$207+ Cheap flights from St. Louis (STL) to Santo Domingo (SDQ)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/10. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SDQ
Aug 26 — Sep 21
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Santo Domingo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Santo Domingo
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Cheapest flights from St. Louis to Santo DomingoExplore the most affordable flight options available from St. Louis to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 27, 2026.
Explore the most affordable flight options available from St. Louis to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 27, 2026.
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:05 am
STL
- SDQ
1 stop17h 49m
Delta
Tue 9/12:53 pm
SDQ
- STL
1 stop9h 28m
Delta
Deal found 7/27![Delta logo]()
$591
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:42 pm
STL
- SDQ
1 stop18h 18m
American Airlines
Thu 9/102:15 pm
SDQ
- STL
1 stop10h 44m
American Airlines
Deal found 7/26![American Airlines logo]()
$600
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:00 am
STL
- SDQ
2 stops11h 44m
American Airlines
Tue 9/110:27 am
SDQ
- STL
2 stops12h 09m
American Airlines
Deal found 7/27![American Airlines logo]()
$610
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/245:00 am
STL
- SDQ
1 stop12h 34m
American Airlines
Sun 9/2710:21 am
SDQ
- STL
1 stop14h 38m
American Airlines
Deal found 7/26![American Airlines logo]()
$625
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:00 am
STL
- SDQ
1 stop7h 11m
American Airlines
Sat 9/194:20 pm
SDQ
- STL
1 stop8h 39m
American Airlines
Deal found 7/26![American Airlines logo]()
$640
This CheapOair deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/124:57 pm
STL
- SDQ
2 stops41h 06m
Frontier
Sun 8/1612:55 pm
SDQ
- STL
2 stops31h 28m
Frontier
Deal found 7/23![Frontier logo]()
$643
This FlightHub deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/88:08 pm
STL
- SDQ
2 stops14h 37m
Frontier
Sun 8/1612:55 pm
SDQ
- STL
2 stops21h 02m
Frontier
Deal found 7/22![Frontier logo]()
$647
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:07 pm
STL
- SDQ
2 stops18h 17m
American Airlines
Tue 8/254:24 pm
SDQ
- STL
1 stop7h 16m
American Airlines
Deal found 7/23![American Airlines logo]()
$650
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:45 pm
STL
- SDQ
1 stop18h 15m
American Airlines
Mon 8/242:22 pm
SDQ
- STL
1 stop9h 18m
American Airlines
Deal found 7/26![American Airlines logo]()
$670
Best flights from St. Louis to Santo DomingoDiscover carefully curated flight deals from St. Louis to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 27, 2026.
Discover carefully curated flight deals from St. Louis to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 27, 2026.
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:05 am
STL
- SDQ
1 stop17h 49m
Delta
Tue 9/12:53 pm
SDQ
- STL
1 stop9h 28m
Delta
Deal found 7/27![Delta logo]()
$591
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/245:00 am
STL
- SDQ
1 stop9h 17m
American Airlines
Sun 9/277:34 pm
SDQ
- STL
2 stops18h 29m
American Airlines
Deal found 7/26![American Airlines logo]()
$630
This United Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/277:30 am
STL
- SDQ
1 stop14h 16m
United Airlines
Thu 10/16:00 am
SDQ
- STL
1 stop16h 09m
United Airlines
Deal found 7/23![United Airlines logo]()
$820
This Delta deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:00 am
STL
- SDQ
1 stop6h 28m
Delta
Fri 9/112:53 pm
SDQ
- STL
1 stop9h 49m
Delta
Deal found 7/24![Delta logo]()
$600
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/236:25 pm
STL
- SDQ
2 stops17h 57m
American Airlines
Sun 8/304:24 pm
SDQ
- STL
1 stop7h 16m
American Airlines
Deal found 7/26![American Airlines logo]()
$650
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:00 am
STL
- SDQ
2 stops11h 19m
American Airlines
Mon 3/111:02 am
SDQ
- STL
2 stops12h 29m
American Airlines
Deal found 7/22![American Airlines logo]()
$685
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:01 am
STL
- SDQ
1 stop15h 45m
United Airlines
Sat 8/153:20 pm
SDQ
- STL
1 stop9h 18m
United Airlines
Deal found 7/24![United Airlines logo]()
$822
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:42 pm
STL
- SDQ
1 stop18h 18m
American Airlines
Sun 8/167:00 am
SDQ
- STL
1 stop16h 40m
American Airlines
Deal found 7/22![American Airlines logo]()
$815
Last-minute flights from St. Louis to Santo DomingoDiscover last-minute flight deals from St. Louis to Santo Domingo. Data last updated July 27, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Santo Domingo. Data last updated July 27, 2026 and is based on user searches.
