How long is the flight from Columbia, Missouri to South Carolina?

Departing from Columbia, Missouri to South Carolina will take you 4h 34m. There are 669 mi between Columbia, Missouri and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

What are the most popular routes from Columbia, Missouri to South Carolina?

When deciding which route to take from Columbia, Missouri to South Carolina consider Columbia Regional - Charleston, Columbia Regional - Charlotte Douglas or Columbia Regional - Myrtle Beach Intl as they are the most popular.

What is the cheapest time of day to fly from COU to SC?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Columbia, Missouri to South Carolina as you normally would.

What airport do you fly from for flights from Columbia to South Carolina?

Columbia Regional (COU), located 11.1 mi from the city center, is the airport you fly out of when you book flights from Columbia to South Carolina.

Can I find deals for flights from Columbia to South Carolina that include hotel bookings?

Yes. In addition to deals on Columbia to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Columbia to South Carolina?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to South Carolina.

Can I find deals for business class flights from Columbia to South Carolina?

Yes. Cheapflights offers flight deals from Columbia to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$293+ Flights from Columbia, MO to South Carolina

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Cheap flight deals from Columbia to South Carolina

Cheapest flights from Columbia to South Carolina
Explore the most affordable flight options available from Columbia to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Wed 12/3110:09 amCOU - CLT

1 stop8h 01mAmerican Airlines

Sun 1/410:41 pmCLT - COU

1 stop11h 58mAmerican Airlines

Deal found 12/16

$486

Wed 12/313:10 pmCOU - CLT

2 stops7h 49mUnited Airlines

Sun 1/411:02 amCLT - COU

1 stop7h 23mUnited Airlines

Deal found 12/16

$501

Tue 12/303:20 pmCOU - MYR

2 stops7h 35mAmerican Airlines

Sat 1/35:11 amMYR - COU

2 stops7h 28mAmerican Airlines

Deal found 12/15

$624

Best flights from Columbia to South Carolina
Discover carefully curated flight deals from Columbia to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 18, 2025.

Sat 2/218:00 amCOU - CHS

1 stop4h 52mUnited Airlines

Sat 2/286:00 amCHS - COU

1 stop5h 33mUnited Airlines

Deal found 12/16

$293

Wed 5/65:57 amCOU - CLT

1 stop4h 34mAmerican Airlines

Wed 5/209:20 amCLT - COU

1 stop6h 18mAmerican Airlines

Deal found 12/15

$374

Sat 1/318:09 amCOU - CHS

1 stop4h 53mUnited Airlines

Wed 2/44:41 pmCHS - COU

1 stop5h 56mUnited Airlines

Deal found 12/14

$328

Wed 5/63:16 pmCOU - CLT

1 stop5h 07mUnited Airlines

Wed 5/2010:30 amCLT - COU

1 stop4h 59mUnited Airlines

Deal found 12/15

$330

Mon 1/2611:17 amCOU - CHS

1 stop7h 45mUnited Airlines

Sun 2/16:05 amCHS - COU

1 stop5h 37mUnited Airlines

Deal found 12/15

$363

Thu 1/17:35 amCOU - MYR

2 stops9h 41mAmerican Airlines

Mon 1/55:13 pmMYR - COU

1 stop6h 19mAmerican Airlines

Deal found 12/17

$520

Wed 3/2511:15 amCOU - CLT

1 stop5h 07mUnited Airlines

Sat 3/286:15 amCLT - COU

1 stop5h 18mUnited Airlines

Deal found 12/15

$400

Sat 4/43:16 pmCOU - CLT

1 stop5h 07mUnited Airlines

Tue 4/75:28 pmCLT - COU

1 stop4h 42mUnited Airlines

Deal found 12/14

$400

Tue 12/303:20 pmCOU - MYR

2 stops7h 35mAmerican Airlines

Sat 1/35:13 pmMYR - COU

1 stop6h 19mAmerican Airlines

Deal found 12/15

$734

Wed 1/283:10 pmCOU - MYR

2 stops20h 31mUnited Airlines

Sat 1/311:13 pmMYR - COU

2 stops33h 24mUnited Airlines

Deal found 12/14

$635

Last-minute flights from Columbia to South Carolina
Discover last-minute flight deals from Columbia to South Carolina. Data last updated December 18, 2025 and is based on user searches.

