How long is the flight from Santiago to San Francisco?

Departing from Santiago to San Francisco will take you 21h 06m. The distance from Santiago to San Francisco is about 5918 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What are the cheapest airlines flying from Santiago to San Francisco round-trip?

Currently priced at $408, Avianca will fly you from Santiago to San Francisco and back. In addition to Avianca, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Copa Airlines - these airlines can fly you to your destination from $481 and $511, respectively. Avianca is priced at 38% lower than the current average price of a flight leaving 3 months from now.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What are the most popular airlines that fly from Santiago to San Francisco?

When booking a flight from Santiago to San Francisco, you may want to consider flying on LATAM Airlines, Delta or American Airlines as they are the most popular for this route.

Most accurate provider : When it comes to deals on Santiago-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santiago-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santiago-San Francisco flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Santiago-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Santiago to San Francisco that include hotel bookings?

Yes. In addition to deals on Santiago to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Santiago to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to San Francisco.

Can I find deals for business class flights from Santiago to San Francisco?

Yes. Cheapflights offers flight deals from Santiago to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$271+ Flights from Santiago to San Francisco

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

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Cheapflights Tip: The best prices from Santiago Arturo Merino Benitez to San Francisco are usually found in October or September, booked 76 days in advance, depart on a Saturday or Thursday and return on a Wednesday

Find flight deals from Santiago to San Francisco

Cheapest flights from Santiago to San Francisco
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

Tue 12/211:15 pmSCL - SFO

1 stop23h 05mAmerican Airlines

Mon 12/86:00 amSFO - SCL

1 stop20h 45mAmerican Airlines

Deal found 11/25

$505

Tue 12/1611:55 pmSCL - SFO

1 stop19h 41mLATAM Airlines

Sat 1/36:00 amSFO - SCL

1 stop18h 35mLATAM Airlines

Deal found 11/26

$512

Wed 12/179:30 pmSCL - SFO

1 stop18h 00mLATAM Airlines

Sun 1/46:00 amSFO - SCL

1 stop18h 35mLATAM Airlines

Deal found 11/26

$516

Mon 12/1511:10 pmSCL - SFO

1 stop18h 26mDelta

Fri 3/276:00 amSFO - SCL

1 stop19h 35mDelta

Deal found 11/24

$522

Wed 12/249:30 pmSCL - SFO

1 stop18h 13mDelta

Wed 12/316:00 amSFO - SCL

1 stop20h 40mDelta

Deal found 11/24

$525

Wed 12/2410:45 pmSCL - SFO

1 stop23h 07mUnited Airlines

Sun 3/1511:59 pmSFO - SCL

1 stop27h 51mUnited Airlines

Deal found 11/25

$526

Fri 12/1211:15 pmSCL - SFO

1 stop26h 41mAmerican Airlines

Mon 3/2312:30 amSFO - SCL

1 stop26h 20mAmerican Airlines

Deal found 11/24

$531

Thu 12/410:45 pmSCL - SFO

1 stop23h 01mUnited Airlines

Mon 12/811:15 amSFO - SCL

1 stop16h 35mUnited Airlines

Deal found 11/23

$534

Wed 12/1711:15 pmSCL - SFO

2 stops21h 32mAmerican Airlines

Sun 1/46:00 amSFO - SCL

1 stop20h 45mAmerican Airlines

Deal found 11/26

$539

Sat 12/1311:55 pmSCL - SFO

2 stops20h 12mAmerican Airlines

Tue 1/611:51 amSFO - SCL

1 stop15h 24mAmerican Airlines

Deal found 11/25

$540

Best flights from Santiago to San Francisco
Discover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 26, 2025.

