$446+ Cheap flights from St. Louis (STL) to Santiago de los Caballeros (STI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/29. Fares are subject to change and may not be available on all flights or dates of travel.
STL — STI
Oct 23 — Oct 301
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Santiago de los Caballeros with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Santiago de los Caballeros
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Best
Last-minute
One-way
Cheapest flights from St. Louis to Santiago de los CaballerosExplore the most affordable flight options available from St. Louis to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2026.
Explore the most affordable flight options available from St. Louis to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2026.
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/39:59 am -
1 stop11h 52m
Tue 11/106:00 am -
1 stop12h 17m
Deal found 9/19![United Airlines logo]()
$620
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:00 am -
2 stops10h 33m
Tue 11/109:25 pm -
2 stops17h 58m
Deal found 9/19![Delta logo]()
$625
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am -
1 stop15h 51m
Sat 11/74:00 pm -
1 stop8h 54m
Deal found 9/21![United Airlines logo]()
$760
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/58:15 pm -
2 stops15h 11m
Sat 11/72:16 pm -
1 stop9h 31m
Deal found 9/21![American Airlines logo]()
$765
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/199:30 am -
1 stop12h 22m
Thu 10/226:00 am -
1 stop11h 00m
Deal found 9/21![United Airlines logo]()
$870
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/216:00 am -
2 stops13h 57m
Wed 1/137:20 am -
2 stops16h 35m
Deal found 9/22![American Airlines logo]()
$877
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:30 am -
1 stop14h 22m
Wed 10/144:23 pm -
1 stop17h 25m
Deal found 9/19![United Airlines logo]()
$960
Best flights from St. Louis to Santiago de los CaballerosDiscover carefully curated flight deals from St. Louis to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 23, 2026.
Discover carefully curated flight deals from St. Louis to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 23, 2026.
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/39:59 am -
1 stop11h 52m
Tue 11/106:00 am -
1 stop12h 17m
Deal found 9/19![United Airlines logo]()
$620
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:00 am -
2 stops10h 33m
Tue 11/109:25 pm -
2 stops17h 58m
Deal found 9/19![Delta logo]()
$625
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/175:00 am -
1 stop14h 29m
Sat 1/232:12 pm -
1 stop11h 34m
Deal found 9/21![American Airlines logo]()
$748
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:30 am -
2 stops14h 21m
Wed 11/1112:55 pm -
1 stop10h 57m
Deal found 9/20![United Airlines logo]()
$625
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/179:22 am -
2 stops12h 29m
Sat 1/236:00 am -
1 stop12h 13m
Deal found 9/21![United Airlines logo]()
$744
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am -
1 stop15h 51m
Sat 11/74:00 pm -
1 stop8h 54m
Deal found 9/21![United Airlines logo]()
$760
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/199:30 am -
1 stop12h 22m
Thu 10/226:00 am -
1 stop11h 00m
Deal found 9/21![United Airlines logo]()
$870
Last-minute flights from St. Louis to Santiago de los CaballerosDiscover last-minute flight deals from St. Louis to Santiago de los Caballeros. Data last updated September 23, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Santiago de los Caballeros. Data last updated September 23, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:30 am -
1 stop14h 22m
Wed 10/144:23 pm -
1 stop17h 25m
Deal found 9/19![United Airlines logo]()
$960
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/199:30 am -
1 stop12h 22m
Thu 10/226:00 am -
1 stop11h 00m
Deal found 9/21![United Airlines logo]()
$870
One-way flights from St. Louis to Santiago de los CaballerosSearch for one-way flight options from St. Louis to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated September 23, 2026.
Search for one-way flight options from St. Louis to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated September 23, 2026.
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/294:32 pm -
2 stops27h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![American Airlines logo]()
$446
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/288:22 pm -
2 stops17h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![American Airlines logo]()
$511
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2410:12 am -
2 stops33h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![American Airlines logo]()
$547
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/271:51 pm -
2 stops24h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![American Airlines logo]()
$612
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/225:03 am -
1 stop13h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![American Airlines logo]()
$636
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/232:59 pm -
3 stops21h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Multiple Airlines logo]()
$646
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/236:19 pm -
1 stop19h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![American Airlines logo]()
$647
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/233:00 pm -
2 stops21h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![United Airlines logo]()
$657
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/266:58 pm -
2 stops17h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![United Airlines logo]()
$704
Find flight deals from St. Louis to Santiago de los Caballeros
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago de los Caballeros (STI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 23, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $620 (United Airlines) |
One-way from | $446 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Santiago de los Caballeros that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 23, 2026.
