$70+ Cheap flights from Milwaukee (MKE) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/5. Fares are subject to change and may not be available on all flights or dates of travel.
MKE — CHS
maj 11 — maj 181
Round-trip
1 adult, Economy
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Cheapest flights from Milwaukee to South CarolinaExplore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on april 11, 2026.
Explore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on april 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tis 5/59:56 am
MKE
- CLT
1 stop8h 17m
Frontier
ons 5/67:58 pm
CLT
- MKE
1 stop14h 03m
Frontier
Deal found 4/10![Frontier logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tors 5/149:46 am
MKE
- CLT
1 stop8h 06m
Multiple Airlines
mån 5/187:58 pm
CLT
- MKE
1 stop14h 03m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$200
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tors 4/3012:21 pm
MKE
- CLT
1 stop7h 16m
Multiple Airlines
mån 5/48:09 pm
CLT
- MKE
1 stop13h 52m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$220
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sön 4/199:33 am
MKE
- CLT
1 stop21h 36m
Multiple Airlines
ons 4/298:09 pm
CLT
- MKE
1 stop16h 17m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tis 5/59:56 am
MKE
- CLT
1 stop7h 56m
Multiple Airlines
ons 5/67:58 pm
CLT
- MKE
1 stop14h 03m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fre 4/177:34 pm
MKE
- CLT
1 stop20h 01m
Frontier
lör 4/188:09 pm
CLT
- MKE
1 stop13h 29m
Frontier
Deal found 4/10![Frontier logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sön 4/199:33 am
MKE
- CLT
1 stop21h 36m
Multiple Airlines
ons 4/229:32 pm
CLT
- MKE
1 stop14h 54m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fre 4/177:34 pm
MKE
- CLT
1 stop20h 01m
Frontier
sön 4/197:19 pm
CLT
- MKE
1 stop17h 07m
Frontier
Deal found 4/9![Frontier logo]()
$237
This Trip.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tors 4/1612:21 pm
MKE
- CLT
1 stop21h 59m
Frontier
sön 4/1910:31 pm
CLT
- MKE
1 stop16h 21m
Frontier
Deal found 4/8![Frontier logo]()
$239
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ons 10/287:24 am
MKE
- CAE
1 stop5h 41m
American Airlines
lör 10/3112:45 pm
CAE
- MKE
1 stop7h 05m
American Airlines
Deal found 4/7![American Airlines logo]()
$261
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lör 5/96:00 am
MKE
- HHH
1 stop6h 40m
American Airlines
lör 5/166:50 pm
HHH
- MKE
1 stop4h 57m
American Airlines
Deal found 4/8![American Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mån 5/412:21 pm
MKE
- CHS
1 stop20h 12m
Multiple Airlines
ons 5/64:34 pm
CHS
- MKE
1 stop17h 27m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$263
Best flights from Milwaukee to South CarolinaDiscover carefully curated flight deals from Milwaukee to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated april 11, 2026.
Discover carefully curated flight deals from Milwaukee to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated april 11, 2026.
