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South Carolina

$268+ Cheap flights from Columbia, MO (COU) to South Carolina

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/23. Fares are subject to change and may not be available on all flights or dates of travel.
COU — CHS
Feb 7 — Feb 141
Sat 2/7
Sat 2/14
1 adult, Economy
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Cheap flight deals from Columbia to South Carolina

Keep the following information in mind while searching for Columbia to South Carolina flight deals. Data was last updated January 8, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$268
(United Airlines)
Provider with most accurate pricing for Columbia Regional-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Columbia Regional-Myrtle Beach Intl flights.
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From Columbia Regional to South Carolina
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Find flight deals from Columbia to South Carolina

Cheapest flights from Columbia to South Carolina
Explore the most affordable flight options available from Columbia to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 8, 2026.

This United Airlines deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/2311:17 amCOU - CHS
1 stop7h 45mUnited Airlines
Tue 1/2710:15 amCHS - COU
1 stop5h 20mUnited Airlines
Deal found 1/8$268
This United Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/2711:17 amCOU - CHS
1 stop7h 45mUnited Airlines
Sat 1/3110:30 amCHS - COU
1 stop5h 05mUnited Airlines
Deal found 1/6$328
This United Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/268:09 amCOU - CHS
1 stop4h 53mUnited Airlines
Sun 2/16:05 amCHS - COU
1 stop5h 37mUnited Airlines
Deal found 1/7$333
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/277:00 amCOU - CLT
Nonstop2h 15mAmerican Airlines
Tue 7/79:22 pmCLT - COU
Nonstop2h 15mAmerican Airlines
Deal found 1/6$353
This United Airlines deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/73:16 pmCOU - CHS
1 stop4h 48mUnited Airlines
Tue 11/105:15 pmCHS - COU
1 stop4h 55mUnited Airlines
Deal found 1/8$363
This American Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:00 amCOU - CLT
Nonstop2h 15mAmerican Airlines
Tue 9/89:20 pmCLT - COU
Nonstop2h 15mAmerican Airlines
Deal found 1/7$368
This United Airlines deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/43:16 pmCOU - CHS
1 stop4h 48mUnited Airlines
Wed 11/1111:55 amCHS - COU
2 stops9h 35mUnited Airlines
Deal found 1/8$369
This United Airlines deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/39:00 amCOU - CHS
2 stops13h 19mUnited Airlines
Wed 11/1111:55 amCHS - COU
2 stops9h 35mUnited Airlines
Deal found 1/8$374
This United Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/2511:17 amCOU - CHS
2 stops11h 27mUnited Airlines
Sun 2/16:00 amCHS - COU
2 stops9h 35mUnited Airlines
Deal found 1/7$379
This American Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/307:00 amCOU - CLT
Nonstop2h 15mAmerican Airlines
Mon 8/39:22 pmCLT - COU
Nonstop2h 15mAmerican Airlines
Deal found 1/5$383
This United Airlines deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/13:16 pmCOU - CLT
1 stop5h 07mUnited Airlines
Sun 7/55:28 pmCLT - COU
1 stop4h 42mUnited Airlines
Deal found 1/8$387
This American Airlines deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/17:00 amCOU - CLT
Nonstop2h 15mAmerican Airlines
Sun 7/59:22 pmCLT - COU
Nonstop2h 15mAmerican Airlines
Deal found 1/8$418

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from Columbia to South Carolina that are best for you.

Fly from

Columbia

Fly to

South Carolina

Route

Depart

Return

Price

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Fri 1/23

11:17 am-8:02 pm

1 stop7h 45m

Charleston

Tue 1/27

10:15 am-2:35 pm

1 stop5h 20m

$268

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Mon 1/26

11:17 am-8:02 pm

1 stop7h 45m

Charleston

Sun 2/1

6:05 am-10:42 am

1 stop5h 37m

$333

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Sun 1/25

8:09 am-2:02 pm

1 stop4h 53m

Charleston

Sun 2/1

6:05 am-10:42 am

1 stop5h 37m

$333

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Tue 1/27

8:09 am-7:04 pm

2 stops9h 55m

Charleston

Sat 1/31

10:30 am-2:35 pm

1 stop5h 05m

$334

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Sat 6/27

6:00 am-12:04 pm

1 stop5h 04m

Charlotte Douglas

Tue 7/7

9:22 pm-10:37 pm

Nonstop2h 15m

$363

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Wed 7/1

3:16 pm-9:23 pm

1 stop5h 07m

Charlotte Douglas

Sun 7/5

6:00 am-2:29 pm

2 stops9h 29m

$393

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Wed 7/1

7:00 am-10:15 am

Nonstop2h 15m

Charlotte Douglas

Sun 7/5

9:22 pm-10:37 pm

Nonstop2h 15m

$418

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Wed 3/25

6:00 am-6:21 pm

1 stop11h 21m

Charlotte Douglas

Sat 3/28

7:48 am-6:20 pm

1 stop11h 32m

$425

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Tue 2/3

11:17 am-9:30 pm

1 stop9h 13m

Charlotte Douglas

Sat 2/7

10:44 am-2:35 pm

1 stop4h 51m

$435

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Sat 6/27

10:40 am-7:54 pm

2 stops8h 14m

Myrtle Beach Intl

Sat 7/4

4:35 pm-10:25 pm

1 stop6h 50m

$446

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/7

Showing 1-10 of 26 results
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Best time to book a flight from Columbia to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbia to South Carolina
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 8, 2026.
See what other customers who have flown with American Airlines from Columbia to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,094 reviews

Boarding

7.5

Comfort

7.2

Food

6.4

Crew

8.0

Entertainment

6.9

Overall

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,094 reviews
American Airlines
7.2
Good
11,094 reviews

Boarding

7.5

Comfort

7.2

Food

6.4

Crew

8.0

Entertainment

6.9

Overall

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from Columbia to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Columbia to South Carolina?

    Columbia Regional (COU), located 11.1 mi from the city center, is the airport you fly out of when you book flights from Columbia to South Carolina.

  • How long is the flight from Columbia, Missouri to South Carolina?

    Departing from Columbia, Missouri to South Carolina will take you 5h 04m. There are 669 mi between Columbia, Missouri and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Columbia, Missouri to South Carolina?

    When deciding which route to take from Columbia, Missouri to South Carolina consider Columbia Regional - Charlotte Douglas, Columbia Regional - Charleston or Columbia Regional - Myrtle Beach Intl as they are the most popular.

  • Can I find deals for flights from Columbia to South Carolina that include hotel bookings?

    Yes. In addition to deals on Columbia to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to South Carolina.

  • Can I find deals for business class flights from Columbia to South Carolina?

    Yes. Cheapflights offers flight deals from Columbia to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Columbia to South Carolina

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Top airline flying from Columbia to South Carolina

Discover the top airline that operate flights from Columbia to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$410Average$488FlexibilityNo cancel feeOn-time71%

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