$253+ Cheap flights from St. Louis (STL) to Santo Domingo (SDQ)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/30. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SDQ
Nov 24 — Dec 11
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Santo Domingo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Santo Domingo
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Cheapest flights from St. Louis to Santo DomingoExplore the most affordable flight options available from St. Louis to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
Explore the most affordable flight options available from St. Louis to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:20 pm -
1 stop16h 50m
Sat 12/123:35 pm -
2 stops45h 42m
Deal found 10/21![Multiple Airlines logo]()
$578
This Mytrip deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/212:05 pm -
3 stops23h 13m
Sat 12/126:10 am -
2 stops20h 02m
Deal found 10/23![Multiple Airlines logo]()
$595
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/84:48 pm -
1 stop17h 07m
Tue 12/157:00 am -
1 stop16h 49m
Deal found 10/24![American Airlines logo]()
$660
This Mytrip deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:20 pm -
2 stops20h 09m
Tue 12/151:27 pm -
3 stops23h 50m
Deal found 10/24![Multiple Airlines logo]()
$663
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:15 pm -
1 stop13h 50m
Mon 12/72:22 pm -
1 stop8h 24m
Deal found 10/21![American Airlines logo]()
$680
Best flights from St. Louis to Santo DomingoDiscover carefully curated flight deals from St. Louis to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
Discover carefully curated flight deals from St. Louis to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:15 pm -
1 stop13h 50m
Mon 12/72:22 pm -
1 stop8h 24m
Deal found 10/24![American Airlines logo]()
$680
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/246:00 am -
1 stop6h 15m
Thu 2/252:35 pm -
2 stops19h 37m
Deal found 10/20![Delta logo]()
$775
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/243:00 pm -
2 stops29h 45m
Thu 12/316:00 am -
2 stops19h 38m
Deal found 10/20![United Airlines logo]()
$871
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/154:25 pm -
2 stops15h 33m
Mon 3/224:06 pm -
1 stop20h 12m
Deal found 10/22![American Airlines logo]()
$700
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/226:00 am -
1 stop6h 15m
Thu 2/252:35 pm -
2 stops19h 37m
Deal found 10/20![Delta logo]()
$775
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/134:25 pm -
2 stops15h 33m
Sat 2/2010:57 am -
2 stops12h 40m
Deal found 10/24![American Airlines logo]()
$765
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/256:06 am -
1 stop15h 40m
Thu 1/282:53 pm -
1 stop8h 56m
Deal found 10/20![United Airlines logo]()
$900
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/296:00 am -
2 stops10h 19m
Sat 12/511:09 am -
2 stops13h 33m
Deal found 10/25![American Airlines logo]()
$825
Last-minute flights from St. Louis to Santo DomingoDiscover last-minute flight deals from St. Louis to Santo Domingo. Data last updated October 25, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Santo Domingo. Data last updated October 25, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am -
1 stop6h 32m
Sat 10/312:57 pm -
1 stop8h 02m
Deal found 10/21![Delta logo]()
$942
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:00 am -
1 stop6h 32m
Sat 10/312:57 pm -
1 stop8h 02m
Deal found 10/21![Delta logo]()
$960
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:00 am -
2 stops11h 06m
Sat 10/317:35 pm -
2 stops17h 16m
Deal found 10/21![Delta logo]()
$965
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:00 am -
1 stop7h 33m
Mon 11/911:19 am -
1 stop8h 06m
Deal found 10/21![American Airlines logo]()
$880
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2910:01 am -
1 stop9h 40m
Sat 12/53:55 pm -
1 stop7h 54m
Deal found 10/25![American Airlines logo]()
$820
One-way flights from St. Louis to Santo DomingoSearch for one-way flight options from St. Louis to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
Search for one-way flight options from St. Louis to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
This Priceline deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/305:58 pm -
1 stop18h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Frontier logo]()
$253
This FlightHub deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/265:59 pm -
1 stop18h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Frontier logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1112:02 pm -
3 stops53h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/24![Multiple Airlines logo]()
$295
This Priceline deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/295:58 pm -
1 stop18h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Frontier logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:59 pm -
2 stops44h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Multiple Airlines logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/315:58 pm -
2 stops45h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Frontier logo]()
$336
Find flight deals from St. Louis to Santo Domingo
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $578 (Kiwi.com) |
One-way from | $253 (Priceline) |
Popular in | December |
Cheapest in | October |
Average price | $600 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
Use the filters below to find and compare flights from St. Louis to Santo Domingo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Wed 12/30
5:58 pm-2:11 pm
1 stop18h 13m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$260
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Fri 12/11
12:02 pm-7:18 pm
3 stops53h 16m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$295
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Sat 10/31
7:59 pm-5:06 pm
2 stops44h 07m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$325
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Thu 12/31
5:58 pm-5:33 pm
2 stops45h 35m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$336
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Wed 2/24
6:59 pm-1:10 pm
2 stops16h 11m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$373
Quickest round-trip
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Tue 2/23
6:00 am-2:15 pm
1 stop6h 15m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$373
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Mon 12/28
7:15 pm-12:36 pm
1 stop15h 21m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$373
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Thu 12/3
6:15 pm-10:05 am
1 stop13h 50m
Santo Domingo Las Americas
Mon 12/7
2:22 pm-8:46 pm
1 stop8h 24m
$680
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Mon 3/15
4:25 pm-8:58 am
2 stops15h 33m
Santo Domingo Las Americas
Mon 3/22
4:06 pm-11:18 am
1 stop20h 12m
$700
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Sat 2/13
4:25 pm-9:58 am
2 stops15h 33m
Santo Domingo Las Americas
Sat 2/20
10:57 am-9:37 pm
2 stops12h 40m
$765
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Santo Domingo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santo Domingo in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on St. Louis-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Santo Domingo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Santo Domingo
Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from St. Louis with our price prediction graph.
STL-SDQ
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Santo Domingo
Reviews of airlines servicing Santo Domingo
Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated October 25, 2026.
Read through reviews of airlines operating flights from St. Louis to Santo Domingo, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
6.4
Comfort
7.1
Boarding
7.4
Entertainment
6.8
Overall
7.0
Crew
7.9
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Food
6.4
Comfort
7.1
Boarding
7.4
Entertainment
6.8
Overall
7.0
Crew
7.9
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santo Domingo?
Book flights to Santo Domingo if you plan to visit one of these locationsJuan Dolio
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Complete your trip
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St. Louis and Santo Domingo flights
Browse other St. Louis and Santo Domingo flight options. Last updated on October 25, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Popular flight searches
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Other flights to Santo Domingo
Explore flights to Santo Domingo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Top airline flying from St. Louis to Santo Domingo
Discover the top airline that operate flights from St. Louis to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$538 | Average$805 | FlexibilityNo cancel fee | On-time71% |