$90+ Cheap flights from Buffalo (BUF) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
Apr 17 — Apr 241
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 18, 2026.
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 18, 2026.
This Frontier deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/133:00 pm
BUF
- CLT
1 stop9h 36m
Frontier
Thu 4/169:31 am
CLT
- BUF
1 stop9h 42m
Frontier
Deal found 3/16![Frontier logo]()
$201
This Expedia deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/128:59 pm
BUF
- CLT
1 stop27h 37m
Frontier
Thu 4/166:35 pm
CLT
- BUF
1 stop15h 22m
Frontier
Deal found 3/17![Frontier logo]()
$225
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/56:19 am
BUF
- CLT
Nonstop2h 06m
American Airlines
Sun 4/511:06 am
CLT
- BUF
1 stop9h 23m
American Airlines
Deal found 3/14![American Airlines logo]()
$227
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:49 am
BUF
- CLT
1 stop7h 55m
American Airlines
Fri 5/110:00 pm
CLT
- BUF
Nonstop1h 47m
American Airlines
Deal found 3/14![American Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:16 pm
BUF
- CLT
1 stop13h 02m
Multiple Airlines
Mon 4/202:28 pm
CLT
- BUF
2 stops46h 14m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:31 pm
BUF
- CHS
1 stop14h 27m
Multiple Airlines
Sat 5/166:18 pm
CHS
- BUF
2 stops16h 23m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/811:12 am
BUF
- CLT
1 stop20h 28m
Frontier
Tue 4/145:30 pm
CLT
- BUF
2 stops19h 22m
Frontier
Deal found 3/16![Frontier logo]()
$246
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:08 pm
BUF
- SAV
1 stop5h 48m
Delta
Sat 4/185:35 am
SAV
- BUF
1 stop5h 26m
Delta
Deal found 3/18![Delta logo]()
$251
This Expedia deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:28 pm
BUF
- CHS
1 stop6h 54m
JetBlue
Sun 5/36:00 am
CHS
- BUF
1 stop7h 33m
JetBlue
Deal found 3/17![JetBlue logo]()
$251
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:00 pm
BUF
- CHS
1 stop4h 00m
Southwest
Wed 4/227:40 am
CHS
- BUF
1 stop4h 35m
Southwest
Deal found 3/13![Southwest logo]()
$255
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:42 pm
BUF
- SAV
2 stops6h 16m
American Airlines
Sat 4/186:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 3/16![American Airlines logo]()
$256
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1812:29 pm
BUF
- CHS
1 stop6h 35m
American Airlines
Sat 4/254:30 pm
CHS
- BUF
1 stop7h 19m
American Airlines
Deal found 3/14![American Airlines logo]()
$256
Best flights from Buffalo to South CarolinaDiscover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 18, 2026.
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 18, 2026.
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:00 pm
BUF
- SAV
1 stop4h 05m
Southwest
Thu 5/72:05 pm
SAV
- BUF
1 stop5h 40m
Southwest
Deal found 3/16![Southwest logo]()
$251
This JetBlue deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/212:25 pm
BUF
- CHS
1 stop4h 32m
JetBlue
Tue 5/56:00 am
CHS
- BUF
1 stop7h 33m
JetBlue
Deal found 3/17![JetBlue logo]()
$251
This United Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1410:35 am
BUF
- SAV
2 stops8h 40m
United Airlines
Mon 4/205:45 am
SAV
- BUF
1 stop4h 15m
United Airlines
Deal found 3/16![United Airlines logo]()
$262
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:40 pm
BUF
- CHS
1 stop4h 17m
Delta
Sun 6/215:30 am
CHS
- BUF
1 stop5h 45m
Delta
Deal found 3/14![Delta logo]()
$273
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/211:43 pm
BUF
- HHH
1 stop4h 02m
American Airlines
Sat 8/296:15 pm
HHH
- BUF
1 stop5h 54m
American Airlines
Deal found 3/17![American Airlines logo]()
$406
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/114:00 pm
BUF
- CHS
1 stop5h 30m
Southwest
Sat 5/168:00 am
