$343+ Cheap flights from St. Louis (STL) to Santiago de los Caballeros (STI)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/8. Fares are subject to change and may not be available on all flights or dates of travel.
STL — STI
Jun 11 — Jun 181
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Santiago de los Caballeros with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Santiago de los Caballeros
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to Santiago de los CaballerosExplore the most affordable flight options available from St. Louis to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 12, 2026.
Explore the most affordable flight options available from St. Louis to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 12, 2026.
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/2411:15 am
STL
- STI
1 stop8h 57m
American Airlines
Wed 7/19:07 am
STI
- STL
1 stop14h 50m
American Airlines
Deal found 5/10![American Airlines logo]()
$590
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:15 am
STL
- STI
1 stop14h 58m
American Airlines
Tue 6/91:14 pm
STI
- STL
1 stop11h 45m
American Airlines
Deal found 5/11![American Airlines logo]()
$635
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/146:53 pm
STL
- STI
2 stops18h 39m
American Airlines
Thu 1/76:02 am
STI
- STL
2 stops10h 55m
American Airlines
Deal found 5/11![American Airlines logo]()
$645
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:40 pm
STL
- STI
1 stop17h 41m
American Airlines
Fri 6/263:39 pm
STI
- STL
1 stop8h 18m
American Airlines
Deal found 5/9![American Airlines logo]()
$655
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:40 pm
STL
- STI
1 stop17h 32m
American Airlines
Mon 6/157:04 am
STI
- STL
1 stop16h 53m
American Airlines
Deal found 5/10![American Airlines logo]()
$675
Best flights from St. Louis to Santiago de los CaballerosDiscover carefully curated flight deals from St. Louis to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 12, 2026.
Discover carefully curated flight deals from St. Louis to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 12, 2026.
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:16 am
STL
- STI
1 stop14h 56m
American Airlines
Wed 7/19:07 am
STI
- STL
2 stops15h 52m
American Airlines
Deal found 5/10![American Airlines logo]()
$595
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:00 am
STL
- STI
2 stops18h 59m
Delta
Mon 6/158:59 pm
STI
- STL
2 stops16h 35m
Delta
Deal found 5/10![Delta logo]()
$660
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:25 am
STL
- STI
2 stops14h 48m
American Airlines
Tue 6/99:07 am
STI
- STL
2 stops15h 52m
American Airlines
Deal found 5/9![American Airlines logo]()
$640
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:40 pm
STL
- STI
1 stop17h 41m
American Airlines
Fri 6/267:04 am
STI
- STL
1 stop16h 53m
American Airlines
Deal found 5/8![American Airlines logo]()
$655
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:40 pm
STL
- STI
1 stop17h 32m
American Airlines
Mon 6/157:04 am
STI
- STL
1 stop16h 53m
American Airlines
Deal found 5/10![American Airlines logo]()
$675
Last-minute flights from St. Louis to Santiago de los CaballerosDiscover last-minute flight deals from St. Louis to Santiago de los Caballeros. Data last updated May 12, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Santiago de los Caballeros. Data last updated May 12, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:40 pm
STL
- STI
1 stop17h 41m
American Airlines
Fri 6/263:39 pm
STI
- STL
1 stop8h 18m
American Airlines
Deal found 5/9![American Airlines logo]()
$655
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:15 am
STL
- STI
1 stop14h 58m
American Airlines
Tue 6/91:14 pm
STI
- STL
1 stop11h 45m
American Airlines
Deal found 5/11![American Airlines logo]()
$635
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:15 am
STL
- STI
1 stop8h 23m
American Airlines
Sat 6/271:15 pm
STI
- STL
1 stop22h 22m
American Airlines
Deal found 5/8![American Airlines logo]()
$696
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:40 pm
STL
- STI
1 stop17h 32m
American Airlines
Mon 6/157:04 am
STI
- STL
1 stop16h 53m
American Airlines
Deal found 5/10![American Airlines logo]()
$675
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/2411:15 am
STL
- STI
1 stop8h 57m
American Airlines
Wed 7/19:07 am
STI
- STL
1 stop14h 50m
American Airlines
Deal found 5/10![American Airlines logo]()
$590
One-way flights from St. Louis to Santiago de los CaballerosSearch for one-way flight options from St. Louis to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated May 12, 2026.
Search for one-way flight options from St. Louis to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated May 12, 2026.
