What are the cheapest airlines flying from San Francisco to Santiago round-trip?

Currently priced at $598, Avianca will fly you from San Francisco to Santiago and back. In addition to Avianca, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from LATAM Airlines and Copa Airlines - these airlines can fly you to your destination from $640 and $644, respectively. Avianca is currently priced 28% below the average price you’ll pay for this route.

What are the cheapest airlines to fly from San Francisco to Santiago one-way?

$303 is the cheapest one-way deal found within the past few days, from Avianca. You may also be able to find cheap deals on Copa Airlines and LATAM Airlines, with prices starting from $320 and $367, respectively.

What are the most popular airlines that fly from San Francisco to Santiago?

American Airlines, Aeromexico and Avianca are the most popular airlines when flying from San Francisco to Santiago.

Where are the most common layover locations when flying from San Francisco to Santiago?

Of the flights from San Francisco to Santiago that have layovers, most of them stop in Los Angeles. San Francisco to Santiago flights stop in Panama City the next most. Houston comes next as the third most popular layover location for San Francisco to Santiago flights.

Where are the least popular layover locations for San Francisco to Santiago flights?

The least popular layover on flights from San Francisco to Santiago is Dallas. Atlanta is the second least popular location for layovers on flights from San Francisco to Santiago.

What are some popular things to do or see while on a layover in Los Angeles?

Hollywood Bowl, Hollywood Walk of Fame, and L.A. Live are currently the most popular points of interest in Los Angeles at the moment. Hollywood Bowl, Hollywood Walk of Fame and L.A. Live are located about 12.5 mi, 11.7 mi, and 10.8 mi, respectively from Los Angeles if you are interested in checking them out. Travelers in need of a car in Los Angeles can rent one for about $40 per day.

What are some popular points of interest to see during a layover in Panama City?

The majority of Panama City visitors spend their time at Panama Old Cathedral, Amador Causeway, and Panama Canal. Those on a layover in Panama City interested in visiting Panama Old Cathedral, Amador Causeway, or Panama Canal can do so by traveling 13.2 mi, 14.7 mi, and 15.1 mi, respectively from Panama City Tocumen Intl. Those looking to explore during their layover in Panama City can rent a car from Panama City Tocumen Intl for about $11 per day.

What are points of interest worth seeing during a layover in Houston?

Most Houston visitors opt to spend their time at Space Center Houston, House of Blues Houston, and Revention Music Center. Space Center Houston, House of Blues Houston, and Revention Music Center can be accessed by traveling approximately 33.5 mi, 16.1 mi, and 15.5 mi, respectively from Houston George Bush Intcntl. Travelers can book a car rental at Houston George Bush Intcntl for about $41 per day to make their sightseeing more efficient.

What is the cheapest day to fly round-trip from San Francisco to Santiago?

Flying to your destination on a Friday can be more expensive, but this shouldn’t discourage you from finding affordable options to get to Santiago. Check prices with Cheapflights to find a great deal for your trip.

How far in advance should I book a flight from San Francisco to Santiago?

To save up to 10% on this flight, we recommend booking at least 21 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from San Francisco to Santiago from $651 1-2 weeks out and tickets from $779 for flights departing within the next 72 hours.

What is the cheapest month to fly from San Francisco to Santiago?

August can be a great time to fly to Santiago from San Francisco with a flight ticket averaging about $836. Cheapflights users have found deals in the month of August for as cheap as $520. The most expensive prices can be found in the month of December.

Can I find deals for flights from San Francisco to Santiago that include hotel bookings?

Yes. In addition to deals on San Francisco to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from San Francisco to Santiago?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santiago.

Can I find deals for business class flights from San Francisco to Santiago?

