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$313+ Cheap flights from San Francisco (SFO) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/21. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — SCL
Feb 25 — Mar 41
Wed 2/25
Wed 3/4
1 adult, Economy
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Cheap flight deals from San Francisco to Santiago

Cheapest flights from San Francisco to Santiago
Explore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.

This Copa Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/121:12 am
SFO
-
SCL
1 stop19h 14m
Copa Airlines
Tue 5/1911:17 am
SCL
-
SFO
1 stop15h 23m
Copa Airlines
Deal found 1/25$578
This FlightHub deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:05 am
SFO
-
SCL
1 stop15h 30m
LATAM Airlines
Wed 9/3011:25 pm
SCL
-
SFO
1 stop16h 34m
LATAM Airlines
Deal found 1/24$590
This FlightHub deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/2311:05 am
SFO
-
SCL
1 stop15h 30m
LATAM Airlines
Tue 9/85:40 am
SCL
-
SFO
2 stops21h 32m
LATAM Airlines
Deal found 1/25$609
This Copa Airlines deal was found by Cheapflights users on 1/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/11:12 am
SFO
-
SCL
1 stop24h 51m
Copa Airlines
Wed 5/2711:17 am
SCL
-
SFO
1 stop15h 23m
Copa Airlines
Deal found 1/23$611
This KAYAK deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:00 am
SFO
-
SCL
2 stops28h 35m
LATAM Airlines
Sun 8/1611:05 pm
SCL
-
SFO
2 stops38h 07m
LATAM Airlines
Deal found 1/25$615
This Copa Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:06 pm
SFO
-
SCL
1 stop23h 37m
Copa Airlines
Mon 5/1111:17 am
SCL
-
SFO
1 stop15h 23m
Copa Airlines
Deal found 1/25$618
This Delta deal was found by Cheapflights users on 1/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:00 am
SFO
-
SCL
1 stop20h 50m
Delta
Sun 6/1410:30 am
SCL
-
SFO
2 stops32h 53m
Delta
Deal found 1/23$620
This LATAM Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:45 pm
SFO
-
SCL
2 stops26h 15m
LATAM Airlines
Fri 10/168:40 pm
SCL
-
SFO
1 stop26h 57m
LATAM Airlines
Deal found 1/25$623
This KAYAK deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/102:00 pm
SFO
-
SCL
2 stops36h 00m
LATAM Airlines
Thu 10/2211:25 pm
SCL
-
SFO
1 stop19h 43m
LATAM Airlines
Deal found 1/24$626
This FlightHub deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/411:05 am
SFO
-
SCL
1 stop15h 30m
LATAM Airlines
Wed 9/97:45 am
SCL
-
SFO
2 stops19h 27m
LATAM Airlines
Deal found 1/24$629
This Mytrip deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/22:15 pm
SFO
-
SCL
3 stops34h 10m
Multiple Airlines
Thu 4/166:10 am
SCL
-
SFO
2 stops20h 45m
Multiple Airlines
Deal found 1/24$642

Find flight deals from San Francisco to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$578
(Copa Airlines)

One-way from

$313
(Kiwi.com)

Popular in

July

Cheapest in

January

Average price

$683
Provider with most accurate pricing for San Francisco-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Francisco-Santiago Arturo Merino Benitez flights.
Search Deals
From San Francisco to Santiago Arturo Merino Benitez
Search Deals
One-way flight from San Francisco to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($49 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.

Fly from

San Francisco

Fly to

Santiago

Route

Depart

Return

Price

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 5/12

1:12 am-11:26 pm

1 stop19h 14m

Santiago Arturo Merino Benitez

Tue 5/19

11:17 am-11:40 pm

1 stop15h 23m

$578

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Fri 5/1

1:12 am-5:03 am

1 stop24h 51m

Santiago Arturo Merino Benitez

Wed 5/27

11:17 am-11:40 pm

1 stop15h 23m

$611

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 5/6

1:12 am-3:00 am

1 stop22h 48m

Santiago Arturo Merino Benitez

Sun 5/10

2:22 am-11:40 pm

1 stop24h 18m

$618

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Thu 5/28

7:00 am-6:50 am

1 stop20h 50m

Santiago Arturo Merino Benitez

Sun 6/14

10:30 am-4:23 pm

2 stops32h 53m

$620

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Thu 6/4

11:05 am-5:35 am

1 stop15h 30m

Santiago Arturo Merino Benitez

Sun 6/21

10:30 am-6:35 pm

2 stops35h 05m

$620

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 5/13

6:00 am-5:35 am

2 stops20h 35m

Santiago Arturo Merino Benitez

Tue 5/19

11:25 pm-3:11 pm

1 stop18h 46m

$648

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 3/24

6:00 am-5:35 am

1 stop19h 35m

Santiago Arturo Merino Benitez

Wed 4/8

7:15 am-11:00 pm

1 stop18h 45m

$657

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 4/20

6:15 am-6:50 am

1 stop21h 35m

Santiago Arturo Merino Benitez

Mon 5/4

8:30 pm-8:49 pm

1 stop27h 19m

$663

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 3/29

11:29 pm-7:00 am

2 stops27h 31m

Santiago Arturo Merino Benitez

Fri 4/17

7:15 am-11:20 pm

2 stops19h 05m

$685

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 4/1

6:00 am-8:15 am

1 stop22h 15m

Santiago Arturo Merino Benitez

Sat 4/18

10:55 pm-1:23 am

1 stop29h 28m

$685

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/24

Showing 1-10 of 18 results
1
2

Compare providers for flights from San Francisco to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Santiago in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*2 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
OvagoPrice Accuracy2 starsTrust Score*3 stars
SmartFaresPrice Accuracy1 starTrust Score*1 star
CheapfaremartPrice Accuracy-Trust Score*1 star
JustAirTicketPrice Accuracy-Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on San Francisco-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Francisco-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Francisco to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santiago

How far ahead should I book a flight from San Francisco to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Santiago. Price data was last updated on January 23, 2026.

