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$297+ Cheap flights from Knoxville (TYS) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MAD
Feb 20 — Feb 271
Fri 2/20
Fri 2/27
1 adult, Economy
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Cheap flight deals from Knoxville to Spain

Cheapest flights from Knoxville to Spain
Explore the most affordable flight options available from Knoxville to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This oojo deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/95:47 pm
TYS
-
MAD
2 stops19h 43m
British Airways
Mon 3/168:50 pm
MAD
-
TYS
2 stops25h 47m
British Airways
Deal found 1/21$431
This oojo deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:00 am
TYS
-
BCN
2 stops23h 05m
British Airways
Fri 4/247:40 am
BCN
-
TYS
2 stops22h 15m
British Airways
Deal found 1/20$432
This Finnair deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:00 am
TYS
-
BCN
1 stop25h 00m
Multiple Airlines
Fri 4/243:30 pm
BCN
-
TYS
1 stop14h 29m
Multiple Airlines
Deal found 1/21$435
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/155:40 am
TYS
-
BCN
1 stop21h 10m
American Airlines
Tue 2/2412:30 pm
BCN
-
TYS
2 stops17h 29m
American Airlines
Deal found 1/19$439
This FlightHub deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/314:44 pm
TYS
-
BCN
2 stops58h 21m
British Airways
Wed 2/1112:30 pm
BCN
-
TYS
1 stop14h 26m
British Airways
Deal found 1/21$443
This oojo deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:10 am
TYS
-
MAD
2 stops28h 45m
British Airways
Sat 2/281:15 pm
MAD
-
TYS
1 stop13h 52m
British Airways
Deal found 1/20$451
This Finnair deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1812:21 pm
TYS
-
MAD
1 stop15h 04m
Multiple Airlines
Fri 2/2712:55 am
MAD
-
TYS
1 stop20h 42m
Multiple Airlines
Deal found 1/21$464
This oojo deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/285:00 pm
TYS
-
MAD
1 stop30h 45m
British Airways
Sat 3/76:05 pm
MAD
-
TYS
2 stops32h 19m
British Airways
Deal found 1/20$472
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/87:00 am
TYS
-
BCN
2 stops26h 15m
United Airlines
Mon 3/1612:35 pm
BCN
-
TYS
2 stops37h 12m
United Airlines
Deal found 1/21$473
This oojo deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:52 pm
TYS
-
BCN
2 stops16h 38m
British Airways
Sat 11/146:40 am
BCN
-
TYS
2 stops20h 44m
British Airways
Deal found 1/20$482
This Booking.com deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/159:40 am
TYS
-
BCN
2 stops41h 55m
Multiple Airlines
Tue 2/246:50 am
BCN
-
TYS
2 stops19h 47m
Multiple Airlines
Deal found 1/19$483
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:44 am
TYS
-
BCN
1 stop19h 51m
American Airlines
Fri 4/243:30 pm
BCN
-
TYS
1 stop14h 29m
American Airlines
Deal found 1/20$485

Find flight deals from Knoxville to Spain

Keep the following information in mind while searching for Knoxville to Spain flight deals. Data was last updated January 21, 2026.

Round-trip from

$431
(oojo)

One-way from

$297
(Kiwi.com)

Popular in

June

Cheapest in

January

Average price

$483
From Knoxville McGhee Tyson to Spain
Search Deals
One-way flight from Knoxville McGhee Tyson to Spain
Search Deals
Highest demand for flights based on searches. 29% potential increase in price ($380 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($55 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Knoxville to Spain that are best for you.

Fly from

Knoxville

Fly to

Spain

Route

Depart

Return

Price

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Wed 4/15

7:00 am-12:05 pm

2 stops23h 05m

Barcelona-El Prat

Fri 4/24

7:40 am-11:55 pm

2 stops22h 15m

$432

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Wed 4/15

6:00 am-1:00 pm

1 stop25h 00m

Barcelona-El Prat

Fri 4/24

3:30 pm-11:59 pm

1 stop14h 29m

$435

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Mon 3/9

6:10 am-7:55 am

1 stop20h 45m

Madrid Barajas

Mon 3/16

8:50 pm-5:37 pm

2 stops25h 47m

$442

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Wed 2/18

6:10 am-4:55 pm

2 stops28h 45m

Madrid Barajas

Sat 2/28

1:15 pm-9:07 pm

1 stop13h 52m

$451

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Wed 2/18

12:21 pm-9:25 am

1 stop15h 04m

Madrid Barajas

Fri 2/27

12:55 am-3:37 pm

1 stop20h 42m

$464

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Sun 3/8

7:00 am-2:15 pm

2 stops26h 15m

Barcelona-El Prat

Mon 3/16

12:35 pm-8:47 pm

2 stops37h 12m

$473

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Wed 4/15

7:00 am-12:05 pm

2 stops23h 05m

Barcelona-El Prat

Sat 4/25

8:00 pm-4:35 pm

2 stops26h 35m

$482

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Wed 2/4

5:15 pm-10:10 pm

2 stops22h 55m

Madrid Barajas

Sun 2/8

12:40 pm-9:21 pm

1 stop14h 41m

$486

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Mon 3/9

7:25 pm-8:20 am

1 stop31h 55m

Barcelona-El Prat

Mon 3/16

12:35 pm-10:49 am

2 stops27h 14m

$488

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Thu 3/5

9:40 am-4:40 pm

2 stops25h 00m

Madrid Barajas

Fri 3/13

6:00 am-2:50 pm

2 stops37h 50m

$498

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/20

Showing 1-10 of 35 results
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Best time to book a flight from Knoxville to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Spain

What is the cheapest month to book a flight from Knoxville to Spain?

Currently, October is the cheapest month in which you can book a flight from Knoxville to Spain (average of $181). Flying from Knoxville to Spain in June is currently the most expensive (average of $940). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated January 21, 2026.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Spain have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,088 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.8

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,088 reviews
Delta
7.9
Good
8,088 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.8

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,191 reviews
Delta
7.9
Good
8,088 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.8

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,173 reviews
Delta
7.9
Good
8,088 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.8

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
British Airways
6.7
Okay
7,689 reviews
Delta
7.9
Good
8,088 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.8

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Spain?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Spain. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Spain?

    Airlines like British Airways and Delta fly from Knoxville to Spain in about 23h 05m. The time it takes to get you to your destination can typically vary by up to 12m. The distance between Knoxville and Spain is about 4465 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Spain?

    The most popular route from Knoxville to Spain is Knoxville McGhee Tyson - Barcelona-El Prat. You may also consider Knoxville McGhee Tyson - Madrid Barajas or Knoxville McGhee Tyson - Malaga.

  • Can I find deals for flights from Knoxville to Spain that include hotel bookings?

    Yes. In addition to deals on Knoxville to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Spain.

  • Can I find deals for business class flights from Knoxville to Spain?

    Yes. Cheapflights offers flight deals from Knoxville to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Spain?

    Currently, October is the cheapest month in which you can book a flight from Knoxville to Spain (average of $181). Flying from Knoxville to Spain in June is currently the most expensive (average of $940). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Knoxville to Spain

Discover the top 4 airlines that operate flights from Knoxville to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$433Average$1,237FlexibilityNo cancel feeOn-timeN/A
British AirwaysCheapest$483Average$834FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$512Average$997FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$691Average$1,036FlexibilityNo cancel feeOn-time69%

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