$317+ Cheap flights from Santiago (SCL) to San Francisco (SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/26. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — SFO
Jun 6 — Jun 131
Round-trip
1 adult, Economy
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Find cheap flights from Santiago to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santiago to San Francisco
Cheapest
Best
Last-minute
One-way
Cheapest flights from Santiago to San FranciscoExplore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 7, 2026.
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 7, 2026.
This Copa Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:27 am
SCL
- SFO
1 stop24h 13m
Copa Airlines
Sun 9/61:12 am
SFO
- SCL
1 stop15h 07m
Copa Airlines
Deal found 5/2![Copa Airlines logo]()
$619
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Fri 8/282:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 5/6![Avianca logo]()
$621
This FlightHub deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1112:40 am
SCL
- SFO
2 stops21h 59m
LATAM Airlines
Tue 8/189:30 am
SFO
- SCL
1 stop17h 05m
LATAM Airlines
Deal found 5/4![LATAM Airlines logo]()
$624
This eDestinos deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/1411:25 pm
SCL
- SFO
1 stop19h 28m
LATAM Airlines
Wed 6/247:00 am
SFO
- SCL
1 stop19h 35m
LATAM Airlines
Deal found 5/6![LATAM Airlines logo]()
$631
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:40 am
SCL
- SFO
2 stops20h 15m
Avianca
Thu 8/202:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 5/6![Avianca logo]()
$633
This eDestinos deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2711:25 pm
SCL
- SFO
1 stop19h 25m
LATAM Airlines
Tue 9/296:00 am
SFO
- SCL
2 stops19h 35m
LATAM Airlines
Deal found 5/6![LATAM Airlines logo]()
$635
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Thu 8/2011:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 5/6![Avianca logo]()
$636
Best flights from Santiago to San FranciscoDiscover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 7, 2026.
Discover carefully curated flight deals from Santiago to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 7, 2026.
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:40 am
SCL
- SFO
2 stops20h 15m
Avianca
Sat 8/1511:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 5/6![Avianca logo]()
$633
This Copa Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/111:17 am
SCL
- SFO
1 stop15h 23m
Copa Airlines
Wed 7/291:12 am
SFO
- SCL
1 stop22h 48m
Copa Airlines
Deal found 5/2![Copa Airlines logo]()
$642
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/1411:25 pm
SCL
- SFO
1 stop19h 28m
Delta
Sun 6/2111:45 am
SFO
- SCL
1 stop14h 50m
Delta
Deal found 5/2![Delta logo]()
$651
This Copa Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/211:17 am
SCL
- SFO
1 stop15h 23m
Copa Airlines
Mon 6/81:12 am
SFO
- SCL
1 stop15h 11m
Copa Airlines
Deal found 5/5![Copa Airlines logo]()
$648
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/511:00 pm
SCL
- SFO
2 stops22h 11m
Delta
Tue 10/136:00 am
SFO
- SCL
2 stops19h 35m
Delta
Deal found 5/6![Delta logo]()
$651
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/28:40 pm
SCL
- SFO
2 stops21h 17m
Delta
Tue 6/96:00 am
SFO
- SCL
2 stops21h 55m
Delta
Deal found 5/5![Delta logo]()
$651
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2810:55 pm
SCL
- SFO
1 stop19h 02m
Delta
Thu 8/209:30 am
SFO
- SCL
1 stop17h 05m
Delta
Deal found 5/4![Delta logo]()
$651
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/611:00 pm
SCL
- SFO
2 stops22h 11m
Delta
Mon 10/127:00 am
SFO
- SCL
2 stops18h 35m
Delta
Deal found 5/6![Delta logo]()
$651
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2511:00 pm
SCL
- SFO
2 stops19h 42m
Delta
Mon 9/76:00 am
SFO
- SCL
1 stop22h 15m
Delta
Deal found 5/3![Delta logo]()
$651
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/118:40 pm
SCL
- SFO
1 stop26h 25m
Delta
Tue 7/144:00 pm
SFO
- SCL
2 stops24h 45m
Delta
Deal found 5/2![Delta logo]()
$654
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1711:00 pm
SCL
- SFO
2 stops19h 42m
Delta
Tue 8/254:05 pm
SFO
- SCL
2 stops24h 40m
Delta
Deal found 5/4![Delta logo]()
$655
Last-minute flights from Santiago to San FranciscoDiscover last-minute flight deals from Santiago to San Francisco. Data last updated May 7, 2026 and is based on user searches.
Discover last-minute flight deals from Santiago to San Francisco. Data last updated May 7, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Thu 8/2011:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 5/6![Avianca logo]()
$636
This Avianca deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Thu 5/282:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 5/5![Avianca logo]()
$646
This Avianca deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Sun 5/1011:55 pm
SFO
- SCL
2 stops20h 25m
Avianca
Deal found 5/5![Avianca logo]()
$648
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:40 am
SCL
- SFO
2 stops20h 15m
Avianca
Thu 8/202:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 5/6![Avianca logo]()
$633
This Copa Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/111:17 am
SCL
- SFO
1 stop15h 23m
Copa Airlines
Wed 7/291:12 am
SFO
- SCL
1 stop22h 48m
Copa Airlines
Deal found 5/2![Copa Airlines logo]()
$642
This Avianca deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:40 am
SCL
- SFO
2 stops20h 15m
Avianca
Wed 9/22:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Deal found 5/4![Avianca logo]()
$624
This Rumbo deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Rumbo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/611:25 pm
SCL
- SFO
1 stop17h 06m
LATAM Airlines
Sun 6/2111:45 am
SFO
- SCL
1 stop14h 50m
LATAM Airlines
Deal found 5/2![LATAM Airlines logo]()
$643
This eDestinos deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/1411:25 pm
SCL
- SFO
1 stop19h 28m
LATAM Airlines
Wed 6/247:00 am
SFO
- SCL
1 stop19h 35m
LATAM Airlines
Deal found 5/6![LATAM Airlines logo]()
$631
One-way flights from Santiago to San FranciscoSearch for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 7, 2026.
