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South Carolina

$92+ Cheap flights from Knoxville (TYS) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Knoxville to South Carolina

Cheapest flights from Knoxville to South Carolina
Explore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:14 pm
TYS
-
CLT
1 stop20h 37m
Multiple Airlines
Tue 3/32:46 pm
CLT
-
TYS
1 stop27h 40m
Multiple Airlines
Deal found 1/26$199
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/237:40 am
TYS
-
CHS
1 stop14h 53m
Multiple Airlines
Fri 3/278:07 am
CHS
-
TYS
1 stop24h 03m
Multiple Airlines
Deal found 1/28$211
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/289:08 pm
TYS
-
CLT
1 stop11h 18m
Multiple Airlines
Tue 3/32:46 pm
CLT
-
TYS
1 stop27h 40m
Multiple Airlines
Deal found 1/28$213
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/199:32 pm
TYS
-
MYR
1 stop12h 10m
Multiple Airlines
Tue 4/217:51 pm
MYR
-
TYS
1 stop14h 45m
Multiple Airlines
Deal found 1/29$240
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/139:36 pm
TYS
-
CLT
1 stop10h 50m
Multiple Airlines
Fri 2/207:13 pm
CLT
-
TYS
1 stop17h 51m
Multiple Airlines
Deal found 1/27$243
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/139:36 pm
TYS
-
CHS
1 stop20h 04m
Multiple Airlines
Mon 2/166:35 pm
CHS
-
TYS
1 stop15h 33m
Multiple Airlines
Deal found 1/28$243
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/279:36 pm
TYS
-
MYR
1 stop10h 37m
Multiple Airlines
Mon 3/99:09 am
MYR
-
TYS
1 stop25h 01m
Multiple Airlines
Deal found 1/27$245
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/183:52 pm
TYS
-
CLT
1 stop8h 04m
Multiple Airlines
Sun 2/223:07 pm
CLT
-
TYS
1 stop27h 25m
Multiple Airlines
Deal found 1/27$249
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:35 am
TYS
-
SAV
1 stop3h 41m
Delta
Wed 3/46:44 am
SAV
-
TYS
1 stop4h 24m
Delta
Deal found 1/28$263
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/162:06 pm
TYS
-
CHS
1 stop8h 27m
Multiple Airlines
Tue 3/178:07 am
CHS
-
TYS
1 stop6h 03m
Multiple Airlines
Deal found 1/28$263
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/127:00 am
TYS
-
CHS
1 stop10h 40m
Multiple Airlines
Mon 2/166:35 pm
CHS
-
TYS
1 stop15h 33m
Multiple Airlines
Deal found 1/28$264
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/612:55 pm
TYS
-
CLT
1 stop21h 00m
Multiple Airlines
Sun 2/89:59 pm
CLT
-
TYS
1 stop19h 29m
Multiple Airlines
Deal found 1/27$267

Find flight deals from Knoxville to South Carolina

Keep the following information in mind while searching for Knoxville to South Carolina flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$199
(Kiwi.com)

One-way from

$92
(Kiwi.com)

Popular in

January

Cheapest in

August

Average price

$938
Provider with most accurate pricing for Knoxville McGhee Tyson-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Myrtle Beach Intl flights.
Search Deals
From Knoxville McGhee Tyson to South Carolina
Search Deals
One-way flight from Knoxville McGhee Tyson to South Carolina
Search Deals
Highest demand for flights based on searches. 31% potential increase in price ($189 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 13% potential price decrease ($49 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.

Fly from

Knoxville

Fly to

South Carolina

Route

Depart

Return

Price

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Tue 2/24

5:14 pm-1:51 pm

1 stop20h 37m

Charlotte Douglas

Tue 3/3

2:46 pm-6:26 pm

1 stop27h 40m

$199

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 3/23

7:40 am-10:33 pm

1 stop14h 53m

Charleston

Fri 3/27

8:07 am-8:10 am

1 stop24h 03m

$211

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Sat 2/28

9:08 pm-8:26 am

1 stop11h 18m

Charlotte Douglas

Tue 3/3

2:46 pm-6:26 pm

1 stop27h 40m

$213

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Fri 2/13

9:36 pm-8:26 am

1 stop10h 50m

Charlotte Douglas

Fri 2/20

7:13 pm-1:04 pm

1 stop17h 51m

$243

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Wed 2/18

3:52 pm-11:56 pm

1 stop8h 04m

Charlotte Douglas

Sun 2/22

3:07 pm-6:32 pm

1 stop27h 25m

$249

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Wed 2/25

5:35 am-9:16 am

1 stop3h 41m

Savannah/Hilton Head

Wed 3/4

6:44 am-11:08 am

1 stop4h 24m

$263

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Fri 2/27

9:36 pm-8:13 am

1 stop10h 37m

Myrtle Beach Intl

Mon 3/9

9:54 pm-12:51 pm

2 stops38h 57m

$266

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Wed 4/15

7:05 am-12:55 pm

1 stop5h 50m

Charlotte Douglas

Sat 4/18

10:55 am-6:30 pm

1 stop7h 35m

$267

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 4/23

3:35 pm-10:41 pm

1 stop7h 06m

Charleston

Sun 4/26

7:00 am-8:42 pm

1 stop13h 42m

$270

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Thu 2/12

7:00 am-11:56 pm

1 stop16h 56m

Charlotte Douglas

Mon 2/16

10:42 pm-10:08 am

2 stops35h 26m

$272

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

Showing 1-10 of 60 results
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Best time to book a flight from Knoxville to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South Carolina

What is the cheapest month to book a flight from Knoxville to South Carolina?

Currently, June is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $174). Flying from Knoxville to South Carolina in December is currently the most expensive (average of $329). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SC?

Find hourly flight availability from Knoxville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 29, 2026.

One of the essential ways to save on airfare from Knoxville to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 73% on airfare.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 29, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,128 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,128 reviews
Delta
7.9
Good
8,128 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,205 reviews
Delta
7.9
Good
8,128 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South Carolina?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to South Carolina. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to South Carolina?

    Airlines like Delta, American Airlines, and Southwest fly from Knoxville to South Carolina in about 3h 41m. The time it takes to get you to your destination can typically vary by up to 11h 04m. The distance between Knoxville and South Carolina is about 300 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Knoxville to South Carolina?

    The most popular route from Knoxville to South Carolina is Knoxville McGhee Tyson - Myrtle Beach Intl. You may also consider Knoxville McGhee Tyson - Charleston or Knoxville McGhee Tyson - Savannah/Hilton Head.

  • Can I find deals for flights from Knoxville to South Carolina that include hotel bookings?

    Yes. In addition to deals on Knoxville to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South Carolina.

  • Can I find deals for business class flights from Knoxville to South Carolina?

    Yes. Cheapflights offers flight deals from Knoxville to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South Carolina?

    Currently, June is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $174). Flying from Knoxville to South Carolina in December is currently the most expensive (average of $329). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Knoxville to South Carolina

Discover the top 2 airlines that operate flights from Knoxville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$125Average$390FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$198Average$381FlexibilityNo cancel feeOn-time71%

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