$183+ Cheap flights from Odessa, TX to San Diego (SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/6. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — SAN
Jun 3 — Jun 101
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Odessa to San DiegoExplore the most affordable flight options available from Odessa to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 4, 2026.
Explore the most affordable flight options available from Odessa to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 4, 2026.
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:20 pm
MAF
- SAN
1 stop5h 55m
Southwest
Wed 6/106:40 am
SAN
- MAF
1 stop7h 40m
Southwest
Deal found 5/3![Southwest logo]()
$335
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/38:23 pm
MAF
- SAN
1 stop5h 36m
American Airlines
Sat 6/64:36 pm
SAN
- MAF
1 stop5h 23m
American Airlines
Deal found 5/1![American Airlines logo]()
$350
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:20 am
MAF
- SAN
1 stop6h 45m
Southwest
Tue 6/166:40 am
SAN
- MAF
1 stop7h 40m
Southwest
Deal found 5/3![Southwest logo]()
$371
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:46 pm
MAF
- SAN
1 stop5h 53m
American Airlines
Thu 6/43:10 pm
SAN
- MAF
1 stop6h 49m
American Airlines
Deal found 5/1![American Airlines logo]()
$386
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:23 pm
MAF
- SAN
1 stop5h 36m
American Airlines
Fri 5/298:05 am
SAN
- MAF
1 stop6h 48m
American Airlines
Deal found 4/30![American Airlines logo]()
$402
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/283:50 pm
MAF
- SAN
1 stop7h 15m
Southwest
Fri 5/2912:40 pm
SAN
- MAF
1 stop7h 05m
Southwest
Deal found 4/30![Southwest logo]()
$407
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/41:30 pm
MAF
- SAN
1 stop7h 35m
Southwest
Mon 6/86:20 am
SAN
- MAF
1 stop5h 35m
Southwest
Deal found 5/3![Southwest logo]()
$412
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/22:15 pm
MAF
- SAN
1 stop7h 35m
United Airlines
Wed 6/36:35 am
SAN
- MAF
1 stop8h 01m
United Airlines
Deal found 4/29![United Airlines logo]()
$415
Best flights from Odessa to San DiegoDiscover carefully curated flight deals from Odessa to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 4, 2026.
Discover carefully curated flight deals from Odessa to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 4, 2026.
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:20 pm
MAF
- SAN
1 stop5h 55m
Southwest
Wed 6/106:40 am
SAN
- MAF
1 stop7h 40m
Southwest
Deal found 5/3![Southwest logo]()
$335
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:00 am
MAF
- SAN
1 stop7h 51m
United Airlines
Wed 6/310:55 am
SAN
- MAF
1 stop6h 44m
United Airlines
Deal found 5/3![United Airlines logo]()
$415
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:20 pm
MAF
- SAN
1 stop5h 40m
Southwest
Sat 6/611:40 am
SAN
- MAF
2 stops8h 50m
Southwest
Deal found 5/1![Southwest logo]()
$402
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:10 pm
MAF
- SAN
1 stop5h 20m
Southwest
Tue 7/286:40 am
SAN
- MAF
1 stop6h 00m
Southwest
Deal found 4/30![Southwest logo]()
$407
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:05 pm
MAF
- SAN
1 stop5h 45m
Southwest
Mon 6/224:25 pm
SAN
- MAF
1 stop5h 40m
Southwest
Deal found 5/3![Southwest logo]()
$407
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:05 pm
MAF
- SAN
1 stop5h 45m
Southwest
Mon 6/89:55 pm
SAN
- MAF
2 stops12h 40m
Southwest
Deal found 5/3![Southwest logo]()
$417
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/293:35 pm
MAF
- SAN
2 stops7h 50m
Southwest
Fri 6/53:15 pm
SAN
- MAF
1 stop5h 50m
Southwest
Deal found 4/29![Southwest logo]()
$422
Last-minute flights from Odessa to San DiegoDiscover last-minute flight deals from Odessa to San Diego. Data last updated May 4, 2026 and is based on user searches.
