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$116+ Cheap flights from Florida Keys to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/15. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Feb 25 — Mar 41
Wed 2/25
Wed 3/4
1 adult, Economy
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Cheap flight deals from Florida Keys to San Francisco

Cheapest flights from Florida Keys to San Francisco
Explore the most affordable flight options available from Florida Keys to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:45 am
MIA
-
SFO
1 stop21h 43m
Frontier
Thu 3/510:40 pm
SFO
-
MIA
1 stop23h 07m
Frontier
Deal found 1/26$204
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/54:10 pm
MIA
-
SFO
1 stop11h 06m
United Airlines
Sun 3/811:00 pm
SFO
-
MIA
Nonstop5h 27m
United Airlines
Deal found 1/26$205
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/138:17 pm
MIA
-
SFO
Nonstop6h 42m
American Airlines
Mon 2/1610:55 pm
SFO
-
MIA
Nonstop5h 28m
American Airlines
Deal found 1/26$209
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:45 am
MIA
-
SFO
1 stop19h 16m
Frontier
Thu 2/2610:46 pm
SFO
-
MIA
1 stop8h 42m
Frontier
Deal found 1/25$211
This CheapOair deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:00 am
MIA
-
SFO
1 stop16h 10m
Frontier
Tue 4/145:47 pm
SFO
-
MIA
1 stop10h 45m
Frontier
Deal found 1/26$212
This Kiwi.com deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/75:50 am
MIA
-
SFO
1 stop14h 58m
Frontier
Wed 3/116:00 am
SFO
-
MIA
2 stops15h 06m
Frontier
Deal found 1/24$214
This Frontier deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:42 am
MIA
-
SFO
1 stop11h 10m
Frontier
Wed 5/63:31 pm
SFO
-
MIA
1 stop13h 01m
Frontier
Deal found 1/26$215
This Super.com deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:25 am
MIA
-
SFO
1 stop21h 03m
Frontier
Sun 2/2210:46 pm
SFO
-
MIA
1 stop8h 42m
Frontier
Deal found 1/24$216
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/15:05 am
MIA
-
SFO
1 stop19h 34m
Frontier
Tue 3/310:55 pm
SFO
-
MIA
1 stop8h 33m
Frontier
Deal found 1/25$217
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/128:35 am
MIA
-
SFO
Nonstop6h 36m
United Airlines
Tue 2/175:00 am
SFO
-
MIA
1 stop7h 39m
United Airlines
Deal found 1/26$219
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/143:09 pm
MIA
-
SFO
2 stops22h 06m
Frontier
Tue 2/1710:55 pm
SFO
-
MIA
1 stop8h 33m
Frontier
Deal found 1/26$220
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/243:20 pm
EYW
-
SFO
1 stop10h 00m
American Airlines
Tue 3/316:00 am
SFO
-
EYW
1 stop9h 19m
American Airlines
Deal found 1/25$304

Find flight deals from Florida Keys to San Francisco

Keep the following information in mind while searching for Florida Keys to San Francisco flight deals. Data was last updated January 26, 2026.

Most accurate provider

Expedia
2 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$211
(Kiwi.com)

One-way from

$116
(United Airlines)
Provider with most accurate pricing for Key West-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-San Francisco flights.
Search Deals
From Florida Keys to San Francisco
Search Deals
One-way flight from Florida Keys to San Francisco
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from Florida Keys to San Francisco that are best for you.

Fly from

Florida Keys

Fly to

San Francisco

Route

Depart

Return

Price

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Thu 2/12

8:35 am-12:11 pm

Nonstop6h 36m

San Francisco

Tue 2/17

5:00 am-3:39 pm

1 stop7h 39m

$219

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Tue 3/24

11:40 am-9:05 pm

1 stop12h 25m

San Francisco

Tue 3/31

10:55 pm-2:55 pm

1 stop13h 00m

$230

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Thu 3/26

8:05 am-3:03 pm

1 stop9h 58m

San Francisco

Mon 4/6

11:35 pm-10:44 am

1 stop8h 09m

$257

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Fri 4/17

8:04 am-2:55 pm

1 stop9h 51m

San Francisco

Sun 4/19

9:35 pm-9:20 am

1 stop8h 45m

$257

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Thu 4/2

11:35 am-8:05 pm

1 stop11h 30m

San Francisco

Sun 4/5

11:25 pm-1:50 pm

2 stops11h 25m

$269

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Fri 2/6

6:15 pm-9:50 pm

Nonstop6h 35m

San Francisco

Sun 2/8

11:18 pm-7:51 am

Nonstop5h 33m

$273

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Fri 2/27

6:02 pm-9:50 pm

Nonstop6h 48m

San Francisco

Mon 3/2

11:00 pm-7:27 am

Nonstop5h 27m

$273

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Fri 2/20

8:35 am-12:11 pm

Nonstop6h 36m

San Francisco

Mon 2/23

11:00 pm-7:27 am

Nonstop5h 27m

$273

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Thu 3/19

7:23 am-10:59 am

Nonstop6h 36m

San Francisco

Sun 3/22

11:59 pm-1:24 pm

1 stop10h 25m

$275

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Tue 2/3

6:15 pm-9:50 pm

Nonstop6h 35m

San Francisco

Mon 2/9

11:20 pm-11:16 am

1 stop8h 56m

$293

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/24

Showing 1-10 of 32 results
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Best time to book a flight from Florida Keys to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to San Francisco
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated January 26, 2026.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Florida Keys to San Francisco by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,113 reviews

Food

7.2

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
7.9
Good
8,113 reviews
Delta
7.9
Good
8,113 reviews

Food

7.2

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
9,198 reviews
Delta
7.9
Good
8,113 reviews

Food

7.2

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
11,189 reviews
Delta
7.9
Good
8,113 reviews

Food

7.2

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
JetBlue
7.2
Good
2,893 reviews
Delta
7.9
Good
8,113 reviews

Food

7.2

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Frontier
5.7
Fair
3,057 reviews
Delta
7.9
Good
8,113 reviews

Food

7.2

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from Florida Keys?

    Most people fly into San Francisco (SFO) if they book a flight to San Francisco from Florida Keys. San Francisco is conveniently located just 11.8 mi from San Francisco’s city center.

  • How long is the flight from Florida Keys to San Francisco?

    Airlines like United Airlines, Southwest, and Delta fly from Florida Keys to San Francisco in about 6h 36m. The time it takes to get you to your destination can typically vary by up to 5h 49m. The distance from Florida Keys to San Francisco is about 2579 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Florida Keys to San Francisco one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $82. Users have also found prices from $99 and $113 on JetBlue and American Airlines, respectively.

  • Can I find deals for flights from Florida Keys to San Francisco that include hotel bookings?

    Yes. In addition to deals on Florida Keys to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to San Francisco.

  • Can I find deals for business class flights from Florida Keys to San Francisco?

    Yes. Cheapflights offers flight deals from Florida Keys to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Cruz
Roseville
Santa Clara
Livermore
Watsonville
San Bruno
Daly City
Sunnyvale
Turlock
Vacaville
San Carlos
San Ramon
Manteca
Vallejo
San Lorenzo
Davis
Hollister
Redwood City
Union City

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Florida Keys to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Florida Keys to San Francisco

Discover the top airline that operate flights from Florida Keys to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$313Average$453FlexibilityNo cancel feeOn-time71%

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