How long is the flight from Milwaukee to South Carolina?

Southwest, Delta, and American Airlines can get you from Milwaukee to South Carolina in just under 3h 43m. Your travel time can differ by up to 1h 22m. There are 634 mi between Milwaukee and South Carolina. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines to fly from Milwaukee to South Carolina one-way?

For one-way options, check prices for Southwest. According to our data, you can fly for as low as $105. Users have also found prices from $115 and $118 on Frontier and Sun Country Air, respectively.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

What are the most popular routes from Milwaukee to South Carolina?

While some choose either Milwaukee-Mitchell - Charleston or Milwaukee-Mitchell - Myrtle Beach Intl, Milwaukee-Mitchell - Charlotte Douglas is the most popular route from Milwaukee to South Carolina.

What are the most popular airlines that fly from Milwaukee to South Carolina?

Consider American Airlines, Delta or Sun Country Air when booking your flight. These represent the most popular airlines when flying from Milwaukee to South Carolina.

What airport do you fly from for flights from Milwaukee to South Carolina?

Milwaukee-Mitchell (MKE), located 6.4 mi from the city center, is the airport you fly out of when you book flights from Milwaukee to South Carolina.

Can I find deals for flights from Milwaukee to South Carolina that include hotel bookings?

Yes. In addition to deals on Milwaukee to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Milwaukee to South Carolina?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Milwaukee to South Carolina.

Can I find deals for business class flights from Milwaukee to South Carolina?

Yes. Cheapflights offers flight deals from Milwaukee to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$105+ Flights from Milwaukee to South Carolina

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Cheap flight deals from Milwaukee to South Carolina

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$210 (Southwest)
One-way from	$105 (Southwest)
Popular in	March
Cheapest in	January
Average price	$325

Provider with most accurate pricing for Milwaukee-Mitchell-Myrtle Beach Intl flight deals.

Search Deals

Provider most trusted by Cheapflights users for Milwaukee-Mitchell-Myrtle Beach Intl flights.

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From Milwaukee-Mitchell to South Carolina

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One-way flight from Milwaukee-Mitchell to South Carolina

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Highest demand for flights based on searches. 8% potential increase in price ($34 potential increase over avg. RT price).

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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).

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Average for round-trip flights in October 2025

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Find flight deals from Milwaukee to South Carolina

Cheapest flights from Milwaukee to South Carolina
Explore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2025.

