What are the cheapest airlines flying from San Francisco to Santiago round-trip?

Currently priced at $652, Copa Airlines will fly you from San Francisco to Santiago and back. In addition to Copa Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from LATAM Airlines and Avianca - these airlines can fly you to your destination from $664 and $665, respectively. Copa Airlines is currently priced 24% below the average price you’ll pay for this route.

What are the cheapest airlines to fly from San Francisco to Santiago one-way?

$310 is the cheapest one-way deal found within the past few days, from Copa Airlines. You may also be able to find cheap deals on Avianca and American Airlines, with prices starting from $313 and $405, respectively.

What are the most popular airlines that fly from San Francisco to Santiago?

American Airlines, Aeromexico and Avianca are the most popular airlines when flying from San Francisco to Santiago.

Where are the most common layover locations when flying from San Francisco to Santiago?

Of the flights from San Francisco to Santiago that have layovers, most of them stop in Los Angeles. San Francisco to Santiago flights stop in Panama City the next most. Houston comes next as the third most popular layover location for San Francisco to Santiago flights.

Where are the least popular layover locations for San Francisco to Santiago flights?

The least popular layover on flights from San Francisco to Santiago is Dallas. Atlanta is the second least popular location for layovers on flights from San Francisco to Santiago.

What are some popular things to do or see while on a layover in Los Angeles?

Hollywood Bowl, Hollywood Walk of Fame, and L.A. Live are currently the most popular points of interest in Los Angeles at the moment. Hollywood Bowl, Hollywood Walk of Fame and L.A. Live are located about 12.5 mi, 11.7 mi, and 10.8 mi, respectively from Los Angeles if you are interested in checking them out. Travelers in need of a car in Los Angeles can rent one for about $41 per day.

What are some popular points of interest to see during a layover in Panama City?

The majority of Panama City visitors spend their time at Panama Old Cathedral, Amador Causeway, and Panama Canal. Those on a layover in Panama City interested in visiting Panama Old Cathedral, Amador Causeway, or Panama Canal can do so by traveling 13.2 mi, 14.7 mi, and 15.1 mi, respectively from Panama City Tocumen Intl. Those looking to explore during their layover in Panama City can rent a car from Panama City Tocumen Intl for about $13 per day.

What are points of interest worth seeing during a layover in Houston?

Most Houston visitors opt to spend their time at Space Center Houston, House of Blues Houston, and Revention Music Center. Space Center Houston, House of Blues Houston, and Revention Music Center can be accessed by traveling approximately 33.5 mi, 16.1 mi, and 15.5 mi, respectively from Houston George Bush Intcntl. Travelers can book a car rental at Houston George Bush Intcntl for about $41 per day to make their sightseeing more efficient.

What is the cheapest day to fly round-trip from San Francisco to Santiago?

Flying to your destination on a Friday can be more expensive, but this shouldn’t discourage you from finding affordable options to get to Santiago. Check prices with Cheapflights to find a great deal for your trip.

What is the cheapest month to fly from San Francisco to Santiago?

May can be a great time to fly to Santiago from San Francisco with a flight ticket averaging about $869. Cheapflights users have found deals in the month of May for as cheap as $544. The most expensive prices can be found in the month of December.

Most accurate provider : When it comes to deals on San Francisco-Santiago flights, users find the pricing of AranGrant to be most consistent on Cheapflights vs. AranGrant Users can find the same prices on San Francisco-Santiago flight deals on Cheapflights vs. AranGrant >95% of the time. Price accuracy is based on data collected from San Francisco-Santiago flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on San Francisco-Santiago flights, Cheapflights users trust AranGrant the most. AranGrant has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from San Francisco to Santiago that include hotel bookings?

Yes. In addition to deals on San Francisco to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from San Francisco to Santiago?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santiago.

Can I find deals for business class flights from San Francisco to Santiago?

