How long is the flight from Buffalo to South Carolina?

Airlines like JetBlue, United Airlines, and American Airlines fly from Buffalo to South Carolina in about 4h 52m. The time it takes to get you to your destination can typically vary by up to 31m. The distance between Buffalo and South Carolina is about 759 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines to fly from Buffalo to South Carolina one-way?

The cheapest airlines for a one-way flight from Buffalo to South Carolina are American Airlines ($99), JetBlue ($100), and Delta ($113).

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

What are the most popular routes from Buffalo to South Carolina?

While some choose either Buffalo - Myrtle Beach Intl or Buffalo - Savannah/Hilton Head, Buffalo - Charlotte Douglas is the most popular route from Buffalo to South Carolina.

What are the most popular airlines that fly from Buffalo to South Carolina?

Consider American Airlines, Southwest or Delta when booking your flight. These represent the most popular airlines when flying from Buffalo to South Carolina.

What airport do you fly from for flights from Buffalo to South Carolina?

Buffalo (BUF) is the airport you will fly out of if you book a flight from Buffalo to South Carolina. It is only a 8.3 mi journey to Buffalo (BUF) from Buffalo’s city center.

Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Buffalo to South Carolina?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.

Can I find deals for business class flights from Buffalo to South Carolina?

Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$95+ Flights from Buffalo to South Carolina

Q: How much does it cost to fly round-trip from Buffalo to South Carolina?

Airfare is below average for this route at the moment. Buffalo to South Carolina flights typically cost between $200 and $457 in January. The cheapest round-trip price found within the last 3 days was $199 on American Airlines (Jan 11-Jan 17).

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Cheap flight deals from Buffalo to South Carolina

Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 16, 2025.

sáb. 12/209:28 amBUF - CLT

1 stop10h 41mFrontier

mié. 12/249:04 pmCLT - BUF

1 stop16h 08mFrontier

Deal found 12/16

$250

jue. 12/256:00 amBUF - MYR

1 stop4h 26mDelta

mié. 12/315:12 pmMYR - BUF

1 stop6h 25mDelta

Deal found 12/14

$255

sáb. 12/209:28 amBUF - CLT

1 stop5h 33mFrontier

lun. 12/222:51 pmCLT - BUF

1 stop6h 17mFrontier

Deal found 12/15

$264

lun. 12/2210:43 amBUF - CLT

1 stop10h 15mFrontier

mié. 12/249:04 pmCLT - BUF

1 stop16h 08mFrontier

Deal found 12/16

$271

jue. 12/256:00 amBUF - CHS

1 stop4h 41mAmerican Airlines

sáb. 1/38:08 pmCHS - BUF

1 stop4h 04mAmerican Airlines

Deal found 12/15

$290

sáb. 12/209:28 amBUF - CLT

1 stop5h 33mFrontier

lun. 1/52:51 pmCLT - BUF

1 stop6h 17mFrontier

Deal found 12/15

$294

sáb. 12/209:28 amBUF - CLT

1 stop10h 41mFrontier

vie. 1/22:51 pmCLT - BUF

1 stop5h 49mFrontier

Deal found 12/15

$299

jue. 12/252:50 pmBUF - CAE

1 stop4h 09mUnited Airlines

mié. 12/316:20 amCAE - BUF

1 stop7h 04mUnited Airlines

Deal found 12/14

$309

mié. 12/245:24 amBUF - SAV

1 stop5h 20mAmerican Airlines

jue. 1/16:22 amSAV - BUF

1 stop4h 45mAmerican Airlines

Deal found 12/14

$310

mar. 12/231:59 pmBUF - CHS

1 stop5h 19mUnited Airlines

mar. 12/306:05 amCHS - BUF

1 stop7h 19mUnited Airlines

Deal found 12/13

$310

vie. 12/199:42 amBUF - CLT

1 stop10h 27mFrontier

lun. 12/222:51 pmCLT - BUF

1 stop6h 17mFrontier

Deal found 12/15

$313

lun. 12/2210:43 amBUF - CLT

1 stop26h 54mMultiple Airlines

mié. 1/79:34 pmCLT - BUF

1 stop10h 39mMultiple Airlines

Deal found 12/15

$315

Best flights from Buffalo to South Carolina
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated diciembre 16, 2025.

