San Francisco

$140+ Cheap flights from Key West to San Francisco (EYW - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/19. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SFO
Jul 6 — Jul 131
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Cheap flight deals from Key West to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 1, 2025.

Round-trip from

$314
(American Airlines)

One-way from

$140
(American Airlines)
From Key West to San Francisco
One-way flight from Key West to San Francisco

Find flight deals from Key West to San Francisco

Cheapest flights from Key West to San Francisco
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1612:47 pmEYW - SFO
1 stop10h 59mAmerican Airlines
Tue 7/2211:17 pmSFO - EYW
1 stop9h 43mAmerican Airlines
Deal found 6/30$314
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/166:00 pmEYW - SFO
1 stop7h 49mDelta
Mon 7/219:35 pmSFO - EYW
1 stop10h 16mDelta
Deal found 6/30$339
This United Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/152:12 pmEYW - SFO
1 stop12h 32mUnited Airlines
Sat 7/199:15 pmSFO - EYW
1 stop12h 26mUnited Airlines
Deal found 6/30$469

Cheapflights Fare Finder

Customize your flight search to find flights from Key West to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Fly from

Key West

Fly to

San Francisco

Route

Depart

Return

Price

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 7/16

12:47 pm-8:46 pm

1 stop10h 59m

San Francisco

Tue 7/22

11:17 pm-12:00 pm

1 stop9h 43m

$314

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 7/16

6:00 pm-10:49 pm

1 stop7h 49m

San Francisco

Mon 7/21

9:35 pm-10:51 am

1 stop10h 16m

$339

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Tue 7/15

2:12 pm-11:44 pm

1 stop12h 32m

San Francisco

Sat 7/19

9:15 pm-12:41 pm

1 stop12h 26m

$469

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 9/19

3:45 pm-9:50 pm

1 stop9h 05m

$140

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sat 12/6

4:03 pm-12:10 pm

3 stops23h 07m

$573

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Best time to book a flight from Key West to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to San Francisco

What is the cheapest time of day to fly from EYW to SFO?

Find hourly flight availability from Key West to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 1, 2025.

When flying from Key West to San Francisco, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 20% versus a flight at noon.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated July 1, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
8.0
Very good

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
8.0
Very good
8.0
Very good

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
8.0
Very good

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
8.0
Very good

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What are the cheapest airlines flying from Key West to San Francisco round-trip?

    American Airlines, at $314, was found to be the cheapest airline from Key West to San Francisco.Alternate airlines to your destination round-trip include Delta and United Airlines.

  • Can I find deals for flights from Key West to San Francisco that include hotel bookings?

    Yes. In addition to deals on Key West to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Francisco.

  • Can I find deals for business class flights from Key West to San Francisco?

    Yes. Cheapflights offers flight deals from Key West to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key West to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Key West to San Francisco (average of $276). Flying from Key West to San Francisco in June is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Roseville
Mountain View
South San Francisco
Livermore
Santa Cruz
Turlock
Manteca
Watsonville
Fairfield
Antioch
Hollister
Milpitas
Sunnyvale
Newark
Alameda
Hayward
Daly City
Campbell
Capitola
Foster City

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Key West to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Key West to San Francisco

Discover the top airline that operate flights from Key West to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$313Average$508FlexibilityNo cancel feeOn-time71%

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