$91+ Cheap flights from Knoxville (TYS) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHS
Apr 27 — May 41
Round-trip
1 adult, Economy
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Cheapest flights from Knoxville to South CarolinaExplore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2026.
Explore the most affordable flight options available from Knoxville to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:20 pm
TYS
- CLT
1 stop22h 15m
Multiple Airlines
Thu 4/238:56 am
CLT
- TYS
1 stop11h 46m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$172
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:25 pm
TYS
- CLT
1 stop16h 53m
Multiple Airlines
Sun 5/38:50 am
CLT
- TYS
1 stop11h 45m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$194
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/123:48 pm
TYS
- CLT
1 stop18h 14m
Multiple Airlines
Wed 5/136:41 pm
CLT
- TYS
1 stop26h 09m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$196
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:20 pm
TYS
- CLT
1 stop24h 53m
Multiple Airlines
Thu 5/1412:50 pm
CLT
- TYS
1 stop8h 00m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/241:15 pm
TYS
- CLT
1 stop7h 22m
Multiple Airlines
Mon 4/2710:22 am
CLT
- TYS
1 stop7h 08m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/269:32 pm
TYS
- CLT
1 stop11h 38m
Multiple Airlines
Sun 5/311:00 pm
CLT
- TYS
1 stop7h 29m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:20 pm
TYS
- CLT
1 stop13h 49m
Multiple Airlines
Fri 5/19:32 pm
CLT
- TYS
1 stop20h 31m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/171:15 pm
TYS
- CLT
1 stop7h 22m
Multiple Airlines
Sun 4/199:32 pm
CLT
- TYS
1 stop19h 58m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1211:27 am
TYS
- CLT
2 stops22h 10m
Multiple Airlines
Thu 4/166:35 pm
CLT
- TYS
1 stop22h 55m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/169:32 pm
TYS
- MYR
1 stop25h 57m
Multiple Airlines
Thu 4/2311:52 am
MYR
- TYS
1 stop8h 50m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/134:25 pm
TYS
- MYR
1 stop28h 11m
Multiple Airlines
Wed 5/203:17 pm
MYR
- TYS
1 stop23h 39m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/31:02 pm
TYS
- MYR
1 stop7h 34m
Multiple Airlines
Wed 6/103:17 pm
MYR
- TYS
1 stop20h 54m
Multiple Airlines
Deal found 3/28![Multiple Airlines logo]()
$250
Best flights from Knoxville to South CarolinaDiscover carefully curated flight deals from Knoxville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 28, 2026.
Discover carefully curated flight deals from Knoxville to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 28, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:20 pm
TYS
- CLT
1 stop13h 49m
Multiple Airlines
Fri 5/19:32 pm
CLT
- TYS
1 stop20h 31m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$216
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:33 pm
TYS
- CHS
1 stop4h 26m
Delta
Wed 5/136:15 am
CHS
- TYS
1 stop4h 54m
Delta
Deal found 3/23![Delta logo]()
$264
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/182:06 pm
TYS
- HHH
1 stop4h 14m
American Airlines
Wed 4/226:39 pm
HHH
- TYS
1 stop3h 45m
American Airlines
Deal found 3/25![American Airlines logo]()
$305
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:05 am
TYS
- MYR
2 stops8h 20m
Southwest
Wed 5/207:35 am
MYR
- TYS
2 stops12h 05m
Southwest
Deal found 3/27![Southwest logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/101:15 pm
TYS
- CLT
1 stop11h 21m
Multiple Airlines
Mon 4/139:40 pm
CLT
- TYS
2 stops36h 56m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$281
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:45 am
TYS
- SAV
1 stop8h 58m
United Airlines
Mon 6/112:10 pm
SAV
- TYS
1 stop11h 44m
United Airlines
Deal found 3/27![United Airlines logo]()
$588
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/294:25 pm
TYS
- MYR
1 stop15h 46m
Multiple Airlines
Fri 5/18:31 pm
MYR
- TYS
2 stops21h 32m
Multiple Airlines
Deal found 3/26![Multiple Airlines logo]()
$299
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:30 pm
TYS
- SAV
1 stop4h 19m
Delta
Sun 9/610:20 am
SAV
- TYS
1 stop4h 47m
Delta
Deal found 3/24![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:55 pm
TYS
- CLT
1 stop3h 10m
Southwest
Wed 7/226:50 am
CLT
- TYS
1 stop5h 15m
Southwest