Yes. Cheapflights offers flight deals from San Francisco to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$303+ Flights from San Francisco to Santiago

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Cheapflights Tip: The best prices from San Francisco to Santiago Arturo Merino Benitez are usually found in August or May, booked 20 days in advance, depart on a Wednesday or Monday and return on a Saturday

Cheap flight deals from San Francisco to Santiago

Round-trip from	$598 (Priceline)
One-way from	$303 (Cheapflightsfares)
Popular in	December
Cheapest in	August
Average price	$835

From San Francisco to Santiago Arturo Merino Benitez

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One-way flight from San Francisco to Santiago Arturo Merino Benitez

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Highest demand for flights based on searches. 14% potential increase in price ($138 potential increase over avg. RT price).

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Cheapest flight prices on average. 5% potential price decrease ($44 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Find flight deals from San Francisco to Santiago

Cheapest flights from San Francisco to Santiago
Explore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Mon 8/42:20 pmSFO - SCL

2 stops20h 05mAvianca

Wed 8/132:30 pmSCL - SFO

2 stops25h 05mAvianca

Deal found 6/10

$598

Tue 8/121:28 amSFO - SCL

1 stop18h 40mMultiple Airlines

Fri 8/222:30 pmSCL - SFO

2 stops25h 05mMultiple Airlines

Deal found 6/10

$639

Mon 8/181:28 amSFO - SCL

1 stop18h 40mCopa Airlines

Tue 8/264:10 amSCL - SFO

1 stop22h 30mCopa Airlines

Deal found 6/11

$644

Thu 8/2112:30 pmSFO - SCL

1 stop14h 30mLATAM Airlines

Thu 8/2810:45 pmSCL - SFO

1 stop14h 15mLATAM Airlines

Deal found 6/12

$651

Thu 8/287:00 amSFO - SCL

2 stops20h 50mDelta

Mon 9/155:55 pmSCL - SFO

2 stops22h 05mDelta

Deal found 6/11

$688

Tue 11/412:43 amSFO - SCL

1 stop27h 07mUnited Airlines

Wed 1/2110:45 pmSCL - SFO

1 stop23h 20mUnited Airlines

Deal found 6/12

$695

Fri 10/3112:47 amSFO - SCL

1 stop27h 03mAmerican Airlines

Thu 11/1310:15 pmSCL - SFO

1 stop18h 36mAmerican Airlines

Deal found 6/12

$791

Best flights from San Francisco to Santiago
Discover carefully curated flight deals from San Francisco to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2025.

Mon 8/42:20 pmSFO - SCL

2 stops20h 05mAvianca

Wed 8/132:30 pmSCL - SFO

2 stops25h 05mAvianca

Deal found 6/10

$598

Tue 8/121:28 amSFO - SCL

1 stop18h 40mMultiple Airlines

Fri 8/222:30 pmSCL - SFO

2 stops25h 05mMultiple Airlines

Deal found 6/10

$639

Mon 9/157:30 amSFO - SCL

2 stops19h 00mLATAM Airlines

Mon 10/208:15 amSCL - SFO

1 stop18h 58mLATAM Airlines

Deal found 6/12

$640

Mon 8/181:28 amSFO - SCL

1 stop18h 40mCopa Airlines

Tue 8/264:10 amSCL - SFO

1 stop22h 30mCopa Airlines

Deal found 6/11

$644

Thu 8/287:00 amSFO - SCL

2 stops20h 50mDelta

Mon 9/155:55 pmSCL - SFO

2 stops22h 05mDelta

Deal found 6/11

$688

Tue 11/412:43 amSFO - SCL

1 stop27h 07mUnited Airlines

Wed 1/2110:45 pmSCL - SFO

1 stop21h 05mUnited Airlines

Deal found 6/11

$695

Fri 10/3112:47 amSFO - SCL

1 stop27h 03mAmerican Airlines

Thu 11/1310:15 pmSCL - SFO

1 stop18h 36mAmerican Airlines

Deal found 6/12

$791

Last-minute flights from San Francisco to Santiago
Discover last-minute flight deals from San Francisco to Santiago. Data last updated June 12, 2025 and is based on user searches.

