HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Francisco

$129+ Cheap flights from Florida Keys to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/10. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Jan 8 — Jan 151
Thu 1/8
Thu 1/15
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Florida Keys to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Florida Keys to San Francisco

Cheapest flights from Florida Keys to San Francisco
Explore the most affordable flight options available from Florida Keys to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 9, 2025.

This Mytrip deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/207:05 amMIA - SFO
1 stop27h 43mFrontier
Mon 1/56:00 amSFO - MIA
1 stop20h 35mFrontier
Deal found 12/9$237
This Mytrip deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/176:00 amMIA - SFO
1 stop29h 23mFrontier
Thu 1/226:15 amSFO - MIA
1 stop7h 22mFrontier
Deal found 12/8$239
This United Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:20 amMIA - SFO
1 stop8h 54mUnited Airlines
Wed 1/711:18 pmSFO - MIA
Nonstop5h 33mUnited Airlines
Deal found 12/8$255
This Booking.com deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/96:00 amMIA - SFO
1 stop21h 24mFrontier
Thu 1/226:15 amSFO - MIA
1 stop7h 22mFrontier
Deal found 12/8$261
This Mytrip deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/176:00 amMIA - SFO
1 stop29h 23mFrontier
Wed 1/77:00 amSFO - MIA
1 stop25h 57mFrontier
Deal found 12/8$263
This Super.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/176:00 amMIA - SFO
1 stop29h 23mFrontier
Mon 1/56:00 amSFO - MIA
1 stop20h 35mFrontier
Deal found 12/9$265
This United Airlines deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/251:33 pmMIA - SFO
1 stop8h 26mUnited Airlines
Mon 1/511:03 pmSFO - MIA
Nonstop5h 33mUnited Airlines
Deal found 12/6$269
This Super.com deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:30 amMIA - SFO
1 stop10h 43mFrontier
Fri 12/2611:20 pmSFO - MIA
1 stop8h 38mFrontier
Deal found 12/7$275
This Frontier deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/187:05 amMIA - SFO
1 stop8h 29mFrontier
Fri 1/24:06 pmSFO - MIA
1 stop10h 29mFrontier
Deal found 12/8$278
This Booking.com deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/207:05 amMIA - SFO
1 stop27h 43mFrontier
Mon 12/296:00 amSFO - MIA
1 stop20h 35mFrontier
Deal found 12/8$280
This Trip.com deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2311:30 amEYW - SFO
2 stops15h 54mMultiple Airlines
Sat 12/278:44 pmSFO - EYW
1 stop12h 33mMultiple Airlines
Deal found 12/8$777
This United Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/234:10 pmEYW - SFO
1 stop12h 04mUnited Airlines
Sat 12/279:10 pmSFO - EYW
1 stop11h 31mUnited Airlines
Deal found 12/8$928

Find flight deals from Florida Keys to San Francisco

Keep the following information in mind while searching for Florida Keys to San Francisco flight deals. Data was last updated December 9, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$226
(Kiwi.com)

One-way from

$129
(Kiwi.com)
Provider with most accurate pricing for Key West-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-San Francisco flights.
Search Deals
From Florida Keys to San Francisco
Search Deals
One-way flight from Florida Keys to San Francisco
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 9, 2025.
Use the filters below to find and compare flights from Florida Keys to San Francisco that are best for you.