Deal found 3/27![Southwest logo]()
$337
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:33 pm
TYS
- MYR
1 stop4h 25m
Delta
Wed 6/107:54 pm
MYR
- TYS
1 stop4h 00m
Delta
Deal found 3/25![Delta logo]()
$340
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:40 am
TYS
- MYR
1 stop6h 45m
Southwest
Sun 7/265:50 pm
MYR
- TYS
1 stop3h 25m
Southwest
Deal found 3/27![Southwest logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/101:15 pm
TYS
- CLT
1 stop6h 33m
Multiple Airlines
Tue 4/143:55 pm
CLT
- TYS
2 stops18h 41m
Multiple Airlines
Deal found 3/26![Multiple Airlines logo]()
$332
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/27:30 am
TYS
- MYR
1 stop11h 05m
Southwest
Sat 7/410:30 am
MYR
- TYS
1 stop8h 50m
Southwest
Deal found 3/24![Southwest logo]()
$348
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/105:00 am
TYS
- CAE
1 stop3h 38m
American Airlines
Tue 4/147:22 pm
CAE
- TYS
1 stop3h 34m
American Airlines
Deal found 3/26![American Airlines logo]()
$447
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/147:10 am
TYS
- CLT
2 stops10h 25m
Southwest
Sun 8/167:10 am
CLT
- TYS
1 stop5h 15m
Southwest
Deal found 3/27![Southwest logo]()
$348
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:05 am
TYS
- MYR
2 stops13h 25m
Southwest
Thu 4/168:30 am
MYR
- TYS
2 stops11h 50m
Southwest
Deal found 3/26![Southwest logo]()
$351
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:47 pm
TYS
- CHS
1 stop27h 26m
Multiple Airlines
Fri 4/108:07 am
CHS
- TYS
1 stop27h 59m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$396
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:15 am
TYS
- MYR
1 stop7h 10m
Southwest
Fri 4/243:45 pm
MYR
- TYS
1 stop4h 35m
Southwest
Deal found 3/24![Southwest logo]()
$357
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:19 pm
TYS
- CAE
1 stop18h 51m
United Airlines
Sat 8/227:35 pm
CAE
- TYS
1 stop15h 01m
United Airlines
Deal found 3/26![United Airlines logo]()
$595
This American Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:42 am
TYS
- CLT
Nonstop1h 29m
American Airlines
Sun 7/269:15 am
CLT
- TYS
Nonstop1h 23m
American Airlines
Deal found 3/28![American Airlines logo]()
$565
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/158:15 am
TYS
- CHS
1 stop5h 20m
Southwest
Sat 4/187:35 am
CHS
- TYS
1 stop7h 45m
Southwest
Deal found 3/27![Southwest logo]()
$368
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:00 am
TYS
- CLT
2 stops16h 59m
United Airlines
Thu 5/76:00 am
CLT
- TYS
2 stops10h 54m
United Airlines
Deal found 3/24![United Airlines logo]()
$600
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2612:03 pm
TYS
- HHH
1 stop3h 17m
Delta
Wed 4/2912:08 pm
HHH
- TYS
1 stop5h 00m
Delta
Deal found 3/26![Delta logo]()
$557
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1511:40 am
TYS
- HHH
1 stop6h 29m
American Airlines
Mon 4/205:04 pm
HHH
- TYS
1 stop5h 20m
American Airlines
Deal found 3/25![American Airlines logo]()
$581
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:40 am
TYS
- CHS
1 stop5h 20m
Southwest
Tue 4/1412:00 pm
CHS
- TYS
2 stops8h 50m
Southwest
Deal found 3/26![Southwest logo]()
$375
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/175:53 pm
TYS
- CLT
2 stops24h 56m
United Airlines
Sun 4/196:00 am
CLT
- TYS
1 stop9h 09m
United Airlines
Deal found 3/24![United Airlines logo]()
$607
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/258:00 am
TYS
- CAE
1 stop6h 16m
American Airlines
Mon 4/274:12 pm
CAE
- TYS
2 stops7h 47m
American Airlines
Deal found 3/25![American Airlines logo]()
$613
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/137:00 am
TYS
- SAV
2 stops14h 30m
Southwest
Tue 6/161:25 pm
SAV
- TYS
2 stops6h 55m
Southwest
Deal found 3/27![Southwest logo]()
$389
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:00 am
TYS
- CAE
2 stops16h 59m
United Airlines
Sat 5/2310:31 am
CAE
- TYS
1 stop24h 11m
United Airlines
Deal found 3/25![United Airlines logo]()
$651
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:05 am
TYS
- CHS
2 stops10h 15m
Southwest
Sun 5/106:15 am
CHS
- TYS
1 stop5h 25m
Southwest
Deal found 3/23![Southwest logo]()
$392
Last-minute flights from Knoxville to South CarolinaDiscover last-minute flight deals from Knoxville to South Carolina. Data last updated March 28, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to South Carolina. Data last updated March 28, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:30 am
