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$283+ Cheap flights from San Francisco (SFO) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — SCL
nov. 26 — dic. 31
mié. 11/26
mié. 12/3
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

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Cheapflights Tip: The best prices from San Francisco to Santiago Arturo Merino Benitez are usually found in October or August, booked 70 days in advance, depart on a Wednesday or Monday and return on a Saturday

Find flight deals from San Francisco to Santiago

Cheapest flights from San Francisco to Santiago
Explore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 27, 2025.

This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/199:10 amSFO - SCL
1 stop18h 40mUnited Airlines
vie. 12/510:45 pmSCL - SFO
1 stop23h 01mUnited Airlines
Deal found 10/26$529
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/155:15 amSFO - SCL
1 stop22h 35mUnited Airlines
mié. 12/310:45 pmSCL - SFO
1 stop21h 09mUnited Airlines
Deal found 10/25$534
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/39:00 amSFO - SCL
2 stops18h 10mAmerican Airlines
sáb. 12/1311:15 pmSCL - SFO
2 stops20h 40mAmerican Airlines
Deal found 10/26$539
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/112:43 amSFO - SCL
1 stop27h 07mUnited Airlines
vie. 12/2610:45 pmSCL - SFO
1 stop30h 36mUnited Airlines
Deal found 10/26$540
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/212:43 amSFO - SCL
1 stop27h 07mUnited Airlines
sáb. 12/1310:45 pmSCL - SFO
1 stop18h 24mUnited Airlines
Deal found 10/27$543
This deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/121:00 pmSFO - SCL
1 stop14h 50mUnited Airlines
mié. 12/310:45 pmSCL - SFO
1 stop18h 24mUnited Airlines
Deal found 10/27$544
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/57:10 amSFO - SCL
2 stops20h 50mAmerican Airlines
lun. 11/1710:25 pmSCL - SFO
2 stops20h 04mAmerican Airlines
Deal found 10/25$549
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/1712:43 amSFO - SCL
1 stop27h 07mUnited Airlines
jue. 11/2710:45 pmSCL - SFO
1 stop18h 25mUnited Airlines
Deal found 10/26$553
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/3110:20 amSFO - SCL
2 stops17h 45mAmerican Airlines
jue. 11/610:25 pmSCL - SFO
2 stops21h 35mAmerican Airlines
Deal found 10/27$554
This Copa Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/812:36 amSFO - SCL
1 stop22h 07mCopa Airlines
lun. 12/153:23 amSCL - SFO
1 stop24h 54mCopa Airlines
Deal found 10/24$557

Cheap flight deals from San Francisco to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated octubre 27, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$518
(American Airlines)

One-way from

$283
(eDestinos)

Popular in

December

Cheapest in

October

Average price

$683
Provider with most accurate pricing for San Francisco-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Francisco-Santiago Arturo Merino Benitez flights.
Search Deals
From San Francisco to Santiago Arturo Merino Benitez
Search Deals
One-way flight from San Francisco to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($94 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($27 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 27, 2025.
Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.

Fly from

San Francisco

Fly to

Santiago

Route

Depart

Return

Price

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mié. 11/19

7:16 am-8:50 am

1 stop20h 34m

Santiago Arturo Merino Benitez

dom. 11/23

10:45 pm-7:25 pm

1 stop25h 40m

$534

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

lun. 12/1

12:43 am-8:50 am

1 stop27h 07m

Santiago Arturo Merino Benitez

vie. 12/26

10:45 pm-12:21 am

1 stop30h 36m

$540

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

vie. 1/30

1:19 pm-8:50 am

1 stop14h 31m

Santiago Arturo Merino Benitez

mié. 2/18

10:45 pm-2:57 pm

1 stop21h 12m

$544

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

sáb. 1/31

4:10 pm-8:50 am

1 stop35h 40m

Santiago Arturo Merino Benitez

jue. 2/12

10:45 pm-12:11 pm

1 stop18h 26m

$544

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

sáb. 1/31

11:59 pm-8:50 am

1 stop27h 51m

Santiago Arturo Merino Benitez

mar. 2/17

10:45 pm-6:50 pm

1 stop25h 05m

$544

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

vie. 11/7

5:15 am-8:50 am

1 stop22h 35m

Santiago Arturo Merino Benitez

jue. 11/13

10:45 pm-7:25 pm

1 stop25h 40m

$544

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

vie. 1/30

1:19 pm-8:50 am

1 stop14h 31m

Santiago Arturo Merino Benitez

jue. 2/12

10:45 pm-12:11 pm

1 stop18h 26m

$544

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

lun. 11/17

12:43 am-8:50 am

1 stop27h 07m

Santiago Arturo Merino Benitez

jue. 11/27

10:45 pm-12:10 pm

1 stop18h 25m

$553

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

lun. 11/17

12:36 am-3:43 am

1 stop22h 07m

Santiago Arturo Merino Benitez

mié. 11/26

3:23 am-11:17 pm

1 stop24h 54m

$592

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

dom. 2/1

11:40 am-7:40 am

1 stop15h 00m

Santiago Arturo Merino Benitez

mié. 2/18

8:15 am-11:51 pm

2 stops20h 36m

$594

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/25

Showing 1-10 of 23 results
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Compare providers for flights from San Francisco to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Santiago in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy3 starsTrust Score*3 stars
SmartFaresPrice Accuracy1 starTrust Score*1 star
Justfly.comPrice Accuracy3 starsTrust Score*3 stars
MytripPrice Accuracy3 starsTrust Score*3 stars
CheapfaremartPrice Accuracy-Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on San Francisco-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Francisco-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Francisco to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santiago

How far ahead should I book a flight from San Francisco to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Santiago. Price data was last updated on October 24, 2025.

