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$308+ Cheap flights from Columbia, MO (COU) to South Carolina

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/26. Fares are subject to change and may not be available on all flights or dates of travel.
COU — CHS
Dec 26 — Jan 21
Fri 12/26
Fri 1/2
1 adult, Economy
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Cheap flight deals from Columbia to South Carolina

Keep the following information in mind while searching for Columbia to South Carolina flight deals. Data was last updated November 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$308
(United Airlines)
Provider with most accurate pricing for Columbia Regional-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Columbia Regional-Myrtle Beach Intl flights.
Search Deals
From Columbia Regional to South Carolina
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Find flight deals from Columbia to South Carolina

Cheapest flights from Columbia to South Carolina
Explore the most affordable flight options available from Columbia to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

This American Airlines deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/233:20 pmCOU - CLT
1 stop7h 26mAmerican Airlines
Tue 12/306:00 pmCLT - COU
1 stop4h 59mAmerican Airlines
Deal found 11/26$374
This United Airlines deal was found by Cheapflights users on 11/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/233:10 pmCOU - CLT
1 stop5h 10mUnited Airlines
Tue 12/306:00 amCLT - COU
2 stops9h 35mUnited Airlines
Deal found 11/26$380
This United Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/293:10 pmCOU - CLT
1 stop5h 10mUnited Airlines
Wed 1/285:35 pmCLT - COU
1 stop5h 02mUnited Airlines
Deal found 11/24$400
This American Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/911:59 amCOU - CLT
1 stop5h 52mAmerican Airlines
Sat 12/137:53 amCLT - COU
1 stop6h 32mAmerican Airlines
Deal found 11/24$418
This United Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/98:00 amCOU - CLT
2 stops12h 59mUnited Airlines
Sat 12/135:28 pmCLT - COU
1 stop4h 54mUnited Airlines
Deal found 11/24$424
This American Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:35 amCOU - CLT
2 stops6h 39mAmerican Airlines
Wed 1/287:30 amCLT - COU
2 stops8h 18mAmerican Airlines
Deal found 11/24$455
This American Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:05 pmCOU - CLT
1 stop5h 10mAmerican Airlines
Wed 1/283:44 pmCLT - COU
1 stop8h 07mAmerican Airlines
Deal found 11/24$470
This United Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/273:10 pmCOU - CLT
1 stop5h 10mUnited Airlines
Wed 1/2810:44 amCLT - COU
1 stop4h 51mUnited Airlines
Deal found 11/24$485
This American Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/97:11 amCOU - MYR
1 stop8h 28mAmerican Airlines
Sat 12/135:43 pmMYR - COU
1 stop5h 52mAmerican Airlines
Deal found 11/24$540
This American Airlines deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/107:11 amCOU - MYR
1 stop8h 28mAmerican Airlines
Sun 12/145:18 pmMYR - COU
1 stop6h 12mAmerican Airlines
Deal found 11/25$544

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
Use the filters below to find and compare flights from Columbia to South Carolina that are best for you.

Fly from

Columbia

Fly to

South Carolina

Route

Depart

Return

Price

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Mon 1/26

8:09 am-2:02 pm

1 stop4h 53m

Charleston

Sun 2/1

6:05 am-10:42 am

1 stop5h 37m

$308

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Sat 1/24

8:09 am-2:02 pm

1 stop4h 53m

Charleston

Wed 1/28

10:15 am-2:35 pm

1 stop5h 20m

$308

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Tue 12/23

3:20 pm-11:46 pm

1 stop7h 26m

Charlotte Douglas

Tue 12/30

6:00 pm-9:59 pm

1 stop4h 59m

$374

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Tue 12/23

3:10 pm-9:20 pm

1 stop5h 10m

Charlotte Douglas

Tue 12/30

6:00 am-2:35 pm

2 stops9h 35m

$380

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Sat 2/14

12:27 pm-8:34 pm

1 stop7h 07m

Charlotte Douglas

Wed 2/18

1:45 pm-6:08 pm

1 stop5h 23m

$400

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Tue 12/30

10:09 am-4:56 pm

1 stop5h 47m

Charlotte Douglas

Wed 1/28

4:42 pm-9:10 pm

1 stop5h 28m

$400

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Mon 12/29

3:10 pm-9:20 pm

1 stop5h 10m

Charlotte Douglas

Wed 1/28

5:35 pm-9:37 pm

1 stop5h 02m

$400

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Thu 1/1

6:05 pm-12:15 am

1 stop5h 10m

Charlotte Douglas

Wed 1/28

5:23 am-12:19 pm

1 stop7h 56m

$400

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Wed 12/31

10:09 am-4:56 pm

1 stop5h 47m

Charlotte Douglas

Wed 1/28

2:28 pm-9:10 pm

1 stop7h 42m

$400

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Tue 1/27

6:00 am-4:59 pm

2 stops9h 59m

Myrtle Beach Intl

Sat 1/31

5:44 pm-10:51 pm

1 stop6h 07m

$486

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/24

Showing 1-10 of 16 results
1
2

Best time to book a flight from Columbia to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbia to South Carolina
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 26, 2025.
See what other customers who have flown with American Airlines from Columbia to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,038 reviews

Crew

8.0

Overall

7.2

Boarding

7.5

Comfort

7.2

Food

6.4

Entertainment

6.9

Reviews

1 / 20
8.0
Excellent

Monica,Nov 2025

JAC - DFW

At least there was an option of entertainment on this flight.
American Airlines
7.2
Good
11,038 reviews
American Airlines
7.2
Good
11,038 reviews

Crew

8.0

Overall

7.2

Boarding

7.5

Comfort

7.2

Food

6.4

Entertainment

6.9

Reviews

1 / 20
8.0
Excellent

Monica,Nov 2025

JAC - DFW

At least there was an option of entertainment on this flight.

Related info for your journey

Find useful and relevant information for your journey from Columbia to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Columbia to South Carolina?

    Columbia Regional (COU), located 11.1 mi from the city center, is the airport you fly out of when you book flights from Columbia to South Carolina.

  • How long is the flight from Columbia, Missouri to South Carolina?

    Departing from Columbia, Missouri to South Carolina will take you 4h 53m. There are 794 mi between Columbia, Missouri and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Columbia, Missouri to South Carolina?

    When deciding which route to take from Columbia, Missouri to South Carolina consider Columbia Regional - Charlotte Douglas, Columbia Regional - Charleston or Columbia Regional - Myrtle Beach Intl as they are the most popular.

  • Can I find deals for flights from Columbia to South Carolina that include hotel bookings?

    Yes. In addition to deals on Columbia to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to South Carolina.

  • Can I find deals for business class flights from Columbia to South Carolina?

    Yes. Cheapflights offers flight deals from Columbia to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Columbia to South Carolina

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Top airline flying from Columbia to South Carolina

Discover the top airline that operate flights from Columbia to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$410Average$488FlexibilityNo cancel feeOn-time71%

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