jue. 1/159:55 amBUF - SAV

1 stop4h 52mUnited Airlines

jue. 1/229:45 amSAV - BUF

1 stop4h 29mUnited Airlines

Deal found 12/16

$200

sáb. 1/175:16 amBUF - SAV

1 stop5h 23mAmerican Airlines

lun. 1/196:00 amSAV - BUF

1 stop5h 21mAmerican Airlines

Deal found 12/15

$200

vie. 2/206:35 pmBUF - CHS

1 stop5h 21mDelta

dom. 3/15:27 amCHS - BUF

1 stop5h 51mDelta

Deal found 12/14

$201

jue. 1/297:59 pmBUF - CLT

1 stop13h 31mMultiple Airlines

dom. 2/19:19 pmCLT - BUF

2 stops15h 25mMultiple Airlines

Deal found 12/14

$233

jue. 1/12:07 pmBUF - CLT

1 stop23h 49mFrontier

jue. 1/158:46 pmCLT - BUF

1 stop23h 17mFrontier

Deal found 12/13

$264

lun. 1/123:45 pmBUF - GSP

1 stop4h 05mSouthwest

lun. 1/196:40 pmGSP - BUF

1 stop3h 50mSouthwest

Deal found 12/13

$303

mié. 1/146:32 pmBUF - SAV

1 stop4h 44mAmerican Airlines

dom. 1/186:15 amSAV - BUF

1 stop5h 53mAmerican Airlines

Deal found 12/15

$200

sáb. 2/212:08 pmBUF - CHS

1 stop6h 54mDelta

vie. 2/277:00 pmCHS - BUF

1 stop4h 31mDelta

Deal found 12/14

$201

mar. 2/101:59 pmBUF - SAV

1 stop7h 37mUnited Airlines

mar. 2/177:20 pmSAV - BUF

1 stop4h 24mUnited Airlines

Deal found 12/15

$203

sáb. 1/175:16 amBUF - SAV

1 stop5h 23mAmerican Airlines

mié. 1/216:15 amSAV - BUF

1 stop5h 53mAmerican Airlines

Deal found 12/16

$200

dom. 2/226:00 amBUF - CHS

1 stop4h 57mDelta

sáb. 2/288:30 amCHS - BUF

1 stop4h 33mDelta

Deal found 12/14

$201

jue. 1/228:30 amBUF - CHS

1 stop5h 32mUnited Airlines

dom. 1/256:05 amCHS - BUF

2 stops8h 09mUnited Airlines

Deal found 12/15

$206

jue. 1/296:49 pmBUF - CHS

1 stop5h 06mDelta

jue. 2/511:49 amCHS - BUF

1 stop5h 10mDelta

Deal found 12/15

$201

vie. 1/307:00 amBUF - SAV

1 stop7h 24mAmerican Airlines

dom. 2/16:15 amSAV - BUF

1 stop5h 53mAmerican Airlines

Deal found 12/15

$203

vie. 2/206:35 pmBUF - CHS

1 stop5h 21mDelta

sáb. 2/286:00 amCHS - BUF

1 stop5h 09mDelta

Deal found 12/14

$201

jue. 1/225:27 pmBUF - SAV

1 stop4h 07mAmerican Airlines

dom. 1/255:23 pmSAV - BUF

