What are the cheapest airlines flying from Knoxville to Sioux Falls round-trip?

Flying on Frontier is currently your cheapest option to Sioux Falls, with prices starting at $225. Additional round-trip tickets that might be worth considering are offered by Delta and American Airlines, with the lowest prices starting at $254 and $366, respectively. Users have found that Frontier is 48% cheaper than the other options available to this destination.

What are the cheapest airlines to fly from Knoxville to Sioux Falls one-way?

The cheapest airlines for a one-way flight from Knoxville to Sioux Falls are Delta ($166), American Airlines ($327), and United Airlines ($507).

What is the cheapest day to fly from Knoxville to Sioux Falls?

Travelers seeking maximum savings on their Knoxville to Sioux Falls flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Thursday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Sioux Falls ranges from 0.6 - 3.9 inches per month. June is typically the wettest month, when rainfall can reach 3.9 in. January is typically the driest time to visit Sioux Falls when rainfall is around 0.6 in.

If weather is an important factor for your trip to Sioux Falls, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 15.8 F).

What is the cheapest day to fly round-trip from Knoxville to Sioux Falls?

Departing on a Thursday is a good option for securing a great price. You can expect to save up to 149% when planning your travel around this day of the week.

What is the cheapest month to fly from Knoxville to Sioux Falls?

January is one of the best times of the year to fly to Sioux Falls from Knoxville. Prices for January average $438 per person but you can even find prices for as low as $253. The most expensive prices can be found in the month of June. Opting for a January flight can save you 45% on your journey compared to booking in June

Can I find deals for flights from Knoxville to Sioux Falls that include hotel bookings?

Yes. In addition to deals on Knoxville to Sioux Falls flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Knoxville to Sioux Falls?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Sioux Falls.

Can I find deals for business class flights from Knoxville to Sioux Falls?

Yes. Cheapflights offers flight deals from Knoxville to Sioux Falls by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$160+ Flights from Knoxville to Sioux Falls

Q: How much does it cost to fly round-trip from Knoxville to Sioux Falls?

Airfare is below average for this route at the moment. Knoxville to Sioux Falls flights typically cost between $508 and $801 in September. The cheapest round-trip price found within the last 3 days was $225 on Frontier (Sep 11-Sep 14).

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Cheap flight deals from Knoxville to Sioux Falls

Round-trip from	$225 (FlightHub)
One-way from	$160 (Mytrip)
Popular in	June
Cheapest in	January
Average price	$443

From Knoxville McGhee Tyson to Sioux Falls Joe Foss Field

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One-way flight from Knoxville McGhee Tyson to Sioux Falls Joe Foss Field

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Highest demand for flights based on searches. 9% potential increase in price ($46 potential increase over avg. RT price).

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Cheapest flight prices on average. 5% potential price decrease ($23 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from Knoxville to Sioux Falls

Cheapest flights from Knoxville to Sioux Falls
Explore the most affordable flight options available from Knoxville to Sioux Falls. Find the lowest fares from popular airlines and budget airlines, with prices last updated on juli 29, 2025.

tors 9/118:40 pmTYS - FSD

1 stop18h 29mFrontier

sön 9/142:54 pmFSD - TYS

1 stop27h 51mFrontier

Deal found 7/27

$225

tors 9/116:00 pmTYS - FSD

1 stop5h 44mDelta

sön 9/145:00 amFSD - TYS

2 stops7h 07mDelta

Deal found 7/28

$254

tors 7/316:29 pmTYS - FSD

1 stop6h 30mAmerican Airlines

lör 8/24:29 pmFSD - TYS

1 stop5h 06mAmerican Airlines

Deal found 7/27

$339

mån 7/281:56 pmTYS - FSD

1 stop4h 48mUnited Airlines

tis 7/292:00 pmFSD - TYS

1 stop7h 22mUnited Airlines

Deal found 7/27

$477

tors 7/319:45 amTYS - FSD

3 stops34h 31mMultiple Airlines

lör 8/26:55 pmFSD - TYS

1 stop15h 26mMultiple Airlines

Deal found 7/27

$794

Best flights from Knoxville to Sioux Falls
Discover carefully curated flight deals from Knoxville to Sioux Falls that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated juli 29, 2025.

tors 9/118:40 pmTYS - FSD

1 stop18h 29mFrontier

sön 9/142:54 pmFSD - TYS

1 stop27h 51mFrontier

Deal found 7/27

$225

tors 9/116:00 pmTYS - FSD

1 stop5h 44mDelta

sön 9/145:00 amFSD - TYS

2 stops7h 07mDelta

Deal found 7/28

$254

mån 10/66:00 amTYS - FSD

1 stop7h 47mAmerican Airlines

sön 10/125:07 pmFSD - TYS

1 stop5h 44mAmerican Airlines

Deal found 7/29

$366

Last-minute flights from Knoxville to Sioux Falls
Discover last-minute flight deals from Knoxville to Sioux Falls. Data last updated juli 29, 2025 and is based on user searches.

tors 7/316:29 pmTYS - FSD

1 stop6h 30mAmerican Airlines

lör 8/24:29 pmFSD - TYS

1 stop5h 06mAmerican Airlines

Deal found 7/27

$339

tors 7/315:46 pmTYS - FSD

1 stop5h 14mUnited Airlines

lör 8/28:00 amFSD - TYS

1 stop13h 35mUnited Airlines

Deal found 7/27

$594

tors 7/319:45 amTYS - FSD

3 stops34h 31mMultiple Airlines

lör 8/26:55 pmFSD - TYS

1 stop15h 26mMultiple Airlines

Deal found 7/27

$794

ons 8/136:14 pmTYS - FSD

1 stop5h 52mDelta

sön 8/175:27 amFSD - TYS

1 stop4h 36mDelta

Deal found 7/29

$259

One-way flights from Knoxville to Sioux Falls
Search for one-way flight options from Knoxville to Sioux Falls. Find affordable one-way fares based on user searches. Data last updated juli 29, 2025.

