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$323+ Cheap flights from San Francisco (SFO) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/21. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — SCL
Apr 23 — Apr 301
Thu 4/23
Thu 4/30
1 adult, Economy
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Cheap flight deals from San Francisco to Santiago

Cheapest flights from San Francisco to Santiago
Explore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 24, 2026.

This Mytrip deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/132:15 pm
SFO
-
SCL
2 stops20h 15m
Multiple Airlines
Wed 5/2712:30 am
SCL
-
SFO
2 stops26h 25m
Multiple Airlines
Deal found 3/23$648
This Mytrip deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/711:55 pm
SFO
-
SCL
2 stops21h 16m
Multiple Airlines
Thu 5/146:40 am
SCL
-
SFO
2 stops18h 55m
Multiple Airlines
Deal found 3/23$684
This Mytrip deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2011:55 pm
SFO
-
SCL
3 stops25h 01m
Multiple Airlines
Mon 4/276:40 am
SCL
-
SFO
2 stops33h 10m
Multiple Airlines
Deal found 3/21$696
This Mytrip deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/52:30 am
SFO
-
SCL
3 stops22h 46m
Multiple Airlines
Tue 5/1212:30 am
SCL
-
SFO
2 stops25h 05m
Multiple Airlines
Deal found 3/20$697
This Mytrip deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/162:15 pm
SFO
-
SCL
3 stops30h 56m
Multiple Airlines
Mon 4/206:40 am
SCL
-
SFO
2 stops33h 10m
Multiple Airlines
Deal found 3/23$705
This Mytrip deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1111:55 pm
SFO
-
SCL
3 stops25h 01m
Multiple Airlines
Sun 5/246:40 am
SCL
-
SFO
2 stops18h 55m
Multiple Airlines
Deal found 3/22$712
This Mytrip deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1211:55 pm
SFO
-
SCL
3 stops25h 01m
Multiple Airlines
Sun 4/193:20 pm
SCL
-
SFO
2 stops24h 30m
Multiple Airlines
Deal found 3/23$718

Find flight deals from San Francisco to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$648
(Mytrip)

One-way from

$323
(Kiwi.com)

Popular in

December

Cheapest in

January

Average price

$806
Provider with most accurate pricing for San Francisco-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Francisco-Santiago Arturo Merino Benitez flights.
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From San Francisco to Santiago Arturo Merino Benitez
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One-way flight from San Francisco to Santiago Arturo Merino Benitez
Search Deals
High demand for flights, 2% potential price rise
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 6/28

7:00 am-5:35 am

1 stop19h 35m

Santiago Arturo Merino Benitez

Sun 7/12

11:25 pm-6:59 pm

1 stop22h 34m

$785

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sat 6/27

9:20 am-5:35 am

1 stop17h 15m

Santiago Arturo Merino Benitez

Tue 7/21

10:55 pm-8:05 pm

1 stop24h 10m

$785

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 7/1

6:55 pm-7:45 pm

2 stops21h 50m

Santiago Arturo Merino Benitez

Tue 7/14

11:00 pm-5:37 pm

2 stops21h 37m

$790

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Fri 6/26

8:45 am-6:50 am

1 stop19h 05m

Santiago Arturo Merino Benitez

Mon 7/13

11:00 pm-10:49 pm

2 stops26h 49m

$790

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 7/12

8:55 am-5:35 am

1 stop17h 40m

Santiago Arturo Merino Benitez

Sun 8/2

11:25 pm-3:11 pm

1 stop18h 46m

$835

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Fri 7/17

11:05 am-5:35 am

1 stop15h 30m

Santiago Arturo Merino Benitez

Sun 8/2

11:25 pm-5:50 pm

1 stop21h 25m

$835

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 7/1

1:00 pm-7:45 pm

2 stops27h 45m

Santiago Arturo Merino Benitez

Fri 7/10

11:25 pm-8:19 pm

1 stop23h 54m

$840

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 6/30

8:45 am-6:50 am

1 stop19h 05m

Santiago Arturo Merino Benitez

Tue 7/14

12:40 am-5:37 pm

2 stops19h 57m

$882

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Thu 6/11

10:30 pm-6:00 am

2 stops28h 30m

Santiago Arturo Merino Benitez

Tue 6/23

11:25 pm-11:59 am

1 stop15h 34m

$905
Quickest round-trip

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Fri 7/17

11:05 am-5:35 am

1 stop15h 30m

Santiago Arturo Merino Benitez

Fri 7/31

11:25 pm-11:59 am

1 stop15h 34m

$935

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/21

Showing 1-10 of 24 resultsSorted by cheapest first
1
2
3

Compare providers for flights from San Francisco to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Santiago in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*2 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
OvagoPrice Accuracy2 starsTrust Score*3 stars
SmartFaresPrice Accuracy1 starTrust Score*1 star
JustAirTicketPrice Accuracy-Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on San Francisco-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Francisco-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Francisco to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santiago