Thu 12/1810:45 pmSCL - SFO

1 stop21h 06mUnited Airlines

Sun 1/45:15 amSFO - SCL

1 stop22h 35mUnited Airlines

Deal found 11/24

$522

Wed 12/2411:10 pmSCL - SFO

1 stop26h 32mDelta

Sat 1/177:00 amSFO - SCL

2 stops19h 40mDelta

Deal found 11/26

$525

Tue 1/277:25 amSCL - SFO

2 stops20h 55mAvianca

Wed 2/41:20 pmSFO - SCL

2 stops21h 00mAvianca

Deal found 11/24

$553

Wed 12/2411:10 pmSCL - SFO

1 stop16h 33mDelta

Sun 1/186:00 amSFO - SCL

1 stop20h 40mDelta

Deal found 11/25

$525

Mon 2/910:45 pmSCL - SFO

1 stop21h 11mUnited Airlines

Sun 2/2212:43 amSFO - SCL

1 stop27h 07mUnited Airlines

Deal found 11/25

$526

Wed 12/2410:45 pmSCL - SFO

1 stop24h 13mUnited Airlines

Mon 3/165:00 amSFO - SCL

1 stop22h 50mUnited Airlines

Deal found 11/25

$526

Mon 4/1311:00 pmSCL - SFO

2 stops21h 10mDelta

Wed 5/66:00 amSFO - SCL

1 stop22h 00mDelta

Deal found 11/23

$552

Tue 4/1411:00 pmSCL - SFO

2 stops21h 10mDelta

Wed 5/66:00 amSFO - SCL

2 stops20h 35mDelta

Deal found 11/23

$552

Tue 12/1610:45 pmSCL - SFO

1 stop18h 24mUnited Airlines

Sat 1/311:59 pmSFO - SCL

1 stop27h 51mUnited Airlines

Deal found 11/24

$553

Thu 4/164:10 amSCL - SFO

2 stops23h 05mDelta

Sat 5/911:45 pmSFO - SCL

2 stops26h 50mDelta

Deal found 11/23

$576

Wed 4/1511:00 pmSCL - SFO

2 stops23h 35mDelta

Fri 5/86:00 amSFO - SCL

2 stops21h 55mDelta

Deal found 11/23

$576

Last-minute flights from Santiago to San Francisco
Discover last-minute flight deals from Santiago to San Francisco. Data last updated November 26, 2025 and is based on user searches.

Tue 12/211:15 pmSCL - SFO

1 stop23h 05mAmerican Airlines

Mon 12/86:00 amSFO - SCL

1 stop20h 45mAmerican Airlines

Deal found 11/25

$505

Tue 12/210:45 pmSCL - SFO

1 stop18h 24mUnited Airlines

Mon 12/2911:59 pmSFO - SCL

1 stop27h 51mUnited Airlines

Deal found 11/23

$522

Tue 12/211:10 pmSCL - SFO

2 stops20h 26mLATAM Airlines

Sun 12/76:00 amSFO - SCL

2 stops20h 40mLATAM Airlines

Deal found 11/23

$535

Tue 12/211:15 pmSCL - SFO

2 stops21h 48mAmerican Airlines

Mon 12/2911:59 pmSFO - SCL

1 stop26h 46mAmerican Airlines

Deal found 11/23

$548

Tue 12/210:45 pmSCL - SFO

1 stop18h 24mUnited Airlines

Sun 12/79:10 amSFO - SCL

1 stop18h 40mUnited Airlines

Deal found 11/26

$551

Tue 12/211:15 pmSCL - SFO

2 stops19h 18mAmerican Airlines

Sun 12/79:15 amSFO - SCL

2 stops17h 55mAmerican Airlines

Deal found 11/26

$564

Tue 12/211:10 pmSCL - SFO

2 stops20h 26mMultiple Airlines

Mon 12/298:20 amSFO - SCL

2 stops26h 10mMultiple Airlines

Deal found 11/23

$618

Thu 12/410:45 pmSCL - SFO

1 stop23h 01mUnited Airlines

Mon 12/811:15 amSFO - SCL

1 stop16h 35mUnited Airlines

Deal found 11/23

$534

Thu 12/49:30 pmSCL - SFO

1 stop18h 00mLATAM Airlines

Mon 12/88:15 amSFO - SCL

2 stops17h 45mLATAM Airlines

Deal found 11/23

$539

Thu 12/412:20 pmSCL - SFO

1 stop15h 57mCopa Airlines

Sun 12/712:36 amSFO - SCL

1 stop18h 48mCopa Airlines

Deal found 11/23

$620

One-way flights from Santiago to San Francisco
Search for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated November 26, 2025.

