$67+ Cheap flights from Buffalo (BUF) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/3. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
Mar 1 — Mar 81
1 adult, Economy
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Find cheap flights from Buffalo to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to South Carolina
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Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 30, 2026.
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/89:25 pm
BUF
- CLT
1 stop10h 33m
Frontier
Wed 3/119:08 am
CLT
- BUF
1 stop25h 41m
Frontier
Deal found 1/29![Frontier logo]()
$151
This JetBlue deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2810:25 am
BUF
- SAV
1 stop5h 57m
JetBlue
Thu 3/55:21 pm
SAV
- BUF
1 stop6h 11m
JetBlue
Deal found 1/28![JetBlue logo]()
$189
This CheapOair deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/98:59 pm
BUF
- CLT
1 stop12h 38m
Frontier
Thu 4/165:41 pm
CLT
- BUF
1 stop15h 06m
Frontier
Deal found 1/29![Frontier logo]()
$192
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/239:25 pm
BUF
- CLT
1 stop10h 38m
Frontier
Wed 3/251:59 pm
CLT
- BUF
1 stop20h 50m
Frontier
Deal found 1/28![Frontier logo]()
$200
This Frontier deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/133:00 pm
BUF
- CLT
1 stop9h 36m
Frontier
Mon 4/2011:15 am
CLT
- BUF
1 stop7h 58m
Frontier
Deal found 1/28![Frontier logo]()
$201
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/235:29 pm
BUF
- CHS
1 stop4h 19m
American Airlines
Mon 3/26:36 pm
CHS
- BUF
1 stop4h 13m
American Airlines
Deal found 1/27![American Airlines logo]()
$201
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:00 am
BUF
- SAV
1 stop4h 37m
United Airlines
Fri 5/293:14 pm
SAV
- BUF
1 stop5h 48m
United Airlines
Deal found 1/27![United Airlines logo]()
$203
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/284:25 pm
BUF
- SAV
2 stops7h 33m
American Airlines
Thu 3/56:09 pm
SAV
- BUF
1 stop5h 41m
American Airlines
Deal found 1/29![American Airlines logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/711:44 am
BUF
- CLT
1 stop21h 33m
Multiple Airlines
Tue 3/1010:39 pm
CLT
- BUF
2 stops36h 10m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$212
This CheapOair deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/711:25 am
BUF
- CLT
1 stop23h 05m
Frontier
Sat 5/98:05 pm
CLT
- BUF
1 stop23h 08m
Frontier
Deal found 1/29![Frontier logo]()
$213
This JetBlue deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2610:25 am
BUF
- SAV
1 stop5h 57m
JetBlue
Mon 3/25:25 pm
SAV
- BUF
1 stop6h 07m
JetBlue
Deal found 1/27![JetBlue logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/89:25 pm
BUF
- CLT
2 stops16h 52m
Multiple Airlines
Wed 3/111:59 pm
CLT
- BUF
1 stop20h 50m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$217
Best flights from Buffalo to South CarolinaDiscover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated January 30, 2026.
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated January 30, 2026.