Tue 12/1612:45 pmMKE - CHS

1 stop6h 50mSouthwest

Sat 1/1011:05 amCHS - MKE

1 stop6h 55mSouthwest

Deal found 10/22

$223

Mon 12/811:02 amMKE - CLT

1 stop7h 10mSpirit Airlines

Thu 12/118:07 pmCLT - MKE

1 stop14h 50mSpirit Airlines

Deal found 10/22

$240

Tue 12/26:29 amMKE - HHH

1 stop5h 01mAmerican Airlines

Sat 12/66:48 pmHHH - MKE

1 stop6h 13mAmerican Airlines

Deal found 10/23

$249

Sat 12/63:17 pmMKE - CHS

1 stop5h 28mDelta

Sat 12/137:00 amCHS - MKE

1 stop4h 46mDelta

Deal found 10/22

$251

Wed 12/31:19 pmMKE - GSP

1 stop7h 45mDelta

Mon 12/87:36 pmGSP - MKE

1 stop5h 18mDelta

Deal found 10/21

$255

Sat 12/66:14 amMKE - CHS

1 stop5h 14mAmerican Airlines

Sat 12/135:10 amCHS - MKE

2 stops6h 34mAmerican Airlines

Deal found 10/22

$256

Fri 11/76:05 amMKE - CAE

1 stop6h 42mUnited Airlines

Tue 11/1110:20 amCAE - MKE

1 stop5h 47mUnited Airlines

Deal found 10/23

$259

Wed 12/36:00 amMKE - GSP

2 stops7h 17mUnited Airlines

Mon 12/85:28 pmGSP - MKE

1 stop4h 19mUnited Airlines

Deal found 10/21

$260

Thu 11/202:35 pmMKE - MYR

1 stop4h 10mSouthwest

Sat 12/61:15 pmMYR - MKE

1 stop6h 40mSouthwest

Deal found 10/22

$262

Thu 12/46:01 amMKE - CLT

1 stop8h 15mAmerican Airlines

Mon 12/84:14 pmCLT - MKE

1 stop8h 16mAmerican Airlines

Deal found 10/21

$265

Mon 12/225:50 pmMKE - CHS

1 stop5h 08mDelta

Tue 1/65:30 amCHS - MKE

1 stop4h 57mDelta

Deal found 10/21

$268

Mon 12/811:02 amMKE - CLT

1 stop7h 10mSpirit Airlines

Wed 12/1012:59 pmCLT - MKE

2 stops21h 58mSpirit Airlines

Deal found 10/22

$272

Best flights from Milwaukee to South Carolina
Discover carefully curated flight deals from Milwaukee to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 23, 2025.