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:00 am
STL
- STI
1 stop15h 52m
United Airlines
Deal found 5/9![United Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:29 am
STL
- STI
2 stops14h 43m
American Airlines
Deal found 5/9![American Airlines logo]()
$363
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/76:00 am
STL
- STI
1 stop15h 52m
United Airlines
Deal found 5/9![United Airlines logo]()
$368
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/76:13 pm
STL
- STI
2 stops19h 24m
American Airlines
Deal found 5/9![American Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/76:00 am
STL
- STI
2 stops18h 59m
Delta
Deal found 5/11![Delta logo]()
$388
This Delta deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:00 am
STL
- STI
2 stops12h 28m
Delta
Deal found 5/7![Delta logo]()
$408
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/314:25 pm
STL
- STI
1 stop7h 34m
Delta
Deal found 5/11![Delta logo]()
$433
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:00 am
STL
- STI
2 stops14h 13m
American Airlines
Deal found 5/11![American Airlines logo]()
$451
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/313:30 pm
STL
- STI
3 stops22h 29m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$631
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/74:19 pm
STL
- STI
3 stops21h 40m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$650
Find flight deals from St. Louis to Santiago de los Caballeros
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago de los Caballeros (STI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $590 (American Airlines) |
One-way from | $343 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 12, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago de los Caballeros that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Wed 6/24
5:16 am-9:12 pm
1 stop14h 56m
Santiago de los Caballeros
Wed 7/1
9:07 am-11:59 pm
2 stops15h 52m
$595
Quickest round-trip
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Tue 6/2
5:25 am-9:13 pm
2 stops14h 48m
Santiago de los Caballeros
Tue 6/9
9:07 am-11:59 pm
2 stops15h 52m
$640
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Sat 5/30
5:40 pm-12:21 pm
1 stop17h 41m
Santiago de los Caballeros
Fri 6/26
7:04 am-10:57 pm
1 stop16h 53m
$655
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Mon 6/8
6:00 am-1:59 am
2 stops18h 59m
Santiago de los Caballeros
Mon 6/15
8:59 pm-12:34 pm
2 stops16h 35m
$660
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Mon 6/8
5:40 pm-12:12 pm
1 stop17h 32m
Santiago de los Caballeros
Mon 6/15
7:04 am-10:57 pm
1 stop16h 53m
$675
Cheapest one-way
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Mon 6/8
6:00 am-10:52 pm
1 stop15h 52m
$343
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Mon 6/8
5:29 am-9:12 pm
2 stops14h 43m
$363
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Sun 6/7
6:13 pm-2:37 pm
2 stops19h 24m
$369
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Sun 6/7
6:00 am-1:59 am
2 stops18h 59m
$388
St. LouisSantiago de los Caballeros
STL - STI
STLSTI
Lambert-St Louis
Fri 5/29
6:00 am-7:28 pm
2 stops12h 28m
$408
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Santiago de los Caballeros
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago de los Caballeros in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Santiago de los Caballeros flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Santiago de los Caballeros flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago de los Caballeros flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Santiago de los Caballeros flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago de los Caballeros flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Santiago de los Caballeros
Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from St. Louis with our price prediction graph.
STL-STI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Santiago de los Caballeros
Get insights into the airlines that provide service to Santiago de los Caballeros. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago de los Caballeros. Reviews last updated May 12, 2026.
Get a feel of what it's like to fly with United Airlines from St. Louis to Santiago de los Caballeros by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.1
Comfort
7.3
Overall
7.4
Boarding
7.7
Crew
8.1
Food
6.6
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Entertainment
7.1
Comfort
7.3
Overall
7.4
Boarding
7.7
Crew
8.1
Food
6.6
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Santiago de los Caballeros flight routes
Alternative routes for St. Louis to Santiago de los Caballeros
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Complete your trip
Complete your trip to Santiago de los Caballeros by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Santiago de los Caballeros by cabin class
Find flights from St. Louis to Santiago de los Caballeros, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Santiago de los Caballeros flights
Browse other St. Louis and Santiago de los Caballeros flight options. Last updated on May 12, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on May 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago de los Caballeros
Explore flights to Santiago de los Caballeros departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 12, 2026.
Top airline flying from St. Louis to Santiago de los Caballeros
Discover the top airline that operate flights from St. Louis to Santiago de los Caballeros. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$538 | Average$609 | FlexibilityNo cancel fee | On-time69% |