$58+ Cheap flights from Chicago (CHI) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/30. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — CHS
Apr 14 — Apr 211
Round-trip
1 adult, Economy
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Find cheap flights from Chicago to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Chicago to South Carolina
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Cheapest flights from Chicago to South CarolinaExplore the most affordable flight options available from Chicago to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 15, 2026.
Explore the most affordable flight options available from Chicago to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 15, 2026.
This Super.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3012:16 pm
ORD
- CLT
Nonstop2h 08m
Frontier
Mon 5/44:40 pm
CLT
- ORD
Nonstop2h 34m
Frontier
Deal found 3/11![Frontier logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/181:27 pm
ORD
- CLT
1 stop7h 31m
Frontier
Thu 4/234:19 pm
CLT
- ORD
Nonstop2h 34m
Frontier
Deal found 3/10![Frontier logo]()
$117
This Expedia deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2312:16 pm
ORD
- CLT
Nonstop2h 08m
Frontier
Mon 4/273:12 pm
CLT
- ORD
1 stop25h 05m
Frontier
Deal found 3/15![Frontier logo]()
$118
This Mytrip deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3012:16 pm
ORD
- CLT
Nonstop2h 08m
Multiple Airlines
Mon 5/49:54 pm
CLT
- ORD
1 stop12h 37m
Multiple Airlines
Deal found 3/14![Multiple Airlines logo]()
$121
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/91:02 pm
ORD
- CLT
Nonstop2h 10m
Frontier
Mon 4/139:40 pm
CLT
- ORD
Nonstop2h 27m
Frontier
Deal found 3/12![Frontier logo]()
$122
This Expedia deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/192:00 pm
ORD
- CLT
Nonstop2h 16m
Frontier
Mon 4/203:12 pm
CLT
- ORD
1 stop25h 05m
Frontier
Deal found 3/12![Frontier logo]()
$123
This Priceline deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:01 pm
ORD
- CLT
1 stop4h 52m
Multiple Airlines
Fri 4/1010:43 pm
CLT
- ORD
Nonstop2h 21m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$124
This Super.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/113:00 pm
ORD
- CLT
Nonstop2h 14m
Frontier
Mon 4/139:40 pm
CLT
- ORD
Nonstop2h 27m
Frontier
Deal found 3/14![Frontier logo]()
$127
This Frontier deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/51:02 pm
ORD
- CLT
Nonstop2h 10m
Frontier
Fri 4/1010:43 pm
CLT
- ORD
Nonstop2h 21m
Frontier
Deal found 3/10![Frontier logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/46:01 pm
ORD
- CLT
1 stop4h 52m
Multiple Airlines
Mon 4/139:40 pm
CLT
- ORD
Nonstop2h 27m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:30 am
MDW
- CLT
1 stop13h 31m
Multiple Airlines
Thu 4/236:30 pm
CLT
- MDW
1 stop24h 24m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$175
This CheapOair deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/199:04 am
MDW
- CLT
1 stop23h 33m
Frontier
Thu 4/236:30 pm
CLT
- MDW
1 stop24h 24m
Frontier
Deal found 3/10![Frontier logo]()
$191
Best flights from Chicago to South CarolinaDiscover carefully curated flight deals from Chicago to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 15, 2026.
Discover carefully curated flight deals from Chicago to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 15, 2026.