Sat 1/242:05 pmMKE - SAV

1 stop5h 05mSouthwest

Wed 1/2811:15 amSAV - MKE

2 stops8h 10mSouthwest

Deal found 10/20

$215

Wed 1/141:00 pmMKE - GSP

1 stop3h 43mDelta

Tue 1/207:15 amGSP - MKE

1 stop6h 16mDelta

Deal found 10/21

$239

Tue 12/26:29 amMKE - HHH

1 stop5h 01mAmerican Airlines

Sat 12/62:17 pmHHH - MKE

1 stop4h 47mAmerican Airlines

Deal found 10/21

$249

Sat 1/248:33 amMKE - SAV

1 stop5h 02mUnited Airlines

Wed 1/2810:10 amSAV - MKE

1 stop4h 43mUnited Airlines

Deal found 10/20

$251

Mon 12/811:02 amMKE - CLT

1 stop7h 10mSpirit Airlines

Wed 12/1012:59 pmCLT - MKE

2 stops21h 58mSpirit Airlines

Deal found 10/22

$272

Thu 1/221:56 pmMKE - SAV

2 stops21h 52mMultiple Airlines

Sun 1/258:00 amSAV - MKE

2 stops29h 36mMultiple Airlines

Deal found 10/21

$296

Tue 12/1612:45 pmMKE - CHS

1 stop6h 50mSouthwest

Sat 1/1011:05 amCHS - MKE

1 stop6h 55mSouthwest

Deal found 10/22

$223

Wed 1/147:00 amMKE - GSP

1 stop5h 54mDelta

Sun 1/186:45 amGSP - MKE

1 stop5h 33mDelta

Deal found 10/21

$243

Wed 12/176:00 amMKE - CHS

2 stops10h 05mSouthwest

Sat 1/1011:05 amCHS - MKE

1 stop6h 55mSouthwest

Deal found 10/22

$228

Wed 2/251:25 pmMKE - SAV

1 stop5h 35mUnited Airlines

Sat 2/284:47 pmSAV - MKE

1 stop5h 57mUnited Airlines

Deal found 10/21

$251

Mon 12/226:27 pmMKE - CHS

1 stop4h 38mAmerican Airlines

Tue 1/66:10 amCHS - MKE

2 stops5h 52mAmerican Airlines

Deal found 10/22

$273

Sat 1/2410:25 amMKE - SAV

1 stop4h 09mDelta

Wed 1/285:30 amSAV - MKE

1 stop4h 57mDelta

Deal found 10/22

$251

Wed 1/215:00 amMKE - CHS

1 stop6h 32mUnited Airlines

Wed 1/214:41 pmCHS - MKE

1 stop6h 18mUnited Airlines

Deal found 10/22

$251

Fri 1/231:56 pmMKE - CLT

2 stops17h 41mSpirit Airlines

Mon 1/265:45 amCLT - MKE

2 stops8h 06mSpirit Airlines

Deal found 10/22

$292

Wed 12/31:19 pmMKE - GSP

1 stop7h 45mDelta

Mon 12/87:36 pmGSP - MKE

1 stop5h 18mDelta

Deal found 10/21

$255

Fri 11/76:05 amMKE - CAE

1 stop6h 42mUnited Airlines

Tue 11/1110:20 amCAE - MKE

1 stop5h 47mUnited Airlines

Deal found 10/23

$259

Thu 11/202:35 pmMKE - MYR

1 stop4h 10mSouthwest

Sat 12/61:15 pmMYR - MKE

1 stop6h 40mSouthwest

Deal found 10/22

$262

Mon 11/246:00 amMKE - MYR

1 stop5h 13mAmerican Airlines

Tue 12/27:41 pmMYR - MKE

1 stop4h 15mAmerican Airlines

Deal found 10/21

$289

Thu 1/155:45 amMKE - GSP

1 stop4h 15mDelta

Tue 1/2011:55 amGSP - MKE

1 stop6h 15mDelta

Deal found 10/21

$255

Wed 12/36:00 amMKE - GSP

2 stops7h 17mUnited Airlines

Mon 12/85:28 pmGSP - MKE

1 stop4h 19mUnited Airlines

Deal found 10/21

$260

Sun 12/710:34 amMKE - MYR

1 stop25h 46mSpirit Airlines

Fri 12/126:59 pmMYR - MKE

2 stops39h 58mSpirit Airlines

Deal found 10/23

$315

Mon 12/85:00 amMKE - MYR

2 stops8h 44mAmerican Airlines

Thu 12/115:00 amMYR - MKE

2 stops8h 04mAmerican Airlines

Deal found 10/21

$295

Mon 12/226:10 amMKE - CLT

1 stop9h 50mSouthwest

Tue 12/308:05 pmCLT - MKE

1 stop4h 40mSouthwest

Deal found 10/21

$277

Wed 1/142:00 pmMKE - GSP

1 stop7h 18mDelta

Mon 1/197:55 pmGSP - MKE

1 stop4h 32mDelta

Deal found 10/21

$255

Mon 12/82:30 pmMKE - CHS

2 stops8h 12mUnited Airlines

Sat 12/134:38 pmCHS - MKE

1 stop6h 52mUnited Airlines

Deal found 10/21

$273

Fri 12/52:35 pmMKE - GSP

1 stop4h 05mSouthwest

Tue 12/94:45 pmGSP - MKE

1 stop6h 00mSouthwest

Deal found 10/22

$279

Sat 12/65:00 amMKE - MYR

2 stops7h 59mAmerican Airlines

Sun 12/142:44 pmMYR - MKE

1 stop4h 20mAmerican Airlines

Deal found 10/23

$307

Thu 1/155:45 amMKE - GSP

1 stop4h 15mDelta

Sun 1/186:45 amGSP - MKE

1 stop5h 33mDelta

Deal found 10/21

$259

Thu 1/155:00 amMKE - GSP

2 stops8h 19mUnited Airlines

Mon 1/195:34 pmGSP - MKE

1 stop4h 14mUnited Airlines

Deal found 10/21

$276

Sun 12/78:53 amMKE - CLT

1 stop9h 21mAmerican Airlines

Fri 12/1210:30 pmCLT - MKE

1 stop10h 47mAmerican Airlines

Deal found 10/22

$313

Last-minute flights from Milwaukee to South Carolina
Discover last-minute flight deals from Milwaukee to South Carolina. Data last updated October 23, 2025 and is based on user searches.