Tue 6/172:20 pmSFO - SCL

2 stops31h 30mAvianca

Mon 7/142:30 pmSCL - SFO

2 stops36h 25mAvianca

Deal found 6/10

$811

Tue 6/177:00 amSFO - SCL

1 stop20h 45mDelta

Mon 7/1410:45 pmSCL - SFO

1 stop23h 53mDelta

Deal found 6/10

$864

Tue 6/171:37 amSFO - SCL

1 stop22h 10mMultiple Airlines

Tue 6/2411:00 amSCL - SFO

2 stops26h 15mMultiple Airlines

Deal found 6/11

$1,015

Tue 6/1710:55 amSFO - SCL

1 stop15h 09mCopa Airlines

Sun 7/132:23 amSCL - SFO

1 stop24h 17mCopa Airlines

Deal found 6/12

$1,346

Tue 6/1710:00 pmSFO - SCL

1 stop33h 05mQantas Airways

Tue 7/812:40 amSCL - SFO

2 stops44h 05mQantas Airways

Deal found 6/12

$32,520

Wed 6/1810:55 amSFO - SCL

1 stop16h 05mLATAM Airlines

Wed 6/258:40 pmSCL - SFO

1 stop16h 35mLATAM Airlines

Deal found 6/9

$783

Thu 6/197:00 amSFO - SCL

2 stops21h 00mAmerican Airlines

Thu 6/269:55 pmSCL - SFO

2 stops20h 19mAmerican Airlines

Deal found 6/12

$973

Sat 6/287:00 amSFO - SCL

2 stops21h 00mAmerican Airlines

Wed 7/29:55 pmSCL - SFO

2 stops21h 02mAmerican Airlines

Deal found 6/12

$928

Wed 7/91:25 amSFO - SCL

1 stop14h 59mCopa Airlines

Thu 7/175:22 amSCL - SFO

1 stop21h 18mCopa Airlines

Deal found 6/12

$672

Thu 7/1012:05 amSFO - SCL

2 stops19h 25mAvianca

Tue 7/226:10 amSCL - SFO

2 stops20h 45mAvianca

Deal found 6/11

$648

Thu 7/1012:30 pmSFO - SCL

1 stop14h 30mLATAM Airlines

Mon 7/2110:45 pmSCL - SFO

1 stop15h 47mLATAM Airlines

Deal found 6/11

$757

Sun 7/131:25 amSFO - SCL

1 stop18h 43mMultiple Airlines

Tue 7/296:10 amSCL - SFO

2 stops20h 45mMultiple Airlines

Deal found 6/10

$703

One-way flights from San Francisco to Santiago
Search for one-way flight options from San Francisco to Santiago. Find affordable one-way fares based on user searches. Data last updated June 12, 2025.

