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South Carolina

$113+ Cheap flights from Knoxville (TYS) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Knoxville to South Carolina

Keep the following information in mind while searching for Knoxville to South Carolina flight deals. Data was last updated September 15, 2025.

Round-trip from

$197
(Delta)

One-way from

$113
(Kiwi.com)

Popular in

November

Cheapest in

December

Average price

$283
From Knoxville McGhee Tyson to South Carolina
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One-way flight from Knoxville McGhee Tyson to South Carolina
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Highest demand for flights based on searches. 17% potential increase in price ($74 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to South Carolina

Cheapest flights from Knoxville to South Carolina
Explore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/153:51 pmTYS - SAV
1 stop5h 07mDelta
Tue 11/185:36 amSAV - TYS
1 stop4h 01mDelta
Deal found 9/12$197
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1310:15 amTYS - CLT
1 stop13h 07mMultiple Airlines
Wed 12/179:46 pmCLT - TYS
1 stop24h 10mMultiple Airlines
Deal found 9/13$220
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1312:08 pmTYS - CLT
1 stop11h 20mMultiple Airlines
Mon 10/203:09 pmCLT - TYS
1 stop19h 24mMultiple Airlines
Deal found 9/15$228
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:06 amTYS - CLT
1 stop24h 29mAmerican Airlines
Sun 11/99:01 amCLT - TYS
Nonstop1h 18mAmerican Airlines
Deal found 9/14$229
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/312:02 pmTYS - MYR
1 stop4h 42mAmerican Airlines
Tue 11/47:30 amMYR - TYS
1 stop4h 16mAmerican Airlines
Deal found 9/12$236
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/77:43 pmTYS - CHS
1 stop3h 25mAmerican Airlines
Mon 10/137:43 pmCHS - TYS
1 stop4h 07mAmerican Airlines
Deal found 9/12$236
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/17:15 amTYS - SAV
1 stop27h 50mMultiple Airlines
Sat 10/43:15 pmSAV - TYS
2 stops29h 10mMultiple Airlines
Deal found 9/13$243
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/312:26 pmTYS - CLT
1 stop18h 58mMultiple Airlines
Sun 11/210:06 pmCLT - TYS
1 stop14h 27mMultiple Airlines
Deal found 9/14$244
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/291:22 pmTYS - CHS
1 stop19h 15mMultiple Airlines
Fri 10/310:10 amCHS - TYS
1 stop24h 08mMultiple Airlines
Deal found 9/13$245
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/255:55 pmTYS - CHS
1 stop15h 10mMultiple Airlines
Sun 9/2812:08 pmCHS - TYS
1 stop28h 29mMultiple Airlines
Deal found 9/12$247
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/154:15 pmTYS - SAV
2 stops7h 44mAmerican Airlines
Tue 11/183:05 pmSAV - TYS
1 stop3h 49mAmerican Airlines
Deal found 9/12$248
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/274:31 pmTYS - CLT
1 stop16h 51mMultiple Airlines
Sun 9/287:16 pmCLT - TYS
1 stop22h 18mMultiple Airlines
Deal found 9/13$253

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.

Fly from

Knoxville

Fly to

South Carolina

Route

Depart

Return

Price

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Sat 11/15

3:51 pm-8:58 pm

1 stop5h 07m

Savannah/Hilton Head

Tue 11/18

5:36 am-9:37 am

1 stop4h 01m

$197

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Sat 12/13

10:15 am-11:22 pm

1 stop13h 07m

Charlotte Douglas

Wed 12/17

9:46 pm-9:56 pm

1 stop24h 10m

$220

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Fri 10/31

2:02 pm-6:44 pm

1 stop4h 42m

Myrtle Beach Intl

Tue 11/4

7:30 am-11:46 am

1 stop4h 16m

$236

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Tue 10/7

7:43 pm-11:08 pm

1 stop3h 25m

Charleston

Mon 10/13

7:43 pm-11:50 pm

1 stop4h 07m

$236

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 9/29

1:22 pm-8:37 am

1 stop19h 15m

Charleston

Fri 10/3

10:10 am-10:18 am

1 stop24h 08m

$245

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 9/25

5:55 pm-9:05 am

1 stop15h 10m

Charleston

Sun 9/28

12:08 pm-4:37 pm

1 stop28h 29m

$247

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Sat 11/15

4:15 pm-11:59 pm

2 stops7h 44m

Savannah/Hilton Head

Tue 11/18

3:05 pm-6:54 pm

1 stop3h 49m

$248

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Mon 10/13

12:08 pm-11:28 pm

1 stop11h 20m

Charlotte Douglas

Mon 10/20

1:20 pm-11:16 pm

2 stops9h 56m

$249

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Sat 9/27

4:31 pm-9:22 am

1 stop16h 51m

Charlotte Douglas

Sun 9/28

7:16 pm-5:34 pm

1 stop22h 18m

$253

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Fri 11/7

9:09 pm-3:41 pm

2 stops42h 32m

Savannah/Hilton Head

Tue 11/18

2:40 pm-12:57 pm

1 stop22h 17m

$255

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 50 results
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Best time to book a flight from Knoxville to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South Carolina

What is the cheapest month to book a flight from Knoxville to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $217). Flying from Knoxville to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SC?

Find hourly flight availability from Knoxville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to South Carolina as you normally would.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 15, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,954 reviews
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,954 reviews

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South Carolina?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to South Carolina. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to South Carolina?

    Airlines like Delta, American Airlines, and Allegiant Air fly from Knoxville to South Carolina in about 5h 07m. The time it takes to get you to your destination can typically vary by up to 19h 22m. The distance between Knoxville and South Carolina is about 300 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Knoxville to South Carolina?

    The most popular route from Knoxville to South Carolina is Knoxville McGhee Tyson - Myrtle Beach Intl. You may also consider Knoxville McGhee Tyson - Charlotte Douglas or Knoxville McGhee Tyson - Savannah/Hilton Head.

  • Can I find deals for flights from Knoxville to South Carolina that include hotel bookings?

    Yes. In addition to deals on Knoxville to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South Carolina.

  • Can I find deals for business class flights from Knoxville to South Carolina?

    Yes. Cheapflights offers flight deals from Knoxville to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $217). Flying from Knoxville to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to South Carolina

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Top 2 airlines flying from Knoxville to South Carolina

Discover the top 2 airlines that operate flights from Knoxville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$208Average$371FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$459FlexibilityNo cancel feeOn-time71%

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