HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$108+ Cheap flights from Milwaukee (MKE) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/18. Fares are subject to change and may not be available on all flights or dates of travel.
MKE — CHS
Aug 23 — Aug 301
Sat 8/23
Sat 8/30
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Milwaukee to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Milwaukee to South Carolina

Keep the following information in mind while searching for Milwaukee to South Carolina flight deals. Data was last updated August 18, 2025.

Round-trip from

$229
(Delta)

One-way from

$108
(Kiwi.com)

Popular in

March

Cheapest in

October

Average price

$364
From Milwaukee-Mitchell to South Carolina
Search Deals
One-way flight from Milwaukee-Mitchell to South Carolina
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($34 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2025
Search Deals

Find flight deals from Milwaukee to South Carolina

Cheapest flights from Milwaukee to South Carolina
Explore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.

This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/176:00 amMKE - CAE
1 stop8h 05mDelta
Wed 9/245:40 amCAE - MKE
1 stop6h 27mDelta
Deal found 8/17$229
This FlightHub deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1311:57 amMKE - CLT
1 stop25h 51mMultiple Airlines
Sun 11/166:07 pmCLT - MKE
1 stop26h 12mMultiple Airlines
Deal found 8/17$233
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:45 amMKE - CAE
2 stops6h 20mAmerican Airlines
Wed 10/296:48 pmCAE - MKE
1 stop5h 28mAmerican Airlines
Deal found 8/15$234
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:16 amMKE - CLT
1 stop9h 45mAmerican Airlines
Fri 10/317:20 pmCLT - MKE
Nonstop2h 07mAmerican Airlines
Deal found 8/16$241
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/64:19 pmMKE - SAV
1 stop6h 40mAmerican Airlines
Sat 10/188:37 pmSAV - MKE
1 stop4h 37mAmerican Airlines
Deal found 8/17$251
This FlightHub deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/3012:42 pmMKE - CLT
1 stop18h 05mMultiple Airlines
Sun 11/26:07 pmCLT - MKE
1 stop26h 12mMultiple Airlines
Deal found 8/17$253
This FlightHub deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1812:53 pmMKE - CLT
1 stop23h 00mMultiple Airlines
Sun 9/215:20 pmCLT - MKE
1 stop26h 59mMultiple Airlines
Deal found 8/18$259
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/48:00 amMKE - SAV
2 stops5h 53mAmerican Airlines
Tue 10/286:20 amSAV - MKE
2 stops7h 53mAmerican Airlines
Deal found 8/16$261
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1812:20 pmMKE - SAV
1 stop4h 45mSouthwest
Mon 9/227:00 pmSAV - MKE
1 stop5h 00mSouthwest
Deal found 8/18$264
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/145:22 pmMKE - GSP
1 stop3h 56mDelta
Sat 10/187:05 amGSP - MKE
1 stop4h 56mDelta
Deal found 8/17$266
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/212:42 pmMKE - CLT
1 stop19h 20mMultiple Airlines
Wed 11/57:59 pmCLT - MKE
1 stop16h 03mMultiple Airlines
Deal found 8/18$268
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/278:10 amMKE - CAE
1 stop5h 39mAmerican Airlines
Sat 8/303:23 pmCAE - MKE
1 stop7h 35mAmerican Airlines
Deal found 8/16$268

Cheapflights Fare Finder

 
Customize your flight search to find flights from Milwaukee to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Milwaukee to South Carolina that are best for you.

