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$80+ Cheap flights from Indiana to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/8. Fares are subject to change and may not be available on all flights or dates of travel.
IND — SFO
Apr 25 — May 21
Sat 4/25
Sat 5/2
1 adult, Economy
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Cheap flight deals from Indiana to San Francisco

Cheapest flights from Indiana to San Francisco
Explore the most affordable flight options available from Indiana to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2026.

This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/219:27 am
MDW
-
SFO
1 stop7h 28m
Delta
Wed 4/2210:55 pm
SFO
-
MDW
1 stop7h 52m
Delta
Deal found 3/26$237
This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/148:20 am
ORD
-
SFO
1 stop8h 17m
Multiple Airlines
Tue 4/146:29 pm
SFO
-
ORD
1 stop9h 21m
Multiple Airlines
Deal found 3/23$237
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2212:50 pm
MDW
-
SFO
2 stops10h 35m
Southwest
Wed 4/292:50 pm
SFO
-
MDW
1 stop6h 30m
Southwest
Deal found 3/23$238
This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1411:07 am
ORD
-
SFO
2 stops28h 45m
Frontier
Wed 4/156:29 pm
SFO
-
ORD
1 stop9h 21m
Frontier
Deal found 3/23$238
This Southwest deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2112:50 pm
MDW
-
SFO
2 stops10h 35m
Southwest
Tue 4/2810:40 pm
SFO
-
MDW
1 stop7h 45m
Southwest
Deal found 3/22$239
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/214:50 pm
ORD
-
SFO
1 stop8h 25m
Southwest
Tue 4/2810:05 am
SFO
-
ORD
2 stops10h 50m
Southwest
Deal found 3/23$239
This Expedia deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/148:56 pm
ORD
-
SFO
1 stop26h 08m
Frontier
Mon 5/1811:59 pm
SFO
-
ORD
1 stop9h 41m
Frontier
Deal found 3/24$240
This CheapOair deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/93:07 pm
MDW
-
SFO
1 stop9h 57m
Frontier
Sat 8/2211:52 pm
SFO
-
MDW
1 stop12h 15m
Frontier
Deal found 3/26$241
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/89:42 pm
ORD
-
SFO
2 stops25h 37m
Frontier
Sat 8/88:30 pm
SFO
-
ORD
1 stop7h 49m
Frontier
Deal found 3/26$241
This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:05 pm
ORD
-
SFO
1 stop30h 59m
Multiple Airlines
Wed 8/198:30 pm
SFO
-
ORD
1 stop7h 49m
Multiple Airlines
Deal found 3/23$242
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/512:50 pm
MDW
-
SFO
2 stops10h 35m
Southwest
Tue 5/126:20 am
SFO
-
MDW
2 stops8h 15m
Southwest
Deal found 3/25$243
This Orbitz deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/154:10 pm
ORD
-
SFO
1 stop8h 42m
Multiple Airlines
Sat 4/1810:38 pm
SFO
-
ORD
1 stop10h 59m
Multiple Airlines
Deal found 3/24$243

Find flight deals from Indiana to San Francisco

Keep the following information in mind while searching for Indiana to San Francisco flight deals. Data was last updated March 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$237
(Kiwi.com)

One-way from

$80
(Travelocity)

Popular in

March

Cheapest in

September

Average price

$438

Good round-trip deal

$325 or less

Good one-way deal

$254 or less
Provider with most accurate pricing for Indianapolis-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Indianapolis-San Francisco flights.
Search Deals
From Indiana to San Francisco
Search Deals
One-way flight from Indiana to San Francisco
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($14 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals
Price to beat on a round-trip flight from Indiana to San Francisco.
Search Deals
Price to beat on a one-way flight from Indiana to San Francisco.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indiana to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from Indiana to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoSan Francisco

