$362+ Cheap flights from Santiago (SCL) to San Francisco (SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/17. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — SFO
Oct 1 — Oct 81
Round-trip
1 adult, Economy
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Find cheap flights from Santiago to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santiago to San Francisco
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Cheapest flights from Santiago to San FranciscoExplore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 1, 2026.
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 1, 2026.
This FlightHub deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1611:55 pm -
1 stop18h 57m
Tue 11/247:05 am -
1 stop17h 30m
Deal found 8/31![LATAM Airlines logo]()
$524
This eDestinos deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/119:55 pm -
2 stops17h 59m
Mon 3/297:00 am -
2 stops19h 25m
Deal found 8/30![LATAM Airlines logo]()
$530
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1411:10 pm -
2 stops23h 15m
Sat 1/97:30 am -
1 stop19h 10m
Deal found 8/31![Delta logo]()
$532
This LATAM Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:10 pm -
1 stop24h 56m
Wed 11/46:00 am -
2 stops18h 35m
Deal found 8/31![LATAM Airlines logo]()
$534
This Delta deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/119:50 pm -
1 stop26h 04m
Mon 3/2910:45 pm -
1 stop27h 05m
Deal found 8/30![Delta logo]()
$536
This Justfly.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2111:55 pm -
2 stops19h 54m
Sun 9/2711:58 am -
1 stop13h 37m
Deal found 8/31![LATAM Airlines logo]()
$539
This LATAM Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:10 pm -
1 stop24h 56m
Sat 11/76:00 am -
2 stops20h 30m
Deal found 8/30![LATAM Airlines logo]()
$541
This LATAM Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:30 pm -
2 stops32h 25m
Wed 10/2811:30 pm -
2 stops28h 00m
Deal found 8/31![LATAM Airlines logo]()
$542
This LATAM Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/178:40 am -
2 stops17h 46m
Tue 1/56:00 am -
1 stop20h 40m
Deal found 8/31![LATAM Airlines logo]()
$545
This LATAM Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1811:55 pm -
2 stops38h 39m
Sun 10/2511:30 pm -
2 stops27h 30m
Deal found 8/31![LATAM Airlines logo]()
$550
This Travelocity deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3011:55 pm -
1 stop15h 29m
Wed 10/74:51 pm -
1 stop32h 44m
Deal found 8/31![Multiple Airlines logo]()
$562
This SmartFares deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:30 am -
2 stops19h 54m
Fri 12/48:01 am -
1 stop18h 39m
Deal found 8/31![LATAM Airlines logo]()
$563
Best flights from Santiago to San FranciscoDiscover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 1, 2026.
Discover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 1, 2026.
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1911:55 pm -
1 stop17h 30m
Sun 9/277:20 am -
1 stop18h 15m
Deal found 8/31![Delta logo]()
$532
This Copa Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:15 am -
1 stop24h 25m
Wed 11/47:36 pm -
1 stop29h 10m
Deal found 8/27![Copa Airlines logo]()
$713
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2710:45 pm -
1 stop37h 42m
Sun 1/1712:15 am -
1 stop27h 35m
Deal found 8/31![United Airlines logo]()
$754
This LATAM Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/148:25 pm -
2 stops22h 04m
Sat 2/201:35 pm -
1 stop36h 25m
Deal found 8/28![Multiple Airlines logo]()
$786
This LATAM Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/284:50 am -
2 stops24h 07m
Sat 2/208:55 am -
1 stop15h 40m
Deal found 8/31![LATAM Airlines logo]()
$838
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/149:55 pm -
2 stops22h 45m
Sun 1/36:00 am -
1 stop19h 40m
Deal found 8/27![Delta logo]()
$714
This Copa Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/293:57 am -
1 stop23h 43m
Fri 11/612:33 am -
1 stop18h 46m
Deal found 8/28![Copa Airlines logo]()
$763
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2011:55 pm -
1 stop17h 30m
Sat 9/266:00 am -
1 stop22h 15m
Deal found 8/31![Delta logo]()
$715
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2611:55 pm -
1 stop20h 40m
Sun 12/65:15 pm -
2 stops19h 25m
Deal found 8/27![Delta logo]()
$716
This Delta deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:10 pm -
1 stop20h 49m
Sat 11/76:00 am -
2 stops20h 15m
Deal found 8/30![Delta logo]()
$716
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2711:00 pm -
1 stop26h 17m
Mon 1/186:15 am -
2 stops18h 20m
Deal found 8/31![Delta logo]()
$836
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1911:55 pm -
1 stop23h 41m
Thu 10/17:20 am -
1 stop18h 15m
Deal found 8/31![Delta logo]()
$836
Last-minute flights from Santiago to San FranciscoDiscover last-minute flight deals from Santiago to San Francisco. Data last updated September 1, 2026 and is based on user searches.
