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South Carolina

$70+ Cheap flights from Milwaukee (MKE) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.
MKE — CHS
Jan 25 — Feb 11
Sun 1/25
Sun 2/1
1 adult, Economy
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Cheap flight deals from Milwaukee to South Carolina

Cheapest flights from Milwaukee to South Carolina
Explore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 26, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:15 pmMKE - CLT
2 stops26h 14mMultiple Airlines
Wed 1/74:32 pmCLT - MKE
1 stop27h 13mMultiple Airlines
Deal found 12/24$356
This Delta deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:38 pmMKE - CLT
1 stop7h 08mDelta
Thu 1/14:05 pmCLT - MKE
1 stop5h 30mDelta
Deal found 12/24$359
This Kiwi.com deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:15 pmMKE - CLT
1 stop16h 12mMultiple Airlines
Sun 1/49:34 pmCLT - MKE
2 stops13h 19mMultiple Airlines
Deal found 12/24$400
This American Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:10 amMKE - CLT
Nonstop2h 11mAmerican Airlines
Wed 12/314:37 pmCLT - MKE
Nonstop2h 05mAmerican Airlines
Deal found 12/25$408
This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:10 amMKE - CLT
Nonstop2h 11mAmerican Airlines
Tue 12/302:52 pmCLT - MKE
1 stop3h 57mAmerican Airlines
Deal found 12/24$418
This Delta deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:40 amMKE - CLT
1 stop4h 13mDelta
Tue 12/306:00 amCLT - MKE
1 stop4h 33mDelta
Deal found 12/24$428
This United Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:00 amMKE - CLT
1 stop4h 31mUnited Airlines
Wed 12/3111:15 amCLT - MKE
2 stops10h 56mUnited Airlines
Deal found 12/25$433
This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:10 amMKE - HHH
1 stop6h 06mAmerican Airlines
Wed 12/312:46 pmHHH - MKE
2 stops9h 14mAmerican Airlines
Deal found 12/24$461
This Delta deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:40 amMKE - CLT
1 stop4h 13mDelta
Fri 1/24:05 pmCLT - MKE
1 stop5h 30mDelta
Deal found 12/24$463
This Kiwi.com deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:15 pmMKE - CLT
1 stop16h 12mMultiple Airlines
Thu 1/17:19 pmCLT - MKE
2 stops15h 34mMultiple Airlines
Deal found 12/24$469
This Kiwi.com deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:21 pmMKE - CLT
1 stop17h 35mMultiple Airlines
Sun 1/49:34 pmCLT - MKE
2 stops13h 19mMultiple Airlines
Deal found 12/24$473
This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:10 amMKE - CLT
Nonstop2h 11mAmerican Airlines
Mon 12/2910:55 pmCLT - MKE
Nonstop2h 03mAmerican Airlines
Deal found 12/24$478

Find flight deals from Milwaukee to South Carolina

Keep the following information in mind while searching for Milwaukee to South Carolina flight deals. Data was last updated December 26, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$165
(Kiwi.com)

One-way from

$70
(Frontier)

Popular in

March

Cheapest in

January

Average price

$446
Provider with most accurate pricing for Milwaukee-Mitchell-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Milwaukee-Mitchell-Myrtle Beach Intl flights.
Search Deals
From Milwaukee-Mitchell to South Carolina
Search Deals
One-way flight from Milwaukee-Mitchell to South Carolina
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($38 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Milwaukee to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 26, 2025.
Use the filters below to find and compare flights from Milwaukee to South Carolina that are best for you.

