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Sioux Falls

$130+ Cheap flights from Knoxville to Sioux Falls (TYS - FSD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/9. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — FSD
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Knoxville to Sioux Falls

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Sioux Falls (FSD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$259
(United Airlines)

One-way from

$130
(Kiwi.com)

Popular in

August

Cheapest in

January

Average price

$486
From Knoxville McGhee Tyson to Sioux Falls Joe Foss Field
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One-way flight from Knoxville McGhee Tyson to Sioux Falls Joe Foss Field
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Highest demand for flights based on searches. 13% potential increase in price ($72 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($26 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Sioux Falls

Cheapest flights from Knoxville to Sioux Falls
Explore the most affordable flight options available from Knoxville to Sioux Falls. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/265:53 pmTYS - FSD
1 stop5h 29mUnited Airlines
Tue 9/303:12 pmFSD - TYS
1 stop6h 38mUnited Airlines
Deal found 9/11$259
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/175:53 pmTYS - FSD
1 stop5h 29mUnited Airlines
Wed 10/223:12 pmFSD - TYS
1 stop6h 38mUnited Airlines
Deal found 9/10$319
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/104:37 pmTYS - FSD
1 stop5h 46mAmerican Airlines
Sun 9/145:19 pmFSD - TYS
1 stop5h 32mAmerican Airlines
Deal found 9/9$339
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/247:28 amTYS - FSD
1 stop6h 10mAmerican Airlines
Sun 9/287:00 amFSD - TYS
1 stop5h 09mAmerican Airlines
Deal found 9/9$377
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:04 pmTYS - FSD
1 stop5h 53mDelta
Tue 10/215:30 amFSD - TYS
1 stop7h 12mDelta
Deal found 9/10$393
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/206:45 amTYS - FSD
1 stop5h 07mUnited Airlines
Sat 1/36:16 pmFSD - TYS
1 stop21h 44mUnited Airlines
Deal found 9/10$403
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:04 pmTYS - FSD
1 stop5h 53mDelta
Wed 10/225:30 amFSD - TYS
1 stop4h 15mDelta
Deal found 9/11$409
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/168:17 pmTYS - FSD
1 stop23h 16mMultiple Airlines
Tue 10/211:29 pmFSD - TYS
2 stops24h 00mMultiple Airlines
Deal found 9/9$413

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Sioux Falls that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Knoxville to Sioux Falls that are best for you.

Fly from

Knoxville

Fly to

Sioux Falls

Route

Depart

Return

Price

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 9/26

5:53 pm-10:22 pm

1 stop5h 29m

Sioux Falls Joe Foss Field

Tue 9/30

3:12 pm-10:50 pm

1 stop6h 38m

$259

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 10/17

5:53 pm-10:22 pm

1 stop5h 29m

Sioux Falls Joe Foss Field

Wed 10/22

3:12 pm-10:50 pm

1 stop6h 38m

$319

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 9/26

5:45 am-1:51 pm

2 stops9h 06m

Sioux Falls Joe Foss Field

Tue 9/30

5:00 am-1:07 pm

2 stops7h 07m

$339

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Wed 9/24

7:28 am-12:38 pm

1 stop6h 10m

Sioux Falls Joe Foss Field

Sun 9/28

7:00 am-1:09 pm

1 stop5h 09m

$377

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 10/17

6:04 pm-10:57 pm

1 stop5h 53m

Sioux Falls Joe Foss Field

Tue 10/21

5:30 am-1:42 pm

1 stop7h 12m

$393

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 10/17

6:04 pm-10:57 pm

1 stop5h 53m

Sioux Falls Joe Foss Field

Wed 10/22

5:30 am-10:45 am

1 stop4h 15m

$399

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Thu 10/16

8:17 pm-6:33 pm

1 stop23h 16m

Sioux Falls Joe Foss Field

Tue 10/21

1:29 pm-2:29 pm

2 stops24h 00m

$413

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Thu 10/16

5:37 pm-10:42 pm

1 stop6h 05m

Sioux Falls Joe Foss Field

Tue 10/21

5:05 pm-12:23 am

1 stop6h 18m

$441

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Thu 10/9

8:17 pm-6:33 pm

1 stop23h 16m

$130

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Thu 10/9

3:32 pm-8:42 pm

2 stops30h 10m

$198

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Best time to book a flight from Knoxville to Sioux Falls

Have a flexible travel schedule? Discover the best time to fly to Sioux Falls from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Sioux Falls

What is the cheapest month to book a flight from Knoxville to Sioux Falls?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Sioux Falls (average of $334). Flying from Knoxville to Sioux Falls in December is currently the most expensive (average of $446). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to FSD?

Find hourly flight availability from Knoxville to Sioux Falls. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

One of the essential ways to save on airfare from Knoxville to Sioux Falls is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the morning could potentially save you up to 24% on airfare.

Reviews of airlines servicing Sioux Falls

Get insights into the airlines that provide service to Sioux Falls. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Sioux Falls. Reviews last updated September 11, 2025.
Get a feel of what it's like to fly with American Airlines from Knoxville to Sioux Falls by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Entertainment

6.9

Food

6.4

Boarding

7.5

Comfort

7.2

Overall

7.2

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Entertainment

6.9

Food

6.4

Boarding

7.5

Comfort

7.2

Overall

7.2

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Sioux Falls. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Sioux Falls?

    Departing from Knoxville to Sioux Falls will take you 5h 29m. The distance from Knoxville to Sioux Falls is about 863 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Knoxville to Sioux Falls round-trip?

    Flying on American Airlines is currently your cheapest option to Sioux Falls, with prices starting at $248. Users have found that American Airlines is 47% cheaper than the other options available to this destination.

  • Can I find deals for flights from Knoxville to Sioux Falls that include hotel bookings?

    Yes. In addition to deals on Knoxville to Sioux Falls flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Sioux Falls?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Sioux Falls.

  • Can I find deals for business class flights from Knoxville to Sioux Falls?

    Yes. Cheapflights offers flight deals from Knoxville to Sioux Falls by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Sioux Falls?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Sioux Falls (average of $334). Flying from Knoxville to Sioux Falls in December is currently the most expensive (average of $446). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Sioux Falls?

Book flights to Sioux Falls if you plan to visit one of these locations
Marshall

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Top airline flying from Knoxville to Sioux Falls

Discover the top airline that operate flights from Knoxville to Sioux Falls. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$443FlexibilityNo cancel feeOn-time71%

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