$163+ Cheap flights from Odessa, TX to San Diego (SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/16. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — SAN
Sep 1 — Sep 81
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
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Cheapest flights from Odessa to San DiegoExplore the most affordable flight options available from Odessa to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 2, 2026.
Explore the most affordable flight options available from Odessa to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 2, 2026.
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:25 pm
MAF
- SAN
1 stop5h 40m
Southwest
Tue 8/252:10 pm
SAN
- MAF
1 stop4h 20m
Southwest
Deal found 7/30![Southwest logo]()
$325
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:07 pm
MAF
- SAN
1 stop5h 31m
American Airlines
Sat 11/74:30 pm
SAN
- MAF
1 stop4h 22m
American Airlines
Deal found 7/31![American Airlines logo]()
$338
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:55 pm
MAF
- SAN
2 stops8h 35m
Southwest
Sat 11/711:55 am
SAN
- MAF
1 stop7h 30m
Southwest
Deal found 7/31![Southwest logo]()
$376
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/151:55 pm
MAF
- SAN
1 stop7h 10m
Southwest
Sun 10/184:05 pm
SAN
- MAF
1 stop5h 40m
Southwest
Deal found 8/2![Southwest logo]()
$394
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:00 am
MAF
- SAN
1 stop8h 24m
United Airlines
Wed 11/43:04 pm
SAN
- MAF
1 stop6h 39m
United Airlines
Deal found 7/28![United Airlines logo]()
$405
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:30 am
MAF
- SAN
1 stop5h 50m
Southwest
Sun 10/184:05 pm
SAN
- MAF
1 stop5h 40m
Southwest
Deal found 8/2![Southwest logo]()
$411
Best flights from Odessa to San DiegoDiscover carefully curated flight deals from Odessa to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 2, 2026.
Discover carefully curated flight deals from Odessa to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 2, 2026.
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:25 pm
MAF
- SAN
1 stop5h 40m
Southwest
Tue 8/252:10 pm
SAN
- MAF
1 stop4h 20m
Southwest
Deal found 7/30![Southwest logo]()
$325
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/39:41 am
MAF
- SAN
1 stop5h 43m
United Airlines
Wed 11/412:05 pm
SAN
- MAF
1 stop7h 43m
United Airlines
Deal found 7/29![United Airlines logo]()
$405
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/151:55 pm
MAF
- SAN
2 stops8h 35m
Southwest
Sun 10/184:05 pm
SAN
- MAF
1 stop5h 40m
Southwest
Deal found 8/2![Southwest logo]()
$399
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:30 am
MAF
- SAN
1 stop5h 50m
Southwest
Sun 10/184:05 pm
SAN
- MAF
1 stop5h 40m
Southwest
Deal found 8/2![Southwest logo]()
$411
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/205:50 am
MAF
- SAN
1 stop7h 20m
Southwest
Mon 8/246:20 am
SAN
- MAF
1 stop8h 35m
Southwest
Deal found 7/31![Southwest logo]()
$424
Last-minute flights from Odessa to San DiegoDiscover last-minute flight deals from Odessa to San Diego. Data last updated August 2, 2026 and is based on user searches.
Discover last-minute flight deals from Odessa to San Diego. Data last updated August 2, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:00 am
MAF
- SAN
1 stop6h 05m
American Airlines
Mon 8/31:55 pm
SAN
- MAF
1 stop7h 08m
American Airlines
Deal found 7/30![American Airlines logo]()
$997
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/311:30 pm
MAF
- SAN
2 stops8h 45m
Southwest
Mon 8/36:20 am
SAN
- MAF
1 stop5h 35m
Southwest
Deal found 7/30![Southwest logo]()
$1,002
This Southwest deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/166:15 pm
MAF
- SAN
1 stop5h 00m
Southwest
Mon 8/172:55 pm
SAN
- MAF
1 stop6h 40m
Southwest
Deal found 8/1![Southwest logo]()
$492
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:25 pm
MAF
- SAN
1 stop5h 40m
Southwest
Tue 8/252:10 pm
SAN
- MAF
1 stop4h 20m
Southwest
Deal found 7/30![Southwest logo]()
$325
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/205:50 am
MAF
- SAN
1 stop7h 20m
Southwest
Mon 8/246:20 am
SAN
- MAF
1 stop8h 35m
Southwest
Deal found 7/31![Southwest logo]()
$424
One-way flights from Odessa to San DiegoSearch for one-way flight options from Odessa to San Diego. Find affordable one-way fares based on user searches. Data last updated August 2, 2026.
