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$117+ Cheap flights from Florida Keys to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/17. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Nov 20 — Nov 271
Thu 11/20
Thu 11/27
1 adult, Economy
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Find flight deals from Florida Keys to San Francisco

Cheapest flights from Florida Keys to San Francisco
Explore the most affordable flight options available from Florida Keys to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 21, 2025.

This Booking.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:15 amMIA - SFO
1 stop28h 53mFrontier
Sat 12/136:30 amSFO - MIA
1 stop19h 49mFrontier
Deal found 10/20$233
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/88:45 amMIA - SFO
Nonstop6h 34mUnited Airlines
Sat 11/812:43 amSFO - MIA
1 stop7h 10mUnited Airlines
Deal found 10/20$237
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/410:15 pmMIA - SFO
2 stops26h 07mFrontier
Sat 11/810:23 pmSFO - MIA
1 stop8h 48mFrontier
Deal found 10/20$238
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/37:00 amMIA - SFO
1 stop8h 09mUnited Airlines
Tue 12/91:15 pmSFO - MIA
Nonstop5h 30mUnited Airlines
Deal found 10/20$241
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/317:07 pmMIA - SFO
1 stop29h 04mFrontier
Thu 11/610:11 pmSFO - MIA
2 stops37h 19mFrontier
Deal found 10/19$242
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:42 amMIA - SFO
Nonstop6h 38mUnited Airlines
Wed 12/3112:30 amSFO - MIA
1 stop9h 38mUnited Airlines
Deal found 10/19$243
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/36:00 pmMIA - SFO
Nonstop6h 32mUnited Airlines
Thu 11/611:05 pmSFO - MIA
Nonstop5h 30mUnited Airlines
Deal found 10/20$244
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:00 pmMIA - SFO
Nonstop6h 32mUnited Airlines
Sun 11/165:00 amSFO - MIA
1 stop8h 04mUnited Airlines
Deal found 10/20$245
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/78:45 amMIA - SFO
Nonstop6h 34mUnited Airlines
Wed 11/1211:59 pmSFO - MIA
1 stop7h 54mUnited Airlines
Deal found 10/20$247
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/67:44 amMIA - SFO
Nonstop6h 22mAmerican Airlines
Tue 12/91:17 pmSFO - MIA
Nonstop5h 33mAmerican Airlines
Deal found 10/19$248
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/157:44 amMIA - SFO
Nonstop6h 23mAmerican Airlines
Tue 11/181:15 pmSFO - MIA
Nonstop5h 30mAmerican Airlines
Deal found 10/19$249
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/51:33 pmEYW - SFO
1 stop10h 27mAmerican Airlines
Sun 11/911:59 pmSFO - EYW
1 stop8h 15mAmerican Airlines
Deal found 10/21$369

Cheap flight deals from Florida Keys to San Francisco

Keep the following information in mind while searching for Florida Keys to San Francisco flight deals. Data was last updated October 21, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$233
(United Airlines)

One-way from

$117
(Kiwi.com)
Provider with most accurate pricing for Key West-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-San Francisco flights.
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From Florida Keys to San Francisco
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One-way flight from Florida Keys to San Francisco
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 21, 2025.
Use the filters below to find and compare flights from Florida Keys to San Francisco that are best for you.

Fly from

Florida Keys

Fly to

San Francisco

Route

Depart

Return

Price

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Fri 11/14

12:51 pm-7:20 pm

1 stop9h 29m

San Francisco

Mon 11/17

11:05 pm-7:35 am

Nonstop5h 30m

$237

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Sat 11/15

7:00 am-12:23 pm

1 stop8h 23m

San Francisco

Mon 11/17

12:30 am-1:32 pm

1 stop10h 02m

$257

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Mon 11/10

7:40 am-2:35 pm

1 stop9h 55m

San Francisco

Thu 11/13

6:00 am-5:33 pm

1 stop8h 33m

$257

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Thu 12/4

3:50 pm-8:59 pm

1 stop8h 09m

San Francisco

Sun 12/7

12:30 am-1:32 pm

1 stop10h 02m

$257

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Wed 12/3

7:39 am-2:36 pm

1 stop9h 57m

San Francisco

Mon 12/8

12:30 am-1:32 pm

1 stop10h 02m

$257

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Sat 12/6

8:10 am-2:23 pm

1 stop9h 13m

San Francisco

Sat 12/13

10:30 pm-9:27 am

1 stop7h 57m

$257

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Fri 12/12

8:30 am-12:03 pm

Nonstop6h 33m

San Francisco

Mon 12/15

7:20 am-5:53 pm

1 stop7h 33m

$258

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Fri 2/20

6:10 am-2:20 pm

1 stop11h 10m

San Francisco

Sat 2/28

8:00 am-10:30 pm

1 stop11h 30m

$265

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Thu 1/8

6:15 pm-9:50 pm

Nonstop6h 35m

San Francisco

Wed 1/14

12:43 am-1:30 pm

1 stop9h 47m

$267

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Fri 11/7

8:30 am-2:13 pm

1 stop8h 43m

San Francisco

Sun 11/9

5:45 am-6:09 pm

1 stop9h 24m

$267

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/20

Showing 1-10 of 31 results
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Best time to book a flight from Florida Keys to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to San Francisco
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated October 21, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Florida Keys to San Francisco by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,978 reviews

Boarding

8.2

Comfort

7.9

Overall

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
7.9
Good
7,978 reviews
Delta
7.9
Good
7,978 reviews

Boarding

8.2

Comfort

7.9

Overall

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,991 reviews
Delta
7.9
Good
7,978 reviews

Boarding

8.2

Comfort

7.9

Overall

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
11,023 reviews
Delta
7.9
Good
7,978 reviews

Boarding

8.2

Comfort

7.9

Overall

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
JetBlue
7.2
Good
2,909 reviews
Delta
7.9
Good
7,978 reviews

Boarding

8.2

Comfort

7.9

Overall

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Frontier
5.8
Fair
3,130 reviews
Delta
7.9
Good
7,978 reviews

Boarding

8.2

Comfort

7.9

Overall

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from Florida Keys?

    Most people fly into San Francisco (SFO) if they book a flight to San Francisco from Florida Keys. San Francisco is conveniently located just 11.8 mi from San Francisco’s city center.

  • How long is the flight from Florida Keys to San Francisco?

    Airlines like United Airlines, Delta, and American Airlines fly from Florida Keys to San Francisco in about 8h 23m. The time it takes to get you to your destination can typically vary by up to 2h 04m. The distance from Florida Keys to San Francisco is about 2579 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Florida Keys to San Francisco that include hotel bookings?

    Yes. In addition to deals on Florida Keys to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to San Francisco.

  • Can I find deals for business class flights from Florida Keys to San Francisco?

    Yes. Cheapflights offers flight deals from Florida Keys to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
Santa Cruz
Livermore
South San Francisco
Turlock
Antioch
Watsonville
Santa Clara
Manteca
Sunnyvale
Vacaville
Vallejo
Hollister
Foster City
Union City
Fairfield
Burlingame
Redwood City
Lodi
San Mateo

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Florida Keys to San Francisco

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Top airline flying from Florida Keys to San Francisco

Discover the top airline that operate flights from Florida Keys to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 21, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$313Average$453FlexibilityNo cancel feeOn-time71%

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