$248+ Cheap flights from St. Louis (STL) to Santo Domingo (SDQ)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SDQ
Nov 16 — Nov 231
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Santo Domingo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Santo Domingo
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Cheapest flights from St. Louis to Santo DomingoExplore the most affordable flight options available from St. Louis to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 17, 2026.
Explore the most affordable flight options available from St. Louis to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 17, 2026.
This FlightHub deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:13 pm -
1 stop18h 27m
Tue 12/81:27 pm -
2 stops23h 50m
Deal found 10/13![Frontier logo]()
$493
This Mytrip deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/212:02 pm -
2 stops22h 02m
Tue 12/83:35 pm -
3 stops21h 42m
Deal found 10/13![Multiple Airlines logo]()
$558
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/24:48 pm -
1 stop15h 17m
Tue 12/812:59 pm -
1 stop10h 50m
Deal found 10/13![American Airlines logo]()
$645
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:15 pm -
1 stop13h 50m
Mon 12/72:22 pm -
1 stop8h 24m
Deal found 10/13![American Airlines logo]()
$660
This FlightHub deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/245:58 pm -
2 stops45h 35m
Sun 12/273:26 pm -
2 stops21h 27m
Deal found 10/16![Frontier logo]()
$720
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/267:15 pm -
1 stop15h 21m
Wed 12/303:35 am -
2 stops20h 06m
Deal found 10/14![Delta logo]()
$725
Best flights from St. Louis to Santo DomingoDiscover carefully curated flight deals from St. Louis to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 17, 2026.
Discover carefully curated flight deals from St. Louis to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 17, 2026.
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:15 pm -
1 stop13h 50m
Mon 12/72:22 pm -
1 stop8h 24m
Deal found 10/13![American Airlines logo]()
$660
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/96:05 am -
1 stop15h 41m
Sat 1/162:53 pm -
1 stop8h 59m
Deal found 10/16![United Airlines logo]()
$814
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/236:21 pm -
2 stops26h 51m
Thu 1/72:36 pm -
1 stop21h 45m
Deal found 10/16![Multiple Airlines logo]()
$858
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/154:25 pm -
2 stops15h 33m
Mon 3/224:06 pm -
1 stop20h 12m
Deal found 10/15![American Airlines logo]()
$700
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/245:59 pm -
1 stop26h 46m
Sun 12/272:50 am -
2 stops18h 12m
Deal found 10/14![United Airlines logo]()
$832
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/256:06 am -
1 stop15h 40m
Thu 1/282:53 pm -
1 stop8h 56m
Deal found 10/13![United Airlines logo]()
$880
Last-minute flights from St. Louis to Santo DomingoDiscover last-minute flight deals from St. Louis to Santo Domingo. Data last updated October 17, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Santo Domingo. Data last updated October 17, 2026 and is based on user searches.
This Mytrip deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:35 pm -
3 stops26h 10m
Fri 10/3010:19 am -
3 stops33h 55m
Deal found 10/14![Multiple Airlines logo]()
$875
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:00 am -
1 stop6h 32m
Fri 10/302:57 pm -
1 stop9h 57m
Deal found 10/14![Delta logo]()
$880
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:07 pm -
1 stop14h 15m
Mon 11/96:00 am -
1 stop13h 25m
Deal found 10/13![American Airlines logo]()
$795
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/285:00 am -
1 stop8h 51m
Sat 12/511:09 am -
1 stop12h 40m
Deal found 10/14![American Airlines logo]()
$680
One-way flights from St. Louis to Santo DomingoSearch for one-way flight options from St. Louis to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated October 17, 2026.
Search for one-way flight options from St. Louis to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated October 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:34 pm -
2 stops25h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Multiple Airlines logo]()
$248
This Priceline deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/315:58 pm -
1 stop18h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Frontier logo]()
$249
This Priceline deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/305:58 pm -
1 stop18h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Frontier logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:21 pm -
2 stops26h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Multiple Airlines logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:35 pm -
2 stops25h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/13![Multiple Airlines logo]()
$277
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:34 pm -
2 stops26h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Multiple Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/315:58 pm -
3 stops52h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Multiple Airlines logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:24 pm -
3 stops45h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Multiple Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/239:59 am -
1 stop11h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/13![United Airlines logo]()
$363
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/179:59 am -
1 stop11h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![United Airlines logo]()
$373
Find flight deals from St. Louis to Santo Domingo
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $493 (FlightHub) |
One-way from | $248 (Kiwi.com) |
Popular in | December |
Cheapest in | January |
Average price | $696 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 17, 2026.
Use the filters below to find and compare flights from St. Louis to Santo Domingo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Wed 12/30
6:21 pm-11:12 pm
2 stops26h 51m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$265
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Mon 11/23
6:35 pm-9:45 pm
2 stops25h 10m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$277
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Thu 12/31
5:58 pm-12:32 am
3 stops52h 34m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$330
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Mon 11/23
9:59 am-11:46 pm
1 stop11h 47m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$363
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Tue 11/17
6:40 am-7:30 pm
2 stops10h 50m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$373
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Tue 11/17
9:59 am-11:46 pm
1 stop11h 47m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$373
Quickest round-trip
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Sun 11/15
6:00 am-2:32 pm
1 stop6h 32m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$373
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Thu 11/19
6:00 am-2:32 pm
1 stop6h 32m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$393
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Tue 12/29
6:00 am-9:51 pm
2 stops13h 51m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$429
St. LouisSanto Domingo
STL Lambert-St Louis - SDQ Santo Domingo Las Americas
STLSDQ
Lambert-St Louis
Thu 10/22
5:00 am-8:50 pm
1 stop14h 50m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$448
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Santo Domingo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santo Domingo in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on St. Louis-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Santo Domingo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Santo Domingo
Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from St. Louis with our price prediction graph.
STL-SDQ
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Santo Domingo
Reviews of airlines servicing Santo Domingo
Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated October 17, 2026.
Read through reviews of airlines operating flights from St. Louis to Santo Domingo, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Crew
7.9
Food
6.4
Overall
7.0
Boarding
7.4
Comfort
7.2
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Entertainment
6.8
Crew
7.9
Food
6.4
Overall
7.0
Boarding
7.4
Comfort
7.2
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santo Domingo?
Book flights to Santo Domingo if you plan to visit one of these locationsJuan Dolio
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Complete your trip
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St. Louis and Santo Domingo flights
Browse other St. Louis and Santo Domingo flight options. Last updated on October 17, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on October 17, 2026.
Popular flight searches
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Other flights to Santo Domingo
Explore flights to Santo Domingo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 17, 2026.
Top airline flying from St. Louis to Santo Domingo
Discover the top airline that operate flights from St. Louis to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$538 | Average$782 | FlexibilityNo cancel fee | On-time71% |