Wed 3/181:35 amSCL - SFO

2 stops26h 05mAvianca

Deal found 11/24

$271

Tue 2/247:25 amSCL - SFO

2 stops20h 55mAvianca

Deal found 11/26

$278

Mon 3/161:35 amSCL - SFO

2 stops26h 05mAvianca

Deal found 11/24

$286

Wed 1/214:25 pmSCL - SFO

2 stops35h 55mAvianca

Deal found 11/25

$293

Fri 12/124:25 pmSCL - SFO

2 stops35h 55mAvianca

Deal found 11/24

$303

Mon 1/261:35 amSCL - SFO

2 stops26h 45mAvianca

Deal found 11/25

$306

Wed 1/281:35 amSCL - SFO

2 stops26h 45mAvianca

Deal found 11/25

$314

Thu 3/191:35 amSCL - SFO

2 stops50h 05mAvianca

Deal found 11/25

$318

Wed 12/171:35 amSCL - SFO

2 stops26h 45mAvianca

Deal found 11/25

$321

Thu 1/227:25 amSCL - SFO

2 stops20h 55mAvianca

Deal found 11/25

$322

Wed 12/107:25 amSCL - SFO

2 stops44h 55mAvianca

Deal found 11/25

$323

Cheap flight deals from Santiago to San Francisco

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$512 (LATAM Airlines)
One-way from	$271 (Mytrip)
Popular in	January
Cheapest in	October
Average price	$588

Provider with most accurate pricing for Santiago Arturo Merino Benitez-San Francisco flight deals.

Search Deals

Provider most trusted by Cheapflights users for Santiago Arturo Merino Benitez-San Francisco flights.

Search Deals

From Santiago Arturo Merino Benitez to San Francisco

Search Deals

One-way flight from Santiago Arturo Merino Benitez to San Francisco

Search Deals

Highest demand for flights based on searches. 10% potential increase in price ($75 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($13 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in November 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 12/18

10:45 pm-2:51 pm

1 stop21h 06m

San Francisco

Sun 1/4

5:15 am-8:50 am

1 stop22h 35m

$522

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 12/24

11:10 pm-8:42 pm

1 stop26h 32m

San Francisco

Sat 1/17

7:00 am-7:40 am

2 stops19h 40m

$525

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 12/24

11:10 pm-10:43 am

1 stop16h 33m

San Francisco

Sun 1/18

6:00 am-7:40 am

1 stop20h 40m

$525

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 2/9

10:45 pm-2:56 pm

1 stop21h 11m

San Francisco

Sun 2/22

12:43 am-8:50 am

1 stop27h 07m

$526

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 12/24

10:45 pm-5:58 pm

1 stop24h 13m

San Francisco

Mon 3/16

5:00 am-7:50 am

1 stop22h 50m

$526

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 4/13

11:00 pm-5:10 pm

2 stops21h 10m

San Francisco

Wed 5/6

6:00 am-7:00 am

1 stop22h 00m

$552

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 4/14

11:00 pm-5:10 pm

2 stops21h 10m

San Francisco

Wed 5/6

6:00 am-5:35 am

2 stops20h 35m

$552

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 1/27

7:25 am-11:20 pm

2 stops20h 55m

San Francisco

Wed 2/4

1:20 pm-3:20 pm

2 stops21h 00m

$553

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 12/16

10:45 pm-12:09 pm

1 stop18h 24m

San Francisco

Sat 1/3

11:59 pm-8:50 am

1 stop27h 51m

$553

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 4/16

4:10 am-12:15 am

2 stops23h 05m

San Francisco

Sat 5/9

11:45 pm-5:35 am

2 stops26h 50m

$576

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/24

Showing 1-10 of 23 results

Compare providers for flights from Santiago to San Francisco

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to San Francisco in November.

Provider	Price Accuracy	Trust Score*
eDreams	Price Accuracy3 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
AranGrant	Price Accuracy2 stars	Trust Score*3 stars
Justfly.com	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Santiago-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santiago-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santiago-San Francisco flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Santiago-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to San Francisco

How far ahead should I book a flight from Santiago to San Francisco?

