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South Carolina

$108+ Cheap flights from Buffalo (BUF) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/17. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
Jul 8 — Jul 151
Tue 7/8
Tue 7/15
1 adult, Economy
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Cheap flight deals from Buffalo to South Carolina

Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated July 3, 2025.

Round-trip from

$161
(JetBlue)

One-way from

$108
(Mytrip)

Popular in

April

Cheapest in

September

Average price

$368
From Buffalo to South Carolina
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One-way flight from Buffalo to South Carolina
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Highest demand for flights based on searches. 8% potential increase in price ($34 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Buffalo to South Carolina

Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

This JetBlue deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/225:35 amBUF - CHS
1 stop4h 40mJetBlue
Tue 7/296:59 pmCHS - BUF
1 stop5h 00mJetBlue
Deal found 7/1$161
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2311:54 amBUF - SAV
1 stop5h 34mAmerican Airlines
Sat 8/306:25 amSAV - BUF
1 stop4h 39mAmerican Airlines
Deal found 7/3$208
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/313:34 pmBUF - MYR
1 stop3h 56mAmerican Airlines
Mon 11/35:36 amMYR - BUF
1 stop5h 02mAmerican Airlines
Deal found 7/3$218
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/291:46 pmBUF - CHS
1 stop5h 50mAmerican Airlines
Sun 8/316:00 amCHS - BUF
1 stop5h 04mAmerican Airlines
Deal found 7/3$218
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/217:15 pmBUF - SAV
1 stop4h 44mDelta
Sat 8/306:37 pmSAV - BUF
1 stop4h 22mDelta
Deal found 7/1$227
This FlightHub deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/56:59 pmBUF - CLT
1 stop18h 02mFrontier
Sun 9/78:44 pmCLT - BUF
1 stop21h 30mFrontier
Deal found 7/2$236
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/237:50 amBUF - GSP
1 stop4h 05mAmerican Airlines
Thu 10/26:05 amGSP - BUF
1 stop4h 25mAmerican Airlines
Deal found 7/1$237
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/147:15 pmBUF - MYR
1 stop4h 34mDelta
Wed 8/206:56 pmMYR - BUF
1 stop5h 01mDelta
Deal found 7/1$237
This Delta deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/237:45 pmBUF - CHS
1 stop4h 14mDelta
Sun 7/275:15 amCHS - BUF
1 stop5h 47mDelta
Deal found 7/3$237
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/205:50 amBUF - MYR
1 stop4h 05mSouthwest
Wed 8/276:30 amMYR - BUF
2 stops8h 45mSouthwest
Deal found 7/1$242
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/204:15 pmBUF - SAV
2 stops6h 40mSouthwest
Mon 10/275:35 amSAV - BUF
1 stop6h 35mSouthwest
Deal found 7/1$242
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/55:50 amBUF - CLT
1 stop4h 15mSouthwest
Tue 8/197:40 amCLT - BUF
2 stops8h 05mSouthwest
Deal found 6/30$242

Cheapflights Fare Finder

Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Buffalo

Fly to

South Carolina

Route

Depart

Return

Price

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Tue 7/22

5:35 am-10:15 am

1 stop4h 40m

Charleston

Tue 7/29

6:59 pm-11:59 pm

1 stop5h 00m

$161

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Sat 8/23

11:54 am-5:28 pm

1 stop5h 34m

Savannah/Hilton Head

Sat 8/30

6:25 am-11:04 am

1 stop4h 39m

$208

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Fri 8/29

1:46 pm-7:36 pm

1 stop5h 50m

Charleston

Sun 8/31

6:00 am-11:04 am

1 stop5h 04m

$218

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Thu 8/21

7:15 pm-11:59 pm

1 stop4h 44m

Savannah/Hilton Head

Sat 8/30

6:37 pm-10:59 pm

1 stop4h 22m

$227

BuffaloCharlotte

BUF - CLT

BUFCLT

Buffalo

Fri 9/5

6:59 pm-1:01 pm

1 stop18h 02m

Charlotte Douglas

Sun 9/7

8:44 pm-6:14 pm

1 stop21h 30m

$236

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Mon 10/20

5:45 pm-9:45 pm

1 stop4h 00m

Savannah/Hilton Head

Mon 10/27

5:35 am-12:10 pm

1 stop6h 35m

$237

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Thu 8/14

7:15 pm-11:49 pm

1 stop4h 34m

Myrtle Beach Intl

Wed 8/20

6:56 pm-11:57 pm

1 stop5h 01m

$237

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Tue 9/23

7:50 am-11:55 am

1 stop4h 05m

Greenville

Thu 10/2

6:05 am-10:30 am

1 stop4h 25m

$237

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Wed 7/23

7:45 pm-11:59 pm

1 stop4h 14m

Charleston

Sun 7/27

5:15 am-11:02 am

1 stop5h 47m

$237

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

Wed 8/20

5:50 am-9:55 am

1 stop4h 05m

Myrtle Beach Intl

Wed 8/27

6:30 am-3:15 pm

2 stops8h 45m

$242

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/2

Showing 1-10 of 59 results
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Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $217). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to SC?

Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 3, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Buffalo to South Carolina as you normally would.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated July 3, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,270 reviews

Entertainment

7.6

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.2

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,270 reviews
Southwest
8.0
Very good
4,270 reviews

Entertainment

7.6

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.2

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,970 reviews
Southwest
8.0
Very good
4,270 reviews

Entertainment

7.6

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.2

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,845 reviews
Southwest
8.0
Very good
4,270 reviews

Entertainment

7.6

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.2

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
JetBlue
7.3
Good
2,916 reviews
Southwest
8.0
Very good
4,270 reviews

Entertainment

7.6

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.2

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,270 reviews

Entertainment

7.6

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.2

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to South Carolina?

    Buffalo (BUF) is the airport you will fly out of if you book a flight from Buffalo to South Carolina. It is only a 8.3 mi journey to Buffalo (BUF) from Buffalo’s city center.

  • What are the cheapest airlines to fly from Buffalo to South Carolina one-way?

    The cheapest airlines for a one-way flight from Buffalo to South Carolina are Frontier ($108), American Airlines ($109), and Southwest ($124).

  • What are the most popular routes from Buffalo to South Carolina?

    While some choose either Buffalo - Myrtle Beach Intl or Buffalo - Charleston, Buffalo - Charlotte Douglas is the most popular route from Buffalo to South Carolina.

  • Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.

  • Can I find deals for business class flights from Buffalo to South Carolina?

    Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $217). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Buffalo to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Buffalo to South Carolina

Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$191Average$246FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$196Average$390FlexibilityNo cancel feeOn-time71%
DeltaCheapest$196Average$313FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$218Average$410FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$234Average$370FlexibilityNo cancel feeOn-time69%

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