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$335+ Cheap flights from Knoxville (TYS) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/19. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MAD
Nov 22 — Nov 291
Sat 11/22
Sat 11/29
1 adult, Economy
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Find flight deals from Knoxville to Spain

Cheapest flights from Knoxville to Spain
Explore the most affordable flight options available from Knoxville to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2025.

This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:40 amTYS - BCN
2 stops20h 20mDelta
Sun 12/710:15 amBCN - TYS
2 stops29h 23mDelta
Deal found 10/21$488
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/212:16 pmTYS - BCN
2 stops35h 34mUnited Airlines
Tue 10/286:45 amBCN - TYS
2 stops22h 14mUnited Airlines
Deal found 10/20$490
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/22:37 pmTYS - MAD
1 stop12h 38mDelta
Sun 12/76:00 amMAD - TYS
2 stops18h 52mDelta
Deal found 10/21$491
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/49:50 amTYS - BCN
2 stops20h 05mUnited Airlines
Thu 11/133:05 pmBCN - TYS
1 stop13h 50mUnited Airlines
Deal found 10/23$503
This Expedia deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/210:54 amTYS - BCN
1 stop16h 06mBritish Airways
Sun 12/712:30 pmBCN - TYS
1 stop14h 28mBritish Airways
Deal found 10/21$509
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/29:40 amTYS - BCN
1 stop16h 40mUnited Airlines
Sun 12/76:50 amBCN - TYS
2 stops20h 14mUnited Airlines
Deal found 10/21$511
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/72:30 pmTYS - MAD
1 stop11h 35mUnited Airlines
Sun 12/145:55 amMAD - TYS
2 stops34h 18mUnited Airlines
Deal found 10/23$512
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/75:54 pmTYS - BCN
2 stops32h 26mUnited Airlines
Sun 12/1410:30 amBCN - TYS
2 stops29h 43mUnited Airlines
Deal found 10/23$513
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/72:58 pmTYS - MAD
1 stop11h 52mMultiple Airlines
Sun 12/141:15 pmMAD - TYS
1 stop13h 43mMultiple Airlines
Deal found 10/23$513
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:37 pmTYS - MAD
1 stop11h 18mAmerican Airlines
Sat 12/612:55 amMAD - TYS
1 stop16h 24mAmerican Airlines
Deal found 10/21$514
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/76:40 amTYS - MAD
1 stop17h 05mAmerican Airlines
Sun 12/141:15 pmMAD - TYS
2 stops15h 43mAmerican Airlines
Deal found 10/23$518
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/67:25 pmTYS - BCN
1 stop30h 55mUnited Airlines
Sat 12/131:55 pmBCN - TYS
2 stops33h 16mUnited Airlines
Deal found 10/22$531

Cheap flight deals from Knoxville to Spain

Keep the following information in mind while searching for Knoxville to Spain flight deals. Data was last updated October 23, 2025.

Round-trip from

$444
(Delta)

One-way from

$335
(Mytrip)

Popular in

June

Cheapest in

February

Average price

$732
From Knoxville McGhee Tyson to Spain
Search Deals
One-way flight from Knoxville McGhee Tyson to Spain
Search Deals
Highest demand for flights based on searches. 25% potential increase in price ($339 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($55 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
Use the filters below to find and compare flights from Knoxville to Spain that are best for you.

Fly from

Knoxville

Fly to

Spain

Route

Depart

Return

Price

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Wed 1/14

5:30 am-8:00 am

2 stops20h 30m

Barcelona-El Prat

Fri 1/23

10:55 am-9:13 am

1 stop28h 18m

$444

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Tue 12/2

5:40 am-8:00 am

2 stops20h 20m

Barcelona-El Prat

Sun 12/7

10:15 am-9:38 am

2 stops29h 23m

$488

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Sat 1/31

12:30 pm-11:10 am

2 stops16h 40m

Barcelona-El Prat

Wed 2/11

10:55 am-11:44 pm

1 stop18h 49m

$488

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Sat 1/31

2:25 pm-9:35 am

2 stops37h 10m

Barcelona-El Prat

Wed 2/11

6:45 am-10:49 am

2 stops34h 04m

$490

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Fri 2/13

12:18 pm-8:50 am

1 stop14h 32m

Barcelona-El Prat

Fri 2/20

10:40 am-11:40 pm

1 stop19h 00m

$501

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Tue 11/4

9:50 am-11:55 am

2 stops20h 05m

Barcelona-El Prat

Thu 11/13

3:05 pm-10:55 pm

1 stop13h 50m

$503

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Sun 12/7

2:30 pm-8:05 am

1 stop11h 35m

Madrid Barajas

Sun 12/14

5:55 am-10:13 am

2 stops34h 18m

$512

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Sun 12/7

6:40 am-5:45 am

1 stop17h 05m

Madrid Barajas

Sun 12/14

1:15 pm-10:58 pm

2 stops15h 43m

$518

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Sat 12/6

7:25 pm-8:05 am

1 stop30h 40m

Madrid Barajas

Sat 12/13

8:25 am-5:11 pm

2 stops38h 46m

$532

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Sun 12/7

5:40 am-8:00 am

2 stops20h 20m

Madrid Barajas

Sun 12/14

6:00 am-8:00 pm

2 stops20h 00m

$571

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/23

Showing 1-10 of 24 results
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Best time to book a flight from Knoxville to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Spain

What is the cheapest month to book a flight from Knoxville to Spain?

Currently, October is the cheapest month in which you can book a flight from Knoxville to Spain (average of $181). Flying from Knoxville to Spain in May is currently the most expensive (average of $1,001). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to ES?

Find hourly flight availability from Knoxville to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 23, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Spain in the evening. If you’re flexible enough to do this you can expect to save up to 21% on your trip compared to booking a flight in the afternoon.

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated October 23, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Spain have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,981 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,981 reviews
Delta
7.9
Good
7,981 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,991 reviews
Delta
7.9
Good
7,981 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,028 reviews
Delta
7.9
Good
7,981 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
British Airways
6.7
Okay
7,467 reviews
Delta
7.9
Good
7,981 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Spain?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Spain. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Spain?

    Airlines like Delta, United Airlines, and American Airlines fly from Knoxville to Spain in about 11h 35m. The time it takes to get you to your destination can typically vary by up to 8h 55m. The distance between Knoxville and Spain is about 4222 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Spain?

    The most popular route from Knoxville to Spain is Knoxville McGhee Tyson - Barcelona-El Prat. You may also consider Knoxville McGhee Tyson - Madrid Barajas or Knoxville McGhee Tyson - Malaga.

  • Can I find deals for flights from Knoxville to Spain that include hotel bookings?

    Yes. In addition to deals on Knoxville to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Spain.

  • Can I find deals for business class flights from Knoxville to Spain?

    Yes. Cheapflights offers flight deals from Knoxville to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Spain?

    Currently, October is the cheapest month in which you can book a flight from Knoxville to Spain (average of $181). Flying from Knoxville to Spain in May is currently the most expensive (average of $1,001). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Knoxville to Spain

Discover the top 4 airlines that operate flights from Knoxville to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$562Average$978FlexibilityNo cancel feeOn-time69%
British AirwaysCheapest$594Average$864FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$631Average$1,161FlexibilityNo cancel feeOn-time71%
DeltaCheapest$830Average$1,276FlexibilityNo cancel feeOn-timeN/A

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