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/209:00 am
MDW
- CLT
2 stops8h 45m
Southwest
Sun 4/267:00 am
CLT
- MDW
Nonstop2h 00m
Southwest
Deal found 3/10![Southwest logo]()
$232
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:07 am
ORD
- GSP
1 stop3h 58m
Delta
Sun 5/177:20 am
GSP
- ORD
1 stop4h 07m
Delta
Deal found 3/10![Delta logo]()
$233
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1010:45 am
ORD
- HHH
Nonstop2h 36m
United Airlines
Thu 7/163:05 pm
HHH
- ORD
Nonstop2h 46m
United Airlines
Deal found 3/12![United Airlines logo]()
$249
This KAYAK deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/283:26 pm
ORD
- CLT
Nonstop2h 15m
American Airlines
Thu 4/3011:25 am
CLT
- ORD
1 stop3h 47m
American Airlines
Deal found 3/13![American Airlines logo]()
$317
This Contour deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Contour is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2111:20 am
ORD
- CLT
1 stop4h 40m
Contour
Mon 5/256:05 pm
CLT
- ORD
1 stop23h 10m
Contour
Deal found 3/12![Contour logo]()
$325
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/195:15 am
ORD
- CLT
1 stop4h 56m
Delta
Thu 4/2312:40 pm
CLT
- ORD
1 stop7h 12m
Delta
Deal found 3/10![Delta logo]()
$237
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/711:40 am
MDW
- CLT
2 stops6h 05m
Southwest
Sun 5/108:50 pm
CLT
- MDW
1 stop4h 30m
Southwest
Deal found 3/11![Southwest logo]()
$242
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1710:45 am
ORD
- HHH
Nonstop2h 36m
United Airlines
Mon 6/223:05 pm
HHH
- ORD
Nonstop2h 46m
United Airlines
Deal found 3/10![United Airlines logo]()
$249
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/83:50 pm
MDW
- CLT
1 stop5h 50m
Southwest
Sun 5/106:10 am
CLT
- MDW
2 stops7h 00m
Southwest
Deal found 3/10![Southwest logo]()
$242
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:00 am
MDW
- CLT
1 stop6h 43m
Delta
Mon 4/209:36 am
CLT
- MDW
1 stop4h 07m
Delta
Deal found 3/14![Delta logo]()
$257
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/128:45 am
ORD
- GSP
1 stop4h 32m
United Airlines
Sun 5/176:36 am
GSP
- ORD
Nonstop2h 24m
United Airlines
Deal found 3/12![United Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:40 pm
ORD
- GSP
1 stop6h 35m
Southwest
Tue 4/216:45 am
GSP
- ORD
1 stop7h 05m
Southwest
Deal found 3/10![Southwest logo]()
$249
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/301:36 pm
ORD
- CLT
1 stop6h 52m
Delta
Sun 5/36:00 am
CLT
- ORD
1 stop5h 19m
Delta
Deal found 3/14![Delta logo]()
$257
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/298:50 am
ORD
- GSP
Nonstop2h 04m
United Airlines
Fri 5/16:36 am
GSP
- ORD
Nonstop2h 24m
United Airlines
Deal found 3/12![United Airlines logo]()
$278
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/82:40 pm
ORD
- GSP
1 stop6h 00m
Southwest
Fri 4/106:25 am
GSP
- ORD
1 stop7h 25m
Southwest
Deal found 3/10![Southwest logo]()
$254
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/247:10 am
ORD
- CAE
1 stop4h 18m
Delta
Wed 7/291:20 pm
CAE
- ORD
1 stop4h 24m
Delta
Deal found 3/10![Delta logo]()
$269
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/171:42 pm
ORD
- CAE
Nonstop2h 13m
United Airlines
Sun 4/197:38 pm
CAE
- ORD
1 stop5h 05m
United Airlines
Deal found 3/11![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2111:55 am
ORD
- GSP
2 stops8h 45m
Southwest
Wed 4/226:45 am
GSP
- ORD
1 stop7h 05m
Southwest
Deal found 3/10![Southwest logo]()
$254
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/238:10 am
ORD
- CAE
1 stop5h 57m
Delta
Fri 5/297:17 pm
CAE
- ORD
1 stop5h 42m
Delta
Deal found 3/11![Delta logo]()
$269
This United Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:10 pm
ORD
- GSP
Nonstop2h 07m
United Airlines
Mon 7/67:40 pm
GSP
- ORD
1 stop4h 46m
United Airlines
Deal found 3/14![United Airlines logo]()
$291
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/305:30 am
MDW
- CLT
1 stop5h 35m
Southwest
Mon 5/48:30 pm
CLT
- MDW
1 stop4h 00m
Southwest
Deal found 3/14![Southwest logo]()
$267
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/28:15 am
ORD
- GSP
1 stop5h 02m
Delta
Mon 5/47:59 pm
GSP
- ORD
1 stop5h 00m
Delta
Deal found 3/12![Delta logo]()
$269
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:01 pm
ORD
- SAV
1 stop4h 58m
