$65+ Cheap flights from Missouri to Santa Ana, CA (SNA)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SNA
May 29 — Jun 51
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Missouri to Santa Ana with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to Santa Ana
Cheapest
Best
Last-minute
One-way
Cheapest flights from Missouri to Santa AnaExplore the most affordable flight options available from Missouri to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.
Explore the most affordable flight options available from Missouri to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.
This Frontier deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:34 pm
MCI
- SNA
1 stop20h 35m
Frontier
Fri 6/59:54 am
SNA
- MCI
1 stop25h 55m
Frontier
Deal found 4/28![Frontier logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/62:34 pm
MCI
- SNA
1 stop20h 35m
Frontier
Mon 6/88:10 pm
SNA
- MCI
2 stops14h 50m
Frontier
Deal found 4/28![Frontier logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/302:34 pm
MCI
- SNA
1 stop20h 35m
Multiple Airlines
Thu 6/113:34 pm
SNA
- MCI
2 stops23h 47m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:08 pm
STL
- SNA
1 stop15h 01m
Frontier
Mon 6/14:20 pm
SNA
- STL
2 stops20h 28m
Frontier
Deal found 4/28![Frontier logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:34 pm
MCI
- SNA
1 stop20h 35m
Multiple Airlines
Fri 6/54:33 pm
SNA
- MCI
2 stops19h 16m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:27 pm
STL
- SNA
2 stops24h 11m
Multiple Airlines
Mon 6/88:10 pm
SNA
- STL
1 stop18h 55m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$296
This Expedia deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1012:36 pm
STL
- SNA
1 stop25h 43m
Frontier
Thu 5/149:54 am
SNA
- STL
1 stop7h 29m
Frontier
Deal found 4/25![Frontier logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/302:34 pm
MCI
- SNA
1 stop20h 35m
Multiple Airlines
Wed 6/107:30 am
SNA
- MCI
2 stops27h 30m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$316
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/33:55 pm
MCI
- SNA
1 stop6h 39m
Delta
Tue 6/99:50 am
SNA
- MCI
1 stop5h 16m
Delta
Deal found 4/27![Delta logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:08 pm
STL
- SNA
1 stop15h 01m
Frontier
Sat 5/309:54 am
SNA
- STL
1 stop7h 29m
Frontier
Deal found 4/24![Frontier logo]()
$317
This Trip.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:36 pm
STL
- SNA
1 stop25h 43m
Frontier
Sun 5/109:54 am
SNA
- STL
1 stop7h 29m
Frontier
Deal found 4/28![Frontier logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:30 pm
STL
- SNA
2 stops17h 58m
Multiple Airlines
Sat 5/309:54 am
SNA
- STL
1 stop7h 29m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$320
Best flights from Missouri to Santa AnaDiscover carefully curated flight deals from Missouri to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 29, 2026.
Discover carefully curated flight deals from Missouri to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 29, 2026.
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:00 am
MCI
- SNA
1 stop5h 07m
United Airlines
Wed 5/2710:20 am
SNA
- MCI
2 stops9h 27m
United Airlines
Deal found 4/26![United Airlines logo]()
$367
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/17:25 pm
MCI
- SNA
1 stop4h 55m
Southwest
Wed 7/811:10 am
SNA
- MCI
2 stops8h 50m
Southwest
Deal found 4/27![Southwest logo]()
$367
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/93:57 pm
STL
- SNA
1 stop8h 31m
Delta
Tue 6/232:00 pm
SNA
- STL
1 stop7h 56m
Delta
Deal found 4/25![Delta logo]()
$387
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/27:06 am
STL
- SNA
1 stop8h 26m
American Airlines
Mon 7/64:30 pm
SNA
- STL
1 stop5h 29m
American Airlines
Deal found 4/25![American Airlines logo]()
$497
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/241:50 pm
SGF
- SNA
2 stops20h 15m
Multiple Airlines
Thu 5/285:48 pm
SNA
- SGF
1 stop24h 13m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$563
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/295:40 am
SGF
- SNA
2 stops10h 16m
United Airlines
Tue 9/16:45 am
SNA
- SGF
1 stop9h 15m
United Airlines
Deal found 4/28![United Airlines logo]()
$400
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:00 pm
STL
- SNA
1 stop6h 54m
Delta
Sat 5/302:00 pm
SNA
- STL
1 stop7h 59m
Delta
Deal found 4/26![Delta logo]()
$409
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/282:10 pm
MCI
- SNA
2 stops6h 10m
Southwest
Tue 8/41:00 pm
SNA
- MCI
1 stop7h 30m
Southwest
Deal found 4/26![Southwest logo]()
