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South Carolina

$61+ Cheap flights from Milwaukee (MKE) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/7. Fares are subject to change and may not be available on all flights or dates of travel.
MKE — CHS
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Cheap flight deals from Milwaukee to South Carolina

Keep the following information in mind while searching for Milwaukee to South Carolina flight deals. Data was last updated November 6, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$168
(Frontier)

One-way from

$61
(Frontier)

Popular in

March

Cheapest in

January

Average price

$322
Provider with most accurate pricing for Milwaukee-Mitchell-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Milwaukee-Mitchell-Myrtle Beach Intl flights.
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From Milwaukee-Mitchell to South Carolina
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One-way flight from Milwaukee-Mitchell to South Carolina
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Highest demand for flights based on searches. 8% potential increase in price ($33 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Milwaukee to South Carolina

Cheapest flights from Milwaukee to South Carolina
Explore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/810:34 amMKE - CLT
1 stop22h 16mMultiple Airlines
Thu 12/113:07 pmCLT - MKE
2 stops19h 32mMultiple Airlines
Deal found 11/6$229
This Mytrip deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2312:35 pmMKE - MYR
1 stop6h 28mSpirit Airlines
Thu 12/118:27 pmMYR - MKE
1 stop14h 12mSpirit Airlines
Deal found 11/6$241
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2012:35 pmMKE - CLT
1 stop6h 22mMultiple Airlines
Sun 11/238:54 amCLT - MKE
1 stop10h 54mMultiple Airlines
Deal found 11/6$243
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:15 pmMKE - CLT
1 stop23h 14mMultiple Airlines
Mon 12/299:43 pmCLT - MKE
1 stop22h 37mMultiple Airlines
Deal found 11/6$245
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/411:41 amMKE - CAE
1 stop6h 22mDelta
Sun 12/75:34 amCAE - MKE
1 stop4h 54mDelta
Deal found 11/5$249
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:29 amMKE - HHH
1 stop5h 01mAmerican Airlines
Sat 12/611:47 amHHH - MKE
1 stop7h 17mAmerican Airlines
Deal found 11/4$249
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/188:15 pmMKE - CLT
1 stop16h 41mMultiple Airlines
Mon 12/229:43 pmCLT - MKE
1 stop22h 37mMultiple Airlines
Deal found 11/6$255
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/207:00 amMKE - CAE
1 stop6h 08mDelta
Mon 11/245:37 amCAE - MKE
1 stop4h 51mDelta
Deal found 11/5$264
This Mytrip deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/410:34 amMKE - CLT
1 stop8h 26mSpirit Airlines
Thu 12/1112:59 pmCLT - MKE
2 stops21h 40mSpirit Airlines
Deal found 11/5$265
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/165:30 amMKE - CLT
1 stop5h 50mSouthwest
Thu 12/186:55 pmCLT - MKE
1 stop5h 30mSouthwest
Deal found 11/5$267
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/410:34 amMKE - CLT
1 stop10h 04mMultiple Airlines
Thu 12/113:07 pmCLT - MKE
2 stops27h 02mMultiple Airlines
Deal found 11/5$268
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/45:00 amMKE - CAE
2 stops6h 31mAmerican Airlines
Sun 12/78:11 pmCAE - MKE
1 stop4h 50mAmerican Airlines
Deal found 11/5$269

Cheapflights Fare Finder

 
Customize your flight search to find flights from Milwaukee to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Milwaukee to South Carolina that are best for you.

