$86+ Cheap flights from Milwaukee (MKE) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel.
MKE — CHS
Mar 13 — Mar 201
1 adult, Economy
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Find cheap flights from Milwaukee to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Milwaukee to South Carolina
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Cheapest flights from Milwaukee to South CarolinaExplore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.
Explore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.
This Expedia deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:37 pm
MKE
- CLT
1 stop11h 12m
Frontier
Mon 2/2310:42 pm
CLT
- MKE
1 stop18h 02m
Frontier
Deal found 2/9![Frontier logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:11 pm
MKE
- CLT
1 stop16h 40m
Frontier
Wed 3/42:46 pm
CLT
- MKE
1 stop28h 56m
Frontier
Deal found 2/9![Frontier logo]()
$185
This Frontier deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/238:20 pm
MKE
- CLT
1 stop10h 43m
Frontier
Wed 3/259:08 am
CLT
- MKE
1 stop9h 42m
Frontier
Deal found 2/10![Frontier logo]()
$189
This Expedia deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/176:35 pm
MKE
- CLT
1 stop17h 20m
Frontier
Mon 3/232:32 pm
CLT
- MKE
1 stop6h 03m
Frontier
Deal found 2/8![Frontier logo]()
$210
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:48 pm
MKE
- CLT
Nonstop2h 12m
American Airlines
Wed 2/2510:48 pm
CLT
- MKE
1 stop10h 01m
American Airlines
Deal found 2/9![American Airlines logo]()
$232
This Frontier deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:37 pm
MKE
- CLT
1 stop11h 21m
Frontier
Mon 3/27:44 am
CLT
- MKE
1 stop12h 42m
Frontier
Deal found 2/11![Frontier logo]()
$250
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:00 am
MKE
- CLT
Nonstop2h 13m
American Airlines
Sat 2/1411:20 am
CLT
- MKE
1 stop8h 41m
American Airlines
Deal found 2/8![American Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:35 pm
MKE
- CLT
1 stop17h 20m
Multiple Airlines
Thu 3/123:55 pm
CLT
- MKE
1 stop20h 41m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$256
This Expedia deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/167:52 pm
MKE
- CLT
1 stop11h 21m
Frontier
Sat 2/219:28 am
CLT
- MKE
1 stop10h 24m
Frontier
Deal found 2/10![Frontier logo]()
$261
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:00 am
MKE
- CAE
1 stop4h 01m
United Airlines
Wed 3/186:15 am
CAE
- MKE
1 stop5h 15m
United Airlines
Deal found 2/11![United Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:39 am
MKE
- HHH
1 stop4h 58m
American Airlines
Wed 4/225:04 pm
HHH
- MKE
1 stop6h 53m
American Airlines
Deal found 2/9![American Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2612:55 pm
MKE
- CLT
1 stop6h 20m
Southwest
Sat 2/287:45 am
CLT
- MKE
1 stop7h 05m
Southwest
Deal found 2/8![Southwest logo]()
$270
Best flights from Milwaukee to South CarolinaDiscover carefully curated flight deals from Milwaukee to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 11, 2026.
Discover carefully curated flight deals from Milwaukee to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 11, 2026.
