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$356+ Cheap flights from Knoxville (TYS) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MAD
Jul 15 — Jul 221
Wed 7/15
Wed 7/22
1 adult, Economy
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Cheap flight deals from Knoxville to Spain

Cheapest flights from Knoxville to Spain
Explore the most affordable flight options available from Knoxville to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.

This Flighttix deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/41:35 pm
TYS
-
MAD
1 stop12h 30m
Lufthansa
Thu 10/811:15 am
MAD
-
TYS
1 stop15h 04m
Lufthansa
Deal found 6/11$734
This Air France deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:00 pm
TYS
-
AGP
2 stops17h 45m
Multiple Airlines
Wed 10/710:40 am
AGP
-
TYS
2 stops19h 06m
Multiple Airlines
Deal found 6/11$742
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:25 pm
TYS
-
MAD
1 stop30h 40m
United Airlines
Fri 10/161:30 pm
MAD
-
TYS
2 stops37h 30m
United Airlines
Deal found 6/15$744
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:00 pm
TYS
-
BCN
1 stop13h 15m
United Airlines
Fri 10/212:15 pm
BCN
-
TYS
2 stops38h 45m
United Airlines
Deal found 6/13$749
This oojo deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:12 pm
TYS
-
MAD
1 stop29h 23m
British Airways
Fri 10/1612:40 pm
MAD
-
TYS
1 stop16h 50m
British Airways
Deal found 6/11$750
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/410:42 am
TYS
-
MAD
2 stops15h 23m
United Airlines
Thu 10/810:50 am
MAD
-
TYS
2 stops28h 55m
United Airlines
Deal found 6/11$758
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2810:05 am
TYS
-
BCN
2 stops17h 55m
Delta
Fri 11/610:50 am
BCN
-
TYS
1 stop15h 50m
Delta
Deal found 6/15$773
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1310:42 am
TYS
-
BCN
2 stops15h 38m
United Airlines
Tue 10/2011:15 am
BCN
-
TYS
2 stops15h 45m
United Airlines
Deal found 6/11$774
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:25 pm
TYS
-
BCN
1 stop30h 55m
United Airlines
Fri 10/1611:15 am
BCN
-
TYS
1 stop15h 04m
United Airlines
Deal found 6/15$775
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:25 pm
TYS
-
BCN
1 stop32h 35m
United Airlines
Thu 10/293:05 pm
BCN
-
TYS
1 stop30h 44m
United Airlines
Deal found 6/11$780
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:25 pm
TYS
-
MAD
2 stops31h 35m
United Airlines
Sun 10/41:30 pm
MAD
-
TYS
2 stops37h 30m
United Airlines
Deal found 6/14$793
This Iberia deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/268:15 pm
TYS
-
MAD
1 stop30h 05m
Iberia
Sun 10/411:45 am
MAD
-
TYS
1 stop13h 58m
Iberia
Deal found 6/14$809

Find flight deals from Knoxville to Spain

Keep the following information in mind while searching for Knoxville to Spain flight deals. Data was last updated June 15, 2026.

Round-trip from

$734
(Flighttix)

One-way from

$356
(oojo)

Popular in

May

Cheapest in

January
From Knoxville McGhee Tyson to Spain
Search Deals
One-way flight from Knoxville McGhee Tyson to Spain
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($231 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($55 potential savings vs. average RT price).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from Knoxville to Spain that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleMálaga

TYS - AGP

TYSAGP

Knoxville McGhee Tyson

Wed 9/30

12:00 pm-11:45 am

2 stops17h 45m

Malaga

Wed 10/7

10:40 am-11:46 pm

2 stops19h 06m

$742

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Sat 10/10

7:25 pm-8:05 am

1 stop30h 40m

Madrid Barajas

Fri 10/16

1:30 pm-9:00 pm

2 stops37h 30m

$744

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Wed 9/23

6:00 pm-1:15 pm

1 stop13h 15m

Barcelona-El Prat

Fri 10/2

11:15 am-11:59 pm

1 stop18h 44m

$769

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Sun 12/6

10:16 am-9:00 am

1 stop16h 44m

Barcelona-El Prat

Wed 12/9

6:50 am-9:05 pm

2 stops20h 15m

$772

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Wed 10/28

7:20 pm-2:55 pm

2 stops14h 35m

Barcelona-El Prat

Fri 11/6

10:50 am-11:46 pm

1 stop18h 56m

$773
Quickest round-trip

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Tue 10/13

10:42 am-8:20 am

2 stops15h 38m

Barcelona-El Prat

Tue 10/20

11:15 am-9:00 pm

2 stops15h 45m

$774

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Sat 10/10

7:25 pm-8:20 am

1 stop30h 55m

Barcelona-El Prat

Fri 10/16

11:15 am-8:19 pm

1 stop15h 04m

$775

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Wed 10/28

7:20 pm-5:05 pm

2 stops16h 45m

Barcelona-El Prat

Fri 11/6

10:30 am-9:45 pm

2 stops17h 15m

$778

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Sat 10/24

7:25 pm-10:00 am

1 stop32h 35m

Barcelona-El Prat

Thu 10/29

3:05 pm-4:49 pm

1 stop30h 44m

$780

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Sat 9/26

7:25 pm-9:00 am

2 stops31h 35m

Madrid Barajas

Sun 10/4

1:30 pm-9:00 pm

2 stops37h 30m

$793

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Showing 1-10 of 25 resultsSorted by cheapest first
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Best time to book a flight from Knoxville to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Spain

What is the cheapest month to book a flight from Knoxville to Spain?

Currently, March is the cheapest month in which you can book a flight from Knoxville to Spain (average of $432). Flying from Knoxville to Spain in June is currently the most expensive (average of $1,474). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated June 15, 2026.
See what other customers who have flown with United Airlines,American Airlines, andBritish Airways from Knoxville to Spain have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,831 reviews

Comfort

7.3

Crew

8.1

Entertainment

7.1

Boarding

7.7

Overall

7.4

Food

6.6

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.
United Airlines
7.4
Good
9,831 reviews
United Airlines
7.4
Good
9,831 reviews

Comfort

7.3

Crew

8.1

Entertainment

7.1

Boarding

7.7

Overall

7.4

Food

6.6

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.
American Airlines
7.1
Good
11,660 reviews
United Airlines
7.4
Good
9,831 reviews

Comfort

7.3

Crew

8.1

Entertainment

7.1

Boarding

7.7

Overall

7.4

Food

6.6

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.
British Airways
6.7
Okay
8,050 reviews
United Airlines
7.4
Good
9,831 reviews

Comfort

7.3

Crew

8.1

Entertainment

7.1

Boarding

7.7

Overall

7.4

Food

6.6

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Spain?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Spain. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Spain?

    Airlines like United Airlines, Scandinavian Airlines, and Lufthansa fly from Knoxville to Spain in about 19h 45m. The time it takes to get you to your destination can typically vary by up to 10h 55m. The distance between Knoxville and Spain is about 4288 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Spain?

    The most popular route from Knoxville to Spain is Knoxville McGhee Tyson - Barcelona-El Prat. You may also consider Knoxville McGhee Tyson - Madrid Barajas or Knoxville McGhee Tyson - Malaga.

  • Can I find deals for flights from Knoxville to Spain that include hotel bookings?

    Yes. In addition to deals on Knoxville to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Spain.

  • Can I find deals for business class flights from Knoxville to Spain?

    Yes. Cheapflights offers flight deals from Knoxville to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Spain?

    Currently, March is the cheapest month in which you can book a flight from Knoxville to Spain (average of $432). Flying from Knoxville to Spain in June is currently the most expensive (average of $1,474). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Knoxville to Spain

Discover the top 3 airlines that operate flights from Knoxville to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
British AirwaysCheapest$432Average$795FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$586Average$929FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$664Average$835FlexibilityNo cancel feeOn-time69%

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