This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tis 5/126:00 am
MKE
- CAE
1 stop7h 28m
American Airlines
lör 5/164:15 pm
CAE
- MKE
1 stop7h 12m
American Airlines
Deal found 4/9![American Airlines logo]()
$261
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tis 7/2810:11 am
MKE
- HHH
1 stop4h 18m
Delta
tis 8/412:11 pm
HHH
- MKE
1 stop5h 20m
Delta
Deal found 4/10![Delta logo]()
$261
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fre 5/13:30 pm
MKE
- MYR
1 stop4h 20m
Southwest
mån 5/43:45 pm
MYR
- MKE
1 stop8h 40m
Southwest
Deal found 4/8![Southwest logo]()
$296
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ons 4/228:30 am
MKE
- HHH
1 stop4h 46m
United Airlines
tis 4/283:05 pm
HHH
- MKE
1 stop7h 44m
United Airlines
Deal found 4/9![United Airlines logo]()
$347
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mån 5/1110:13 am
MKE
- HHH
1 stop4h 20m
Delta
tis 5/1912:18 pm
HHH
- MKE
1 stop4h 54m
Delta
Deal found 4/9![Delta logo]()
$276
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ons 7/1510:11 am
MKE
- HHH
1 stop4h 18m
Delta
tis 7/214:12 pm
HHH
- MKE
1 stop7h 18m
Delta
Deal found 4/7![Delta logo]()
$281
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lör 5/96:30 am
MKE
- MYR
2 stops8h 40m
Southwest
fre 5/153:45 pm
MYR
- MKE
2 stops8h 05m
Southwest
Deal found 4/10![Southwest logo]()
$311
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fre 5/17:00 am
MKE
- HHH
1 stop6h 26m
American Airlines
tis 5/52:54 pm
HHH
- MKE
2 stops9h 31m
American Airlines
Deal found 4/7![American Airlines logo]()
$334
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lör 5/22:00 pm
MKE
- CHS
1 stop3h 35m
Southwest
tis 5/57:15 pm
CHS
- MKE
1 stop4h 20m
Southwest
Deal found 4/8![Southwest logo]()
$311
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ons 5/135:23 am
MKE
- CAE
1 stop4h 48m
Delta
mån 5/183:53 pm
CAE
- MKE
1 stop6h 09m
Delta
Deal found 4/8![Delta logo]()
$286
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tors 5/217:00 am
MKE
- CAE
1 stop6h 05m
American Airlines
sön 5/246:39 pm
CAE
- MKE
1 stop6h 08m
American Airlines
Deal found 4/6![American Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fre 5/154:50 pm
MKE
- CHS
1 stop4h 05m
Southwest
ons 5/203:40 pm
CHS
- MKE
1 stop7h 35m
Southwest
Deal found 4/6![Southwest logo]()
$311
This United Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fre 4/242:32 pm
MKE
- CAE
1 stop5h 49m
United Airlines
ons 5/272:29 pm
CAE
- MKE
1 stop6h 22m
United Airlines
Deal found 4/11![United Airlines logo]()
$378
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lör 5/165:23 am
MKE
- CAE
1 stop4h 48m
Delta
sön 5/175:38 am
CAE
- MKE
1 stop4h 30m
Delta
Deal found 4/8![Delta logo]()
$286
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ons 4/227:00 am
MKE
- HHH
1 stop6h 26m
American Airlines
lör 4/256:50 pm
HHH
- MKE
1 stop5h 07m
American Airlines
Deal found 4/6![American Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sön 5/175:10 pm
MKE
- CHS
1 stop4h 00m
Southwest
ons 5/206:20 pm
CHS
- MKE
1 stop4h 35m
Southwest
Deal found 4/7![Southwest logo]()
$311
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tis 5/55:55 am
MKE
- GSP
2 stops7h 22m
United Airlines
fre 5/85:45 pm
GSP
- MKE
1 stop5h 18m
United Airlines
Deal found 4/10![United Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mån 6/14:18 pm
MKE
- MYR
1 stop6h 40m
Delta
tis 6/91:51 pm
MYR
- MKE
1 stop6h 26m
Delta
Deal found 4/6![Delta logo]()
$291
This American Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lör 4/258:11 am
MKE
- HHH
2 stops7h 23m
American Airlines
fre 5/12:58 pm
HHH
- MKE
2 stops8h 02m
American Airlines
