$290+ Cheap flights from Santiago (SCL) to San Francisco (SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/16. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — SFO
Mar 29 — Apr 51
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Santiago to San FranciscoExplore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 27, 2026.
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 27, 2026.
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:35 pm
SCL
- SFO
1 stop27h 21m
American Airlines
Tue 5/126:15 am
SFO
- SCL
1 stop21h 50m
American Airlines
Deal found 2/26![American Airlines logo]()
$519
This LATAM Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1910:30 am
SCL
- SFO
2 stops32h 26m
LATAM Airlines
Tue 5/2611:59 pm
SFO
- SCL
2 stops34h 36m
LATAM Airlines
Deal found 2/25![LATAM Airlines logo]()
$521
This Avianca deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:40 am
SCL
- SFO
2 stops20h 15m
Avianca
Mon 5/42:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 2/23![Avianca logo]()
$522
This Copa Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/224:49 am
SCL
- SFO
1 stop16h 36m
Copa Airlines
Sun 4/261:23 am
SFO
- SCL
1 stop19h 03m
Copa Airlines
Deal found 2/24![Copa Airlines logo]()
$523
This LATAM Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/810:30 am
SCL
- SFO
2 stops26h 40m
LATAM Airlines
Wed 5/138:30 am
SFO
- SCL
2 stops18h 05m
LATAM Airlines
Deal found 2/26![LATAM Airlines logo]()
$524
This LATAM Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:15 am
SCL
- SFO
1 stop18h 45m
LATAM Airlines
Thu 4/2312:06 pm
SFO
- SCL
1 stop16h 09m
LATAM Airlines
Deal found 2/25![LATAM Airlines logo]()
$525
This Delta deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2210:55 pm
SCL
- SFO
1 stop25h 28m
Delta
Mon 4/277:25 am
SFO
- SCL
2 stops20h 50m
Delta
Deal found 2/24![Delta logo]()
$526
This Delta deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/218:40 pm
SCL
- SFO
2 stops27h 43m
Delta
Thu 5/2811:55 pm
SFO
- SCL
2 stops28h 20m
Delta
Deal found 2/23![Delta logo]()
$527
This LATAM Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/154:50 pm
SCL
- SFO
2 stops29h 19m
LATAM Airlines
Thu 5/146:00 am
SFO
- SCL
2 stops28h 35m
LATAM Airlines
Deal found 2/23![LATAM Airlines logo]()
$534
This LATAM Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2211:05 pm
SCL
- SFO
2 stops27h 50m
LATAM Airlines
Mon 4/276:00 am
SFO
- SCL
1 stop22h 15m
LATAM Airlines
Deal found 2/23![LATAM Airlines logo]()
$535
This LATAM Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:30 pm
SCL
- SFO
2 stops35h 05m
LATAM Airlines
Wed 4/811:35 pm
SFO
- SCL
2 stops27h 25m
LATAM Airlines
Deal found 2/25![LATAM Airlines logo]()
$536
Best flights from Santiago to San FranciscoDiscover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 27, 2026.
Discover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 27, 2026.
This Delta deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:40 pm
SCL
- SFO
1 stop26h 44m
Delta
Thu 5/2811:55 pm
SFO
- SCL
2 stops28h 20m
Delta
Deal found 2/23![Delta logo]()
$527
This Copa Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2311:25 am
SCL
- SFO
1 stop15h 15m
Copa Airlines
Thu 4/308:37 pm
SFO
- SCL
1 stop19h 46m
Copa Airlines
Deal found 2/26![Copa Airlines logo]()
$613
This Avianca deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/307:40 am
SCL
- SFO
2 stops44h 15m
Avianca
Mon 4/611:55 pm
SFO
- SCL
2 stops25h 50m
Avianca
Deal found 2/24![Avianca logo]()
$674
This United Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2112:46 am
SCL
- SFO
2 stops19h 27m
United Airlines
Mon 4/2711:59 pm
SFO
- SCL
2 stops23h 21m
United Airlines
Deal found 2/26![United Airlines logo]()
$694
This Copa Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2111:25 am
SCL
- SFO
1 stop15h 15m
Copa Airlines
Sun 5/31:12 am
SFO
- SCL
1 stop19h 14m
Copa Airlines
Deal found 2/23![Copa Airlines logo]()
$633
This Delta deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:40 pm
SCL
- SFO
1 stop26h 48m
Delta
Mon 4/139:20 am
SFO
- SCL
1 stop18h 05m
Delta
Deal found 2/23![Delta logo]()
$706
This Copa Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/313:30 am
SCL
- SFO
1 stop18h 55m
Copa Airlines
Thu 4/238:37 pm
SFO
- SCL
1 stop23h 49m
Copa Airlines
Deal found 2/26![Copa Airlines logo]()
$653
This Copa Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/84:17 am
SCL
- SFO
1 stop17h 08m
Copa Airlines
Thu 5/71:12 am
SFO
- SCL
1 stop15h 11m
Copa Airlines
Deal found 2/26![Copa Airlines logo]()
$673
This Copa Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/25:17 am
SCL
- SFO
1 stop17h 08m
Copa Airlines
Thu 4/308:37 pm
SFO
- SCL
1 stop23h 06m
Copa Airlines
Deal found 2/26![Copa Airlines logo]()
$673
This Copa Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/251:38 am
SCL
- SFO
1 stop26h 02m
Copa Airlines
Tue 4/71:23 am
SFO
- SCL
1 stop22h 37m
Copa Airlines
Deal found 2/26![Copa Airlines logo]()
$743
Last-minute flights from Santiago to San FranciscoDiscover last-minute flight deals from Santiago to San Francisco. Data last updated February 27, 2026 and is based on user searches.