Fly from

Milwaukee

Fly to

South Carolina

Route

Depart

Return

Price

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Tue 2/3

6:53 pm-4:54 pm

1 stop21h 01m

Charlotte Douglas

Fri 2/6

11:12 am-6:33 pm

1 stop8h 21m

$165

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Mon 1/26

7:01 pm-4:54 pm

1 stop20h 53m

Charlotte Douglas

Fri 1/30

6:01 pm-6:53 pm

1 stop25h 52m

$165

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Sat 1/31

7:48 pm-10:17 am

1 stop13h 29m

Charlotte Douglas

Wed 2/11

7:43 pm-7:40 am

2 stops12h 57m

$228

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Tue 4/28

5:10 am-10:06 am

1 stop3h 56m

Columbia Metropolitan

Tue 5/5

5:25 pm-8:48 pm

1 stop4h 23m

$269

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Thu 2/12

12:07 pm-7:06 pm

1 stop5h 59m

Columbia Metropolitan

Sun 2/15

7:22 am-11:37 am

1 stop5h 15m

$274

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Tue 4/28

12:13 pm-7:12 pm

1 stop5h 59m

Columbia Metropolitan

Tue 5/5

6:33 pm-10:57 pm

2 stops5h 24m

$274

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

Sat 1/17

9:30 am-11:16 am

1 stop24h 46m

Charlotte Douglas

Sun 1/18

2:13 pm-3:20 pm

Nonstop2h 07m

$275

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Thu 1/8

10:30 am-4:26 pm

1 stop4h 56m

Columbia Metropolitan

Mon 1/12

5:07 pm-9:59 pm

1 stop5h 52m

$279

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Sat 1/10

3:53 pm-10:58 pm

1 stop6h 05m

Columbia Metropolitan

Sun 1/11

7:20 am-12:21 pm

1 stop6h 01m

$279

MilwaukeeHilton Head Island

MKE - HHH

MKEHHH

Milwaukee-Mitchell

Tue 4/28

7:26 am-12:17 pm

1 stop3h 51m

Hilton Head Island

Tue 5/5

6:07 pm-9:12 pm

1 stop4h 05m

$283

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/25

Showing 1-10 of 60 results
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Best time to book a flight from Milwaukee to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Milwaukee with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Milwaukee to South Carolina

What is the cheapest month to book a flight from Milwaukee to South Carolina?

Currently, July is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $60). Flying from Milwaukee to South Carolina in December is currently the most expensive (average of $202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MKE to SC?

Find hourly flight availability from Milwaukee to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 26, 2025.

It’s typically best to fly out from Milwaukee to South Carolina in the evening. Doing so could potentially save you 32% on the flight price compared to flying at noon, which is usually more expensive.

What is the cheapest day to fly from Milwaukee to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Milwaukee to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Milwaukee to South Carolina flight should consider departing on Friday evenings when fares are most often at their lowest. Saturday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 26, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Milwaukee to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,258 reviews

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,258 reviews
Southwest
8.0
Very good
4,258 reviews

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,018 reviews
Southwest
8.0
Very good
4,258 reviews

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,116 reviews
Southwest
8.0
Very good
4,258 reviews

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,068 reviews
Southwest
8.0
Very good
4,258 reviews

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Spirit Airlines
6.3
Okay
8,210 reviews
Southwest
8.0
Very good
4,258 reviews

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Milwaukee to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Milwaukee to South Carolina?

    Milwaukee-Mitchell (MKE), located 6.4 mi from the city center, is the airport you fly out of when you book flights from Milwaukee to South Carolina.

  • How long is the flight from Milwaukee to South Carolina?

    United Airlines, American Airlines, and Delta can get you from Milwaukee to South Carolina in just under 3h 56m. Your travel time can differ by up to 2h 03m. There are 721 mi between Milwaukee and South Carolina. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Milwaukee to South Carolina one-way?

    For one-way options, check prices for Sun Country Air. According to our data, you can fly for as low as $107. Users have also found prices from $155 and $155 on Aeromexico and Delta, respectively.

  • What are the most popular routes from Milwaukee to South Carolina?

    While some choose either Milwaukee-Mitchell - Charlotte Douglas or Milwaukee-Mitchell - Charleston, Milwaukee-Mitchell - Myrtle Beach Intl is the most popular route from Milwaukee to South Carolina.

  • Can I find deals for flights from Milwaukee to South Carolina that include hotel bookings?

    Yes. In addition to deals on Milwaukee to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Milwaukee to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Milwaukee to South Carolina.

  • Can I find deals for business class flights from Milwaukee to South Carolina?

    Yes. Cheapflights offers flight deals from Milwaukee to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Milwaukee to South Carolina?

    Currently, July is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $60). Flying from Milwaukee to South Carolina in December is currently the most expensive (average of $202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Milwaukee to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Milwaukee to South Carolina

Discover the top 5 airlines that operate flights from Milwaukee to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$141Average$239FlexibilityNo cancel feeOn-time65%
SouthwestCheapest$201Average$401FlexibilityNo cancel feeOn-time63%
DeltaCheapest$216Average$358FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$370FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$394FlexibilityNo cancel feeOn-time69%

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