This Frontier deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/238:20 pm
MKE
- CLT
1 stop10h 43m
Frontier
Wed 3/259:08 am
CLT
- MKE
1 stop9h 42m
Frontier
Deal found 2/11![Frontier logo]()
$244
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:39 am
MKE
- HHH
1 stop4h 58m
American Airlines
Wed 4/225:04 pm
HHH
- MKE
1 stop6h 53m
American Airlines
Deal found 2/9![American Airlines logo]()
$269
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:10 am
MKE
- HHH
2 stops9h 20m
United Airlines
Wed 4/223:00 pm
HHH
- MKE
1 stop7h 49m
United Airlines
Deal found 2/9![United Airlines logo]()
$274
This Southwest deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2612:55 pm
MKE
- CLT
1 stop6h 20m
Southwest
Sat 2/281:10 pm
CLT
- MKE
2 stops10h 15m
Southwest
Deal found 2/8![Southwest logo]()
$276
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/31:35 pm
MKE
- GSP
1 stop5h 44m
Delta
Wed 3/187:30 am
GSP
- MKE
1 stop6h 00m
Delta
Deal found 2/10![Delta logo]()
$307
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:00 am
MKE
- HHH
1 stop6h 24m
American Airlines
Sat 5/95:04 pm
HHH
- MKE
1 stop6h 43m
American Airlines
Deal found 2/10![American Airlines logo]()
$276
This Southwest deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2012:55 pm
MKE
- CLT
1 stop6h 20m
Southwest
Mon 2/235:05 pm
CLT
- MKE
1 stop6h 05m
Southwest
Deal found 2/9![Southwest logo]()
$277
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:00 am
MKE
- CAE
2 stops8h 04m
United Airlines
Sat 2/283:32 pm
CAE
- MKE
1 stop7h 12m
United Airlines
Deal found 2/11![United Airlines logo]()
$284
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1112:10 pm
MKE
- CAE
1 stop5h 38m
American Airlines
Wed 3/185:00 am
CAE
- MKE
2 stops7h 40m
American Airlines
Deal found 2/11![American Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/31:35 pm
MKE
- GSP
1 stop4h 02m
Delta
Tue 3/177:30 am
GSP
- MKE
1 stop6h 00m
Delta
Deal found 2/10![Delta logo]()
$307
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/185:30 am
MKE
- CLT
2 stops9h 50m
Southwest
Wed 2/258:25 am
CLT
- MKE
1 stop4h 05m
Southwest
Deal found 2/10![Southwest logo]()
$282
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/2412:10 pm
MKE
- CAE
1 stop5h 46m
American Airlines
Sat 2/288:11 pm
CAE
- MKE
1 stop4h 44m
American Airlines
Deal found 2/9![American Airlines logo]()
$279
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/117:00 am
MKE
- GSP
2 stops6h 17m
United Airlines
Wed 3/186:15 am
GSP
- MKE
2 stops8h 24m
United Airlines
Deal found 2/11![United Airlines logo]()
$307
This Delta deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/912:11 pm
MKE
- GSP
1 stop5h 43m
Delta
Wed 3/118:30 am
GSP
- MKE
1 stop4h 43m
Delta
Deal found 2/8![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/304:50 pm
MKE
- CLT
1 stop4h 00m
Southwest
Sun 5/37:50 pm
CLT
- MKE
1 stop4h 55m
Southwest
Deal found 2/9![Southwest logo]()
$282
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/248:00 am
MKE
- HHH
1 stop6h 01m
American Airlines
Sat 2/284:31 pm
HHH
- MKE
1 stop7h 53m
American Airlines
Deal found 2/9![American Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:45 am
MKE
- GSP
1 stop4h 20m
Delta
Mon 3/167:59 pm
GSP
- MKE
1 stop4h 59m
Delta
Deal found 2/9![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:49 am
MKE
- MYR
1 stop6h 29m
United Airlines
Sat 5/93:14 pm
MYR
- MKE
1 stop6h 34m
United Airlines
Deal found 2/9![United Airlines logo]()
$317
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/117:05 am
MKE
- GSP
1 stop3h 55m
Southwest
Wed 3/186:25 pm
GSP
- MKE
1 stop5h 40m
Southwest
Deal found 2/11![Southwest logo]()
$297
