$425+ Cheap flights from Santiago (SCL) to San Francisco (SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/23. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — SFO
Nov 24 — Dec 11
Round-trip
1 adult, Economy
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Find cheap flights from Santiago to San Francisco with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santiago to San Francisco
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Best
Last-minute
One-way
Cheapest flights from Santiago to San FranciscoExplore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
This Avianca deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:30 am -
2 stops19h 10m
Tue 12/81:15 pm -
2 stops20h 55m
Deal found 10/23![Avianca logo]()
$800
This Avianca deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:30 am -
2 stops19h 10m
Sun 1/311:15 pm -
2 stops20h 55m
Deal found 10/24![Avianca logo]()
$819
This SmartFares deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/39:55 pm -
1 stop22h 45m
Wed 1/138:40 am -
1 stop22h 35m
Deal found 10/22![Air Canada logo]()
$827
This Avianca deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:30 am -
2 stops19h 10m
Wed 12/21:15 pm -
2 stops20h 55m
Deal found 10/20![Avianca logo]()
$828
This Avianca deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:30 am -
2 stops19h 10m
Sun 11/811:00 pm -
2 stops21h 05m
Deal found 10/21![Avianca logo]()
$838
This LATAM Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/118:40 am -
2 stops17h 52m
Mon 3/297:00 am -
2 stops18h 20m
Deal found 10/22![LATAM Airlines logo]()
$854
This Justfly.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/34:15 pm -
2 stops24h 40m
Tue 2/161:15 pm -
2 stops20h 55m
Deal found 10/20![Avianca logo]()
$858
This Air Canada deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/168:25 am -
2 stops31h 45m
Wed 1/136:30 am -
2 stops24h 45m
Deal found 10/22![Air Canada logo]()
$865
This FlightHub deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/67:30 am -
2 stops33h 25m
Tue 3/211:00 pm -
2 stops35h 10m
Deal found 10/20![Avianca logo]()
$868
This Avianca deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:30 am -
2 stops19h 10m
Sat 11/2811:00 pm -
2 stops21h 05m
Deal found 10/23![Avianca logo]()
$869
Best flights from Santiago to San FranciscoDiscover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
Discover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2011:00 pm -
1 stop24h 47m
Mon 2/88:55 am -
1 stop15h 40m
Deal found 10/21![Delta logo]()
$887
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2110:45 pm -
1 stop31h 13m
Wed 12/3012:45 am -
1 stop27h 05m
Deal found 10/22![United Airlines logo]()
$889
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1111:15 pm -
1 stop19h 08m
Mon 3/2911:50 am -
1 stop16h 15m
Deal found 10/24![American Airlines logo]()
$956
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1411:10 pm -
1 stop24h 51m
Wed 3/246:00 am -
1 stop20h 40m
Deal found 10/20![Delta logo]()
$887
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2610:45 pm -
1 stop18h 34m
Wed 1/1312:30 am -
1 stop27h 20m
Deal found 10/24![United Airlines logo]()
$947
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/159:50 pm -
1 stop26h 11m
Wed 3/244:15 pm -
2 stops18h 45m
Deal found 10/20![Delta logo]()
$887
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/1910:45 pm -
1 stop30h 45m
Wed 2/1011:45 pm -
1 stop28h 05m
Deal found 10/21![United Airlines logo]()
$959
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2311:00 pm -
1 stop26h 10m
Tue 12/296:05 am -
1 stop20h 35m
Deal found 10/22![Delta logo]()
$889
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1810:45 pm -
1 stop16h 00m
Tue 12/295:00 am -
1 stop22h 50m
Deal found 10/22![United Airlines logo]()
$961
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/138:25 pm -
2 stops21h 56m
Fri 8/2011:45 pm -
2 stops28h 10m
Deal found 10/23![Delta logo]()
$1,017
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1410:45 pm -
1 stop26h 25m
Sat 12/2612:45 am -
1 stop27h 05m
Deal found 10/24![United Airlines logo]()
$1,020
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/248:25 pm -
2 stops21h 21m
Thu 1/142:00 pm -
2 stops20h 00m
Deal found 10/24![Delta logo]()
$1,018
Last-minute flights from Santiago to San FranciscoDiscover last-minute flight deals from Santiago to San Francisco. Data last updated October 25, 2026 and is based on user searches.
