HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$108+ Cheap flights from Knoxville (TYS) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/26. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Knoxville to South Carolina

Cheapest flights from Knoxville to South Carolina
Explore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/79:20 pmTYS - CLT
1 stop15h 03mMultiple Airlines
Sun 11/99:20 pmCLT - TYS
1 stop25h 54mMultiple Airlines
Deal found 10/28$205
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/139:54 amTYS - CHS
1 stop12h 48mMultiple Airlines
Mon 11/179:02 amCHS - TYS
2 stops14h 12mMultiple Airlines
Deal found 10/28$216
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/124:32 pmTYS - CLT
1 stop16h 30mMultiple Airlines
Sun 11/169:20 pmCLT - TYS
1 stop16h 37mMultiple Airlines
Deal found 10/28$233
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/266:18 pmTYS - CLT
1 stop21h 14mMultiple Airlines
Wed 12/35:59 pmCLT - TYS
1 stop17h 54mMultiple Airlines
Deal found 10/29$234
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/109:27 pmTYS - CLT
1 stop16h 05mMultiple Airlines
Thu 11/132:45 pmCLT - TYS
1 stop8h 14mMultiple Airlines
Deal found 10/29$235
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/219:45 pmTYS - CLT
1 stop19h 05mMultiple Airlines
Mon 11/242:47 pmCLT - TYS
1 stop8h 05mMultiple Airlines
Deal found 10/28$236
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/219:35 pmTYS - CLT
1 stop10h 41mMultiple Airlines
Sun 11/237:08 pmCLT - TYS
1 stop15h 22mMultiple Airlines
Deal found 10/28$241
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/412:43 pmTYS - CHS
1 stop8h 11mMultiple Airlines
Sun 12/79:49 pmCHS - TYS
1 stop10h 44mMultiple Airlines
Deal found 10/30$241
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/198:15 amTYS - CLT
1 stop11h 43mMultiple Airlines
Fri 11/2111:56 amCLT - TYS
1 stop9h 34mMultiple Airlines
Deal found 10/28$255
This Mytrip deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/149:00 amTYS - CLT
1 stop11h 33mMultiple Airlines
Mon 11/176:44 pmCLT - TYS
1 stop15h 50mMultiple Airlines
Deal found 10/27$259
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/255:28 pmTYS - CLT
1 stop14h 48mMultiple Airlines
Fri 11/2811:56 amCLT - TYS
1 stop7h 23mMultiple Airlines
Deal found 10/28$263
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/149:00 amTYS - CHS
2 stops22h 56mMultiple Airlines
Tue 11/186:11 pmCHS - TYS
1 stop18h 46mMultiple Airlines
Deal found 10/29$267

Cheap flight deals from Knoxville to South Carolina

Keep the following information in mind while searching for Knoxville to South Carolina flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$234
(Kiwi.com)

One-way from

$108
(Kiwi.com)

Popular in

March

Cheapest in

December

Average price

$399
Provider with most accurate pricing for Knoxville McGhee Tyson-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Myrtle Beach Intl flights.
Search Deals
From Knoxville McGhee Tyson to South Carolina
Search Deals
One-way flight from Knoxville McGhee Tyson to South Carolina
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($41 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.