ORD - SFO

ORDSFO

Chicago O'Hare Intl

Tue 4/21

4:50 pm-11:15 pm

1 stop8h 25m

San Francisco

Tue 4/28

7:20 am-6:50 pm

2 stops9h 30m

$239

ChicagoSan Francisco

ORD - SFO

ORDSFO

Chicago O'Hare Intl

Fri 4/17

4:40 pm-7:37 pm

Nonstop4h 57m

San Francisco

Mon 4/20

6:29 pm-12:59 am

Nonstop4h 30m

$289
Quickest round-trip

ChicagoSan Francisco

MDW - SFO

MDWSFO

Chicago Midway

Fri 5/15

9:45 pm-12:20 am

Nonstop4h 35m

San Francisco

Mon 5/18

11:25 pm-5:40 am

Nonstop4h 15m

$290

ChicagoSan Francisco

ORD - SFO

ORDSFO

Chicago O'Hare Intl

Thu 5/14

7:20 pm-12:10 am

1 stop6h 50m

San Francisco

Wed 5/20

10:30 am-11:55 pm

1 stop11h 25m

$300

ChicagoSan Francisco

ORD - SFO

ORDSFO

Chicago O'Hare Intl

Fri 5/15

4:15 pm-11:45 pm

2 stops9h 30m

San Francisco

Wed 5/20

7:40 am-10:55 pm

2 stops13h 15m

$303

ChicagoSan Francisco

ORD - SFO

ORDSFO

Chicago O'Hare Intl

Thu 5/7

4:15 pm-12:10 am

2 stops9h 55m

San Francisco

Tue 5/12

7:20 am-6:50 pm

2 stops9h 30m

$305

ChicagoSan Francisco

MDW - SFO

MDWSFO

Chicago Midway

Sat 4/18

6:10 pm-8:45 pm

Nonstop4h 35m

San Francisco

Sat 4/25

11:25 pm-5:40 am

Nonstop4h 15m

$313

ChicagoSan Francisco

MDW - SFO

MDWSFO

Chicago Midway

Wed 5/6

9:00 pm-11:35 pm

Nonstop4h 35m

San Francisco

Wed 5/13

11:25 pm-5:40 am

Nonstop4h 15m

$313

ChicagoSan Francisco

MDW - SFO

MDWSFO

Chicago Midway

Wed 4/15

6:00 am-12:33 pm

1 stop8h 33m

San Francisco

Sun 4/19

10:55 pm-8:47 am

1 stop7h 52m

$332

ChicagoSan Francisco

ORD - SFO

ORDSFO

Chicago O'Hare Intl

Sat 5/30

7:40 am-10:29 am

Nonstop4h 49m

San Francisco

Mon 6/1

12:50 am-7:16 am

Nonstop4h 26m

$335

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/22

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Indiana to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Indiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indiana to San Francisco

What is the cheapest month to book a flight from Indiana to San Francisco?

Currently, May is the cheapest month in which you can book a flight from Indiana to San Francisco (average of $157). Flying from Indiana to San Francisco in February is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IN to SFO?

Find hourly flight availability from Indiana to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 26, 2026.

One of the essential ways to save on airfare from Indiana to San Francisco is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the morning could potentially save you up to 52% on airfare.

How much does it cost to fly round-trip from Indiana to San Francisco?

Related info for your journey

Find useful and relevant information for your journey from Indiana to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from Indiana?

    San Francisco (SFO), located 11.0 mi from the city center, is the airport you fly into when you book flights from Indiana to San Francisco.

  • How popular is this Indiana to San Francisco flight route?

    Flights from Indiana to San Francisco have been viewed 41 times in the past calendar month.

  • How long is the flight from Indiana to San Francisco?

    A quick flight from Indiana to San Francisco can take about 4h 57m. Southwest provides one of the quickest options available for as low as $289. There are 1841 mi between Indiana and San Francisco. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Indiana to San Francisco one-way?

    One-way options have recently been found by users for as low as $66 on ZIPAIR. Other airlines that offer cheap prices include Hawaiian Airlines from $248 and AIR PREMIA from $281 one-way.

  • What are the most popular routes from Indiana to San Francisco?

    The most popular route from Indiana to San Francisco is Chicago O'Hare Intl - San Francisco. You may also consider Chicago Midway - San Francisco or Indianapolis - San Francisco.

  • What are the most reliable airlines from Indiana to San Francisco?

    Before booking your flight to San Francisco from Indiana, check out the most reliable airlines to get you to your destination on time: United Airlines (87%), Air New Zealand (87%), Virgin Australia( 87%).

  • What are the cheapest flights from Indiana to San Francisco?

    On average you can expect to pay $511 for a flight from Indiana to San Francisco. The cheapest flight overall is $178 while the most popular route, (Chicago O'Hare Intl - San Francisco) is currently priced at $172.

  • Can I find deals for flights from Indiana to San Francisco that include hotel bookings?

    Yes. In addition to deals on Indiana to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indiana to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indiana to San Francisco.

  • Can I find deals for business class flights from Indiana to San Francisco?

    Yes. Cheapflights offers flight deals from Indiana to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indiana to San Francisco?

    Currently, May is the cheapest month in which you can book a flight from Indiana to San Francisco (average of $157). Flying from Indiana to San Francisco in February is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Cruz
Santa Clara
Livermore
Roseville
Rancho Cordova
San Bruno
Watsonville
San Ramon
Sunnyvale
Vacaville
San Carlos
Turlock
Redwood City
San Lorenzo
Davis
Manteca
Union City
Elk Grove
Rohnert Park

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Alternative routes for Indiana to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Indiana to San Francisco

Discover the top 6 airlines that operate flights from Indiana to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$150Average$278FlexibilityNo cancel feeOn-time62%
DeltaCheapest$165Average$370FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$240Average$419FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$269Average$422FlexibilityNo cancel feeOn-time69%
JetBlueCheapest$278Average$441FlexibilityNo cancel feeOn-time62%
SouthwestCheapest$284Average$402FlexibilityNo cancel feeOn-time63%

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