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South Carolina

$221+ Cheap flights from Columbia, MO (COU) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/3. Fares are subject to change and may not be available on all flights or dates of travel.
COU — CHS
Apr 9 — Apr 161
Thu 4/9
Thu 4/16
1 adult, Economy
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Cheap flight deals from Columbia to South Carolina

Cheapest flights from Columbia to South Carolina
Explore the most affordable flight options available from Columbia to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.

This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:00 am
COU
-
HHH
2 stops7h 24m
American Airlines
Tue 5/262:05 pm
HHH
-
COU
1 stop4h 57m
American Airlines
Deal found 3/6$310
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:00 am
COU
-
MYR
1 stop5h 17m
United Airlines
Sat 4/183:15 pm
MYR
-
COU
1 stop7h 46m
United Airlines
Deal found 3/9$313
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/255:00 am
COU
-
CLT
2 stops8h 12m
United Airlines
Mon 6/296:35 pm
CLT
-
COU
1 stop6h 55m
United Airlines
Deal found 3/7$319
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/283:05 pm
COU
-
CLT
1 stop5h 24m
United Airlines
Mon 6/18:05 am
CLT
-
COU
1 stop7h 25m
United Airlines
Deal found 3/8$340
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/283:23 pm
COU
-
CLT
1 stop4h 40m
United Airlines
Sat 5/26:15 am
CLT
-
COU
1 stop5h 40m
United Airlines
Deal found 3/8$348
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/223:05 pm
COU
-
CHS
1 stop5h 43m
United Airlines
Tue 8/258:55 am
CHS
-
COU
1 stop6h 35m
United Airlines
Deal found 3/8$348
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/312:27 pm
COU
-
CHS
1 stop8h 08m
American Airlines
Tue 4/74:41 pm
CHS
-
COU
1 stop7h 12m
American Airlines
Deal found 3/8$359
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/57:00 am
COU
-
MYR
1 stop6h 18m
American Airlines
Tue 8/116:00 pm
MYR
-
COU
1 stop5h 35m
American Airlines
Deal found 3/8$359
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:00 am
COU
-
MYR
1 stop5h 04m
American Airlines
Sat 4/185:00 am
MYR
-
COU
2 stops11h 58m
American Airlines
Deal found 3/9$364
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/242:41 pm
COU
-
CLT
1 stop5h 50m
United Airlines
Sat 3/288:00 am
CLT
-
COU
1 stop7h 06m
United Airlines
Deal found 3/6$375
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/48:00 am
COU
-
MYR
1 stop5h 17m
United Airlines
Sat 4/113:15 pm
MYR
-
COU
1 stop7h 46m
United Airlines
Deal found 3/7$376
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/247:16 am
COU
-
MYR
1 stop4h 19m
American Airlines
Sat 5/306:12 pm
MYR
-
COU
1 stop5h 34m
American Airlines
Deal found 3/9$392

Find flight deals from Columbia to South Carolina

Keep the following information in mind while searching for Columbia to South Carolina flight deals. Data was last updated March 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$310
(American Airlines)

One-way from

$221
(Kiwi.com)
Provider with most accurate pricing for Columbia Regional-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Columbia Regional-Myrtle Beach Intl flights.
Search Deals
From Columbia Regional to South Carolina
Search Deals
One-way flight from Columbia Regional to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from Columbia to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbiaHilton Head Island

COU - HHH

COUHHH

Columbia Regional

Tue 5/12

6:00 am-2:24 pm

2 stops7h 24m

Hilton Head Island

Tue 5/26

2:05 pm-6:02 pm

1 stop4h 57m

$310

ColumbiaMyrtle Beach

COU - MYR

COUMYR

Columbia Regional

Mon 4/13

8:00 am-2:17 pm

1 stop5h 17m

Myrtle Beach Intl

Sat 4/18

3:15 pm-10:01 pm

1 stop7h 46m

$313

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Thu 6/25

5:00 am-2:12 pm

2 stops8h 12m

Charlotte Douglas

Mon 6/29

6:35 pm-12:30 am

1 stop6h 55m

$319

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Thu 5/28

11:23 am-11:59 pm

2 stops11h 36m

Charlotte Douglas

Mon 6/1

8:05 am-2:30 pm

1 stop7h 25m

$345

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Fri 4/3

12:27 pm-9:35 pm

1 stop8h 08m

Charleston

Wed 4/8

7:00 am-11:35 am

1 stop5h 35m

$348

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Sat 6/27

3:05 pm-9:29 pm

1 stop5h 24m

Charlotte Douglas

Tue 7/7

6:15 am-10:48 am

1 stop5h 33m

$348
Quickest round-trip

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Tue 4/28

3:23 pm-9:03 pm

1 stop4h 40m

Charlotte Douglas

Sat 5/2

10:34 am-2:32 pm

1 stop4h 58m

$348

ColumbiaCharlotte

COU - CLT

COUCLT

Columbia Regional

Sun 4/5

11:30 am-5:24 pm

1 stop4h 54m

Charlotte Douglas

Sun 4/12

6:15 am-10:55 am

1 stop5h 40m

$348

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Sat 4/4

11:30 am-5:13 pm

1 stop4h 43m

Charleston

Wed 4/8

8:00 am-2:48 pm

1 stop7h 48m

$348

ColumbiaCharleston

COU - CHS

COUCHS

Columbia Regional

Fri 4/3

12:27 pm-9:35 pm

1 stop8h 08m

Charleston

Tue 4/7

2:13 pm-9:30 pm

2 stops8h 17m

$364

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/5

Showing 1-10 of 33 resultsSorted by cheapest first
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Best time to book a flight from Columbia to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbia to South Carolina
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 10, 2026.
See what other customers who have flown with American Airlines from Columbia to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,414 reviews

Food

6.4

Overall

7.1

Boarding

7.5

Comfort

7.2

Crew

7.9

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes
American Airlines
7.1
Good
11,414 reviews
American Airlines
7.1
Good
11,414 reviews

Food

6.4

Overall

7.1

Boarding

7.5

Comfort

7.2

Crew

7.9

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes

Related info for your journey

Find useful and relevant information for your journey from Columbia to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Columbia to South Carolina?

    Columbia Regional (COU), located 11.1 mi from the city center, is the airport you fly out of when you book flights from Columbia to South Carolina.

  • How long is the flight from Columbia, Missouri to South Carolina?

    Departing from Columbia, Missouri to South Carolina will take you 5h 17m. There are 820 mi between Columbia, Missouri and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Columbia, Missouri to South Carolina?

    When deciding which route to take from Columbia, Missouri to South Carolina consider Columbia Regional - Charlotte Douglas, Columbia Regional - Myrtle Beach Intl or Columbia Regional - Charleston as they are the most popular.

  • Can I find deals for flights from Columbia to South Carolina that include hotel bookings?

    Yes. In addition to deals on Columbia to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to South Carolina.

  • Can I find deals for business class flights from Columbia to South Carolina?

    Yes. Cheapflights offers flight deals from Columbia to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Columbia to South Carolina

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Top airline flying from Columbia to South Carolina

Discover the top airline that operate flights from Columbia to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$410Average$488FlexibilityNo cancel feeOn-time71%

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