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$292+ Cheap flights from Knoxville (TYS) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MAD
Apr 6 — Apr 131
Mon 4/6
Mon 4/13
1 adult, Economy
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Cheap flight deals from Knoxville to Spain

Cheapest flights from Knoxville to Spain
Explore the most affordable flight options available from Knoxville to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 7, 2026.

This oojo deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:52 pm
TYS
-
MAD
1 stop13h 33m
British Airways
Wed 1/131:15 pm
MAD
-
TYS
1 stop13h 41m
British Airways
Deal found 3/3$549
This Finnair deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:06 am
TYS
-
MAD
1 stop18h 14m
Multiple Airlines
Tue 10/611:45 am
MAD
-
TYS
1 stop15h 19m
Multiple Airlines
Deal found 3/4$554
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:15 pm
TYS
-
MAD
2 stops16h 50m
Delta
Wed 1/1311:10 am
MAD
-
TYS
2 stops16h 24m
Delta
Deal found 3/3$562
This United Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3010:16 am
TYS
-
MAD
2 stops24h 29m
United Airlines
Tue 10/66:20 am
MAD
-
TYS
2 stops38h 22m
United Airlines
Deal found 3/4$569
This oojo deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/142:49 pm
TYS
-
MAD
1 stop12h 46m
British Airways
Tue 4/213:25 pm
MAD
-
TYS
1 stop12h 32m
British Airways
Deal found 3/2$605
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1410:49 am
TYS
-
MAD
2 stops15h 16m
United Airlines
Tue 4/2111:15 am
MAD
-
TYS
2 stops17h 19m
United Airlines
Deal found 3/2$615
This Scandinavian Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Scandinavian Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:57 pm
TYS
-
AGP
2 stops19h 23m
Scandinavian Airlines
Tue 11/176:30 pm
AGP
-
TYS
2 stops33h 15m
Scandinavian Airlines
Deal found 3/5$634
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:45 am
TYS
-
MAD
1 stop20h 20m
United Airlines
Mon 10/51:30 pm
MAD
-
TYS
2 stops29h 48m
United Airlines
Deal found 3/5$639
This Expedia deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:10 pm
TYS
-
MAD
1 stop33h 10m
Iberia
Sat 4/2511:45 am
MAD
-
TYS
1 stop14h 33m
Iberia
Deal found 3/3$647
This oojo deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:31 am
TYS
-
AGP
2 stops25h 39m
British Airways
Thu 4/234:55 pm
AGP
-
TYS
2 stops34h 26m
British Airways
Deal found 3/2$688
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:00 am
TYS
-
BCN
1 stop17h 45m
American Airlines
Fri 4/243:30 pm
BCN
-
TYS
1 stop14h 29m
American Airlines
Deal found 3/3$706
This United Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:26 am
TYS
-
BCN
2 stops19h 09m
United Airlines
Fri 11/63:05 pm
BCN
-
TYS
1 stop15h 09m
United Airlines
Deal found 3/3$709

Find flight deals from Knoxville to Spain

Keep the following information in mind while searching for Knoxville to Spain flight deals. Data was last updated March 7, 2026.

Round-trip from

$605
(oojo)

One-way from

$292
(Kiwi.com)

Popular in

June

Cheapest in

January

Average price

$836
From Knoxville McGhee Tyson to Spain
Search Deals
One-way flight from Knoxville McGhee Tyson to Spain
Search Deals
Highest demand for flights based on searches. 28% potential increase in price ($363 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($48 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 7, 2026.
Use the filters below to find and compare flights from Knoxville to Spain that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Tue 4/14

