$179+ Cheap flights from Key West to San Francisco (EYW - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/16. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Aug 8 — Aug 151
Round-trip
1 adult, Economy
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Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 9, 2026.
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 9, 2026.
This Delta deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:11 pm
EYW
- SFO
1 stop9h 04m
Delta
Sat 10/1011:45 pm
SFO
- EYW
1 stop8h 03m
Delta
Deal found 7/8![Delta logo]()
$330
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:09 pm
EYW
- SFO
1 stop7h 45m
American Airlines
Wed 8/2611:30 pm
SFO
- EYW
2 stops13h 48m
American Airlines
Deal found 7/8![American Airlines logo]()
$417
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:28 pm
EYW
- SFO
1 stop9h 31m
American Airlines
Sat 10/105:30 am
SFO
- EYW
1 stop8h 24m
American Airlines
Deal found 7/8![American Airlines logo]()
$420
This United Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/244:00 pm
EYW
- SFO
1 stop11h 32m
United Airlines
Mon 7/2712:50 am
SFO
- EYW
1 stop11h 29m
United Airlines
Deal found 7/8![United Airlines logo]()
$474
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/281:01 pm
EYW
- SFO
1 stop10h 05m
American Airlines
Sat 8/111:49 pm
SFO
- EYW
1 stop8h 06m
American Airlines
Deal found 7/7![American Airlines logo]()
$476
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/241:47 pm
EYW
- SFO
1 stop9h 33m
American Airlines
Tue 7/2811:20 pm
SFO
- EYW
2 stops10h 54m
American Airlines
Deal found 7/8![American Airlines logo]()
$531
This American Airlines deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2312:55 pm
EYW
- SFO
1 stop10h 56m
American Airlines
Mon 12/286:00 am
SFO
- EYW
1 stop7h 30m
American Airlines
Deal found 7/4![American Airlines logo]()
$609
Best flights from Key West to San FranciscoDiscover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 9, 2026.
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 9, 2026.
This Delta deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:11 pm
EYW
- SFO
1 stop9h 04m
Delta
Sat 10/1011:45 pm
SFO
- EYW
1 stop8h 03m
Delta
Deal found 7/8![Delta logo]()
$330
This American Airlines deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:09 pm
EYW
- SFO
1 stop7h 45m
American Airlines
Tue 8/259:35 pm
SFO
- EYW
1 stop9h 09m
American Airlines
Deal found 7/5![American Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:09 pm
EYW
- SFO
1 stop7h 45m
American Airlines
Wed 8/2611:30 pm
SFO
- EYW
2 stops13h 48m
American Airlines
Deal found 7/8![American Airlines logo]()
$417
This American Airlines deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:28 pm
EYW
- SFO
1 stop9h 31m
American Airlines
Sat 10/1011:27 pm
SFO
- EYW
2 stops10h 36m
American Airlines
Deal found 7/5![American Airlines logo]()
$442
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/241:47 pm
EYW
- SFO
2 stops11h 27m
American Airlines
Tue 7/2811:20 pm
SFO
- EYW
2 stops10h 54m
American Airlines
Deal found 7/8![American Airlines logo]()
$570
This Delta deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:11 pm
EYW
- SFO
1 stop9h 04m
Delta
Fri 11/611:45 pm
SFO
- EYW
1 stop8h 03m
Delta
Deal found 7/9![Delta logo]()
$747
This American Airlines deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2312:55 pm
EYW
- SFO
1 stop10h 56m
American Airlines
Mon 12/286:00 am
SFO
- EYW
1 stop7h 30m
American Airlines
Deal found 7/4![American Airlines logo]()
$609
Last-minute flights from Key West to San FranciscoDiscover last-minute flight deals from Key West to San Francisco. Data last updated July 9, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Francisco. Data last updated July 9, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/244:00 pm
EYW
- SFO
1 stop11h 32m
United Airlines
Mon 7/2712:50 am
SFO
- EYW
1 stop11h 29m
United Airlines
Deal found 7/8![United Airlines logo]()
$474
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/241:47 pm
EYW
- SFO
1 stop9h 33m
American Airlines
Tue 7/2811:20 pm
SFO
- EYW
2 stops10h 54m
American Airlines
Deal found 7/8![American Airlines logo]()
$531
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/281:01 pm
EYW
- SFO
1 stop10h 05m
American Airlines
Sat 8/111:49 pm
SFO
- EYW
1 stop8h 06m
American Airlines
Deal found 7/7![American Airlines logo]()
$476
This Kiwi.com deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/212:05 pm
EYW
- SFO
2 stops31h 06m
Multiple Airlines
Sun 8/912:47 pm
SFO
- EYW
1 stop19h 20m
Multiple Airlines
Deal found 7/5![Multiple Airlines logo]()
$663
This American Airlines deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/24:41 pm
EYW
- SFO
1 stop9h 07m
American Airlines
Sun 8/95:05 am
SFO
- EYW
1 stop10h 39m
American Airlines
Deal found 7/5![American Airlines logo]()
$848
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:09 pm
EYW
- SFO
1 stop7h 45m
American Airlines
Wed 8/267:30 am
SFO
- EYW
1 stop9h 09m
American Airlines
Deal found 7/8![American Airlines logo]()
$330
This United Airlines deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:15 pm
EYW
- SFO
1 stop11h 22m
United Airlines
Tue 8/2510:35 am
SFO
- EYW
2 stops23h 54m
United Airlines
Deal found 7/5![United Airlines logo]()
$1,139
One-way flights from Key West to San FranciscoSearch for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 9, 2026.
