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South Carolina

$76+ Cheap flights from Milwaukee (MKE) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/18. Fares are subject to change and may not be available on all flights or dates of travel.
MKE — CHS
abr. 28 — may. 51
mar. 4/28
mar. 5/5
1 adult, Economy
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Cheap flight deals from Milwaukee to South Carolina

Cheapest flights from Milwaukee to South Carolina
Explore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on marzo 29, 2026.

This Frontier deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 4/269:33 am
MKE
-
CLT
1 stop7h 51m
Frontier
lun. 5/48:09 pm
CLT
-
MKE
1 stop12h 52m
Frontier
Deal found 3/27$201
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 4/2012:21 pm
MKE
-
CLT
1 stop27h 14m
Frontier
sáb. 4/258:09 pm
CLT
-
MKE
1 stop13h 29m
Frontier
Deal found 3/25$229
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 4/206:23 pm
MKE
-
CLT
2 stops21h 12m
Frontier
mié. 4/298:09 pm
CLT
-
MKE
1 stop16h 17m
Frontier
Deal found 3/25$235
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 4/2012:21 pm
MKE
-
CLT
1 stop27h 14m
Frontier
mié. 4/228:09 pm
CLT
-
MKE
1 stop16h 17m
Frontier
Deal found 3/24$237
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/246:29 pm
MKE
-
CLT
2 stops35h 36m
Frontier
mié. 4/298:09 pm
CLT
-
MKE
1 stop16h 17m
Frontier
Deal found 3/25$240
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 5/412:21 pm
MKE
-
CLT
1 stop29h 31m
Multiple Airlines
lun. 5/187:58 pm
CLT
-
MKE
1 stop13h 03m
Multiple Airlines
Deal found 3/27$244
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 4/2712:21 pm
MKE
-
CLT
1 stop7h 16m
Multiple Airlines
mié. 5/67:58 pm
CLT
-
MKE
1 stop13h 03m
Multiple Airlines
Deal found 3/27$245
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 4/269:33 am
MKE
-
CLT
1 stop21h 36m
Multiple Airlines
sáb. 5/28:09 pm
CLT
-
MKE
1 stop13h 29m
Multiple Airlines
Deal found 3/27$247
This Frontier deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 3/279:01 pm
MKE
-
CLT
1 stop10h 59m
Frontier
lun. 3/3010:11 am
CLT
-
MKE
1 stop7h 51m
Frontier
Deal found 3/25$250
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/54:30 pm
MKE
-
GSP
1 stop4h 10m
Southwest
mié. 5/66:45 am
GSP
-
MKE
1 stop4h 45m
Southwest
Deal found 3/24$251
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 4/199:33 am
MKE
-
CLT
1 stop21h 36m
Multiple Airlines
sáb. 4/258:09 pm
CLT
-
MKE
1 stop13h 29m
Multiple Airlines
Deal found 3/25$253
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 5/412:21 pm
MKE
-
CLT
1 stop29h 31m
Multiple Airlines
sáb. 5/167:58 pm
CLT
-
MKE
1 stop13h 03m
Multiple Airlines
Deal found 3/27$255

Find flight deals from Milwaukee to South Carolina

Keep the following information in mind while searching for Milwaukee to South Carolina flight deals. Data was last updated marzo 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$201
(Frontier)

One-way from

$76
(Frontier)

Popular in

March

Cheapest in

January

Average price

$461
Provider with most accurate pricing for Milwaukee-Mitchell-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Milwaukee-Mitchell-Myrtle Beach Intl flights.
Search Deals
From Milwaukee-Mitchell to South Carolina
Search Deals
One-way flight from Milwaukee-Mitchell to South Carolina
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($48 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Milwaukee to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated marzo 29, 2026.
Use the filters below to find and compare flights from Milwaukee to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MilwaukeeGreenville

