$359+ Cheap flights from Santiago (SCL) to San Francisco (SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/1. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — SFO
Nov 9 — Nov 161
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santiago to San Francisco
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Cheapest flights from Santiago to San FranciscoExplore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 10, 2026.
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 10, 2026.
This LATAM Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1011:55 pm -
1 stop19h 09m
Sun 3/1411:05 am -
1 stop14h 30m
Deal found 10/5![LATAM Airlines logo]()
$664
This LATAM Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/49:55 pm -
2 stops18h 01m
Tue 11/106:00 am -
2 stops18h 05m
Deal found 10/5![LATAM Airlines logo]()
$669
This LATAM Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/118:40 am -
2 stops17h 52m
Mon 3/2911:05 am -
1 stop14h 30m
Deal found 10/4![LATAM Airlines logo]()
$670
This LATAM Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1911:55 pm -
1 stop15h 54m
Thu 11/267:05 am -
1 stop17h 30m
Deal found 10/5![LATAM Airlines logo]()
$672
This FlightHub deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/611:55 pm -
1 stop19h 09m
Tue 3/27:30 am -
2 stops17h 30m
Deal found 10/5![LATAM Airlines logo]()
$675
This LATAM Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/279:55 pm -
2 stops17h 10m
Tue 11/177:05 am -
2 stops17h 00m
Deal found 10/5![LATAM Airlines logo]()
$676
This LATAM Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/59:55 pm -
2 stops18h 01m
Thu 11/126:00 am -
1 stop20h 40m
Deal found 10/5![LATAM Airlines logo]()
$678
This Avianca deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:40 am -
2 stops18h 55m
Tue 10/2011:55 pm -
2 stops20h 25m
Deal found 10/5![Avianca logo]()
$683
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/39:55 pm -
2 stops18h 06m
Mon 11/98:00 am -
1 stop18h 40m
Deal found 10/5![Delta logo]()
$684
This Justfly.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/311:55 pm -
1 stop19h 09m
Tue 2/166:00 am -
1 stop20h 40m
Deal found 10/7![LATAM Airlines logo]()
$686
This Copa Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1112:20 pm -
1 stop34h 05m
Mon 3/297:55 pm -
1 stop24h 09m
Deal found 10/7![Copa Airlines logo]()
$688
Best flights from Santiago to San FranciscoDiscover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 10, 2026.
Discover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 10, 2026.
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/811:10 pm -
1 stop24h 47m
Thu 11/1211:51 am -
1 stop14h 49m
Deal found 10/5![Delta logo]()
$684
This Copa Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1112:20 pm -
1 stop34h 05m
Mon 3/297:55 pm -
1 stop24h 09m
Deal found 10/7![Copa Airlines logo]()
$688
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/510:45 pm -
1 stop25h 00m
Mon 11/910:53 am -
1 stop16h 57m
Deal found 10/5![United Airlines logo]()
$701
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2011:10 pm -
1 stop24h 47m
Fri 11/276:00 am -
1 stop20h 40m
Deal found 10/6![Delta logo]()
$692
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2411:55 pm -
1 stop16h 59m
Tue 1/56:00 am -
1 stop20h 40m
Deal found 10/5![Delta logo]()
$692
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/311:10 pm -
1 stop24h 46m
Tue 2/167:00 am -
2 stops19h 40m
Deal found 10/5![Delta logo]()
$692
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/211:55 pm -
1 stop21h 27m
Tue 11/106:00 am -
1 stop20h 40m
Deal found 10/6![Delta logo]()
$701
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:10 pm -
1 stop24h 56m
Mon 11/98:00 am -
1 stop18h 40m
Deal found 10/6![Delta logo]()
$701
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1111:10 pm -
1 stop18h 30m
Tue 1/197:30 am -
1 stop18h 10m
Deal found 10/6![Delta logo]()
$705
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1111:10 pm -
1 stop18h 30m
Wed 1/207:30 am -
1 stop18h 10m
Deal found 10/6![Delta logo]()
$705
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1111:10 pm -
1 stop18h 30m
Mon 1/1811:05 am -
1 stop13h 30m
Deal found 10/6![Delta logo]()
$705
Last-minute flights from Santiago to San FranciscoDiscover last-minute flight deals from Santiago to San Francisco. Data last updated October 10, 2026 and is based on user searches.
Discover last-minute flight deals from Santiago to San Francisco. Data last updated October 10, 2026 and is based on user searches.
