HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$101+ Cheap flights from Knoxville (TYS) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/27. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
ago. 4 — ago. 111
lun. 8/4
lun. 8/11
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to South Carolina

Keep the following information in mind while searching for Knoxville to South Carolina flight deals. Data was last updated julio 30, 2025.

Round-trip from

$190
(Mytrip)

One-way from

$109
(Mytrip)

Popular in

November

Cheapest in

December

Average price

$428
From Knoxville McGhee Tyson to South Carolina
Search Deals
One-way flight from Knoxville McGhee Tyson to South Carolina
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($66 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from Knoxville to South Carolina

Cheapest flights from Knoxville to South Carolina
Explore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 30, 2025.

This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/156:00 amTYS - MYR
1 stop13h 45mMultiple Airlines
dom. 8/178:36 pmMYR - TYS
1 stop13h 40mMultiple Airlines
Deal found 7/29$197
This Mytrip deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/1812:08 pmTYS - CLT
1 stop9h 51mMultiple Airlines
lun. 9/226:00 amCLT - TYS
1 stop10h 37mMultiple Airlines
Deal found 7/30$225
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/212:54 pmTYS - MYR
1 stop4h 36mAmerican Airlines
mar. 8/2610:17 amMYR - TYS
1 stop4h 58mAmerican Airlines
Deal found 7/28$229
This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/118:52 amTYS - CHS
1 stop5h 53mMultiple Airlines
vie. 8/158:17 pmCHS - TYS
1 stop13h 47mMultiple Airlines
Deal found 7/28$242
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/249:12 pmTYS - CAE
1 stop13h 32mMultiple Airlines
vie. 8/2911:39 amCAE - TYS
1 stop8h 40mMultiple Airlines
Deal found 7/29$246
This Mytrip deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/277:15 amTYS - SAV
1 stop6h 49mMultiple Airlines
mié. 9/34:49 pmSAV - TYS
2 stops18h 29mMultiple Airlines
Deal found 7/30$251
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 8/55:30 amTYS - MYR
1 stop4h 40mDelta
mar. 8/126:56 pmMYR - TYS
1 stop4h 52mDelta
Deal found 7/29$254
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/105:05 amTYS - SAV
1 stop4h 44mAmerican Airlines
mié. 9/178:15 amSAV - TYS
1 stop3h 35mAmerican Airlines
Deal found 7/30$287
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/66:14 pmTYS - CAE
1 stop5h 27mDelta
mar. 9/97:45 amCAE - TYS
1 stop5h 23mDelta
Deal found 7/28$297
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/154:00 pmTYS - SAV
1 stop4h 47mDelta
mar. 11/185:30 amSAV - TYS
1 stop5h 35mDelta
Deal found 7/29$297
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/235:45 amTYS - CHS
1 stop6h 03mDelta
dom. 9/285:10 amCHS - TYS
1 stop5h 46mDelta
Deal found 7/29$297
This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/99:00 amTYS - MYR
2 stops25h 30mAllegiant Air
jue. 8/142:31 pmMYR - TYS
1 stop7h 44mAllegiant Air
Deal found 7/28$298

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 30, 2025.
Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.

