$397+ Cheap flights from Santiago (SCL) to San Francisco (SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/28. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — SFO
Oct 28 — Nov 41
Round-trip
1 adult, Economy
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Find cheap flights from Santiago to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santiago to San Francisco
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Best
Last-minute
One-way
Cheapest flights from Santiago to San FranciscoExplore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 28, 2026.
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 28, 2026.
This Avianca deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:30 am -
2 stops19h 10m
Mon 1/181:15 pm -
2 stops20h 55m
Deal found 9/24![Avianca logo]()
$764
This Avianca deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:30 am -
2 stops19h 10m
Sat 12/51:15 pm -
2 stops20h 55m
Deal found 9/27![Avianca logo]()
$765
This Avianca deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:30 am -
2 stops20h 25m
Thu 12/31:15 pm -
2 stops20h 55m
Deal found 9/28![Avianca logo]()
$766
This Avianca deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:30 am -
2 stops19h 10m
Tue 11/311:00 pm -
2 stops21h 05m
Deal found 9/24![Avianca logo]()
$772
This Avianca deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:40 am -
2 stops20h 15m
Wed 10/711:55 pm -
2 stops20h 25m
Deal found 9/25![Avianca logo]()
$777
This Avianca deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:40 am -
2 stops18h 55m
Tue 10/2011:55 pm -
2 stops20h 25m
Deal found 9/24![Avianca logo]()
$779
This Avianca deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:40 am -
2 stops18h 55m
Wed 10/711:55 pm -
2 stops20h 25m
Deal found 9/25![Avianca logo]()
$783
This Avianca deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:30 am -
2 stops20h 25m
Tue 12/11:15 pm -
2 stops20h 55m
Deal found 9/24![Avianca logo]()
$784
This Avianca deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:40 am -
2 stops18h 55m
Fri 10/2311:55 pm -
2 stops20h 25m
Deal found 9/26![Avianca logo]()
$785
This Avianca deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:40 am -
2 stops18h 55m
Wed 10/711:55 pm -
2 stops20h 25m
Deal found 9/25![Avianca logo]()
$789
Best flights from Santiago to San FranciscoDiscover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 28, 2026.
Discover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 28, 2026.
This Avianca deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:30 am -
2 stops19h 10m
Fri 11/271:15 pm -
2 stops20h 55m
Deal found 9/25![Avianca logo]()
$783
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2110:45 pm -
1 stop31h 13m
Mon 1/45:00 am -
1 stop22h 50m
Deal found 9/24![United Airlines logo]()
$823
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/179:50 pm -
1 stop17h 45m
Wed 1/137:00 am -
1 stop18h 55m
Deal found 9/25![Delta logo]()
$830
This Copa Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1612:15 pm -
1 stop34h 10m
Sun 11/227:36 pm -
1 stop23h 00m
Deal found 9/26![Copa Airlines logo]()
$833
This Avianca deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:30 am -
2 stops19h 10m
Sat 12/51:15 pm -
2 stops20h 55m
Deal found 9/28![Avianca logo]()
$785
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2110:45 pm -
1 stop31h 13m
Tue 12/2911:59 pm -
1 stop27h 51m
Deal found 9/25![United Airlines logo]()
$829
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/611:55 pm -
1 stop15h 59m
Tue 3/211:30 am -
2 stops22h 30m
Deal found 9/23![Delta logo]()
$836
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:25 pm -
2 stops19h 10m
Tue 2/167:00 am -
2 stops19h 40m
Deal found 9/26![Delta logo]()
$836
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/159:50 pm -
1 stop17h 45m
Tue 1/56:00 am -
1 stop20h 40m
Deal found 9/25![Delta logo]()
$836
Last-minute flights from Santiago to San FranciscoDiscover last-minute flight deals from Santiago to San Francisco. Data last updated September 28, 2026 and is based on user searches.
Discover last-minute flight deals from Santiago to San Francisco. Data last updated September 28, 2026 and is based on user searches.