Tue 12/303:20 pmCOU - MYR

2 stops7h 35mAmerican Airlines

Sat 1/35:11 amMYR - COU

2 stops7h 28mAmerican Airlines

Deal found 12/15

$624

Wed 12/3110:09 amCOU - CLT

1 stop8h 01mAmerican Airlines

Sun 1/410:41 pmCLT - COU

1 stop11h 58mAmerican Airlines

Deal found 12/16

$486

Wed 12/313:10 pmCOU - CLT

2 stops7h 49mUnited Airlines

Sun 1/411:02 amCLT - COU

1 stop7h 23mUnited Airlines

Deal found 12/16

$501

Thu 1/13:10 pmCOU - CLT

1 stop5h 10mUnited Airlines

Mon 1/56:00 amCLT - COU

2 stops16h 19mUnited Airlines

Deal found 12/17

$499

Thu 1/17:35 amCOU - MYR

2 stops9h 41mAmerican Airlines

Mon 1/55:13 pmMYR - COU

1 stop6h 19mAmerican Airlines

Deal found 12/17

$520

Fri 1/168:09 amCOU - CLT

1 stop25h 24mUnited Airlines

Mon 1/195:35 pmCLT - COU

1 stop18h 07mUnited Airlines

Deal found 12/16

$456

Mon 1/2611:17 amCOU - CHS

1 stop7h 45mUnited Airlines

Sun 2/16:05 amCHS - COU

1 stop5h 37mUnited Airlines

Deal found 12/17

$363

Mon 1/268:09 amCOU - CHS

1 stop4h 53mUnited Airlines

Thu 1/296:05 amCHS - COU

1 stop5h 37mUnited Airlines

Deal found 12/17

$556

Wed 1/283:10 pmCOU - MYR

2 stops20h 31mUnited Airlines

Sat 1/311:13 pmMYR - COU

2 stops33h 24mUnited Airlines

Deal found 12/14

$635

Sat 1/318:09 amCOU - CHS

1 stop4h 53mUnited Airlines

Wed 2/410:15 amCHS - COU

1 stop5h 20mUnited Airlines

Deal found 12/16

$328

One-way flights from Columbia to South Carolina
Search for one-way flight options from Columbia to South Carolina. Find affordable one-way fares based on user searches. Data last updated December 18, 2025.

Sun 1/48:05 amCOU - CHS

1 stop5h 04mUnited Airlines

Deal found 12/15

$326

Wed 3/256:00 amCOU - CHS

1 stop16h 09mAmerican Airlines

Deal found 12/16

$393

Find flight deals from Columbia to South Carolina

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$293 (United Airlines)

Provider with most accurate pricing for Columbia Regional-Myrtle Beach Intl flight deals.

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From Columbia Regional to South Carolina

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Cheapflights Fare Finder

Use the filters below to find and compare flights from Columbia to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Sat 2/21