1 stop5h 32mAmerican Airlines

Deal found 12/16

$203

dom. 2/226:00 amBUF - CHS

1 stop4h 57mDelta

dom. 3/15:27 amCHS - BUF

1 stop5h 51mDelta

Deal found 12/14

$201

mié. 2/411:27 amBUF - CHS

1 stop5h 12mAmerican Airlines

sáb. 2/145:07 amCHS - BUF

2 stops6h 32mAmerican Airlines

Deal found 12/15

$206

vie. 2/206:35 pmBUF - CHS

1 stop5h 21mDelta

vie. 2/277:00 pmCHS - BUF

1 stop4h 31mDelta

Deal found 12/14

$201

mié. 1/1411:24 amBUF - CAE

2 stops9h 57mUnited Airlines

dom. 1/182:37 pmCAE - BUF

1 stop5h 52mUnited Airlines

Deal found 12/14

$274

sáb. 1/3111:50 amBUF - CHS

2 stops9h 21mAmerican Airlines

lun. 2/27:42 pmCHS - BUF

1 stop3h 59mAmerican Airlines

Deal found 12/16

$206

sáb. 2/283:38 pmBUF - SAV

1 stop5h 19mDelta

jue. 3/55:30 amSAV - BUF

1 stop5h 48mDelta

Deal found 12/16

$203

jue. 1/295:27 pmBUF - SAV

1 stop4h 07mAmerican Airlines

dom. 2/16:15 amSAV - BUF

2 stops5h 53mAmerican Airlines

Deal found 12/15

$208

mié. 4/11:20 pmBUF - GSP

2 stops9h 20mSouthwest

mar. 4/76:45 amGSP - BUF

2 stops7h 50mSouthwest

Deal found 12/14

$377

mar. 2/37:00 amBUF - SAV

1 stop4h 48mDelta

sáb. 2/76:50 amSAV - BUF

1 stop6h 19mDelta

Deal found 12/16

$203

dom. 1/116:05 amBUF - CHS

2 stops7h 34mAmerican Airlines

sáb. 1/1712:31 pmCHS - BUF

2 stops8h 45mAmerican Airlines

Deal found 12/16

$209

vie. 1/309:55 amBUF - CLT

1 stop4h 18mUnited Airlines

lun. 2/29:55 amCLT - BUF

1 stop4h 19mUnited Airlines

Deal found 12/15

$313

jue. 1/2912:14 pmBUF - SAV

1 stop4h 48mDelta

dom. 2/15:30 amSAV - BUF

1 stop5h 38mDelta

Deal found 12/16

$203

sáb. 1/312:49 pmBUF - CAE

1 stop4h 06mUnited Airlines

mar. 2/32:49 pmCAE - BUF

1 stop4h 36mUnited Airlines

Deal found 12/13

$339

sáb. 3/284:57 pmBUF - CHS

1 stop4h 18mDelta

jue. 4/25:20 amCHS - BUF

1 stop5h 41mDelta

Deal found 12/16

$234

Last-minute flights from Buffalo to South Carolina
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated diciembre 16, 2025 and is based on user searches.

