$259+ Cheap flights from Odessa, TX to San Diego (SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/4. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — SAN
Oct 16 — Oct 231
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
Last-minute
One-way
Cheapest flights from Odessa to San DiegoExplore the most affordable flight options available from Odessa to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2026.
Explore the most affordable flight options available from Odessa to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2026.
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:15 pm -
1 stop5h 55m
Tue 10/203:00 pm -
1 stop5h 55m
Deal found 9/10![Southwest logo]()
$325
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/78:07 pm -
1 stop5h 31m
Wed 10/144:26 pm -
1 stop5h 33m
Deal found 9/13![American Airlines logo]()
$427
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:07 pm -
1 stop5h 31m
Mon 10/124:29 pm -
1 stop5h 28m
Deal found 9/15![American Airlines logo]()
$436
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/262:23 pm -
1 stop7h 38m
Wed 9/3012:08 pm -
1 stop7h 11m
Deal found 9/11![American Airlines logo]()
$497
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2611:30 am -
1 stop6h 05m
Wed 9/3011:30 am -
2 stops7h 05m
Deal found 9/11![Southwest logo]()
$522
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:25 pm -
1 stop5h 30m
Mon 10/128:40 am -
2 stops12h 35m
Deal found 9/15![Southwest logo]()
$549
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:55 am -
2 stops7h 40m
Mon 10/128:40 am -
2 stops12h 35m
Deal found 9/15![Southwest logo]()
$554
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/227:00 am -
1 stop8h 17m
Wed 9/2312:37 pm -
1 stop7h 32m
Deal found 9/14![United Airlines logo]()
$557
Best flights from Odessa to San DiegoDiscover carefully curated flight deals from Odessa to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2026.
Discover carefully curated flight deals from Odessa to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2026.
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:07 pm -
1 stop5h 31m
Mon 10/124:29 pm -
1 stop5h 28m
Deal found 9/15![American Airlines logo]()
$436
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2611:30 am -
1 stop6h 05m
Wed 9/3011:30 am -
2 stops7h 05m
Deal found 9/11![Southwest logo]()
$522
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/71:41 pm -
1 stop5h 24m
Wed 10/147:41 pm -
2 stops15h 04m
Deal found 9/13![United Airlines logo]()
$635
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2812:55 pm -
1 stop7h 10m
Fri 10/21:05 pm -
2 stops7h 10m
Deal found 9/13![Southwest logo]()
$522
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:25 pm -
1 stop5h 30m
Mon 10/128:40 am -
2 stops12h 35m
Deal found 9/15![Southwest logo]()
$549
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:55 am -
2 stops7h 40m
Mon 10/128:40 am -
2 stops12h 35m
Deal found 9/15![Southwest logo]()
$554
Last-minute flights from Odessa to San DiegoDiscover last-minute flight deals from Odessa to San Diego. Data last updated September 16, 2026 and is based on user searches.
Discover last-minute flight deals from Odessa to San Diego. Data last updated September 16, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/227:00 am -
1 stop8h 17m
Wed 9/2312:37 pm -
1 stop7h 32m
Deal found 9/14![United Airlines logo]()
$557
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/262:23 pm -
1 stop7h 38m
Wed 9/3012:08 pm -
1 stop7h 11m
Deal found 9/11![American Airlines logo]()
$497
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2611:30 am -
1 stop6h 05m
Wed 9/3011:30 am -
2 stops7h 05m
Deal found 9/11![Southwest logo]()
$522
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/78:07 pm -
1 stop5h 31m
Wed 10/144:26 pm -
1 stop5h 33m
Deal found 9/13![American Airlines logo]()
$427
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:55 am -
2 stops7h 40m
Mon 10/128:40 am -
2 stops12h 35m
Deal found 9/15![Southwest logo]()
$554
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:07 pm -
1 stop5h 31m
Mon 10/124:29 pm -
1 stop5h 28m
Deal found 9/15![American Airlines logo]()
$436
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:25 pm -
1 stop5h 30m
Mon 10/128:40 am -
2 stops12h 35m
Deal found 9/15![Southwest logo]()
$549
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:15 pm -
1 stop5h 55m
Tue 10/203:00 pm -
1 stop5h 55m
Deal found 9/10![Southwest logo]()
$325
One-way flights from Odessa to San DiegoSearch for one-way flight options from Odessa to San Diego. Find affordable one-way fares based on user searches. Data last updated September 16, 2026.