Fly from

Knoxville

Fly to

South Carolina

Route

Depart

Return

Price

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 11/13

9:54 am-10:42 pm

1 stop12h 48m

Charleston

Mon 11/17

9:02 am-11:14 pm

2 stops14h 12m

$216

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Wed 11/26

6:18 pm-3:32 pm

1 stop21h 14m

Charlotte Douglas

Wed 12/3

5:59 pm-11:53 am

1 stop17h 54m

$234

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Mon 11/10

9:27 pm-1:32 pm

1 stop16h 05m

Charlotte Douglas

Thu 11/13

2:45 pm-10:59 pm

1 stop8h 14m

$235

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Fri 11/21

9:35 pm-8:16 am

1 stop10h 41m

Charlotte Douglas

Sun 11/23

7:08 pm-10:30 am

1 stop15h 22m

$241

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 12/4

12:43 pm-8:54 pm

1 stop8h 11m

Charleston

Sun 12/7

9:49 pm-8:33 am

1 stop10h 44m

$241

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Wed 11/19

8:15 am-7:58 pm

1 stop11h 43m

Charlotte Douglas

Fri 11/21

11:56 am-9:30 pm

1 stop9h 34m

$255

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 11/14

9:00 am-7:56 am

2 stops22h 56m

Charleston

Tue 11/18

6:11 pm-12:57 pm

1 stop18h 46m

$267

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Thu 12/11

6:30 am-4:49 pm

1 stop10h 19m

Charlotte Douglas

Tue 12/16

2:58 pm-2:03 pm

1 stop23h 05m

$269

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Wed 11/12

6:13 pm-3:40 pm

1 stop21h 27m

Columbia Metropolitan

Sun 11/16

4:30 pm-10:59 pm

1 stop6h 29m

$272

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Fri 11/14

9:00 am-8:33 pm

1 stop11h 33m

Charlotte Douglas

Mon 11/17

2:58 pm-10:34 am

2 stops19h 36m

$284

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 51 results
1
2
3
...
6

Best time to book a flight from Knoxville to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South Carolina

What is the cheapest month to book a flight from Knoxville to South Carolina?

Currently, June is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $174). Flying from Knoxville to South Carolina in October is currently the most expensive (average of $279). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SC?

Find hourly flight availability from Knoxville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

One of the essential ways to save on airfare from Knoxville to South Carolina is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight at noon could potentially save you up to 22% on airfare.

What is the cheapest day to fly from Knoxville to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to South Carolina flight should consider departing on Monday evenings when fares are most often at their lowest. Tuesday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 30, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Overall

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South Carolina?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to South Carolina. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to South Carolina?

    Airlines like Allegiant Air, Delta, and American Airlines fly from Knoxville to South Carolina in about 4h 38m. The time it takes to get you to your destination can typically vary by up to 16h 49m. The distance between Knoxville and South Carolina is about 323 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Knoxville to South Carolina?

    The most popular route from Knoxville to South Carolina is Knoxville McGhee Tyson - Charlotte Douglas. You may also consider Knoxville McGhee Tyson - Charleston or Knoxville McGhee Tyson - Myrtle Beach Intl.

  • Can I find deals for flights from Knoxville to South Carolina that include hotel bookings?

    Yes. In addition to deals on Knoxville to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South Carolina.

  • Can I find deals for business class flights from Knoxville to South Carolina?

    Yes. Cheapflights offers flight deals from Knoxville to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South Carolina?

    Currently, June is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $174). Flying from Knoxville to South Carolina in October is currently the most expensive (average of $279). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to John F Kennedy Intl flights
Nashville to LaGuardia flights
Nashville to Newark flights
Memphis to LaGuardia flights
Nashville to Los Angeles flights
Nashville to Denver flights
Nashville to Orlando flights
Nashville to Fort Lauderdale flights
Nashville to O'Hare Intl flights
Nashville to Las Vegas flights
Nashville to Seattle flights
Memphis to John F Kennedy Intl flights
Nashville to Dallas/Fort Worth flights
Memphis to Hobby flights
Nashville to Boston flights
Nashville to Miami flights
Memphis to O'Hare Intl flights
Nashville to Sky Harbor Intl flights
Memphis to Dallas/Fort Worth flights
Memphis to Orlando flights
Nashville to Philadelphia flights
Memphis to Las Vegas flights
Memphis to Newark flights
Knoxville to LaGuardia flights
Nashville to Hobby flights
Memphis to Denver flights
Nashville to Dulles Intl flights
Memphis to Los Angeles flights
Nashville to Reagan-National flights
Memphis to George Bush Intcntl flights
Knoxville to Hobby flights
Chattanooga to LaGuardia flights
Nashville to Detroit flights
Chattanooga to John F Kennedy Intl flights
Nashville to Raleigh flights
Knoxville to John F Kennedy Intl flights
Nashville to George Bush Intcntl flights
Nashville to Baltimore flights
Knoxville to Orlando Sanford Intl flights
Nashville to Ontario flights
Nashville to Tampa flights
Nashville to Salt Lake City flights
Memphis to Atlanta flights
Nashville to Santa Ana flights
Knoxville to O'Hare Intl flights
Chattanooga to Orlando flights
Knoxville to Dallas/Fort Worth flights
Knoxville to Denver flights
Nashville to Minneapolis flights
Nashville to Austin flights

Top 2 airlines flying from Knoxville to South Carolina

Discover the top 2 airlines that operate flights from Knoxville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$218Average$399FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$223Average$446FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.