$412
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/108:35 am
STL
- SNA
2 stops8h 20m
Southwest
Tue 6/167:00 am
SNA
- STL
2 stops8h 45m
Southwest
Deal found 4/25![Southwest logo]()
$442
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/129:00 am
COU
- SNA
1 stop6h 18m
United Airlines
Sun 5/2410:37 am
SNA
- COU
1 stop9h 22m
United Airlines
Deal found 4/24![United Airlines logo]()
$453
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/162:28 pm
STL
- SNA
1 stop6h 02m
Delta
Mon 6/222:00 pm
SNA
- STL
1 stop7h 56m
Delta
Deal found 4/27![Delta logo]()
$488
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/195:50 am
MCI
- SNA
1 stop5h 40m
Southwest
Sun 6/2112:25 pm
SNA
- MCI
1 stop7h 40m
Southwest
Deal found 4/26![Southwest logo]()
$483
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/255:00 pm
STL
- SNA
1 stop7h 00m
Delta
Sat 8/12:00 pm
SNA
- STL
1 stop7h 40m
Delta
Deal found 4/25![Delta logo]()
$497
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:00 am
MCI
- SNA
2 stops9h 45m
United Airlines
Tue 6/164:00 pm
SNA
- MCI
1 stop5h 25m
United Airlines
Deal found 4/28![United Airlines logo]()
$498
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:16 am
COU
- SNA
2 stops10h 18m
American Airlines
Wed 6/36:45 am
SNA
- COU
2 stops8h 04m
American Airlines
Deal found 4/27![American Airlines logo]()
$623
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/308:35 am
STL
- SNA
2 stops8h 20m
Southwest
Mon 7/612:10 pm
SNA
- STL
2 stops10h 00m
Southwest
Deal found 4/25![Southwest logo]()
$497
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:21 am
STL
- SNA
1 stop8h 35m
Delta
Mon 7/65:03 pm
SNA
- STL
1 stop5h 36m
Delta
Deal found 4/24![Delta logo]()
$497
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/234:45 pm
STL
- SNA
1 stop5h 55m
United Airlines
Wed 5/271:08 pm
SNA
- STL
1 stop6h 02m
United Airlines
Deal found 4/28![United Airlines logo]()
$498
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2810:53 am
COU
- SNA
1 stop9h 59m
United Airlines
Wed 6/31:55 pm
SNA
- COU
1 stop7h 11m
United Airlines
Deal found 4/27![United Airlines logo]()
$501
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:45 am
STL
- SNA
2 stops8h 35m
Southwest
Mon 5/181:00 pm
SNA
- STL
2 stops7h 40m
Southwest
Deal found 4/25![Southwest logo]()
$525
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/94:00 pm
SGF
- SNA
1 stop8h 29m
Delta
Sat 5/168:00 am
SNA
- SGF
2 stops12h 19m
Delta
Deal found 4/27![Delta logo]()
$529
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/164:15 pm
MCI
- SNA
1 stop7h 40m
Southwest
Fri 7/171:30 pm
SNA
- MCI
2 stops8h 25m
Southwest
Deal found 4/28![Southwest logo]()
$528
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/129:00 am
COU
- SNA
1 stop6h 18m
United Airlines
Tue 5/266:20 pm
SNA
- COU
2 stops13h 58m
United Airlines
Deal found 4/24![United Airlines logo]()
$530
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:00 am
MCI
- SNA
1 stop5h 07m
United Airlines
Tue 7/1410:20 am
SNA
- MCI
2 stops10h 58m
United Airlines
Deal found 4/28![United Airlines logo]()
$532
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/612:07 pm
SGF
- SNA
2 stops10h 27m
Delta
Sun 6/78:00 am
SNA
- SGF
2 stops12h 09m
Delta
Deal found 4/24![Delta logo]()
$640
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/123:10 pm
COU
- SNA
1 stop9h 25m
United Airlines
Sat 5/1611:00 am
SNA
- COU
1 stop7h 49m
United Airlines
Deal found 4/27![United Airlines logo]()
$543
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:00 am
MCI
- SNA
1 stop5h 07m
United Airlines
Fri 5/294:00 pm
SNA
- MCI
1 stop5h 25m
United Airlines
Deal found 4/24![United Airlines logo]()
$563
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/129:00 am
COU
- SNA
1 stop8h 03m
United Airlines
Mon 5/257:49 pm
SNA
- COU
2 stops12h 29m
United Airlines
Deal found 4/24![United Airlines logo]()
$570
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:22 pm
SGF
- SNA
2 stops16h 45m
United Airlines
Wed 5/2710:20 am
SNA
- SGF
1 stop8h 23m
United Airlines
Deal found 4/26![United Airlines logo]()
$571
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/134:50 pm
SGF
- SNA
1 stop6h 41m
United Airlines
Sun 5/1711:00 am
SNA
- SGF
1 stop7h 42m
United Airlines
Deal found 4/28![United Airlines logo]()
$594
Last-minute flights from Missouri to Santa AnaDiscover last-minute flight deals from Missouri to Santa Ana. Data last updated April 29, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Santa Ana. Data last updated April 29, 2026 and is based on user searches.