This FlightHub deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/88:08 pm
STL
- SDQ
2 stops14h 37m
Frontier
Sun 8/1612:55 pm
SDQ
- STL
2 stops21h 02m
Frontier
Deal found 7/22![Frontier logo]()
$647
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/105:42 pm
STL
- SDQ
1 stop18h 18m
American Airlines
Thu 8/274:24 pm
SDQ
- STL
1 stop7h 16m
American Airlines
Deal found 7/23![American Airlines logo]()
$690
This CheapOair deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/124:57 pm
STL
- SDQ
2 stops41h 06m
Frontier
Sun 8/1612:55 pm
SDQ
- STL
2 stops31h 28m
Frontier
Deal found 7/23![Frontier logo]()
$643
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:42 pm
STL
- SDQ
1 stop18h 18m
American Airlines
Tue 8/252:22 pm
SDQ
- STL
1 stop9h 18m
American Airlines
Deal found 7/23![American Airlines logo]()
$645
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:45 pm
STL
- SDQ
1 stop18h 15m
American Airlines
Mon 8/242:22 pm
SDQ
- STL
1 stop9h 18m
American Airlines
Deal found 7/26![American Airlines logo]()
$670
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:00 am
STL
- SDQ
2 stops17h 54m
Delta
Tue 9/12:53 pm
SDQ
- STL
1 stop9h 28m
Delta
Deal found 7/27![Delta logo]()
$591
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:00 am
STL
- SDQ
2 stops11h 44m
American Airlines
Tue 9/110:27 am
SDQ
- STL
2 stops12h 09m
American Airlines
Deal found 7/27![American Airlines logo]()
$610
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:42 pm
STL
- SDQ
1 stop18h 18m
American Airlines
Thu 9/102:15 pm
SDQ
- STL
1 stop10h 44m
American Airlines
Deal found 7/26![American Airlines logo]()
$600
One-way flights from St. Louis to Santo DomingoSearch for one-way flight options from St. Louis to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated July 27, 2026.
Search for one-way flight options from St. Louis to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated July 27, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1010:35 am
STL
- SDQ
3 stops55h 14m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:17 pm
STL
- SDQ
2 stops26h 28m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1110:35 am
STL
- SDQ
2 stops28h 54m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$235
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/315:42 pm
STL
- SDQ
1 stop18h 18m
American Airlines
Deal found 7/25![American Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:07 pm
STL
- SDQ
1 stop14h 15m
American Airlines
Deal found 7/23![American Airlines logo]()
$363
Find flight deals from St. Louis to Santo Domingo
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 27, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $600 (American Airlines) |
One-way from | $207 (Kiwi.com) |
Popular in | May |
Cheapest in | September |
Average price | $782 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 27, 2026.
