$278+ Cheap flights from Santiago (SCL) to San Francisco (SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — SFO
Mar 13 — Mar 201
1 adult, Economy
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Cheapest flights from Santiago to San FranciscoExplore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.
This LATAM Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/278:30 am
SCL
- SFO
3 stops33h 51m
LATAM Airlines
Sun 5/36:00 am
SFO
- SCL
2 stops22h 15m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$522
This LATAM Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1710:30 am
SCL
- SFO
2 stops30h 06m
LATAM Airlines
Sun 6/147:00 am
SFO
- SCL
1 stop19h 35m
LATAM Airlines
Deal found 2/9![LATAM Airlines logo]()
$523
This Avianca deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:40 am
SCL
- SFO
2 stops20h 15m
Avianca
Mon 5/42:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 2/9![Avianca logo]()
$527
This LATAM Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:40 pm
SCL
- SFO
1 stop26h 39m
LATAM Airlines
Thu 4/2311:39 pm
SFO
- SCL
2 stops34h 56m
LATAM Airlines
Deal found 2/9![LATAM Airlines logo]()
$535
This LATAM Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:30 pm
SCL
- SFO
2 stops29h 49m
LATAM Airlines
Thu 4/3010:55 pm
SFO
- SCL
1 stop28h 55m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$538
This LATAM Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2211:05 pm
SCL
- SFO
2 stops23h 04m
LATAM Airlines
Mon 4/278:00 am
SFO
- SCL
2 stops27h 05m
LATAM Airlines
Deal found 2/8![LATAM Airlines logo]()
$539
This LATAM Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/38:40 pm
SCL
- SFO
2 stops21h 41m
LATAM Airlines
Wed 5/279:30 am
SFO
- SCL
2 stops18h 45m
LATAM Airlines
Deal found 2/9![LATAM Airlines logo]()
$540
This Avianca deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Thu 8/2011:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 2/8![Avianca logo]()
$542
This LATAM Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/611:00 pm
SCL
- SFO
2 stops23h 19m
LATAM Airlines
Mon 4/1312:06 pm
SFO
- SCL
1 stop16h 09m
LATAM Airlines
Deal found 2/8![LATAM Airlines logo]()
$544
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/158:35 pm
SCL
- SFO
1 stop27h 19m
American Airlines
Wed 5/66:15 am
SFO
- SCL
1 stop21h 50m
American Airlines
Deal found 2/7![American Airlines logo]()
$547
This LATAM Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/188:40 pm
SCL
- SFO
2 stops19h 56m
LATAM Airlines
Wed 6/177:00 am
SFO
- SCL
2 stops20h 50m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$550
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:40 pm
SCL
- SFO
1 stop21h 13m
Delta
Thu 8/206:00 am
SFO
- SCL
1 stop22h 15m
Delta
Deal found 2/9![Delta logo]()
$551
Best flights from Santiago to San FranciscoDiscover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 11, 2026.
Discover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 11, 2026.
This Avianca deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:40 am
SCL
- SFO
2 stops20h 15m
Avianca
Tue 5/2611:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 2/8![Avianca logo]()
$527
This LATAM Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:40 pm
SCL
- SFO
1 stop26h 39m
LATAM Airlines
Thu 4/2312:06 pm
SFO
- SCL
1 stop16h 09m
LATAM Airlines
Deal found 2/9![LATAM Airlines logo]()
$535
This Avianca deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:40 am
SCL
- SFO
2 stops20h 15m
Avianca
Mon 5/411:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 2/8![Avianca logo]()
$527
This LATAM Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:30 pm
SCL
- SFO
2 stops29h 49m
LATAM Airlines
Thu 4/3010:55 pm
SFO
- SCL
1 stop28h 55m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$538
This LATAM Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1311:05 pm
SCL
- SFO
2 stops23h 04m
LATAM Airlines
Thu 4/1611:00 am
SFO
- SCL
1 stop15h 35m
LATAM Airlines
Deal found 2/7![LATAM Airlines logo]()
$539
This Avianca deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Thu 8/2011:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 2/8![Avianca logo]()
$542
This LATAM Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/218:40 pm
SCL
- SFO
1 stop26h 44m
LATAM Airlines
Mon 5/410:35 pm
SFO
- SCL
2 stops28h 25m
LATAM Airlines
Deal found 2/9![LATAM Airlines logo]()
$539
This LATAM Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:30 pm
SCL
- SFO
2 stops29h 49m
LATAM Airlines
Mon 4/611:35 pm
SFO
- SCL
2 stops35h 00m
LATAM Airlines
Deal found 2/8![LATAM Airlines logo]()
$539
This LATAM Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2211:05 pm
SCL
- SFO
2 stops23h 04m
LATAM Airlines
Mon 4/278:00 am
SFO
- SCL
2 stops27h 05m
LATAM Airlines
Deal found 2/8![LATAM Airlines logo]()
$539
This LATAM Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:30 pm
SCL
- SFO
2 stops29h 39m
LATAM Airlines
Fri 4/1712:06 pm
SFO
- SCL
1 stop16h 09m
LATAM Airlines
Deal found 2/7![LATAM Airlines logo]()
$539
This LATAM Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/112:05 am
SCL
- SFO
2 stops23h 14m
LATAM Airlines
Thu 4/302:00 pm
SFO
- SCL
3 stops28h 15m
LATAM Airlines
Deal found 2/8![LATAM Airlines logo]()
$544
Last-minute flights from Santiago to San FranciscoDiscover last-minute flight deals from Santiago to San Francisco. Data last updated February 11, 2026 and is based on user searches.