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:33 pm
MKE
- MYR
1 stop5h 41m
Delta
Sat 5/26:00 am
MYR
- MKE
1 stop4h 05m
Delta
Deal found 2/9![Delta logo]()
$317
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:50 am
MKE
- MYR
1 stop6h 27m
United Airlines
Tue 4/283:15 pm
MYR
- MKE
1 stop4h 32m
United Airlines
Deal found 2/10![United Airlines logo]()
$317
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/242:40 pm
MKE
- CLT
1 stop6h 20m
Southwest
Wed 3/257:45 am
CLT
- MKE
1 stop5h 00m
Southwest
Deal found 2/11![Southwest logo]()
$300
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/96:37 pm
MKE
- GSP
1 stop4h 17m
American Airlines
Wed 3/117:07 am
GSP
- MKE
1 stop5h 33m
American Airlines
Deal found 2/11![American Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:45 pm
MKE
- MYR
1 stop4h 19m
Delta
Tue 4/1410:26 am
MYR
- MKE
1 stop6h 58m
Delta
Deal found 2/11![Delta logo]()
$317
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:50 am
MKE
- SAV
1 stop5h 50m
United Airlines
Sat 4/259:15 am
SAV
- MKE
1 stop5h 32m
United Airlines
Deal found 2/10![United Airlines logo]()
$317
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/204:55 pm
MKE
- CLT
1 stop4h 30m
Southwest
Sat 3/216:05 am
CLT
- MKE
1 stop6h 15m
Southwest
Deal found 2/10![Southwest logo]()
$303
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:39 am
MKE
- GSP
1 stop5h 35m
American Airlines
Mon 5/117:48 pm
GSP
- MKE
1 stop4h 43m
American Airlines
Deal found 2/9![American Airlines logo]()
$316
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:33 pm
MKE
- SAV
1 stop5h 26m
Delta
Sat 5/26:50 am
SAV
- MKE
1 stop5h 37m
Delta
Deal found 2/10![Delta logo]()
$317
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/252:32 pm
MKE
- CHS
1 stop5h 53m
United Airlines
Tue 4/286:00 am
CHS
- MKE
2 stops6h 32m
United Airlines
Deal found 2/9![United Airlines logo]()
$322
This Southwest deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/195:25 am
MKE
- CLT
1 stop11h 15m
Southwest
Fri 2/208:50 pm
CLT
- MKE
1 stop4h 00m
Southwest
Deal found 2/9![Southwest logo]()
$308
Last-minute flights from Milwaukee to South CarolinaDiscover last-minute flight deals from Milwaukee to South Carolina. Data last updated February 11, 2026 and is based on user searches.
Discover last-minute flight deals from Milwaukee to South Carolina. Data last updated February 11, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:00 am
MKE
- CLT
Nonstop2h 13m
American Airlines
Sat 2/1411:20 am
CLT
- MKE
1 stop8h 41m
American Airlines
Deal found 2/8![American Airlines logo]()
$255
This Expedia deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/167:52 pm
MKE
- CLT
1 stop11h 21m
Frontier
Sat 2/219:28 am
CLT
- MKE
1 stop10h 24m
Frontier
Deal found 2/10![Frontier logo]()
$261
This Expedia deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:37 pm
MKE
- CLT
1 stop11h 12m
Frontier
Mon 2/2310:42 pm
CLT
- MKE
1 stop18h 02m
Frontier
Deal found 2/9![Frontier logo]()
$181
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/2412:10 pm
MKE
- CAE
1 stop5h 46m
American Airlines
Sat 2/288:11 pm
CAE
- MKE
1 stop4h 44m
American Airlines
Deal found 2/9![American Airlines logo]()
$279
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:48 pm
MKE
- CLT
Nonstop2h 12m
American Airlines
Wed 2/2510:48 pm
CLT
- MKE
1 stop10h 01m
American Airlines
Deal found 2/9![American Airlines logo]()
$232
This Frontier deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:37 pm
MKE
- CLT
1 stop11h 21m
Frontier
Mon 3/27:44 am
CLT
- MKE
1 stop12h 42m
Frontier
Deal found 2/11![Frontier logo]()
$250
This Southwest deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2612:55 pm
MKE
- CLT
