HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$93+ Cheap flights from Knoxville (TYS) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to South Carolina

Cheapest flights from Knoxville to South Carolina
Explore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:07 pmTYS - CHS
1 stop27h 16mMultiple Airlines
Sun 1/410:18 pmCHS - TYS
1 stop9h 45mMultiple Airlines
Deal found 12/16$288
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:07 pmTYS - CHS
1 stop27h 16mMultiple Airlines
Fri 1/210:18 pmCHS - TYS
1 stop10h 00mMultiple Airlines
Deal found 12/17$356
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:15 amTYS - SAV
1 stop28h 13mMultiple Airlines
Sun 1/411:00 amSAV - TYS
1 stop21h 33mMultiple Airlines
Deal found 12/16$357
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/199:25 pmTYS - SAV
1 stop21h 02mAllegiant Air
Sun 12/219:00 amSAV - TYS
1 stop12h 56mAllegiant Air
Deal found 12/15$358
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2411:08 amTYS - MYR
1 stop7h 00mMultiple Airlines
Thu 12/257:32 pmMYR - TYS
1 stop14h 43mMultiple Airlines
Deal found 12/16$360
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:08 amTYS - MYR
1 stop7h 00mMultiple Airlines
Sun 1/49:54 amMYR - TYS
1 stop22h 09mMultiple Airlines
Deal found 12/16$384
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:00 amTYS - CLT
1 stop7h 56mMultiple Airlines
Wed 12/319:38 pmCLT - TYS
2 stops36h 37mMultiple Airlines
Deal found 12/16$394
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/194:22 pmTYS - CLT
1 stop43h 39mAmerican Airlines
Sun 12/213:29 pmCLT - TYS
Nonstop1h 15mAmerican Airlines
Deal found 12/16$408
This Kiwi.com deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:38 pmTYS - CLT
1 stop19h 59mMultiple Airlines
Wed 12/249:04 pmCLT - TYS
2 stops18h 12mMultiple Airlines
Deal found 12/18$409
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/195:38 pmTYS - CLT
1 stop21h 23mMultiple Airlines
Sun 12/219:34 pmCLT - TYS
1 stop24h 19mMultiple Airlines
Deal found 12/16$437
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/208:53 amTYS - MYR
1 stop9h 15mMultiple Airlines
Mon 12/229:54 amMYR - TYS
1 stop22h 24mMultiple Airlines
Deal found 12/16$448
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3110:09 amTYS - CAE
1 stop5h 30mAmerican Airlines
Sun 1/47:59 pmCAE - TYS
1 stop3h 48mAmerican Airlines
Deal found 12/16$466

Find flight deals from Knoxville to South Carolina

Keep the following information in mind while searching for Knoxville to South Carolina flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$203
(Kiwi.com)

One-way from

$93
(Trip.com)

Popular in

January

Cheapest in

August

Average price

$511
Provider with most accurate pricing for Knoxville McGhee Tyson-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Myrtle Beach Intl flights.
Search Deals
From Knoxville McGhee Tyson to South Carolina
Search Deals
One-way flight from Knoxville McGhee Tyson to South Carolina
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($86 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.