Discover last-minute flight deals from Santiago to San Francisco. Data last updated February 11, 2026 and is based on user searches.
This Kissandfly.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2310:45 pm
SCL
- SFO
1 stop18h 26m
Lufthansa
Sun 3/85:00 am
SFO
- SCL
1 stop22h 50m
Lufthansa
Deal found 2/8![Lufthansa logo]()
$551
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2510:15 pm
SCL
- SFO
2 stops21h 20m
American Airlines
Tue 3/312:30 am
SFO
- SCL
1 stop26h 35m
American Airlines
Deal found 2/9![American Airlines logo]()
$523
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1010:15 pm
SCL
- SFO
1 stop25h 32m
American Airlines
Tue 5/56:15 am
SFO
- SCL
1 stop21h 50m
American Airlines
Deal found 2/8![American Airlines logo]()
$560
This KAYAK deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/108:50 pm
SCL
- SFO
2 stops21h 56m
LATAM Airlines
Fri 6/510:55 pm
SFO
- SCL
2 stops26h 55m
LATAM Airlines
Deal found 2/9![LATAM Airlines logo]()
$565
This CheapOair deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:55 pm
SCL
- SFO
1 stop35h 36m
Multiple Airlines
Fri 6/54:40 pm
SFO
- SCL
1 stop33h 55m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$582
This Avianca deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/107:25 am
SCL
- SFO
2 stops20h 15m
Avianca
Fri 6/511:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 2/8![Avianca logo]()
$588
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1810:15 pm
SCL
- SFO
1 stop23h 01m
American Airlines
Tue 3/3110:56 pm
SFO
- SCL
1 stop28h 54m
American Airlines
Deal found 2/9![American Airlines logo]()
$573
This Avianca deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/197:25 am
SCL
- SFO
2 stops20h 15m
Avianca
Fri 4/102:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 2/7![Avianca logo]()
$527
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1910:15 pm
SCL
- SFO
1 stop29h 01m
American Airlines
Tue 3/3110:56 pm
SFO
- SCL
1 stop28h 54m
American Airlines
Deal found 2/8![American Airlines logo]()
$564
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/259:20 pm
SCL
- SFO
2 stops21h 14m
American Airlines
Wed 4/16:00 am
SFO
- SCL
2 stops21h 50m
American Airlines
Deal found 2/8![American Airlines logo]()
$569
One-way flights from Santiago to San FranciscoSearch for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated February 11, 2026.
Search for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated February 11, 2026.
This Avianca deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:25 am
SCL
- SFO
2 stops20h 55m
Avianca
Deal found 2/9![Avianca logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/65:50 am
SCL
- SFO
3 stops40h 58m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:00 am
SCL
- SFO
3 stops38h 52m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$284
This Avianca deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:40 am
SCL
- SFO
2 stops20h 15m
Avianca
Deal found 2/9![Avianca logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:25 am
SCL
- SFO
2 stops19h 25m
Avianca
Deal found 2/8![Avianca logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/269:05 pm
SCL
- SFO
3 stops54h 16m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$302
This FlightHub deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/64:25 pm
SCL
- SFO
2 stops35h 55m
Avianca
Deal found 2/8![Avianca logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/249:05 pm
SCL
- SFO
3 stops29h 34m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/259:05 pm
SCL
- SFO
3 stops53h 34m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/99:05 pm
SCL
- SFO
3 stops30h 39m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$310
Find flight deals from Santiago to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $522 (LATAM Airlines) |
One-way from | $278 (Avianca) |
Popular in | June |
Cheapest in | October |
Average price | $571 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.
