$266+ Cheap flights from Santiago (SCL) to San Francisco (SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/28. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — SFO
Sep 1 — Sep 81
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Santiago to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santiago to San Francisco
Cheapest
Best
Last-minute
One-way
Cheapest flights from Santiago to San FranciscoExplore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 2, 2026.
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 2, 2026.
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/110:45 pm
SCL
- SFO
1 stop18h 34m
United Airlines
Sun 11/811:15 pm
SFO
- SCL
1 stop28h 35m
United Airlines
Deal found 7/29![United Airlines logo]()
$546
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/212:40 am
SCL
- SFO
2 stops26h 18m
Delta
Thu 9/107:20 am
SFO
- SCL
1 stop18h 15m
Delta
Deal found 7/28![Delta logo]()
$548
This SmartFares deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/311:25 pm
SCL
- SFO
1 stop17h 06m
Multiple Airlines
Sat 9/193:41 pm
SFO
- SCL
1 stop33h 54m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$549
This LATAM Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/25:40 am
SCL
- SFO
2 stops19h 35m
LATAM Airlines
Sun 9/610:00 pm
SFO
- SCL
2 stops29h 00m
LATAM Airlines
Deal found 7/28![LATAM Airlines logo]()
$550
This FlightHub deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:40 am
SCL
- SFO
2 stops33h 10m
Avianca
Sun 8/2311:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 7/29![Avianca logo]()
$552
This LATAM Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1012:05 am
SCL
- SFO
2 stops25h 46m
LATAM Airlines
Sun 9/2011:30 pm
SFO
- SCL
2 stops27h 30m
LATAM Airlines
Deal found 7/28![LATAM Airlines logo]()
$553
This LATAM Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/411:05 pm
SCL
- SFO
2 stops27h 53m
LATAM Airlines
Thu 9/1010:00 pm
SFO
- SCL
2 stops28h 55m
LATAM Airlines
Deal found 7/28![LATAM Airlines logo]()
$555
This SmartFares deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2811:25 pm
SCL
- SFO
1 stop14h 24m
LATAM Airlines
Fri 9/49:30 am
SFO
- SCL
1 stop17h 05m
LATAM Airlines
Deal found 7/29![LATAM Airlines logo]()
$556
This Expedia deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/111:55 pm
SCL
- SFO
1 stop15h 33m
Multiple Airlines
Sun 11/810:30 pm
SFO
- SCL
2 stops26h 05m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$558
This Avianca deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:40 am
SCL
- SFO
2 stops20h 15m
Avianca
Thu 8/132:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 7/29![Avianca logo]()
$561
This LATAM Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2511:00 pm
SCL
- SFO
2 stops38h 17m
LATAM Airlines
Mon 9/79:30 am
SFO
- SCL
1 stop16h 05m
LATAM Airlines
Deal found 7/29![LATAM Airlines logo]()
$565
This FlightHub deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:40 am
SCL
- SFO
2 stops57h 10m
Avianca
Sun 8/2311:55 pm
SFO
- SCL
2 stops35h 20m
Avianca
Deal found 7/29![Avianca logo]()
$569
Best flights from Santiago to San FranciscoDiscover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 2, 2026.
Discover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 2, 2026.
