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Santo Domingo

$298+ Cheap flights from Greenville (GSP) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/18. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SDQ
Mar 20 — Mar 271
Fri 3/20
Fri 3/27
1 adult, Economy
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Cheap flight deals from Greenville to Santo Domingo

Cheapest flights from Greenville to Santo Domingo
Explore the most affordable flight options available from Greenville to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 18, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/166:05 pm
GSP
-
SDQ
1 stop7h 33m
Multiple Airlines
Sun 3/222:52 am
SDQ
-
GSP
1 stop12h 46m
Multiple Airlines
Deal found 2/17$424
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:33 pm
GSP
-
SDQ
1 stop7h 05m
Multiple Airlines
Sat 4/116:57 pm
SDQ
-
GSP
1 stop18h 56m
Multiple Airlines
Deal found 2/16$489
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/208:35 pm
GSP
-
SDQ
1 stop12h 49m
American Airlines
Fri 6/267:40 pm
SDQ
-
GSP
1 stop15h 52m
American Airlines
Deal found 2/17$499
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/176:00 am
GSP
-
SDQ
2 stops10h 50m
American Airlines
Tue 3/246:00 am
SDQ
-
GSP
2 stops13h 07m
American Airlines
Deal found 2/17$503
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/92:12 pm
GSP
-
SDQ
2 stops22h 09m
Multiple Airlines
Sun 4/193:44 pm
SDQ
-
GSP
1 stop25h 09m
Multiple Airlines
Deal found 2/16$506
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:00 am
GSP
-
SDQ
1 stop16h 55m
American Airlines
Fri 6/197:40 pm
SDQ
-
GSP
1 stop15h 52m
American Airlines
Deal found 2/18$509
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/187:26 pm
GSP
-
SDQ
1 stop13h 34m
American Airlines
Wed 3/256:00 am
SDQ
-
GSP
2 stops12h 13m
American Airlines
Deal found 2/17$513
This American Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:00 am
GSP
-
SDQ
1 stop10h 55m
American Airlines
Sun 5/247:00 am
SDQ
-
GSP
1 stop12h 37m
American Airlines
Deal found 2/15$514
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/296:05 am
GSP
-
SDQ
1 stop12h 47m
Delta
Tue 4/76:35 am
SDQ
-
GSP
2 stops17h 19m
Delta
Deal found 2/16$521

Find flight deals from Greenville to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 18, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$424
(Kiwi.com)

Popular in

December

Cheapest in

May

Average price

$562
Provider with most accurate pricing for Greenville-Santo Domingo Las Americas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Santo Domingo Las Americas flights.
Search Deals
From Greenville to Santo Domingo Las Americas
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($95 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($40 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 18, 2026.
Use the filters below to find and compare flights from Greenville to Santo Domingo that are best for you.

Fly from

Greenville

Fly to

Santo Domingo

Route

Depart

Return

Price

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Mon 3/16

6:05 pm-1:38 am

1 stop7h 33m

Santo Domingo Las Americas

Sun 3/22

2:52 am-3:38 pm

1 stop12h 46m

$424

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Sat 6/20

8:35 pm-9:24 am

1 stop12h 49m

Santo Domingo Las Americas

Fri 6/26

7:40 pm-11:32 am

1 stop15h 52m

$499

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Sun 3/29

6:05 am-6:52 pm

1 stop12h 47m

Santo Domingo Las Americas

Tue 4/7

8:25 pm-10:59 am

1 stop14h 34m

$499

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Tue 3/17

7:26 pm-9:00 am

1 stop13h 34m

Santo Domingo Las Americas

Tue 3/24

2:16 pm-12:21 am

1 stop10h 05m

$499

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Wed 4/1

6:05 am-6:52 pm

1 stop12h 47m

Santo Domingo Las Americas

Tue 4/7

8:25 pm-10:59 am

1 stop14h 34m

$499

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Tue 3/31

6:05 am-6:52 pm

1 stop12h 47m

Santo Domingo Las Americas

Tue 4/7

8:25 pm-10:59 am

1 stop14h 34m

$499

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Wed 3/18

5:40 am-1:10 pm

1 stop7h 30m

Santo Domingo Las Americas

Wed 3/25

6:57 am-5:29 pm

2 stops10h 32m

$503

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Wed 3/18

6:00 am-4:50 pm

2 stops10h 50m

$298

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Tue 3/17

8:46 am-10:53 pm

2 stops14h 07m

$303

GreenvilleSanto Domingo

GSP - SDQ

GSPSDQ

Greenville

Wed 3/18

5:40 am-3:30 am

3 stops21h 50m

$478

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/18

Showing 1-10 of 11 results
1
2

Compare providers for flights from Greenville to Santo Domingo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Santo Domingo in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
OvagoPrice Accuracy2 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*2 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Santo Domingo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Santo Domingo

What is the cheapest month to book a flight from Greenville to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Greenville to Santo Domingo (average of $261). Flying from Greenville to Santo Domingo in December is currently the most expensive (average of $365). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated February 18, 2026.
Read through reviews of airlines operating flights from Greenville to Santo Domingo, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,208 reviews

Crew

8.5

Overall

7.9

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,208 reviews
Delta
7.9
Good
8,208 reviews

Crew

8.5

Overall

7.9

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,307 reviews
Delta
7.9
Good
8,208 reviews

Crew

8.5

Overall

7.9

Entertainment

7.8

Boarding

8.1

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Santo Domingo?

    Airlines like American Airlines and Delta fly from Greenville to Santo Domingo in about 12h 47m. The time it takes to get you to your destination can typically vary by up to 02m. There are 1373 mi between Greenville and Santo Domingo. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Greenville to Santo Domingo round-trip?

    Our cheapest airline available from Greenville to Santo Domingo is Delta. Our recent data shows that you can find tickets from as low as $484 on this airline. An additional option worth looking into is American Airlines, starting at $488. Delta is priced at 17% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Greenville to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Greenville to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Santo Domingo.

  • Can I find deals for business class flights from Greenville to Santo Domingo?

    Yes. Cheapflights offers flight deals from Greenville to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Greenville to Santo Domingo (average of $261). Flying from Greenville to Santo Domingo in December is currently the most expensive (average of $365). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Greenville to Santo Domingo

Discover the top 2 airlines that operate flights from Greenville to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 18, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$484Average$517FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$488Average$558FlexibilityNo cancel feeOn-time71%

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