lun. 1/510:43 amBUF - CLT

1 stop10h 15mFrontier

jue. 1/88:46 pmCLT - BUF

1 stop11h 27mFrontier

Deal found 12/15

$183

dom. 1/119:08 amBUF - CLT

1 stop23h 54mFrontier

sáb. 1/178:46 pmCLT - BUF

1 stop23h 17mFrontier

Deal found 12/14

$199

lun. 1/129:08 amBUF - CLT

1 stop7h 46mMultiple Airlines

mié. 1/146:00 amCLT - BUF

2 stops27h 21mMultiple Airlines

Deal found 12/16

$206

mié. 1/146:32 pmBUF - SAV

1 stop4h 44mAmerican Airlines

dom. 1/186:15 amSAV - BUF

1 stop5h 53mAmerican Airlines

Deal found 12/15

$200

sáb. 1/178:06 pmBUF - CLT

1 stop11h 57mFrontier

sáb. 1/249:59 pmCLT - BUF

1 stop12h 08mFrontier

Deal found 12/16

$164

sáb. 1/175:16 amBUF - SAV

2 stops9h 08mAmerican Airlines

mié. 1/216:15 amSAV - BUF

2 stops5h 53mAmerican Airlines

Deal found 12/16

$210

jue. 1/224:17 pmBUF - CHS

1 stop4h 55mAmerican Airlines

dom. 1/258:00 amCHS - BUF

1 stop4h 08mAmerican Airlines

Deal found 12/15

$201

jue. 1/228:30 amBUF - CHS

1 stop5h 32mUnited Airlines

dom. 1/256:05 amCHS - BUF

2 stops8h 09mUnited Airlines

Deal found 12/15

$206

jue. 1/297:59 pmBUF - CLT

1 stop13h 31mFrontier

jue. 2/59:58 pmCLT - BUF

1 stop20h 38mFrontier

Deal found 12/15

$181

jue. 1/2912:14 pmBUF - SAV

1 stop4h 48mDelta

dom. 2/15:30 amSAV - BUF

1 stop5h 38mDelta

Deal found 12/16

$203

jue. 1/291:39 pmBUF - CLT

2 stops19h 51mMultiple Airlines

jue. 2/511:12 amCLT - BUF

1 stop7h 52mMultiple Airlines

Deal found 12/15

$203

jue. 1/296:53 pmBUF - SAV

1 stop4h 23mAmerican Airlines

dom. 2/16:15 amSAV - BUF

2 stops5h 53mAmerican Airlines

Deal found 12/16

$208

One-way flights from Buffalo to South Carolina
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated diciembre 16, 2025.

lun. 1/129:08 amBUF - CLT

1 stop7h 46mMultiple Airlines

Deal found 12/15

$95

mié. 1/2811:27 amBUF - CHS

1 stop5h 12mAmerican Airlines

Deal found 12/14

$101

mié. 1/146:00 amBUF - SAV

1 stop7h 09mUnited Airlines

Deal found 12/15

$102

lun. 1/510:43 amBUF - CHS

1 stop21h 54mMultiple Airlines

Deal found 12/14

$102

dom. 1/119:08 amBUF - CLT

1 stop27h 43mFrontier

Deal found 12/15

$103

sáb. 1/178:06 pmBUF - CLT

1 stop11h 57mFrontier

Deal found 12/15

$106

mié. 1/146:00 amBUF - SAV

2 stops8h 24mAmerican Airlines

Deal found 12/15

$107

jue. 1/158:58 pmBUF - CLT

1 stop11h 05mFrontier

Deal found 12/16

$108

sáb. 1/106:33 pmBUF - CLT

1 stop15h 44mMultiple Airlines

Deal found 12/14

$114

dom. 1/41:37 pmBUF - CHS

1 stop19h 20mMultiple Airlines

Deal found 12/14

$118

mar. 2/1010:00 amBUF - MYR

1 stop11h 04mMultiple Airlines

Deal found 12/14

$121

vie. 1/1612:15 pmBUF - CLT

2 stops46h 46mFrontier

Deal found 12/14

$126

Find flight deals from Buffalo to South Carolina

Most accurate provider	Mytrip 3 stars
Most trusted provider	Mytrip 3 stars
Round-trip from	$164 (Frontier)
One-way from	$95 (Trip.com)
Popular in	April
Cheapest in	October
Average price	$386

Provider with most accurate pricing for Buffalo-Myrtle Beach Intl flight deals.

Search Deals

Provider most trusted by Cheapflights users for Buffalo-Myrtle Beach Intl flights.

Search Deals

From Buffalo to South Carolina

Search Deals

One-way flight from Buffalo to South Carolina

Search Deals

Highest demand for flights based on searches. 10% potential increase in price ($43 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

