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South Carolina

$61+ Cheap flights from Milwaukee (MKE) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/8. Fares are subject to change and may not be available on all flights or dates of travel.
MKE — CHS
dic. 13 — dic. 201
sáb. 12/13
sáb. 12/20
1 adult, Economy
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Cheap flight deals from Milwaukee to South Carolina

Keep the following information in mind while searching for Milwaukee to South Carolina flight deals. Data was last updated noviembre 13, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$197
(Frontier)

One-way from

$61
(Frontier)

Popular in

March

Cheapest in

November

Average price

$300
Provider with most accurate pricing for Milwaukee-Mitchell-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Milwaukee-Mitchell-Myrtle Beach Intl flights.
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From Milwaukee-Mitchell to South Carolina
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One-way flight from Milwaukee-Mitchell to South Carolina
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Highest demand for flights based on searches. 7% potential increase in price ($30 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Milwaukee to South Carolina

Cheapest flights from Milwaukee to South Carolina
Explore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on noviembre 13, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/1110:34 amMKE - CLT
1 stop10h 04mMultiple Airlines
jue. 12/187:19 pmCLT - MKE
1 stop24h 07mMultiple Airlines
Deal found 11/13$224
This Mytrip deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/810:34 amMKE - CLT
1 stop8h 26mSpirit Airlines
jue. 12/118:55 pmCLT - MKE
1 stop13h 44mSpirit Airlines
Deal found 11/12$241
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/810:34 amMKE - CLT
1 stop8h 26mMultiple Airlines
mié. 12/1010:45 amCLT - MKE
1 stop23h 54mMultiple Airlines
Deal found 11/11$247
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/1011:41 amMKE - CAE
1 stop6h 16mDelta
mié. 12/1711:00 amCAE - MKE
1 stop4h 21mDelta
Deal found 11/12$249
This Kiwi.com deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/810:34 amMKE - CLT
1 stop8h 26mMultiple Airlines
jue. 12/1110:33 pmCLT - MKE
1 stop19h 36mMultiple Airlines
Deal found 11/13$251
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/710:34 amMKE - CLT
1 stop10h 04mMultiple Airlines
mar. 12/98:10 pmCLT - MKE
2 stops38h 29mMultiple Airlines
Deal found 11/10$253
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/188:15 pmMKE - CLT
2 stops13h 28mMultiple Airlines
sáb. 12/209:02 pmCLT - MKE
1 stop23h 19mMultiple Airlines
Deal found 11/12$254
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/912:34 pmMKE - CAE
2 stops8h 04mAmerican Airlines
mar. 12/166:49 amCAE - MKE
1 stop6h 15mAmerican Airlines
Deal found 11/11$254
This Frontier deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/56:09 pmMKE - CLT
1 stop12h 48mFrontier
dom. 12/78:52 amCLT - MKE
1 stop9h 17mFrontier
Deal found 11/11$255
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/318:15 pmMKE - CLT
1 stop21h 09mMultiple Airlines
dom. 1/49:34 pmCLT - MKE
2 stops13h 19mMultiple Airlines
Deal found 11/11$259
This Mytrip deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/1110:34 amMKE - CLT
1 stop8h 26mSpirit Airlines
dom. 12/148:55 pmCLT - MKE
1 stop13h 44mSpirit Airlines
Deal found 11/12$262
This Kiwi.com deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/1510:34 amMKE - MYR
2 stops20h 26mMultiple Airlines
jue. 12/187:32 pmMYR - MKE
1 stop23h 54mMultiple Airlines
Deal found 11/13$262

Cheapflights Fare Finder

 
Customize your flight search to find flights from Milwaukee to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 13, 2025.
Use the filters below to find and compare flights from Milwaukee to South Carolina that are best for you.

