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South Carolina

$81+ Cheap flights from Buffalo (BUF) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
Aug 4 — Aug 111
Mon 8/4
Mon 8/11
1 adult, Economy
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Cheap flight deals from Buffalo to South Carolina

Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated July 30, 2025.

Round-trip from

$181
(Priceline)

One-way from

$81
(Priceline)

Popular in

April

Cheapest in

September

Average price

$376
From Buffalo to South Carolina
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One-way flight from Buffalo to South Carolina
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Highest demand for flights based on searches. 8% potential increase in price ($34 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Buffalo to South Carolina

Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

This Priceline deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/136:00 amBUF - CHS
1 stop4h 25mJetBlue
Tue 9/1611:10 amCHS - BUF
1 stop7h 54mJetBlue
Deal found 7/29$181
This FlightHub deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/149:07 pmBUF - CLT
1 stop16h 15mFrontier
Sat 8/169:37 pmCLT - BUF
1 stop18h 39mFrontier
Deal found 7/28$195
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/236:00 amBUF - CLT
1 stop7h 31mAmerican Airlines
Sat 8/234:45 pmCLT - BUF
Nonstop1h 45mAmerican Airlines
Deal found 7/28$214
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/315:14 amBUF - MYR
1 stop6h 42mAmerican Airlines
Tue 11/412:47 pmMYR - BUF
1 stop4h 06mAmerican Airlines
Deal found 7/28$216
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/167:05 amBUF - SAV
1 stop5h 14mUnited Airlines
Tue 9/231:15 pmSAV - BUF
1 stop8h 01mUnited Airlines
Deal found 7/28$221
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/245:45 amBUF - SAV
1 stop4h 15mSouthwest
Sun 8/318:20 amSAV - BUF
1 stop4h 05mSouthwest
Deal found 7/27$224
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/166:00 amBUF - SAV
2 stops6h 31mAmerican Airlines
Tue 9/2311:11 amSAV - BUF
1 stop5h 50mAmerican Airlines
Deal found 7/29$226
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/3012:18 pmBUF - MYR
1 stop5h 29mDelta
Sat 9/66:35 pmMYR - BUF
1 stop4h 24mDelta
Deal found 7/28$227
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/291:15 pmBUF - SAV
1 stop8h 11mDelta
Sat 11/17:15 amSAV - BUF
1 stop3h 55mDelta
Deal found 7/30$229
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/236:00 amBUF - GSP
1 stop6h 28mAmerican Airlines
Thu 10/26:00 amGSP - BUF
1 stop5h 00mAmerican Airlines
Deal found 7/30$237
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/67:40 amBUF - CHS
1 stop5h 59mAmerican Airlines
Sun 9/75:00 amCHS - BUF
1 stop6h 00mAmerican Airlines
Deal found 7/30$237
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/37:40 amBUF - CLT
2 stops8h 55mSouthwest
Tue 9/96:35 pmCLT - BUF
1 stop4h 25mSouthwest
Deal found 7/29$242

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Buffalo

Fly to

South Carolina

Route

Depart

Return

Price

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Sat 9/13

6:00 am-10:25 am

1 stop4h 25m

Charleston

Tue 9/16

11:10 am-7:04 pm

1 stop7h 54m

$181

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Thu 8/14

9:07 pm-1:22 pm

1 stop16h 15m

Charlotte Douglas

Sat 8/16

9:37 pm-4:16 pm

1 stop18h 39m

$195

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Sat 8/23

6:00 am-1:31 pm

1 stop7h 31m

Charlotte Douglas

Sat 8/23

4:45 pm-6:30 pm

Nonstop1h 45m

$214

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Fri 10/31

5:14 am-11:56 am

1 stop6h 42m

Myrtle Beach Intl

Tue 11/4

12:47 pm-4:53 pm

1 stop4h 06m

$216

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Tue 9/16

7:05 am-12:19 pm

1 stop5h 14m

Savannah/Hilton Head

Tue 9/23

1:15 pm-9:16 pm

1 stop8h 01m

$221

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Sun 8/24

5:45 am-10:00 am

1 stop4h 15m

Savannah/Hilton Head

Sun 8/31

8:20 am-12:25 pm

1 stop4h 05m

$224

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Tue 9/16

6:00 am-12:31 pm

2 stops6h 31m

Savannah/Hilton Head

Tue 9/23

11:11 am-5:01 pm

1 stop5h 50m

$226

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Sat 8/30

12:18 pm-5:47 pm

1 stop5h 29m

Myrtle Beach Intl

Sat 9/6

6:35 pm-10:59 pm

1 stop4h 24m

$227

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Wed 10/8

7:30 pm-11:58 pm

1 stop4h 28m

Savannah/Hilton Head

Mon 10/13

5:40 am-11:10 am

1 stop5h 30m

$229

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Tue 9/23

6:00 am-12:28 pm

1 stop6h 28m

Greenville

Thu 10/2

6:00 am-11:00 am

1 stop5h 00m

$237

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Showing 1-10 of 58 results
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Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $217). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to SC?

Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 30, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Buffalo to South Carolina as you normally would.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated July 30, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,980 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,896 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
JetBlue
7.3
Good
2,913 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to South Carolina?

    Buffalo (BUF) is the airport you will fly out of if you book a flight from Buffalo to South Carolina. It is only a 8.3 mi journey to Buffalo (BUF) from Buffalo’s city center.

  • What are the cheapest airlines to fly from Buffalo to South Carolina one-way?

    The cheapest airlines for a one-way flight from Buffalo to South Carolina are JetBlue ($81), Frontier ($97), and American Airlines ($100).

  • What are the most popular routes from Buffalo to South Carolina?

    While some choose either Buffalo - Myrtle Beach Intl or Buffalo - Savannah/Hilton Head, Buffalo - Charlotte Douglas is the most popular route from Buffalo to South Carolina.

  • Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.

  • Can I find deals for business class flights from Buffalo to South Carolina?

    Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $217). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Buffalo to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Buffalo to South Carolina

Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$80Average$201FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$196Average$388FlexibilityNo cancel feeOn-time71%
DeltaCheapest$196Average$309FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$218Average$406FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$234Average$377FlexibilityNo cancel feeOn-time69%

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