Discover last-minute flight deals from Santiago to San Francisco. Data last updated February 27, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/77:25 am
SCL
- SFO
2 stops20h 55m
Avianca
Fri 4/172:15 pm
SFO
- SCL
2 stops30h 05m
Avianca
Deal found 2/23![Avianca logo]()
$631
This SmartFares deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/84:25 pm
SCL
- SFO
2 stops24h 35m
Avianca
Sun 3/292:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 2/24![Avianca logo]()
$633
This Justfly.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/97:25 am
SCL
- SFO
2 stops33h 35m
Avianca
Fri 4/172:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 2/23![Avianca logo]()
$602
This Avianca deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/107:25 am
SCL
- SFO
2 stops20h 15m
Avianca
Fri 4/172:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 2/23![Avianca logo]()
$559
This Avianca deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/107:25 am
SCL
- SFO
2 stops20h 15m
Avianca
Thu 4/232:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 2/24![Avianca logo]()
$560
This Avianca deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/107:25 am
SCL
- SFO
2 stops20h 15m
Avianca
Fri 6/511:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 2/25![Avianca logo]()
$623
This Avianca deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/177:25 am
SCL
- SFO
2 stops20h 15m
Avianca
Wed 3/252:20 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 2/23![Avianca logo]()
$564
This Avianca deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/177:25 am
SCL
- SFO
2 stops20h 15m
Avianca
Thu 4/22:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 2/25![Avianca logo]()
$586
This Avianca deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/247:25 am
SCL
- SFO
2 stops20h 15m
Avianca
Sun 4/511:55 pm
SFO
- SCL
2 stops25h 50m
Avianca
Deal found 2/24![Avianca logo]()
$657
This SmartFares deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/251:35 am
SCL
- SFO
2 stops25h 15m
Avianca
Tue 4/72:30 am
SFO
- SCL
2 stops23h 15m
Avianca
Deal found 2/26![Avianca logo]()
$632
This Avianca deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/251:35 am
SCL
- SFO
2 stops25h 15m
Avianca
Wed 4/111:55 pm
SFO
- SCL
2 stops25h 50m
Avianca
Deal found 2/24![Avianca logo]()
$672
This Avianca deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/307:40 am
SCL
- SFO
2 stops44h 15m
Avianca
Mon 4/611:55 pm
SFO
- SCL
2 stops25h 50m
Avianca
Deal found 2/24![Avianca logo]()
$674
One-way flights from Santiago to San FranciscoSearch for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated February 27, 2026.