This LATAM Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/279:55 pm -
2 stops17h 10m
Tue 11/177:05 am -
2 stops17h 00m
Deal found 10/5![LATAM Airlines logo]()
$676
This FlightHub deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:10 pm -
1 stop21h 52m
Tue 11/106:00 am -
2 stops18h 05m
Deal found 10/7![LATAM Airlines logo]()
$690
This LATAM Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:10 pm -
1 stop17h 32m
Tue 11/247:05 am -
2 stops17h 00m
Deal found 10/5![LATAM Airlines logo]()
$683
This Copa Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:07 am -
1 stop23h 05m
Sun 11/157:36 pm -
1 stop23h 00m
Deal found 10/7![Copa Airlines logo]()
$688
This Delta deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/111:10 pm -
1 stop25h 56m
Sun 11/1511:59 pm -
2 stops24h 36m
Deal found 10/7![Delta logo]()
$692
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/39:55 pm -
2 stops18h 06m
Mon 11/98:00 am -
1 stop18h 40m
Deal found 10/5![Delta logo]()
$684
This LATAM Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/49:55 pm -
2 stops18h 01m
Tue 11/106:00 am -
2 stops18h 05m
Deal found 10/5![LATAM Airlines logo]()
$669
This LATAM Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/59:55 pm -
2 stops18h 01m
Thu 11/126:00 am -
1 stop20h 40m
Deal found 10/5![LATAM Airlines logo]()
$678
This Justfly.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/179:45 am -
2 stops19h 13m
Tue 12/87:05 am -
2 stops17h 00m
Deal found 10/7![LATAM Airlines logo]()
$689
This LATAM Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1911:55 pm -
1 stop15h 54m
Thu 11/267:05 am -
1 stop17h 30m
Deal found 10/5![LATAM Airlines logo]()
$672
This LATAM Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2011:55 pm -
1 stop18h 57m
Mon 11/307:05 am -
1 stop17h 30m
Deal found 10/5![LATAM Airlines logo]()
$664
One-way flights from Santiago to San FranciscoSearch for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 10, 2026.
Search for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/18:35 pm -
3 stops41h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Multiple Airlines logo]()
$359
This Kiwi.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/98:35 pm -
3 stops41h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Multiple Airlines logo]()
$380
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:35 pm -
3 stops43h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![Multiple Airlines logo]()
$399
This Kiwi.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/108:35 pm -
3 stops47h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Multiple Airlines logo]()
$402
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/201:34 pm -
3 stops36h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![Multiple Airlines logo]()
$404
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/218:33 pm -
3 stops29h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Multiple Airlines logo]()
$407
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:33 pm -
3 stops42h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![Multiple Airlines logo]()
$409
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/78:35 pm -
3 stops50h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Multiple Airlines logo]()
$422
This Kiwi.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/168:35 pm -
3 stops43h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Multiple Airlines logo]()
$423
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:07 am -
2 stops20h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Multiple Airlines logo]()
$425
Find flight deals from Santiago to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $664 (LATAM Airlines) |
One-way from | $359 (Kiwi.com) |
Popular in | June |
Cheapest in | November |
Average price | $712 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 10, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Fri 3/12
7:30 am-9:40 pm
2 stops19h 10m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$459
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Wed 10/21
7:40 am-10:35 pm
2 stops18h 55m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$470
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Wed 11/11
11:25 pm-11:38 am
1 stop17h 13m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$595
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Sat 12/26
10:45 pm-6:45 pm
1 stop25h 00m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$651
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Mon 12/28
8:25 pm-11:54 am
2 stops20h 29m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$651
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Mon 12/28
10:45 pm-12:58 am
1 stop31h 13m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$651
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Mon 4/5
11:25 pm-1:29 pm
1 stop17h 04m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$658
Quickest round-trip
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Sat 12/19
11:55 pm-11:54 am
1 stop16h 59m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$658
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Sat 11/14
11:55 pm-1:52 pm
1 stop18h 57m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$665
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Sun 12/27
10:45 pm-12:58 am
1 stop31h 13m
San Francisco
Wed 12/31
12:00 am-5:00 am
Nonstop0h 00m
$680
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Santiago to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to San Francisco in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*2 stars |
- Most accurate provider: When it comes to deals on Santiago-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santiago-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santiago to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.
SCL-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santiago to San Francisco
How far ahead should I book a flight from Santiago to San Francisco?
The price you pay for your flight from Santiago to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 6 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Santiago to San Francisco?
Currently, November is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $605). Flying from Santiago to San Francisco in June is currently the most expensive (average of $787). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Santiago to San Francisco?
Airfare is typical for this route at the moment.
Santiago to San Francisco flights typically cost between $578 and $981 in December.The cheapest round-trip price found within the last 5 days was $664 on LATAM Airlines (Dec 10-Mar 14).
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated October 10, 2026.
Peruse reviews from past customers who have flown with Delta,Copa Airlines, andLATAM Airlines from Santiago to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Boarding
8.1
Overall
7.8
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Food
7.2
Boarding
8.1
Overall
7.8
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Food
7.2
Boarding
8.1
Overall
7.8
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Food
7.2
Boarding
8.1
Overall
7.8
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Food
7.2
Boarding
8.1
Overall
7.8
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Food
7.2
Boarding
8.1
Overall
7.8
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Santiago to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
San Bruno
Emeryville
Hayward
Burlingame
Rancho Cordova
Roseville
Redwood City
Cupertino
Newark
Fairfield
San Ramon
Manteca
Vallejo
San Carlos
Turlock
Davis
Browse thousands of different options on Cheapflights for your next trip
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Complete your trip
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Search flights from Santiago to San Francisco by cabin class
Find flights from Santiago to San Francisco, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Santiago and San Francisco flights
Browse other Santiago and San Francisco flight options. Last updated on October 10, 2026.
Other flights from Santiago
Browse through other flights departing from Santiago. Flights are based on user searches made on Cheapflights and were last updated on October 10, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 10, 2026.
Top 6 airlines flying from Santiago to San Francisco
Discover the top 6 airlines that operate flights from Santiago to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$311 | Average$757 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$448 | Average$635 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$481 | Average$843 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$494 | Average$667 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$531 | Average$735 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$571 | Average$720 | FlexibilityNo cancel fee | On-time69% |