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$300+ Cheap flights from Santiago (SCL) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/24. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — SFO
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheapflights Tip: The best prices from Santiago Arturo Merino Benitez to San Francisco are usually found in March or October, booked 4 days in advance, depart on a Saturday or Thursday and return on a Wednesday

Cheap flight deals from Santiago to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2025.

Round-trip from

$572
(Copa Airlines)

One-way from

$300
(Kiwi.com)

Popular in

June

Cheapest in

March

Average price

$796
From Santiago Arturo Merino Benitez to San Francisco
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One-way flight from Santiago Arturo Merino Benitez to San Francisco
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Highest demand for flights based on searches. 9% potential increase in price ($73 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Santiago to San Francisco

Cheapest flights from Santiago to San Francisco
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This LATAM Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/3010:55 pmSCL - SFO
1 stop17h 05mLATAM Airlines
Wed 11/56:00 amSFO - SCL
2 stops20h 00mLATAM Airlines
Deal found 6/10$569
This Copa Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/95:10 amSCL - SFO
1 stop22h 30mCopa Airlines
Thu 10/21:28 amSFO - SCL
1 stop18h 12mCopa Airlines
Deal found 6/10$572
This Cheapflightsfares deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/512:45 amSCL - SFO
2 stops26h 10mAvianca
Thu 11/131:20 pmSFO - SCL
2 stops20h 00mAvianca
Deal found 6/12$575
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/811:05 pmSCL - SFO
1 stop16h 28mDelta
Fri 10/36:00 amSFO - SCL
2 stops20h 50mDelta
Deal found 6/11$579
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1710:45 pmSCL - SFO
1 stop30h 10mUnited Airlines
Sun 1/411:55 pmSFO - SCL
1 stop27h 55mUnited Airlines
Deal found 6/10$583
This LATAM Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1611:30 pmSCL - SFO
2 stops28h 29mMultiple Airlines
Sat 10/410:30 pmSFO - SCL
2 stops28h 20mMultiple Airlines
Deal found 6/9$594
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/299:50 pmSCL - SFO
1 stop28h 00mAmerican Airlines
Wed 10/2911:59 pmSFO - SCL
1 stop27h 51mAmerican Airlines
Deal found 6/11$639

Cheapflights Fare Finder

Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Santiago

Fly to

San Francisco

Route

Depart

Return

Price

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 9/9

5:10 am-11:40 pm

1 stop22h 30m

San Francisco

Thu 10/2

1:28 am-11:40 pm

1 stop18h 12m

$572

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 8/26

10:45 pm-11:33 am

1 stop15h 48m

San Francisco

Sat 9/6

7:15 am-6:00 am

1 stop19h 45m

$577

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 9/8

11:05 pm-11:33 am

1 stop16h 28m

San Francisco

Fri 10/3

6:00 am-6:50 am

2 stops20h 50m

$579

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 7/24

6:10 am-11:55 pm

2 stops20h 45m

San Francisco

Sat 8/2

2:30 am-4:15 am

2 stops22h 45m

$585

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 7/29

9:50 pm-10:50 pm

1 stop28h 00m

San Francisco

Wed 10/29

11:59 pm-7:50 am

1 stop27h 51m

$639

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 9/10

9:20 am-2:21 pm

1 stop33h 01m

San Francisco

Mon 9/29

6:00 am-7:00 am

1 stop21h 00m

$664

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 7/24

6:10 am-11:55 pm

2 stops20h 45m

$300

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Fri 7/25

4:10 am-11:40 pm

1 stop22h 30m

$324

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sun 7/27

10:45 pm-10:00 am

1 stop14h 15m

$427

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 7/10

10:55 pm-2:36 pm

1 stop18h 41m

$452

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Showing 1-10 of 12 results
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Best time to book a flight from Santiago to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to San Francisco

How far ahead should I book a flight from Santiago to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Santiago to San Francisco. Price data was last updated on June 9, 2025.

The price you pay for your flight from Santiago to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 4 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santiago to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $276). Flying from Santiago to San Francisco in June is currently the most expensive (average of $364). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SCL to SFO?

Find hourly flight availability from Santiago to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

It’s typically best to fly out from Santiago to San Francisco in the afternoon. Doing so could potentially save you 32% on the flight price compared to flying in the evening, which is usually more expensive.

Rainfall in San Francisco by month

Plan your trip to San Francisco by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

Temperature in San Francisco by month

Plan your trip to San Francisco by taking into account the average temperature totals by month.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated June 12, 2025.
Read through reviews of airlines operating flights from Santiago to San Francisco, such as Delta, LATAM Airlines and Copa Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,950 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,950 reviews
Delta
8.0
Very good
7,950 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
LATAM Airlines
7.5
Good
1,785 reviews
Delta
8.0
Very good
7,950 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Copa Airlines
7.5
Good
1,451 reviews
Delta
8.0
Very good
7,950 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,950 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Avianca
6.7
Okay
2,345 reviews
Delta
8.0
Very good
7,950 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Santiago to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Santiago to San Francisco round-trip?

    Currently priced at $572, Copa Airlines will fly you from Santiago to San Francisco and back. In addition to Copa Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from LATAM Airlines and Delta - these airlines can fly you to your destination from $577 and $579, respectively. Copa Airlines is priced at 15% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Santiago to San Francisco one-way?

    One-way options have recently been found by users for as low as $300 on Avianca. Other airlines that offer cheap prices include Copa Airlines from $324 and LATAM Airlines from $427 one-way.

  • Can I find deals for flights from Santiago to San Francisco that include hotel bookings?

    Yes. In addition to deals on Santiago to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to San Francisco.

  • Can I find deals for business class flights from Santiago to San Francisco?

    Yes. Cheapflights offers flight deals from Santiago to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $276). Flying from Santiago to San Francisco in June is currently the most expensive (average of $364). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santiago?

Book flights to Santiago if you plan to visit one of these locations
Roseville
Mountain View
South San Francisco
Livermore
Turlock
Santa Cruz
Manteca
Fairfield
Watsonville
Antioch
Hollister
Milpitas
Newark
Hayward
Alameda
Sunnyvale
Daly City
Union City
Campbell
Capitola

Browse thousands of different options on Cheapflights for your next trip

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Top 5 airlines flying from Santiago to San Francisco

Discover the top 5 airlines that operate flights from Santiago to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$513Average$838FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$518Average$633FlexibilityNo cancel feeOn-time70%
DeltaCheapest$533Average$722FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$542Average$709FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$612Average$884FlexibilityNo cancel feeOn-time71%

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