$143+ Cheap flights from Indianapolis to San Francisco (IND - SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/23. Fares are subject to change and may not be available on all flights or dates of travel.
IND — SFO
Oct 21 — Oct 281
Round-trip
1 adult, Economy
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Find cheap flights from Indianapolis to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Indianapolis to San Francisco are usually found in April or May, booked 66 days in advance, depart on a Friday or Thursday and return on a Saturday
Cheap flight deals from Indianapolis to San Francisco
Cheapest
Best
Last-minute
One-way
Cheapest flights from Indianapolis to San FranciscoExplore the most affordable flight options available from Indianapolis to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 21, 2026.
Explore the most affordable flight options available from Indianapolis to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 21, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1512:56 pm -
1 stop14h 19m
Mon 10/197:13 pm -
1 stop17h 00m
Deal found 9/19![Frontier logo]()
$334
This Cheapflightsfares deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/910:33 am -
1 stop10h 22m
Wed 10/146:00 am -
1 stop6h 13m
Deal found 9/20![Frontier logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1512:56 pm -
1 stop8h 22m
Wed 10/216:00 am -
2 stops10h 04m
Deal found 9/20![Frontier logo]()
$336
This Mytrip deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:59 pm -
2 stops21h 26m
Mon 10/197:25 pm -
2 stops16h 48m
Deal found 9/16![Frontier logo]()
$337
This Frontier deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/174:25 pm -
1 stop11h 16m
Thu 1/76:15 am -
1 stop6h 20m
Deal found 9/18![Frontier logo]()
$338
This Mytrip deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:12 pm -
1 stop11h 02m
Tue 10/1311:59 pm -
2 stops16h 05m
Deal found 9/17![Frontier logo]()
$339
This Cheapflightsfares deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/812:56 pm -
1 stop14h 19m
Tue 10/136:00 am -
1 stop6h 13m
Deal found 9/21![Frontier logo]()
$340
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/193:58 pm -
2 stops21h 00m
Wed 12/27:26 pm -
1 stop17h 18m
Deal found 9/19![Frontier logo]()
$341
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:05 am -
2 stops8h 15m
Mon 11/27:00 am -
2 stops9h 55m
Deal found 9/16![Southwest logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:16 pm -
1 stop8h 10m
Wed 12/27:26 pm -
1 stop17h 18m
Deal found 9/19![Multiple Airlines logo]()
$343
This Cheapflightsfares deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/84:08 pm -
1 stop11h 07m
Mon 10/127:13 pm -
1 stop17h 00m
Deal found 9/19![Frontier logo]()
$344
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:25 pm -
1 stop7h 20m
Mon 10/1912:20 pm -
1 stop9h 50m
Deal found 9/16![Southwest logo]()
$345
Best flights from Indianapolis to San FranciscoDiscover carefully curated flight deals from Indianapolis to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 21, 2026.
Discover carefully curated flight deals from Indianapolis to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 21, 2026.
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:11 pm -
1 stop8h 11m
Wed 12/211:48 pm -
1 stop9h 15m
Deal found 9/18![Delta logo]()
$399
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:00 am -
1 stop7h 00m
Fri 11/275:05 am -
1 stop6h 10m
Deal found 9/21![Southwest logo]()
$433
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:04 pm -
1 stop8h 26m
Sat 10/249:47 am -
Nonstop4h 16m
Deal found 9/17![United Airlines logo]()
$452
This Alaska Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:30 am -
2 stops13h 07m
Mon 12/148:20 am -
2 stops11h 43m
Deal found 9/20![Alaska Airlines logo]()
$469
This Alaska Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:16 pm -
2 stops11h 36m
Tue 10/206:07 am -
2 stops13h 52m
Deal found 9/16![Alaska Airlines logo]()
$470
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:00 am -
1 stop7h 44m
Sun 10/2510:53 pm -
Nonstop4h 19m
Deal found 9/16![United Airlines logo]()
$485
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:14 am -
Nonstop5h 01m
Sat 10/319:27 am -
Nonstop4h 17m
Deal found 9/20![United Airlines logo]()
$499
This Alaska Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/111:52 am -
2 stops11h 51m
Fri 10/28:53 pm -
2 stops13h 37m
Deal found 9/17![Alaska Airlines logo]()
$540
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:00 am -
1 stop7h 44m
Sun 10/411:25 pm -
Nonstop4h 30m
Deal found 9/20![United Airlines logo]()
$515
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:14 am -
Nonstop5h 01m
Mon 11/3010:53 pm -
Nonstop4h 19m
Deal found 9/18![United Airlines logo]()
$533
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:14 am -
Nonstop5h 01m
Wed 11/410:42 am -
Nonstop4h 17m
Deal found 9/21![United Airlines logo]()
$534
Last-minute flights from Indianapolis to San FranciscoDiscover last-minute flight deals from Indianapolis to San Francisco. Data last updated September 21, 2026 and is based on user searches.