1 stop6h 20m
Southwest
Sat 2/287:45 am
CLT
- MKE
1 stop7h 05m
Southwest
Deal found 2/8![Southwest logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:11 pm
MKE
- CLT
1 stop16h 40m
Frontier
Wed 3/42:46 pm
CLT
- MKE
1 stop28h 56m
Frontier
Deal found 2/9![Frontier logo]()
$185
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:35 pm
MKE
- CLT
1 stop17h 20m
Multiple Airlines
Thu 3/123:55 pm
CLT
- MKE
1 stop20h 41m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$256
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:00 am
MKE
- CAE
1 stop4h 01m
United Airlines
Wed 3/186:15 am
CAE
- MKE
1 stop5h 15m
United Airlines
Deal found 2/11![United Airlines logo]()
$269
This Expedia deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/176:35 pm
MKE
- CLT
1 stop17h 20m
Frontier
Mon 3/232:32 pm
CLT
- MKE
1 stop6h 03m
Frontier
Deal found 2/8![Frontier logo]()
$210
This Priceline deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/238:20 pm
MKE
- CLT
1 stop10h 43m
Frontier
Wed 3/259:08 am
CLT
- MKE
1 stop9h 42m
Frontier
Deal found 2/9![Frontier logo]()
$189
One-way flights from Milwaukee to South CarolinaSearch for one-way flight options from Milwaukee to South Carolina. Find affordable one-way fares based on user searches. Data last updated February 11, 2026.
Search for one-way flight options from Milwaukee to South Carolina. Find affordable one-way fares based on user searches. Data last updated February 11, 2026.
This Frontier deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:35 pm
MKE
- CLT
1 stop12h 28m
Frontier
Deal found 2/10![Frontier logo]()
$86
This Trip.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:11 pm
MKE
- CLT
1 stop13h 06m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$88
This Trip.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1012:03 pm
MKE
- CLT
1 stop27h 32m
Frontier
Deal found 2/11![Frontier logo]()
$89
This Southwest deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/24:55 pm
MKE
- CLT
1 stop4h 30m
Southwest
Deal found 2/9![Southwest logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/89:01 pm
MKE
- CLT
1 stop12h 16m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$103
This Frontier deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:42 pm
MKE
- CLT
1 stop12h 36m
Frontier
Deal found 2/11![Frontier logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/89:01 pm
MKE
- CLT
1 stop9h 57m
Frontier
Deal found 2/8![Frontier logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/912:36 pm
MKE
- CLT
1 stop18h 27m
Frontier
Deal found 2/8![Frontier logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:35 pm
MKE
- CLT
1 stop12h 28m
Frontier
Deal found 2/8![Frontier logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/89:01 pm
MKE
- CHS
1 stop10h 42m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$135
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/241:25 pm
MKE
- GSP
1 stop6h 26m
United Airlines
Deal found 2/10![United Airlines logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/89:01 pm
MKE
- GSP
1 stop21h 37m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$150
Find flight deals from Milwaukee to South Carolina
Keep the following information in mind while searching for Milwaukee to South Carolina flight deals. Data was last updated February 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $181 (Expedia) |
One-way from | $86 (Frontier) |
Popular in | March |
Cheapest in | January |
Average price | $366 |
Cheapflights Fare Finder
Customize your flight search to find flights from Milwaukee to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Milwaukee to South Carolina that are best for you.
