue 11/11

12:00 pm-8:00 am

2 stops14h 00m

Madrid Barajas

Wed 11/19

6:00 am-5:17 pm

2 stops17h 17m

$466

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Mon 11/10

7:30 am-8:00 am

2 stops18h 30m

Madrid Barajas

Tue 11/18

11:00 am-9:32 pm

2 stops16h 32m

$468

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Tue 11/11

10:05 am-8:00 am

2 stops15h 55m

Madrid Barajas

Tue 11/18

11:00 am-9:32 pm

2 stops16h 32m

$468

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Tue 11/4

6:00 am-7:05 am

1 stop19h 05m

Barcelona-El Prat

Thu 11/13

11:00 am-11:45 pm

1 stop18h 45m

$484

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Tue 11/11

6:05 am-5:45 am

1 stop17h 40m

Madrid Barajas

Wed 11/19

1:15 pm-9:04 pm

1 stop13h 49m

$488

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/12

Showing 1-10 of 21 results
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Best time to book a flight from Knoxville to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Spain

What is the cheapest month to book a flight from Knoxville to Spain?

Currently, November is the cheapest month in which you can book a flight from Knoxville to Spain (average of $543). Flying from Knoxville to Spain in June is currently the most expensive (average of $1,053). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to ES?

Find hourly flight availability from Knoxville to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

When flying from Knoxville to Spain, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated August 14, 2025.
See what other customers who have flown with Delta, KLM, and United Airlines from Knoxville to Spain have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
KLM
7.8
Good
1,381 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,916 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
British Airways
6.7
Okay
7,266 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Spain?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Spain. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • What are the most popular routes from Knoxville to Spain?

    The most popular route from Knoxville to Spain is Knoxville McGhee Tyson - Madrid Barajas. You may also consider Knoxville McGhee Tyson - Barcelona-El Prat or Knoxville McGhee Tyson - Malaga.

  • Can I find deals for flights from Knoxville to Spain that include hotel bookings?

    Yes. In addition to deals on Knoxville to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Spain.

  • Can I find deals for business class flights from Knoxville to Spain?

    Yes. Cheapflights offers flight deals from Knoxville to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Spain?

    Currently, November is the cheapest month in which you can book a flight from Knoxville to Spain (average of $543). Flying from Knoxville to Spain in June is currently the most expensive (average of $1,053). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 5 airlines flying from Knoxville to Spain

Discover the top 5 airlines that operate flights from Knoxville to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
KLMCheapest$530Average$828FlexibilityNo cancel feeOn-time75%
United AirlinesCheapest$562Average$958FlexibilityNo cancel feeOn-time69%
British AirwaysCheapest$594Average$781FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$594Average$1,073FlexibilityNo cancel feeOn-time71%
DeltaCheapest$664Average$1,067FlexibilityNo cancel feeOn-timeN/A

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