Fly from

Knoxville

Fly to

South Carolina

Route

Depart

Return

Price

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Mon 2/23

12:55 pm-1:51 pm

1 stop24h 56m

Charlotte Douglas

Thu 2/26

1:17 pm-10:11 pm

1 stop8h 54m

$203

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 1/9

8:30 am-5:36 pm

1 stop9h 06m

Charleston

Sun 1/11

6:35 pm-5:28 pm

2 stops22h 53m

$225

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Thu 1/29

9:29 am-6:48 pm

1 stop9h 19m

Charlotte Douglas

Sat 1/31

9:50 pm-11:05 pm

2 stops25h 15m

$231

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Mon 2/23

7:15 am-2:17 pm

1 stop7h 02m

Charlotte Douglas

Wed 2/25

1:24 pm-2:35 pm

1 stop25h 11m

$240

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 1/22

9:29 am-5:36 pm

1 stop8h 07m

Charleston

Thu 1/29

6:35 pm-5:28 pm

2 stops22h 53m

$246

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Mon 2/23

7:22 pm-11:54 pm

2 stops28h 32m

Charlotte Douglas

Fri 2/27

8:53 am-4:59 pm

1 stop8h 06m

$252

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Sat 1/17

5:14 pm-11:27 pm

1 stop6h 13m

Columbia Metropolitan

Tue 1/20

7:10 pm-10:54 pm

1 stop3h 44m

$263

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Fri 1/9

8:30 am-11:25 pm

1 stop14h 55m

Savannah/Hilton Head

Sun 1/11

9:00 am-11:05 pm

2 stops14h 05m

$266

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Tue 3/24

3:00 pm-2:17 pm

1 stop23h 17m

Charlotte Douglas

Thu 3/26

2:37 pm-10:59 pm

1 stop8h 22m

$273

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Sat 1/3

2:23 pm-8:39 pm

2 stops30h 16m

Charlotte Douglas

Sat 1/10

7:43 pm-8:39 am

1 stop12h 56m

$285

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 59 results
1
2
3
...
6

Best time to book a flight from Knoxville to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South Carolina

What is the cheapest month to book a flight from Knoxville to South Carolina?

Currently, June is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $174). Flying from Knoxville to South Carolina in December is currently the most expensive (average of $319). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SC?

Find hourly flight availability from Knoxville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

One of the essential ways to save on airfare from Knoxville to South Carolina is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight at noon could potentially save you up to 22% on airfare.

What is the cheapest day to fly from Knoxville to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to South Carolina flight should consider departing on Monday evenings when fares are most often at their lowest. Tuesday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 18, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,005 reviews

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,005 reviews
Delta
7.9
Good
8,005 reviews

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,005 reviews

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South Carolina?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to South Carolina. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to South Carolina?

    Airlines like American Airlines, Delta, and Southwest fly from Knoxville to South Carolina in about 4h 18m. The time it takes to get you to your destination can typically vary by up to 1h 55m. The distance between Knoxville and South Carolina is about 323 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Knoxville to South Carolina one-way?

    $212 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $276 and $308, respectively.

  • What are the most popular routes from Knoxville to South Carolina?

    The most popular route from Knoxville to South Carolina is Knoxville McGhee Tyson - Charleston. You may also consider Knoxville McGhee Tyson - Savannah/Hilton Head or Knoxville McGhee Tyson - Myrtle Beach Intl.

  • Can I find deals for flights from Knoxville to South Carolina that include hotel bookings?

    Yes. In addition to deals on Knoxville to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South Carolina.

  • Can I find deals for business class flights from Knoxville to South Carolina?

    Yes. Cheapflights offers flight deals from Knoxville to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South Carolina?

    Currently, June is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $174). Flying from Knoxville to South Carolina in December is currently the most expensive (average of $319). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to John F Kennedy Intl flights
Nashville to LaGuardia flights
Nashville to Newark flights
Nashville to Dallas/Fort Worth flights
Nashville to Miami flights
Nashville to Los Angeles flights
Nashville to Fort Lauderdale flights
Nashville to Orlando flights
Nashville to Las Vegas flights
Nashville to Denver flights
Memphis to John F Kennedy Intl flights
Memphis to LaGuardia flights
Nashville to Seattle flights
Nashville to O'Hare Intl flights
Nashville to Sky Harbor Intl flights
Nashville to Dulles Intl flights
Chattanooga to LaGuardia flights
Memphis to Las Vegas flights
Memphis to Orlando flights
Nashville to Hobby flights
Memphis to Newark flights
Memphis to Denver flights
Memphis to Atlanta flights
Nashville to Reagan-National flights
Nashville to Tampa flights
Nashville to Boston flights
Memphis to Hobby flights
Memphis to Miami flights
Nashville to Sarasota flights
Memphis to Dallas/Fort Worth flights
Nashville to Baltimore flights
Nashville to Salt Lake City flights
Memphis to Los Angeles flights
Knoxville to Denver flights
Chattanooga to Orlando flights
Nashville to George Bush Intcntl flights
Chattanooga to John F Kennedy Intl flights
Knoxville to LaGuardia flights
Nashville to New Orleans flights
Nashville to San Diego flights
Nashville to San Francisco flights
Nashville to Honolulu flights
Memphis to Seattle flights
Memphis to George Bush Intcntl flights
Nashville to Ontario flights
Knoxville to Seattle flights
Nashville to Austin flights
Knoxville to John F Kennedy Intl flights
Nashville to Love Field flights
Knoxville to Dallas/Fort Worth flights

Top 2 airlines flying from Knoxville to South Carolina

Discover the top 2 airlines that operate flights from Knoxville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$396FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$384FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.