CHS
- BUF
1 stop10h 00m
Southwest
Deal found 3/17![Southwest logo]()
$262
This United Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:00 am
BUF
- SAV
2 stops11h 15m
United Airlines
Sun 4/195:40 am
SAV
- BUF
1 stop4h 20m
United Airlines
Deal found 3/18![United Airlines logo]()
$286
This Delta deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:39 pm
BUF
- CHS
1 stop4h 20m
Delta
Mon 6/16:03 pm
CHS
- BUF
1 stop5h 56m
Delta
Deal found 3/17![Delta logo]()
$297
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/269:25 am
BUF
- GSP
1 stop6h 55m
Southwest
Wed 6/38:20 am
GSP
- BUF
1 stop6h 15m
Southwest
Deal found 3/18![Southwest logo]()
$271
This United Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:00 am
BUF
- SAV
2 stops11h 15m
United Airlines
Fri 4/105:45 am
SAV
- BUF
1 stop4h 15m
United Airlines
Deal found 3/13![United Airlines logo]()
$293
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/221:10 pm
BUF
- GSP
2 stops8h 30m
Southwest
Sat 4/258:00 am
GSP
- BUF
2 stops10h 00m
Southwest
Deal found 3/17![Southwest logo]()
$291
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:00 am
BUF
- HHH
2 stops8h 20m
Delta
Tue 8/184:00 pm
HHH
- BUF
1 stop7h 00m
Delta
Deal found 3/14![Delta logo]()
$322
This United Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:00 am
BUF
- CHS
1 stop4h 22m
United Airlines
Wed 8/128:55 am
CHS
- BUF
2 stops9h 59m
United Airlines
Deal found 3/15![United Airlines logo]()
$300
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:00 pm
BUF
- CHS
1 stop5h 30m
Southwest
Wed 4/297:15 am
CHS
- BUF
2 stops7h 20m
Southwest
Deal found 3/16![Southwest logo]()
$292
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:00 pm
BUF
- GSP
1 stop4h 35m
Southwest
Sat 4/188:00 am
GSP
- BUF
2 stops10h 00m
Southwest
Deal found 3/14![Southwest logo]()
$296
This United Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:50 pm
BUF
- CHS
1 stop4h 09m
United Airlines
Tue 5/59:40 am
CHS
- BUF
1 stop7h 14m
United Airlines
Deal found 3/14![United Airlines logo]()
$327
This Delta deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/133:33 pm
BUF
- CAE
1 stop6h 14m
Delta
Mon 4/204:30 pm
CAE
- BUF
1 stop7h 01m
Delta
Deal found 3/16![Delta logo]()
$364
This United Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/910:34 am
BUF
- CAE
1 stop3h 42m
United Airlines
Mon 7/137:45 pm
CAE
- BUF
1 stop4h 14m
United Airlines
Deal found 3/13![United Airlines logo]()
$329
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1312:40 pm
BUF
- SAV
2 stops8h 35m
Southwest
Mon 4/207:00 pm
SAV
- BUF
1 stop4h 20m
Southwest
Deal found 3/14![Southwest logo]()
$300
This Delta deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:42 pm
BUF
- GSP
1 stop5h 12m
Delta
Fri 4/106:14 pm
GSP
- BUF
1 stop4h 41m
Delta
Deal found 3/13![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1112:29 pm
BUF
- FLO
2 stops9h 18m
American Airlines
Tue 4/144:02 pm
FLO
- BUF
1 stop6h 38m
American Airlines
Deal found 3/17![American Airlines logo]()
$534
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1011:00 am
BUF
- CHS
2 stops9h 25m
Southwest
Mon 6/157:35 pm
CHS
- BUF
1 stop4h 35m
Southwest
Deal found 3/17![Southwest logo]()
$302
This Delta deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/179:00 am
BUF
- CLT
1 stop6h 47m
Delta
Sun 6/216:00 am
CLT
- BUF
1 stop5h 40m
Delta
Deal found 3/13![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:00 am
BUF
- GSP
1 stop5h 14m
United Airlines
Tue 5/56:27 pm
GSP
- BUF
1 stop5h 06m
United Airlines
Deal found 3/16![United Airlines logo]()
$351
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1310:00 am
BUF
- CLT
1 stop6h 18m
Delta
Mon 5/186:05 am
CLT
- BUF
1 stop5h 19m
Delta
Deal found 3/14![Delta logo]()