Yes. Cheapflights offers flight deals from San Francisco to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$310+ Flights from San Francisco to Santiago

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

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Cheapflights Tip: The best prices from San Francisco to Santiago Arturo Merino Benitez are usually found in May or August, booked 3 days in advance, depart on a Wednesday or Monday and return on a Saturday

Cheap flight deals from San Francisco to Santiago

Most accurate provider	AranGrant 3 stars
Most trusted provider	AranGrant 3 stars
Round-trip from	$652 (Copa Airlines)
One-way from	$310 (Copa Airlines)
Popular in	December
Cheapest in	May
Average price	$732

Provider with most accurate pricing for San Francisco-Santiago Arturo Merino Benitez flight deals.

Search Deals

Provider most trusted by Cheapflights users for San Francisco-Santiago Arturo Merino Benitez flights.

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From San Francisco to Santiago Arturo Merino Benitez

Search Deals

One-way flight from San Francisco to Santiago Arturo Merino Benitez

Search Deals

Highest demand for flights based on searches. 11% potential increase in price ($117 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 5% potential price decrease ($42 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in May 2025

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Find flight deals from San Francisco to Santiago

Cheapest flights from San Francisco to Santiago
Explore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Sat 9/131:28 amSFO - SCL

1 stop14h 52mCopa Airlines

Sun 9/285:10 amSCL - SFO

1 stop22h 30mCopa Airlines

Deal found 4/30

$652

Wed 11/57:00 amSFO - SCL

1 stop19h 00mDelta

Wed 1/2111:55 pmSCL - SFO

1 stop15h 08mDelta

Deal found 5/1

$664

Fri 9/122:20 pmSFO - SCL

2 stops29h 10mAvianca

Fri 9/267:10 amSCL - SFO

2 stops19h 35mAvianca

Deal found 4/30

$665

Thu 10/166:00 amSFO - SCL

2 stops20h 00mLATAM Airlines

Wed 11/56:55 pmSCL - SFO

2 stops22h 05mLATAM Airlines

Deal found 4/30

$668

Sat 8/1612:13 pmSFO - SCL

1 stop15h 52mAmerican Airlines

Fri 8/299:55 pmSCL - SFO

1 stop28h 03mAmerican Airlines

Deal found 4/30

$728

Fri 9/263:51 pmSFO - SCL

1 stop35h 49mMultiple Airlines

Mon 10/65:15 amSCL - SFO

2 stops23h 31mMultiple Airlines

Deal found 4/30

$738

Tue 11/412:32 amSFO - SCL

1 stop27h 18mUnited Airlines

Wed 1/2110:45 pmSCL - SFO

1 stop23h 20mUnited Airlines

Deal found 4/30

$752

Mon 12/2211:50 amSFO - SCL

2 stops28h 25mAeromexico

Wed 12/3111:25 pmSCL - SFO

1 stop28h 45mAeromexico

Deal found 4/30

$948

Best flights from San Francisco to Santiago
Discover carefully curated flight deals from San Francisco to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 1, 2025.

Sat 9/131:28 amSFO - SCL

1 stop14h 52mCopa Airlines

Sun 9/285:10 amSCL - SFO

1 stop22h 30mCopa Airlines

Deal found 4/30

$652

Mon 9/2210:30 pmSFO - SCL

2 stops36h 00mLATAM Airlines

Tue 9/304:40 pmSCL - SFO

2 stops34h 12mLATAM Airlines

Deal found 4/30

$664

Fri 9/122:20 pmSFO - SCL

2 stops29h 10mAvianca

Fri 9/267:10 amSCL - SFO

2 stops19h 35mAvianca

Deal found 4/30

$665

Thu 8/281:00 pmSFO - SCL

1 stop14h 00mDelta

Sun 8/3110:45 pmSCL - SFO

1 stop22h 02mDelta

Deal found 4/30

$689

Sun 9/143:51 pmSFO - SCL

1 stop35h 49mMultiple Airlines

Sun 9/2811:35 amSCL - SFO

2 stops28h 25mMultiple Airlines

Deal found 4/30

$713

Sat 8/1612:13 pmSFO - SCL

1 stop15h 52mAmerican Airlines

Fri 8/299:55 pmSCL - SFO

1 stop28h 03mAmerican Airlines

Deal found 4/30

$728

Last-minute flights from San Francisco to Santiago
Discover last-minute flight deals from San Francisco to Santiago. Data last updated May 1, 2025 and is based on user searches.