This JetBlue deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2810:25 am
BUF
- SAV
1 stop5h 57m
JetBlue
Thu 3/55:21 pm
SAV
- BUF
1 stop6h 11m
JetBlue
Deal found 1/29![JetBlue logo]()
$197
This Delta deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:44 pm
BUF
- CHS
1 stop5h 11m
Delta
Tue 4/285:47 pm
CHS
- BUF
1 stop7h 02m
Delta
Deal found 1/30![Delta logo]()
$201
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:45 pm
BUF
- CHS
1 stop4h 35m
United Airlines
Tue 7/1411:55 am
CHS
- BUF
1 stop4h 52m
United Airlines
Deal found 1/28![United Airlines logo]()
$201
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/57:40 pm
BUF
- CHS
1 stop4h 15m
American Airlines
Wed 4/86:06 am
CHS
- BUF
1 stop5h 08m
American Airlines
Deal found 1/29![American Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/711:44 am
BUF
- MYR
1 stop21h 06m
Multiple Airlines
Wed 3/119:09 am
MYR
- BUF
2 stops25h 40m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/211:37 am
BUF
- CLT
1 stop26h 14m
Frontier
Sun 3/87:48 pm
CLT
- BUF
1 stop15h 01m
Frontier
Deal found 1/29![Frontier logo]()
$266
This Southwest deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:30 am
BUF
- SAV
2 stops12h 30m
Southwest
Mon 3/26:30 am
SAV
- BUF
1 stop7h 25m
Southwest
Deal found 1/29![Southwest logo]()
$276
This JetBlue deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2912:25 pm
BUF
- CHS
1 stop6h 40m
JetBlue
Mon 6/13:30 pm
CHS
- BUF
1 stop8h 25m
JetBlue
Deal found 1/30![JetBlue logo]()
$220
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/181:35 pm
BUF
- CHS
1 stop5h 33m
Delta
Sat 4/255:20 am
CHS
- BUF
1 stop5h 41m
Delta
Deal found 1/28![Delta logo]()
$221
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:45 pm
BUF
- SAV
1 stop4h 14m
United Airlines
Wed 4/159:15 am
SAV
- BUF
1 stop7h 55m
United Airlines
Deal found 1/28![United Airlines logo]()
$230
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/229:47 pm
BUF
- CLT
1 stop10h 11m
Multiple Airlines
Fri 3/2711:12 am
CLT
- BUF
1 stop9h 18m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$239
This JetBlue deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2610:25 am
BUF
- SAV
1 stop5h 57m
JetBlue
Mon 3/25:25 pm
SAV
- BUF
1 stop6h 07m
JetBlue
Deal found 1/28![JetBlue logo]()
$225
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/287:51 pm
BUF
- SAV
1 stop4h 08m
American Airlines
Wed 4/16:25 am
SAV
- BUF
1 stop4h 33m
American Airlines
Deal found 1/29![American Airlines logo]()
$251
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:08 pm
BUF
- SAV
1 stop5h 48m
Delta
Wed 4/156:50 am
SAV
- BUF
1 stop4h 11m
Delta
Deal found 1/28![Delta logo]()
$231
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/119:55 am
BUF
- CHS
1 stop4h 53m
United Airlines
Sat 2/147:47 pm
CHS
- BUF
1 stop3h 57m
United Airlines
Deal found 1/28![United Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/21:48 pm
BUF
- CLT
2 stops24h 03m
Multiple Airlines
Sun 3/87:48 pm
CLT
- BUF
1 stop15h 01m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$254
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:08 pm
BUF
- SAV
1 stop5h 48m
Delta
Sat 4/185:35 am
SAV
- BUF
1 stop5h 26m
Delta
Deal found 1/28![Delta logo]()
$231
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/33:45 pm
BUF
- GSP
1 stop4h 05m
Southwest
Thu 3/58:00 am
GSP
- BUF
1 stop3h 40m
Southwest
Deal found 1/27![Southwest logo]()
$287
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/204:25 pm
BUF
- SAV
2 stops7h 32m
American Airlines
Thu 2/265:00 am
SAV
- BUF
2 stops7h 14m
American Airlines
Deal found 1/28![American Airlines logo]()
$262
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/281:21 pm
BUF
- CHS
1 stop6h 19m
Delta
Tue 3/36:30 am
CHS
- BUF
1 stop4h 30m
Delta
Deal found 1/28![Delta logo]()
$234
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:07 am
BUF
- SAV
2 stops8h 31m
United Airlines
Sat 3/77:20 pm
SAV
- BUF
1 stop4h 22m
United Airlines
Deal found 1/29![United Airlines logo]()
$266
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/132:15 pm
BUF
- SAV
2 stops6h 23m
American Airlines
Tue 3/176:25 am
SAV
- BUF
1 stop4h 33m
American Airlines
Deal found 1/28![American Airlines logo]()
$273
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:03 pm
