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$233+ Cheap flights from San Francisco (SFO) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/25. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — SCL
Aug 23 — Aug 301
Sat 8/23
Sat 8/30
1 adult, Economy
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Cheapflights Tip: The best prices from San Francisco to Santiago Arturo Merino Benitez are usually found in August or May, booked 20 days in advance, depart on a Wednesday or Monday and return on a Saturday

Cheap flight deals from San Francisco to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 18, 2025.

Round-trip from

$477
(Cheapflightsfares)

One-way from

$233
(Cheapflightsfares)

Popular in

December

Cheapest in

August

Average price

$707
From San Francisco to Santiago Arturo Merino Benitez
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One-way flight from San Francisco to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 13% potential increase in price ($127 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($41 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from San Francisco to Santiago

Cheapest flights from San Francisco to Santiago
Explore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/72:20 pmSFO - SCL
2 stops20h 05mAvianca
Mon 9/297:10 amSCL - SFO
2 stops19h 35mAvianca
Deal found 8/17$477
This Cheapflightsfares deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/212:30 amSFO - SCL
2 stops22h 45mAvianca
Wed 8/272:30 pmSCL - SFO
2 stops36h 25mAvianca
Deal found 8/17$487
This Priceline deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/232:30 amSFO - SCL
2 stops17h 00mAvianca
Thu 8/286:10 amSCL - SFO
2 stops19h 35mAvianca
Deal found 8/16$492
This Cheapflightsfares deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/192:20 pmSFO - SCL
2 stops29h 10mAvianca
Tue 8/262:30 pmSCL - SFO
2 stops25h 05mAvianca
Deal found 8/18$493
This Cheapflightsfares deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/82:20 pmSFO - SCL
2 stops34h 55mAvianca
Fri 10/33:30 pmSCL - SFO
2 stops36h 25mAvianca
Deal found 8/18$503
This Gotogate deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/62:20 pmSFO - SCL
2 stops29h 10mAvianca
Mon 10/2012:55 amSCL - SFO
2 stops27h 00mAvianca
Deal found 8/17$504
This Priceline deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/152:20 pmSFO - SCL
2 stops29h 10mAvianca
Fri 11/141:35 amSCL - SFO
2 stops26h 45mAvianca
Deal found 8/17$509
This Priceline deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/302:30 amSFO - SCL
2 stops22h 45mAvianca
Mon 9/2912:55 amSCL - SFO
2 stops25h 50mAvianca
Deal found 8/18$527
This Priceline deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/142:20 pmSFO - SCL
2 stops34h 55mAvianca
Sun 9/213:30 pmSCL - SFO
2 stops25h 05mAvianca
Deal found 8/17$544
This Orbitz deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2812:05 amSFO - SCL
2 stops34h 20mAvianca
Sun 10/512:55 amSCL - SFO
2 stops25h 50mAvianca
Deal found 8/17$562
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:00 amSFO - SCL
1 stop20h 50mAmerican Airlines
Wed 12/1711:15 pmSCL - SFO
1 stop17h 41mAmerican Airlines
Deal found 8/18$564

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.

Fly from

San Francisco

Fly to

Santiago

Route

Depart

Return

Price

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 9/15

2:20 pm-2:25 pm

2 stops20h 05m

Santiago Arturo Merino Benitez

Tue 9/23

3:30 pm-12:35 pm

2 stops25h 05m

$477

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 9/29

2:20 pm-5:15 am

2 stops34h 55m

Santiago Arturo Merino Benitez

Mon 10/6

7:10 am-10:45 pm

2 stops19h 35m

$493

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 2/10

7:50 am-8:50 am

1 stop20h 00m

Santiago Arturo Merino Benitez

Tue 2/24

10:45 pm-6:55 pm

1 stop25h 10m

$514

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 2/9

7:50 am-8:50 am

1 stop20h 00m

Santiago Arturo Merino Benitez

Mon 2/23

10:45 pm-2:50 pm

1 stop21h 05m

$514

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 2/10

5:00 am-8:50 am

1 stop22h 50m

Santiago Arturo Merino Benitez

Wed 2/18

10:45 pm-9:43 am

1 stop15h 58m

$514

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 2/10

7:50 am-8:50 am

1 stop20h 00m

Santiago Arturo Merino Benitez

Mon 2/23

10:45 pm-6:55 pm

1 stop25h 10m

$514

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 2/9

8:31 am-8:50 am

1 stop19h 19m

Santiago Arturo Merino Benitez

Wed 2/18

10:45 pm-9:43 am

1 stop15h 58m

$514

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 2/9

7:50 am-8:50 am

1 stop20h 00m

Santiago Arturo Merino Benitez

Thu 2/19

10:45 pm-2:50 pm

1 stop21h 05m

$514

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 2/9

8:31 am-8:50 am

1 stop19h 19m

Santiago Arturo Merino Benitez

Tue 2/24

10:45 pm-5:05 pm

1 stop23h 20m

$514

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 2/10

7:50 am-8:50 am

1 stop20h 00m

Santiago Arturo Merino Benitez

Thu 2/19

10:45 pm-5:05 pm

1 stop23h 20m

$514

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/17

Showing 1-10 of 18 results
1
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Best time to book a flight from San Francisco to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santiago

What is the cheapest month to book a flight from San Francisco to Santiago?