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/110:45 pm
SCL
- SFO
1 stop18h 34m
United Airlines
Sun 11/811:15 pm
SFO
- SCL
1 stop28h 35m
United Airlines
Deal found 7/29![United Airlines logo]()
$546
This Copa Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:02 am
SCL
- SFO
1 stop21h 23m
Copa Airlines
Sun 11/87:36 pm
SFO
- SCL
1 stop23h 00m
Copa Airlines
Deal found 7/29![Copa Airlines logo]()
$561
This LATAM Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/111:35 pm
SCL
- SFO
2 stops35h 35m
Multiple Airlines
Wed 9/167:20 am
SFO
- SCL
2 stops32h 25m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$637
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/111:55 pm
SCL
- SFO
1 stop14h 58m
Delta
Sat 10/316:00 am
SFO
- SCL
2 stops20h 55m
Delta
Deal found 8/2![Delta logo]()
$666
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/710:45 pm
SCL
- SFO
1 stop18h 34m
United Airlines
Wed 11/117:15 am
SFO
- SCL
1 stop20h 35m
United Airlines
Deal found 7/29![United Airlines logo]()
$583
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/119:50 pm
SCL
- SFO
1 stop25h 58m
Delta
Mon 3/2910:45 pm
SFO
- SCL
1 stop28h 05m
Delta
Deal found 8/1![Delta logo]()
$666
This Copa Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2612:22 pm
SCL
- SFO
1 stop33h 48m
Copa Airlines
Sun 9/278:21 pm
SFO
- SCL
1 stop26h 25m
Copa Airlines
Deal found 7/30![Copa Airlines logo]()
$686
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2011:55 pm
SCL
- SFO
1 stop20h 13m
Delta
Sun 1/36:00 am
SFO
- SCL
1 stop19h 40m
Delta
Deal found 7/30![Delta logo]()
$666
This LATAM Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/295:55 pm
SCL
- SFO
2 stops46h 56m
Multiple Airlines
Sat 2/207:00 am
SFO
- SCL
1 stop17h 35m
Multiple Airlines
Deal found 8/1![Multiple Airlines logo]()
$738
This Copa Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:43 am
SCL
- SFO
1 stop20h 27m
Copa Airlines
Thu 10/18:21 pm
SFO
- SCL
1 stop24h 01m
Copa Airlines
Deal found 8/2![Copa Airlines logo]()
$686
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1810:55 pm
SCL
- SFO
1 stop22h 29m
Delta
Sun 8/237:13 am
SFO
- SCL
2 stops19h 22m
Delta
Deal found 7/29![Delta logo]()
$699
Last-minute flights from Santiago to San FranciscoDiscover last-minute flight deals from Santiago to San Francisco. Data last updated August 2, 2026 and is based on user searches.
Discover last-minute flight deals from Santiago to San Francisco. Data last updated August 2, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:40 am
SCL
- SFO
2 stops20h 15m
Avianca
Thu 8/132:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 7/29![Avianca logo]()
$561
This FlightHub deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:40 am
SCL
- SFO
2 stops57h 10m
Avianca
Sun 8/2311:55 pm
SFO
- SCL
2 stops35h 20m
Avianca
Deal found 7/29![Avianca logo]()
$569
This FlightHub deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:40 am
SCL
- SFO
2 stops33h 10m
Avianca
Sun 8/2311:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 7/29![Avianca logo]()
$552
This oojo deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:40 am
SCL
- SFO
3 stops50h 45m
Avianca
Sat 8/227:45 am
SFO
- SCL
3 stops36h 35m
Avianca
Deal found 7/28![Avianca logo]()
$572
This Avianca deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Tue 8/2511:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 7/30![Avianca logo]()
$604
This LATAM Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2511:00 pm
SCL
- SFO
2 stops38h 17m
LATAM Airlines
Mon 9/79:30 am
SFO
- SCL
1 stop16h 05m
LATAM Airlines
Deal found 7/29![LATAM Airlines logo]()
$565
This oojo deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/259:30 pm
SCL
- SFO
2 stops39h 47m
Multiple Airlines
Mon 8/318:57 pm
SFO
- SCL
1 stop29h 38m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$580
This Avianca deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Fri 9/411:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 7/29![Avianca logo]()
$548
This SmartFares deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2811:25 pm
SCL
- SFO
1 stop14h 24m
LATAM Airlines
Fri 9/49:30 am
SFO
- SCL
1 stop17h 05m
LATAM Airlines
Deal found 7/29![LATAM Airlines logo]()
$556
This Avianca deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/303:20 pm
SCL
- SFO
2 stops24h 30m
Avianca
Sat 9/1211:55 pm
SFO
- SCL
2 stops25h 50m
Avianca
Deal found 7/28![Avianca logo]()
$590
This LATAM Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/3112:35 pm
SCL
- SFO
2 stops34h 04m
LATAM Airlines
Sat 9/126:00 am
SFO
- SCL
2 stops21h 00m
LATAM Airlines
Deal found 7/28![LATAM Airlines logo]()
$550
One-way flights from Santiago to San FranciscoSearch for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated August 2, 2026.
Search for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated August 2, 2026.
