How long is the flight from Santiago to San Francisco?

Departing from Santiago to San Francisco will take you 23h 05m. The distance from Santiago to San Francisco is about 5918 mi.

What are the cheapest airlines flying from Santiago to San Francisco round-trip?

Currently priced at $433, Avianca will fly you from Santiago to San Francisco and back. In addition to Avianca, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Copa Airlines and United Airlines - these airlines can fly you to your destination from $520 and $532, respectively. Avianca is priced at 36% lower than the current average price of a flight leaving 3 months from now.

What is the cheapest day to fly from Santiago to San Francisco?

Travelers seeking maximum savings on their Santiago to San Francisco flight should consider departing on Sunday afternoons when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What are the most popular airlines that fly from Santiago to San Francisco?

When booking a flight from Santiago to San Francisco, you may want to consider flying on American Airlines, Avianca or Copa Airlines as they are the most popular for this route.

Can I find deals for flights from Santiago to San Francisco that include hotel bookings?

Yes. In addition to deals on Santiago to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Santiago to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to San Francisco.

Can I find deals for business class flights from Santiago to San Francisco?

Yes. Cheapflights offers flight deals from Santiago to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$280+ Flights from Santiago to San Francisco

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Cheapflights Tip: The best prices from Santiago Arturo Merino Benitez to San Francisco are usually found in September or August, booked 76 days in advance, depart on a Saturday or Thursday and return on a Wednesday

Cheap flight deals from Santiago to San Francisco

Round-trip from	$507 (Priceline)
One-way from	$280 (Cheapflightsfares)
Popular in	January
Cheapest in	September
Average price	$579

From Santiago Arturo Merino Benitez to San Francisco

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One-way flight from Santiago Arturo Merino Benitez to San Francisco

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Highest demand for flights based on searches. 12% potential increase in price ($94 potential increase over avg. RT price).

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Cheapest flight prices on average. 3% potential price decrease ($21 potential savings vs. average RT price).

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Average for round-trip flights in September 2025

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Find flight deals from Santiago to San Francisco

Cheapest flights from Santiago to San Francisco
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

Thu 11/64:25 pmSCL - SFO

2 stops24h 35mAvianca

Tue 11/111:35 amSFO - SCL

2 stops22h 55mAvianca

Deal found 9/16

$507

Thu 11/65:12 amSCL - SFO

1 stop23h 05mCopa Airlines

Sat 11/1512:36 amSFO - SCL

1 stop18h 05mCopa Airlines

Deal found 9/16

$512

Tue 10/141:13 amSCL - SFO

1 stop26h 26mCopa Airlines

Sun 10/261:36 amSFO - SCL

1 stop14h 44mCopa Airlines

Deal found 9/16

$513

Thu 10/309:15 pmSCL - SFO

1 stop25h 43mAmerican Airlines

Thu 11/68:00 amSFO - SCL

1 stop18h 55mAmerican Airlines

Deal found 9/15

$523

Mon 11/1011:15 pmSCL - SFO

1 stop20h 48mAmerican Airlines

Mon 1/126:10 amSFO - SCL

1 stop20h 40mAmerican Airlines

Deal found 9/15

$525

Thu 9/259:55 pmSCL - SFO

1 stop19h 10mAmerican Airlines

Wed 10/811:59 pmSFO - SCL

1 stop28h 01mAmerican Airlines

Deal found 9/16

$526

Thu 9/259:55 pmSCL - SFO

1 stop19h 10mAmerican Airlines

Tue 10/78:08 amSFO - SCL

2 stops19h 52mAmerican Airlines

Deal found 9/15

$531

Best flights from Santiago to San Francisco
Discover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2025.