This Mytrip deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/21:30 am -
2 stops26h 25m
Sat 10/102:15 pm -
2 stops35h 30m
Deal found 9/28![Avianca logo]()
$858
This Avianca deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:40 am -
2 stops18h 55m
Fri 10/232:15 pm -
2 stops21h 00m
Deal found 9/25![Avianca logo]()
$777
This Avianca deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:40 am -
2 stops18h 55m
Wed 10/711:55 pm -
2 stops20h 25m
Deal found 9/25![Avianca logo]()
$783
This Avianca deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:40 am -
2 stops18h 55m
Tue 1/51:15 pm -
2 stops20h 55m
Deal found 9/25![Avianca logo]()
$764
This Avianca deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:40 am -
2 stops18h 55m
Tue 10/2011:55 pm -
2 stops20h 25m
Deal found 9/24![Avianca logo]()
$779
This Avianca deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:40 am -
2 stops18h 55m
Wed 10/1411:55 pm -
2 stops20h 25m
Deal found 9/24![Avianca logo]()
$854
This SmartFares deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:20 pm -
2 stops35h 35m
Sat 10/1011:55 pm -
2 stops20h 25m
Deal found 9/23![Avianca logo]()
$800
This Justfly.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:20 pm -
2 stops34h 15m
Wed 10/142:15 pm -
2 stops35h 30m
Deal found 9/27![Avianca logo]()
$835
One-way flights from Santiago to San FranciscoSearch for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 28, 2026.
Search for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 28, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:22 am -
2 stops35h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Multiple Airlines logo]()
$397
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:07 am -
2 stops20h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Multiple Airlines logo]()
$420
This Avianca deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:30 am -
2 stops19h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Avianca logo]()
$460
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/55:22 am -
2 stops35h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Multiple Airlines logo]()
$464
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/12:13 am -
3 stops47h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Multiple Airlines logo]()
$467
This SmartFares deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/254:15 pm -
2 stops24h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Avianca logo]()
$469
This SmartFares deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/104:15 pm -
2 stops24h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Avianca logo]()
$474
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:40 am -
2 stops18h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Avianca logo]()
$478
This SmartFares deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/117:30 am -
2 stops33h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Avianca logo]()
$483
Find flight deals from Santiago to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $764 (Avianca) |
One-way from | $397 (Kiwi.com) |
Popular in | June |
Cheapest in | November |
Average price | $771 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 28, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Sun 12/6
4:15 pm-11:55 am
2 stops48h 40m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$497
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Fri 10/9
5:22 am-12:15 am
3 stops46h 53m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$580
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Fri 2/19
10:45 pm-12:33 pm
1 stop18h 48m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$653
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Fri 12/25
7:40 am-10:26 pm
2 stops19h 46m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$654
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Tue 12/29
9:45 am-12:20 am
2 stops19h 35m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$658
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Sat 3/20
9:45 pm-7:20 am
1 stop37h 35m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$659
Quickest round-trip
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Sun 11/15
10:45 pm-12:19 pm
1 stop18h 34m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$659
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Mon 3/22
9:45 pm-11:59 pm
1 stop30h 14m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$659
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Thu 1/14
10:45 pm-11:59 pm
1 stop30h 14m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$660
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Fri 12/11
8:35 am-12:40 pm
3 stops33h 05m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$682
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Santiago to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to San Francisco in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*2 stars |
- Most accurate provider: When it comes to deals on Santiago-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santiago-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santiago to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.
SCL-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santiago to San Francisco
How far ahead should I book a flight from Santiago to San Francisco?
The price you pay for your flight from Santiago to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 6 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Santiago to San Francisco?
Currently, November is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $607). Flying from Santiago to San Francisco in June is currently the most expensive (average of $787). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Santiago to San Francisco?
Airfare is typical for this route at the moment.
Santiago to San Francisco flights typically cost between $557 and $945 in November.The cheapest round-trip price found within the last 5 days was $764 on Avianca (Nov 12-Jan 18).
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated September 28, 2026.
Peruse reviews from past customers who have flown with Delta,Copa Airlines, andLATAM Airlines from Santiago to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Food
7.2
Entertainment
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.8
Food
7.2
Entertainment
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.8
Food
7.2
Entertainment
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.8
Food
7.2
Entertainment
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.8
Food
7.2
Entertainment
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.8
Food
7.2
Entertainment
7.8
Comfort
7.8
Crew
8.5
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Santiago to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Emeryville
Burlingame
Rancho Cordova
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Alternative routes for Santiago to San Francisco
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Santiago and San Francisco flights
Browse other Santiago and San Francisco flight options. Last updated on September 28, 2026.
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Browse through other flights departing from Santiago. Flights are based on user searches made on Cheapflights and were last updated on September 28, 2026.
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Check out other popular destinations found by fellow travelers in 2026
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Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 28, 2026.
Top 6 airlines flying from Santiago to San Francisco
Discover the top 6 airlines that operate flights from Santiago to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$311 | Average$757 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$448 | Average$638 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$481 | Average$824 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$494 | Average$667 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$531 | Average$735 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$571 | Average$720 | FlexibilityNo cancel fee | On-time69% |