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South Carolina

$105+ Cheap flights from Knoxville (TYS) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/31. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
May 5 — May 121
Mon 5/5
Mon 5/12
1 adult, Economy
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Cheap flight deals from Knoxville to South Carolina

Keep the following information in mind while searching for Knoxville to South Carolina flight deals. Data was last updated April 30, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$192
(Mytrip)

One-way from

$105
(Mytrip)

Popular in

November

Cheapest in

December

Average price

$385
Provider with most accurate pricing for Knoxville McGhee Tyson-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Myrtle Beach Intl flights.
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From Knoxville McGhee Tyson to South Carolina
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One-way flight from Knoxville McGhee Tyson to South Carolina
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Highest demand for flights based on searches. 11% potential increase in price ($51 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($18 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Knoxville to South Carolina

Cheapest flights from Knoxville to South Carolina
Explore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2025.

This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1410:04 pmTYS - CAE
1 stop12h 28mAllegiant Air
Sun 5/182:32 pmCAE - TYS
1 stop26h 15mAllegiant Air
Deal found 4/29$192
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/215:45 amTYS - MYR
1 stop4h 23mDelta
Sun 5/255:30 pmMYR - TYS
1 stop6h 21mDelta
Deal found 4/27$214
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/174:58 pmTYS - CLT
1 stop23h 25mMultiple Airlines
Sun 6/222:26 pmCLT - TYS
1 stop26h 21mMultiple Airlines
Deal found 4/29$216
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/316:00 amTYS - CLT
1 stop24h 28mAmerican Airlines
Sun 6/19:05 amCLT - TYS
Nonstop1h 23mAmerican Airlines
Deal found 4/29$224
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/277:54 pmTYS - MYR
1 stop2h 37mAmerican Airlines
Wed 6/43:00 pmMYR - TYS
1 stop4h 14mAmerican Airlines
Deal found 4/28$229
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/129:34 pmTYS - SAV
2 stops24h 16mAllegiant Air
Thu 6/196:41 pmSAV - TYS
1 stop22h 06mAllegiant Air
Deal found 4/29$246
This Mytrip deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/113:10 pmTYS - CHS
1 stop7h 47mMultiple Airlines
Wed 6/186:00 amCHS - TYS
1 stop5h 50mMultiple Airlines
Deal found 4/28$250
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/176:00 amTYS - MYR
1 stop28h 17mMultiple Airlines
Fri 5/235:32 pmMYR - TYS
1 stop21h 06mMultiple Airlines
Deal found 4/29$263
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/246:09 pmTYS - CHS
1 stop6h 06mAmerican Airlines
Sun 5/255:07 amCHS - TYS
1 stop5h 21mAmerican Airlines
Deal found 4/28$287
This Mytrip deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/139:09 amTYS - CAE
1 stop7h 26mMultiple Airlines
Fri 6/205:30 pmCAE - TYS
1 stop14h 47mMultiple Airlines
Deal found 4/28$318
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/129:34 pmTYS - SAV
2 stops24h 16mMultiple Airlines
Thu 6/192:21 pmSAV - TYS
2 stops31h 36mMultiple Airlines
Deal found 4/29$322
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/255:45 amTYS - CHS
1 stop5h 32mDelta
Sun 6/18:03 pmCHS - TYS
1 stop3h 48mDelta
Deal found 4/27$327

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.

Fly from

Knoxville

Fly to

South Carolina

Route

Depart

Return

Price

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Wed 5/14

10:04 pm-10:32 am

1 stop12h 28m

Columbia Metropolitan

Sun 5/18

2:32 pm-4:47 pm

1 stop26h 15m

$192

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Wed 5/21

5:45 am-10:08 am

1 stop4h 23m

Myrtle Beach Intl

Sun 5/25

5:30 pm-11:51 pm

1 stop6h 21m

$214

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Tue 6/17

4:58 pm-4:23 pm

1 stop23h 25m

Charlotte Douglas

Sun 6/22

2:26 pm-4:47 pm

1 stop26h 21m

$216

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Sat 5/31

6:00 am-6:28 am

1 stop24h 28m

Charlotte Douglas

Sun 6/1

9:05 am-10:28 am

Nonstop1h 23m

$224

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Tue 5/27

7:54 pm-10:31 pm

1 stop2h 37m

Myrtle Beach Intl

Wed 6/4

3:00 pm-7:14 pm

1 stop4h 14m

$229

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Thu 6/12

9:34 pm-9:50 pm

2 stops24h 16m

Savannah/Hilton Head

Thu 6/19

6:41 pm-4:47 pm

1 stop22h 06m

$246

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 6/11

3:10 pm-10:57 pm

1 stop7h 47m

Charleston

Wed 6/18

6:00 am-11:50 am

1 stop5h 50m

$250

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Sat 5/17

6:00 am-10:17 am

1 stop28h 17m

Myrtle Beach Intl

Fri 5/23

5:32 pm-2:38 pm

1 stop21h 06m

$263

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Sat 5/24

6:09 pm-12:15 am

1 stop6h 06m

Charleston

Sun 5/25

5:07 am-10:28 am

1 stop5h 21m

$287

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Fri 6/13

9:09 am-4:35 pm

1 stop7h 26m

Columbia Metropolitan

Fri 6/20

5:30 pm-8:17 am

1 stop14h 47m

$318

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 40 results
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Best time to book a flight from Knoxville to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South Carolina

What is the cheapest month to book a flight from Knoxville to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $217). Flying from Knoxville to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SC?

Find hourly flight availability from Knoxville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 30, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to South Carolina as you normally would.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 30, 2025.
Get a feel of what it's like to fly with Delta, United Airlines and Allegiant Air from Knoxville to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,929 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,929 reviews
Delta
8.0
Very good
7,929 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,929 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Allegiant Air
7.3
Good
734 reviews
Delta
8.0
Very good
7,929 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,929 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South Carolina?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to South Carolina. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • What are the cheapest airlines to fly from Knoxville to South Carolina one-way?

    $143 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on American Airlines and Delta, with prices starting from $179 and $194, respectively.

  • What are the most popular routes from Knoxville to South Carolina?

    The most popular route from Knoxville to South Carolina is Knoxville McGhee Tyson - Charlotte Douglas. You may also consider Knoxville McGhee Tyson - Charleston or Knoxville McGhee Tyson - Myrtle Beach Intl.

  • Can I find deals for flights from Knoxville to South Carolina that include hotel bookings?

    Yes. In addition to deals on Knoxville to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South Carolina.

  • Can I find deals for business class flights from Knoxville to South Carolina?

    Yes. Cheapflights offers flight deals from Knoxville to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $217). Flying from Knoxville to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Knoxville to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Knoxville to South Carolina

Discover the top 2 airlines that operate flights from Knoxville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$218Average$374FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$225Average$511FlexibilityNo cancel feeOn-time71%

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