Fri 11/75:12 amSCL - SFO

1 stop23h 05mCopa Airlines

Mon 11/1712:36 amSFO - SCL

1 stop22h 07mCopa Airlines

Deal found 9/15

$512

Thu 11/610:25 pmSCL - SFO

1 stop17h 42mAmerican Airlines

Sun 11/1611:59 pmSFO - SCL

1 stop26h 56mAmerican Airlines

Deal found 9/17

$526

Mon 9/299:40 pmSCL - SFO

1 stop23h 52mDelta

Wed 10/157:15 amSFO - SCL

2 stops18h 45mDelta

Deal found 9/17

$535

Thu 1/2910:45 pmSCL - SFO

1 stop18h 35mUnited Airlines

Tue 3/35:00 amSFO - SCL

1 stop22h 50mUnited Airlines

Deal found 9/15

$544

Wed 11/53:23 amSCL - SFO

1 stop24h 54mCopa Airlines

Sat 11/1512:36 amSFO - SCL

1 stop18h 05mCopa Airlines

Deal found 9/17

$512

Mon 12/1511:10 pmSCL - SFO

1 stop26h 49mDelta

Mon 12/296:00 amSFO - SCL

2 stops18h 35mDelta

Deal found 9/15

$535

Fri 11/75:12 amSCL - SFO

1 stop23h 05mCopa Airlines

Sun 11/1612:36 amSFO - SCL

1 stop18h 05mCopa Airlines

Deal found 9/15

$512

Tue 3/311:25 pmSCL - SFO

2 stops23h 00mDelta

Tue 3/319:00 amSFO - SCL

1 stop19h 00mDelta

Deal found 9/16

$545

Tue 10/143:35 amSCL - SFO

1 stop24h 04mCopa Airlines

Sun 10/261:36 amSFO - SCL

1 stop14h 44mCopa Airlines

Deal found 9/15

$532

Last-minute flights from Santiago to San Francisco
Discover last-minute flight deals from Santiago to San Francisco. Data last updated September 17, 2025 and is based on user searches.

Thu 9/259:55 pmSCL - SFO

1 stop19h 10mAmerican Airlines

Wed 10/812:27 pmSFO - SCL

1 stop15h 33mAmerican Airlines

Deal found 9/15

$525

Thu 9/259:55 pmSCL - SFO

1 stop19h 10mAmerican Airlines

Tue 10/78:08 amSFO - SCL

2 stops19h 52mAmerican Airlines

Deal found 9/15

$531

Thu 9/259:40 pmSCL - SFO

1 stop18h 15mDelta

Wed 10/86:10 amSFO - SCL

2 stops20h 40mDelta

Deal found 9/15

$535

Mon 9/297:10 amSCL - SFO

2 stops19h 35mAvianca

Tue 10/1412:05 amSFO - SCL

2 stops19h 25mAvianca

Deal found 9/15

$534

Mon 9/299:55 pmSCL - SFO

2 stops21h 14mAmerican Airlines

Wed 10/159:00 amSFO - SCL

2 stops19h 00mAmerican Airlines

Deal found 9/16

$536

Tue 10/141:13 amSCL - SFO

1 stop26h 26mCopa Airlines

Sun 10/261:36 amSFO - SCL

1 stop14h 44mCopa Airlines

Deal found 9/16

$513

Thu 10/3011:55 pmSCL - SFO

1 stop18h 38mLATAM Airlines

Thu 11/68:20 amSFO - SCL

1 stop16h 40mLATAM Airlines

Deal found 9/15

$523

Thu 10/309:15 pmSCL - SFO

2 stops21h 26mAmerican Airlines

Thu 11/67:10 amSFO - SCL

2 stops19h 45mAmerican Airlines

Deal found 9/15

$527

One-way flights from Santiago to San Francisco
Search for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 17, 2025.