How far ahead should I book a flight from San Francisco to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Santiago. Price data was last updated on March 13, 2026.

Booking 23 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Francisco to Santiago?

Currently, March is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $401). Flying from San Francisco to Santiago in July is currently the most expensive (average of $663). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated March 24, 2026.
Peruse reviews from past customers who have flown with Delta,Copa Airlines, andLATAM Airlines from San Francisco to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,321 reviews

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
7.9
Good
8,321 reviews
Delta
7.9
Good
8,321 reviews

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.5
Good
1,577 reviews
Delta
7.9
Good
8,321 reviews

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.4
Good
1,910 reviews
Delta
7.9
Good
8,321 reviews

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
9,469 reviews
Delta
7.9
Good
8,321 reviews

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.1
Good
11,491 reviews
Delta
7.9
Good
8,321 reviews

Boarding

8.1

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Francisco to Santiago?

    A quick flight from San Francisco to Santiago can take about 19h 35m. Delta provides one of the quickest options available for as low as $785. There are 5918 mi between San Francisco and Santiago.

  • What are the cheapest airlines flying from San Francisco to Santiago round-trip?

    Currently priced at $366, Avianca will fly you from San Francisco to Santiago and back. In addition to Avianca, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and United Airlines - these airlines can fly you to your destination from $494 and $494, respectively. Avianca is currently priced 53% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from San Francisco to Santiago one-way?

    $191 is the cheapest one-way deal found within the past few days, from Avianca. You may also be able to find cheap deals on United Airlines and Copa Airlines, with prices starting from $248 and $299, respectively.

  • Where are the most common layover locations when flying from San Francisco to Santiago?

    Of the flights from San Francisco to Santiago that have layovers, most of them stop in Houston. San Francisco to Santiago flights stop in Los Angeles the next most.

  • What are some popular things to do or see while on a layover in Houston?

    Space Center Houston, House of Blues Houston, and Revention Music Center are currently the most popular points of interest in Houston at the moment. Space Center Houston, House of Blues Houston and Revention Music Center are located about 33.5 mi, 16.1 mi, and 15.5 mi, respectively from Houston George Bush Intcntl if you are interested in checking them out. Travelers in need of a car in Houston can rent one for about $40 per day.

  • What are some popular points of interest to see during a layover in Los Angeles?

    The majority of Los Angeles visitors spend their time at Hollywood Bowl, Hollywood Walk of Fame, and L.A. Live. Those on a layover in Los Angeles interested in visiting Hollywood Bowl, Hollywood Walk of Fame, or L.A. Live can do so by traveling 12.4 mi, 11.7 mi, and 10.9 mi, respectively from Los Angeles. Those looking to explore during their layover in Los Angeles can rent a car from Los Angeles for about $43 per day.

  • Where are the least popular layover locations for San Francisco to Santiago flights?

    The least popular layover on flights from San Francisco to Santiago is Panama City. Atlanta is the second least popular location for layovers on flights from San Francisco to Santiago.

  • Can I find deals for flights from San Francisco to Santiago that include hotel bookings?

    Yes. In addition to deals on San Francisco to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santiago.

  • Can I find deals for business class flights from San Francisco to Santiago?

    Yes. Cheapflights offers flight deals from San Francisco to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Santiago?

    Currently, March is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $401). Flying from San Francisco to Santiago in July is currently the most expensive (average of $663). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 7 airlines flying from San Francisco to Santiago

Discover the top 7 airlines that operate flights from San Francisco to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$366Average$642FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$494Average$733FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$494Average$881FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$501Average$703FlexibilityNo cancel feeOn-time70%
DeltaCheapest$593Average$833FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$593Average$830FlexibilityNo cancel feeOn-time81%
AeromexicoCheapest$758Average$1,100FlexibilityNo cancel feeOn-timeN/A

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