Fly from
Milwaukee
Fly to
South Carolina
Route
Depart
Return
Price
MilwaukeeCharlotte
MKE - CLT
MKECLT
Milwaukee-Mitchell
Mon 3/23
8:20 pm-8:03 am
1 stop10h 43m
Charlotte Douglas
Wed 3/25
9:08 am-5:50 pm
1 stop9h 42m
$244
MilwaukeeHilton Head Island
MKE - HHH
MKEHHH
Milwaukee-Mitchell
Tue 4/14
6:39 am-12:37 pm
1 stop4h 58m
Hilton Head Island
Wed 4/22
5:04 pm-10:57 pm
1 stop6h 53m
$269
MilwaukeeHilton Head Island
MKE - HHH
MKEHHH
Milwaukee-Mitchell
Tue 4/14
5:10 am-3:30 pm
2 stops9h 20m
Hilton Head Island
Wed 4/22
3:00 pm-9:49 pm
1 stop7h 49m
$274
MilwaukeeCharlotte
MKE - CLT
MKECLT
Milwaukee-Mitchell
Thu 2/26
12:55 pm-8:15 pm
1 stop6h 20m
Charlotte Douglas
Sat 2/28
1:10 pm-10:25 pm
2 stops10h 15m
$276
MilwaukeeHilton Head Island
MKE - HHH
MKEHHH
Milwaukee-Mitchell
Sat 5/2
7:00 am-2:24 pm
1 stop6h 24m
Hilton Head Island
Sat 5/9
5:04 pm-10:47 pm
1 stop6h 43m
$276
MilwaukeeCharlotte
MKE - CLT
MKECLT
Milwaukee-Mitchell
Fri 2/20
12:55 pm-8:15 pm
1 stop6h 20m
Charlotte Douglas
Mon 2/23
5:05 pm-10:10 pm
1 stop6h 05m
$277
MilwaukeeColumbia
MKE - CAE
MKECAE
Milwaukee-Mitchell
Wed 3/11
12:10 pm-6:48 pm
1 stop5h 38m
Columbia Metropolitan
Wed 3/18
5:00 am-11:40 am
2 stops7h 40m
$279
MilwaukeeColumbia
MKE - CAE
MKECAE
Milwaukee-Mitchell
Tue 2/24
12:10 pm-6:56 pm
1 stop5h 46m
Columbia Metropolitan
Sat 2/28
8:11 pm-11:55 pm
1 stop4h 44m
$279
MilwaukeeHilton Head Island
MKE - HHH
MKEHHH
Milwaukee-Mitchell
Tue 2/24
8:00 am-3:01 pm
1 stop6h 01m
Hilton Head Island
Sat 2/28
4:31 pm-11:24 pm
1 stop7h 53m
$279
MilwaukeeCharlotte
MKE - CLT
MKECLT
Milwaukee-Mitchell
Wed 2/18
5:30 am-4:20 pm
2 stops9h 50m
Charlotte Douglas
Wed 2/25
8:25 am-11:30 am
1 stop4h 05m
$282
Showing 1-10 of 60 results
Best time to book a flight from Milwaukee to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Milwaukee with our price prediction graph.
MKE-CLT
MKE-CHS
MKE-GSP
MKE-CAE
MKE-HHH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Milwaukee to South Carolina
MKE-USSC
MKE-CLT
MKE-CHS
MKE-GSP
MKE-CAE
What is the cheapest month to book a flight from Milwaukee to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $60). Flying from Milwaukee to South Carolina in February is currently the most expensive (average of $207). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MKE to SC?
Find hourly flight availability from Milwaukee to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 11, 2026.
It’s typically best to fly out from Milwaukee to South Carolina in the evening. Doing so could potentially save you 37% on the flight price compared to flying in the afternoon, which is usually more expensive.
What is the cheapest day to fly from Milwaukee to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Milwaukee to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Milwaukee to South Carolina flight should consider departing on Friday evenings when fares are most often at their lowest. Saturday evenings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 11, 2026.
See what other customers who have flown with Southwest, Delta, and United Airlines from Milwaukee to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Overall
8.0
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Overall
8.0
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Overall
8.0
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Overall
8.0
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Overall
8.0
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Milwaukee to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Milwaukee to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Milwaukee to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Milwaukee and South Carolina flights
Browse other Milwaukee and South Carolina flight options. Last updated on February 11, 2026.
Popular flight searches
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Milwaukee to South Carolina flights
Consider these flights traveling from Milwaukee to South Carolina.
Top 5 airlines flying from Milwaukee to South Carolina
Discover the top 5 airlines that operate flights from Milwaukee to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$127 | Average$358 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$189 | Average$198 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$201 | Average$396 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$213 | Average$394 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$223 | Average$379 | FlexibilityNo cancel fee | On-time71% |