$318+ Cheap flights from Santiago (SCL) to San Francisco (SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/17. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — SFO
Jun 23 — Jun 301
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
Last-minute
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Cheapest flights from Santiago to San FranciscoExplore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 24, 2026.
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 24, 2026.
This FlightHub deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1112:40 am
SCL
- SFO
2 stops21h 59m
LATAM Airlines
Tue 8/186:50 am
SFO
- SCL
2 stops19h 45m
LATAM Airlines
Deal found 5/20![LATAM Airlines logo]()
$579
This eDestinos deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:40 pm
SCL
- SFO
1 stop16h 42m
LATAM Airlines
Wed 8/266:50 am
SFO
- SCL
2 stops21h 05m
LATAM Airlines
Deal found 5/20![LATAM Airlines logo]()
$604
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/412:40 am
SCL
- SFO
2 stops21h 59m
Delta
Tue 8/116:00 am
SFO
- SCL
2 stops20h 35m
Delta
Deal found 5/19![Delta logo]()
$616
This Avianca deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Fri 8/2811:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 5/20![Avianca logo]()
$623
This Avianca deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Thu 8/2011:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 5/23![Avianca logo]()
$624
This American Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/239:30 pm
SCL
- SFO
1 stop19h 33m
American Airlines
Wed 10/1412:12 pm
SFO
- SCL
1 stop15h 38m
American Airlines
Deal found 5/23![American Airlines logo]()
$626
This Avianca deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Sat 8/1511:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 5/22![Avianca logo]()
$627
This Avianca deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Fri 5/292:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 5/21![Avianca logo]()
$628
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/258:50 pm
SCL
- SFO
2 stops22h 12m
American Airlines
Mon 9/78:08 am
SFO
- SCL
2 stops19h 57m
American Airlines
Deal found 5/24![American Airlines logo]()
$630
This American Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:30 pm
SCL
- SFO
2 stops20h 57m
American Airlines
Tue 8/119:05 am
SFO
- SCL
2 stops18h 45m
American Airlines
Deal found 5/23![American Airlines logo]()
$631
Best flights from Santiago to San FranciscoDiscover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 24, 2026.
Discover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 24, 2026.
This Copa Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/44:09 am
SCL
- SFO
1 stop17h 05m
Copa Airlines
Sun 6/78:16 pm
SFO
- SCL
1 stop20h 07m
Copa Airlines
Deal found 5/21![Copa Airlines logo]()
$648
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:40 pm
SCL
- SFO
1 stop16h 30m
Delta
Wed 6/247:00 am
SFO
- SCL
2 stops19h 35m
Delta
Deal found 5/19![Delta logo]()
$651
This LATAM Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/148:30 am
SCL
- SFO
1 stop18h 00m
Multiple Airlines
Wed 10/144:15 pm
SFO
- SCL
1 stop33h 20m
Multiple Airlines
Deal found 5/22![Multiple Airlines logo]()
$694
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/311:25 pm
SCL
- SFO
1 stop14h 28m
Delta
Thu 6/259:20 am
SFO
- SCL
1 stop17h 15m
Delta
Deal found 5/19![Delta logo]()
$651
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/711:05 pm
SCL
- SFO
1 stop23h 55m
Delta
Mon 6/229:20 am
SFO
- SCL
1 stop17h 15m
Delta
Deal found 5/21![Delta logo]()
$651
This LATAM Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/49:30 pm
SCL
- SFO
2 stops27h 36m
Multiple Airlines
Mon 6/86:00 am
SFO
- SCL
2 stops28h 35m
Multiple Airlines
Deal found 5/21![Multiple Airlines logo]()
$720
This LATAM Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/69:30 pm
SCL
- SFO
2 stops29h 00m
Multiple Airlines
Mon 7/132:00 pm
SFO
- SCL
3 stops28h 45m
Multiple Airlines
Deal found 5/22![Multiple Airlines logo]()
$728
This LATAM Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1011:00 pm
SCL
- SFO
2 stops24h 17m
Multiple Airlines
Mon 7/203:05 pm
SFO
- SCL
1 stop36h 50m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$729
This Delta deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/278:40 pm
SCL
- SFO
1 stop21h 10m
Delta
Wed 11/117:30 am
SFO
- SCL
2 stops18h 20m
Delta
Deal found 5/23![Delta logo]()
$801
This Delta deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/248:40 pm
SCL
- SFO
1 stop25h 46m
Delta
Wed 11/116:00 am
SFO
- SCL
1 stop20h 40m
Delta
Deal found 5/23![Delta logo]()
$824
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/127:55 pm
SCL
- SFO
2 stops19h 00m
Delta
Thu 6/187:00 am
SFO
- SCL
1 stop19h 35m
Delta
Deal found 5/20![Delta logo]()
$841
Last-minute flights from Santiago to San FranciscoDiscover last-minute flight deals from Santiago to San Francisco. Data last updated May 24, 2026 and is based on user searches.
