$351+ Cheap flights from San Francisco (SFO) to Santiago (SCL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/30. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — SCL
Dec 4 — Dec 111
Round-trip
1 adult, Economy
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Find cheap flights from San Francisco to Santiago with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Santiago
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Cheapest flights from San Francisco to SantiagoExplore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
Explore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
This FlightHub deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:05 am -
2 stops17h 15m
Tue 12/17:40 am -
2 stops19h 54m
Deal found 11/3![LATAM Airlines logo]()
$910
This FlightHub deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:00 am -
2 stops18h 05m
Wed 11/257:40 am -
2 stops19h 47m
Deal found 11/1![LATAM Airlines logo]()
$914
This FlightHub deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/247:05 am -
2 stops17h 15m
Mon 12/219:55 pm -
2 stops19h 04m
Deal found 11/1![LATAM Airlines logo]()
$933
This Avianca deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:15 pm -
2 stops20h 55m
Fri 4/26:40 am -
2 stops19h 55m
Deal found 10/30![Avianca logo]()
$944
This LATAM Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:05 am -
2 stops17h 15m
Tue 12/88:25 pm -
2 stops19h 30m
Deal found 11/3![LATAM Airlines logo]()
$949
This Avianca deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1211:00 pm -
2 stops21h 05m
Tue 4/66:40 am -
2 stops18h 55m
Deal found 11/1![Avianca logo]()
$956
This FlightHub deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/262:47 pm -
2 stops19h 13m
Wed 12/2310:15 am -
2 stops19h 08m
Deal found 11/1![LATAM Airlines logo]()
$959
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/129:13 am -
2 stops18h 32m
Tue 4/68:35 pm -
1 stop17h 27m
Deal found 10/30![American Airlines logo]()
$968
This Mytrip deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:30 am -
3 stops36h 38m
Thu 12/107:30 am -
2 stops33h 25m
Deal found 11/2![Multiple Airlines logo]()
$970
Best flights from San Francisco to SantiagoDiscover carefully curated flight deals from San Francisco to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
Discover carefully curated flight deals from San Francisco to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/171:10 pm -
2 stops20h 50m
Thu 2/412:30 am -
2 stops23h 23m
Deal found 11/3![Delta logo]()
$1,026
This Copa Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:36 pm -
1 stop26h 12m
Mon 12/73:48 am -
1 stop18h 37m
Deal found 11/3![Copa Airlines logo]()
$1,029
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/247:15 am -
1 stop20h 35m
Mon 12/2110:45 pm -
1 stop25h 00m
Deal found 11/1![United Airlines logo]()
$1,034
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/1511:45 am -
1 stop14h 55m
Thu 2/411:55 pm -
1 stop21h 03m
Deal found 11/3![Delta logo]()
$1,026
This Copa Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:36 pm -
1 stop23h 00m
Tue 12/112:20 pm -
1 stop34h 05m
Deal found 11/2![Copa Airlines logo]()
$1,029
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/11:00 pm -
2 stops21h 00m
Fri 1/157:40 am -
2 stops18h 42m
Deal found 11/2![Delta logo]()
$1,026
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/154:59 pm -
2 stops17h 01m
Wed 2/39:55 pm -
2 stops18h 07m
Deal found 11/3![Delta logo]()
$1,026
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/88:00 am -
1 stop17h 40m
Fri 1/229:50 pm -
1 stop20h 04m
Deal found 10/30![Delta logo]()
$1,026
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/167:00 am -
2 stops17h 20m
Wed 2/39:55 pm -
2 stops18h 07m
Deal found 11/3![Delta logo]()
$1,026
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/177:00 am -
1 stop17h 35m
Wed 2/311:10 pm -
1 stop16h 34m
Deal found 11/3![Delta logo]()
$1,026
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/111:49 am -
1 stop14h 51m
Wed 12/911:55 pm -
1 stop20h 45m
Deal found 11/1![Delta logo]()
$1,042
Last-minute flights from San Francisco to SantiagoDiscover last-minute flight deals from San Francisco to Santiago. Data last updated November 4, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Santiago. Data last updated November 4, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:15 pm -
2 stops20h 55m
Fri 4/26:40 am -
2 stops19h 55m
Deal found 10/30![Avianca logo]()
$944
This Avianca deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1211:00 pm -
2 stops21h 05m
Tue 4/66:40 am -
2 stops18h 55m
Deal found 11/1![Avianca logo]()
$956
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/129:13 am -
2 stops18h 32m
Tue 4/68:35 pm -
1 stop17h 27m
Deal found 10/30![American Airlines logo]()
$968
This FlightHub deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:00 am -
2 stops18h 05m
Wed 11/257:40 am -
2 stops19h 47m
Deal found 11/1![LATAM Airlines logo]()
$914
This FlightHub deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/247:05 am -
2 stops17h 15m
Mon 12/219:55 pm -
2 stops19h 04m
Deal found 11/1![LATAM Airlines logo]()
$933
This FlightHub deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:05 am -
2 stops17h 15m
Tue 12/17:40 am -
2 stops19h 54m
Deal found 11/3![LATAM Airlines logo]()
$910
This FlightHub deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/262:47 pm -
2 stops19h 13m
Wed 12/2310:15 am -
2 stops19h 08m
Deal found 11/1![LATAM Airlines logo]()
$959
This LATAM Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:05 am -
2 stops17h 15m
Tue 12/88:25 pm -
2 stops19h 30m
Deal found 11/3![LATAM Airlines logo]()
$949
This Mytrip deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:30 am -
3 stops36h 38m
Thu 12/107:30 am -
2 stops33h 25m
Deal found 11/2![Multiple Airlines logo]()
$970
One-way flights from San Francisco to SantiagoSearch for one-way flight options from San Francisco to Santiago. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
Search for one-way flight options from San Francisco to Santiago. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/309:23 pm -
3 stops34h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Multiple Airlines logo]()
$351
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/316:15 am -
3 stops26h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Multiple Airlines logo]()
$358
This SmartFares deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/228:25 am -
1 stop17h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Air Canada logo]()
$418
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/246:15 am -
3 stops41h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Multiple Airlines logo]()
$437
This Air Canada deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/188:25 am -
1 stop17h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Air Canada logo]()
$447
This Air Canada deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/176:30 am -
