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South Carolina

$68+ Cheap flights from Milwaukee (MKE) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/9. Fares are subject to change and may not be available on all flights or dates of travel.
MKE — CHS
Feb 7 — Feb 141
Sat 2/7
Sat 2/14
1 adult, Economy
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Cheap flight deals from Milwaukee to South Carolina

Keep the following information in mind while searching for Milwaukee to South Carolina flight deals. Data was last updated January 8, 2026.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$128
(Frontier)

One-way from

$68
(Kiwi.com)

Popular in

March

Cheapest in

November

Average price

$344
Provider with most accurate pricing for Milwaukee-Mitchell-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Milwaukee-Mitchell-Myrtle Beach Intl flights.
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From Milwaukee-Mitchell to South Carolina
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One-way flight from Milwaukee-Mitchell to South Carolina
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Highest demand for flights based on searches. 7% potential increase in price ($30 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Milwaukee to South Carolina

Cheapest flights from Milwaukee to South Carolina
Explore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 8, 2026.

This Frontier deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/317:48 pmMKE - CLT
1 stop12h 42mFrontier
Tue 2/311:35 amCLT - MKE
1 stop7h 23mFrontier
Deal found 1/6$128
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/276:53 pmMKE - CLT
1 stop21h 01mMultiple Airlines
Mon 2/27:50 pmCLT - MKE
1 stop23h 08mMultiple Airlines
Deal found 1/6$131
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/27:01 pmMKE - CLT
1 stop14h 39mFrontier
Wed 2/112:46 pmCLT - MKE
1 stop17h 54mFrontier
Deal found 1/6$135
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/27:01 pmMKE - CLT
1 stop14h 39mFrontier
Fri 2/69:59 pmCLT - MKE
1 stop13h 18mFrontier
Deal found 1/6$142
This Frontier deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:35 pmMKE - CLT
1 stop12h 28mFrontier
Sat 3/149:28 pmCLT - MKE
1 stop11h 02mFrontier
Deal found 1/7$150
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/27:01 pmMKE - CLT
1 stop14h 39mMultiple Airlines
Wed 2/117:43 pmCLT - MKE
2 stops12h 57mMultiple Airlines
Deal found 1/6$151
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/27:01 pmMKE - CLT
1 stop14h 39mFrontier
Thu 2/121:17 pmCLT - MKE
1 stop21h 26mFrontier
Deal found 1/6$159
This Kiwi.com deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/317:48 pmMKE - CLT
1 stop13h 29mMultiple Airlines
Mon 2/29:56 pmCLT - MKE
1 stop21h 02mMultiple Airlines
Deal found 1/7$164
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/317:48 pmMKE - CLT
1 stop12h 42mFrontier
Wed 2/112:46 pmCLT - MKE
1 stop17h 54mFrontier
Deal found 1/6$170
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/77:48 pmMKE - CLT
1 stop13h 29mMultiple Airlines
Wed 2/117:43 pmCLT - MKE
2 stops12h 57mMultiple Airlines
Deal found 1/6$175
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/317:48 pmMKE - CLT
2 stops24h 59mMultiple Airlines
Tue 2/311:35 amCLT - MKE
1 stop7h 23mMultiple Airlines
Deal found 1/6$178
This United Airlines deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/115:00 amMKE - GSP
1 stop4h 16mUnited Airlines
Tue 2/176:30 amGSP - MKE
1 stop5h 00mUnited Airlines
Deal found 1/8$223

Cheapflights Fare Finder

 
Customize your flight search to find flights from Milwaukee to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from Milwaukee to South Carolina that are best for you.

