HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Sao Paulo

$591+ Cheap flights from Knoxville (TYS) to Sao Paulo, Brazil (SAO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/27. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAO
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Sao Paulo with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Knoxville to Sao Paulo

Cheapest flights from Knoxville to Sao Paulo
Explore the most affordable flight options available from Knoxville to Sao Paulo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This FlightHub deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:39 pmTYS - GRU
2 stops20h 46mLATAM Airlines
Fri 1/210:20 amGRU - TYS
2 stops33h 54mLATAM Airlines
Deal found 11/4$1,620
This Ovago deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1011:25 amTYS - GRU
2 stops15h 55mLATAM Airlines
Thu 11/2010:50 pmGRU - TYS
2 stops20h 01mLATAM Airlines
Deal found 11/5$1,668
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1010:50 amTYS - GRU
1 stop18h 25mUnited Airlines
Thu 11/2010:25 pmGRU - TYS
1 stop14h 23mUnited Airlines
Deal found 11/5$1,675
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:03 pmTYS - GRU
1 stop13h 02mAmerican Airlines
Thu 1/112:15 amGRU - TYS
1 stop26h 23mAmerican Airlines
Deal found 11/4$1,989

Cheap flight deals from Knoxville to Sao Paulo

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Sao Paulo (SAO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$1,029
(KAYAK)

One-way from

$591
(United Airlines)
Provider with most accurate pricing for Knoxville McGhee Tyson-Sao Paulo (SAO) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Sao Paulo (SAO) flights.
Search Deals
From Knoxville McGhee Tyson to Sao Paulo (SAO)
Search Deals
One-way flight from Knoxville McGhee Tyson to Sao Paulo (SAO)
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Sao Paulo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Knoxville to Sao Paulo that are best for you.

Fly from

Knoxville

Fly to

Sao Paulo

Route

Depart

Return

Price

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sun 3/1

6:41 pm-8:00 pm

2 stops23h 19m

Sao Paulo Guarulhos Intl

Wed 4/1

10:50 pm-11:07 am

1 stop13h 17m

$1,029

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sun 3/1

5:27 pm-7:15 am

1 stop35h 48m

Sao Paulo Guarulhos Intl

Wed 4/1

10:20 pm-4:49 pm

1 stop19h 29m

$1,048

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sun 1/4

7:23 pm-10:20 am

1 stop12h 57m

Sao Paulo Guarulhos Intl

Sun 1/18

9:45 pm-9:02 pm

1 stop25h 17m

$1,129

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Sun 3/22

7:20 pm-5:40 am

1 stop33h 20m

Sao Paulo Guarulhos Intl

Wed 3/25

11:45 pm-6:14 pm

1 stop19h 29m

$1,147

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Fri 3/27

9:40 am-7:15 am

2 stops20h 35m

$591

KnoxvilleSao Paulo

TYS - GRU

TYSGRU

Knoxville McGhee Tyson

Fri 3/27

4:00 pm-12:40 am

3 stops31h 40m

$595

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Compare providers for flights from Knoxville to Sao Paulo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Sao Paulo in November.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Sao Paulo flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Sao Paulo flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Sao Paulo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Sao Paulo flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Sao Paulo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Sao Paulo

Have a flexible travel schedule? Discover the best time to fly to Sao Paulo from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Sao Paulo

What is the cheapest time of day to fly from TYS to SAO?

Find hourly flight availability from Knoxville to Sao Paulo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

When flying from Knoxville to Sao Paulo, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 56% versus a flight in the morning.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Sao Paulo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Sao Paulo?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Sao Paulo. You should not have trouble finding flights to Sao Paulo from McGhee Tyson; the airport handles an average of 0 outbound flights to Sao Paulo per day. You should also have plenty of airline options to choose from since 0 airlines have flights from the Knoxville airport to Sao Paulo. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Sao Paulo?

    For as low as $1,029, LATAM Airlines can have you in Sao Paulo from Knoxville in 23h 19m. There are 4768 mi between Knoxville and Sao Paulo. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Knoxville to Sao Paulo that include hotel bookings?

    Yes. In addition to deals on Knoxville to Sao Paulo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Sao Paulo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Sao Paulo.

  • Can I find deals for business class flights from Knoxville to Sao Paulo?

    Yes. Cheapflights offers flight deals from Knoxville to Sao Paulo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Sao Paulo

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Guarulhos Intl flights
Nashville to Viracopos flights
Memphis to Guarulhos Intl flights
Knoxville to Guarulhos Intl flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.