Booking 23 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Francisco to Santiago?

Currently, September is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $480). Flying from San Francisco to Santiago in June is currently the most expensive (average of $663). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated January 26, 2026.
Peruse reviews from past customers who have flown with Delta, Copa Airlines, and LATAM Airlines from San Francisco to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,113 reviews

Overall

7.9

Boarding

8.1

Comfort

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
7.9
Good
8,113 reviews
Delta
7.9
Good
8,113 reviews

Overall

7.9

Boarding

8.1

Comfort

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.6
Good
1,558 reviews
Delta
7.9
Good
8,113 reviews

Overall

7.9

Boarding

8.1

Comfort

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,912 reviews
Delta
7.9
Good
8,113 reviews

Overall

7.9

Boarding

8.1

Comfort

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
9,200 reviews
Delta
7.9
Good
8,113 reviews

Overall

7.9

Boarding

8.1

Comfort

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
11,189 reviews
Delta
7.9
Good
8,113 reviews

Overall

7.9

Boarding

8.1

Comfort

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Francisco to Santiago?

    A quick flight from San Francisco to Santiago can take about 19h 14m. Copa Airlines provides one of the quickest options available for as low as $578. There are 5918 mi between San Francisco and Santiago. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from San Francisco to Santiago round-trip?

    Currently priced at $366, Avianca will fly you from San Francisco to Santiago and back. In addition to Avianca, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from United Airlines and American Airlines - these airlines can fly you to your destination from $494 and $498, respectively. Avianca is currently priced 53% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from San Francisco to Santiago one-way?

    $191 is the cheapest one-way deal found within the past few days, from Avianca. You may also be able to find cheap deals on United Airlines and Copa Airlines, with prices starting from $248 and $299, respectively.

  • Where are the most common layover locations when flying from San Francisco to Santiago?

    Of the flights from San Francisco to Santiago that have layovers, most of them stop in Los Angeles. San Francisco to Santiago flights stop in Houston the next most. Atlanta comes next as the third most popular layover location for San Francisco to Santiago flights.

  • What are some popular things to do or see while on a layover in Los Angeles?

    Hollywood Bowl, Hollywood Walk of Fame, and L.A. Live are currently the most popular points of interest in Los Angeles at the moment. Hollywood Bowl, Hollywood Walk of Fame and L.A. Live are located about 12.5 mi, 11.7 mi, and 10.8 mi, respectively from Los Angeles if you are interested in checking them out. Travelers in need of a car in Los Angeles can rent one for about $40 per day.

  • What are some popular points of interest to see during a layover in Houston?

    The majority of Houston visitors spend their time at Space Center Houston, House of Blues Houston, and Revention Music Center. Those on a layover in Houston interested in visiting Space Center Houston, House of Blues Houston, or Revention Music Center can do so by traveling 33.5 mi, 16.1 mi, and 15.5 mi, respectively from Houston George Bush Intcntl. Those looking to explore during their layover in Houston can rent a car from Houston George Bush Intcntl for about $32 per day.

  • What are points of interest worth seeing during a layover in Atlanta?

    Most Atlanta visitors opt to spend their time at Georgia Aquarium, Fox Theatre, and Centennial Olympic Park. Georgia Aquarium, Fox Theatre, and Centennial Olympic Park can be accessed by traveling approximately 8.6 mi, 9.3 mi, and 8.4 mi, respectively from Atlanta Hartsfield-Jackson. Travelers can book a car rental at Atlanta Hartsfield-Jackson for about $51 per day to make their sightseeing more efficient.

  • Where are the least popular layover locations for San Francisco to Santiago flights?

    The least popular layover on flights from San Francisco to Santiago is Panama City. Dallas is the second least popular location for layovers on flights from San Francisco to Santiago.

  • Can I find deals for flights from San Francisco to Santiago that include hotel bookings?

    Yes. In addition to deals on San Francisco to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santiago.

  • Can I find deals for business class flights from San Francisco to Santiago?

    Yes. Cheapflights offers flight deals from San Francisco to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Santiago?

    Currently, September is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $480). Flying from San Francisco to Santiago in June is currently the most expensive (average of $663). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for San Francisco to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from San Francisco to Santiago

Discover the top 7 airlines that operate flights from San Francisco to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$366Average$642FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$494Average$731FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$498Average$863FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$501Average$697FlexibilityNo cancel feeOn-time70%
DeltaCheapest$569Average$820FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$589Average$839FlexibilityNo cancel feeOn-time81%
AeromexicoCheapest$765Average$1,073FlexibilityNo cancel feeOn-timeN/A

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