Booking 70 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Francisco to Santiago?

Currently, October is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $395). Flying from San Francisco to Santiago in June is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to SCL?

Find hourly flight availability from San Francisco to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 27, 2025.

One of the essential ways to save on airfare from San Francisco to Santiago is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 17% on airfare.

What is the cheapest day to fly from San Francisco to Santiago?

Use this chart to determine the cheapest time to fly round-trip from San Francisco to Santiago. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their San Francisco to Santiago flight should consider departing on Tuesday evenings when fares are most often at their lowest. Tuesday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated octubre 27, 2025.
Peruse reviews from past customers who have flown with Delta, Copa Airlines, and LATAM Airlines from San Francisco to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,996 reviews

Crew

8.5

Boarding

8.2

Overall

7.9

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
7.9
Good
7,996 reviews
Delta
7.9
Good
7,996 reviews

Crew

8.5

Boarding

8.2

Overall

7.9

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.6
Good
1,561 reviews
Delta
7.9
Good
7,996 reviews

Crew

8.5

Boarding

8.2

Overall

7.9

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,872 reviews
Delta
7.9
Good
7,996 reviews

Crew

8.5

Boarding

8.2

Overall

7.9

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,999 reviews
Delta
7.9
Good
7,996 reviews

Crew

8.5

Boarding

8.2

Overall

7.9

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
11,031 reviews
Delta
7.9
Good
7,996 reviews

Crew

8.5

Boarding

8.2

Overall

7.9

Entertainment

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Francisco to Santiago?

    A quick flight from San Francisco to Santiago can take about 20h 34m. United Airlines provides one of the quickest options available for as low as $534. There are 5918 mi between San Francisco and Santiago.

  • What are the cheapest airlines flying from San Francisco to Santiago round-trip?

    Currently priced at $492, Avianca will fly you from San Francisco to Santiago and back. In addition to Avianca, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Copa Airlines and United Airlines - these airlines can fly you to your destination from $510 and $534, respectively. Avianca is currently priced 39% below the average price you’ll pay for this route.

  • Where are the most common layover locations when flying from San Francisco to Santiago?

    Of the flights from San Francisco to Santiago that have layovers, most of them stop in Los Angeles. San Francisco to Santiago flights stop in Houston the next most. Panama City comes next as the third most popular layover location for San Francisco to Santiago flights.

  • What are some popular things to do or see while on a layover in Los Angeles?

    Hollywood Bowl, Hollywood Walk of Fame, and L.A. Live are currently the most popular points of interest in Los Angeles at the moment. Hollywood Bowl, Hollywood Walk of Fame and L.A. Live are located about 12.5 mi, 11.7 mi, and 10.8 mi, respectively from Los Angeles if you are interested in checking them out. Travelers in need of a car in Los Angeles can rent one for about $43 per day.

  • What are some popular points of interest to see during a layover in Houston?

    The majority of Houston visitors spend their time at Space Center Houston, House of Blues Houston, and Revention Music Center. Those on a layover in Houston interested in visiting Space Center Houston, House of Blues Houston, or Revention Music Center can do so by traveling 33.5 mi, 16.1 mi, and 15.5 mi, respectively from Houston George Bush Intcntl. Those looking to explore during their layover in Houston can rent a car from Houston George Bush Intcntl for about $37 per day.

  • What are points of interest worth seeing during a layover in Panama City?

    Most Panama City visitors opt to spend their time at Panama Old Cathedral, Amador Causeway, and Panama Canal. Panama Old Cathedral, Amador Causeway, and Panama Canal can be accessed by traveling approximately 13.2 mi, 14.7 mi, and 15.1 mi, respectively from Panama City Tocumen Intl. Travelers can book a car rental at Panama City Tocumen Intl for about $12 per day to make their sightseeing more efficient.

  • Where are the least popular layover locations for San Francisco to Santiago flights?

    The least popular layover on flights from San Francisco to Santiago is Dallas. Atlanta is the second least popular location for layovers on flights from San Francisco to Santiago.

  • Can I find deals for flights from San Francisco to Santiago that include hotel bookings?

    Yes. In addition to deals on San Francisco to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santiago.

  • Can I find deals for business class flights from San Francisco to Santiago?

    Yes. Cheapflights offers flight deals from San Francisco to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Santiago?

    Currently, October is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $395). Flying from San Francisco to Santiago in June is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for San Francisco to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from San Francisco to Santiago

Discover the top 7 airlines that operate flights from San Francisco to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 27, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$492Average$659FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$510Average$742FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$534Average$811FlexibilityNo cancel feeOn-time69%
DeltaCheapest$594Average$835FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$620Average$913FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$639Average$859FlexibilityNo cancel feeOn-time81%
AeromexicoCheapest$758Average$998FlexibilityNo cancel feeOn-timeN/A

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