$195+ Cheap flights from St. Louis (STL) to Santiago de los Caballeros (STI)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/29. Fares are subject to change and may not be available on all flights or dates of travel.
STL — STI
Apr 29 — May 61
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Santiago de los Caballeros with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Santiago de los Caballeros
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to Santiago de los CaballerosExplore the most affordable flight options available from St. Louis to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 30, 2026.
Explore the most affordable flight options available from St. Louis to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 30, 2026.
This Trip.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:55 pm
STL
- STI
2 stops19h 25m
Multiple Airlines
Sun 5/173:07 pm
STI
- STL
2 stops18h 48m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$472
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/411:15 am
STL
- STI
1 stop8h 58m
American Airlines
Tue 6/99:06 am
STI
- STL
1 stop14h 52m
American Airlines
Deal found 3/29![American Airlines logo]()
$589
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:15 am
STL
- STI
2 stops13h 58m
American Airlines
Tue 6/29:06 am
STI
- STL
2 stops15h 38m
American Airlines
Deal found 3/27![American Airlines logo]()
$593
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:24 am
STL
- STI
1 stop5h 59m
American Airlines
Mon 5/181:32 pm
STI
- STL
1 stop9h 52m
American Airlines
Deal found 3/25![American Airlines logo]()
$619
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:24 am
STL
- STI
1 stop5h 59m
American Airlines
Sun 5/171:32 pm
STI
- STL
1 stop9h 52m
American Airlines
Deal found 3/25![American Airlines logo]()
$624
Best flights from St. Louis to Santiago de los CaballerosDiscover carefully curated flight deals from St. Louis to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 30, 2026.
Discover carefully curated flight deals from St. Louis to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 30, 2026.
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:15 am
STL
- STI
1 stop14h 58m
American Airlines
Tue 6/29:06 am
STI
- STL
1 stop14h 52m
American Airlines
Deal found 3/25![American Airlines logo]()
$609
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:00 am
STL
- STI
1 stop8h 12m
United Airlines
Mon 6/82:07 pm
STI
- STL
1 stop10h 28m
United Airlines
Deal found 3/25![United Airlines logo]()
$609
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/149:15 am
STL
- STI
2 stops14h 44m
Delta
Mon 5/188:59 pm
STI
- STL
2 stops16h 23m
Delta
Deal found 3/25![Delta logo]()
$633
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:24 am
STL
- STI
1 stop5h 59m
American Airlines
Mon 5/181:32 pm
STI
- STL
1 stop9h 52m
American Airlines
Deal found 3/25![American Airlines logo]()
$619
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:45 am
STL
- STI
2 stops11h 43m
Delta
Sun 5/178:59 pm
STI
- STL
2 stops16h 21m
Delta
Deal found 3/26![Delta logo]()
$643
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/217:30 am
STL
- STI
2 stops12h 43m
American Airlines
Thu 5/287:03 am
STI
- STL
2 stops10h 30m
American Airlines
Deal found 3/29![American Airlines logo]()
$643
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/209:10 am
STL
- STI
2 stops12h 42m
United Airlines
Fri 4/244:23 pm
STI
- STL
2 stops20h 59m
United Airlines
Deal found 3/25![United Airlines logo]()
$808
Last-minute flights from St. Louis to Santiago de los CaballerosDiscover last-minute flight deals from St. Louis to Santiago de los Caballeros. Data last updated March 30, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Santiago de los Caballeros. Data last updated March 30, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/56:15 am
STL
- STI
1 stop7h 57m
United Airlines
Sat 4/114:23 pm
STI
- STL
1 stop8h 34m
United Airlines
Deal found 3/26![United Airlines logo]()
$872
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/56:13 am
STL
- STI
2 stops13h 16m
American Airlines
Sat 4/111:32 pm
STI
- STL
2 stops20h 22m
American Airlines
Deal found 3/26![American Airlines logo]()
$991
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:15 am
STL
- STI
1 stop7h 57m
United Airlines
Fri 4/242:07 pm
STI
- STL
2 stops21h 38m
United Airlines
Deal found 3/25![United Airlines logo]()
$808
One-way flights from St. Louis to Santiago de los CaballerosSearch for one-way flight options from St. Louis to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated March 30, 2026.