Wed 8/612:05 amSFO - SCL

2 stops19h 25mAvianca

Deal found 6/12

$303

Sun 9/141:28 amSFO - SCL

1 stop18h 36mCopa Airlines

Deal found 6/10

$320

Thu 8/712:30 pmSFO - SCL

1 stop14h 30mLATAM Airlines

Deal found 6/12

$367

Mon 9/152:45 pmSFO - SCL

3 stops35h 15mMultiple Airlines

Deal found 6/10

$391

Mon 12/18:50 amSFO - SCL

1 stop22h 20mAir Canada

Deal found 6/11

$416

Sat 7/512:13 pmSFO - SCL

1 stop15h 52mAmerican Airlines

Deal found 6/11

$417

Tue 7/157:05 amSFO - SCL

1 stop20h 40mDelta

Deal found 6/12

$418

Sun 11/3012:43 amSFO - SCL

1 stop27h 07mUnited Airlines

Deal found 6/10

$436

Mon 7/146:45 pmSFO - SCL

3 stops55h 19mTurkish Airlines

Deal found 6/12

$2,417

Wed 10/227:20 pmSFO - SCL

1 stop33h 15mBritish Airways

Deal found 6/11

$15,545

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 8/4

2:20 pm-1:25 pm

2 stops20h 05m

Santiago Arturo Merino Benitez

Wed 8/13

2:30 pm-12:35 pm

2 stops25h 05m

$598

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 8/12

1:28 am-11:08 pm

1 stop18h 40m

Santiago Arturo Merino Benitez

Fri 8/22

2:30 pm-12:35 pm

2 stops25h 05m

$639

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 8/18

1:28 am-11:08 pm

1 stop18h 40m

Santiago Arturo Merino Benitez

Tue 8/26

4:10 am-11:40 pm

1 stop22h 30m

$644

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Thu 8/21

10:55 am-6:00 am

1 stop16h 05m

Santiago Arturo Merino Benitez

Mon 8/25

10:45 pm-10:00 am

1 stop14h 15m

$651

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Thu 8/28

7:00 am-6:50 am

2 stops20h 50m

Santiago Arturo Merino Benitez

Mon 9/15

5:55 pm-12:00 pm

2 stops22h 05m

$688

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 11/4

12:43 am-8:50 am

1 stop27h 07m

Santiago Arturo Merino Benitez

Wed 1/21

10:45 pm-5:05 pm

1 stop23h 20m

$695

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Fri 10/31

12:47 am-7:50 am

1 stop27h 03m

Santiago Arturo Merino Benitez

Thu 11/13

10:15 pm-11:51 am

1 stop18h 36m

$791

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 8/6

12:05 am-10:30 pm

2 stops19h 25m

$303

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 8/6

1:28 am-2:47 am

1 stop22h 19m

$320

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Thu 8/7

12:30 pm-6:00 am

1 stop14h 30m

$367

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/12

Showing 1-10 of 17 results

Best time to book a flight from San Francisco to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from San Francisco with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santiago

How far ahead should I book a flight from San Francisco to Santiago?

Booking 20 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Francisco to Santiago?

Currently, April is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $752). Flying from San Francisco to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to SCL?

One of the essential ways to save on airfare from San Francisco to Santiago is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 18% on airfare.

What is the cheapest day to fly from San Francisco to Santiago?

Travelers seeking maximum savings on their San Francisco to Santiago flight should consider departing on Tuesday evenings when fares are most often at their lowest. Saturday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in Santiago by month

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

Temperature in Santiago by month

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

Reviews of airlines servicing Santiago

To help decide which airline to fly from San Francisco to Santiago, see what other customers have to say about Delta, LATAM Airlines and Copa Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta

8.0

Very good

7,946 reviews

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

LATAM Airlines

7.5

Good

1,785 reviews

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Copa Airlines

7.5

Good

1,451 reviews

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines

7.4

Good

8,790 reviews

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Turkish Airlines

7.3

Good

3,848 reviews

Delta

8.0

Very good

7,946 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

What are the cheapest airlines flying from San Francisco to Santiago round-trip?
Currently priced at $598, Avianca will fly you from San Francisco to Santiago and back. In addition to Avianca, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from LATAM Airlines and Copa Airlines - these airlines can fly you to your destination from $640 and $644, respectively. Avianca is currently priced 28% below the average price you’ll pay for this route.
What are the cheapest airlines to fly from San Francisco to Santiago one-way?
$303 is the cheapest one-way deal found within the past few days, from Avianca. You may also be able to find cheap deals on Copa Airlines and LATAM Airlines, with prices starting from $320 and $367, respectively.
Where are the most common layover locations when flying from San Francisco to Santiago?
Of the flights from San Francisco to Santiago that have layovers, most of them stop in Los Angeles. San Francisco to Santiago flights stop in Panama City the next most. Houston comes next as the third most popular layover location for San Francisco to Santiago flights.
What are some popular things to do or see while on a layover in Los Angeles?
Hollywood Bowl, Hollywood Walk of Fame, and L.A. Live are currently the most popular points of interest in Los Angeles at the moment. Hollywood Bowl, Hollywood Walk of Fame and L.A. Live are located about 12.5 mi, 11.7 mi, and 10.8 mi, respectively from Los Angeles if you are interested in checking them out. Travelers in need of a car in Los Angeles can rent one for about $40 per day.
What are some popular points of interest to see during a layover in Panama City?
The majority of Panama City visitors spend their time at Panama Old Cathedral, Amador Causeway, and Panama Canal. Those on a layover in Panama City interested in visiting Panama Old Cathedral, Amador Causeway, or Panama Canal can do so by traveling 13.2 mi, 14.7 mi, and 15.1 mi, respectively from Panama City Tocumen Intl. Those looking to explore during their layover in Panama City can rent a car from Panama City Tocumen Intl for about $11 per day.
What are points of interest worth seeing during a layover in Houston?
Most Houston visitors opt to spend their time at Space Center Houston, House of Blues Houston, and Revention Music Center. Space Center Houston, House of Blues Houston, and Revention Music Center can be accessed by traveling approximately 33.5 mi, 16.1 mi, and 15.5 mi, respectively from Houston George Bush Intcntl. Travelers can book a car rental at Houston George Bush Intcntl for about $41 per day to make their sightseeing more efficient.
Where are the least popular layover locations for San Francisco to Santiago flights?
The least popular layover on flights from San Francisco to Santiago is Dallas. Atlanta is the second least popular location for layovers on flights from San Francisco to Santiago.
Can I find deals for flights from San Francisco to Santiago that include hotel bookings?
Yes. In addition to deals on San Francisco to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from San Francisco to Santiago?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santiago.
Can I find deals for business class flights from San Francisco to Santiago?
Yes. Cheapflights offers flight deals from San Francisco to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from San Francisco to Santiago?
Currently, April is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $752). Flying from San Francisco to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Other flights to Santiago

Top 7 airlines flying from San Francisco to Santiago

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$478	Average$642	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$534	Average$747	FlexibilityNo cancel fee	On-time70%
United Airlines	Cheapest$622	Average$848	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$642	Average$828	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$657	Average$923	FlexibilityNo cancel fee	On-time71%
LATAM Airlines	Cheapest$659	Average$898	FlexibilityNo cancel fee	On-time81%
Aeromexico	Cheapest$758	Average$998	FlexibilityNo cancel fee	On-timeN/A

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$303+ Cheap flights from San Francisco (SFO) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/6. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from San Francisco to Santiago with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from San Francisco to Santiago Arturo Merino Benitez are usually found in August or May, booked 20 days in advance, depart on a Wednesday or Monday and return on a Saturday

Cheap flight deals from San Francisco to Santiago

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from San Francisco to Santiago

Cheapest flights from San Francisco to SantiagoExplore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Explore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.

Best time to book a flight from San Francisco to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from San Francisco with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santiago

How far ahead should I book a flight from San Francisco to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Santiago. Price data was last updated on June 9, 2025.

What is the cheapest month to book a flight from San Francisco to Santiago?

What is the cheapest time of day to fly from SFO to SCL?

Find hourly flight availability from San Francisco to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

What is the cheapest day to fly from San Francisco to Santiago?

Use this chart to determine the cheapest time to fly round-trip from San Francisco to Santiago. Price data was last updated on December 16, 2024.

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

Reviews of airlines servicing Santiago

To help decide which airline to fly from San Francisco to Santiago, see what other customers have to say about Delta, LATAM Airlines and Copa Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from San Francisco to Santiago round-trip?

What are the cheapest airlines to fly from San Francisco to Santiago one-way?

Where are the most common layover locations when flying from San Francisco to Santiago?

What are some popular things to do or see while on a layover in Los Angeles?

What are some popular points of interest to see during a layover in Panama City?

What are points of interest worth seeing during a layover in Houston?

Where are the least popular layover locations for San Francisco to Santiago flights?

Can I find deals for flights from San Francisco to Santiago that include hotel bookings?

How can I find direct flights from San Francisco to Santiago?

Can I find deals for business class flights from San Francisco to Santiago?

What is the cheapest month to book a flight from San Francisco to Santiago?

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Cheapest flights from San Francisco to Santiago
Explore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.