Fly from

Knoxville

Fly to

South Carolina

Route

Depart

Return

Price

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

vie. 8/15

6:00 am-7:45 pm

1 stop13h 45m

Myrtle Beach Intl

dom. 8/17

8:36 pm-10:16 am

1 stop13h 40m

$197

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

jue. 9/18

12:08 pm-9:59 pm

1 stop9h 51m

Charlotte Douglas

lun. 9/22

6:00 am-4:37 pm

1 stop10h 37m

$225

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

jue. 8/21

2:54 pm-7:30 pm

1 stop4h 36m

Myrtle Beach Intl

mar. 8/26

10:17 am-3:15 pm

1 stop4h 58m

$229

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

lun. 8/11

8:52 am-2:45 pm

1 stop5h 53m

Charleston

vie. 8/15

8:17 pm-10:04 am

1 stop13h 47m

$242

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

dom. 8/24

9:12 pm-10:44 am

1 stop13h 32m

Columbia Metropolitan

vie. 8/29

11:39 am-8:19 pm

1 stop8h 40m

$246

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

mié. 8/27

7:15 am-2:04 pm

1 stop6h 49m

Savannah/Hilton Head

mié. 9/3

4:49 pm-11:18 am

2 stops18h 29m

$251

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

mar. 8/5

5:30 am-10:10 am

1 stop4h 40m

Myrtle Beach Intl

mar. 8/12

6:56 pm-11:48 pm

1 stop4h 52m

$254

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

mié. 9/10

5:05 am-9:49 am

1 stop4h 44m

Savannah/Hilton Head

mié. 9/17

8:15 am-11:50 am

1 stop3h 35m

$287

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

sáb. 9/6

6:14 pm-11:41 pm

1 stop5h 27m

Columbia Metropolitan

mar. 9/9

7:45 am-1:08 pm

1 stop5h 23m

$297

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

sáb. 11/15

4:00 pm-8:47 pm

1 stop4h 47m

Savannah/Hilton Head

mar. 11/18

5:30 am-11:05 am

1 stop5h 35m

$297

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Showing 1-10 of 41 results
1
2
3
...
5

Best time to book a flight from Knoxville to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South Carolina

What is the cheapest month to book a flight from Knoxville to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $217). Flying from Knoxville to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SC?

Find hourly flight availability from Knoxville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 30, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to South Carolina as you normally would.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated julio 30, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Knoxville to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,896 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.2
Good
703 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South Carolina?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to South Carolina. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • What are the cheapest airlines to fly from Knoxville to South Carolina one-way?

    $119 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and Allegiant Air, with prices starting from $183 and $188, respectively.

  • What are the most popular routes from Knoxville to South Carolina?

    The most popular route from Knoxville to South Carolina is Knoxville McGhee Tyson - Myrtle Beach Intl. You may also consider Knoxville McGhee Tyson - Charleston or Knoxville McGhee Tyson - Savannah/Hilton Head.

  • Can I find deals for flights from Knoxville to South Carolina that include hotel bookings?

    Yes. In addition to deals on Knoxville to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South Carolina.

  • Can I find deals for business class flights from Knoxville to South Carolina?

    Yes. Cheapflights offers flight deals from Knoxville to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $217). Flying from Knoxville to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to LaGuardia flights
Nashville to O'Hare Intl flights
Nashville to Seattle flights
Nashville to Denver flights
Nashville to Hobby flights
Nashville to John F Kennedy Intl flights
Nashville to Boston flights
Nashville to Newark flights
Memphis to LaGuardia flights
Nashville to Las Vegas flights
Memphis to Newark flights
Nashville to Orlando flights
Memphis to Las Vegas flights
Nashville to Fort Lauderdale flights
Nashville to Miami flights
Memphis to Denver flights
Nashville to George Bush Intcntl flights
Nashville to Los Angeles flights
Memphis to O'Hare Intl flights
Memphis to Dallas/Fort Worth flights
Memphis to John F Kennedy Intl flights
Nashville to San Francisco flights
Memphis to Los Angeles flights
Chattanooga to LaGuardia flights
Knoxville to O'Hare Intl flights
Memphis to Boston flights
Nashville to Dallas/Fort Worth flights
Nashville to Sky Harbor Intl flights
Memphis to Hobby flights
Memphis to Miami flights
Nashville to Reagan-National flights
Memphis to Orlando flights
Nashville to Tampa flights
Nashville to Detroit flights
Memphis to George Bush Intcntl flights
Chattanooga to John F Kennedy Intl flights
Nashville to Salt Lake City flights
Nashville to Portland flights
Nashville to Minneapolis flights
Chattanooga to Miami flights
Chattanooga to O'Hare Intl flights
Nashville to Ontario flights
Nashville to Philadelphia flights
Nashville to Dulles Intl flights
Memphis to Dulles Intl flights
Nashville to San Diego flights
Chattanooga to Dallas/Fort Worth flights
Nashville to Midway flights
Nashville to Atlanta flights
Memphis to Baltimore flights

Top 2 airlines flying from Knoxville to South Carolina

Discover the top 2 airlines that operate flights from Knoxville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$218Average$374FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$482FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.