What are the cheapest airlines flying from Key West to San Francisco round-trip?

American Airlines, at $314, was found to be the cheapest airline from Key West to San Francisco.Alternate airlines to your destination round-trip include Delta and United Airlines.

What is the cheapest month to book a flight from Key West to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Key West to San Francisco (average of $276). Flying from Key West to San Francisco in June is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest day to fly from Key West to San Francisco?

Travelers seeking maximum savings on their Key West to San Francisco flight should consider departing on Friday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What is the cheapest day to fly round-trip from Key West to San Francisco?

Friday is generally a great day to depart. Flying on this day could help you save up to 56%.

Can I find deals for flights from Key West to San Francisco that include hotel bookings?

Yes. In addition to deals on Key West to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Key West to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Francisco.

Can I find deals for business class flights from Key West to San Francisco?

Yes. Cheapflights offers flight deals from Key West to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$140+ Flights from Key West to San Francisco

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Cheap flight deals from Key West to San Francisco

Round-trip from	$314 (American Airlines)
One-way from	$140 (American Airlines)

From Key West to San Francisco

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One-way flight from Key West to San Francisco

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Find flight deals from Key West to San Francisco

Cheapest flights from Key West to San Francisco
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Wed 7/1612:47 pmEYW - SFO

1 stop10h 59mAmerican Airlines

Tue 7/2211:17 pmSFO - EYW

1 stop9h 43mAmerican Airlines

Deal found 6/30

$314

Wed 7/166:00 pmEYW - SFO

1 stop7h 49mDelta

Mon 7/219:35 pmSFO - EYW

1 stop10h 16mDelta

Deal found 6/30

$339

Tue 7/152:12 pmEYW - SFO

1 stop12h 32mUnited Airlines

Sat 7/199:15 pmSFO - EYW

1 stop12h 26mUnited Airlines

Deal found 6/30

$469

Best flights from Key West to San Francisco
Discover carefully curated flight deals from Key West to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 1, 2025.

Wed 7/1612:47 pmEYW - SFO

1 stop10h 59mAmerican Airlines

Tue 7/2211:17 pmSFO - EYW

1 stop9h 43mAmerican Airlines

Deal found 6/30

$314

Wed 7/166:00 pmEYW - SFO

1 stop7h 49mDelta

Mon 7/219:35 pmSFO - EYW

1 stop10h 16mDelta

Deal found 6/30

$339

Tue 7/152:12 pmEYW - SFO

1 stop12h 32mUnited Airlines

Sat 7/199:15 pmSFO - EYW

1 stop12h 26mUnited Airlines

Deal found 6/30

$469

Last-minute flights from Key West to San Francisco
Discover last-minute flight deals from Key West to San Francisco. Data last updated July 1, 2025 and is based on user searches.

Wed 7/96:00 pmEYW - SFO

1 stop7h 49mDelta

Wed 7/166:15 amSFO - EYW

1 stop10h 34mDelta

Deal found 6/30

$413

Thu 7/1012:47 pmEYW - SFO

2 stops10h 39mAmerican Airlines

Mon 7/145:41 amSFO - EYW

1 stop7h 31mAmerican Airlines

Deal found 6/30

$419

Thu 7/102:12 pmEYW - SFO

1 stop12h 32mUnited Airlines

Sat 7/124:25 pmSFO - EYW

2 stops17h 16mUnited Airlines

Deal found 6/30

$693

Thu 7/1010:02 amEYW - SFO

3 stops52h 37mBreeze Airways

Tue 7/1512:33 pmSFO - EYW

3 stops41h 49mBreeze Airways

Deal found 6/30

$1,001

Tue 7/152:12 pmEYW - SFO

1 stop12h 32mUnited Airlines

Sat 7/199:15 pmSFO - EYW

1 stop12h 26mUnited Airlines

Deal found 6/30

$469

Wed 7/1612:47 pmEYW - SFO

1 stop10h 59mAmerican Airlines

Tue 7/2211:17 pmSFO - EYW

1 stop9h 43mAmerican Airlines

Deal found 6/30

$314

Wed 7/166:00 pmEYW - SFO

1 stop7h 49mDelta

Mon 7/219:35 pmSFO - EYW

1 stop10h 16mDelta

Deal found 6/30

$339

One-way flights from Key West to San Francisco
Search for one-way flight options from Key West to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 1, 2025.