Fly from

Milwaukee

Fly to

South Carolina

Route

Depart

Return

Price

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Mon 12/8

10:34 am-9:50 am

1 stop22h 16m

Charlotte Douglas

Thu 12/11

3:07 pm-9:39 am

2 stops19h 32m

$229

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Wed 1/14

12:11 pm-7:27 pm

1 stop6h 16m

Columbia Metropolitan

Mon 1/19

5:06 pm-7:58 pm

1 stop3h 52m

$249

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Thu 12/4

11:57 am-6:47 pm

1 stop5h 50m

Columbia Metropolitan

Sun 12/7

8:11 pm-12:01 am

1 stop4h 50m

$249

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Tue 1/13

5:20 am-12:00 pm

1 stop5h 40m

Columbia Metropolitan

Mon 1/19

5:06 pm-7:58 pm

1 stop3h 52m

$249

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Tue 1/13

6:12 am-11:34 am

1 stop4h 22m

Columbia Metropolitan

Sat 1/17

11:59 am-3:20 pm

1 stop4h 21m

$249

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Sat 3/7

6:29 pm-11:48 pm

1 stop4h 19m

Columbia Metropolitan

Wed 3/11

5:40 am-9:27 am

1 stop4h 47m

$249

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Wed 1/14

5:20 am-12:00 pm

1 stop5h 40m

Columbia Metropolitan

Sun 1/18

5:35 am-11:09 am

1 stop6h 34m

$249

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Tue 1/13

12:11 pm-7:27 pm

1 stop6h 16m

Columbia Metropolitan

Sat 1/17

12:45 pm-4:29 pm

1 stop4h 44m

$249

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Thu 12/4

11:41 am-7:03 pm

1 stop6h 22m

Columbia Metropolitan

Sun 12/7

5:34 am-9:28 am

1 stop4h 54m

$249

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Fri 2/27

3:57 pm-9:48 pm

1 stop4h 51m

Columbia Metropolitan

Sun 3/1

6:40 am-11:15 am

1 stop5h 35m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Showing 1-10 of 60 results
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Best time to book a flight from Milwaukee to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Milwaukee with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Milwaukee to South Carolina

What is the cheapest month to book a flight from Milwaukee to South Carolina?

Currently, July is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $60). Flying from Milwaukee to South Carolina in December is currently the most expensive (average of $198). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MKE to SC?

Find hourly flight availability from Milwaukee to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

It’s typically best to fly out from Milwaukee to South Carolina in the evening. Doing so could potentially save you 32% on the flight price compared to flying at noon, which is usually more expensive.

What is the cheapest day to fly from Milwaukee to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Milwaukee to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Milwaukee to South Carolina flight should consider departing on Friday evenings when fares are most often at their lowest. Saturday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 6, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Milwaukee to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Entertainment

7.5

Food

7.0

Comfort

8.0

Crew

8.6

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Entertainment

7.5

Food

7.0

Comfort

8.0

Crew

8.6

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
8,001 reviews
Southwest
8.0
Very good
4,241 reviews

Entertainment

7.5

Food

7.0

Comfort

8.0

Crew

8.6

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
9,007 reviews
Southwest
8.0
Very good
4,241 reviews

Entertainment

7.5

Food

7.0

Comfort

8.0

Crew

8.6

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,040 reviews
Southwest
8.0
Very good
4,241 reviews

Entertainment

7.5

Food

7.0

Comfort

8.0

Crew

8.6

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Spirit Airlines
6.3
Okay
8,122 reviews
Southwest
8.0
Very good
4,241 reviews

Entertainment

7.5

Food

7.0

Comfort

8.0

Crew

8.6

Boarding

8.1

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Milwaukee to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Milwaukee to South Carolina?

    Milwaukee-Mitchell (MKE), located 6.4 mi from the city center, is the airport you fly out of when you book flights from Milwaukee to South Carolina.

  • How long is the flight from Milwaukee to South Carolina?

    Delta, Southwest, and United Airlines can get you from Milwaukee to South Carolina in just under 5h 02m. Your travel time can differ by up to 1h 14m. There are 831 mi between Milwaukee and South Carolina. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Milwaukee to South Carolina one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $61. Users have also found prices from $135 and $157 on Spirit Airlines and Delta, respectively.

  • What are the most popular routes from Milwaukee to South Carolina?

    While some choose either Milwaukee-Mitchell - Charleston or Milwaukee-Mitchell - Myrtle Beach Intl, Milwaukee-Mitchell - Charlotte Douglas is the most popular route from Milwaukee to South Carolina.

  • Can I find deals for flights from Milwaukee to South Carolina that include hotel bookings?

    Yes. In addition to deals on Milwaukee to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Milwaukee to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Milwaukee to South Carolina.

  • Can I find deals for business class flights from Milwaukee to South Carolina?

    Yes. Cheapflights offers flight deals from Milwaukee to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Milwaukee to South Carolina?

    Currently, July is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $60). Flying from Milwaukee to South Carolina in December is currently the most expensive (average of $198). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Milwaukee to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Milwaukee to South Carolina

Discover the top 5 airlines that operate flights from Milwaukee to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$141Average$239FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$228Average$374FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$360FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$409FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$256Average$400FlexibilityNo cancel feeOn-time63%

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