United Airlines
Sat 4/185:45 am
SAV
- ORD
1 stop6h 42m
United Airlines
Deal found 3/12![United Airlines logo]()
$291
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:00 am
ORD
- GSP
1 stop6h 08m
Delta
Tue 8/45:05 pm
GSP
- ORD
1 stop5h 11m
Delta
Deal found 3/12![Delta logo]()
$269
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/308:35 am
MDW
- CLT
Nonstop2h 00m
Southwest
Wed 6/37:20 pm
CLT
- MDW
1 stop3h 55m
Southwest
Deal found 3/14![Southwest logo]()
$269
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2511:00 am
ORD
- MYR
Nonstop2h 17m
United Airlines
Tue 4/283:15 pm
MYR
- ORD
Nonstop2h 31m
United Airlines
Deal found 3/11![United Airlines logo]()
$294
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:00 am
ORD
- GSP
1 stop4h 53m
Delta
Mon 8/33:42 pm
GSP
- ORD
1 stop5h 36m
Delta
Deal found 3/12![Delta logo]()
$269
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/181:55 pm
ORD
- GSP
1 stop5h 45m
Southwest
Mon 4/206:25 am
GSP
- ORD
1 stop7h 25m
Southwest
Deal found 3/14![Southwest logo]()
$275
This United Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/84:20 pm
ORD
- CHS
1 stop6h 39m
United Airlines
Mon 4/138:00 am
CHS
- ORD
Nonstop2h 36m
United Airlines
Deal found 3/14![United Airlines logo]()
$295
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/99:35 am
MDW
- CLT
1 stop5h 31m
Delta
Thu 4/166:00 am
CLT
- MDW
1 stop3h 47m
Delta
Deal found 3/11![Delta logo]()
$277
Last-minute flights from Chicago to South CarolinaDiscover last-minute flight deals from Chicago to South Carolina. Data last updated March 15, 2026 and is based on user searches.
Discover last-minute flight deals from Chicago to South Carolina. Data last updated March 15, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/46:01 pm
ORD
- CLT
1 stop4h 52m
Multiple Airlines
Mon 4/139:40 pm
CLT
- ORD
Nonstop2h 27m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$129
This Frontier deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/51:02 pm
ORD
- CLT
Nonstop2h 10m
Frontier
Fri 4/1010:43 pm
CLT
- ORD
Nonstop2h 21m
Frontier
Deal found 3/10![Frontier logo]()
$128
This Priceline deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:01 pm
ORD
- CLT
1 stop4h 52m
Multiple Airlines
Fri 4/1010:43 pm
CLT
- ORD
Nonstop2h 21m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$124
This Super.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/91:02 pm
ORD
- CLT
Nonstop2h 10m
Frontier
Fri 4/1010:43 pm
CLT
- ORD
Nonstop2h 21m
Frontier
Deal found 3/11![Frontier logo]()
$122
This Super.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/113:00 pm
ORD
- CLT
Nonstop2h 14m
Frontier
Mon 4/139:40 pm
CLT
- ORD
Nonstop2h 27m
Frontier
Deal found 3/14![Frontier logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/181:27 pm
ORD
- CLT
1 stop7h 31m
Frontier
Thu 4/234:19 pm
CLT
- ORD
Nonstop2h 34m
Frontier
Deal found 3/10![Frontier logo]()
$117
This Expedia deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/192:00 pm
ORD
- CLT
Nonstop2h 16m
Frontier
Mon 4/203:12 pm
CLT
- ORD
1 stop25h 05m
Frontier
Deal found 3/12![Frontier logo]()
$123
This CheapOair deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/199:04 am
MDW
- CLT
1 stop23h 33m
Frontier
Thu 4/236:30 pm
CLT
- MDW
1 stop24h 24m
Frontier
Deal found 3/10![Frontier logo]()
$191
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:30 am
MDW
- CLT
1 stop13h 31m
Multiple Airlines
Thu 4/236:30 pm
CLT
- MDW
1 stop24h 24m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$175
This Expedia deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2312:16 pm
ORD
- CLT
Nonstop2h 08m
Frontier
Mon 4/273:12 pm
CLT
- ORD
1 stop25h 05m
Frontier
Deal found 3/15![Frontier logo]()
$118
This Super.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3012:16 pm
ORD
- CLT
Nonstop2h 08m
Frontier
Mon 5/44:40 pm
CLT
- ORD
Nonstop2h 34m
Frontier
Deal found 3/11![Frontier logo]()
$115
This Mytrip deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3012:16 pm
ORD
- CLT
Nonstop2h 08m
Multiple Airlines
Mon 5/49:54 pm
CLT
- ORD
1 stop12h 37m
Multiple Airlines
Deal found 3/14![Multiple Airlines logo]()
$121
One-way flights from Chicago to South CarolinaSearch for one-way flight options from Chicago to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 15, 2026.