Fly from

Florida Keys

Fly to

San Francisco

Route

Depart

Return

Price

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Sat 1/17

6:05 am-9:43 am

Nonstop6h 38m

San Francisco

Sat 1/24

8:30 am-5:06 pm

Nonstop5h 36m

$231

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Sun 2/8

6:20 am-12:20 pm

1 stop9h 00m

San Francisco

Tue 2/10

8:30 am-5:06 pm

Nonstop5h 36m

$255

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Tue 1/13

11:05 am-4:50 pm

1 stop8h 45m

San Francisco

Mon 2/2

8:30 am-5:06 pm

Nonstop5h 36m

$255

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Sat 1/17

7:00 am-7:10 pm

1 stop15h 10m

San Francisco

Sat 1/24

10:25 am-9:30 pm

1 stop8h 05m

$256

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Tue 2/3

7:39 am-4:05 pm

1 stop11h 26m

San Francisco

Sat 2/7

9:30 pm-9:24 am

1 stop8h 54m

$257

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Fri 1/16

6:05 am-9:43 am

Nonstop6h 38m

San Francisco

Mon 1/19

11:18 pm-7:51 am

Nonstop5h 33m

$259

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Fri 1/23

6:05 am-9:43 am

Nonstop6h 38m

San Francisco

Mon 1/26

11:18 pm-7:51 am

Nonstop5h 33m

$259

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Sat 3/7

7:23 am-10:59 am

Nonstop6h 36m

San Francisco

Tue 3/10

8:32 am-4:56 pm

Nonstop5h 24m

$259

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Fri 2/27

7:50 am-3:03 pm

1 stop10h 13m

San Francisco

Tue 3/3

10:54 pm-10:21 am

1 stop8h 27m

$268

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Thu 1/8

4:19 pm-11:00 pm

1 stop9h 41m

San Francisco

Mon 1/12

11:18 pm-7:51 am

Nonstop5h 33m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/8

Showing 1-10 of 28 results
1
2
3

Best time to book a flight from Florida Keys to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to San Francisco
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated December 9, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Florida Keys to San Francisco by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
9,092 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
11,048 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
JetBlue
7.2
Good
2,899 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Frontier
5.8
Fair
3,085 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from Florida Keys?

    Most people fly into San Francisco (SFO) if they book a flight to San Francisco from Florida Keys. San Francisco is conveniently located just 11.8 mi from San Francisco’s city center.

  • How long is the flight from Florida Keys to San Francisco?

    Airlines like United Airlines, Southwest, and American Airlines fly from Florida Keys to San Francisco in about 6h 38m. The time it takes to get you to your destination can typically vary by up to 8h 32m. The distance from Florida Keys to San Francisco is about 2579 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Florida Keys to San Francisco one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $82. Users have also found prices from $89 and $111 on JetBlue and American Airlines, respectively.

  • Can I find deals for flights from Florida Keys to San Francisco that include hotel bookings?

    Yes. In addition to deals on Florida Keys to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to San Francisco.

  • Can I find deals for business class flights from Florida Keys to San Francisco?

    Yes. Cheapflights offers flight deals from Florida Keys to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
South San Francisco
Santa Cruz
Livermore
Turlock
Manteca
Watsonville
Sunnyvale
Santa Clara
San Bruno
Redwood City
Daly City
Vallejo
Hollister
Foster City
Union City
Davis
San Ramon
Burlingame
Milpitas

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Florida Keys to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.
Orlando to Las Vegas flights
Fort Lauderdale to Las Vegas flights
Miami to Las Vegas flights
Orlando to Los Angeles flights
Tampa to Las Vegas flights
Miami to Los Angeles flights
Fort Lauderdale to Los Angeles flights
Orlando to San Francisco flights
Tampa to Los Angeles flights
Miami to San Francisco flights
Tampa to San Francisco flights
West Palm Beach to Los Angeles flights
Miami to Ontario flights
Fort Lauderdale to San Francisco flights
Jacksonville to Las Vegas flights
Orlando to San Diego flights
Fort Lauderdale to Santa Ana flights
Fort Myers to Las Vegas flights
West Palm Beach to Las Vegas flights
Tampa to San Diego flights
Miami to San Diego flights
Fort Lauderdale to Burbank flights
Orlando to Ontario flights
Fort Lauderdale to Ontario flights
Jacksonville to Los Angeles flights
Pensacola to Las Vegas flights
Fort Lauderdale to San Diego flights
Sarasota to Las Vegas flights
Jacksonville to San Diego flights
Orlando to Sacramento flights
Orlando to Santa Ana flights
Tampa to Santa Ana flights
Tampa to Ontario flights
Miami to Santa Ana flights
Miami to San Jose flights
Tampa to Reno flights
Orlando Sanford Intl to Las Vegas flights
Fort Myers to Los Angeles flights
Pensacola to Los Angeles flights
Jacksonville to Ontario flights
West Palm Beach to Ontario flights
Valparaiso to Los Angeles flights
Jacksonville to San Francisco flights
Tampa to Burbank flights
Tampa to San Jose flights
Orlando to San Jose flights
Panama City to Las Vegas flights
Miami to Burbank flights
West Palm Beach to San Francisco flights
Tampa to Palm Springs flights

Top airline flying from Florida Keys to San Francisco

Discover the top airline that operate flights from Florida Keys to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 9, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$313Average$453FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.