tors 8/283:24 pmTYS - FSD

2 stops18h 14mMultiple Airlines

Deal found 7/29

$160

ons 8/66:15 pmTYS - FSD

1 stop6h 29mDelta

Deal found 7/29

$166

fre 8/1512:03 pmTYS - FSD

2 stops10h 00mAmerican Airlines

Deal found 7/29

$327

ons 8/277:00 amTYS - FSD

3 stops17h 40mUnited Airlines

Deal found 7/29

$507

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Sioux Falls that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

tors 9/11

8:40 pm-2:09 pm

1 stop18h 29m

Sioux Falls Joe Foss Field

sön 9/14

2:54 pm-7:45 pm

1 stop27h 51m

$225

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

tors 9/11

6:00 pm-10:44 pm

1 stop5h 44m

Sioux Falls Joe Foss Field

sön 9/14

5:00 am-1:07 pm

2 stops7h 07m

$254

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

mån 10/6

6:00 am-12:47 pm

1 stop7h 47m

Sioux Falls Joe Foss Field

sön 10/12

5:07 pm-11:51 pm

1 stop5h 44m

$366

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

tors 8/28

3:24 pm-8:38 am

2 stops18h 14m

$160

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

ons 8/6

6:15 pm-11:44 pm

1 stop6h 29m

$166

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

fre 8/15

12:03 pm-9:03 pm

2 stops10h 00m

$327

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

ons 8/27

7:00 am-11:40 pm

3 stops17h 40m

$507

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Best time to book a flight from Knoxville to Sioux Falls

Have a flexible travel schedule? Discover the best time to fly to Sioux Falls from Knoxville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Sioux Falls

What is the cheapest month to book a flight from Knoxville to Sioux Falls?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Sioux Falls (average of $334). Flying from Knoxville to Sioux Falls in December is currently the most expensive (average of $446). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to FSD?

One of the essential ways to save on airfare from Knoxville to Sioux Falls is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the morning could potentially save you up to 24% on airfare.

How much does it cost to fly round-trip from Knoxville to Sioux Falls?

Reviews of airlines servicing Sioux Falls

Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Knoxville to Sioux Falls by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,977 reviews

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,899 reviews

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Frontier

5.9

Fair

3,238 reviews

Delta

8.0

Very good

7,977 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from Knoxville to Sioux Falls round-trip?
Flying on Frontier is currently your cheapest option to Sioux Falls, with prices starting at $225. Additional round-trip tickets that might be worth considering are offered by Delta and American Airlines, with the lowest prices starting at $254 and $366, respectively. Users have found that Frontier is 48% cheaper than the other options available to this destination.
What are the cheapest airlines to fly from Knoxville to Sioux Falls one-way?
The cheapest airlines for a one-way flight from Knoxville to Sioux Falls are Delta ($166), American Airlines ($327), and United Airlines ($507).
Can I find deals for flights from Knoxville to Sioux Falls that include hotel bookings?
Yes. In addition to deals on Knoxville to Sioux Falls flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Knoxville to Sioux Falls?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Sioux Falls.
Can I find deals for business class flights from Knoxville to Sioux Falls?
Yes. Cheapflights offers flight deals from Knoxville to Sioux Falls by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Knoxville to Sioux Falls?
Currently, September is the cheapest month in which you can book a flight from Knoxville to Sioux Falls (average of $334). Flying from Knoxville to Sioux Falls in December is currently the most expensive (average of $446). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Knoxville to Sioux Falls

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$248	Average$494	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$357	Average$636	FlexibilityNo cancel fee	On-time69%

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$160+ Cheap flights from Knoxville to Sioux Falls (TYS - FSD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/28. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Knoxville to Sioux Falls with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Knoxville to Sioux Falls

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Knoxville to Sioux Falls

Cheapest flights from Knoxville to Sioux FallsExplore the most affordable flight options available from Knoxville to Sioux Falls. Find the lowest fares from popular airlines and budget airlines, with prices last updated on juli 29, 2025.

Explore the most affordable flight options available from Knoxville to Sioux Falls. Find the lowest fares from popular airlines and budget airlines, with prices last updated on juli 29, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Sioux Falls that are best for you.

Best time to book a flight from Knoxville to Sioux Falls

Have a flexible travel schedule? Discover the best time to fly to Sioux Falls from Knoxville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Sioux Falls

What is the cheapest month to book a flight from Knoxville to Sioux Falls?

What is the cheapest time of day to fly from TYS to FSD?

Find hourly flight availability from Knoxville to Sioux Falls. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated juli 29, 2025.

How much does it cost to fly round-trip from Knoxville to Sioux Falls?

Reviews of airlines servicing Sioux Falls

Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Knoxville to Sioux Falls by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Sioux Falls. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Knoxville to Sioux Falls round-trip?

What are the cheapest airlines to fly from Knoxville to Sioux Falls one-way?

Can I find deals for flights from Knoxville to Sioux Falls that include hotel bookings?

How can I find direct flights from Knoxville to Sioux Falls?

Can I find deals for business class flights from Knoxville to Sioux Falls?

What is the cheapest month to book a flight from Knoxville to Sioux Falls?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Sioux Falls

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Knoxville to Sioux Falls

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Book with Flexibility

Travel Smart

Cheapest flights from Knoxville to Sioux Falls
Explore the most affordable flight options available from Knoxville to Sioux Falls. Find the lowest fares from popular airlines and budget airlines, with prices last updated on juli 29, 2025.