Discover last-minute flight deals from Indianapolis to San Francisco. Data last updated September 21, 2026 and is based on user searches.
This Mytrip deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:12 pm -
1 stop11h 02m
Tue 10/1311:59 pm -
2 stops16h 05m
Deal found 9/17![Frontier logo]()
$339
This Cheapflightsfares deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/812:56 pm -
1 stop14h 19m
Tue 10/136:00 am -
1 stop6h 13m
Deal found 9/21![Frontier logo]()
$340
This Cheapflightsfares deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/84:08 pm -
1 stop11h 07m
Mon 10/127:13 pm -
1 stop17h 00m
Deal found 9/19![Frontier logo]()
$344
This Cheapflightsfares deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/910:33 am -
1 stop10h 22m
Wed 10/146:00 am -
1 stop6h 13m
Deal found 9/20![Frontier logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:59 pm -
2 stops25h 26m
Sat 10/1712:00 pm -
1 stop21h 01m
Deal found 9/20![Frontier logo]()
$338
This Cheapflightsfares deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1512:56 pm -
1 stop14h 19m
Mon 10/197:13 pm -
1 stop17h 00m
Deal found 9/19![Frontier logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1512:56 pm -
1 stop8h 22m
Wed 10/216:00 am -
2 stops10h 04m
Deal found 9/20![Frontier logo]()
$336
This CheapOair deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1512:56 pm -
1 stop8h 22m
Tue 10/2012:00 pm -
2 stops28h 04m
Deal found 9/18![Frontier logo]()
$343
This Mytrip deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:59 pm -
2 stops21h 26m
Mon 10/197:25 pm -
2 stops16h 48m
Deal found 9/16![Frontier logo]()
$337
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:25 pm -
1 stop7h 20m
Mon 10/1912:20 pm -
1 stop9h 50m
Deal found 9/16![Southwest logo]()
$345
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:59 pm -
2 stops18h 06m
Fri 10/237:13 pm -
1 stop17h 00m
Deal found 9/18![Frontier logo]()
$346
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:05 am -
2 stops8h 15m
Mon 11/27:00 am -
2 stops9h 55m
Deal found 9/16![Southwest logo]()
$342
One-way flights from Indianapolis to San FranciscoSearch for one-way flight options from Indianapolis to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 21, 2026.
Search for one-way flight options from Indianapolis to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 21, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2310:30 pm -
1 stop13h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Frontier logo]()
$143
This Super.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/812:56 pm -
1 stop14h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Frontier logo]()
$144
This Frontier deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/64:41 pm -
1 stop11h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Frontier logo]()
$145
This Frontier deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/134:08 pm -
1 stop11h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Frontier logo]()
$146
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/192:40 pm -
1 stop7h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Southwest logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/204:08 pm -
2 stops25h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Frontier logo]()
$148
This Cheapflightsfares deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/248:56 pm -
1 stop6h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Frontier logo]()
$153
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:10 pm -
2 stops8h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Southwest logo]()
$156
This Super.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/34:12 pm -
1 stop11h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Frontier logo]()
$158
This Cheapflightsfares deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/24:12 pm -
1 stop11h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Frontier logo]()
$159
This Frontier deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/54:12 pm -
1 stop11h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Frontier logo]()
$161
Find flight deals from Indianapolis to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Indianapolis (IND) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $334 (Cheapflightsfares) |
One-way from | $143 (Cheapflightsfares) |
Popular in | March |
Cheapest in | April |
Average price | $383 |
Good round-trip deal | $383 or less |
Good one-way deal | $318 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Indianapolis to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 21, 2026.
