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$223+ Cheap flights from San Francisco (SFO) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/6. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — SCL
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from San Francisco to Santiago Arturo Merino Benitez are usually found in September or August, booked 3 days in advance, depart on a Wednesday or Monday and return on a Saturday

Cheap flight deals from San Francisco to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$477
(Cheapflightsfares)

One-way from

$223
(Cheapflightsfares)

Popular in

December

Cheapest in

September

Average price

$698
From San Francisco to Santiago Arturo Merino Benitez
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One-way flight from San Francisco to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 13% potential increase in price ($125 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($39 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from San Francisco to Santiago

Cheapest flights from San Francisco to Santiago
Explore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2012:05 amSFO - SCL
2 stops19h 25mAvianca
Fri 11/74:25 pmSCL - SFO
2 stops35h 55mAvianca
Deal found 9/16$477
This Copa Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1012:36 amSFO - SCL
1 stop21h 48mCopa Airlines
Tue 11/2512:20 pmSCL - SFO
1 stop15h 57mCopa Airlines
Deal found 9/17$482
This Cheapflightsfares deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/162:20 pmSFO - SCL
2 stops29h 10mAvianca
Thu 10/233:30 pmSCL - SFO
2 stops35h 15mAvianca
Deal found 9/16$487
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/49:10 amSFO - SCL
1 stop18h 40mUnited Airlines
Tue 11/1810:45 pmSCL - SFO
1 stop25h 40mUnited Airlines
Deal found 9/16$494
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:00 amSFO - SCL
1 stop19h 45mAmerican Airlines
Mon 12/1511:15 pmSCL - SFO
2 stops19h 18mAmerican Airlines
Deal found 9/16$498
This Copa Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/512:36 amSFO - SCL
1 stop21h 48mCopa Airlines
Fri 11/2112:20 pmSCL - SFO
1 stop15h 57mCopa Airlines
Deal found 9/16$502
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/212:43 amSFO - SCL
1 stop27h 07mUnited Airlines
Mon 11/2410:45 pmSCL - SFO
1 stop16h 00mUnited Airlines
Deal found 9/16$503
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/511:59 pmSFO - SCL
1 stop26h 56mAmerican Airlines
Mon 11/1710:25 pmSCL - SFO
2 stops18h 55mAmerican Airlines
Deal found 9/17$507
This Priceline deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/111:20 pmSFO - SCL
2 stops30h 10mAvianca
Mon 11/241:35 amSCL - SFO
2 stops26h 45mAvianca
Deal found 9/17$527
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:15 amSFO - SCL
1 stop22h 35mUnited Airlines
Wed 11/1210:45 pmSCL - SFO
1 stop18h 25mUnited Airlines
Deal found 9/16$534
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/76:00 amSFO - SCL
1 stop20h 55mAmerican Airlines
Wed 11/1210:25 pmSCL - SFO
2 stops22h 40mAmerican Airlines
Deal found 9/16$538

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.

Fly from

San Francisco

Fly to

Santiago

Route

Depart

Return

Price

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 11/11

9:10 am-8:50 am

1 stop18h 40m

Santiago Arturo Merino Benitez

Tue 11/25

10:45 pm-7:25 pm

1 stop25h 40m

$494

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 2/4

9:06 am-8:50 am

1 stop18h 44m

Santiago Arturo Merino Benitez

Thu 2/12

10:45 pm-12:11 pm

1 stop18h 26m

$544

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 2/2

7:18 am-8:50 am

1 stop20h 32m

Santiago Arturo Merino Benitez

Wed 2/11

10:45 pm-12:11 pm

1 stop18h 26m

$544

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 2/2

7:18 am-8:50 am

1 stop20h 32m

Santiago Arturo Merino Benitez

Thu 2/12

10:45 pm-12:11 pm

1 stop18h 26m

$544

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 2/3

9:06 am-8:50 am

1 stop18h 44m

Santiago Arturo Merino Benitez

Wed 2/11

10:45 pm-5:08 pm

1 stop23h 23m

$544

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 2/1

11:59 pm-8:50 am

1 stop27h 51m

Santiago Arturo Merino Benitez

Mon 2/9

10:45 pm-12:20 pm

1 stop18h 35m

$553

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 2/17

11:59 pm-8:50 am

1 stop27h 51m

Santiago Arturo Merino Benitez

Tue 3/10

9:45 pm-5:05 pm

1 stop23h 20m

$564

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 11/10

12:36 am-8:21 pm

1 stop14h 45m

Santiago Arturo Merino Benitez

Mon 11/24

3:23 am-11:17 pm

1 stop24h 54m

$577

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 2/1

11:59 pm-8:50 am

1 stop27h 51m

Santiago Arturo Merino Benitez

Sat 2/14

10:45 pm-5:54 pm

1 stop24h 09m

$593

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 10/21

7:15 am-6:55 am

2 stops19h 40m

Santiago Arturo Merino Benitez

Thu 11/6

12:55 am-6:56 pm

2 stops23h 01m

$594

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 21 results
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Best time to book a flight from San Francisco to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santiago

How far ahead should I book a flight from San Francisco to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Santiago. Price data was last updated on September 12, 2025.