Thu 5/81:37 amSFO - SCL

1 stop18h 07mCopa Airlines

Sun 5/254:11 amSCL - SFO

1 stop22h 29mCopa Airlines

Deal found 5/1

$652

Thu 5/81:37 amSFO - SCL

1 stop18h 07mMultiple Airlines

Sun 6/110:45 pmSCL - SFO

1 stop14h 25mMultiple Airlines

Deal found 4/30

$768

Sat 5/106:15 amSFO - SCL

2 stops19h 30mDelta

Sun 6/17:40 pmSCL - SFO

2 stops19h 05mDelta

Deal found 4/30

$849

Sun 5/112:20 pmSFO - SCL

2 stops29h 10mAvianca

Mon 5/192:30 pmSCL - SFO

2 stops36h 25mAvianca

Deal found 4/30

$667

Sun 5/116:05 amSFO - SCL

1 stop20h 45mLATAM Airlines

Mon 5/198:40 pmSCL - SFO

1 stop16h 35mLATAM Airlines

Deal found 4/30

$838

Fri 5/231:20 pmSFO - SCL

1 stop14h 35mAmerican Airlines

Mon 6/29:00 pmSCL - SFO

1 stop16h 52mAmerican Airlines

Deal found 4/30

$1,845

Tue 5/277:30 amSFO - SCL

1 stop20h 30mMultiple Airlines

Mon 6/911:55 pmSCL - SFO

2 stops25h 50mMultiple Airlines

Deal found 4/29

$726

Tue 5/277:30 amSFO - SCL

2 stops20h 15mDelta

Wed 6/117:20 amSCL - SFO

2 stops18h 52mDelta

Deal found 4/29

$818

Wed 5/2810:59 pmSFO - SCL

2 stops29h 36mLATAM Airlines

Tue 6/101:30 pmSCL - SFO

2 stops32h 17mLATAM Airlines

Deal found 4/29

$814

One-way flights from San Francisco to Santiago
Search for one-way flight options from San Francisco to Santiago. Find affordable one-way fares based on user searches. Data last updated May 1, 2025.

