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$121+ Cheap flights from Florida Keys to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/8. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Aug 23 — Aug 301
Sat 8/23
Sat 8/30
1 adult, Economy
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Cheap flight deals from Florida Keys to San Francisco

Keep the following information in mind while searching for Florida Keys to San Francisco flight deals. Data was last updated August 18, 2025.

Round-trip from

$227
(American Airlines)

One-way from

$121
(Frontier)
From Florida Keys to San Francisco
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One-way flight from Florida Keys to San Francisco
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Find flight deals from Florida Keys to San Francisco

Cheapest flights from Florida Keys to San Francisco
Explore the most affordable flight options available from Florida Keys to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.

This CheapOair deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:57 pmMIA - SFO
1 stop29h 26mFrontier
Sun 10/196:34 amSFO - MIA
1 stop20h 45mFrontier
Deal found 8/18$226
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/97:43 pmMIA - SFO
Nonstop6h 11mAmerican Airlines
Wed 9/2411:10 amSFO - MIA
Nonstop5h 51mAmerican Airlines
Deal found 8/16$227
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/17:43 pmMIA - SFO
Nonstop6h 11mAmerican Airlines
Wed 10/812:27 pmSFO - MIA
Nonstop5h 28mAmerican Airlines
Deal found 8/17$228
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/209:07 pmMIA - SFO
2 stops27h 14mMultiple Airlines
Sun 9/286:29 amSFO - MIA
1 stop15h 15mMultiple Airlines
Deal found 8/18$229
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/46:45 amMIA - SFO
1 stop18h 45mFrontier
Tue 10/76:34 amSFO - MIA
2 stops12h 15mFrontier
Deal found 8/16$230
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/136:35 pmMIA - SFO
Nonstop6h 14mUnited Airlines
Sat 9/208:55 amSFO - MIA
Nonstop5h 38mUnited Airlines
Deal found 8/16$231
This CheapOair deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:25 pmMIA - SFO
1 stop29h 56mFrontier
Sun 9/1411:57 pmSFO - MIA
1 stop16h 00mFrontier
Deal found 8/18$232
This Frontier deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/59:28 amMIA - SFO
2 stops17h 48mFrontier
Sun 9/710:37 pmSFO - MIA
2 stops21h 23mFrontier
Deal found 8/17$233
This Frontier deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/199:28 amMIA - SFO
2 stops16h 34mFrontier
Thu 9/2510:37 pmSFO - MIA
2 stops16h 57mFrontier
Deal found 8/17$234
This Southwest deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/3011:40 amMIA - SFO
1 stop9h 40mSouthwest
Sat 9/69:55 amSFO - MIA
1 stop8h 45mSouthwest
Deal found 8/16$235
This Frontier deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/88:00 amMIA - SFO
2 stops16h 21mFrontier
Thu 9/118:46 amSFO - MIA
2 stops12h 58mFrontier
Deal found 8/16$236
This Frontier deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1312:18 pmMIA - SFO
2 stops13h 12mFrontier
Wed 9/178:00 amSFO - MIA
2 stops13h 44mFrontier
Deal found 8/16$237

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Florida Keys to San Francisco that are best for you.

Fly from

Florida Keys

Fly to

San Francisco

Route

Depart

Return

Price

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Wed 10/1

7:43 pm-10:54 pm

Nonstop6h 11m

San Francisco

Tue 10/7

11:59 pm-8:23 am

Nonstop5h 24m

$227

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Wed 9/24

6:59 pm-11:15 pm

2 stops31h 16m

San Francisco

Sun 9/28

6:29 am-12:44 am

1 stop15h 15m

$227

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Tue 9/9

7:43 pm-10:54 pm

Nonstop6h 11m

San Francisco

Wed 9/24

11:10 am-8:01 pm

Nonstop5h 51m

$227

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Sat 9/20

9:07 pm-9:21 pm

2 stops27h 14m

San Francisco

Sun 9/28

6:29 am-12:44 am

1 stop15h 15m

$229

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Fri 10/31

7:40 pm-10:59 pm

Nonstop6h 19m

San Francisco

Sun 11/2

11:59 pm-8:18 am

Nonstop5h 19m

$229

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Fri 10/3

8:00 am-6:19 pm

2 stops13h 19m

San Francisco

Sun 10/5

10:37 pm-11:00 pm

2 stops21h 23m

$231

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Sat 9/13

6:35 pm-9:49 pm

Nonstop6h 14m

San Francisco

Sat 9/20

8:55 am-5:33 pm

Nonstop5h 38m

$231

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Sat 9/13

6:35 pm-9:49 pm

Nonstop6h 14m

San Francisco

Wed 9/17

8:55 am-5:33 pm

Nonstop5h 38m

$231

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Sat 10/4

7:43 pm-10:54 pm

Nonstop6h 11m

San Francisco

Tue 10/7

11:59 pm-8:23 am

Nonstop5h 24m

$231

MiamiSan Francisco

MIA - SFO

MIASFO

Miami

Wed 9/10

6:25 pm-9:21 pm

1 stop29h 56m

San Francisco

Sun 9/14

11:57 pm-6:57 pm

1 stop16h 00m

$232

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/17

Showing 1-10 of 31 results
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Best time to book a flight from Florida Keys to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to San Francisco
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated August 18, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Florida Keys to San Francisco by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,925 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
JetBlue
7.2
Good
2,915 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Frontier
5.8
Fair
3,212 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from Florida Keys?

    Most people fly into San Francisco (SFO) if they book a flight to San Francisco from Florida Keys. San Francisco is conveniently located just 11.8 mi from San Francisco’s city center.

  • How long is the flight from Florida Keys to San Francisco?

    Airlines like American Airlines and Delta fly from Florida Keys to San Francisco in about 6h 11m. The time it takes to get you to your destination can typically vary by up to 1h 41m. The distance from Florida Keys to San Francisco is about 2579 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Florida Keys to San Francisco one-way?

    For one-way options, check prices for United Airlines. According to our data, you can fly for as low as $121. Users have also found prices from $121 and $229 on Frontier and Delta, respectively.

  • Can I find deals for flights from Florida Keys to San Francisco that include hotel bookings?

    Yes. In addition to deals on Florida Keys to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to San Francisco.

  • Can I find deals for business class flights from Florida Keys to San Francisco?

    Yes. Cheapflights offers flight deals from Florida Keys to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Florida Keys to San Francisco (average of $276). Flying from Florida Keys to San Francisco in June is currently the most expensive (average of $358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
Santa Cruz
Livermore
South San Francisco
Mountain View
Turlock
Santa Clara
Hollister
Antioch
Watsonville
Manteca
Sunnyvale
Newark
Milpitas
Campbell
Foster City
San Leandro
Burlingame
Redwood City
Vallejo

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Florida Keys to San Francisco

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Top airline flying from Florida Keys to San Francisco

Discover the top airline that operate flights from Florida Keys to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$313Average$446FlexibilityNo cancel feeOn-time71%

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