8:00 am-1:52 pm

1 stop4h 52m

Charleston

Sat 2/28

6:00 am-10:33 am

1 stop5h 33m

$293

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Sat 1/31

8:09 am-2:02 pm

1 stop4h 53m

Charleston

Wed 2/4

4:41 pm-9:37 pm

1 stop5h 56m

$328

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Wed 5/6

3:16 pm-9:23 pm

1 stop5h 07m

Charlotte Douglas

Wed 5/20

10:30 am-2:29 pm

1 stop4h 59m

$330

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Mon 1/26

11:17 am-8:02 pm

1 stop7h 45m

Charleston

Sun 2/1

6:05 am-10:42 am

1 stop5h 37m

$363

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Wed 5/6

5:57 am-11:31 am

1 stop4h 34m

Charlotte Douglas

Wed 5/20

9:20 am-2:38 pm

1 stop6h 18m

$374

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Wed 3/25

11:15 am-5:22 pm

1 stop5h 07m

Charlotte Douglas

Sat 3/28

6:15 am-10:33 am

1 stop5h 18m

$400

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Sat 4/4

3:16 pm-9:23 pm

1 stop5h 07m

Charlotte Douglas

Tue 4/7

5:28 pm-9:10 pm

1 stop4h 42m

$400

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Thu 1/1

7:35 am-6:16 pm

2 stops9h 41m

Myrtle Beach Intl

Mon 1/5

5:13 pm-10:32 pm

1 stop6h 19m

$520

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Wed 1/28

3:10 pm-12:41 pm

2 stops20h 31m

Myrtle Beach Intl

Sat 1/31

1:13 pm-9:37 pm

2 stops33h 24m

$635

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Tue 12/30

3:20 pm-11:55 pm

2 stops7h 35m

Myrtle Beach Intl

Sat 1/3

5:13 pm-10:32 pm

1 stop6h 19m

$734

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Showing 1-10 of 12 results

Best time to book a flight from Columbia to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Columbia with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbia to South Carolina

No data available for this route at this time. Please check back soon.

Reviews of airlines servicing South Carolina

See what other customers who have flown with American Airlines from Columbia to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.2

Good

11,055 reviews

Reviews

1 / 20

10.0

Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

American Airlines

7.2

Good

11,055 reviews

American Airlines

7.2

Good

11,055 reviews

Reviews

1 / 20

10.0

Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

What airport do you fly from for flights from Columbia to South Carolina?
Columbia Regional (COU), located 11.1 mi from the city center, is the airport you fly out of when you book flights from Columbia to South Carolina.
How long is the flight from Columbia, Missouri to South Carolina?
Departing from Columbia, Missouri to South Carolina will take you 4h 34m. There are 669 mi between Columbia, Missouri and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the most popular routes from Columbia, Missouri to South Carolina?
When deciding which route to take from Columbia, Missouri to South Carolina consider Columbia Regional - Charleston, Columbia Regional - Charlotte Douglas or Columbia Regional - Myrtle Beach Intl as they are the most popular.
Can I find deals for flights from Columbia to South Carolina that include hotel bookings?
Yes. In addition to deals on Columbia to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Columbia to South Carolina?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to South Carolina.
Can I find deals for business class flights from Columbia to South Carolina?
Yes. Cheapflights offers flight deals from Columbia to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

South Carolina car rentals

Charleston Airport car rentals

Myrtle Beach Intl Airport car rentals

Greenville Airport car rentals

Columbia Metropolitan Airport car rentals

Hilton Head Island Airport car rentals

Florence Airport car rentals

Myrtle Beach car rentals

Columbia car rentals

Charleston car rentals

Greenville car rentals

Florence car rentals

Top airline flying from Columbia to South Carolina

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$410	Average$488	FlexibilityNo cancel fee	On-time71%

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$293+ Cheap flights from Columbia, MO (COU) to South Carolina

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Columbia to South Carolina with Cheapflights

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Cheap flight deals from Columbia to South Carolina

Cheapest flights from Columbia to South CarolinaExplore the most affordable flight options available from Columbia to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Explore the most affordable flight options available from Columbia to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Find flight deals from Columbia to South Carolina

Keep the following information in mind while searching for Columbia to South Carolina flight deals. Data was last updated December 18, 2025.

Most accurate provider

Most trusted provider

Round-trip from

Cheapflights Fare Finder

Use the filters below to find and compare flights from Columbia to South Carolina that are best for you.

Best time to book a flight from Columbia to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Columbia with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Columbia to South Carolina

Reviews of airlines servicing South Carolina

See what other customers who have flown with American Airlines from Columbia to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Columbia to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from Columbia to South Carolina?

How long is the flight from Columbia, Missouri to South Carolina?

What are the most popular routes from Columbia, Missouri to South Carolina?

Can I find deals for flights from Columbia to South Carolina that include hotel bookings?

How can I find direct flights from Columbia to South Carolina?

Can I find deals for business class flights from Columbia to South Carolina?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Columbia to South Carolina

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Top airline flying from Columbia to South Carolina

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Cheapest flights from Columbia to South Carolina
Explore the most affordable flight options available from Columbia to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.