Use the filters below to find and compare flights from St. Louis to Santiago de los Caballeros that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSantiago de los Caballeros
STL Lambert-St Louis - STI Santiago de los Caballeros
STLSTI
Lambert-St Louis
Mon 12/28
8:22 pm-4:15 pm
2 stops17h 53m
Santiago de los Caballeros
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$511
St. LouisSantiago de los Caballeros
STL Lambert-St Louis - STI Santiago de los Caballeros
STLSTI
Lambert-St Louis
Tue 11/3
9:59 am-11:51 pm
1 stop11h 52m
Santiago de los Caballeros
Tue 11/10
6:00 am-4:17 pm
1 stop12h 17m
$620
St. LouisSantiago de los Caballeros
STL Lambert-St Louis - STI Santiago de los Caballeros
STLSTI
Lambert-St Louis
Tue 11/3
6:00 am-6:33 pm
2 stops10h 33m
Santiago de los Caballeros
Tue 11/10
9:25 pm-1:23 pm
2 stops17h 58m
$625
St. LouisSantiago de los Caballeros
STL Lambert-St Louis - STI Santiago de los Caballeros
STLSTI
Lambert-St Louis
Wed 11/4
7:30 am-11:51 pm
2 stops14h 21m
Santiago de los Caballeros
Wed 11/11
12:55 pm-9:52 pm
1 stop10h 57m
$625
St. LouisSantiago de los Caballeros
STL Lambert-St Louis - STI Santiago de los Caballeros
STLSTI
Lambert-St Louis
Tue 12/22
6:00 am-8:50 pm
2 stops12h 50m
Santiago de los Caballeros
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$636
St. LouisSantiago de los Caballeros
STL Lambert-St Louis - STI Santiago de los Caballeros
STLSTI
Lambert-St Louis
Wed 12/23
2:59 pm-2:58 pm
3 stops21h 59m
Santiago de los Caballeros
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$646
St. LouisSantiago de los Caballeros
STL Lambert-St Louis - STI Santiago de los Caballeros
STLSTI
Lambert-St Louis
Wed 12/23
6:19 pm-4:15 pm
1 stop19h 56m
Santiago de los Caballeros
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$647
St. LouisSantiago de los Caballeros
STL Lambert-St Louis - STI Santiago de los Caballeros
STLSTI
Lambert-St Louis
Wed 12/23
3:00 pm-2:53 pm
2 stops21h 53m
Santiago de los Caballeros
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$657
St. LouisSantiago de los Caballeros
STL Lambert-St Louis - STI Santiago de los Caballeros
STLSTI
Lambert-St Louis
Fri 12/25
6:04 am-11:51 pm
1 stop15h 47m
Santiago de los Caballeros
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$671
St. LouisSantiago de los Caballeros
STL Lambert-St Louis - STI Santiago de los Caballeros
STLSTI
Lambert-St Louis
Sat 12/26
6:58 pm-2:53 pm
2 stops17h 55m
Santiago de los Caballeros
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$704
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Santiago de los Caballeros
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santiago de los Caballeros in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Santiago de los Caballeros flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on St. Louis-Santiago de los Caballeros flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from St. Louis-Santiago de los Caballeros flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Santiago de los Caballeros flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santiago de los Caballeros flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Santiago de los Caballeros
Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from St. Louis with our price prediction graph.
STL-STI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Santiago de los Caballeros
Get insights into the airlines that provide service to Santiago de los Caballeros. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago de los Caballeros. Reviews last updated September 23, 2026.
Get a feel of what it's like to fly with United Airlines and American Airlines from St. Louis to Santiago de los Caballeros by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.7
Food
6.7
Crew
8.1
Overall
7.4
Entertainment
7.1
Comfort
7.3
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Boarding
7.7
Food
6.7
Crew
8.1
Overall
7.4
Entertainment
7.1
Comfort
7.3
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Boarding
7.7
Food
6.7
Crew
8.1
Overall
7.4
Entertainment
7.1
Comfort
7.3
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for St. Louis to Santiago de los Caballeros
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Complete your trip
Complete your trip to Santiago de los Caballeros by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Santiago de los Caballeros by cabin class
Find flights from St. Louis to Santiago de los Caballeros, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Santiago de los Caballeros flights
Browse other St. Louis and Santiago de los Caballeros flight options. Last updated on September 23, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on September 23, 2026.
Popular flight searches
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Other flights to Santiago de los Caballeros
Explore flights to Santiago de los Caballeros departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 23, 2026.
Top 2 airlines flying from St. Louis to Santiago de los Caballeros
Discover the top 2 airlines that operate flights from St. Louis to Santiago de los Caballeros. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$538 | Average$690 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$600 | Average$640 | FlexibilityNo cancel fee | On-time71% |