Search for one-way flight options from Chicago to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 15, 2026.
This Frontier deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3012:16 pm
ORD
- CLT
Nonstop2h 08m
Frontier
Deal found 3/10![Frontier logo]()
$58
This CheapOair deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/307:05 pm
ORD
- CLT
Nonstop2h 02m
Frontier
Deal found 3/10![Frontier logo]()
$64
This Super.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/21:02 pm
ORD
- CLT
Nonstop2h 10m
Frontier
Deal found 3/12![Frontier logo]()
$67
This Cheapflightsfares deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:01 pm
ORD
- CLT
1 stop4h 52m
Spirit Airlines
Deal found 3/12![Spirit Airlines logo]()
$69
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/319:30 am
MDW
- CLT
1 stop8h 43m
Frontier
Deal found 3/11![Frontier logo]()
$71
This Super.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/237:11 pm
ORD
- CLT
Nonstop2h 02m
Frontier
Deal found 3/10![Frontier logo]()
$72
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/147:30 am
MDW
- CLT
1 stop9h 04m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$73
This Super.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2412:37 pm
ORD
- CLT
Nonstop2h 08m
Frontier
Deal found 3/12![Frontier logo]()
$73
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/147:30 am
MDW
- SAV
1 stop7h 25m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$74
This Frontier deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:31 pm
ORD
- CLT
Nonstop2h 17m
Frontier
Deal found 3/11![Frontier logo]()
$74
This Super.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/46:01 pm
ORD
- CLT
1 stop4h 52m
Spirit Airlines
Deal found 3/12![Spirit Airlines logo]()
$76
This Mytrip deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:01 pm
ORD
- CHS
1 stop16h 08m
Spirit Airlines
Deal found 3/12![Spirit Airlines logo]()
$77
Find flight deals from Chicago to South Carolina
Keep the following information in mind while searching for Chicago to South Carolina flight deals. Data was last updated March 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $111 (Kiwi.com) |
One-way from | $58 (Frontier) |
Popular in | December |
Cheapest in | August |
Average price | $435 |
Good round-trip deal | $271 or less |
Good one-way deal | $128 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Chicago to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 15, 2026.