MKE - GSP

MKEGSP

Milwaukee-Mitchell

mar. 5/5

4:30 pm-9:40 pm

1 stop4h 10m

Greenville

mié. 5/6

6:45 am-10:30 am

1 stop4h 45m

$251

MilwaukeeHilton Head Island

MKE - HHH

MKEHHH

Milwaukee-Mitchell

sáb. 5/9

10:22 am-3:33 pm

1 stop4h 11m

Hilton Head Island

sáb. 5/16

12:18 pm-4:12 pm

1 stop4h 54m

$261

MilwaukeeMyrtle Beach

MKE - MYR

MKEMYR

Milwaukee-Mitchell

mar. 4/21

6:50 am-2:17 pm

1 stop6h 27m

Myrtle Beach Intl

mar. 4/28

3:15 pm-9:49 pm

1 stop7h 34m

$263

MilwaukeeGreenville

MKE - GSP

MKEGSP

Milwaukee-Mitchell

sáb. 5/9

3:25 pm-10:58 pm

1 stop6h 33m

Greenville

mar. 5/12

6:36 am-9:45 am

1 stop4h 09m

$277

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

mar. 5/12

5:23 am-11:11 am

1 stop4h 48m

Columbia Metropolitan

sáb. 5/16

5:38 am-9:07 am

1 stop4h 29m

$283

MilwaukeeGreenville

MKE - GSP

MKEGSP

Milwaukee-Mitchell

sáb. 5/9

2:00 pm-8:40 pm

2 stops5h 40m

Greenville

mar. 5/12

1:55 pm-9:45 pm

2 stops8h 50m

$287

MilwaukeeGreenville

MKE - GSP

MKEGSP

Milwaukee-Mitchell

lun. 4/20

7:10 am-5:50 pm

2 stops9h 40m

Greenville

mié. 4/22

1:55 pm-10:35 pm

2 stops9h 40m

$295

MilwaukeeHilton Head Island

MKE - HHH

MKEHHH

Milwaukee-Mitchell

sáb. 5/2

8:11 am-6:20 pm

2 stops9h 09m

Hilton Head Island

sáb. 5/9

4:10 pm-9:23 pm

1 stop6h 13m

$309

MilwaukeeHilton Head Island

MKE - HHH

MKEHHH

Milwaukee-Mitchell

vie. 5/1

10:11 am-3:20 pm

1 stop4h 09m

Hilton Head Island

mar. 5/5

4:00 pm-9:30 pm

1 stop6h 30m

$310

MilwaukeeCharlotte

MKE - CLT

MKECLT

Milwaukee-Mitchell

sáb. 5/9

5:40 am-3:10 pm

2 stops8h 30m

Charlotte Douglas

sáb. 5/16

8:10 am-11:15 am

1 stop4h 05m

$316

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/28

Showing 1-10 of 60 resultsSorted by cheapest first
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6

Best time to book a flight from Milwaukee to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Milwaukee with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Milwaukee to South Carolina

What is the cheapest month to book a flight from Milwaukee to South Carolina?

Currently, July is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $61). Flying from Milwaukee to South Carolina in March is currently the most expensive (average of $208). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MKE to SC?

Find hourly flight availability from Milwaukee to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated marzo 29, 2026.

It’s typically best to fly out from Milwaukee to South Carolina in the evening. Doing so could potentially save you 37% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Milwaukee to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Milwaukee to South Carolina. Price data was last updated on March 30, 2025.

Travelers seeking maximum savings on their Milwaukee to South Carolina flight should consider departing on Friday evenings when fares are most often at their lowest. Saturday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Milwaukee to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated marzo 29, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Milwaukee to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,331 reviews

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,331 reviews
Southwest
8.0
Very good
4,331 reviews

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Delta
7.9
Good
8,359 reviews
Southwest
8.0
Very good
4,331 reviews

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
United Airlines
7.4
Good
9,509 reviews
Southwest
8.0
Very good
4,331 reviews

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,521 reviews
Southwest
8.0
Very good
4,331 reviews

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Spirit Airlines
6.3
Okay
8,551 reviews
Southwest
8.0
Very good
4,331 reviews

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Milwaukee to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Milwaukee to South Carolina?

    Milwaukee-Mitchell (MKE), located 6.4 mi from the city center, is the airport you fly out of when you book flights from Milwaukee to South Carolina.

  • How long is the flight from Milwaukee to South Carolina?

    Southwest, Delta, and United Airlines can get you from Milwaukee to South Carolina in just under 4h 10m. Your travel time can differ by up to 2h 17m. There are 634 mi between Milwaukee and South Carolina. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Milwaukee to South Carolina?

    While some choose either Milwaukee-Mitchell - Charleston or Milwaukee-Mitchell - Charlotte Douglas, Milwaukee-Mitchell - Savannah/Hilton Head is the most popular route from Milwaukee to South Carolina.

  • Can I find deals for flights from Milwaukee to South Carolina that include hotel bookings?

    Yes. In addition to deals on Milwaukee to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Milwaukee to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Milwaukee to South Carolina.

  • Can I find deals for business class flights from Milwaukee to South Carolina?

    Yes. Cheapflights offers flight deals from Milwaukee to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Milwaukee to South Carolina?

    Currently, July is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $61). Flying from Milwaukee to South Carolina in March is currently the most expensive (average of $208). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Milwaukee to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Milwaukee to South Carolina

Discover the top 5 airlines that operate flights from Milwaukee to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated marzo 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$127Average$357FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$193Average$198FlexibilityNo cancel feeOn-time65%
SouthwestCheapest$201Average$414FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$203Average$383FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$412FlexibilityNo cancel feeOn-time69%

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