$369
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:05 am
BUF
- CLT
1 stop4h 30m
Southwest
Wed 6/38:00 am
CLT
- BUF
1 stop6h 35m
Southwest
Deal found 3/16![Southwest logo]()
$305
This United Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/137:00 am
BUF
- MYR
1 stop7h 17m
United Airlines
Mon 4/203:15 pm
MYR
- BUF
1 stop5h 28m
United Airlines
Deal found 3/16![United Airlines logo]()
$353
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:05 am
BUF
- MYR
1 stop4h 30m
Southwest
Mon 6/88:10 pm
MYR
- BUF
1 stop4h 00m
Southwest
Deal found 3/17![Southwest logo]()
$326
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:00 am
BUF
- CLT
1 stop6h 28m
Delta
Sun 5/176:05 am
CLT
- BUF
1 stop5h 19m
Delta
Deal found 3/14![Delta logo]()
$397
This United Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:09 am
BUF
- MYR
2 stops8h 08m
United Airlines
Tue 4/2811:00 am
MYR
- BUF
2 stops12h 33m
United Airlines
Deal found 3/15![United Airlines logo]()
$364
Last-minute flights from Buffalo to South CarolinaDiscover last-minute flight deals from Buffalo to South Carolina. Data last updated March 18, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated March 18, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/56:19 am
BUF
- CLT
Nonstop2h 06m
American Airlines
Sun 4/511:06 am
CLT
- BUF
1 stop9h 23m
American Airlines
Deal found 3/14![American Airlines logo]()
$227
This United Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:45 pm
BUF
- SAV
1 stop4h 14m
United Airlines
Fri 4/105:45 am
SAV
- BUF
1 stop4h 15m
United Airlines
Deal found 3/13![United Airlines logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/811:12 am
BUF
- CLT
1 stop20h 28m
Frontier
Tue 4/145:30 pm
CLT
- BUF
2 stops19h 22m
Frontier
Deal found 3/16![Frontier logo]()
$246
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:08 pm
BUF
- SAV
1 stop5h 48m
Delta
Sat 4/185:35 am
SAV
- BUF
1 stop5h 26m
Delta
Deal found 3/18![Delta logo]()
$251
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:42 pm
BUF
- SAV
2 stops6h 16m
American Airlines
Sat 4/186:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 3/16![American Airlines logo]()
$256
This Expedia deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/128:59 pm
BUF
- CLT
1 stop27h 37m
Frontier
Thu 4/166:35 pm
CLT
- BUF
1 stop15h 22m
Frontier
Deal found 3/17![Frontier logo]()
$225
This Frontier deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/133:00 pm
BUF
- CLT
1 stop9h 36m
Frontier
Thu 4/169:31 am
CLT
- BUF
1 stop9h 42m
Frontier
Deal found 3/16![Frontier logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:16 pm
BUF
- CLT
1 stop13h 02m
Multiple Airlines
Mon 4/202:28 pm
CLT
- BUF
2 stops46h 14m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$240
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:00 pm
BUF
- CHS
1 stop4h 00m
Southwest
Wed 4/227:40 am
CHS
- BUF
1 stop4h 35m
Southwest
Deal found 3/13![Southwest logo]()
$255
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1812:29 pm
BUF
- CHS
1 stop6h 35m
American Airlines
Sat 4/254:30 pm
CHS
- BUF
1 stop7h 19m
American Airlines
Deal found 3/14![American Airlines logo]()
$256
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:28 pm
BUF
- CHS
1 stop4h 31m
American Airlines
Wed 4/294:46 pm
CHS
- BUF
1 stop7h 01m
American Airlines
Deal found 3/17![American Airlines logo]()
$257
This Expedia deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:28 pm
BUF
- CHS
1 stop6h 54m
JetBlue
Sun 5/36:00 am
CHS
- BUF
1 stop7h 33m
JetBlue
Deal found 3/17![JetBlue logo]()
$251
One-way flights from Buffalo to South CarolinaSearch for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 18, 2026.
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 18, 2026.
