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$130+ Cheap flights from Key West to San Francisco (EYW - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/6. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Mar 12 — Mar 191
Thu 3/12
Thu 3/19
1 adult, Economy
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Cheap flight deals from Key West to San Francisco

Cheapest flights from Key West to San Francisco
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 10, 2026.

This American Airlines deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/84:20 pm
EYW
-
SFO
1 stop9h 55m
American Airlines
Tue 5/129:08 am
SFO
-
EYW
1 stop9h 45m
American Airlines
Deal found 2/6$259
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:25 pm
EYW
-
SFO
1 stop9h 10m
Delta
Mon 4/1311:39 pm
SFO
-
EYW
1 stop8h 11m
Delta
Deal found 2/9$359
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/192:29 pm
EYW
-
SFO
1 stop8h 02m
American Airlines
Tue 5/2611:49 pm
SFO
-
EYW
1 stop9h 27m
American Airlines
Deal found 2/8$417
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/31:01 pm
EYW
-
SFO
1 stop9h 59m
American Airlines
Wed 6/107:45 am
SFO
-
EYW
1 stop8h 25m
American Airlines
Deal found 2/8$427
This United Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:00 am
EYW
-
SFO
1 stop10h 07m
United Airlines
Mon 3/29:30 pm
SFO
-
EYW
1 stop12h 45m
United Airlines
Deal found 2/7$459
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/63:56 pm
EYW
-
SFO
2 stops11h 52m
American Airlines
Mon 4/136:00 am
SFO
-
EYW
1 stop9h 16m
American Airlines
Deal found 2/9$481
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/133:58 pm
EYW
-
SFO
1 stop10h 03m
American Airlines
Mon 4/206:00 am
SFO
-
EYW
1 stop9h 16m
American Airlines
Deal found 2/9$507

Find flight deals from Key West to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 10, 2026.

Most accurate provider

Expedia
1 star

Most trusted provider

Expedia
3 stars

Round-trip from

$259
(American Airlines)

One-way from

$130
(American Airlines)
Provider with most accurate pricing for Key West-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-San Francisco flights.
Search Deals
From Key West to San Francisco
Search Deals
One-way flight from Key West to San Francisco
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 10, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Fly from

Key West

Fly to

San Francisco

Route

Depart

Return

Price

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 5/8

4:20 pm-11:15 pm

1 stop9h 55m

San Francisco

Tue 5/12

9:08 am-9:53 pm

1 stop9h 45m

$259

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Mon 4/6

6:25 pm-12:35 am

1 stop9h 10m

San Francisco

Mon 4/13

11:39 pm-10:50 am

1 stop8h 11m

$359

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Tue 5/19

2:29 pm-7:31 pm

1 stop8h 02m

San Francisco

Tue 5/26

11:49 pm-12:16 pm

1 stop9h 27m

$417

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 6/3

1:01 pm-8:00 pm

1 stop9h 59m

San Francisco

Wed 6/10

7:45 am-7:10 pm

1 stop8h 25m

$427

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 2/26

6:35 pm-1:28 am

1 stop9h 53m

San Francisco

Mon 3/2

10:55 pm-1:15 pm

1 stop11h 20m

$459

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Mon 4/13

3:58 pm-11:01 pm

1 stop10h 03m

San Francisco

Mon 4/20

6:00 am-6:16 pm

1 stop9h 16m

$507

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 5/6

11:56 am-8:12 pm

1 stop11h 16m

$130

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Thu 5/7

4:20 pm-11:15 pm

1 stop9h 55m

$130

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 5/6

11:46 am-12:52 pm

3 stops28h 06m

$173

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Mon 4/6

9:49 am-7:14 pm

2 stops36h 25m

$193

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/7

  • Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Key West to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Key West to San Francisco?

    American Airlines and Delta can get you from Key West to San Francisco in just under 9h 10m. Your travel time can differ by up to 45m. Key West and San Francisco are separated by a distance of 2542 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Key West to San Francisco that include hotel bookings?

    Yes. In addition to deals on Key West to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Francisco.

  • Can I find deals for business class flights from Key West to San Francisco?

    Yes. Cheapflights offers flight deals from Key West to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Cruz
Santa Clara
Roseville
Livermore
Watsonville
San Bruno
Daly City
Sunnyvale
Turlock
Vacaville
San Carlos
San Ramon
San Lorenzo
Davis
Hollister
Redwood City
Manteca
Union City
Elk Grove

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