Search for one-way flight options from Santiago to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 7, 2026.
This Avianca deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Deal found 5/5![Avianca logo]()
$317
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Deal found 5/6![Avianca logo]()
$319
This Cheapflightsfares deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/203:20 pm
SCL
- SFO
2 stops35h 35m
Avianca
Deal found 5/5![Avianca logo]()
$320
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Deal found 5/6![Avianca logo]()
$322
This Avianca deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:40 am
SCL
- SFO
2 stops20h 15m
Avianca
Deal found 5/2![Avianca logo]()
$325
This Avianca deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Deal found 5/2![Avianca logo]()
$330
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Deal found 5/6![Avianca logo]()
$331
This SmartFares deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/173:20 pm
SCL
- SFO
2 stops35h 35m
Avianca
Deal found 5/6![Avianca logo]()
$333
This SmartFares deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/243:20 pm
SCL
- SFO
2 stops24h 30m
Avianca
Deal found 5/2![Avianca logo]()
$336
This Justfly.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/313:20 pm
SCL
- SFO
2 stops34h 15m
Avianca
Deal found 5/4![Avianca logo]()
$346
Find flight deals from Santiago to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $619 (Copa Airlines) |
One-way from | $317 (Avianca) |
Popular in | June |
Cheapest in | October |
Average price | $670 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 7, 2026.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Sat 8/1
6:40 am-11:55 pm
2 stops20h 15m
San Francisco
Sat 8/15
11:55 pm-11:20 pm
2 stops20h 25m
$633
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Mon 6/1
11:17 am-11:40 pm
1 stop15h 23m
San Francisco
Wed 7/29
1:12 am-3:00 am
1 stop22h 48m
$642
Quickest round-trip
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Tue 6/2
11:17 am-11:40 pm
1 stop15h 23m
San Francisco
Mon 6/8
1:12 am-7:23 pm
1 stop15h 11m
$648
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Sun 6/14
11:25 pm-3:53 pm
1 stop19h 28m
San Francisco
Sun 6/21
11:45 am-5:35 am
1 stop14h 50m
$651
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Mon 10/5
11:00 pm-5:11 pm
2 stops22h 11m
San Francisco
Tue 10/13
6:00 am-5:35 am
2 stops19h 35m
$651
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Tue 6/2
8:40 pm-2:57 pm
2 stops21h 17m
San Francisco
Tue 6/9
6:00 am-6:55 am
2 stops21h 55m
$651
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Thu 5/28
10:55 pm-2:57 pm
1 stop19h 02m
San Francisco
Thu 8/20
9:30 am-5:35 am
1 stop17h 05m
$651
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Tue 10/6
11:00 pm-5:11 pm
2 stops22h 11m
San Francisco
Mon 10/12
7:00 am-5:35 am
2 stops18h 35m
$651
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Tue 8/25
11:00 pm-3:42 pm
2 stops19h 42m
San Francisco
Mon 9/7
6:00 am-8:15 am
1 stop22h 15m
$651
SantiagoSan Francisco
SCL - SFO
SCLSFO
Santiago Arturo Merino Benitez
Sat 7/11
8:40 pm-8:05 pm
1 stop26h 25m
San Francisco
Tue 7/14
4:00 pm-7:45 pm
2 stops24h 45m
$654
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Santiago to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to San Francisco in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Santiago-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santiago-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santiago to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.
SCL-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santiago to San Francisco
How far ahead should I book a flight from Santiago to San Francisco?
The price you pay for your flight from Santiago to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 39 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Santiago to San Francisco?
Currently, October is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $555). Flying from Santiago to San Francisco in June is currently the most expensive (average of $778). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Santiago to San Francisco?
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated May 7, 2026.
Peruse reviews from past customers who have flown with Delta,Copa Airlines, andLATAM Airlines from Santiago to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Comfort
7.9
Food
7.2
Boarding
8.1
Overall
7.9
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Comfort
7.9
Food
7.2
Boarding
8.1
Overall
7.9
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Comfort
7.9
Food
7.2
Boarding
8.1
Overall
7.9
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Comfort
7.9
Food
7.2
Boarding
8.1
Overall
7.9
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Comfort
7.9
Food
7.2
Boarding
8.1
Overall
7.9
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Entertainment
7.8
Comfort
7.9
Food
7.2
Boarding
8.1
Overall
7.9
Crew
8.5
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Santiago to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
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Santiago and San Francisco flights
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Top 6 airlines flying from Santiago to San Francisco
Discover the top 6 airlines that operate flights from Santiago to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$433 | Average$675 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$481 | Average$624 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$504 | Average$663 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$511 | Average$632 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$554 | Average$744 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$571 | Average$710 | FlexibilityNo cancel fee | On-time69% |