Deal found 4/10![American Airlines logo]()
$344
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fre 5/83:25 pm
MKE
- CHS
2 stops7h 34m
United Airlines
sön 5/106:00 am
CHS
- MKE
1 stop4h 45m
United Airlines
Deal found 4/10![United Airlines logo]()
$382
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sön 5/246:10 pm
MKE
- MYR
1 stop4h 48m
Delta
fre 5/2911:43 am
MYR
- MKE
1 stop4h 29m
Delta
Deal found 4/10![Delta logo]()
$291
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tis 5/511:30 am
MKE
- GSP
1 stop3h 50m
Southwest
tis 5/125:05 pm
GSP
- MKE
2 stops5h 40m
Southwest
Deal found 4/7![Southwest logo]()
$324
This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ons 5/277:11 am
MKE
- AGS
1 stop7h 19m
American Airlines
ons 6/36:00 am
AGS
- MKE
1 stop7h 19m
American Airlines
Deal found 4/9![American Airlines logo]()
$345
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tis 5/199:37 am
MKE
- CHS
1 stop7h 25m
United Airlines
ons 5/201:19 pm
CHS
- MKE
1 stop6h 38m
United Airlines
Deal found 4/10![United Airlines logo]()
$391
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tors 7/210:08 am
MKE
- CAE
1 stop4h 01m
Delta
tors 7/95:35 am
CAE
- MKE
1 stop4h 31m
Delta
Deal found 4/9![Delta logo]()
$301
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mån 5/46:50 am
MKE
- GSP
1 stop4h 10m
Southwest
mån 5/116:25 pm
GSP
- MKE
1 stop6h 00m
Southwest
Deal found 4/6![Southwest logo]()
$347
This American Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tis 5/196:40 pm
MKE
- SAV
1 stop4h 37m
American Airlines
tis 5/266:36 pm
SAV
- MKE
1 stop5h 34m
American Airlines
Deal found 4/10![American Airlines logo]()
$351
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sön 4/267:50 am
MKE
- CAE
1 stop5h 59m
United Airlines
tors 4/306:30 am
CAE
- MKE
1 stop4h 15m
United Airlines
Deal found 4/10![United Airlines logo]()
$397
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tors 7/96:45 pm
MKE
- CAE
1 stop4h 04m
Delta
lör 8/85:55 pm
CAE
- MKE
1 stop4h 14m
Delta
Deal found 4/6![Delta logo]()
$306
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ons 6/1010:15 am
MKE
- SAV
1 stop6h 30m
Southwest
tis 6/236:35 pm
SAV
- MKE
1 stop4h 25m
Southwest
Deal found 4/10![Southwest logo]()
$351
Last-minute flights from Milwaukee to South CarolinaDiscover last-minute flight deals from Milwaukee to South Carolina. Data last updated april 11, 2026 and is based on user searches.
Discover last-minute flight deals from Milwaukee to South Carolina. Data last updated april 11, 2026 and is based on user searches.
This Trip.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fre 4/177:34 pm
MKE
- CLT
1 stop20h 01m
Frontier
sön 4/1910:31 pm
CLT
- MKE
1 stop16h 21m
Frontier
Deal found 4/6![Frontier logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fre 4/177:34 pm
MKE
- CLT
1 stop20h 01m
Frontier
lör 4/188:09 pm
CLT
- MKE
1 stop13h 29m
Frontier
Deal found 4/10![Frontier logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sön 4/199:33 am
MKE
- CLT
1 stop21h 36m
Multiple Airlines
ons 4/298:09 pm
CLT
- MKE
1 stop16h 17m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sön 4/199:33 am
MKE
- CLT
1 stop21h 36m
Multiple Airlines
ons 4/229:32 pm
CLT
- MKE
1 stop14h 54m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tors 4/3012:21 pm
MKE
- CLT
1 stop7h 16m
Multiple Airlines
mån 5/48:09 pm
CLT
- MKE
1 stop13h 52m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$220
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mån 5/412:21 pm
MKE
- CHS
1 stop20h 12m
Multiple Airlines
ons 5/64:34 pm
CHS
- MKE
1 stop17h 27m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tis 5/59:56 am