BUF
- CHS
1 stop4h 48m
United Airlines
Thu 6/117:45 pm
CHS
- BUF
1 stop4h 07m
United Airlines
Deal found 1/28![United Airlines logo]()
$271
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:28 pm
BUF
- CHS
1 stop4h 31m
American Airlines
Sat 4/255:02 am
CHS
- BUF
2 stops6h 56m
American Airlines
Deal found 1/29![American Airlines logo]()
$275
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:37 pm
BUF
- SAV
1 stop4h 22m
Delta
Tue 4/287:00 am
SAV
- BUF
1 stop7h 52m
Delta
Deal found 1/28![Delta logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/169:25 pm
BUF
- MYR
1 stop13h 40m
Multiple Airlines
Wed 3/186:28 pm
MYR
- BUF
2 stops17h 37m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$304
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/257:30 am
BUF
- GSP
2 stops12h 20m
Southwest
Wed 3/411:15 am
GSP
- BUF
2 stops11h 05m
Southwest
Deal found 1/28![Southwest logo]()
$338
This Kiwi.com deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/209:25 pm
BUF
- CLT
1 stop11h 35m
Multiple Airlines
Wed 3/259:00 pm
CLT
- BUF
2 stops37h 49m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$304
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/282:08 pm
BUF
- CHS
1 stop5h 48m
Delta
Mon 3/26:59 pm
CHS
- BUF
1 stop14h 49m
Delta
Deal found 1/28![Delta logo]()
$252
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/1312:30 pm
BUF
- GSP
1 stop5h 15m
Southwest
Tue 3/171:50 pm
GSP
- BUF
1 stop5h 30m
Southwest
Deal found 1/28![Southwest logo]()
$339
Last-minute flights from Buffalo to South CarolinaDiscover last-minute flight deals from Buffalo to South Carolina. Data last updated January 30, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated January 30, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/81:39 pm
BUF
- CLT
2 stops27h 57m
Multiple Airlines
Wed 2/116:01 pm
CLT
- BUF
1 stop17h 33m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$218
This CheapOair deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/97:31 pm
BUF
- CLT
1 stop18h 20m
Frontier
Sat 2/1410:16 am
CLT
- BUF
1 stop7h 29m
Frontier
Deal found 1/28![Frontier logo]()
$242
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/119:55 am
BUF
- CHS
1 stop4h 53m
United Airlines
Sat 2/147:47 pm
CHS
- BUF
1 stop3h 57m
United Airlines
Deal found 1/28![United Airlines logo]()
$240
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/207:45 pm
BUF
- SAV
1 stop4h 12m
American Airlines
Thu 2/266:25 am
SAV
- BUF
1 stop4h 28m
American Airlines
Deal found 1/28![American Airlines logo]()
$203
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/235:29 pm
BUF
- CHS
1 stop4h 19m
American Airlines
Mon 3/26:36 pm
CHS
- BUF
1 stop4h 13m
American Airlines
Deal found 1/27![American Airlines logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2311:17 am
BUF
- MYR
1 stop24h 27m
Multiple Airlines
Sat 2/289:09 am
MYR
- BUF
2 stops28h 15m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$230
This JetBlue deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2610:25 am
BUF
- SAV
1 stop5h 57m
JetBlue
Mon 3/25:25 pm
SAV
- BUF
1 stop6h 07m
JetBlue
Deal found 1/27![JetBlue logo]()
$217
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:41 pm
BUF
- SAV
1 stop4h 16m
American Airlines
Mon 3/26:09 pm
SAV
- BUF
1 stop5h 41m
American Airlines
Deal found 1/29![American Airlines logo]()
$239
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/277:41 pm
BUF
- CHS
1 stop15h 37m
Delta
Tue 3/31:04 pm
CHS
- BUF
1 stop4h 27m
Delta
Deal found 1/28![Delta logo]()
$235
This JetBlue deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2810:25 am
BUF
- SAV
1 stop5h 57m
JetBlue
Thu 3/55:21 pm
SAV
- BUF
1 stop6h 11m
JetBlue
Deal found 1/28![JetBlue logo]()
$189
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/284:25 pm
BUF
- SAV
2 stops7h 33m
American Airlines
Thu 3/56:09 pm
SAV
- BUF
1 stop5h 41m
American Airlines
Deal found 1/29![American Airlines logo]()
$208
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/281:21 pm
BUF
- CHS
1 stop6h 19m
Delta
Tue 3/36:30 am
CHS
- BUF
1 stop4h 30m
Delta
Deal found 1/28![Delta logo]()
$234
One-way flights from Buffalo to South CarolinaSearch for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated January 30, 2026.