Search for one-way flight options from Odessa to San Diego. Find affordable one-way fares based on user searches. Data last updated August 2, 2026.
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:00 am
MAF
- SAN
1 stop5h 18m
American Airlines
Deal found 7/30![American Airlines logo]()
$163
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:20 am
MAF
- SAN
2 stops7h 20m
Southwest
Deal found 7/30![Southwest logo]()
$168
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/213:10 pm
MAF
- SAN
1 stop5h 35m
Southwest
Deal found 7/30![Southwest logo]()
$193
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/53:05 pm
MAF
- SAN
2 stops6h 50m
Southwest
Deal found 7/30![Southwest logo]()
$208
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/138:00 am
MAF
- SAN
1 stop7h 25m
Southwest
Deal found 7/29![Southwest logo]()
$249
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/167:40 am
MAF
- SAN
2 stops12h 55m
United Airlines
Deal found 7/29![United Airlines logo]()
$284
This Southwest deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/107:05 am
MAF
- SAN
1 stop5h 30m
Southwest
Deal found 8/1![Southwest logo]()
$394
Find flight deals from Odessa to San Diego
Keep the following information in mind while searching for Odessa to San Diego flight deals. Data was last updated August 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $325 (Southwest) |
One-way from | $163 (American Airlines) |
Popular in | December |
Cheapest in | March |
Average price | $367 |
Cheapflights Fare Finder
Customize your flight search to find flights from Odessa to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 2, 2026.
Use the filters below to find and compare flights from Odessa to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Thu 8/20
6:25 pm-10:05 pm
1 stop5h 40m
San Diego
Tue 8/25
2:10 pm-8:30 pm
1 stop4h 20m
$325
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Thu 10/15
1:55 pm-8:30 pm
2 stops8h 35m
San Diego
Sun 10/18
4:05 pm-11:45 pm
1 stop5h 40m
$399
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Tue 11/3
9:41 am-1:24 pm
1 stop5h 43m
San Diego
Wed 11/4
12:05 pm-9:48 pm
1 stop7h 43m
$405
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Fri 10/16
5:30 am-9:20 am
1 stop5h 50m
San Diego
Sun 10/18
4:05 pm-11:45 pm
1 stop5h 40m
$411
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Thu 8/20
5:50 am-11:10 am
1 stop7h 20m
San Diego
Mon 8/24
6:20 am-4:55 pm
1 stop8h 35m
$424
Cheapest one-way
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Wed 9/16
5:00 am-8:18 am
1 stop5h 18m
$163
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Mon 8/24
5:35 pm-9:55 pm
1 stop6h 20m
$163
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Sat 8/22
5:55 am-12:05 pm
1 stop8h 10m
$163
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Fri 8/21
3:10 pm-6:45 pm
1 stop5h 35m
$193
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Fri 11/6
3:05 pm-7:50 pm
2 stops6h 45m
$198
Showing 1-10 of 12 resultsSorted by cheapest first
Best time to book a flight from Odessa to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Odessa with our price prediction graph.
MAF-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Odessa to San Diego
OD3-SAN
MAF-SAN
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated August 2, 2026.
Read through reviews of airlines operating flights from Odessa to San Diego, such as Southwest and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Odessa to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
Poway
La Mesa
Coronado
Santee
San Ysidro
Julian
Lemon Grove
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Alternative routes for Odessa to San Diego
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Odessa and San Diego flights
Browse other Odessa and San Diego flight options. Last updated on August 2, 2026.
Popular flight searches
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Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 2, 2026.
Odessa to San Diego flights
Consider these flights traveling from Odessa to San Diego.
Top 2 airlines flying from Odessa to San Diego
Discover the top 2 airlines that operate flights from Odessa to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$249 | Average$379 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$416 | FlexibilityNo cancel fee | On-time63% |