Fly from

Milwaukee

Fly to

South Carolina

Route

Depart

Return

Price

MilwaukeeGreenville

MKE - GSP

MKEGSP

Milwaukee-Mitchell

Wed 2/11

5:00 am-10:16 am

1 stop4h 16m

Greenville

Tue 2/17

6:30 am-10:30 am

1 stop5h 00m

$223

MilwaukeeGreenville

MKE - GSP

MKEGSP

Milwaukee-Mitchell

Wed 2/11

6:35 am-5:40 pm

2 stops10h 05m

Greenville

Tue 2/17

8:20 am-12:15 pm

1 stop4h 55m

$228

MilwaukeeMyrtle Beach

MKE - MYR

MKEMYR

Milwaukee-Mitchell

Wed 2/11

6:06 am-11:35 am

1 stop4h 29m

Myrtle Beach Intl

Wed 2/18

5:18 pm-11:38 pm

1 stop7h 20m

$237

MilwaukeeMyrtle Beach

MKE - MYR

MKEMYR

Milwaukee-Mitchell

Wed 2/25

6:40 am-12:11 pm

1 stop4h 31m

Myrtle Beach Intl

Tue 3/3

1:08 pm-4:08 pm

1 stop4h 00m

$237

MilwaukeeCharleston

MKE - CHS

MKECHS

Milwaukee-Mitchell

Wed 2/25

6:00 am-12:30 pm

1 stop5h 30m

Charleston

Tue 3/3

2:48 pm-8:55 pm

2 stops7h 07m

$242

MilwaukeeGreenville

MKE - GSP

MKEGSP

Milwaukee-Mitchell

Wed 2/18

5:03 pm-10:24 pm

1 stop4h 21m

Greenville

Thu 2/19

8:19 am-11:13 am

1 stop3h 54m

$247

MilwaukeeGreenville

MKE - GSP

MKEGSP

Milwaukee-Mitchell

Thu 1/29

11:30 am-4:52 pm

1 stop4h 22m

Greenville

Tue 2/3

6:35 am-12:09 pm

1 stop6h 34m

$247

MilwaukeeMyrtle Beach

MKE - MYR

MKEMYR

Milwaukee-Mitchell

Sat 2/7

7:48 pm-9:50 am

1 stop13h 02m

Myrtle Beach Intl

Tue 2/10

9:59 pm-7:40 am

2 stops34h 41m

$248

MilwaukeeGreenville

MKE - GSP

MKEGSP

Milwaukee-Mitchell

Wed 2/18

1:25 pm-11:59 pm

2 stops9h 34m

Greenville

Thu 2/19

6:30 am-12:35 pm

1 stop7h 05m

$252

MilwaukeeGreenville

MKE - GSP

MKEGSP

Milwaukee-Mitchell

Thu 1/29

7:30 am-5:35 pm

2 stops9h 05m

Greenville

Tue 2/3

10:05 am-7:55 pm

2 stops10h 50m

$258

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/8

Showing 1-10 of 60 results
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Best time to book a flight from Milwaukee to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Milwaukee with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Milwaukee to South Carolina

What is the cheapest month to book a flight from Milwaukee to South Carolina?

Currently, July is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $60). Flying from Milwaukee to South Carolina in December is currently the most expensive (average of $202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MKE to SC?

Find hourly flight availability from Milwaukee to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 8, 2026.

It’s typically best to fly out from Milwaukee to South Carolina in the evening. Doing so could potentially save you 37% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Milwaukee to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Milwaukee to South Carolina. Price data was last updated on March 30, 2025.

Travelers seeking maximum savings on their Milwaukee to South Carolina flight should consider departing on Friday evenings when fares are most often at their lowest. Saturday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 8, 2026.
See what other customers who have flown with Southwest, Delta, and United Airlines from Milwaukee to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Entertainment

7.5

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,248 reviews
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Entertainment

7.5

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,025 reviews
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Entertainment

7.5

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,139 reviews
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Entertainment

7.5

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,095 reviews
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Entertainment

7.5

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Spirit Airlines
6.3
Okay
8,287 reviews
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Entertainment

7.5

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Milwaukee to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Milwaukee to South Carolina?

    Milwaukee-Mitchell (MKE), located 6.4 mi from the city center, is the airport you fly out of when you book flights from Milwaukee to South Carolina.

  • How long is the flight from Milwaukee to South Carolina?

    United Airlines, Southwest, and American Airlines can get you from Milwaukee to South Carolina in just under 4h 16m. Your travel time can differ by up to 5h 49m. There are 634 mi between Milwaukee and South Carolina. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Milwaukee to South Carolina one-way?

    For one-way options, check prices for Sun Country Air. According to our data, you can fly for as low as $107. Users have also found prices from $158 and $164 on Aeromexico and Southwest, respectively.

  • What are the most popular routes from Milwaukee to South Carolina?

    While some choose either Milwaukee-Mitchell - Charlotte Douglas or Milwaukee-Mitchell - Charleston, Milwaukee-Mitchell - Myrtle Beach Intl is the most popular route from Milwaukee to South Carolina.

  • Can I find deals for flights from Milwaukee to South Carolina that include hotel bookings?

    Yes. In addition to deals on Milwaukee to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Milwaukee to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Milwaukee to South Carolina.

  • Can I find deals for business class flights from Milwaukee to South Carolina?

    Yes. Cheapflights offers flight deals from Milwaukee to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Milwaukee to South Carolina?

    Currently, July is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $60). Flying from Milwaukee to South Carolina in December is currently the most expensive (average of $202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Milwaukee to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Milwaukee to South Carolina

Discover the top 5 airlines that operate flights from Milwaukee to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$141Average$239FlexibilityNo cancel feeOn-time65%
SouthwestCheapest$201Average$402FlexibilityNo cancel feeOn-time63%
DeltaCheapest$216Average$359FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$377FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$394FlexibilityNo cancel feeOn-time69%

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