Discover last-minute flight deals from Santiago to San Francisco. Data last updated May 24, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Fri 5/292:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 5/21![Avianca logo]()
$628
This Avianca deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Thu 8/2011:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 5/23![Avianca logo]()
$624
This American Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/289:00 pm
SCL
- SFO
2 stops19h 04m
American Airlines
Thu 8/209:05 am
SFO
- SCL
1 stop18h 45m
American Airlines
Deal found 5/20![American Airlines logo]()
$634
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2810:55 pm
SCL
- SFO
1 stop26h 54m
Delta
Thu 8/207:00 am
SFO
- SCL
1 stop20h 25m
Delta
Deal found 5/20![Delta logo]()
$639
This Copa Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/44:09 am
SCL
- SFO
1 stop17h 05m
Copa Airlines
Sun 6/71:12 am
SFO
- SCL
1 stop18h 31m
Copa Airlines
Deal found 5/21![Copa Airlines logo]()
$648
This CheapOair deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/98:40 pm
SCL
- SFO
1 stop21h 10m
LATAM Airlines
Thu 6/259:20 am
SFO
- SCL
1 stop17h 15m
LATAM Airlines
Deal found 5/20![LATAM Airlines logo]()
$641
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/2911:05 pm
SCL
- SFO
1 stop23h 55m
Delta
Sun 7/126:00 am
SFO
- SCL
1 stop22h 15m
Delta
Deal found 5/20![Delta logo]()
$650
One-way flights from Santiago to San FranciscoSearch for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 24, 2026.
Search for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 24, 2026.
This Avianca deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Deal found 5/20![Avianca logo]()
$318
This Avianca deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:40 am
SCL
- SFO
2 stops20h 15m
Avianca
Deal found 5/24![Avianca logo]()
$319
This Avianca deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Deal found 5/20![Avianca logo]()
$329
This SmartFares deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/153:20 pm
SCL
- SFO
2 stops24h 30m
Avianca
Deal found 5/20![Avianca logo]()
$335
This FlightHub deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1512:30 am
SCL
- SFO
2 stops26h 25m
Avianca
Deal found 5/23![Avianca logo]()
$346
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:40 am
SCL
- SFO
3 stops26h 45m
Avianca
Deal found 5/23![Avianca logo]()
$350
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Deal found 5/23![Avianca logo]()
$351
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3112:30 am
SCL
- SFO
3 stops32h 55m
Avianca
Deal found 5/23![Avianca logo]()
$355
This Flightnetwork deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/912:30 am
SCL
- SFO
3 stops32h 55m
Avianca
Deal found 5/23![Avianca logo]()
$367
Find flight deals from Santiago to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $579 (FlightHub) |
One-way from | $318 (Avianca) |
Popular in | June |
Cheapest in | October |
Average price | $664 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 24, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Thu 6/4
4:09 am-6:14 pm
1 stop17h 05m
San Francisco
Sun 6/7
8:16 pm-7:23 pm
1 stop20h 07m
$648
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Fri 6/5
8:40 pm-10:10 am
1 stop16h 30m
San Francisco
Wed 6/24
7:00 am-5:35 am
2 stops19h 35m
$651
Quickest round-trip
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Wed 6/3
11:25 pm-10:53 am
1 stop14h 28m
San Francisco
Thu 6/25
9:20 am-5:35 am
1 stop17h 15m
$651
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Sun 6/7
11:05 pm-8:00 pm
1 stop23h 55m
San Francisco
Mon 6/22
9:20 am-5:35 am
1 stop17h 15m
$651
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Tue 7/14
8:30 am-11:30 pm
1 stop18h 00m
San Francisco
Wed 10/14
4:15 pm-5:35 am
1 stop33h 20m
$694
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Thu 6/4
9:30 pm-10:06 pm
2 stops27h 36m
San Francisco
Mon 6/8
6:00 am-1:35 pm
2 stops28h 35m
$720
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Mon 7/6
9:30 pm-11:30 pm
2 stops29h 00m
San Francisco
Mon 7/13
2:00 pm-9:45 pm
3 stops28h 45m
$728
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Wed 6/10
11:00 pm-8:17 pm
2 stops24h 17m
San Francisco
Mon 7/20
3:05 pm-6:55 am
1 stop36h 50m
$729
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Mon 7/27
8:40 pm-2:50 pm
1 stop21h 10m
San Francisco
Wed 11/11
7:30 am-6:50 am
2 stops18h 20m
$801
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Fri 7/24
8:40 pm-7:26 pm
1 stop25h 46m
San Francisco
Wed 11/11
6:00 am-7:40 am
1 stop20h 40m
$824
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Santiago to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to San Francisco in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Santiago-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santiago-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santiago to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.
SCL-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santiago to San Francisco
How far ahead should I book a flight from Santiago to San Francisco?
The price you pay for your flight from Santiago to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 69 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Santiago to San Francisco?
Currently, October is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $554). Flying from Santiago to San Francisco in June is currently the most expensive (average of $796). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Santiago to San Francisco?
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated May 24, 2026.
Peruse reviews from past customers who have flown with Delta,Copa Airlines, andLATAM Airlines from Santiago to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Overall
7.9
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Overall
7.9
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Overall
7.9
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Overall
7.9
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Overall
7.9
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Overall
7.9
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Santiago to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
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Santiago and San Francisco flights
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Top 6 airlines flying from Santiago to San Francisco
Discover the top 6 airlines that operate flights from Santiago to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$433 | Average$640 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$481 | Average$698 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$504 | Average$663 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$511 | Average$747 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$554 | Average$735 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$571 | Average$710 | FlexibilityNo cancel fee | On-time69% |