Use the filters below to find and compare flights from St. Louis to Santo Domingo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSanto Domingo
STL - SDQ
STLSDQ
Lambert-St Louis
Mon 8/24
6:05 am-12:54 am
1 stop17h 49m
Santo Domingo Las Americas
Tue 9/1
2:53 pm-11:21 pm
1 stop9h 28m
$591
Quickest round-trip
St. LouisSanto Domingo
STL - SDQ
STLSDQ
Lambert-St Louis
Wed 9/2
6:00 am-1:28 pm
1 stop6h 28m
Santo Domingo Las Americas
Fri 9/11
2:53 pm-11:42 pm
1 stop9h 49m
$600
St. LouisSanto Domingo
STL - SDQ
STLSDQ
Lambert-St Louis
Thu 9/24
5:00 am-3:17 pm
1 stop9h 17m
Santo Domingo Las Americas
Sun 9/27
7:34 pm-1:03 pm
2 stops18h 29m
$630
St. LouisSanto Domingo
STL - SDQ
STLSDQ
Lambert-St Louis
Sun 8/23
6:25 pm-1:22 pm
2 stops17h 57m
Santo Domingo Las Americas
Sun 8/30
4:24 pm-10:40 pm
1 stop7h 16m
$650
St. LouisSanto Domingo
STL - SDQ
STLSDQ
Lambert-St Louis
Sun 11/1
5:00 am-6:19 pm
2 stops11h 19m
Santo Domingo Las Americas
Mon 3/1
11:02 am-9:31 pm
2 stops12h 29m
$685
St. LouisSanto Domingo
STL - SDQ
STLSDQ
Lambert-St Louis
Sat 8/8
5:42 pm-1:00 pm
1 stop18h 18m
Santo Domingo Las Americas
Sun 8/16
7:00 am-10:40 pm
1 stop16h 40m
$815
St. LouisSanto Domingo
STL - SDQ
STLSDQ
Lambert-St Louis
Sun 9/27
7:30 am-10:46 pm
1 stop14h 16m
Santo Domingo Las Americas
Thu 10/1
6:00 am-9:09 pm
1 stop16h 09m
$820
St. LouisSanto Domingo
STL - SDQ
STLSDQ
Lambert-St Louis
Sun 8/9
6:01 am-10:46 pm
1 stop15h 45m
Santo Domingo Las Americas
Sat 8/15
3:20 pm-11:38 pm
1 stop9h 18m
$822
Cheapest one-way
St. LouisSanto Domingo
STL - SDQ
STLSDQ
Lambert-St Louis
Sat 10/10
10:35 am-6:49 pm
3 stops55h 14m
$207
St. LouisSanto Domingo
STL - SDQ
STLSDQ
Lambert-St Louis
Mon 8/31
6:17 pm-9:45 pm
2 stops26h 28m
$225
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Santo Domingo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santo Domingo in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on St. Louis-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Santo Domingo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Santo Domingo
Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from St. Louis with our price prediction graph.
STL-SDQ
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Santo Domingo
What is the cheapest month to book a flight from St. Louis to Santo Domingo?
Currently, September is the cheapest month in which you can book a flight from St. Louis to Santo Domingo (average of $574). Flying from St. Louis to Santo Domingo in May is currently the most expensive (average of $833). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Santo Domingo?
Airfare is below average for this route at the moment.
St. Louis to Santo Domingo flights typically cost between $600 and $670 in August.The cheapest round-trip price found within the last 5 days was $591 on Delta (Aug 24-Sep 1).
Reviews of airlines servicing Santo Domingo
Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated July 27, 2026.
Read through reviews of airlines operating flights from St. Louis to Santo Domingo, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
7.8
Entertainment
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.8
Entertainment
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.8
Entertainment
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santo Domingo?
Book flights to Santo Domingo if you plan to visit one of these locationsJuan Dolio
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Complete your trip
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St. Louis and Santo Domingo flights
Browse other St. Louis and Santo Domingo flight options. Last updated on July 27, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on July 27, 2026.
Popular flight searches
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Other flights to Santo Domingo
Explore flights to Santo Domingo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 27, 2026.
Top 2 airlines flying from St. Louis to Santo Domingo
Discover the top 2 airlines that operate flights from St. Louis to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$524 | Average$603 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$529 | Average$700 | FlexibilityNo cancel fee | On-time71% |