Currently, April is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $752). Flying from San Francisco to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to SCL?

Find hourly flight availability from San Francisco to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 18, 2025.

One of the essential ways to save on airfare from San Francisco to Santiago is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 18% on airfare.

What is the cheapest day to fly from San Francisco to Santiago?

Use this chart to determine the cheapest time to fly round-trip from San Francisco to Santiago. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their San Francisco to Santiago flight should consider departing on Tuesday evenings when fares are most often at their lowest. Saturday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

What’s the top layover airport for flights from San Francisco to Santiago?

Share of 1-stop round-trip flights from San Francisco to Santiago chosen by Cheapflights users in the past 12 months, using the same layover each way.

Los Angeles (LAX) – chosen by Cheapflights users on 33% of 1-stop itineraries from San Francisco to Santiago on Cheapflights.

What’s the cheapest layover airport for flights from San Francisco to Santiago?

Average round-trip fare for 1-stop flights from San Francisco to Santiago, chosen by Cheapflights users in the past 12 months, with the same layover each way.

Panama City (PTY) is the most affordable 1-stop option, with an average round-trip price of $735.

What’s the fastest layover option from San Francisco to Santiago?

Shortest average travel time for 1-stop one-way flights from San Francisco to Santiago, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.

Flights via Los Angeles (LAX) have the shortest average one-way travel time for 1-stop routes: 15h 24m.

Which airport typically offers the quickest layover for flights from San Francisco to Santiago?

Average layover duration for 1-stop one-way flights from San Francisco to Santiago, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.

Flights via Atlanta (ATL) offer the fastest connection on this route, with an average layover time of 2h 11m.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated August 18, 2025.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and Copa Airlines from San Francisco to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,844 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.5
Good
1,510 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,925 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Francisco to Santiago?

    A quick flight from San Francisco to Santiago can take about 20h. Avianca provides one of the quickest options available for as low as $514. There are 5918 mi between San Francisco and Santiago. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from San Francisco to Santiago round-trip?

    Currently priced at $534, Copa Airlines will fly you from San Francisco to Santiago and back. In addition to Copa Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Avianca and United Airlines - these airlines can fly you to your destination from $591 and $622, respectively. Copa Airlines is currently priced 35% below the average price you’ll pay for this route.

  • Where are the most common layover locations when flying from San Francisco to Santiago?

    Of the flights from San Francisco to Santiago that have layovers, most of them stop in Los Angeles. San Francisco to Santiago flights stop in Houston the next most. Panama City comes next as the third most popular layover location for San Francisco to Santiago flights.

  • What are some popular things to do or see while on a layover in Los Angeles?

    Hollywood Bowl, Hollywood Walk of Fame, and The Wiltern are currently the most popular points of interest in Los Angeles at the moment. Hollywood Bowl, Hollywood Walk of Fame and The Wiltern are located about 12.5 mi, 11.7 mi, and 10.0 mi, respectively from Los Angeles if you are interested in checking them out. Travelers in need of a car in Los Angeles can rent one for about $52 per day.

  • What are some popular points of interest to see during a layover in Houston?

    The majority of Houston visitors spend their time at Space Center Houston, House of Blues Houston, and Revention Music Center. Those on a layover in Houston interested in visiting Space Center Houston, House of Blues Houston, or Revention Music Center can do so by traveling 33.5 mi, 16.1 mi, and 15.5 mi, respectively from Houston George Bush Intcntl. Those looking to explore during their layover in Houston can rent a car from Houston George Bush Intcntl for about $40 per day.

  • What are points of interest worth seeing during a layover in Panama City?

    Most Panama City visitors opt to spend their time at Panama Old Cathedral, Amador Causeway, and Panama Canal. Panama Old Cathedral, Amador Causeway, and Panama Canal can be accessed by traveling approximately 13.2 mi, 14.7 mi, and 15.1 mi, respectively from Panama City Tocumen Intl. Travelers can book a car rental at Panama City Tocumen Intl for about $14 per day to make their sightseeing more efficient.

  • Where are the least popular layover locations for San Francisco to Santiago flights?

    The least popular layover on flights from San Francisco to Santiago is Dallas. Atlanta is the second least popular location for layovers on flights from San Francisco to Santiago.

  • Can I find deals for flights from San Francisco to Santiago that include hotel bookings?

    Yes. In addition to deals on San Francisco to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santiago.

  • Can I find deals for business class flights from San Francisco to Santiago?

    Yes. Cheapflights offers flight deals from San Francisco to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Santiago?

    Currently, April is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $752). Flying from San Francisco to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for San Francisco to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from San Francisco to Santiago

Discover the top 7 airlines that operate flights from San Francisco to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$534Average$705FlexibilityNo cancel feeOn-time70%
AviancaCheapest$591Average$665FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$622Average$848FlexibilityNo cancel feeOn-time69%
DeltaCheapest$642Average$825FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$657Average$911FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$659Average$884FlexibilityNo cancel feeOn-time81%
AeromexicoCheapest$758Average$1,005FlexibilityNo cancel feeOn-timeN/A

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