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Santo Domingo

$200+ Cheap flights from Greenville (GSP) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/18. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SDQ
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Greenville to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$420
(Kiwi.com)

One-way from

$200
(Kiwi.com)

Popular in

December

Cheapest in

May

Average price

$527
From Greenville to Santo Domingo Las Americas
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One-way flight from Greenville to Santo Domingo Las Americas
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Highest demand for flights based on searches. 1% potential increase in price ($7 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($18 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Greenville to Santo Domingo

Cheapest flights from Greenville to Santo Domingo
Explore the most affordable flight options available from Greenville to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/16:24 pmGSP - SDQ
2 stops17h 55mAmerican Airlines
Sat 11/86:14 pmSDQ - GSP
1 stop6h 45mAmerican Airlines
Deal found 9/17$482
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/66:23 pmGSP - SDQ
1 stop17h 05mAmerican Airlines
Mon 12/83:06 pmSDQ - GSP
2 stops9h 02mAmerican Airlines
Deal found 9/16$491
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/116:00 amGSP - SDQ
1 stop8h 06mUnited Airlines
Mon 11/174:18 pmSDQ - GSP
1 stop8h 38mUnited Airlines
Deal found 9/15$577
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/186:35 amGSP - SDQ
2 stops13h 55mAmerican Airlines
Sun 9/217:00 amSDQ - GSP
2 stops12h 14mAmerican Airlines
Deal found 9/16$742
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/182:33 pmGSP - SDQ
2 stops10h 03mDelta
Sun 9/212:50 pmSDQ - GSP
1 stop9h 02mDelta
Deal found 9/17$802
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/198:08 pmGSP - SDQ
1 stop18h 41mAmerican Airlines
Sun 1/117:05 amSDQ - GSP
1 stop14h 30mAmerican Airlines
Deal found 9/17$818
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/198:03 pmGSP - SDQ
1 stop13h 08mMultiple Airlines
Sun 1/113:30 pmSDQ - GSP
2 stops29h 37mMultiple Airlines
Deal found 9/17$866

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Greenville to Santo Domingo that are best for you.

Fly from

Greenville

Fly to

Santo Domingo

Route

Depart

Return

Price

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Sat 11/1

6:24 pm-2:05 pm

2 stops19h 41m

Santo Domingo Las Americas

Sat 11/8

1:19 pm-11:58 pm

2 stops11h 39m

$482

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Sat 12/6

5:15 am-12:28 pm

1 stop6h 13m

Santo Domingo Las Americas

Mon 12/8

1:28 pm-11:59 pm

1 stop11h 31m

$487

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Tue 11/11

6:00 am-3:06 pm

1 stop8h 06m

Santo Domingo Las Americas

Mon 11/17

4:18 pm-11:56 pm

1 stop8h 38m

$577

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Sun 10/19

3:42 pm-4:07 pm

2 stops24h 25m

$228

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Mon 10/20

8:51 pm-9:45 pm

3 stops24h 54m

$241

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Thu 10/16

4:47 pm-4:07 pm

2 stops23h 20m

$247

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Tue 10/21

4:18 pm-2:48 pm

3 stops46h 30m

$257

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Sun 10/19

6:05 am-2:10 pm

1 stop8h 05m

$281

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Wed 10/22

7:52 am-1:41 pm

1 stop5h 49m

$281

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Tue 10/21

5:30 am-1:41 pm

1 stop8h 11m

$281

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 11 results
1
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Best time to book a flight from Greenville to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Santo Domingo

What is the cheapest month to book a flight from Greenville to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Greenville to Santo Domingo (average of $362). Flying from Greenville to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated September 17, 2025.
Read through reviews of airlines operating flights from Greenville to Santo Domingo, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Greenville to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Santo Domingo?

    Airlines like American Airlines fly from Greenville to Santo Domingo in about 19h 41m. The time it takes to get you to your destination can typically vary by up to . There are 1373 mi between Greenville and Santo Domingo.

  • What are the cheapest airlines flying from Greenville to Santo Domingo round-trip?

    Our cheapest airline available from Greenville to Santo Domingo is Delta. Our recent data shows that you can find tickets from as low as $484 on this airline. An additional option worth looking into is American Airlines, starting at $511. Delta is priced at 22% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Greenville to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Greenville to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Santo Domingo.

  • Can I find deals for business class flights from Greenville to Santo Domingo?

    Yes. Cheapflights offers flight deals from Greenville to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Greenville to Santo Domingo (average of $362). Flying from Greenville to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Top 2 airlines flying from Greenville to Santo Domingo

Discover the top 2 airlines that operate flights from Greenville to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$484Average$484FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$511Average$608FlexibilityNo cancel feeOn-time71%

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