10:49 am-8:05 am

2 stops15h 16m

Madrid Barajas

Tue 4/21

11:15 am-10:34 pm

2 stops17h 19m

$615

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Sat 4/11

5:10 pm-8:20 am

1 stop33h 10m

Madrid Barajas

Sat 4/25

11:45 am-8:18 pm

1 stop14h 33m

$647

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Sat 4/11

6:38 pm-9:40 am

2 stops57h 02m

Madrid Barajas

Sat 4/25

1:35 pm-9:21 pm

1 stop13h 46m

$667

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Sat 4/11

7:20 pm-6:50 am

2 stops29h 30m

Madrid Barajas

Sat 4/25

11:15 am-10:34 pm

2 stops17h 19m

$674

KnoxvilleMálaga

TYS - AGP

TYSAGP

Knoxville McGhee Tyson

Thu 4/16

11:31 am-7:10 pm

2 stops25h 39m

Malaga

Thu 4/23

4:55 pm-9:21 pm

2 stops34h 26m

$688

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Mon 4/20

2:25 pm-8:05 am

1 stop11h 40m

Madrid Barajas

Mon 4/27

12:45 pm-10:34 pm

2 stops39h 49m

$690

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Thu 4/23

9:40 am-8:05 am

1 stop16h 25m

Madrid Barajas

Mon 4/27

12:45 pm-10:34 pm

2 stops39h 49m

$740

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Fri 4/17

5:53 pm-1:15 pm

1 stop13h 22m

Barcelona-El Prat

Fri 5/1

1:15 pm-4:54 pm

2 stops33h 39m

$741

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Wed 4/15

5:15 pm-8:20 am

2 stops33h 05m

Barcelona-El Prat

Fri 4/24

12:15 pm-10:08 am

2 stops51h 53m

$760

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Tue 9/1

6:30 am-8:20 am

2 stops19h 50m

Barcelona-El Prat

Fri 9/11

1:15 pm-4:59 pm

2 stops33h 44m

$800

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/3

Showing 1-10 of 30 resultsSorted by cheapest first
1
2
3

Best time to book a flight from Knoxville to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Spain

What is the cheapest month to book a flight from Knoxville to Spain?

Currently, October is the cheapest month in which you can book a flight from Knoxville to Spain (average of $181). Flying from Knoxville to Spain in June is currently the most expensive (average of $940). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated March 7, 2026.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Spain have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,270 reviews

Crew

8.5

Entertainment

7.8

Boarding

8.1

Overall

7.9

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,270 reviews
Delta
7.9
Good
8,270 reviews

Crew

8.5

Entertainment

7.8

Boarding

8.1

Overall

7.9

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,404 reviews
Delta
7.9
Good
8,270 reviews

Crew

8.5

Entertainment

7.8

Boarding

8.1

Overall

7.9

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,395 reviews
Delta
7.9
Good
8,270 reviews

Crew

8.5

Entertainment

7.8

Boarding

8.1

Overall

7.9

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
British Airways
6.7
Okay
7,778 reviews
Delta
7.9
Good
8,270 reviews

Crew

8.5

Entertainment

7.8

Boarding

8.1

Overall

7.9

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Spain?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Spain. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Spain?

    Airlines like United Airlines, Iberia, and British Airways fly from Knoxville to Spain in about 15h 16m. The time it takes to get you to your destination can typically vary by up to 41h 46m. The distance between Knoxville and Spain is about 4222 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Spain?

    The most popular route from Knoxville to Spain is Knoxville McGhee Tyson - Barcelona-El Prat. You may also consider Knoxville McGhee Tyson - Madrid Barajas or Knoxville McGhee Tyson - Malaga.

  • Can I find deals for flights from Knoxville to Spain that include hotel bookings?

    Yes. In addition to deals on Knoxville to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Spain.

  • Can I find deals for business class flights from Knoxville to Spain?

    Yes. Cheapflights offers flight deals from Knoxville to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Spain?

    Currently, October is the cheapest month in which you can book a flight from Knoxville to Spain (average of $181). Flying from Knoxville to Spain in June is currently the most expensive (average of $940). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 4 airlines flying from Knoxville to Spain

Discover the top 4 airlines that operate flights from Knoxville to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
British AirwaysCheapest$432Average$805FlexibilityNo cancel feeOn-time70%
DeltaCheapest$433Average$1,237FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$512Average$914FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$587Average$796FlexibilityNo cancel feeOn-time69%

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