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Santo Domingo

$157+ Cheap flights from St. Louis (STL) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/5. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SDQ
Jul 21 — Jul 281
Mon 7/21
Mon 7/28
1 adult, Economy
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Cheap flight deals from St. Louis to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 16, 2025.

Round-trip from

$327
(Kiwi.com)

One-way from

$157
(Kiwi.com)

Popular in

September

Cheapest in

March

Average price

$793
From Lambert-St Louis to Santo Domingo Las Americas
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One-way flight from Lambert-St Louis to Santo Domingo Las Americas
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Highest demand for flights based on searches. 13% potential increase in price ($106 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($50 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from St. Louis to Santo Domingo

Cheapest flights from St. Louis to Santo Domingo
Explore the most affordable flight options available from St. Louis to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/55:26 pmSTL - SDQ
1 stop21h 21mSpirit Airlines
Fri 8/84:52 pmSDQ - STL
1 stop22h 47mSpirit Airlines
Deal found 7/14$327
This Frontier deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/32:36 pmSTL - SDQ
1 stop8h 52mFrontier
Sun 8/1011:50 amSDQ - STL
1 stop12h 57mFrontier
Deal found 7/14$433
This Mytrip deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/125:26 pmSTL - SDQ
2 stops17h 30mMultiple Airlines
Tue 8/195:05 pmSDQ - STL
3 stops20h 05mMultiple Airlines
Deal found 7/15$457
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/105:27 amSTL - SDQ
1 stop6h 18mAmerican Airlines
Fri 11/212:25 pmSDQ - STL
1 stop10h 36mAmerican Airlines
Deal found 7/15$515
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:04 amSTL - SDQ
1 stop6h 20mDelta
Tue 10/77:00 amSDQ - STL
2 stops10h 51mDelta
Deal found 7/15$529

Cheapflights Fare Finder

Customize your flight search to find flights from St. Louis to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 16, 2025.
Use the filters below to find and compare flights from St. Louis to Santo Domingo that are best for you.

Fly from

St. Louis

Fly to

Santo Domingo

Route

Depart

Return

Price

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 8/5

5:26 pm-3:47 pm

1 stop21h 21m

Santo Domingo Las Americas

Fri 8/8

4:52 pm-2:39 pm

1 stop22h 47m

$327

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Sun 8/3

2:36 pm-12:28 am

1 stop8h 52m

Santo Domingo Las Americas

Sun 8/10

11:50 am-11:47 pm

1 stop12h 57m

$433

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 8/12

5:26 pm-11:56 am

2 stops17h 30m

Santo Domingo Las Americas

Tue 8/19

5:05 pm-12:10 pm

3 stops20h 05m

$457

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 11/10

5:27 am-1:45 pm

1 stop6h 18m

Santo Domingo Las Americas

Fri 11/21

2:25 pm-11:01 pm

1 stop10h 36m

$515

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Fri 9/26

6:04 am-1:24 pm

1 stop6h 20m

Santo Domingo Las Americas

Tue 10/7

7:00 am-4:51 pm

2 stops10h 51m

$529

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Thu 8/28

9:17 am-1:50 am

2 stops15h 33m

Santo Domingo Las Americas

Thu 9/4

3:20 pm-3:44 pm

2 stops25h 24m

$898

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 8/5

5:26 pm-3:47 pm

1 stop21h 21m

$157

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Tue 8/5

5:26 pm-2:43 am

2 stops32h 17m

$227

St. LouisSanto Domingo

STL - SDQ

STLSDQ

Lambert-St Louis

Mon 8/4

5:00 am-6:20 pm

1 stop12h 20m

$316

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/15

Best time to book a flight from St. Louis to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Santo Domingo

What is the cheapest month to book a flight from St. Louis to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from St. Louis to Santo Domingo (average of $362). Flying from St. Louis to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SDQ?

Find hourly flight availability from St. Louis to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 16, 2025.

It’s typically best to fly out from St. Louis to Santo Domingo at noon. Doing so could potentially save you 28% on the flight price compared to flying in the morning, which is usually more expensive.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated July 16, 2025.
Read through reviews of airlines operating flights from St. Louis to Santo Domingo, such as Delta, American Airlines, and Spirit Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,957 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,957 reviews
Delta
8.0
Very good
7,957 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,957 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Spirit Airlines
6.3
Okay
8,045 reviews
Delta
8.0
Very good
7,957 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Frontier
5.9
Fair
3,256 reviews
Delta
8.0
Very good
7,957 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from St. Louis to Santo Domingo round-trip?

    Flying on Spirit Airlines is currently your cheapest option to Santo Domingo, with prices starting at $327. Additional round-trip tickets that might be worth considering are offered by Frontier and American Airlines, with the lowest prices starting at $433 and $515, respectively. Spirit Airlines is currently priced 52% below the average price you’ll pay for this route.

  • Can I find deals for flights from St. Louis to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on St. Louis to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Santo Domingo.

  • Can I find deals for business class flights from St. Louis to Santo Domingo?

    Yes. Cheapflights offers flight deals from St. Louis to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from St. Louis to Santo Domingo (average of $362). Flying from St. Louis to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Top 3 airlines flying from St. Louis to Santo Domingo

Discover the top 3 airlines that operate flights from St. Louis to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$371Average$384FlexibilityNo cancel feeOn-time62%
DeltaCheapest$423Average$658FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$453Average$640FlexibilityNo cancel feeOn-time71%

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