Fri 9/193:45 pmEYW - SFO

1 stop9h 05mAmerican Airlines

Deal found 6/30

$140

Sat 12/64:03 pmEYW - SFO

3 stops23h 07mUnited Airlines

Deal found 6/30

$573

Cheapflights Fare Finder

Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 7/16

12:47 pm-8:46 pm

1 stop10h 59m

San Francisco

Tue 7/22

11:17 pm-12:00 pm

1 stop9h 43m

$314

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Wed 7/16

6:00 pm-10:49 pm

1 stop7h 49m

San Francisco

Mon 7/21

9:35 pm-10:51 am

1 stop10h 16m

$339

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Tue 7/15

2:12 pm-11:44 pm

1 stop12h 32m

San Francisco

Sat 7/19

9:15 pm-12:41 pm

1 stop12h 26m

$469

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Fri 9/19

3:45 pm-9:50 pm

1 stop9h 05m

$140

Key WestSan Francisco

EYW - SFO

EYWSFO

Key West

Sat 12/6

4:03 pm-12:10 pm

3 stops23h 07m

$573

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Best time to book a flight from Key West to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to San Francisco

What is the cheapest time of day to fly from EYW to SFO?

When flying from Key West to San Francisco, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 20% versus a flight at noon.

Reviews of airlines servicing San Francisco

See what other customers who have flown with Delta, United Airlines, and American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,973 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta

8.0

Very good

7,973 reviews

Delta

8.0

Very good

7,973 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines

7.4

Good

8,858 reviews

Delta

8.0

Very good

7,973 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,973 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

What are the cheapest airlines flying from Key West to San Francisco round-trip?
American Airlines, at $314, was found to be the cheapest airline from Key West to San Francisco.Alternate airlines to your destination round-trip include Delta and United Airlines.
Can I find deals for flights from Key West to San Francisco that include hotel bookings?
Yes. In addition to deals on Key West to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Key West to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to San Francisco.
Can I find deals for business class flights from Key West to San Francisco?
Yes. Cheapflights offers flight deals from Key West to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Key West to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Key West to San Francisco (average of $276). Flying from Key West to San Francisco in June is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Roseville

Mountain View

South San Francisco

Livermore

Santa Cruz

Turlock

Manteca

Watsonville

Fairfield

Antioch

Hollister

Milpitas

Sunnyvale

Newark

Alameda

Hayward

Daly City

Campbell

Capitola

Foster City

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Key West to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$313	Average$508	FlexibilityNo cancel fee	On-time71%

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$140+ Cheap flights from Key West to San Francisco (EYW - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/19. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Key West to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Key West to San Francisco

Round-trip from

One-way from

Find flight deals from Key West to San Francisco

Cheapest flights from Key West to San FranciscoExplore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Key West to San Francisco that are best for you.

Best time to book a flight from Key West to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Key West with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Key West to San Francisco

What is the cheapest time of day to fly from EYW to SFO?

Find hourly flight availability from Key West to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 1, 2025.

Reviews of airlines servicing San Francisco

See what other customers who have flown with Delta, United Airlines, and American Airlines from Key West to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Key West to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Key West to San Francisco round-trip?

Can I find deals for flights from Key West to San Francisco that include hotel bookings?

How can I find direct flights from Key West to San Francisco?

Can I find deals for business class flights from Key West to San Francisco?

What is the cheapest month to book a flight from Key West to San Francisco?

Traveling to a place near Key West?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Key West to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Key West to San Francisco

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Key West to San Francisco
Explore the most affordable flight options available from Key West to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.