This Trip.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:34 pm
MCI
- SNA
1 stop20h 35m
Frontier
Sat 5/99:54 am
SNA
- MCI
1 stop25h 55m
Frontier
Deal found 4/26![Frontier logo]()
$323
This Trip.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:36 pm
STL
- SNA
1 stop25h 43m
Frontier
Sun 5/109:54 am
SNA
- STL
1 stop7h 29m
Frontier
Deal found 4/28![Frontier logo]()
$318
This Trip.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:08 pm
STL
- SNA
1 stop15h 01m
Multiple Airlines
Tue 5/198:05 am
SNA
- STL
1 stop8h 40m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$322
This Expedia deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1012:36 pm
STL
- SNA
1 stop25h 43m
Frontier
Thu 5/149:54 am
SNA
- STL
1 stop7h 29m
Frontier
Deal found 4/25![Frontier logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:30 pm
STL
- SNA
2 stops17h 58m
Multiple Airlines
Sat 5/309:54 am
SNA
- STL
1 stop7h 29m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$320
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:08 pm
STL
- SNA
1 stop15h 01m
Frontier
Sat 5/309:54 am
SNA
- STL
1 stop7h 29m
Frontier
Deal found 4/24![Frontier logo]()
$317
This Frontier deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:34 pm
MCI
- SNA
1 stop20h 35m
Frontier
Fri 6/59:54 am
SNA
- MCI
1 stop25h 55m
Frontier
Deal found 4/28![Frontier logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:08 pm
STL
- SNA
1 stop15h 01m
Frontier
Mon 6/14:20 pm
SNA
- STL
2 stops20h 28m
Frontier
Deal found 4/28![Frontier logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:34 pm
MCI
- SNA
1 stop20h 35m
Multiple Airlines
Fri 6/54:33 pm
SNA
- MCI
2 stops19h 16m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/302:34 pm
MCI
- SNA
1 stop20h 35m
Multiple Airlines
Thu 6/113:34 pm
SNA
- MCI
2 stops23h 47m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/302:34 pm
MCI
- SNA
1 stop20h 35m
Multiple Airlines
Wed 6/107:30 am
SNA
- MCI
2 stops27h 30m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/302:34 pm
MCI
- SNA
1 stop20h 35m
Frontier
Fri 6/122:24 pm
SNA
- MCI
2 stops20h 36m
Frontier
Deal found 4/27![Frontier logo]()
$321
One-way flights from Missouri to Santa AnaSearch for one-way flight options from Missouri to Santa Ana. Find affordable one-way fares based on user searches. Data last updated April 29, 2026.
Search for one-way flight options from Missouri to Santa Ana. Find affordable one-way fares based on user searches. Data last updated April 29, 2026.
This Trip.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:08 pm
STL
- SNA
1 stop15h 01m
Frontier
Deal found 4/27![Frontier logo]()
$65
This CheapOair deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:51 pm
STL
- SNA
1 stop19h 28m
Frontier
Deal found 4/26![Frontier logo]()
$106
This CheapOair deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/177:46 pm
STL
- SNA
1 stop18h 48m
Frontier
Deal found 4/28![Frontier logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/68:08 pm
STL
- SNA
1 stop15h 01m
Frontier
Deal found 4/28![Frontier logo]()
$144
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:51 pm
STL
- SNA
2 stops22h 44m
Frontier
Deal found 4/26![Frontier logo]()
$149
This CheapOair deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:08 pm
STL
- SNA
1 stop15h 01m
Frontier
Deal found 4/25![Frontier logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/185:27 pm
STL
- SNA
3 stops53h 38m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/68:08 pm
STL
- SNA
2 stops16h 30m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$158
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/111:45 pm
MCI
- SNA
1 stop20h 24m
Frontier
Deal found 4/28![Frontier logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/136:16 pm
MCI
- SNA
2 stops42h 03m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$161
This CheapOair deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1412:36 pm
STL
- SNA
1 stop25h 43m
Frontier
Deal found 4/28![Frontier logo]()
$161
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:00 am
MCI
- SNA
2 stops8h 06m
United Airlines
Deal found 4/24![United Airlines logo]()
$164
Find flight deals from Missouri to Santa Ana
Keep the following information in mind while searching for Missouri to Santa Ana flight deals. Data was last updated April 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $211 (Frontier) |