This Avianca deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Deal found 7/29![Avianca logo]()
$266
This Avianca deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/287:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Deal found 7/28![Avianca logo]()
$268
This FlightHub deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/121:30 am
SCL
- SFO
2 stops39h 20m
Avianca
Deal found 7/29![Avianca logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:40 am
SCL
- SFO
2 stops20h 15m
Avianca
Deal found 7/30![Avianca logo]()
$277
This Avianca deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:40 am
SCL
- SFO
2 stops20h 15m
Avianca
Deal found 7/29![Avianca logo]()
$278
This Avianca deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/117:25 am
SCL
- SFO
2 stops19h 25m
Avianca
Deal found 7/29![Avianca logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:40 am
SCL
- SFO
2 stops20h 15m
Avianca
Deal found 7/30![Avianca logo]()
$299
This eDestinos deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/214:20 pm
SCL
- SFO
2 stops35h 35m
Avianca
Deal found 7/29![Avianca logo]()
$302
This eDestinos deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:40 am
SCL
- SFO
2 stops26h 45m
Avianca
Deal found 7/29![Avianca logo]()
$303
This Avianca deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Deal found 7/31![Avianca logo]()
$310
This Avianca deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/227:25 am
SCL
- SFO
2 stops19h 25m
Avianca
Deal found 7/29![Avianca logo]()
$312
Find flight deals from Santiago to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $546 (United Airlines) |
One-way from | $266 (Avianca) |
Popular in | June |
Cheapest in | October |
Average price | $660 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 2, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Sun 11/1
10:45 pm-12:19 pm
1 stop18h 34m
San Francisco
Sun 11/8
11:15 pm-8:50 am
1 stop28h 35m
$546
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Sat 10/31
1:02 am-6:25 pm
1 stop21h 23m
San Francisco
Sun 11/8
7:36 pm-11:36 pm
1 stop23h 00m
$561
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Sat 11/7
10:45 pm-12:19 pm
1 stop18h 34m
San Francisco
Wed 11/11
7:15 am-8:50 am
1 stop20h 35m
$583
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Fri 9/11
1:35 pm-9:10 pm
2 stops35h 35m
San Francisco
Wed 9/16
7:20 am-7:45 pm
2 stops32h 25m
$637
Quickest round-trip
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Thu 10/1
11:55 pm-10:53 am
1 stop14h 58m
San Francisco
Sat 10/31
6:00 am-6:55 am
2 stops20h 55m
$666
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Fri 12/11
9:50 pm-6:48 pm
1 stop25h 58m
San Francisco
Mon 3/29
10:45 pm-6:50 am
1 stop28h 05m
$666
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Sun 12/20
11:55 pm-3:08 pm
1 stop20h 13m
San Francisco
Sun 1/3
6:00 am-6:40 am
1 stop19h 40m
$666
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Sat 9/26
12:22 pm-6:10 pm
1 stop33h 48m
San Francisco
Sun 9/27
8:21 pm-2:46 am
1 stop26h 25m
$686
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Wed 9/23
1:43 am-6:10 pm
1 stop20h 27m
San Francisco
Thu 10/1
8:21 pm-12:22 am
1 stop24h 01m
$686
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Tue 8/18
10:55 pm-6:24 pm
1 stop22h 29m
San Francisco
Sun 8/23
7:13 am-5:35 am
2 stops19h 22m
$699
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Santiago to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to San Francisco in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*2 stars |
- Most accurate provider: When it comes to deals on Santiago-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santiago-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santiago to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.
SCL-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santiago to San Francisco
How far ahead should I book a flight from Santiago to San Francisco?
The price you pay for your flight from Santiago to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 6 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Santiago to San Francisco?
Currently, October is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $553). Flying from Santiago to San Francisco in June is currently the most expensive (average of $788). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Santiago to San Francisco?
Airfare is below average for this route at the moment.
Santiago to San Francisco flights typically cost between $577 and $787 in November.The cheapest round-trip price found within the last 5 days was $546 on United Airlines (Nov 1-Nov 8).
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated August 2, 2026.
Peruse reviews from past customers who have flown with Delta,Copa Airlines, andLATAM Airlines from Santiago to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Overall
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Overall
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Overall
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Overall
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Overall
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Overall
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Santiago to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Fairfield
Emeryville
Roseville
Burlingame
Rancho Cordova
San Bruno
Cupertino
Newark
Hayward
San Ramon
Redwood City
San Carlos
Turlock
Vallejo
San Lorenzo
Davis
Vacaville
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Santiago
Popular flights
San Francisco flight routes
Alternative routes for Santiago to San Francisco
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to San Francisco by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Santiago to San Francisco by cabin class
Find flights from Santiago to San Francisco, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Santiago and San Francisco flights
Browse other Santiago and San Francisco flight options. Last updated on August 2, 2026.
Other flights from Santiago
Browse through other flights departing from Santiago. Flights are based on user searches made on Cheapflights and were last updated on August 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 2, 2026.
Top 6 airlines flying from Santiago to San Francisco
Discover the top 6 airlines that operate flights from Santiago to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$311 | Average$673 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$433 | Average$612 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$481 | Average$705 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$494 | Average$660 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$509 | Average$725 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$571 | Average$710 | FlexibilityNo cancel fee | On-time69% |