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South Carolina

$115+ Cheap flights from Milwaukee (MKE) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/17. Fares are subject to change and may not be available on all flights or dates of travel.
MKE — CHS
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Milwaukee to South Carolina

Keep the following information in mind while searching for Milwaukee to South Carolina flight deals. Data was last updated September 17, 2025.

Round-trip from

$211
(American Airlines)

One-way from

$115
(American Airlines)

Popular in

March

Cheapest in

October

Average price

$351
From Milwaukee-Mitchell to South Carolina
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One-way flight from Milwaukee-Mitchell to South Carolina
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Highest demand for flights based on searches. 7% potential increase in price ($29 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Milwaukee to South Carolina

Cheapest flights from Milwaukee to South Carolina
Explore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/148:00 amMKE - CLT
Nonstop2h 06mAmerican Airlines
Tue 10/142:24 pmCLT - MKE
1 stop10h 06mAmerican Airlines
Deal found 9/15$211
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1412:31 pmMKE - SAV
1 stop8h 03mAmerican Airlines
Mon 11/173:01 pmSAV - MKE
1 stop9h 41mAmerican Airlines
Deal found 9/15$219
This Frontier deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:04 pmMKE - CLT
2 stops10h 49mFrontier
Sun 10/1910:05 pmCLT - MKE
2 stops22h 13mFrontier
Deal found 9/15$242
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/132:53 pmMKE - SAV
1 stop5h 23mAmerican Airlines
Tue 11/1811:08 amSAV - MKE
1 stop13h 34mAmerican Airlines
Deal found 9/15$248
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/910:35 amMKE - CAE
1 stop5h 02mDelta
Sun 10/127:55 pmCAE - MKE
1 stop5h 00mDelta
Deal found 9/15$249
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:14 amMKE - HHH
1 stop7h 05mAmerican Airlines
Wed 11/127:07 pmHHH - MKE
1 stop4h 49mAmerican Airlines
Deal found 9/14$249
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/156:00 amMKE - CAE
2 stops7h 18mUnited Airlines
Wed 10/225:26 pmCAE - MKE
1 stop5h 30mUnited Airlines
Deal found 9/15$254
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/119:39 amMKE - CLT
1 stop5h 16mDelta
Wed 10/156:45 amCLT - MKE
1 stop5h 16mDelta
Deal found 9/15$257
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/147:35 amMKE - SAV
1 stop6h 50mSouthwest
Tue 10/217:35 pmSAV - MKE
1 stop3h 50mSouthwest
Deal found 9/16$257
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/252:36 pmMKE - CAE
2 stops8h 30mAmerican Airlines
Sat 11/12:35 pmCAE - MKE
2 stops6h 11mAmerican Airlines
Deal found 9/17$259
This Frontier deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/248:04 pmMKE - CLT
2 stops10h 49mFrontier
Sun 10/2610:05 pmCLT - MKE
2 stops22h 13mFrontier
Deal found 9/15$265
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/47:00 amMKE - SAV
1 stop7h 59mDelta
Thu 11/68:17 amSAV - MKE
1 stop5h 52mDelta
Deal found 9/15$267

Cheapflights Fare Finder

 
Customize your flight search to find flights from Milwaukee to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Milwaukee to South Carolina that are best for you.