One-way from | $65 (Trip.com) |
Popular in | March |
Cheapest in | September |
Average price | $418 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
Use the filters below to find and compare flights from Missouri to Santa Ana that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Kansas CitySanta Ana
MCI - SNA
MCISNA
Kansas City
Sun 5/24
6:00 am-9:07 am
1 stop5h 07m
Santa Ana J. Wayne/Orange Cnty
Wed 5/27
10:20 am-9:47 pm
2 stops9h 27m
$367
Kansas CitySanta Ana
MCI - SNA
MCISNA
Kansas City
Wed 7/1
7:25 pm-10:20 pm
1 stop4h 55m
Santa Ana J. Wayne/Orange Cnty
Wed 7/8
11:10 am-10:00 pm
2 stops8h 50m
$367
St. LouisSanta Ana
STL - SNA
STLSNA
Lambert-St Louis
Tue 6/9
3:57 pm-10:28 pm
1 stop8h 31m
Santa Ana J. Wayne/Orange Cnty
Tue 6/23
2:00 pm-11:56 pm
1 stop7h 56m
$387
SpringfieldSanta Ana
SGF - SNA
SGFSNA
Springfield-Branson
Sat 8/29
5:40 am-1:56 pm
2 stops10h 16m
Santa Ana J. Wayne/Orange Cnty
Tue 9/1
6:45 am-6:00 pm
1 stop9h 15m
$400
St. LouisSanta Ana
STL - SNA
STLSNA
Lambert-St Louis
Sat 5/23
5:00 pm-9:54 pm
1 stop6h 54m
Santa Ana J. Wayne/Orange Cnty
Sat 5/30
2:00 pm-11:59 pm
1 stop7h 59m
$409
Kansas CitySanta Ana
MCI - SNA
MCISNA
Kansas City
Tue 7/28
2:10 pm-6:20 pm
2 stops6h 10m
Santa Ana J. Wayne/Orange Cnty
Tue 8/4
1:00 pm-10:30 pm
1 stop7h 30m
$412
St. LouisSanta Ana
STL - SNA
STLSNA
Lambert-St Louis
Wed 6/10
8:35 am-2:55 pm
2 stops8h 20m
Santa Ana J. Wayne/Orange Cnty
Tue 6/16
7:00 am-5:45 pm
2 stops8h 45m
$442
ColumbiaSanta Ana
COU - SNA
COUSNA
Columbia Regional
Tue 5/12
9:00 am-1:18 pm
1 stop6h 18m
Santa Ana J. Wayne/Orange Cnty
Sun 5/24
10:37 am-9:59 pm
1 stop9h 22m
$453
Kansas CitySanta Ana
MCI - SNA
MCISNA
Kansas City
Fri 6/19
5:50 am-9:30 am
1 stop5h 40m
Santa Ana J. Wayne/Orange Cnty
Sun 6/21
12:25 pm-10:05 pm
1 stop7h 40m
$483
St. LouisSanta Ana
STL - SNA
STLSNA
Lambert-St Louis
Tue 6/16
2:28 pm-6:30 pm
1 stop6h 02m
Santa Ana J. Wayne/Orange Cnty
Mon 6/22
2:00 pm-11:56 pm
1 stop7h 56m
$488
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to Santa Ana
Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Missouri with our price prediction graph.
MCI-SNA
STL-SNA
SGF-SNA
COU-SNA
JLN-SNA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Santa Ana
USMO-SNA
MCI-SNA
STL-SNA
SGF-SNA
COU-SNA
How far ahead should I book a flight from Missouri to Santa Ana, California?
To ensure you get the cheapest price possible for a flight from Missouri to Santa Ana, California, you should look to book at least 82 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Missouri to Santa Ana, California?
Currently, August is the cheapest month in which you can book a flight from Missouri to Santa Ana, California (average of $88). Flying from Missouri to Santa Ana, California in April is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Missouri to Santa Ana, California?
Related info for your journey
Find useful and relevant information for your journey from Missouri to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santa Ana?
Book flights to Santa Ana if you plan to visit one of these locationsTustin
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Santa Ana flight routes
Top destinations
Alternative routes for Missouri to Santa Ana
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santa Ana by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Santa Ana by cabin class
Find flights from Missouri to Santa Ana, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and Santa Ana flights
Browse other Missouri and Santa Ana flight options. Last updated on April 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santa Ana
Explore flights to Santa Ana departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 29, 2026.
Missouri to Santa Ana flights
Consider these flights traveling from Missouri to Santa Ana.
Top 5 airlines flying from Missouri to Santa Ana
Discover the top 5 airlines that operate flights from Missouri to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$88 | Average$338 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$158 | Average$426 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$252 | Average$428 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$255 | Average$461 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$287 | Average$482 | FlexibilityNo cancel fee | On-time63% |