Fri 10/248:16 pmMKE - CLT

1 stop11h 07mAmerican Airlines

Sat 10/2511:46 amCLT - MKE

Nonstop2h 14mAmerican Airlines

Deal found 10/21

$310

Fri 10/312:04 pmMKE - CAE

1 stop3h 58mDelta

Sun 11/25:00 amCAE - MKE

1 stop7h 29mDelta

Deal found 10/23

$289

Thu 11/67:11 amMKE - CAE

1 stop6h 07mDelta

Sun 11/95:37 amCAE - MKE

1 stop4h 44mDelta

Deal found 10/23

$309

Fri 11/76:05 amMKE - CAE

1 stop6h 42mUnited Airlines

Tue 11/1110:20 amCAE - MKE

1 stop5h 47mUnited Airlines

Deal found 10/23

$259

Fri 11/71:25 pmMKE - CAE

1 stop6h 55mDelta

Sun 11/95:37 amCAE - MKE

1 stop4h 44mDelta

Deal found 10/22

$314

Wed 11/123:13 pmMKE - SAV

1 stop6h 24mDelta

Sat 11/157:30 amSAV - MKE

1 stop4h 12mDelta

Deal found 10/21

$313

Sat 11/157:00 amMKE - CHS

1 stop5h 05mDelta

Tue 11/183:47 pmCHS - MKE

1 stop5h 31mDelta

Deal found 10/22

$313

Thu 11/202:35 pmMKE - MYR

1 stop4h 10mSouthwest

Sat 12/61:15 pmMYR - MKE

1 stop6h 40mSouthwest

Deal found 10/22

$262

Thu 11/206:00 amMKE - CHS

1 stop7h 03mDelta

Thu 11/2710:40 amCHS - MKE

1 stop6h 37mDelta

Deal found 10/23

$287

Mon 11/246:00 amMKE - CAE

1 stop8h 05mDelta

Thu 11/2712:56 pmCAE - MKE

1 stop4h 21mDelta

Deal found 10/21

$284

Mon 11/246:00 amMKE - MYR

1 stop5h 13mAmerican Airlines

Tue 12/27:41 pmMYR - MKE

1 stop4h 15mAmerican Airlines

Deal found 10/21

$289

Wed 11/266:48 pmMKE - MYR

1 stop4h 07mAmerican Airlines

Wed 12/37:37 pmMYR - MKE

1 stop4h 24mAmerican Airlines

Deal found 10/22

$315

One-way flights from Milwaukee to South Carolina
Search for one-way flight options from Milwaukee to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 23, 2025.

Sat 12/61:10 pmMKE - SAV

1 stop3h 45mSouthwest

Deal found 10/22

$105

Sat 12/65:45 amMKE - CHS

1 stop6h 00mSouthwest

Deal found 10/21

$105

Sun 11/236:30 pmMKE - CLT

1 stop22h 26mSun Country Air

Deal found 10/22

$118

Wed 1/215:30 amMKE - CLT

2 stops9h 50mSouthwest

Deal found 10/22

$123

Sat 12/66:14 amMKE - CHS

1 stop5h 14mAmerican Airlines

Deal found 10/22

$125

Tue 2/172:00 pmMKE - SAV

1 stop7h 34mDelta

Deal found 10/23

$126

Wed 1/2110:25 amMKE - CHS

1 stop6h 34mDelta

Deal found 10/23

$126

Thu 11/2012:35 pmMKE - CLT

1 stop6h 22mSpirit Airlines

Deal found 10/22

$130

Wed 1/211:04 pmMKE - CHS

2 stops7h 04mAmerican Airlines

Deal found 10/23

$131

Tue 1/205:30 amMKE - CLT

2 stops9h 50mSouthwest

Deal found 10/21

$141

Sun 11/236:30 pmMKE - CLT

2 stops20h 02mMultiple Airlines

Deal found 10/22

$142

Mon 12/155:11 pmMKE - MYR

1 stop5h 32mDelta

Deal found 10/22

$143

Cheapflights Fare Finder

Use the filters below to find and compare flights from Milwaukee to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MilwaukeeSavannah

MKE - SAV

MKESAV

Milwaukee-Mitchell

Sat 1/24

2:05 pm-8:10 pm

1 stop5h 05m

Savannah/Hilton Head

Wed 1/28

11:15 am-6:25 pm

2 stops8h 10m

$215

MilwaukeeCharleston

MKE - CHS

MKECHS

Milwaukee-Mitchell

Tue 12/16

12:45 pm-8:35 pm

1 stop6h 50m

Charleston

Sat 1/10

11:05 am-5:00 pm

1 stop6h 55m

$223

MilwaukeeCharleston

MKE - CHS

MKECHS

Milwaukee-Mitchell

Wed 12/17

6:00 am-5:05 pm

2 stops10h 05m

Charleston

Sat 1/10

11:05 am-5:00 pm

1 stop6h 55m

$228

MilwaukeeGreenville

MKE - GSP

MKEGSP

Milwaukee-Mitchell

Wed 1/14

1:00 pm-5:43 pm

1 stop3h 43m

Greenville

Tue 1/20

7:15 am-12:31 pm

1 stop6h 16m

$239

MilwaukeeGreenville

MKE - GSP

MKEGSP

Milwaukee-Mitchell

Wed 1/14

7:00 am-1:54 pm

1 stop5h 54m

Greenville

Sun 1/18

6:45 am-11:18 am

1 stop5h 33m

$243

MilwaukeeHilton Head Island

MKE - HHH

MKEHHH

Milwaukee-Mitchell

Tue 12/2

6:29 am-12:30 pm

1 stop5h 01m

Hilton Head Island

Sat 12/6

2:17 pm-6:04 pm

1 stop4h 47m

$249

MilwaukeeSavannah

MKE - SAV

MKESAV

Milwaukee-Mitchell

Sat 1/24

8:33 am-2:35 pm

1 stop5h 02m

Savannah/Hilton Head

Wed 1/28

10:10 am-1:53 pm

1 stop4h 43m

$251

MilwaukeeSavannah

MKE - SAV

MKESAV

Milwaukee-Mitchell

Wed 2/25

1:25 pm-8:00 pm

1 stop5h 35m

Savannah/Hilton Head

Sat 2/28

4:47 pm-9:44 pm

1 stop5h 57m

$251

MilwaukeeSavannah

MKE - SAV

MKESAV

Milwaukee-Mitchell

Sat 1/24

10:25 am-3:34 pm

1 stop4h 09m

Savannah/Hilton Head

Wed 1/28

5:30 am-9:27 am

1 stop4h 57m

$251

MilwaukeeCharleston

MKE - CHS

MKECHS

Milwaukee-Mitchell

Wed 1/21

5:00 am-12:32 pm

1 stop6h 32m

Charleston

Wed 1/21

4:41 pm-9:59 pm

1 stop6h 18m

$251

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/22

Showing 1-10 of 60 results

...

Best time to book a flight from Milwaukee to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Milwaukee with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Milwaukee to South Carolina

What is the cheapest month to book a flight from Milwaukee to South Carolina?

Currently, July is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $60). Flying from Milwaukee to South Carolina in December is currently the most expensive (average of $189). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MKE to SC?

It’s typically best to fly out from Milwaukee to South Carolina in the evening. Doing so could potentially save you 32% on the flight price compared to flying at noon, which is usually more expensive.

What is the cheapest day to fly from Milwaukee to South Carolina?