Fly from

Milwaukee

Fly to

South Carolina

Route

Depart

Return

Price

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

sáb. 3/7

6:29 pm-11:48 pm

1 stop4h 19m

Columbia Metropolitan

mié. 3/11

5:40 am-9:27 am

1 stop4h 47m

$249

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

mié. 12/10

12:34 pm-6:42 pm

1 stop5h 08m

Columbia Metropolitan

mié. 12/17

6:49 am-12:04 pm

1 stop6h 15m

$249

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

jue. 2/12

12:20 pm-8:29 pm

1 stop7h 09m

Columbia Metropolitan

dom. 2/15

6:40 am-10:12 am

1 stop4h 32m

$249

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

mar. 12/9

5:11 pm-11:31 pm

1 stop5h 20m

Columbia Metropolitan

mar. 12/16

5:34 am-10:45 am

1 stop6h 11m

$249

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

dom. 12/7

10:34 am-9:38 pm

1 stop10h 04m

Charlotte Douglas

mar. 12/9

8:10 pm-9:39 am

2 stops38h 29m

$253

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

mar. 12/9

12:34 pm-9:38 pm

2 stops8h 04m

Columbia Metropolitan

mar. 12/16

6:49 am-12:04 pm

1 stop6h 15m

$254

MilwaukeeMyrtle Beach

MKE - MYR

MKEMYR

Milwaukee-Mitchell

lun. 12/15

10:34 am-8:00 am

2 stops20h 26m

Myrtle Beach Intl

jue. 12/18

7:32 pm-6:26 pm

1 stop23h 54m

$262

MilwaukeeMyrtle Beach

MKE - MYR

MKEMYR

Milwaukee-Mitchell

mié. 2/4

6:56 pm-12:12 pm

1 stop16h 16m

Myrtle Beach Intl

dom. 2/8

1:07 pm-9:58 am

2 stops21h 51m

$263

MilwaukeeSavannah

MKE - SAV

MKESAV

Milwaukee-Mitchell

jue. 12/11

10:34 am-11:18 pm

2 stops11h 44m

Savannah/Hilton Head

jue. 12/18

7:00 am-7:20 pm

2 stops13h 20m

$267

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

sáb. 11/29

7:00 pm-3:04 am

1 stop7h 04m

Columbia Metropolitan

mié. 12/3

10:20 am-3:08 pm

1 stop5h 48m

$291

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/12

Showing 1-10 of 60 results
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Best time to book a flight from Milwaukee to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Milwaukee with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Milwaukee to South Carolina

What is the cheapest month to book a flight from Milwaukee to South Carolina?

Currently, July is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $60). Flying from Milwaukee to South Carolina in December is currently the most expensive (average of $202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MKE to SC?

Find hourly flight availability from Milwaukee to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated noviembre 13, 2025.

It’s typically best to fly out from Milwaukee to South Carolina in the evening. Doing so could potentially save you 32% on the flight price compared to flying at noon, which is usually more expensive.

What is the cheapest day to fly from Milwaukee to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Milwaukee to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Milwaukee to South Carolina flight should consider departing on Friday evenings when fares are most often at their lowest. Saturday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated noviembre 13, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Milwaukee to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
8,007 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
9,017 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,051 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Spirit Airlines
6.3
Okay
8,139 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Milwaukee to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Milwaukee to South Carolina?

    Milwaukee-Mitchell (MKE), located 6.4 mi from the city center, is the airport you fly out of when you book flights from Milwaukee to South Carolina.

  • How long is the flight from Milwaukee to South Carolina?

    Delta, American Airlines, and United Airlines can get you from Milwaukee to South Carolina in just under 4h 19m. Your travel time can differ by up to 3h 58m. There are 721 mi between Milwaukee and South Carolina. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Milwaukee to South Carolina one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $61. Users have also found prices from $129 and $149 on Spirit Airlines and Delta, respectively.

  • What are the most popular routes from Milwaukee to South Carolina?

    While some choose either Milwaukee-Mitchell - Charleston or Milwaukee-Mitchell - Myrtle Beach Intl, Milwaukee-Mitchell - Charlotte Douglas is the most popular route from Milwaukee to South Carolina.

  • Can I find deals for flights from Milwaukee to South Carolina that include hotel bookings?

    Yes. In addition to deals on Milwaukee to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Milwaukee to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Milwaukee to South Carolina.

  • Can I find deals for business class flights from Milwaukee to South Carolina?

    Yes. Cheapflights offers flight deals from Milwaukee to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Milwaukee to South Carolina?

    Currently, July is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $60). Flying from Milwaukee to South Carolina in December is currently the most expensive (average of $202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Milwaukee to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Milwaukee to South Carolina

Discover the top 5 airlines that operate flights from Milwaukee to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$141Average$239FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$228Average$374FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$360FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$409FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$256Average$400FlexibilityNo cancel feeOn-time63%

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