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Cheapflights Fare Finder

Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

jue. 1/15

9:55 am-2:47 pm

1 stop4h 52m

Savannah/Hilton Head

jue. 1/22

9:45 am-2:14 pm

1 stop4h 29m

$200

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

sáb. 1/17

5:16 am-10:39 am

1 stop5h 23m

Savannah/Hilton Head

lun. 1/19

6:00 am-11:21 am

1 stop5h 21m

$200

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

mié. 1/14

6:32 pm-11:16 pm

1 stop4h 44m

Savannah/Hilton Head

dom. 1/18

6:15 am-12:08 pm

1 stop5h 53m

$200

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

sáb. 1/17

5:16 am-10:39 am

1 stop5h 23m

Savannah/Hilton Head

mié. 1/21

6:15 am-12:08 pm

1 stop5h 53m

$200

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

vie. 2/20

6:35 pm-11:56 pm

1 stop5h 21m

Charleston

dom. 3/1

5:27 am-11:18 am

1 stop5h 51m

$201

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

sáb. 2/21

2:08 pm-9:02 pm

1 stop6h 54m

Charleston

vie. 2/27

7:00 pm-11:31 pm

1 stop4h 31m

$201

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

dom. 2/22

6:00 am-10:57 am

1 stop4h 57m

Charleston

sáb. 2/28

8:30 am-1:03 pm

1 stop4h 33m

$201

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

jue. 1/29

6:49 pm-11:55 pm

1 stop5h 06m

Charleston

jue. 2/5

11:49 am-4:59 pm

1 stop5h 10m

$201

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

vie. 2/20

6:35 pm-11:56 pm

1 stop5h 21m

Charleston

sáb. 2/28

6:00 am-11:09 am

1 stop5h 09m

$201

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

dom. 2/22

6:00 am-10:57 am

1 stop4h 57m

Charleston

dom. 3/1

5:27 am-11:18 am

1 stop5h 51m

$201

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Showing 1-10 of 60 results

...

Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $47). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $131). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to SC?

One of the essential ways to save on airfare from Buffalo to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 14% on airfare.

What is the cheapest day to fly from Buffalo to South Carolina?

Travelers seeking maximum savings on their Buffalo to South Carolina flight should consider departing on Sunday at noon when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Buffalo to South Carolina?

Reviews of airlines servicing South Carolina

Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Southwest

7.9

Good

4,250 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Delta

7.9

Good

8,008 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

United Airlines

7.4

Good

9,092 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

American Airlines

7.2

Good

11,049 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

JetBlue

7.2

Good

2,895 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

What airport do you fly from for flights from Buffalo to South Carolina?
Buffalo (BUF) is the airport you will fly out of if you book a flight from Buffalo to South Carolina. It is only a 8.3 mi journey to Buffalo (BUF) from Buffalo’s city center.
How long is the flight from Buffalo to South Carolina?
Airlines like JetBlue, United Airlines, and American Airlines fly from Buffalo to South Carolina in about 4h 52m. The time it takes to get you to your destination can typically vary by up to 31m. The distance between Buffalo and South Carolina is about 759 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines to fly from Buffalo to South Carolina one-way?
The cheapest airlines for a one-way flight from Buffalo to South Carolina are American Airlines ($99), JetBlue ($100), and Delta ($113).
What are the most popular routes from Buffalo to South Carolina?
While some choose either Buffalo - Myrtle Beach Intl or Buffalo - Savannah/Hilton Head, Buffalo - Charlotte Douglas is the most popular route from Buffalo to South Carolina.
Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?
Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Buffalo to South Carolina?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.
Can I find deals for business class flights from Buffalo to South Carolina?
Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $47). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $131). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

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Top 5 airlines flying from Buffalo to South Carolina

Airline	Cheapest	Average	Flexibility	On-time
JetBlue	Cheapest$180	Average$232	FlexibilityNo cancel fee	On-time62%
Delta	Cheapest$196	Average$305	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$198	Average$335	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$200	Average$390	FlexibilityNo cancel fee	On-time69%
Southwest	Cheapest$251	Average$403	FlexibilityNo cancel fee	On-time63%

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$95+ Cheap flights from Buffalo (BUF) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Buffalo to South Carolina

Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 16, 2025.

Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 16, 2025.

Find flight deals from Buffalo to South Carolina

Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated diciembre 16, 2025.

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Best time to book a flight from Buffalo to South Carolina

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What is the cheapest time of day to fly from BUF to SC?

Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 16, 2025.

What is the cheapest day to fly from Buffalo to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Buffalo to South Carolina. Price data was last updated on December 16, 2024.

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Reviews of airlines servicing South Carolina

Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

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Top 5 airlines flying from Buffalo to South Carolina

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Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 16, 2025.