HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Francisco

$249+ Cheap flights from Santiago (SCL) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/31. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — SFO
Nov 22 — Nov 291
Sat 11/22
Sat 11/29
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Santiago to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Santiago Arturo Merino Benitez to San Francisco are usually found in October or September, booked 76 days in advance, depart on a Saturday or Thursday and return on a Wednesday

Find flight deals from Santiago to San Francisco

Cheapest flights from Santiago to San Francisco
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/34:25 pmSCL - SFO
2 stops34h 25mAvianca
Mon 2/91:20 pmSFO - SCL
2 stops21h 00mAvianca
Deal found 10/23$485
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/311:15 pmSCL - SFO
1 stop23h 07mAmerican Airlines
Thu 11/278:00 amSFO - SCL
1 stop19h 00mAmerican Airlines
Deal found 10/23$504
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/610:25 pmSCL - SFO
1 stop27h 35mAmerican Airlines
Sun 11/1611:59 pmSFO - SCL
1 stop26h 56mAmerican Airlines
Deal found 10/21$505
This Cheapflightsfares deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/64:25 pmSCL - SFO
2 stops34h 25mAvianca
Wed 11/261:20 pmSFO - SCL
2 stops21h 00mAvianca
Deal found 10/22$510
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/311:15 pmSCL - SFO
2 stops19h 14mAmerican Airlines
Wed 11/128:20 amSFO - SCL
2 stops19h 40mAmerican Airlines
Deal found 10/22$511
This Gotogate deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/34:25 pmSCL - SFO
2 stops24h 35mAvianca
Sat 11/151:35 amSFO - SCL
2 stops22h 55mAvianca
Deal found 10/23$512
This LATAM Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1811:55 pmSCL - SFO
1 stop14h 49mLATAM Airlines
Tue 1/2711:30 amSFO - SCL
1 stop14h 30mLATAM Airlines
Deal found 10/22$532
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1811:15 pmSCL - SFO
1 stop17h 06mAmerican Airlines
Tue 1/279:00 amSFO - SCL
2 stops19h 05mAmerican Airlines
Deal found 10/22$534
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1711:10 pmSCL - SFO
1 stop20h 33mDelta
Mon 1/267:00 amSFO - SCL
1 stop18h 55mDelta
Deal found 10/22$535

Cheap flight deals from Santiago to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 23, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$504
(American Airlines)

One-way from

$249
(Cheapflightsfares)

Popular in

January

Cheapest in

October

Average price

$564
Provider with most accurate pricing for Santiago Arturo Merino Benitez-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santiago Arturo Merino Benitez-San Francisco flights.
Search Deals
From Santiago Arturo Merino Benitez to San Francisco
Search Deals
One-way flight from Santiago Arturo Merino Benitez to San Francisco
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($94 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Santiago

Fly to

San Francisco

Route

Depart

Return

Price

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 11/3

5:12 am-11:17 pm

1 stop23h 05m

San Francisco

Tue 11/11

12:36 am-12:06 am

1 stop18h 30m

$532

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 11/18

11:10 pm-12:30 pm

1 stop18h 20m

San Francisco

Tue 1/27

6:00 am-7:00 am

1 stop20h 00m

$535

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 3/10

11:15 pm-9:46 pm

1 stop26h 31m

San Francisco

Mon 3/23

6:00 am-7:00 am

1 stop21h 00m

$535

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 11/10

11:25 pm-5:38 pm

2 stops23h 13m

San Francisco

Mon 1/12

6:00 am-7:00 am

1 stop20h 00m

$535

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 12/25

10:45 pm-9:11 pm

1 stop27h 26m

San Francisco

Sun 12/28

2:57 pm-8:50 am

1 stop36h 53m

$536

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 12/24

11:10 pm-8:42 pm

1 stop26h 32m

San Francisco

Tue 12/30

6:00 am-6:10 am

1 stop19h 10m

$538

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 12/24

11:10 pm-8:42 pm

1 stop26h 32m

San Francisco

Wed 12/31

6:00 am-6:25 am

2 stops19h 25m

$538

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 12/23

10:45 pm-6:59 pm

1 stop25h 14m

San Francisco

Wed 12/31

9:01 am-8:50 am

1 stop18h 49m

$558

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Fri 12/19

10:45 pm-12:21 am

1 stop30h 36m

San Francisco

Sun 1/4

4:10 pm-8:50 am

1 stop35h 40m

$571

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 11/6

4:25 pm-9:50 pm

2 stops34h 25m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/23

Showing 1-10 of 20 results
1
2

Compare providers for flights from Santiago to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to San Francisco in October.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy3 starsTrust Score*3 stars
Justfly.comPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santiago-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santiago-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to San Francisco

How far ahead should I book a flight from Santiago to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Santiago to San Francisco. Price data was last updated on October 17, 2025.

The price you pay for your flight from Santiago to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 76 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santiago to San Francisco?

Currently, February is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $429). Flying from Santiago to San Francisco in January is currently the most expensive (average of $572). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SCL to SFO?

Find hourly flight availability from Santiago to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 23, 2025.

It’s typically best to fly out from Santiago to San Francisco in the afternoon. Doing so could potentially save you 31% on the flight price compared to flying in the evening, which is usually more expensive.

How much does it cost to fly round-trip from Santiago to San Francisco?

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated October 23, 2025.
Peruse reviews from past customers who have flown with Delta, Copa Airlines, and LATAM Airlines from Santiago to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,981 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
7.9
Good
7,981 reviews
Delta
7.9
Good
7,981 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Copa Airlines
7.6
Good
1,558 reviews
Delta
7.9
Good
7,981 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
LATAM Airlines
7.5
Good
1,870 reviews
Delta
7.9
Good
7,981 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
11,028 reviews
Delta
7.9
Good
7,981 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Avianca
6.7
Okay
2,460 reviews
Delta
7.9
Good
7,981 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Santiago to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santiago to San Francisco?

    Departing from Santiago to San Francisco will take you 18h 20m. The distance from Santiago to San Francisco is about 5918 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Santiago to San Francisco round-trip?

    Currently priced at $408, Avianca will fly you from Santiago to San Francisco and back. In addition to Avianca, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Copa Airlines - these airlines can fly you to your destination from $481 and $511, respectively. Avianca is priced at 39% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Santiago to San Francisco that include hotel bookings?

    Yes. In addition to deals on Santiago to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to San Francisco.

  • Can I find deals for business class flights from Santiago to San Francisco?

    Yes. Cheapflights offers flight deals from Santiago to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to San Francisco?

    Currently, February is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $429). Flying from Santiago to San Francisco in January is currently the most expensive (average of $572). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
Santa Cruz
Livermore
South San Francisco
Turlock
Antioch
Watsonville
Santa Clara
Manteca
Sunnyvale
Vacaville
Vallejo
Hollister
Foster City
Union City
Fairfield
Burlingame
Redwood City
Lodi
San Mateo

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 5 airlines flying from Santiago to San Francisco

Discover the top 5 airlines that operate flights from Santiago to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$408Average$714FlexibilityNo cancel feeOn-time71%
American AirlinesCheapest$481Average$872FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$511Average$626FlexibilityNo cancel feeOn-time70%
LATAM AirlinesCheapest$518Average$708FlexibilityNo cancel feeOn-time81%
DeltaCheapest$547Average$745FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.