Search for one-way flight options from Odessa to San Diego. Find affordable one-way fares based on user searches. Data last updated September 16, 2026.
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/45:00 am -
1 stop7h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![United Airlines logo]()
$259
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:15 am -
2 stops7h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Southwest logo]()
$275
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:23 pm -
1 stop6h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![American Airlines logo]()
$574
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1811:54 am -
2 stops10h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![United Airlines logo]()
$1,254
Find flight deals from Odessa to San Diego
Keep the following information in mind while searching for Odessa to San Diego flight deals. Data was last updated September 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $325 (Southwest) |
One-way from | $259 (United Airlines) |
Popular in | December |
Cheapest in | March |
Average price | $316 |
Cheapflights Fare Finder
Customize your flight search to find flights from Odessa to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 16, 2026.
Use the filters below to find and compare flights from Odessa to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
MidlandSan Diego
MAF Midland Intl - SAN San Diego
MAFSAN
Midland Intl
Sun 10/4
5:00 am-10:58 am
1 stop7h 58m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$259
Quickest round-trip
MidlandSan Diego
MAF Midland Intl - SAN San Diego
MAFSAN
Midland Intl
Sun 10/4
6:15 am-11:50 am
2 stops7h 35m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$275
MidlandSan Diego
MAF Midland Intl - SAN San Diego
MAFSAN
Midland Intl
Fri 10/9
8:07 pm-11:38 pm
1 stop5h 31m
San Diego
Mon 10/12
4:29 pm-11:57 pm
1 stop5h 28m
$436
MidlandSan Diego
MAF Midland Intl - SAN San Diego
MAFSAN
Midland Intl
Sat 9/26
11:30 am-3:35 pm
1 stop6h 05m
San Diego
Wed 9/30
11:30 am-8:35 pm
2 stops7h 05m
$522
MidlandSan Diego
MAF Midland Intl - SAN San Diego
MAFSAN
Midland Intl
Mon 9/28
12:55 pm-6:05 pm
1 stop7h 10m
San Diego
Fri 10/2
1:05 pm-10:15 pm
2 stops7h 10m
$522
MidlandSan Diego
MAF Midland Intl - SAN San Diego
MAFSAN
Midland Intl
Fri 10/9
8:25 pm-11:55 pm
1 stop5h 30m
San Diego
Mon 10/12
8:40 am-11:15 pm
2 stops12h 35m
$549
MidlandSan Diego
MAF Midland Intl - SAN San Diego
MAFSAN
Midland Intl
Thu 10/8
6:55 am-12:35 pm
2 stops7h 40m
San Diego
Mon 10/12
8:40 am-11:15 pm
2 stops12h 35m
$554
MidlandSan Diego
MAF Midland Intl - SAN San Diego
MAFSAN
Midland Intl
Wed 10/7
1:41 pm-5:05 pm
1 stop5h 24m
San Diego
Wed 10/14
7:41 pm-12:45 pm
2 stops15h 04m
$635
Sorted by cheapest first
Best time to book a flight from Odessa to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Odessa with our price prediction graph.
MAF-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Odessa to San Diego
OD3-SAN
MAF-SAN
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated September 16, 2026.
Read through reviews of airlines operating flights from Odessa to San Diego, such as Southwest and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Odessa to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
Coronado
San Ysidro
Poway
La Mesa
Santee
Julian
Lemon Grove
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Odessa to San Diego
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Complete your trip
Complete your trip to San Diego by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Odessa to San Diego by cabin class
Find flights from Odessa to San Diego, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Odessa and San Diego flights
Browse other Odessa and San Diego flight options. Last updated on September 16, 2026.
Popular flight searches
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Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 16, 2026.
Odessa to San Diego flights
Consider these flights traveling from Odessa to San Diego.
Top 2 airlines flying from Odessa to San Diego
Discover the top 2 airlines that operate flights from Odessa to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$284 | Average$379 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$416 | FlexibilityNo cancel fee | On-time63% |