Fly from

Milwaukee

Fly to

South Carolina

Route

Depart

Return

Price

MilwaukeeSavannah

MKE - SAV

MKESAV

Milwaukee-Mitchell

Fri 11/14

12:31 pm-9:34 pm

1 stop8h 03m

Savannah/Hilton Head

Mon 11/17

3:01 pm-11:42 pm

1 stop9h 41m

$219

MilwaukeeSavannah

MKE - SAV

MKESAV

Milwaukee-Mitchell

Thu 11/13

2:53 pm-9:16 pm

1 stop5h 23m

Savannah/Hilton Head

Tue 11/18

11:08 am-11:42 pm

1 stop13h 34m

$248

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Wed 10/29

1:25 pm-9:20 pm

1 stop6h 55m

Columbia Metropolitan

Sat 11/8

5:32 pm-8:42 pm

1 stop4h 10m

$249

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Sat 10/25

6:00 am-1:45 pm

1 stop6h 45m

Columbia Metropolitan

Sat 11/1

5:24 pm-10:43 pm

1 stop6h 19m

$249

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Thu 10/9

12:06 pm-7:02 pm

1 stop5h 56m

Columbia Metropolitan

Sun 10/12

7:55 pm-11:55 pm

1 stop5h 00m

$249

MilwaukeeHilton Head Island

MKE - HHH

MKEHHH

Milwaukee-Mitchell

Sat 11/8

6:14 am-2:19 pm

1 stop7h 05m

Hilton Head Island

Wed 11/12

7:07 pm-10:56 pm

1 stop4h 49m

$249

MilwaukeeHilton Head Island

MKE - HHH

MKEHHH

Milwaukee-Mitchell

Tue 2/3

7:17 am-2:18 pm

1 stop6h 01m

Hilton Head Island

Mon 2/9

6:14 pm-9:25 pm

1 stop4h 11m

$249

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Wed 10/15

6:00 am-2:18 pm

2 stops7h 18m

Columbia Metropolitan

Wed 10/22

5:26 pm-9:56 pm

1 stop5h 30m

$254

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Wed 10/29

6:05 am-2:15 pm

2 stops7h 10m

Columbia Metropolitan

Sat 11/8

5:24 pm-8:50 pm

1 stop4h 26m

$254

MilwaukeeSavannah

MKE - SAV

MKESAV

Milwaukee-Mitchell

Tue 10/14

7:35 am-3:25 pm

1 stop6h 50m

Savannah/Hilton Head

Tue 10/21

7:35 pm-10:25 pm

1 stop3h 50m

$257

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 60 results
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Best time to book a flight from Milwaukee to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Milwaukee with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Milwaukee to South Carolina

What is the cheapest month to book a flight from Milwaukee to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $217). Flying from Milwaukee to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MKE to SC?

Find hourly flight availability from Milwaukee to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

When flying from Milwaukee to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Milwaukee to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 17, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Milwaukee to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,961 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,926 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Spirit Airlines
6.3
Okay
8,023 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Milwaukee to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Milwaukee to South Carolina?

    Milwaukee-Mitchell (MKE), located 6.4 mi from the city center, is the airport you fly out of when you book flights from Milwaukee to South Carolina.

  • How long is the flight from Milwaukee to South Carolina?

    American Airlines, Delta, and United Airlines can get you from Milwaukee to South Carolina in just under 6h 45m. Your travel time can differ by up to 1h 18m. There are 721 mi between Milwaukee and South Carolina. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Milwaukee to South Carolina one-way?

    For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $115. Users have also found prices from $129 and $129 on Delta and Southwest, respectively.

  • What are the most popular routes from Milwaukee to South Carolina?

    While some choose either Milwaukee-Mitchell - Savannah/Hilton Head or Milwaukee-Mitchell - Charleston, Milwaukee-Mitchell - Charlotte Douglas is the most popular route from Milwaukee to South Carolina.

  • Can I find deals for flights from Milwaukee to South Carolina that include hotel bookings?

    Yes. In addition to deals on Milwaukee to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Milwaukee to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Milwaukee to South Carolina.

  • Can I find deals for business class flights from Milwaukee to South Carolina?

    Yes. Cheapflights offers flight deals from Milwaukee to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Milwaukee to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $217). Flying from Milwaukee to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Milwaukee to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Milwaukee to South Carolina

Discover the top 5 airlines that operate flights from Milwaukee to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$141Average$241FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$228Average$379FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$370FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$256Average$393FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$280Average$401FlexibilityNo cancel feeOn-time69%

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