Search for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated February 27, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:40 am
SCL
- SFO
2 stops20h 15m
Avianca
Deal found 2/23![Avianca logo]()
$290
This SmartFares deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/14:20 pm
SCL
- SFO
2 stops35h 35m
Avianca
Deal found 2/24![Avianca logo]()
$296
This Avianca deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/107:25 am
SCL
- SFO
2 stops20h 15m
Avianca
Deal found 2/23![Avianca logo]()
$302
This Avianca deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/77:25 am
SCL
- SFO
2 stops20h 55m
Avianca
Deal found 2/25![Avianca logo]()
$303
This Cheapflightsfares deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/153:20 pm
SCL
- SFO
2 stops35h 35m
Avianca
Deal found 2/23![Avianca logo]()
$308
This SmartFares deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/273:20 pm
SCL
- SFO
2 stops35h 35m
Avianca
Deal found 2/23![Avianca logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:25 am
SCL
- SFO
2 stops19h 25m
Avianca
Deal found 2/23![Avianca logo]()
$317
This Justfly.com deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/84:25 pm
SCL
- SFO
2 stops24h 35m
Avianca
Deal found 2/25![Avianca logo]()
$328
Find flight deals from Santiago to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 27, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $519 (LATAM Airlines) |
One-way from | $290 (Kiwi.com) |
Popular in | June |
Cheapest in | October |
Average price | $571 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 27, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Thu 4/23
8:40 pm-8:24 pm
1 stop26h 44m
San Francisco
Thu 5/28
11:55 pm-7:15 am
2 stops28h 20m
$527
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Thu 4/23
11:25 am-11:40 pm
1 stop15h 15m
San Francisco
Thu 4/30
8:37 pm-7:23 pm
1 stop19h 46m
$613
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Tue 4/21
11:25 am-11:40 pm
1 stop15h 15m
San Francisco
Sun 5/3
1:12 am-11:26 pm
1 stop19h 14m
$633
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Tue 3/31
3:30 am-6:25 pm
1 stop18h 55m
San Francisco
Thu 4/23
8:37 pm-11:26 pm
1 stop23h 49m
$653
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Wed 4/8
4:17 am-6:25 pm
1 stop17h 08m
San Francisco
Thu 5/7
1:12 am-7:23 pm
1 stop15h 11m
$673
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Thu 4/2
5:17 am-6:25 pm
1 stop17h 08m
San Francisco
Thu 4/30
8:37 pm-10:43 pm
1 stop23h 06m
$673
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Mon 3/30
7:40 am-11:55 pm
2 stops44h 15m
San Francisco
Mon 4/6
11:55 pm-4:45 am
2 stops25h 50m
$674
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Tue 4/21
12:46 am-5:13 pm
2 stops19h 27m
San Francisco
Mon 4/27
11:59 pm-2:20 am
2 stops23h 21m
$694
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Mon 4/6
8:40 pm-8:28 pm
1 stop26h 48m
San Francisco
Mon 4/13
9:20 am-6:25 am
1 stop18h 05m
$706
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Wed 3/25
1:38 am-11:40 pm
1 stop26h 02m
San Francisco
Tue 4/7
1:23 am-3:00 am
1 stop22h 37m
$743
Showing 1-10 of 22 resultsSorted by cheapest first
Compare providers for flights from Santiago to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to San Francisco in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*2 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Santiago-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santiago-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santiago to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.
SCL-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santiago to San Francisco
How far ahead should I book a flight from Santiago to San Francisco?
Use this chart to determine the optimal time to book a round-trip flight from Santiago to San Francisco. Price data was last updated on February 20, 2026.
The price you pay for your flight from Santiago to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 45 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Santiago to San Francisco?
Currently, October is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $465). Flying from Santiago to San Francisco in July is currently the most expensive (average of $554). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated February 27, 2026.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and Copa Airlines from Santiago to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Food
7.2
Comfort
7.9
Crew
8.5
Boarding
8.1
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Food
7.2
Comfort
7.9
Crew
8.5
Boarding
8.1
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Food
7.2
Comfort
7.9
Crew
8.5
Boarding
8.1
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Food
7.2
Comfort
7.9
Crew
8.5
Boarding
8.1
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Food
7.2
Comfort
7.9
Crew
8.5
Boarding
8.1
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Food
7.2
Comfort
7.9
Crew
8.5
Boarding
8.1
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Santiago to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Livermore
Roseville
Watsonville
San Bruno
Daly City
Sunnyvale
Vacaville
Turlock
San Carlos
San Ramon
Redwood City
Rancho Cordova
San Lorenzo
Davis
Hollister
Manteca
Union City
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Santiago and San Francisco flights
Browse other Santiago and San Francisco flight options. Last updated on February 27, 2026.
Other flights from Santiago
Browse through other flights departing from Santiago. Flights are based on user searches made on Cheapflights and were last updated on February 27, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 27, 2026.
Top 6 airlines flying from Santiago to San Francisco
Discover the top 6 airlines that operate flights from Santiago to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$433 | Average$675 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$481 | Average$613 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$508 | Average$701 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$511 | Average$627 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$554 | Average$774 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$571 | Average$710 | FlexibilityNo cancel fee | On-time69% |