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$445+ Cheap flights from Knoxville (TYS) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/19. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MAD
May 18 — May 251
Mon 5/18
Mon 5/25
1 adult, Economy
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Cheap flight deals from Knoxville to Spain

Cheapest flights from Knoxville to Spain
Explore the most affordable flight options available from Knoxville to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 18, 2026.

This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/294:00 pm
TYS
-
MAD
1 stop14h 15m
Delta
Thu 12/310:00 am
MAD
-
TYS
1 stop16h 35m
Delta
Deal found 4/13$754
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:20 pm
TYS
-
MAD
1 stop10h 55m
Delta
Thu 12/36:00 am
MAD
-
TYS
2 stops18h 13m
Delta
Deal found 4/13$756
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3011:30 am
TYS
-
MAD
2 stops12h 50m
Delta
Thu 12/310:00 am
MAD
-
TYS
2 stops17h 45m
Delta
Deal found 4/13$758
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/128:47 am
TYS
-
MAD
1 stop21h 28m
Delta
Tue 10/2710:00 am
MAD
-
TYS
2 stops18h 46m
Delta
Deal found 4/17$759
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:35 pm
TYS
-
MAD
1 stop30h 30m
United Airlines
Fri 11/276:00 am
MAD
-
TYS
2 stops19h 17m
United Airlines
Deal found 4/13$760
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/157:20 pm
TYS
-
MAD
2 stops16h 20m
Delta
Thu 12/36:00 am
MAD
-
TYS
2 stops20h 40m
Delta
Deal found 4/17$761
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/92:20 pm
TYS
-
MAD
2 stops12h 55m
United Airlines
Wed 11/111:35 pm
MAD
-
TYS
2 stops16h 02m
United Airlines
Deal found 4/15$762
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/287:20 pm
TYS
-
MAD
1 stop10h 55m
Delta
Fri 11/276:00 am
MAD
-
TYS
2 stops23h 46m
Delta
Deal found 4/13$763
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3010:05 am
TYS
-
MAD
2 stops14h 15m
Delta
Fri 11/276:00 am
MAD
-
TYS
2 stops23h 46m
Delta
Deal found 4/13$767
This Finnair deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:07 pm
TYS
-
BCN
1 stop13h 58m
Multiple Airlines
Wed 11/113:05 pm
BCN
-
TYS
1 stop14h 40m
Multiple Airlines
Deal found 4/13$769
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:00 pm
TYS
-
BCN
1 stop18h 10m
United Airlines
Fri 11/610:30 am
BCN
-
TYS
1 stop14h 47m
United Airlines
Deal found 4/16$770
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/281:40 pm
TYS
-
BCN
1 stop14h 10m
American Airlines
Fri 11/611:00 am
BCN
-
TYS
1 stop18h 45m
American Airlines
Deal found 4/14$771

Find flight deals from Knoxville to Spain

Keep the following information in mind while searching for Knoxville to Spain flight deals. Data was last updated April 18, 2026.

Round-trip from

$754
(United Airlines)

One-way from

$445
(Kiwi.com)

Popular in

June

Cheapest in

January

Average price

$815
From Knoxville McGhee Tyson to Spain
Search Deals
One-way flight from Knoxville McGhee Tyson to Spain
Search Deals
Highest demand for flights based on searches. 30% potential increase in price ($383 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($52 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
Use the filters below to find and compare flights from Knoxville to Spain that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Sun 10/4

4:00 pm-12:15 pm

1 stop14h 15m

Madrid Barajas

Wed 10/14

6:00 am-9:45 pm

2 stops21h 45m

$756

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Wed 9/23

10:00 am-8:00 am

2 stops16h 00m

Barcelona-El Prat

Fri 10/2

1:15 pm-2:42 pm

2 stops31h 27m

$786

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Wed 9/23

6:21 am-7:35 am

1 stop19h 14m

Barcelona-El Prat

Fri 10/2

10:15 am-9:15 pm

2 stops17h 00m

$803

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Fri 10/2

6:10 am-6:20 am

2 stops18h 10m

Madrid Barajas

Fri 11/27

6:00 am-11:46 pm

2 stops23h 46m

$817

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Sun 9/6

4:00 pm-12:50 pm

1 stop14h 50m

Barcelona-El Prat

Tue 9/15

11:00 am-11:47 pm

1 stop18h 47m

$837
Quickest round-trip

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Mon 9/28

7:20 pm-12:15 pm

1 stop10h 55m

Madrid Barajas

Tue 12/1

11:55 am-9:45 pm

1 stop15h 50m

$840

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Mon 8/3

6:30 am-8:20 am

2 stops19h 50m

Barcelona-El Prat

Fri 8/21

11:15 am-8:48 pm

2 stops15h 33m

$841

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Tue 9/8

5:45 am-8:05 am

1 stop20h 20m

Madrid Barajas

Fri 9/25

11:15 am-2:42 pm

1 stop33h 27m

$845

KnoxvilleMadrid

TYS - MAD

TYSMAD

Knoxville McGhee Tyson

Mon 8/3

5:45 am-6:50 am

2 stops19h 05m

Madrid Barajas

Wed 8/19

5:55 am-8:28 pm

2 stops20h 33m

$845

KnoxvilleBarcelona

TYS - BCN

TYSBCN

Knoxville McGhee Tyson

Tue 9/1

7:19 pm-8:00 am

2 stops30h 41m

Barcelona-El Prat

Fri 9/11

3:15 pm-12:25 am

1 stop15h 10m

$846

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/15

Showing 1-10 of 25 resultsSorted by cheapest first
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2
3

Best time to book a flight from Knoxville to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Spain

What is the cheapest month to book a flight from Knoxville to Spain?

Currently, March is the cheapest month in which you can book a flight from Knoxville to Spain (average of $432). Flying from Knoxville to Spain in June is currently the most expensive (average of $1,121). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated April 18, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Knoxville to Spain have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,422 reviews

Food

7.2

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,422 reviews
Delta
7.9
Good
8,422 reviews

Food

7.2

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,605 reviews
Delta
7.9
Good
8,422 reviews

Food

7.2

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,617 reviews
Delta
7.9
Good
8,422 reviews

Food

7.2

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
British Airways
6.7
Okay
7,892 reviews
Delta
7.9
Good
8,422 reviews

Food

7.2

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Spain?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Spain. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Spain?

    Airlines like Delta, United Airlines, and British Airways fly from Knoxville to Spain in about 14h 15m. The time it takes to get you to your destination can typically vary by up to 4h 59m. The distance between Knoxville and Spain is about 4222 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Knoxville to Spain?

    The most popular route from Knoxville to Spain is Knoxville McGhee Tyson - Barcelona-El Prat. You may also consider Knoxville McGhee Tyson - Madrid Barajas or Knoxville McGhee Tyson - Malaga.

  • Can I find deals for flights from Knoxville to Spain that include hotel bookings?

    Yes. In addition to deals on Knoxville to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Spain.

  • Can I find deals for business class flights from Knoxville to Spain?

    Yes. Cheapflights offers flight deals from Knoxville to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Spain?

    Currently, March is the cheapest month in which you can book a flight from Knoxville to Spain (average of $432). Flying from Knoxville to Spain in June is currently the most expensive (average of $1,121). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 4 airlines flying from Knoxville to Spain

Discover the top 4 airlines that operate flights from Knoxville to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
AirlineCheapestAverageFlexibilityOn-time
British AirwaysCheapest$432Average$795FlexibilityNo cancel feeOn-time70%
DeltaCheapest$433Average$1,113FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$512Average$918FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$587Average$813FlexibilityNo cancel feeOn-time69%

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