This Frontier deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1311:02 am
BUF
- CLT
1 stop5h 53m
Frontier
Deal found 3/13![Frontier logo]()
$90
This Expedia deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/124:49 pm
BUF
- CLT
1 stop24h 06m
Frontier
Deal found 3/13![Frontier logo]()
$96
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:16 pm
BUF
- CLT
1 stop25h 47m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:16 pm
BUF
- CHS
1 stop12h 22m
Multiple Airlines
Deal found 3/14![Multiple Airlines logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/141:56 pm
BUF
- CLT
2 stops29h 18m
Frontier
Deal found 3/13![Frontier logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/151:56 pm
BUF
- CLT
2 stops18h 37m
Frontier
Deal found 3/13![Frontier logo]()
$118
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/275:45 am
BUF
- CHS
1 stop4h 30m
Southwest
Deal found 3/13![Southwest logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/178:49 pm
BUF
- CLT
1 stop27h 10m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$120
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/912:41 pm
BUF
- CLT
2 stops23h 24m
Frontier
Deal found 3/13![Frontier logo]()
$121
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2712:32 pm
BUF
- CLT
2 stops28h 03m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$122
This CheapOair deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:49 pm
BUF
- CLT
1 stop19h 54m
Frontier
Deal found 3/16![Frontier logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/312:32 pm
BUF
- CLT
2 stops45h 30m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$124
Find flight deals from Buffalo to South Carolina
Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated March 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $201 (Frontier) |
One-way from | $90 (Frontier) |
Popular in | March |
Cheapest in | September |
Average price | $445 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 18, 2026.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Sat 5/2
5:00 pm-9:05 pm
1 stop4h 05m
Savannah/Hilton Head
Thu 5/7
2:05 pm-7:45 pm
1 stop5h 40m
$251
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Sat 5/2
12:25 pm-4:57 pm
1 stop4h 32m
Charleston
Tue 5/5
6:00 am-1:33 pm
1 stop7h 33m
$251
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Tue 4/14
10:35 am-7:15 pm
2 stops8h 40m
Savannah/Hilton Head
Mon 4/20
5:45 am-10:00 am
1 stop4h 15m
$262
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Mon 5/11
4:00 pm-9:30 pm
1 stop5h 30m
Charleston
Sat 5/16
8:00 am-6:00 pm
1 stop10h 00m
$262
BuffaloGreenville
BUF - GSP
BUFGSP
Buffalo
Tue 5/26
9:25 am-4:20 pm
1 stop6h 55m
Greenville
Wed 6/3
8:20 am-2:35 pm
1 stop6h 15m
$271
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Thu 6/18
7:40 pm-11:57 pm
1 stop4h 17m
Charleston
Sun 6/21
5:30 am-11:15 am
1 stop5h 45m
$273
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Wed 4/15
7:00 am-6:15 pm
2 stops11h 15m
Savannah/Hilton Head
Sun 4/19
5:40 am-10:00 am
1 stop4h 20m
$286
BuffaloGreenville
BUF - GSP
BUFGSP
Buffalo
Wed 4/22
1:10 pm-9:40 pm
2 stops8h 30m
Greenville
Sat 4/25
8:00 am-6:00 pm
2 stops10h 00m
$291
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 4/24
4:00 pm-9:30 pm
1 stop5h 30m
Charleston
Wed 4/29
7:15 am-2:35 pm
2 stops7h 20m
$292
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Tue 4/7
7:00 am-6:15 pm
2 stops11h 15m
Savannah/Hilton Head
Fri 4/10
5:45 am-10:00 am
1 stop4h 15m
$293
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Buffalo to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
BUF-CLT
BUF-CHS
BUF-SAV
BUF-GSP
BUF-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to South Carolina
BUF-USSC
BUF-CLT
BUF-CHS
BUF-SAV
BUF-GSP
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $48). Flying from Buffalo to South Carolina in August is currently the most expensive (average of $118). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from BUF to SC?
Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 18, 2026.
One of the essential ways to save on airfare from Buffalo to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 46% on airfare.
What is the cheapest day to fly from Buffalo to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Buffalo to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Buffalo to South Carolina flight should consider departing on Sunday at noon when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 18, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Overall
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Overall
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Overall
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Overall
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Overall
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Comfort
8.0
Food
7.0
Boarding
8.1
Overall
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Related info for your journey
Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Buffalo and South Carolina flights
Browse other Buffalo and South Carolina flight options. Last updated on March 18, 2026.
Popular flight searches
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Buffalo to South Carolina flights
Consider these flights traveling from Buffalo to South Carolina.
Top 5 airlines flying from Buffalo to South Carolina
Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$80 | Average$232 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$108 | Average$315 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$198 | Average$343 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$200 | Average$332 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$236 | Average$410 | FlexibilityNo cancel fee | On-time63% |