Travelers seeking maximum savings on their Milwaukee to South Carolina flight should consider departing on Friday evenings when fares are most often at their lowest. Saturday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

See what other customers who have flown with Southwest, Delta, and United Airlines from Milwaukee to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,236 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Southwest

8.0

Very good

4,236 reviews

Southwest

8.0

Very good

4,236 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Delta

7.9

Good

7,982 reviews

Southwest

8.0

Very good

4,236 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

United Airlines

7.4

Good

8,995 reviews

Southwest

8.0

Very good

4,236 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

American Airlines

7.2

Good

11,033 reviews

Southwest

8.0

Very good

4,236 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Spirit Airlines

6.3

Okay

8,103 reviews

Southwest

8.0

Very good

4,236 reviews

Reviews

1 / 20

2.0

Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

What airport do you fly from for flights from Milwaukee to South Carolina?
Milwaukee-Mitchell (MKE), located 6.4 mi from the city center, is the airport you fly out of when you book flights from Milwaukee to South Carolina.
How long is the flight from Milwaukee to South Carolina?
Southwest, Delta, and American Airlines can get you from Milwaukee to South Carolina in just under 3h 43m. Your travel time can differ by up to 1h 22m. There are 634 mi between Milwaukee and South Carolina. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines to fly from Milwaukee to South Carolina one-way?
For one-way options, check prices for Southwest. According to our data, you can fly for as low as $105. Users have also found prices from $115 and $118 on Frontier and Sun Country Air, respectively.
What are the most popular routes from Milwaukee to South Carolina?
While some choose either Milwaukee-Mitchell - Charleston or Milwaukee-Mitchell - Myrtle Beach Intl, Milwaukee-Mitchell - Charlotte Douglas is the most popular route from Milwaukee to South Carolina.
Can I find deals for flights from Milwaukee to South Carolina that include hotel bookings?
Yes. In addition to deals on Milwaukee to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Milwaukee to South Carolina?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Milwaukee to South Carolina.
Can I find deals for business class flights from Milwaukee to South Carolina?
Yes. Cheapflights offers flight deals from Milwaukee to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Milwaukee to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $60). Flying from Milwaukee to South Carolina in December is currently the most expensive (average of $189). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

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Top 5 airlines flying from Milwaukee to South Carolina

Airline	Cheapest	Average	Flexibility	On-time
Spirit Airlines	Cheapest$141	Average$239	FlexibilityNo cancel fee	On-time65%
American Airlines	Cheapest$228	Average$377	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$228	Average$362	FlexibilityNo cancel fee	On-timeN/A
Southwest	Cheapest$256	Average$401	FlexibilityNo cancel fee	On-time63%
United Airlines	Cheapest$280	Average$398	FlexibilityNo cancel fee	On-time69%

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$105+ Cheap flights from Milwaukee (MKE) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/6. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Milwaukee to South Carolina

Keep the following information in mind while searching for Milwaukee to South Carolina flight deals. Data was last updated October 23, 2025.

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Find flight deals from Milwaukee to South Carolina

Cheapest flights from Milwaukee to South CarolinaExplore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2025.

Explore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2025.

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Use the filters below to find and compare flights from Milwaukee to South Carolina that are best for you.

Best time to book a flight from Milwaukee to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Milwaukee with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Milwaukee to South Carolina

What is the cheapest month to book a flight from Milwaukee to South Carolina?

What is the cheapest time of day to fly from MKE to SC?

Find hourly flight availability from Milwaukee to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 23, 2025.

What is the cheapest day to fly from Milwaukee to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Milwaukee to South Carolina. Price data was last updated on December 16, 2024.

Reviews of airlines servicing South Carolina

See what other customers who have flown with Southwest, Delta, and United Airlines from Milwaukee to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Milwaukee to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

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What are the cheapest airlines to fly from Milwaukee to South Carolina one-way?

What are the most popular routes from Milwaukee to South Carolina?

Can I find deals for flights from Milwaukee to South Carolina that include hotel bookings?

How can I find direct flights from Milwaukee to South Carolina?

Can I find deals for business class flights from Milwaukee to South Carolina?

What is the cheapest month to book a flight from Milwaukee to South Carolina?

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Alternative routes for Milwaukee to South Carolina

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Top 5 airlines flying from Milwaukee to South Carolina

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Cheapest flights from Milwaukee to South Carolina
Explore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2025.