MKE
- CLT
1 stop8h 17m
Frontier
ons 5/67:58 pm
CLT
- MKE
1 stop14h 03m
Frontier
Deal found 4/10![Frontier logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tis 5/59:56 am
MKE
- CLT
1 stop7h 56m
Multiple Airlines
ons 5/67:58 pm
CLT
- MKE
1 stop14h 03m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$224
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lör 5/96:00 am
MKE
- HHH
1 stop6h 40m
American Airlines
lör 5/166:50 pm
HHH
- MKE
1 stop4h 57m
American Airlines
Deal found 4/8![American Airlines logo]()
$261
This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tis 5/126:00 am
MKE
- CAE
1 stop7h 28m
American Airlines
lör 5/164:15 pm
CAE
- MKE
1 stop7h 12m
American Airlines
Deal found 4/9![American Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tors 5/149:46 am
MKE
- CLT
1 stop8h 06m
Multiple Airlines
mån 5/187:58 pm
CLT
- MKE
1 stop14h 03m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$200
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lör 5/306:10 pm
MKE
- CAE
1 stop4h 37m
Delta
lör 6/65:40 am
CAE
- MKE
1 stop6h 58m
Delta
Deal found 4/6![Delta logo]()
$271
One-way flights from Milwaukee to South CarolinaSearch for one-way flight options from Milwaukee to South Carolina. Find affordable one-way fares based on user searches. Data last updated april 11, 2026.
Search for one-way flight options from Milwaukee to South Carolina. Find affordable one-way fares based on user searches. Data last updated april 11, 2026.
This Frontier deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tis 5/59:56 am
MKE
- CLT
1 stop8h 17m
Frontier
Deal found 4/9![Frontier logo]()
$70
This Frontier deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tors 6/48:46 am
MKE
- CLT
1 stop6h 57m
Frontier
Deal found 4/6![Frontier logo]()
$90
This Frontier deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tis 6/98:43 am
MKE
- CLT
1 stop7h 00m
Frontier
Deal found 4/7![Frontier logo]()
$111
This Trip.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fre 4/177:34 pm
MKE
- CLT
1 stop20h 01m
Frontier
Deal found 4/9![Frontier logo]()
$114
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tors 4/1612:21 pm
MKE
- CLT
1 stop7h 16m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$121
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sön 5/109:56 am
MKE
- CLT
1 stop7h 56m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mån 5/412:21 pm
MKE
- CLT
1 stop29h 31m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mån 4/2012:21 pm
MKE
- CHS
1 stop19h 17m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tis 5/129:56 am
MKE
- CLT
2 stops24h 32m
Frontier
Deal found 4/10![Frontier logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tis 5/199:56 am
MKE
- MYR
1 stop22h 09m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$132
This Frontier deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tors 6/118:43 am
MKE
- CLT
1 stop6h 57m
Frontier
Deal found 4/10![Frontier logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
tors 4/1612:21 pm
MKE
- GSP
1 stop30h 17m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$138
Find flight deals from Milwaukee to South Carolina
Keep the following information in mind while searching for Milwaukee to South Carolina flight deals. Data was last updated april 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $184 (Kiwi.com) |
One-way from | $70 (Frontier) |
Popular in | March |
Cheapest in | January |
Average price | $412 |
Cheapflights Fare Finder
Customize your flight search to find flights from Milwaukee to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated april 11, 2026.