Discover last-minute flight deals from Santiago to San Francisco. Data last updated October 25, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:30 am -
2 stops19h 10m
Sun 11/811:00 pm -
2 stops21h 05m
Deal found 10/21![Avianca logo]()
$838
This SmartFares deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/14:15 pm -
2 stops48h 40m
Sat 11/71:30 am -
2 stops23h 15m
Deal found 10/22![Avianca logo]()
$862
This Avianca deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:30 am -
2 stops19h 10m
Wed 11/2511:00 pm -
2 stops21h 05m
Deal found 10/24![Avianca logo]()
$873
This Avianca deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:30 am -
2 stops19h 10m
Sat 11/2811:00 pm -
2 stops21h 05m
Deal found 10/23![Avianca logo]()
$869
This Avianca deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:30 am -
2 stops19h 10m
Tue 12/81:15 pm -
2 stops20h 55m
Deal found 10/23![Avianca logo]()
$800
This Avianca deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:30 am -
2 stops19h 10m
Sun 1/311:15 pm -
2 stops20h 55m
Deal found 10/24![Avianca logo]()
$819
This Avianca deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:30 am -
2 stops19h 10m
Wed 12/21:15 pm -
2 stops20h 55m
Deal found 10/20![Avianca logo]()
$828
This Avianca deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:30 am -
2 stops19h 10m
Thu 1/141:15 pm -
2 stops20h 55m
Deal found 10/24![Avianca logo]()
$888
One-way flights from Santiago to San FranciscoSearch for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
Search for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
This Mytrip deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:00 am -
3 stops34h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Multiple Airlines logo]()
$425
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/812:15 pm -
3 stops39h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$431
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1112:15 pm -
3 stops39h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$434
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:00 am -
3 stops44h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$442
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/94:15 pm -
3 stops35h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$443
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:35 pm -
3 stops52h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Multiple Airlines logo]()
$444
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1212:20 pm -
3 stops49h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Multiple Airlines logo]()
$446
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1612:15 pm -
3 stops34h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$448
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/912:20 pm -
3 stops49h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$450
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1112:20 pm -
3 stops49h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Multiple Airlines logo]()
$453
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1911:10 pm -
2 stops51h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/24![Multiple Airlines logo]()
$454
Find flight deals from Santiago to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $800 (Avianca) |
One-way from | $425 (Mytrip) |
Popular in | October |
Cheapest in | February |
Average price | $863 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Wed 12/9
11:10 pm-8:30 am
3 stops38h 20m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$465
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Wed 12/9
7:30 am-9:40 pm
2 stops19h 10m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$477
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Thu 11/19
12:15 pm-9:58 am
3 stops50h 43m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$492
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Sat 1/30
7:30 am-11:55 am
2 stops33h 25m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$585
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Wed 11/11
11:25 pm-11:38 am
1 stop17h 13m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$693
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Sun 1/17
7:40 am-9:22 pm
2 stops18h 42m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$700
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Mon 1/18
10:45 pm-10:30 pm
1 stop28h 45m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$700
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Fri 1/15
7:40 am-9:22 pm
2 stops18h 42m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$700
Quickest round-trip
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Thu 11/12
10:45 pm-9:50 am
1 stop16h 05m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$700
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Sat 1/16
8:40 am-9:22 pm
2 stops17h 42m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$700
Showing 1-10 of 22 resultsSorted by cheapest first
Compare providers for flights from Santiago to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to San Francisco in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*2 stars |
- Most accurate provider: When it comes to deals on Santiago-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santiago-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santiago to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.
SCL-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santiago to San Francisco
How far ahead should I book a flight from Santiago to San Francisco?
The price you pay for your flight from Santiago to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 86 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Santiago to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $616). Flying from Santiago to San Francisco in October is currently the most expensive (average of $863). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Santiago to San Francisco?
Airfare is typical for this route at the moment.
Santiago to San Francisco flights typically cost between $640 and $1,020 in November.The cheapest round-trip price found within the last 5 days was $800 on Avianca (Nov 23-Dec 8).
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated October 25, 2026.
Peruse reviews from past customers who have flown with Delta,Copa Airlines, andLATAM Airlines from Santiago to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Entertainment
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Food
7.2
Entertainment
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Food
7.2
Entertainment
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Food
7.2
Entertainment
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Food
7.2
Entertainment
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Food
7.2
Entertainment
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Santiago to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Hayward
San Bruno
Emeryville
Newark
Burlingame
Roseville
Redwood City
Rancho Cordova
Cupertino
Fairfield
San Ramon
Manteca
San Carlos
Vallejo
Turlock
Davis
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Santiago and San Francisco flights
Browse other Santiago and San Francisco flight options. Last updated on October 25, 2026.
Other flights from Santiago
Browse through other flights departing from Santiago. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
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Check out other popular destinations found by fellow travelers in 2026
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Top 6 airlines flying from Santiago to San Francisco
Discover the top 6 airlines that operate flights from Santiago to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$311 | Average$757 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$494 | Average$667 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$515 | Average$920 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$531 | Average$735 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$542 | Average$638 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$571 | Average$720 | FlexibilityNo cancel fee | On-time69% |