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South Carolina

$77+ Cheap flights from Buffalo (BUF) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
oct. 15 — oct. 221
mié. 10/15
mié. 10/22
1 adult, Economy
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Cheap flight deals from Buffalo to South Carolina

Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated septiembre 15, 2025.

Round-trip from

$181
(JetBlue)

One-way from

$77
(Kiwi.com)

Popular in

April

Cheapest in

September

Average price

$314
From Buffalo to South Carolina
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One-way flight from Buffalo to South Carolina
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Highest demand for flights based on searches. 8% potential increase in price ($35 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Buffalo to South Carolina

Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 15, 2025.

This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/226:00 amBUF - CHS
1 stop4h 25mJetBlue
jue. 10/306:05 amCHS - BUF
1 stop5h 14mJetBlue
Deal found 9/15$181
This JetBlue deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/307:00 amBUF - CHS
1 stop6h 19mJetBlue
dom. 11/25:05 amCHS - BUF
1 stop5h 14mJetBlue
Deal found 9/15$201
This JetBlue deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/206:00 amBUF - SAV
1 stop5h 40mJetBlue
mié. 10/2912:25 pmSAV - BUF
1 stop6h 47mJetBlue
Deal found 9/14$207
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/16:45 pmBUF - MYR
1 stop4h 20mAmerican Airlines
lun. 10/68:20 pmMYR - BUF
1 stop3h 55mAmerican Airlines
Deal found 9/12$214
This JetBlue deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/226:00 amBUF - SAV
1 stop5h 40mJetBlue
mar. 10/2811:19 amSAV - BUF
1 stop4h 20mJetBlue
Deal found 9/14$214
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/175:34 amBUF - SAV
1 stop7h 13mAmerican Airlines
sáb. 1/177:49 amSAV - BUF
1 stop7h 08mAmerican Airlines
Deal found 9/13$216
This Expedia deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/307:00 amBUF - SAV
1 stop8h 15mJetBlue
mar. 10/711:16 amSAV - BUF
1 stop6h 35mJetBlue
Deal found 9/14$224
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/285:14 amBUF - HHH
1 stop5h 32mAmerican Airlines
mar. 11/47:07 pmHHH - BUF
1 stop4h 19mAmerican Airlines
Deal found 9/14$227
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/247:30 pmBUF - SAV
1 stop4h 28mDelta
mar. 10/285:37 pmSAV - BUF
1 stop6h 02mDelta
Deal found 9/14$233
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/211:14 pmBUF - CLT
Nonstop2h 02mAmerican Airlines
sáb. 10/252:53 pmCLT - BUF
1 stop8h 42mAmerican Airlines
Deal found 9/12$238
This JetBlue deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/46:00 amBUF - SAV
1 stop5h 39mJetBlue
mié. 10/84:10 pmSAV - BUF
1 stop4h 50mJetBlue
Deal found 9/14$239
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/26:22 pmBUF - CLT
2 stops17h 21mMultiple Airlines
lun. 10/67:20 amCLT - BUF
1 stop10h 54mMultiple Airlines
Deal found 9/14$239

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 15, 2025.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Buffalo

Fly to

South Carolina

Route

Depart

Return

Price

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

mié. 10/22

6:00 am-10:25 am

1 stop4h 25m

Charleston

jue. 10/30

6:05 am-11:19 am

1 stop5h 14m

$181

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

jue. 10/30

7:00 am-1:19 pm

1 stop6h 19m

Charleston

dom. 11/2

5:05 am-10:19 am

1 stop5h 14m

$201

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

lun. 10/20

6:00 am-11:40 am

1 stop5h 40m

Savannah/Hilton Head

mié. 10/29

12:25 pm-7:12 pm

1 stop6h 47m

$207

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

mar. 10/21

6:00 am-11:40 am

1 stop5h 40m

Savannah/Hilton Head

mié. 10/29

12:25 pm-7:12 pm

1 stop6h 47m

$207

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

mar. 10/21

7:00 am-3:15 pm

1 stop8h 15m

Savannah/Hilton Head

mar. 10/28

11:19 am-3:39 pm

1 stop4h 20m

$207

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

lun. 10/20

6:00 am-11:40 am

1 stop5h 40m

Savannah/Hilton Head

mar. 10/28

11:19 am-3:39 pm

1 stop4h 20m

$207

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

mié. 10/22

6:00 am-11:40 am

1 stop5h 40m

Savannah/Hilton Head

mié. 10/29

12:25 pm-7:12 pm

1 stop6h 47m

$214

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

vie. 10/31

9:00 am-6:00 pm

2 stops9h 00m

Savannah/Hilton Head

lun. 11/3

7:05 am-12:05 pm

1 stop5h 00m

$221

BuffaloHilton Head Island

BUF - HHH

BUFHHH

Buffalo

mar. 10/28

5:14 am-10:46 am

1 stop5h 32m

Hilton Head Island

mar. 11/4

7:07 pm-11:26 pm

1 stop4h 19m

$227

BuffaloHilton Head Island

BUF - HHH

BUFHHH

Buffalo

mié. 10/29

10:30 am-4:51 pm

1 stop6h 21m

Hilton Head Island

mar. 11/4

1:02 pm-5:48 pm

1 stop4h 46m

$227

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 60 results
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Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $217). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to SC?

Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 15, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Buffalo to South Carolina as you normally would.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated septiembre 15, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Overall

8.0

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Overall

8.0

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,954 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Overall

8.0

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,929 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Overall

8.0

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Overall

8.0

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
JetBlue
7.2
Good
2,912 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Overall

8.0

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to South Carolina?

    Buffalo (BUF) is the airport you will fly out of if you book a flight from Buffalo to South Carolina. It is only a 8.3 mi journey to Buffalo (BUF) from Buffalo’s city center.

  • How long is the flight from Buffalo to South Carolina?

    Airlines like JetBlue, American Airlines, and Delta fly from Buffalo to South Carolina in about 4h 09m. The time it takes to get you to your destination can typically vary by up to 1h 23m. The distance between Buffalo and South Carolina is about 586 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Buffalo to South Carolina one-way?

    The cheapest airlines for a one-way flight from Buffalo to South Carolina are Frontier ($77), JetBlue ($111), and American Airlines ($126).

  • What are the most popular routes from Buffalo to South Carolina?

    While some choose either Buffalo - Greenville or Buffalo - Savannah/Hilton Head, Buffalo - Charlotte Douglas is the most popular route from Buffalo to South Carolina.

  • Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.

  • Can I find deals for business class flights from Buffalo to South Carolina?

    Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $217). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Buffalo to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Buffalo to South Carolina

Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$80Average$229FlexibilityNo cancel feeOn-time62%
DeltaCheapest$196Average$308FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$198Average$354FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$218Average$405FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$234Average$406FlexibilityNo cancel feeOn-time69%

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