Fly from

Milwaukee

Fly to

South Carolina

Route

Depart

Return

Price

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Sat 10/25

5:59 pm-11:37 pm

1 stop4h 38m

Columbia Metropolitan

Wed 10/29

6:00 am-12:29 pm

1 stop7h 29m

$229

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Thu 9/18

5:40 am-12:37 pm

1 stop5h 57m

Columbia Metropolitan

Sun 9/21

6:47 am-11:07 am

1 stop5h 20m

$229

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Wed 9/17

6:00 am-3:05 pm

1 stop8h 05m

Columbia Metropolitan

Wed 9/24

5:40 am-11:07 am

1 stop6h 27m

$229

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Thu 11/13

11:57 am-2:48 pm

1 stop25h 51m

Charlotte Douglas

Sun 11/16

6:07 pm-7:19 pm

1 stop26h 12m

$233

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Sat 10/25

6:45 am-2:05 pm

2 stops6h 20m

Columbia Metropolitan

Wed 10/29

6:48 pm-11:16 pm

1 stop5h 28m

$234

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Fri 10/31

6:16 am-5:01 pm

1 stop9h 45m

Charlotte Douglas

Fri 10/31

7:20 pm-8:27 pm

Nonstop2h 07m

$241

MilwaukeeSavannah

MKE - SAV

MKESAV

Milwaukee-Mitchell

Thu 9/11

2:45 pm-7:42 pm

1 stop3h 57m

Savannah/Hilton Head

Sun 9/14

8:37 pm-12:09 am

1 stop4h 32m

$251

MilwaukeeSavannah

MKE - SAV

MKESAV

Milwaukee-Mitchell

Tue 11/4

3:25 pm-10:31 pm

1 stop6h 06m

Savannah/Hilton Head

Thu 11/6

8:29 pm-11:59 pm

1 stop4h 30m

$251

MilwaukeeSavannah

MKE - SAV

MKESAV

Milwaukee-Mitchell

Sat 10/4

3:47 pm-11:01 pm

1 stop6h 14m

Savannah/Hilton Head

Tue 10/28

7:36 am-1:13 pm

1 stop6h 37m

$251

MilwaukeeSavannah

MKE - SAV

MKESAV

Milwaukee-Mitchell

Mon 10/6

4:19 pm-11:59 pm

1 stop6h 40m

Savannah/Hilton Head

Sat 10/18

8:37 pm-12:14 am

1 stop4h 37m

$251

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/16

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Milwaukee to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Milwaukee with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Milwaukee to South Carolina

What is the cheapest month to book a flight from Milwaukee to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $217). Flying from Milwaukee to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MKE to SC?

Find hourly flight availability from Milwaukee to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 18, 2025.

When flying from Milwaukee to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated August 18, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Milwaukee to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,246 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Food

7.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,246 reviews
Southwest
8.0
Very good
4,246 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Food

7.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
8.0
Very good
7,981 reviews
Southwest
8.0
Very good
4,246 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Food

7.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
8,925 reviews
Southwest
8.0
Very good
4,246 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Food

7.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,246 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Food

7.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Spirit Airlines
6.3
Okay
8,038 reviews
Southwest
8.0
Very good
4,246 reviews

Crew

8.6

Boarding

8.1

Comfort

8.0

Food

7.0

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Milwaukee to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Milwaukee to South Carolina?

    Milwaukee-Mitchell (MKE), located 6.4 mi from the city center, is the airport you fly out of when you book flights from Milwaukee to South Carolina.

  • How long is the flight from Milwaukee to South Carolina?

    Delta and American Airlines can get you from Milwaukee to South Carolina in just under 4h 38m. Your travel time can differ by up to 1h 42m. There are 721 mi between Milwaukee and South Carolina. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Milwaukee to South Carolina one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $123. Users have also found prices from $126 and $139 on American Airlines and United Airlines, respectively.

  • What are the most popular routes from Milwaukee to South Carolina?

    While some choose either Milwaukee-Mitchell - Charleston or Milwaukee-Mitchell - Savannah/Hilton Head, Milwaukee-Mitchell - Charlotte Douglas is the most popular route from Milwaukee to South Carolina.

  • Can I find deals for flights from Milwaukee to South Carolina that include hotel bookings?

    Yes. In addition to deals on Milwaukee to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Milwaukee to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Milwaukee to South Carolina.

  • Can I find deals for business class flights from Milwaukee to South Carolina?

    Yes. Cheapflights offers flight deals from Milwaukee to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Milwaukee to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $217). Flying from Milwaukee to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Milwaukee to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
O'Hare Intl to Las Vegas flights
O'Hare Intl to John F Kennedy Intl flights
O'Hare Intl to LaGuardia flights
O'Hare Intl to Newark flights
O'Hare Intl to Dallas/Fort Worth flights
O'Hare Intl to Seattle flights
Minneapolis to Las Vegas flights
O'Hare Intl to Sky Harbor Intl flights
O'Hare Intl to Orlando flights
Minneapolis to Dallas/Fort Worth flights
O'Hare Intl to Los Angeles flights
O'Hare Intl to Boston flights
Minneapolis to Orlando flights
O'Hare Intl to San Francisco flights
Minneapolis to John F Kennedy Intl flights
Minneapolis to Seattle flights
O'Hare Intl to Denver flights
Minneapolis to LaGuardia flights
O'Hare Intl to Miami flights
O'Hare Intl to Fort Lauderdale flights
Minneapolis to Newark flights
Minneapolis to Denver flights
O'Hare Intl to Dulles Intl flights
Minneapolis to Sky Harbor Intl flights
O'Hare Intl to Atlanta flights
O'Hare Intl to San Diego flights
O'Hare Intl to Reagan-National flights
Minneapolis to Portland flights
O'Hare Intl to Honolulu flights
O'Hare Intl to Tampa flights
O'Hare Intl to Philadelphia flights
Minneapolis to Miami flights
O'Hare Intl to Santa Ana flights
O'Hare Intl to Ontario flights
O'Hare Intl to Austin flights
Minneapolis to Los Angeles flights
O'Hare Intl to Nashville flights
O'Hare Intl to Portland flights
O'Hare Intl to Baltimore flights
Milwaukee to LaGuardia flights
Minneapolis to O'Hare Intl flights
Minneapolis to San Francisco flights
Minneapolis to Dulles Intl flights
Milwaukee to Las Vegas flights
Minneapolis to Fort Lauderdale flights
O'Hare Intl to Hobby flights
Minneapolis to Charleston flights
Minneapolis to Reagan-National flights
Minneapolis to San Diego flights
Milwaukee to Seattle flights

Top 5 airlines flying from Milwaukee to South Carolina

Discover the top 5 airlines that operate flights from Milwaukee to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$141Average$241FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$228Average$379FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$379FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$256Average$401FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$256Average$389FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.