Sat 8/161:28 amSFO - SCL

1 stop22h 19mCopa Airlines

Deal found 4/29

$310

Wed 5/142:20 pmSFO - SCL

2 stops20h 05mAvianca

Deal found 4/30

$313

Wed 5/142:18 pmSFO - SCL

3 stops44h 07mMultiple Airlines

Deal found 4/30

$316

Tue 5/207:35 amSFO - SCL

1 stop20h 20mAmerican Airlines

Deal found 4/30

$405

Sun 6/111:59 pmSFO - SCL

2 stops25h 46mDelta

Deal found 4/30

$408

Sun 10/266:00 amSFO - SCL

3 stops27h 55mLATAM Airlines

Deal found 4/30

$464

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sat 9/13

1:28 am-11:40 pm

1 stop18h 12m

Santiago Arturo Merino Benitez

Sat 9/27

1:23 am-11:40 pm

1 stop26h 17m

$652

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 9/22

10:30 pm-2:30 pm

2 stops36h 00m

Santiago Arturo Merino Benitez

Tue 9/30

4:40 pm-10:52 pm

2 stops34h 12m

$664

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Fri 9/12

2:20 pm-11:30 pm

2 stops29h 10m

Santiago Arturo Merino Benitez

Fri 9/26

7:10 am-10:45 pm

2 stops19h 35m

$665

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Thu 8/28

1:00 pm-6:00 am

1 stop14h 00m

Santiago Arturo Merino Benitez

Sun 8/31

10:45 pm-5:47 pm

1 stop22h 02m

$689

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 9/14

3:51 pm-7:40 am

1 stop35h 49m

Santiago Arturo Merino Benitez

Sun 9/28

11:35 am-12:00 pm

2 stops28h 25m

$713

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sat 8/16

12:13 pm-7:05 am

1 stop15h 52m

Santiago Arturo Merino Benitez

Fri 8/29

9:55 pm-10:58 pm

1 stop28h 03m

$728

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sat 8/16

1:28 am-2:47 am

1 stop22h 19m

$310

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 5/14

2:20 pm-1:25 pm

2 stops20h 05m

$313

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 5/14

2:18 pm-1:25 pm

3 stops44h 07m

$316

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 5/20

7:35 am-6:55 am

1 stop20h 20m

$405

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 12 results

Compare providers for flights from San Francisco to Santiago

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Santiago in May.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*2 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
AranGrant	Price Accuracy3 stars	Trust Score*3 stars
Cheapfaremart	Price Accuracy-	Trust Score*1 star
CheapOair	Price Accuracy3 stars	Trust Score*3 stars
Mytrip	Price Accuracy3 stars	Trust Score*3 stars
Flightnetwork	Price Accuracy3 stars	Trust Score*3 stars
Justfly.com	Price Accuracy3 stars	Trust Score*2 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on San Francisco-Santiago flights, users find the pricing of AranGrant to be most consistent on Cheapflights vs. AranGrant Users can find the same prices on San Francisco-Santiago flight deals on Cheapflights vs. AranGrant >95% of the time. Price accuracy is based on data collected from San Francisco-Santiago flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on San Francisco-Santiago flights, Cheapflights users trust AranGrant the most. AranGrant has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Francisco to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from San Francisco with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santiago

How far ahead should I book a flight from San Francisco to Santiago?

Booking 3 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Francisco to Santiago?

Currently, April is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $752). Flying from San Francisco to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to SCL?

One of the essential ways to save on airfare from San Francisco to Santiago is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 18% on airfare.

What is the cheapest day to fly from San Francisco to Santiago?

Travelers seeking maximum savings on their San Francisco to Santiago flight should consider departing on Tuesday evenings when fares are most often at their lowest. Saturday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in Santiago by month

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

Temperature in Santiago by month

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

Reviews of airlines servicing Santiago

To help decide which airline to fly from San Francisco to Santiago, see what other customers have to say about Delta, LATAM Airlines and Copa Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta

8.0

Very good

7,934 reviews

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

LATAM Airlines

7.5

Good

1,767 reviews

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Copa Airlines

7.5

Good

1,415 reviews

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Avianca

6.7

Okay

2,317 reviews

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

What are the cheapest airlines flying from San Francisco to Santiago round-trip?
Currently priced at $652, Copa Airlines will fly you from San Francisco to Santiago and back. In addition to Copa Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from LATAM Airlines and Avianca - these airlines can fly you to your destination from $664 and $665, respectively. Copa Airlines is currently priced 24% below the average price you’ll pay for this route.
What are the cheapest airlines to fly from San Francisco to Santiago one-way?
$310 is the cheapest one-way deal found within the past few days, from Copa Airlines. You may also be able to find cheap deals on Avianca and American Airlines, with prices starting from $313 and $405, respectively.
Where are the most common layover locations when flying from San Francisco to Santiago?
Of the flights from San Francisco to Santiago that have layovers, most of them stop in Los Angeles. San Francisco to Santiago flights stop in Panama City the next most. Houston comes next as the third most popular layover location for San Francisco to Santiago flights.
What are some popular things to do or see while on a layover in Los Angeles?
Hollywood Bowl, Hollywood Walk of Fame, and L.A. Live are currently the most popular points of interest in Los Angeles at the moment. Hollywood Bowl, Hollywood Walk of Fame and L.A. Live are located about 12.5 mi, 11.7 mi, and 10.8 mi, respectively from Los Angeles if you are interested in checking them out. Travelers in need of a car in Los Angeles can rent one for about $41 per day.
What are some popular points of interest to see during a layover in Panama City?
The majority of Panama City visitors spend their time at Panama Old Cathedral, Amador Causeway, and Panama Canal. Those on a layover in Panama City interested in visiting Panama Old Cathedral, Amador Causeway, or Panama Canal can do so by traveling 13.2 mi, 14.7 mi, and 15.1 mi, respectively from Panama City Tocumen Intl. Those looking to explore during their layover in Panama City can rent a car from Panama City Tocumen Intl for about $13 per day.
What are points of interest worth seeing during a layover in Houston?
Most Houston visitors opt to spend their time at Space Center Houston, House of Blues Houston, and Revention Music Center. Space Center Houston, House of Blues Houston, and Revention Music Center can be accessed by traveling approximately 33.5 mi, 16.1 mi, and 15.5 mi, respectively from Houston George Bush Intcntl. Travelers can book a car rental at Houston George Bush Intcntl for about $41 per day to make their sightseeing more efficient.
Where are the least popular layover locations for San Francisco to Santiago flights?
The least popular layover on flights from San Francisco to Santiago is Dallas. Atlanta is the second least popular location for layovers on flights from San Francisco to Santiago.
Can I find deals for flights from San Francisco to Santiago that include hotel bookings?
Yes. In addition to deals on San Francisco to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from San Francisco to Santiago?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santiago.
Can I find deals for business class flights from San Francisco to Santiago?
Yes. Cheapflights offers flight deals from San Francisco to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from San Francisco to Santiago?
Currently, April is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $752). Flying from San Francisco to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Other flights to Santiago

Top 7 airlines flying from San Francisco to Santiago

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$473	Average$602	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$534	Average$782	FlexibilityNo cancel fee	On-time70%
United Airlines	Cheapest$622	Average$848	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$642	Average$848	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$658	Average$926	FlexibilityNo cancel fee	On-time71%
LATAM Airlines	Cheapest$660	Average$923	FlexibilityNo cancel fee	On-time81%
Aeromexico	Cheapest$765	Average$922	FlexibilityNo cancel fee	On-timeN/A

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$310+ Cheap flights from San Francisco (SFO) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/16. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from San Francisco to Santiago with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from San Francisco to Santiago Arturo Merino Benitez are usually found in May or August, booked 3 days in advance, depart on a Wednesday or Monday and return on a Saturday

Cheap flight deals from San Francisco to Santiago

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from San Francisco to Santiago

Cheapest flights from San Francisco to SantiagoExplore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Explore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.

Compare providers for flights from San Francisco to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Santiago in May.

Best time to book a flight from San Francisco to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from San Francisco with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santiago

How far ahead should I book a flight from San Francisco to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Santiago. Price data was last updated on April 25, 2025.

What is the cheapest month to book a flight from San Francisco to Santiago?

What is the cheapest time of day to fly from SFO to SCL?

Find hourly flight availability from San Francisco to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

What is the cheapest day to fly from San Francisco to Santiago?

Use this chart to determine the cheapest time to fly round-trip from San Francisco to Santiago. Price data was last updated on December 16, 2024.

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

Reviews of airlines servicing Santiago

To help decide which airline to fly from San Francisco to Santiago, see what other customers have to say about Delta, LATAM Airlines and Copa Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from San Francisco to Santiago round-trip?

What are the cheapest airlines to fly from San Francisco to Santiago one-way?

Where are the most common layover locations when flying from San Francisco to Santiago?

What are some popular things to do or see while on a layover in Los Angeles?

What are some popular points of interest to see during a layover in Panama City?

What are points of interest worth seeing during a layover in Houston?

Where are the least popular layover locations for San Francisco to Santiago flights?

Can I find deals for flights from San Francisco to Santiago that include hotel bookings?

How can I find direct flights from San Francisco to Santiago?

Can I find deals for business class flights from San Francisco to Santiago?

What is the cheapest month to book a flight from San Francisco to Santiago?

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Alternative routes for San Francisco to Santiago

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Top 7 airlines flying from San Francisco to Santiago

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Cheapest flights from San Francisco to Santiago
Explore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.