Use the filters below to find and compare flights from Milwaukee to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
MilwaukeeColumbia
MKE - CAE
MKECAE
Milwaukee-Mitchell
tis 5/12
6:00 am-2:28 pm
1 stop7h 28m
Columbia Metropolitan
lör 5/16
4:15 pm-10:27 pm
1 stop7h 12m
$261
MilwaukeeHilton Head Island
MKE - HHH
MKEHHH
Milwaukee-Mitchell
tis 7/28
10:11 am-3:29 pm
1 stop4h 18m
Hilton Head Island
tis 8/4
12:11 pm-4:31 pm
1 stop5h 20m
$261
MilwaukeeHilton Head Island
MKE - HHH
MKEHHH
Milwaukee-Mitchell
mån 5/11
10:13 am-3:33 pm
1 stop4h 20m
Hilton Head Island
tis 5/19
12:18 pm-4:12 pm
1 stop4h 54m
$276
MilwaukeeHilton Head Island
MKE - HHH
MKEHHH
Milwaukee-Mitchell
ons 7/15
10:11 am-3:29 pm
1 stop4h 18m
Hilton Head Island
tis 7/21
4:12 pm-10:30 pm
1 stop7h 18m
$281
MilwaukeeColumbia
MKE - CAE
MKECAE
Milwaukee-Mitchell
ons 5/13
5:23 am-11:11 am
1 stop4h 48m
Columbia Metropolitan
mån 5/18
3:53 pm-9:02 pm
1 stop6h 09m
$286
MilwaukeeColumbia
MKE - CAE
MKECAE
Milwaukee-Mitchell
lör 5/16
5:23 am-11:11 am
1 stop4h 48m
Columbia Metropolitan
sön 5/17
5:38 am-9:08 am
1 stop4h 30m
$286
MilwaukeeMyrtle Beach
MKE - MYR
MKEMYR
Milwaukee-Mitchell
mån 6/1
4:18 pm-11:58 pm
1 stop6h 40m
Myrtle Beach Intl
tis 6/9
1:51 pm-7:17 pm
1 stop6h 26m
$291
MilwaukeeMyrtle Beach
MKE - MYR
MKEMYR
Milwaukee-Mitchell
sön 5/24
6:10 pm-11:58 pm
1 stop4h 48m
Myrtle Beach Intl
fre 5/29
11:43 am-3:12 pm
1 stop4h 29m
$291
MilwaukeeMyrtle Beach
MKE - MYR
MKEMYR
Milwaukee-Mitchell
fre 5/1
3:30 pm-8:50 pm
1 stop4h 20m
Myrtle Beach Intl
mån 5/4
3:45 pm-11:25 pm
1 stop8h 40m
$296
MilwaukeeColumbia
MKE - CAE
MKECAE
Milwaukee-Mitchell
tors 7/2
10:08 am-3:09 pm
1 stop4h 01m
Columbia Metropolitan
tors 7/9
5:35 am-9:06 am
1 stop4h 31m
$301
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Milwaukee to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Milwaukee with our price prediction graph.
MKE-CAE
MKE-HHH
MKE-MYR
MKE-CHS
MKE-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Milwaukee to South Carolina
MKE-USSC
MKE-CAE
MKE-HHH
MKE-MYR
MKE-CHS
What is the cheapest month to book a flight from Milwaukee to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $60). Flying from Milwaukee to South Carolina in April is currently the most expensive (average of $212). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MKE to SC?
Find hourly flight availability from Milwaukee to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated april 11, 2026.
It’s typically best to fly out from Milwaukee to South Carolina in the evening. Doing so could potentially save you 37% on the flight price compared to flying in the afternoon, which is usually more expensive.
What is the cheapest day to fly from Milwaukee to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Milwaukee to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Milwaukee to South Carolina flight should consider departing on Friday evenings when fares are most often at their lowest. Saturday evenings flights should be avoided if possible as fares are typically the most expensive at this time.
How much does it cost to fly round-trip from Milwaukee to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated april 11, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Milwaukee to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Milwaukee to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Milwaukee to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Milwaukee to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Milwaukee and South Carolina flights
Browse other Milwaukee and South Carolina flight options. Last updated on april 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Milwaukee to South Carolina flights
Consider these flights traveling from Milwaukee to South Carolina.
Top 5 airlines flying from Milwaukee to South Carolina
Discover the top 5 airlines that operate flights from Milwaukee to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated april 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$193 | Average$198 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$198 | Average$361 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$201 | Average$409 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$203 | Average$377 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$412 | FlexibilityNo cancel fee | On-time69% |