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Santo Domingo

$287+ Cheap flights from Greenville (GSP) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/27. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SDQ
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Cheap flight deals from Greenville to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$445
(Kiwi.com)

One-way from

$233
(Kiwi.com)

Popular in

December

Cheapest in

May

Average price

$563
Provider with most accurate pricing for Greenville-Santo Domingo Las Americas flight deals.
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Provider most trusted by Cheapflights users for Greenville-Santo Domingo Las Americas flights.
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From Greenville to Santo Domingo Las Americas
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One-way flight from Greenville to Santo Domingo Las Americas
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Highest demand for flights based on searches. 6% potential increase in price ($41 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($29 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Greenville to Santo Domingo

Cheapest flights from Greenville to Santo Domingo
Explore the most affordable flight options available from Greenville to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/271:58 pmGSP - SDQ
2 stops10h 38mDelta
Mon 12/18:40 pmSDQ - GSP
1 stop15h 15mDelta
Deal found 11/5$572
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:10 amGSP - SDQ
1 stop11h 13mAmerican Airlines
Sun 12/146:23 pmSDQ - GSP
1 stop16h 33mAmerican Airlines
Deal found 11/5$633
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/265:15 amGSP - SDQ
2 stops9h 30mAmerican Airlines
Mon 12/14:45 pmSDQ - GSP
1 stop8h 14mAmerican Airlines
Deal found 11/5$642
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2111:33 amGSP - SDQ
1 stop22h 47mMultiple Airlines
Sun 12/284:21 pmSDQ - GSP
1 stop27h 14mMultiple Airlines
Deal found 11/5$647
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/285:00 amGSP - SDQ
1 stop11h 08mAmerican Airlines
Mon 12/14:45 pmSDQ - GSP
1 stop8h 14mAmerican Airlines
Deal found 11/5$648
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/263:50 pmGSP - SDQ
2 stops22h 40mMultiple Airlines
Sun 11/304:35 pmSDQ - GSP
1 stop23h 08mMultiple Airlines
Deal found 11/5$700

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Greenville to Santo Domingo that are best for you.

Fly from

Greenville

Fly to

Santo Domingo

Route

Depart

Return

Price

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Mon 1/19

9:48 am-3:35 pm

1 stop28h 47m

Santo Domingo Las Americas

Sun 1/25

4:40 pm-8:58 am

1 stop17h 18m

$454

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Mon 1/19

6:00 am-10:39 pm

2 stops15h 39m

Santo Domingo Las Americas

Sun 1/25

4:47 pm-11:57 pm

1 stop8h 10m

$487

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Thu 1/22

6:55 pm-12:21 pm

1 stop16h 26m

Santo Domingo Las Americas

Mon 1/26

4:47 pm-11:57 pm

1 stop8h 10m

$488

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Tue 3/3

6:49 am-2:15 pm

1 stop6h 26m

Santo Domingo Las Americas

Fri 3/6

7:05 am-9:40 pm

2 stops15h 35m

$522

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Mon 4/13

5:57 am-9:50 pm

1 stop15h 53m

Santo Domingo Las Americas

Sat 4/18

1:28 pm-11:03 pm

1 stop9h 35m

$568

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Thu 11/27

1:58 pm-1:36 am

2 stops10h 38m

Santo Domingo Las Americas

Mon 12/1

8:40 pm-10:55 am

1 stop15h 15m

$572

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Thu 11/27

7:38 am-5:08 pm

2 stops8h 30m

$287

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Fri 11/28

5:00 am-5:08 pm

1 stop11h 08m

$342

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Wed 11/26

5:15 am-3:45 pm

2 stops9h 30m

$342

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Sun 12/21

11:33 am-11:20 am

1 stop22h 47m

$366

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Showing 1-10 of 12 results
1
2

Compare providers for flights from Greenville to Santo Domingo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Santo Domingo in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-Santo Domingo flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Greenville-Santo Domingo flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Greenville-Santo Domingo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-Santo Domingo flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Santo Domingo

What is the cheapest month to book a flight from Greenville to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Greenville to Santo Domingo (average of $226). Flying from Greenville to Santo Domingo in December is currently the most expensive (average of $400). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Greenville to Santo Domingo?

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated November 6, 2025.
Read through reviews of airlines operating flights from Greenville to Santo Domingo, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,001 reviews

Boarding

8.2

Overall

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,001 reviews
Delta
7.9
Good
8,001 reviews

Boarding

8.2

Overall

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,040 reviews
Delta
7.9
Good
8,001 reviews

Boarding

8.2

Overall

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Santo Domingo?

    Airlines like American Airlines fly from Greenville to Santo Domingo in about 15h 39m. The time it takes to get you to your destination can typically vary by up to . There are 1373 mi between Greenville and Santo Domingo.

  • What are the cheapest airlines flying from Greenville to Santo Domingo round-trip?

    Our cheapest airline available from Greenville to Santo Domingo is Delta. Our recent data shows that you can find tickets from as low as $484 on this airline. An additional option worth looking into is American Airlines, starting at $511. Delta is priced at 24% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Greenville to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Greenville to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Santo Domingo.

  • Can I find deals for business class flights from Greenville to Santo Domingo?

    Yes. Cheapflights offers flight deals from Greenville to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Greenville to Santo Domingo (average of $226). Flying from Greenville to Santo Domingo in December is currently the most expensive (average of $400). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Top 2 airlines flying from Greenville to Santo Domingo

Discover the top 2 airlines that operate flights from Greenville to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$484Average$484FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$511Average$604FlexibilityNo cancel feeOn-time71%

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