Wed 11/51:35 amSCL - SFO

2 stops26h 45mAvianca

Deal found 9/15

$280

Mon 9/223:30 pmSCL - SFO

2 stops35h 15mAvianca

Deal found 9/16

$290

Mon 10/63:30 pmSCL - SFO

2 stops25h 05mAvianca

Deal found 9/16

$293

Mon 10/203:30 pmSCL - SFO

2 stops25h 05mAvianca

Deal found 9/15

$296

Tue 9/233:30 pmSCL - SFO

2 stops25h 05mAvianca

Deal found 9/15

$297

Sun 11/97:25 amSCL - SFO

2 stops43h 25mAvianca

Deal found 9/16

$313

Wed 9/2412:55 amSCL - SFO

2 stops49h 50mAvianca

Deal found 9/15

$323

Mon 11/104:25 pmSCL - SFO

2 stops48h 35mAvianca

Deal found 9/16

$330

Fri 12/124:25 pmSCL - SFO

2 stops35h 55mAvianca

Deal found 9/15

$343

Mon 2/24:25 pmSCL - SFO

2 stops35h 55mAvianca

Deal found 9/16

$348

Sun 11/97:25 amSCL - SFO

3 stops41h 45mMultiple Airlines

Deal found 9/16

$360

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Fri 11/7

5:12 am-11:17 pm

1 stop23h 05m

San Francisco

Mon 11/17

12:36 am-3:43 am

1 stop22h 07m

$512

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 11/5

3:23 am-11:17 pm

1 stop24h 54m

San Francisco

Sat 11/15

12:36 am-11:41 pm

1 stop18h 05m

$512

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Fri 11/7

5:12 am-11:17 pm

1 stop23h 05m

San Francisco

Sun 11/16

12:36 am-11:41 pm

1 stop18h 05m

$512

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 11/6

10:25 pm-11:07 am

1 stop17h 42m

San Francisco

Sun 11/16

11:59 pm-7:55 am

1 stop26h 56m

$526

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 10/14

3:35 am-11:39 pm

1 stop24h 04m

San Francisco

Sun 10/26

1:36 am-8:20 pm

1 stop14h 44m

$532

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 9/29

9:40 pm-5:32 pm

1 stop23h 52m

San Francisco

Wed 10/15

7:15 am-6:00 am

2 stops18h 45m

$535

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 12/15

11:10 pm-8:59 pm

1 stop26h 49m

San Francisco

Mon 12/29

6:00 am-5:35 am

2 stops18h 35m

$535

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 1/29

10:45 pm-12:20 pm

1 stop18h 35m

San Francisco

Tue 3/3

5:00 am-8:50 am

1 stop22h 50m

$544

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 3/3

11:25 pm-5:25 pm

2 stops23h 00m

San Francisco

Tue 3/31

9:00 am-8:00 am

1 stop19h 00m

$545

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Sat 10/11

7:10 am-11:55 pm

2 stops20h 45m

$280

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 18 results

Best time to book a flight from Santiago to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to San Francisco

How far ahead should I book a flight from Santiago to San Francisco?

The price you pay for your flight from Santiago to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 76 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santiago to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $276). Flying from Santiago to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SCL to SFO?

It’s typically best to fly out from Santiago to San Francisco in the afternoon. Doing so could potentially save you 32% on the flight price compared to flying in the evening, which is usually more expensive.

Reviews of airlines servicing San Francisco

Peruse reviews from past customers who have flown with Delta, Copa Airlines, and LATAM Airlines from Santiago to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,961 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta

8.0

Very good

7,961 reviews

Delta

8.0

Very good

7,961 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Copa Airlines

7.6

Good

1,533 reviews

Delta

8.0

Very good

7,961 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

LATAM Airlines

7.5

Good

1,849 reviews

Delta

8.0

Very good

7,961 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines

7.4

Good

8,926 reviews

Delta

8.0

Very good

7,961 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,961 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

How long is the flight from Santiago to San Francisco?
Departing from Santiago to San Francisco will take you 23h 05m. The distance from Santiago to San Francisco is about 5918 mi.
What are the cheapest airlines flying from Santiago to San Francisco round-trip?
Currently priced at $433, Avianca will fly you from Santiago to San Francisco and back. In addition to Avianca, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Copa Airlines and United Airlines - these airlines can fly you to your destination from $520 and $532, respectively. Avianca is priced at 36% lower than the current average price of a flight leaving 3 months from now.
Can I find deals for flights from Santiago to San Francisco that include hotel bookings?
Yes. In addition to deals on Santiago to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santiago to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to San Francisco.
Can I find deals for business class flights from Santiago to San Francisco?
Yes. Cheapflights offers flight deals from Santiago to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Santiago to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $276). Flying from Santiago to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Roseville

Santa Cruz

Livermore

South San Francisco

Turlock

Antioch

Watsonville

Santa Clara

Manteca

Sunnyvale

Hollister

Vacaville

Foster City

Union City

Vallejo

Burlingame

Redwood City

San Mateo

San Leandro

Lathrop

Browse thousands of different options on Cheapflights for your next trip

Top 6 airlines flying from Santiago to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$433	Average$742	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$520	Average$626	FlexibilityNo cancel fee	On-time70%
United Airlines	Cheapest$532	Average$872	FlexibilityNo cancel fee	On-time69%
LATAM Airlines	Cheapest$542	Average$704	FlexibilityNo cancel fee	On-time81%
Delta	Cheapest$551	Average$723	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$612	Average$891	FlexibilityNo cancel fee	On-time71%

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$280+ Cheap flights from Santiago (SCL) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/11. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santiago to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Santiago Arturo Merino Benitez to San Francisco are usually found in September or August, booked 76 days in advance, depart on a Saturday or Thursday and return on a Wednesday

Cheap flight deals from Santiago to San Francisco

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Santiago to San Francisco

Cheapest flights from Santiago to San FranciscoExplore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Best time to book a flight from Santiago to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Santiago to San Francisco

How far ahead should I book a flight from Santiago to San Francisco?

What is the cheapest month to book a flight from Santiago to San Francisco?

What is the cheapest time of day to fly from SCL to SFO?

Reviews of airlines servicing San Francisco

Peruse reviews from past customers who have flown with Delta, Copa Airlines, and LATAM Airlines from Santiago to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Santiago to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Santiago to San Francisco?

What are the cheapest airlines flying from Santiago to San Francisco round-trip?

Can I find deals for flights from Santiago to San Francisco that include hotel bookings?

How can I find direct flights from Santiago to San Francisco?

Can I find deals for business class flights from Santiago to San Francisco?

What is the cheapest month to book a flight from Santiago to San Francisco?

Traveling to a place near San Francisco?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Santiago to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top 6 airlines flying from Santiago to San Francisco

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Cheapest flights from Santiago to San Francisco
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.