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated January 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/37:17 pm
BUF
- CLT
1 stop18h 34m
Frontier
Deal found 1/30![Frontier logo]()
$67
This Frontier deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1311:02 am
BUF
- CLT
1 stop5h 53m
Frontier
Deal found 1/28![Frontier logo]()
$90
This Priceline deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1010:35 am
BUF
- SAV
1 stop5h 50m
JetBlue
Deal found 1/29![JetBlue logo]()
$91
This JetBlue deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:00 am
BUF
- CHS
1 stop4h 44m
JetBlue
Deal found 1/27![JetBlue logo]()
$99
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:30 am
BUF
- CHS
1 stop6h 08m
American Airlines
Deal found 1/28![American Airlines logo]()
$101
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2512:43 pm
BUF
- SAV
1 stop7h 17m
American Airlines
Deal found 1/29![American Airlines logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2812:00 pm
BUF
- CLT
2 stops26h 54m
Frontier
Deal found 1/27![Frontier logo]()
$105
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/104:04 pm
BUF
- SAV
2 stops6h 50m
American Airlines
Deal found 1/29![American Airlines logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/21:48 pm
BUF
- CLT
2 stops24h 03m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/37:17 pm
BUF
- CLT
2 stops18h 26m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$110
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:40 pm
BUF
- CHS
1 stop4h 17m
Delta
Deal found 1/28![Delta logo]()
$111
This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/67:48 pm
BUF
- SAV
1 stop4h 08m
Delta
Deal found 1/28![Delta logo]()
$112
Find flight deals from Buffalo to South Carolina
Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated January 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $151 (Kiwi.com) |
One-way from | $67 (Kiwi.com) |
Popular in | April |
Cheapest in | September |
Average price | $402 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 30, 2026.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.
Fly from
Buffalo
Fly to
South Carolina
Route
Depart
Return
Price
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Sat 2/28
10:25 am-4:22 pm
1 stop5h 57m
Savannah/Hilton Head
Thu 3/5
5:21 pm-11:32 pm
1 stop6h 11m
$197
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 4/24
4:44 pm-9:55 pm
1 stop5h 11m
Charleston
Tue 4/28
5:47 pm-12:49 am
1 stop7h 02m
$201
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 7/10
6:45 pm-11:20 pm
1 stop4h 35m
Charleston
Tue 7/14
11:55 am-4:47 pm
1 stop4h 52m
$201
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Sun 4/5
7:40 pm-11:55 pm
1 stop4h 15m
Charleston
Wed 4/8
6:06 am-11:14 am
1 stop5h 08m
$219
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 5/29
12:25 pm-7:05 pm
1 stop6h 40m
Charleston
Mon 6/1
3:30 pm-11:55 pm
1 stop8h 25m
$220
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Sat 4/18
1:35 pm-7:08 pm
1 stop5h 33m
Charleston
Sat 4/25
5:20 am-11:01 am
1 stop5h 41m
$221
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Thu 2/26
10:25 am-4:22 pm
1 stop5h 57m
Savannah/Hilton Head
Mon 3/2
5:25 pm-11:32 pm
1 stop6h 07m
$225
BuffaloMyrtle Beach
BUF - MYR
BUFMYR
Buffalo
Sat 3/7
11:44 am-8:50 am
1 stop21h 06m
Myrtle Beach Intl
Wed 3/11
9:09 am-10:49 am
2 stops25h 40m
$228
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Sat 4/11
7:45 pm-11:59 pm
1 stop4h 14m
Savannah/Hilton Head
Wed 4/15
9:15 am-5:10 pm
1 stop7h 55m
$230
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Sat 4/11
6:08 pm-11:56 pm
1 stop5h 48m
Savannah/Hilton Head
Wed 4/15
6:50 am-11:01 am
1 stop4h 11m
$231
Showing 1-10 of 60 results
Best time to book a flight from Buffalo to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
BUF-SAV
BUF-CHS
BUF-MYR
BUF-CLT
BUF-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to South Carolina
BUF-USSC
BUF-SAV
BUF-CHS
BUF-MYR
BUF-CLT
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $47). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $120). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from BUF to SC?
Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 30, 2026.
One of the essential ways to save on airfare from Buffalo to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 46% on airfare.
What is the cheapest day to fly from Buffalo to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Buffalo to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Buffalo to South Carolina flight should consider departing on Sunday at noon when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 30, 2026.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Overall
8.0
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Overall
8.0
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Overall
8.0
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Overall
8.0
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Overall
8.0
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes for Buffalo to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Top 5 airlines flying from Buffalo to South Carolina
Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$80 | Average$232 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$114 | Average$309 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$198 | Average$334 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$200 | Average$397 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$251 | Average$396 | FlexibilityNo cancel fee | On-time63% |