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:04 am
EYW
- SFO
2 stops11h 16m
Multiple Airlines
Deal found 7/4![Multiple Airlines logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/173:27 pm
EYW
- SFO
2 stops32h 13m
Multiple Airlines
Deal found 7/5![Multiple Airlines logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/511:46 am
EYW
- SFO
2 stops33h 23m
Multiple Airlines
Deal found 7/6![Multiple Airlines logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/168:48 pm
EYW
- SFO
2 stops39h 00m
Multiple Airlines
Deal found 7/6![Multiple Airlines logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1010:04 am
EYW
- SFO
3 stops35h 16m
Multiple Airlines
Deal found 7/5![Multiple Airlines logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1511:46 am
EYW
- SFO
2 stops24h 02m
Multiple Airlines
Deal found 7/6![Multiple Airlines logo]()
$252
Find flight deals from Key West to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 9, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $330 (Delta) |
One-way from | $179 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 9, 2026.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 10/6
6:11 pm-12:15 am
1 stop9h 04m
San Francisco
Sat 10/10
11:45 pm-10:48 am
1 stop8h 03m
$330
Quickest round-trip
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 8/17
8:09 pm-12:54 am
1 stop7h 45m
San Francisco
Tue 8/25
9:35 pm-9:44 am
1 stop9h 09m
$330
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 8/17
8:09 pm-12:54 am
1 stop7h 45m
San Francisco
Wed 8/26
11:30 pm-4:18 pm
2 stops13h 48m
$417
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Tue 10/6
5:28 pm-11:59 pm
1 stop9h 31m
San Francisco
Sat 10/10
11:27 pm-1:03 pm
2 stops10h 36m
$442
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Fri 7/24
1:47 pm-10:14 pm
2 stops11h 27m
San Francisco
Tue 7/28
11:20 pm-1:14 pm
2 stops10h 54m
$570
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Wed 12/23
12:55 pm-8:51 pm
1 stop10h 56m
San Francisco
Mon 12/28
6:00 am-4:30 pm
1 stop7h 30m
$609
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 11/2
6:11 pm-12:15 am
1 stop9h 04m
San Francisco
Fri 11/6
11:45 pm-10:48 am
1 stop8h 03m
$747
Cheapest one-way
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Mon 8/17
3:27 pm-8:40 pm
2 stops32h 13m
$180
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Wed 8/5
11:46 am-6:09 pm
2 stops33h 23m
$201
Key WestSan Francisco
EYW - SFO
EYWSFO
Key West
Wed 9/16
10:04 am-9:18 pm
3 stops14h 14m
$229
Showing 1-10 of 15 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Key West-San Francisco flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Key West-San Francisco flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Key West-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
EYW-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated July 9, 2026.
See what other customers who have flown with American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Food
6.4
Boarding
7.5
Entertainment
6.8
Comfort
7.2
Overall
7.1
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Crew
7.9
Food
6.4
Boarding
7.5
Entertainment
6.8
Comfort
7.2
Overall
7.1
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Fairfield
Burlingame
Redwood City
Rancho Cordova
Roseville
Cupertino
Emeryville
Newark
San Bruno
Watsonville
Hayward
San Ramon
San Carlos
Turlock
Vallejo
San Lorenzo
Davis
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Key West and San Francisco flights
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Browse through other flights departing from Key West. Flights are based on user searches made on Cheapflights and were last updated on July 9, 2026.
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Top airline flying from Key West to San Francisco
Discover the top airline that operate flights from Key West to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$348 | Average$348 | FlexibilityNo cancel fee | On-time71% |