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Sao Paulo

$647+ Cheap flights from Knoxville (TYS) to Sao Paulo, Brazil (SAO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/2. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAO
Mar 22 — Mar 291
Sun 3/22
Sun 3/29
1 adult, Economy
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Cheap flight deals from Knoxville to Sao Paulo

Cheapest flights from Knoxville to Sao Paulo
Explore the most affordable flight options available from Knoxville to Sao Paulo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/98:20 am
TYS
-
GRU
1 stop19h 30m
Multiple Airlines
Wed 5/133:15 am
GRU
-
TYS
2 stops18h 35m
Multiple Airlines
Deal found 2/20$799
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:30 am
TYS
-
GRU
1 stop36h 25m
Multiple Airlines
Mon 3/91:00 am
GRU
-
TYS
2 stops20h 42m
Multiple Airlines
Deal found 2/18$842
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/232:06 pm
TYS
-
GRU
2 stops38h 49m
Multiple Airlines
Fri 3/612:45 pm
GRU
-
TYS
1 stop29h 41m
Multiple Airlines
Deal found 2/19$855
This KAYAK deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:38 pm
TYS
-
GRU
2 stops22h 37m
LATAM Airlines
Sat 5/308:15 am
GRU
-
TYS
2 stops16h 34m
LATAM Airlines
Deal found 2/20$1,135
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/95:48 pm
TYS
-
GRU
1 stop14h 57m
United Airlines
Thu 5/1410:20 pm
GRU
-
TYS
1 stop19h 34m
United Airlines
Deal found 2/20$1,138
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/91:20 pm
TYS
-
GRU
2 stops18h 00m
American Airlines
Thu 5/1411:15 pm
GRU
-
TYS
2 stops17h 23m
American Airlines
Deal found 2/20$1,142
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:49 am
TYS
-
GRU
1 stop21h 41m
United Airlines
Sat 5/3010:20 pm
GRU
-
TYS
1 stop19h 41m
United Airlines
Deal found 2/19$1,143
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1312:00 pm
TYS
-
GRU
1 stop17h 30m
United Airlines
Mon 8/179:50 pm
GRU
-
TYS
1 stop16h 30m
United Airlines
Deal found 2/17$1,163
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/11:20 pm
TYS
-
GRU
1 stop18h 40m
American Airlines
Sat 5/3010:00 pm
GRU
-
TYS
1 stop16h 03m
American Airlines
Deal found 2/20$1,198

Find flight deals from Knoxville to Sao Paulo

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Sao Paulo (SAO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$799
(Kiwi.com)

One-way from

$647
(Booking.com)
Provider with most accurate pricing for Knoxville McGhee Tyson-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Sao Paulo (SAO) flights.
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From Knoxville McGhee Tyson to Sao Paulo (SAO)
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One-way flight from Knoxville McGhee Tyson to Sao Paulo (SAO)
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Sao Paulo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2026.
Use the filters below to find and compare flights from Knoxville to Sao Paulo that are best for you.

Fly from

Knoxville

Fly to

Sao Paulo

Route

Depart

Return

Price

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Thu 3/5

6:30 am-8:55 pm

1 stop36h 25m

Sao Paulo Guarulhos Intl

Mon 3/9

1:00 am-8:42 pm

2 stops20h 42m

$842

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Mon 2/23

2:06 pm-6:55 am

2 stops38h 49m

Sao Paulo Guarulhos Intl

Fri 3/6

12:45 pm-4:26 pm

1 stop29h 41m

$855

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Fri 5/1

7:00 pm-4:40 pm

2 stops20h 40m

Sao Paulo Guarulhos Intl

Sat 5/30

8:15 am-11:49 pm

2 stops16h 34m

$1,135

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Thu 4/9

5:48 pm-9:45 am

1 stop14h 57m

Sao Paulo Guarulhos Intl

Thu 5/14

10:20 pm-4:54 pm

1 stop19h 34m

$1,138

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Fri 5/1

10:49 am-9:30 am

1 stop21h 41m

Sao Paulo Guarulhos Intl

Sat 5/30

10:20 pm-5:01 pm

1 stop19h 41m

$1,143

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Thu 3/5

6:41 pm-9:35 am

1 stop12h 54m

Sao Paulo Guarulhos Intl

Sat 3/14

11:10 am-8:08 am

2 stops45h 58m

$1,384

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sat 2/28

7:25 pm-1:35 am

2 stops52h 10m

Sao Paulo Guarulhos Intl

Sat 3/21

7:30 am-11:57 pm

2 stops17h 27m

$1,433

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sun 3/1

5:27 pm-7:15 am

1 stop35h 48m

Sao Paulo Guarulhos Intl

Wed 4/1

10:20 pm-5:01 pm

1 stop19h 41m

$1,466

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sat 5/2

7:18 pm-1:10 am

2 stops28h 52m

$647

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Thu 4/23

4:38 pm-7:15 pm

2 stops25h 37m

$663

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/17

Showing 1-10 of 12 results
1
2
  • Most accurate provider: When it comes to deals on Knoxville-Sao Paulo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Sao Paulo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Sao Paulo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Sao Paulo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Sao Paulo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Sao Paulo

Have a flexible travel schedule? Discover the best time to fly to Sao Paulo from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Sao Paulo
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Sao Paulo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Sao Paulo?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Sao Paulo. You should not have trouble finding flights to Sao Paulo from McGhee Tyson; the airport handles an average of 0 outbound flights to Sao Paulo per day. You should also have plenty of airline options to choose from since 0 airlines have flights from the Knoxville airport to Sao Paulo. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Sao Paulo?

    For as low as $1,138, LATAM Airlines can have you in Sao Paulo from Knoxville in 14h 57m. There are 4768 mi between Knoxville and Sao Paulo. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Knoxville to Sao Paulo that include hotel bookings?

    Yes. In addition to deals on Knoxville to Sao Paulo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Sao Paulo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Sao Paulo.

  • Can I find deals for business class flights from Knoxville to Sao Paulo?

    Yes. Cheapflights offers flight deals from Knoxville to Sao Paulo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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