Discover last-minute flight deals from Santiago to San Francisco. Data last updated September 1, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1911:55 pm -
1 stop17h 30m
Sun 9/277:20 am -
1 stop18h 15m
Deal found 8/31![Delta logo]()
$532
This LATAM Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1911:55 pm -
1 stop14h 58m
Tue 9/296:00 am -
2 stops19h 40m
Deal found 8/31![LATAM Airlines logo]()
$545
This Justfly.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2111:55 pm -
2 stops19h 54m
Sun 9/2711:58 am -
1 stop13h 37m
Deal found 8/31![LATAM Airlines logo]()
$539
This FlightHub deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2111:55 pm -
2 stops19h 54m
Sun 9/272:50 pm -
2 stops35h 55m
Deal found 8/31![Multiple Airlines logo]()
$664
This LATAM Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/229:30 am -
1 stop31h 50m
Thu 10/87:10 am -
1 stop18h 25m
Deal found 8/30![Multiple Airlines logo]()
$600
This Travelocity deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/229:30 am -
2 stops27h 10m
Tue 9/296:00 am -
2 stops20h 45m
Deal found 8/31![Multiple Airlines logo]()
$636
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/288:40 pm -
2 stops22h 12m
Mon 10/56:00 am -
2 stops19h 35m
Deal found 8/31![Delta logo]()
$536
This LATAM Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/288:40 pm -
1 stop27h 18m
Mon 10/59:55 pm -
2 stops29h 05m
Deal found 8/31![LATAM Airlines logo]()
$605
This Travelocity deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3011:55 pm -
1 stop15h 29m
Wed 10/74:51 pm -
1 stop32h 44m
Deal found 8/31![Multiple Airlines logo]()
$562
One-way flights from Santiago to San FranciscoSearch for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 1, 2026.
Search for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 1, 2026.
This Avianca deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/177:30 am -
2 stops19h 10m
Deal found 8/30![Avianca logo]()
$362
This Avianca deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/177:30 am -
2 stops19h 10m
Deal found 8/28![Avianca logo]()
$364
This Avianca deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:30 am -
2 stops19h 10m
Deal found 8/30![Avianca logo]()
$366
This Avianca deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/227:30 am -
2 stops19h 10m
Deal found 8/30![Avianca logo]()
$369
This SmartFares deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/144:20 pm -
2 stops24h 30m
Deal found 8/28![Avianca logo]()
$378
This FlightHub deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/192:10 am -
2 stops38h 45m
Deal found 8/28![Avianca logo]()
$391
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/258:33 pm -
3 stops42h 44m
Deal found 8/31![Multiple Airlines logo]()
$392
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:33 pm -
3 stops42h 44m
Deal found 8/31![Multiple Airlines logo]()
$400
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/248:33 pm -
3 stops55h 42m
Deal found 8/31![Multiple Airlines logo]()
$401
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:00 am -
3 stops34h 17m
Deal found 8/31![Multiple Airlines logo]()
$403
This Despegar deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Despegar is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:30 am -
2 stops25h 05m
Deal found 8/31![Avianca logo]()
$406
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:00 am -
3 stops34h 17m
Deal found 8/30![Multiple Airlines logo]()
$407
Find flight deals from Santiago to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $524 (FlightHub) |
One-way from | $362 (Avianca) |
Popular in | June |
Cheapest in | November |
Average price | $744 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 1, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Sat 9/19
11:55 pm-1:25 pm
1 stop17h 30m
San Francisco
Sun 9/27
7:20 am-5:35 am
1 stop18h 15m
$532
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Wed 10/21
3:15 am-11:40 pm
1 stop24h 25m
San Francisco
Wed 11/4
7:36 pm-5:46 am
1 stop29h 10m
$713
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Mon 12/14
9:55 pm-3:40 pm
2 stops22h 45m
San Francisco
Sun 1/3
6:00 am-6:40 am
1 stop19h 40m
$714
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Sun 9/20
11:55 pm-1:25 pm
1 stop17h 30m
San Francisco
Sat 9/26
6:00 am-8:15 am
1 stop22h 15m
$715
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Thu 11/26
11:55 pm-3:35 pm
1 stop20h 40m
San Francisco
Sun 12/6
5:15 pm-5:40 pm
2 stops19h 25m
$716