The price you pay for your flight from Santiago to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 76 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santiago to San Francisco?

Currently, February is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $425). Flying from Santiago to San Francisco in April is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SCL to SFO?

It’s typically best to fly out from Santiago to San Francisco in the afternoon. Doing so could potentially save you 31% on the flight price compared to flying in the evening, which is usually more expensive.

Reviews of airlines servicing San Francisco

Peruse reviews from past customers who have flown with Delta, Copa Airlines, and LATAM Airlines from Santiago to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

7,998 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta

7.9

Good

7,998 reviews

Delta

7.9

Good

7,998 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Copa Airlines

7.6

Good

1,569 reviews

Delta

7.9

Good

7,998 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

LATAM Airlines

7.5

Good

1,886 reviews

Delta

7.9

Good

7,998 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines

7.2

Good

11,038 reviews

Delta

7.9

Good

7,998 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Avianca

6.6

Okay

2,477 reviews

Delta

7.9

Good

7,998 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

How long is the flight from Santiago to San Francisco?
Departing from Santiago to San Francisco will take you 21h 06m. The distance from Santiago to San Francisco is about 5918 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines flying from Santiago to San Francisco round-trip?
Currently priced at $408, Avianca will fly you from Santiago to San Francisco and back. In addition to Avianca, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Copa Airlines - these airlines can fly you to your destination from $481 and $511, respectively. Avianca is priced at 38% lower than the current average price of a flight leaving 3 months from now.
Can I find deals for flights from Santiago to San Francisco that include hotel bookings?
Yes. In addition to deals on Santiago to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santiago to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to San Francisco.
Can I find deals for business class flights from Santiago to San Francisco?
Yes. Cheapflights offers flight deals from Santiago to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Santiago to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $425). Flying from Santiago to San Francisco in April is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Roseville

South San Francisco

Santa Cruz

Livermore

Turlock

Manteca

Watsonville

Sunnyvale

Santa Clara

San Bruno

Daly City

Redwood City

Vallejo

Hollister

Foster City

Milpitas

Union City

Davis

Hayward

Burlingame

Browse thousands of different options on Cheapflights for your next trip

Top 6 airlines flying from Santiago to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$408	Average$714	FlexibilityNo cancel fee	On-time71%
American Airlines	Cheapest$481	Average$891	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$511	Average$626	FlexibilityNo cancel fee	On-time70%
LATAM Airlines	Cheapest$518	Average$711	FlexibilityNo cancel fee	On-time81%
Delta	Cheapest$547	Average$745	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$603	Average$838	FlexibilityNo cancel fee	On-time69%

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$271+ Cheap flights from Santiago (SCL) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/18. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santiago to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Santiago Arturo Merino Benitez to San Francisco are usually found in October or September, booked 76 days in advance, depart on a Saturday or Thursday and return on a Wednesday

Find flight deals from Santiago to San Francisco

Cheapest flights from Santiago to San FranciscoExplore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

Cheap flight deals from Santiago to San Francisco

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Compare providers for flights from Santiago to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to San Francisco in November.

Best time to book a flight from Santiago to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Santiago to San Francisco

How far ahead should I book a flight from Santiago to San Francisco?

What is the cheapest month to book a flight from Santiago to San Francisco?

What is the cheapest time of day to fly from SCL to SFO?

Reviews of airlines servicing San Francisco

Peruse reviews from past customers who have flown with Delta, Copa Airlines, and LATAM Airlines from Santiago to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Santiago to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Santiago to San Francisco?

What are the cheapest airlines flying from Santiago to San Francisco round-trip?

Can I find deals for flights from Santiago to San Francisco that include hotel bookings?

How can I find direct flights from Santiago to San Francisco?

Can I find deals for business class flights from Santiago to San Francisco?

What is the cheapest month to book a flight from Santiago to San Francisco?

Traveling to a place near San Francisco?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Santiago to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top 6 airlines flying from Santiago to San Francisco

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Cheapest flights from Santiago to San Francisco
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.