Fly from
Santiago
Fly to
San Francisco
Route
Depart
Return
Price
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Tue 5/5
6:40 am-11:55 pm
2 stops20h 15m
San Francisco
Tue 5/26
11:55 pm-11:20 pm
2 stops20h 25m
$527
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Tue 4/21
6:40 am-11:55 pm
2 stops20h 15m
San Francisco
Mon 5/4
11:55 pm-11:20 pm
2 stops20h 25m
$527
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Wed 4/1
8:40 pm-7:19 pm
1 stop26h 39m
San Francisco
Thu 4/23
12:06 pm-7:15 am
1 stop16h 09m
$535
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Wed 4/1
5:30 pm-7:19 pm
2 stops29h 49m
San Francisco
Thu 4/30
10:55 pm-6:50 am
1 stop28h 55m
$538
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Mon 4/13
11:05 pm-7:09 pm
2 stops23h 04m
San Francisco
Thu 4/16
11:00 am-5:35 am
1 stop15h 35m
$539
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Tue 4/21
8:40 pm-8:24 pm
1 stop26h 44m
San Francisco
Mon 5/4
10:35 pm-6:00 am
2 stops28h 25m
$539
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Wed 4/1
5:30 pm-7:19 pm
2 stops29h 49m
San Francisco
Mon 4/6
11:35 pm-1:35 pm
2 stops35h 00m
$539
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Wed 4/22
11:05 pm-7:09 pm
2 stops23h 04m
San Francisco
Mon 4/27
8:00 am-2:05 pm
2 stops27h 05m
$539
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Mon 4/13
4:30 pm-7:09 pm
2 stops29h 39m
San Francisco
Fri 4/17
12:06 pm-7:15 am
1 stop16h 09m
$539
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Thu 5/28
6:40 am-10:35 pm
2 stops18h 55m
San Francisco
Thu 8/20
11:55 pm-11:20 pm
2 stops20h 25m
$542
Showing 1-10 of 21 results
Compare providers for flights from Santiago to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to San Francisco in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*2 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Santiago-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santiago-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santiago to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.
SCL-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santiago to San Francisco
How far ahead should I book a flight from Santiago to San Francisco?
Use this chart to determine the optimal time to book a round-trip flight from Santiago to San Francisco. Price data was last updated on February 6, 2026.
The price you pay for your flight from Santiago to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 47 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Santiago to San Francisco?
Currently, October is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $465). Flying from Santiago to San Francisco in July is currently the most expensive (average of $554). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated February 11, 2026.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and Copa Airlines from Santiago to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Boarding
8.1
Entertainment
7.8
Food
7.2
Crew
8.5
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.9
Boarding
8.1
Entertainment
7.8
Food
7.2
Crew
8.5
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.9
Boarding
8.1
Entertainment
7.8
Food
7.2
Crew
8.5
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.9
Boarding
8.1
Entertainment
7.8
Food
7.2
Crew
8.5
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.9
Boarding
8.1
Entertainment
7.8
Food
7.2
Crew
8.5
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.9
Boarding
8.1
Entertainment
7.8
Food
7.2
Crew
8.5
Comfort
7.9
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Santiago to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSanta Cruz
South San Francisco
Santa Clara
Roseville
Livermore
Watsonville
San Bruno
Daly City
Sunnyvale
Turlock
Vacaville
San Carlos
San Ramon
Redwood City
Rancho Cordova
San Lorenzo
Davis
Hollister
Manteca
Union City
Browse thousands of different options on Cheapflights for your next trip
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Santiago and San Francisco flights
Browse other Santiago and San Francisco flight options. Last updated on February 11, 2026.
Other flights from Santiago
Browse through other flights departing from Santiago. Flights are based on user searches made on Cheapflights and were last updated on February 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 11, 2026.
Top 6 airlines flying from Santiago to San Francisco
Discover the top 6 airlines that operate flights from Santiago to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$433 | Average$640 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$481 | Average$613 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$508 | Average$700 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$511 | Average$601 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$554 | Average$744 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$571 | Average$710 | FlexibilityNo cancel fee | On-time69% |