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Fri 10/30
11:10 pm-3:59 pm
1 stop20h 49m
San Francisco
Sat 11/7
6:00 am-7:15 am
2 stops20h 15m
$716
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Sun 12/27
10:45 pm-7:27 am
1 stop37h 42m
San Francisco
Sun 1/17
12:15 am-8:50 am
1 stop27h 35m
$754
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Thu 10/29
3:57 am-11:40 pm
1 stop23h 43m
San Francisco
Fri 11/6
12:33 am-12:19 am
1 stop18h 46m
$763
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Sun 2/14
8:25 pm-1:29 pm
2 stops22h 04m
San Francisco
Sat 2/20
1:35 pm-7:00 am
1 stop36h 25m
$786
SantiagoSan Francisco
SCL Santiago Arturo Merino Benitez - SFO San Francisco
SCLSFO
Santiago Arturo Merino Benitez
Sun 12/27
11:00 pm-8:17 pm
1 stop26h 17m
San Francisco
Mon 1/18
6:15 am-5:35 am
2 stops18h 20m
$836
Showing 1-10 of 24 resultsSorted by cheapest first
Compare providers for flights from Santiago to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to San Francisco in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*2 stars |
- Most accurate provider: When it comes to deals on Santiago-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santiago-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santiago to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.
SCL-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santiago to San Francisco
How far ahead should I book a flight from Santiago to San Francisco?
The price you pay for your flight from Santiago to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 6 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Santiago to San Francisco?
Currently, November is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $588). Flying from Santiago to San Francisco in June is currently the most expensive (average of $787). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Santiago to San Francisco?
Airfare is below average for this route at the moment.
Santiago to San Francisco flights typically cost between $630 and $903 in November.The cheapest round-trip price found within the last 5 days was $524 on LATAM Airlines (Nov 16-Nov 24).
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated September 1, 2026.
Peruse reviews from past customers who have flown with Delta,Copa Airlines, andLATAM Airlines from Santiago to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Food
7.2
Entertainment
7.8
Overall
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Comfort
7.8
Food
7.2
Entertainment
7.8
Overall
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Comfort
7.8
Food
7.2
Entertainment
7.8
Overall
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Comfort
7.8
Food
7.2
Entertainment
7.8
Overall
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Comfort
7.8
Food
7.2
Entertainment
7.8
Overall
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Comfort
7.8
Food
7.2
Entertainment
7.8
Overall
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Santiago to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Emeryville
San Bruno
Burlingame
Rancho Cordova
Roseville
Fairfield
Vallejo
Cupertino
Newark
Hayward
San Ramon
Redwood City
Manteca
San Carlos
Turlock
Davis
Browse thousands of different options on Cheapflights for your next trip
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Complete your trip
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Search flights from Santiago to San Francisco by cabin class
Find flights from Santiago to San Francisco, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Santiago and San Francisco flights
Browse other Santiago and San Francisco flight options. Last updated on September 1, 2026.
Other flights from Santiago
Browse through other flights departing from Santiago. Flights are based on user searches made on Cheapflights and were last updated on September 1, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 1, 2026.
Top 6 airlines flying from Santiago to San Francisco
Discover the top 6 airlines that operate flights from Santiago to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$311 | Average$757 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$448 | Average$635 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$481 | Average$754 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$494 | Average$667 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$559 | Average$735 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$571 | Average$720 | FlexibilityNo cancel fee | On-time69% |