Booking 3 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Francisco to Santiago?

Currently, April is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $752). Flying from San Francisco to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to SCL?

Find hourly flight availability from San Francisco to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

One of the essential ways to save on airfare from San Francisco to Santiago is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 18% on airfare.

What is the cheapest day to fly from San Francisco to Santiago?

Use this chart to determine the cheapest time to fly round-trip from San Francisco to Santiago. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their San Francisco to Santiago flight should consider departing on Tuesday evenings when fares are most often at their lowest. Saturday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 17, 2025.
Peruse reviews from past customers who have flown with Delta, Copa Airlines, and LATAM Airlines from San Francisco to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.6
Good
1,533 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,849 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Francisco to Santiago?

    A quick flight from San Francisco to Santiago can take about 18h 40m. United Airlines provides one of the quickest options available for as low as $494. There are 5918 mi between San Francisco and Santiago.

  • What are the cheapest airlines flying from San Francisco to Santiago round-trip?

    Currently priced at $492, Avianca will fly you from San Francisco to Santiago and back. In addition to Avianca, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Copa Airlines and United Airlines - these airlines can fly you to your destination from $501 and $593, respectively. Avianca is currently priced 40% below the average price you’ll pay for this route.

  • Where are the most common layover locations when flying from San Francisco to Santiago?

    Of the flights from San Francisco to Santiago that have layovers, most of them stop in Los Angeles. San Francisco to Santiago flights stop in Houston the next most. Panama City comes next as the third most popular layover location for San Francisco to Santiago flights.

  • What are some popular things to do or see while on a layover in Los Angeles?

    Hollywood Bowl, Hollywood Walk of Fame, and The Wiltern are currently the most popular points of interest in Los Angeles at the moment. Hollywood Bowl, Hollywood Walk of Fame and The Wiltern are located about 12.5 mi, 11.7 mi, and 10.0 mi, respectively from Los Angeles if you are interested in checking them out. Travelers in need of a car in Los Angeles can rent one for about $41 per day.

  • What are some popular points of interest to see during a layover in Houston?

    The majority of Houston visitors spend their time at Space Center Houston, House of Blues Houston, and Revention Music Center. Those on a layover in Houston interested in visiting Space Center Houston, House of Blues Houston, or Revention Music Center can do so by traveling 33.5 mi, 16.1 mi, and 15.5 mi, respectively from Houston George Bush Intcntl. Those looking to explore during their layover in Houston can rent a car from Houston George Bush Intcntl for about $34 per day.

  • What are points of interest worth seeing during a layover in Panama City?

    Most Panama City visitors opt to spend their time at Panama Old Cathedral, Amador Causeway, and Panama Canal. Panama Old Cathedral, Amador Causeway, and Panama Canal can be accessed by traveling approximately 13.2 mi, 14.7 mi, and 15.1 mi, respectively from Panama City Tocumen Intl. Travelers can book a car rental at Panama City Tocumen Intl for about $12 per day to make their sightseeing more efficient.

  • Where are the least popular layover locations for San Francisco to Santiago flights?

    The least popular layover on flights from San Francisco to Santiago is Dallas. Atlanta is the second least popular location for layovers on flights from San Francisco to Santiago.

  • Can I find deals for flights from San Francisco to Santiago that include hotel bookings?

    Yes. In addition to deals on San Francisco to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santiago.

  • Can I find deals for business class flights from San Francisco to Santiago?

    Yes. Cheapflights offers flight deals from San Francisco to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Santiago?

    Currently, April is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $752). Flying from San Francisco to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for San Francisco to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from San Francisco to Santiago

Discover the top 7 airlines that operate flights from San Francisco to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$492Average$662FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$501Average$723FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$593Average$848FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$658Average$919FlexibilityNo cancel feeOn-time71%
DeltaCheapest$658Average$833FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$662Average$880FlexibilityNo cancel feeOn-time81%
AeromexicoCheapest$758Average$998FlexibilityNo cancel feeOn-timeN/A

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