Search for one-way flight options from St. Louis to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated March 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/298:23 pm
STL
- STI
2 stops16h 39m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/28:23 pm
STL
- STI
2 stops16h 39m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:23 pm
STL
- STI
2 stops16h 39m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:55 pm
STL
- STI
2 stops19h 25m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3011:21 am
STL
- STI
2 stops25h 41m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$223
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:23 pm
STL
- STI
2 stops16h 39m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/34:59 pm
STL
- STI
3 stops21h 21m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/169:18 pm
STL
- STI
3 stops41h 02m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:55 pm
STL
- STI
2 stops19h 25m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$290
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/114:25 pm
STL
- STI
1 stop7h 34m
Delta
Deal found 3/29![Delta logo]()
$333
Find flight deals from St. Louis to Santiago de los Caballeros
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago de los Caballeros (STI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $472 (Trip.com) |
One-way from | $195 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 30, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago de los Caballeros that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Thu 5/28
5:15 am-9:13 pm
1 stop14h 58m
Santiago de los Caballeros
Tue 6/2
9:06 am-10:58 pm
1 stop14h 52m
$609
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Thu 6/4
6:00 am-3:12 pm
1 stop8h 12m
Santiago de los Caballeros
Mon 6/8
2:07 pm-11:35 pm
1 stop10h 28m
$609
Quickest round-trip
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Thu 5/14
5:24 am-12:23 pm
1 stop5h 59m
Santiago de los Caballeros
Mon 5/18
1:32 pm-10:24 pm
1 stop9h 52m
$619
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Thu 5/14
9:15 am-12:59 am
2 stops14h 44m
Santiago de los Caballeros
Mon 5/18
8:59 pm-12:22 pm
2 stops16h 23m
$633
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Sun 5/10
6:45 am-7:28 pm
2 stops11h 43m
Santiago de los Caballeros
Sun 5/17
8:59 pm-12:20 pm
2 stops16h 21m
$643
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Thu 5/21
7:30 am-9:13 pm
2 stops12h 43m
Santiago de los Caballeros
Thu 5/28
7:03 am-4:33 pm
2 stops10h 30m
$643
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Mon 4/20
9:10 am-10:52 pm
2 stops12h 42m
Santiago de los Caballeros
Fri 4/24
4:23 pm-12:22 pm
2 stops20h 59m
$808
Cheapest one-way
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Wed 4/29
8:23 pm-2:02 pm
2 stops16h 39m
$195
Quickest one-way
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Mon 5/11
4:25 pm-12:59 am
1 stop7h 34m
$333
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Mon 4/20
6:15 am-3:12 pm
1 stop7h 57m
$363
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Santiago de los Caballeros
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago de los Caballeros in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*2 stars |
- Most accurate provider: When it comes to deals on St. Louis-Santiago de los Caballeros flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Santiago de los Caballeros flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago de los Caballeros flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Santiago de los Caballeros flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago de los Caballeros flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Santiago de los Caballeros
Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from St. Louis with our price prediction graph.
STL-STI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Santiago de los Caballeros
Reviews of airlines servicing Santiago de los Caballeros
Get insights into the airlines that provide service to Santiago de los Caballeros. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago de los Caballeros. Reviews last updated March 30, 2026.
Get a feel of what it's like to fly with United Airlines from St. Louis to Santiago de los Caballeros by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Entertainment
7.1
Overall
7.4
Boarding
7.7
Food
6.6
Comfort
7.3
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Crew
8.1
Entertainment
7.1
Overall
7.4
Boarding
7.7
Food
6.6
Comfort
7.3
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Santiago de los Caballeros flight routes
Alternative routes for St. Louis to Santiago de los Caballeros
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Complete your trip
Complete your trip to Santiago de los Caballeros by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Santiago de los Caballeros by cabin class
Find flights from St. Louis to Santiago de los Caballeros, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Santiago de los Caballeros flights
Browse other St. Louis and Santiago de los Caballeros flight options. Last updated on March 30, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on March 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago de los Caballeros
Explore flights to Santiago de los Caballeros departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 30, 2026.
Top airline flying from St. Louis to Santiago de los Caballeros
Discover the top airline that operate flights from St. Louis to Santiago de los Caballeros. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$538 | Average$609 | FlexibilityNo cancel fee | On-time69% |