TYS
- CLT
1 stop8h 19m
Multiple Airlines
Sun 4/51:46 pm
CLT
- TYS
1 stop28h 35m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/32:06 pm
TYS
- CLT
1 stop10h 30m
Multiple Airlines
Mon 4/69:00 pm
CLT
- TYS
1 stop17h 06m
Multiple Airlines
Deal found 3/28![Multiple Airlines logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1211:27 am
TYS
- CLT
2 stops22h 10m
Multiple Airlines
Thu 4/166:35 pm
CLT
- TYS
1 stop22h 55m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/169:32 pm
TYS
- MYR
1 stop25h 57m
Multiple Airlines
Thu 4/2311:52 am
MYR
- TYS
1 stop8h 50m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/171:15 pm
TYS
- CLT
1 stop7h 22m
Multiple Airlines
Sun 4/199:32 pm
CLT
- TYS
1 stop19h 58m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:20 pm
TYS
- CLT
1 stop22h 15m
Multiple Airlines
Thu 4/238:56 am
CLT
- TYS
1 stop11h 46m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$172
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:00 am
TYS
- HHH
1 stop5h 47m
American Airlines
Tue 4/282:54 pm
HHH
- TYS
1 stop6h 32m
American Airlines
Deal found 3/24![American Airlines logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/241:15 pm
TYS
- CLT
1 stop7h 22m
Multiple Airlines
Mon 4/2710:22 am
CLT
- TYS
1 stop7h 08m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:20 pm
TYS
- CLT
1 stop13h 49m
Multiple Airlines
Fri 5/19:32 pm
CLT
- TYS
1 stop20h 31m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/241:15 pm
TYS
- CLT
1 stop7h 22m
Multiple Airlines
Sun 4/269:32 pm
CLT
- TYS
1 stop19h 58m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/269:32 pm
TYS
- CLT
1 stop11h 38m
Multiple Airlines
Sun 5/311:00 pm
CLT
- TYS
1 stop7h 29m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:25 pm
TYS
- CLT
1 stop16h 53m
Multiple Airlines
Sun 5/38:50 am
CLT
- TYS
1 stop11h 45m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$194
One-way flights from Knoxville to South CarolinaSearch for one-way flight options from Knoxville to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 28, 2026.
Search for one-way flight options from Knoxville to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 28, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:25 pm
TYS
- CAE
1 stop20h 27m
Allegiant Air
Deal found 3/24![Allegiant Air logo]()
$91
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/239:32 pm
TYS
- CLT
1 stop11h 38m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$93
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/271:15 pm
TYS
- CLT
1 stop7h 22m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$94
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2512:56 pm
TYS
- CLT
1 stop7h 53m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/224:25 pm
TYS
- CLT
1 stop16h 45m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/169:32 pm
TYS
- SAV
1 stop25h 16m
Allegiant Air
Deal found 3/24![Allegiant Air logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/239:32 pm
TYS
- SAV
1 stop25h 16m
Allegiant Air
Deal found 3/25![Allegiant Air logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/199:32 pm
TYS
- CAE
1 stop20h 20m
Allegiant Air
Deal found 3/28![Allegiant Air logo]()
$111
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:00 am
TYS
- SAV
1 stop3h 34m
American Airlines
Deal found 3/24![American Airlines logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/283:46 pm
TYS
- CLT
1 stop20h 17m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$111
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:00 am
TYS
- CHS
1 stop4h 52m
American Airlines
Deal found 3/25![American Airlines logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/218:00 am
TYS
- CLT
1 stop27h 30m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$114
Find flight deals from Knoxville to South Carolina
Keep the following information in mind while searching for Knoxville to South Carolina flight deals. Data was last updated March 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $172 (Kiwi.com) |
One-way from | $91 (Kiwi.com) |
Popular in | December |
Cheapest in | August |
Average price | $477 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2026.
Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleCharlotte
TYS - CLT
TYSCLT
Knoxville McGhee Tyson
Fri 4/24
6:20 pm-8:09 am
1 stop13h 49m
Charlotte Douglas
Fri 5/1
9:32 pm-6:03 pm
1 stop20h 31m
$216
KnoxvilleCharleston
TYS - CHS
TYSCHS
Knoxville McGhee Tyson
Fri 5/8
7:33 pm-11:59 pm
1 stop4h 26m
Charleston
Wed 5/13
6:15 am-11:09 am
1 stop4h 54m
$264
KnoxvilleCharlotte
TYS - CLT
TYSCLT
Knoxville McGhee Tyson
Fri 4/10
1:15 pm-12:36 am
1 stop11h 21m
Charlotte Douglas
Mon 4/13
9:40 pm-10:36 am
2 stops36h 56m
$281
KnoxvilleMyrtle Beach
TYS - MYR
TYSMYR
Knoxville McGhee Tyson
Wed 4/29
4:25 pm-8:11 am
1 stop15h 46m
Myrtle Beach Intl
Fri 5/1
8:31 pm-6:03 pm
2 stops21h 32m
$299
KnoxvilleHilton Head Island
TYS - HHH
TYSHHH
Knoxville McGhee Tyson
Sat 4/18
2:06 pm-6:20 pm
1 stop4h 14m
Hilton Head Island
Wed 4/22
6:39 pm-10:24 pm
1 stop3h 45m
$305
KnoxvilleMyrtle Beach
TYS - MYR
TYSMYR
Knoxville McGhee Tyson
Wed 5/13
7:05 am-3:25 pm
2 stops8h 20m
Myrtle Beach Intl
Wed 5/20
7:35 am-7:40 pm
2 stops12h 05m
$315
KnoxvilleCharlotte
TYS - CLT
TYSCLT
Knoxville McGhee Tyson
Fri 4/10
1:15 pm-7:48 pm
1 stop6h 33m
Charlotte Douglas
Tue 4/14
3:55 pm-10:36 am
2 stops18h 41m
$332
KnoxvilleSavannah
TYS - SAV
TYSSAV
Knoxville McGhee Tyson
Thu 9/3
2:30 pm-6:49 pm
1 stop4h 19m
Savannah/Hilton Head
Sun 9/6
10:20 am-3:07 pm
1 stop4h 47m
$337
KnoxvilleCharlotte
TYS - CLT
TYSCLT
Knoxville McGhee Tyson
Tue 7/21
6:55 pm-10:05 pm
1 stop3h 10m
Charlotte Douglas
Wed 7/22
6:50 am-12:05 pm
1 stop5h 15m
$337
KnoxvilleMyrtle Beach
TYS - MYR
TYSMYR
Knoxville McGhee Tyson
Wed 6/3
7:33 pm-11:58 pm
1 stop4h 25m
Myrtle Beach Intl
Wed 6/10
7:54 pm-11:54 pm
1 stop4h 00m
$340
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Knoxville to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Knoxville with our price prediction graph.
TYS-CLT
TYS-MYR
TYS-HHH
TYS-CAE
TYS-SAV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to South Carolina
TYS-USSC
TYS-CLT
TYS-MYR
TYS-HHH
TYS-CAE
What is the cheapest month to book a flight from Knoxville to South Carolina?
Currently, June is the cheapest month in which you can book a flight from Knoxville to South Carolina (average of $168). Flying from Knoxville to South Carolina in December is currently the most expensive (average of $329). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from TYS to SC?
Find hourly flight availability from Knoxville to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 28, 2026.
One of the essential ways to save on airfare from Knoxville to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 73% on airfare.
How much does it cost to fly round-trip from Knoxville to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 28, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Food
7.2
Boarding
8.1
Crew
8.5
Overall
7.9
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Food
7.2
Boarding
8.1
Crew
8.5
Overall
7.9
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Food
7.2
Boarding
8.1
Crew
8.5
Overall
7.9
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Knoxville to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and South Carolina flights
Browse other Knoxville and South Carolina flight options. Last updated on March 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Knoxville to South Carolina flights
Consider these flights traveling from Knoxville to South Carolina.
Top 2 airlines flying from Knoxville to South Carolina
Discover the top 2 airlines that operate flights from Knoxville to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$125 | Average$457 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$228 | Average$399 | FlexibilityNo cancel fee | On-time71% |