Use the filters below to find and compare flights from Indianapolis to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
IndianapolisSan Francisco
IND Indianapolis - SFO San Francisco
INDSFO
Indianapolis
Tue 10/13
3:10 pm-9:05 pm
2 stops8h 55m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$156
IndianapolisSan Francisco
IND Indianapolis - SFO San Francisco
INDSFO
Indianapolis
Tue 11/24
5:00 am-9:00 am
1 stop7h 00m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$200
IndianapolisSan Francisco
IND Indianapolis - SFO San Francisco
INDSFO
Indianapolis
Fri 11/20
5:00 am-9:00 am
1 stop7h 00m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$234
IndianapolisSan Francisco
IND Indianapolis - SFO San Francisco
INDSFO
Indianapolis
Sun 11/8
6:41 am-4:44 pm
2 stops13h 03m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$235
IndianapolisSan Francisco
IND Indianapolis - SFO San Francisco
INDSFO
Indianapolis
Sat 11/21
7:05 am-7:35 pm
2 stops15h 30m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$240
IndianapolisSan Francisco
IND Indianapolis - SFO San Francisco
INDSFO
Indianapolis
Tue 10/6
12:40 pm-9:49 pm
2 stops12h 09m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$250
IndianapolisSan Francisco
IND Indianapolis - SFO San Francisco
INDSFO
Indianapolis
Sat 9/26
7:00 am-4:37 pm
2 stops12h 37m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$270
IndianapolisSan Francisco
IND Indianapolis - SFO San Francisco
INDSFO
Indianapolis
Mon 10/5
2:13 pm-11:26 pm
2 stops12h 13m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$270
IndianapolisSan Francisco
IND Indianapolis - SFO San Francisco
INDSFO
Indianapolis
Fri 9/25
3:05 pm-8:35 pm
2 stops8h 30m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$300
Quickest round-trip
IndianapolisSan Francisco
IND Indianapolis - SFO San Francisco
INDSFO
Indianapolis
Fri 12/18
7:13 am-9:27 am
Nonstop5h 14m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$314
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Indianapolis to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Indianapolis to San Francisco in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Indianapolis-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Indianapolis-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Indianapolis-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Indianapolis-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Indianapolis-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Indianapolis to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Indianapolis with our price prediction graph.
IND-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Indianapolis to San Francisco
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How far ahead should I book a flight from Indianapolis to San Francisco?
The best time to book flights from Indianapolis to San Francisco is 65 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Indianapolis to San Francisco?
Currently, April is the cheapest month in which you can book a flight from Indianapolis to San Francisco (average of $381). Flying from Indianapolis to San Francisco in March is currently the most expensive (average of $459). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from IND to SFO?
Find hourly flight availability from Indianapolis to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 21, 2026.
When flying from Indianapolis to San Francisco, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
What’s the top layover airport for flights from Indianapolis to San Francisco?
Share of 1-stop round-trip flights from Indianapolis to San Francisco chosen by Cheapflights users in the past 12 months, using the same layover each way.
Denver (DEN) – chosen by Cheapflights users on 50% of 1-stop itineraries from Indianapolis to San Francisco on Cheapflights.
What’s the cheapest layover airport for flights from Indianapolis to San Francisco?
Average round-trip fare for 1-stop flights from Indianapolis to San Francisco, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Las Vegas (LAS) is the most affordable 1-stop option, with an average round-trip price of $252.
What’s the fastest layover option from Indianapolis to San Francisco?
Shortest average travel time for 1-stop one-way flights from Indianapolis to San Francisco, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 6h 25m.
Which airport typically offers the quickest layover for flights from Indianapolis to San Francisco?
Average layover duration for 1-stop one-way flights from Indianapolis to San Francisco, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Los Angeles (LAX) offer the fastest connection on this route, with an average layover time of 1h 07m.
The best insider tips for Indianapolis to San Francisco flights
AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your Indianapolis to San Francisco trip
Our travel experts
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated September 21, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Indianapolis to San Francisco by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Comfort
8.0
Crew
8.6
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Comfort
8.0
Crew
8.6
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Comfort
8.0
Crew
8.6
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Comfort
8.0
Crew
8.6
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Comfort
8.0
Crew
8.6
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Comfort
8.0
Crew
8.6
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Indianapolis to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Emeryville
Burlingame
Rancho Cordova
San Bruno
Roseville
Hayward
Cupertino
Newark
Fairfield
San Ramon
Redwood City
Manteca
Vallejo
San Carlos
Turlock
Davis
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Indianapolis and San Francisco flights
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Top 6 airlines flying from Indianapolis to San Francisco
Discover the top 6 airlines that operate flights from Indianapolis to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$150 | Average$281 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$228 | Average$386 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$269 | Average$424 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$278 | Average$441 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$284 | Average$415 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$288 | Average$386 | FlexibilityNo cancel fee | On-timeN/A |