Use the filters below to find and compare flights from Chicago to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoCharlotte
MDW - CLT
MDWCLT
Chicago Midway
Mon 4/20
9:00 am-6:45 pm
2 stops8h 45m
Charlotte Douglas
Sun 4/26
7:00 am-8:00 am
Nonstop2h 00m
$232
ChicagoGreenville
ORD - GSP
ORDGSP
Chicago O'Hare Intl
Tue 5/12
7:07 am-12:05 pm
1 stop3h 58m
Greenville
Sun 5/17
7:20 am-10:27 am
1 stop4h 07m
$233
ChicagoCharlotte
ORD - CLT
ORDCLT
Chicago O'Hare Intl
Sun 4/19
5:15 am-11:11 am
1 stop4h 56m
Charlotte Douglas
Thu 4/23
12:40 pm-6:52 pm
1 stop7h 12m
$237
ChicagoCharlotte
MDW - CLT
MDWCLT
Chicago Midway
Thu 5/7
11:40 am-6:45 pm
2 stops6h 05m
Charlotte Douglas
Sun 5/10
8:50 pm-12:20 am
1 stop4h 30m
$242
ChicagoCharlotte
MDW - CLT
MDWCLT
Chicago Midway
Fri 5/8
3:50 pm-10:40 pm
1 stop5h 50m
Charlotte Douglas
Sun 5/10
6:10 am-12:10 pm
2 stops7h 00m
$242
ChicagoHilton Head Island
ORD - HHH
ORDHHH
Chicago O'Hare Intl
Fri 7/10
10:45 am-2:21 pm
Nonstop2h 36m
Hilton Head Island
Thu 7/16
3:05 pm-4:51 pm
Nonstop2h 46m
$249
ChicagoHilton Head Island
ORD - HHH
ORDHHH
Chicago O'Hare Intl
Wed 6/17
10:45 am-2:21 pm
Nonstop2h 36m
Hilton Head Island
Mon 6/22
3:05 pm-4:51 pm
Nonstop2h 46m
$249
ChicagoGreenville
ORD - GSP
ORDGSP
Chicago O'Hare Intl
Mon 4/20
2:40 pm-10:15 pm
1 stop6h 35m
Greenville
Tue 4/21
6:45 am-12:50 pm
1 stop7h 05m
$249
ChicagoGreenville
ORD - GSP
ORDGSP
Chicago O'Hare Intl
Wed 4/8
2:40 pm-9:40 pm
1 stop6h 00m
Greenville
Fri 4/10
6:25 am-12:50 pm
1 stop7h 25m
$254
ChicagoGreenville
ORD - GSP
ORDGSP
Chicago O'Hare Intl
Tue 4/21
11:55 am-9:40 pm
2 stops8h 45m
Greenville
Wed 4/22
6:45 am-12:50 pm
1 stop7h 05m
$254
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Chicago to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Chicago with our price prediction graph.
MDW-CLT
ORD-GSP
ORD-HHH
ORD-CLT
ORD-CAE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Chicago to South Carolina
CHI-USSC
MDW-CLT
ORD-GSP
ORD-HHH
ORD-CLT
What is the cheapest month to book a flight from Chicago to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Chicago to South Carolina (average of $61). Flying from Chicago to South Carolina in March is currently the most expensive (average of $208). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from CHI to SC?
Find hourly flight availability from Chicago to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 15, 2026.
It’s typically best to fly out from Chicago to South Carolina in the evening. Doing so could potentially save you 21% on the flight price compared to flying in the morning, which is usually more expensive.
What is the cheapest day to fly from Chicago to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Chicago to South Carolina. Price data was last updated on March 14, 2026.
Travelers seeking maximum savings on their Chicago to South Carolina flight should consider departing on Monday evenings when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
Weekly flight availability from Chicago to South Carolina
Explore weekly flight availability from Chicago to South Carolina. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated March 15, 2026.
The most flights from CHI to USSC are scheduled on a Friday (23 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (9 on average).
How much does it cost to fly round-trip from Chicago to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 15, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Chicago to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Related info for your journey
Find useful and relevant information for your journey from Chicago to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Chicago to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Chicago to South Carolina by cabin class
Find flights from Chicago to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Chicago and South Carolina flights
Browse other Chicago and South Carolina flight options. Last updated on March 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Chicago to South Carolina flights
Consider these flights traveling from Chicago to South Carolina.
Top 5 airlines flying from Chicago to South Carolina
Discover the top 5 airlines that operate flights from Chicago to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$51 | Average$164 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$118 | Average$297 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$153 | Average$386 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$153 | Average$368 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$202 | Average$361 | FlexibilityNo cancel fee | On-time71% |