2 stops24h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Air Canada logo]()
$452
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:30 pm -
3 stops44h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Multiple Airlines logo]()
$466
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/296:15 am -
3 stops47h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Multiple Airlines logo]()
$470
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/116:15 am -
3 stops25h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Multiple Airlines logo]()
$487
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2211:29 pm -
3 stops43h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Multiple Airlines logo]()
$490
Find flight deals from San Francisco to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 4, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $879 (eDestinos) |
One-way from | $351 (Kiwi.com) |
Popular in | December |
Cheapest in | January |
Average price | $1,043 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Mon 3/22
6:30 am-11:15 am
2 stops24h 45m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$451
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Sun 4/25
6:00 am-3:31 am
2 stops18h 31m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$492
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Fri 1/1
6:31 am-5:57 am
2 stops18h 26m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$526
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Tue 11/10
6:02 am-3:38 am
3 stops40h 36m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$535
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Thu 3/18
11:30 am-5:25 am
3 stops37h 55m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$574
Quickest round-trip
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Sun 11/15
12:33 am-8:15 pm
1 stop14h 42m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$590
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Mon 11/16
12:33 am-2:48 am
1 stop21h 15m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$590
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Mon 11/9
12:33 am-12:24 am
1 stop18h 51m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$590
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Thu 11/12
12:33 am-3:38 am
1 stop22h 05m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$590
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Tue 12/1
2:59 pm-6:00 pm
2 stops22h 01m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$592
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Santiago in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on San Francisco-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on San Francisco-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from San Francisco-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from San Francisco with our price prediction graph.
SFO-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Santiago
Prices
More
How far ahead should I book a flight from San Francisco to Santiago?
Booking 40 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from San Francisco to Santiago?
Currently, January is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $675). Flying from San Francisco to Santiago in December is currently the most expensive (average of $1,160). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Francisco to Santiago?
Airfare is typical for this route at the moment.
San Francisco to Santiago flights typically cost between $838 and $1,293 in February.The cheapest round-trip price found within the last 5 days was $879 on Multiple Airlines (Feb 9-Feb 21).
What’s the top layover airport for flights from San Francisco to Santiago?
Share of 1-stop round-trip flights from San Francisco to Santiago chosen by Cheapflights users in the past 12 months, using the same layover each way.
Los Angeles (LAX) – chosen by Cheapflights users on 50% of 1-stop itineraries from San Francisco to Santiago on Cheapflights.
What’s the cheapest layover airport for flights from San Francisco to Santiago?
Average round-trip fare for 1-stop flights from San Francisco to Santiago, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Dallas (DFW) is the most affordable 1-stop option, with an average round-trip price of $483.
What’s the fastest layover option from San Francisco to Santiago?
Shortest average travel time for 1-stop one-way flights from San Francisco to Santiago, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Los Angeles (LAX) have the shortest average one-way travel time for 1-stop routes: 14h 50m.
Which airport typically offers the quickest layover for flights from San Francisco to Santiago?
Average layover duration for 1-stop one-way flights from San Francisco to Santiago, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Dallas (DFW) offer the fastest connection on this route, with an average layover time of 2h 15m.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated November 4, 2026.
Peruse reviews from past customers who have flown with Delta,Copa Airlines, andLATAM Airlines from San Francisco to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Food
7.2
Comfort
7.8
Overall
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Crew
8.5
Food
7.2
Comfort
7.8
Overall
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Crew
8.5
Food
7.2
Comfort
7.8
Overall
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Crew
8.5
Food
7.2
Comfort
7.8
Overall
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Crew
8.5
Food
7.2
Comfort
7.8
Overall
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Crew
8.5
Food
7.2
Comfort
7.8
Overall
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for San Francisco to Santiago
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San Francisco and Santiago flights
Browse other San Francisco and Santiago flight options. Last updated on November 4, 2026.
Other flights from San Francisco
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Check out other popular destinations found by fellow travelers in 2026
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Top 8 airlines flying from San Francisco to Santiago
Discover the top 8 airlines that operate flights from San Francisco to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$290 | Average$893 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$482 | Average$2,192 | FlexibilityNo cancel fee | On-time67% | |
| Cheapest$494 | Average$869 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$502 | Average$983 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$585 | Average$1,040 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$595 | Average$1,044 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$613 | Average$849 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$919 | Average$1,298 | FlexibilityNo cancel fee | On-timeN/A |