Discover last-minute flight deals from Odessa to San Diego. Data last updated May 4, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/143:50 pm
MAF
- SAN
1 stop7h 15m
Southwest
Mon 5/184:25 pm
SAN
- MAF
1 stop4h 45m
Southwest
Deal found 4/29![Southwest logo]()
$482
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/178:24 pm
MAF
- SAN
1 stop5h 32m
American Airlines
Fri 5/2212:20 pm
SAN
- MAF
1 stop5h 31m
American Airlines
Deal found 4/30![American Airlines logo]()
$461
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2011:45 am
MAF
- SAN
1 stop8h 05m
Southwest
Sun 5/312:10 pm
SAN
- MAF
2 stops7h 20m
Southwest
Deal found 4/29![Southwest logo]()
$427
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:23 pm
MAF
- SAN
1 stop5h 36m
American Airlines
Fri 5/298:05 am
SAN
- MAF
1 stop6h 48m
American Airlines
Deal found 4/30![American Airlines logo]()
$402
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/283:50 pm
MAF
- SAN
1 stop7h 15m
Southwest
Fri 5/2912:40 pm
SAN
- MAF
1 stop7h 05m
Southwest
Deal found 4/30![Southwest logo]()
$407
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:46 pm
MAF
- SAN
1 stop5h 53m
American Airlines
Thu 6/43:10 pm
SAN
- MAF
1 stop6h 49m
American Airlines
Deal found 5/1![American Airlines logo]()
$386
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/293:35 pm
MAF
- SAN
2 stops7h 50m
Southwest
Fri 6/53:15 pm
SAN
- MAF
1 stop5h 50m
Southwest
Deal found 4/29![Southwest logo]()
$422
One-way flights from Odessa to San DiegoSearch for one-way flight options from Odessa to San Diego. Find affordable one-way fares based on user searches. Data last updated May 4, 2026.
Search for one-way flight options from Odessa to San Diego. Find affordable one-way fares based on user searches. Data last updated May 4, 2026.
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:47 pm
MAF
- SAN
1 stop5h 52m
American Airlines
Deal found 4/29![American Airlines logo]()
$183
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:23 pm
MAF
- SAN
1 stop5h 36m
American Airlines
Deal found 4/30![American Airlines logo]()
$199
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:00 am
MAF
- SAN
1 stop8h 21m
United Airlines
Deal found 4/30![United Airlines logo]()
$204
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/63:20 pm
MAF
- SAN
2 stops8h 00m
Southwest
Deal found 4/29![Southwest logo]()
$209
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/281:00 pm
MAF
- SAN
2 stops11h 35m
Southwest
Deal found 4/30![Southwest logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:00 am
MAF
- SAN
3 stops34h 10m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$910
Find flight deals from Odessa to San Diego
Keep the following information in mind while searching for Odessa to San Diego flight deals. Data was last updated May 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $335 (Southwest) |
One-way from | $183 (American Airlines) |
Popular in | December |
Cheapest in | March |
Average price | $411 |
Cheapflights Fare Finder
Customize your flight search to find flights from Odessa to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 4, 2026.
Use the filters below to find and compare flights from Odessa to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Wed 6/3
2:20 pm-6:15 pm
1 stop5h 55m
San Diego
Wed 6/10
6:40 am-4:20 pm
1 stop7h 40m
$335
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Wed 6/3
6:20 pm-10:00 pm
1 stop5h 40m
San Diego
Sat 6/6
11:40 am-10:30 pm
2 stops8h 50m
$402
Quickest round-trip
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Wed 7/22
6:10 pm-9:30 pm
1 stop5h 20m
San Diego
Tue 7/28
6:40 am-2:40 pm
1 stop6h 00m
$407
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Fri 6/19
6:05 pm-9:50 pm
1 stop5h 45m
San Diego
Mon 6/22
4:25 pm-12:05 am
1 stop5h 40m
$407
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Tue 6/2
5:00 am-10:51 am
1 stop7h 51m
San Diego
Wed 6/3
10:55 am-7:39 pm
1 stop6h 44m
$415
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Thu 6/4
6:05 pm-9:50 pm
1 stop5h 45m
San Diego
Mon 6/8
9:55 pm-12:35 pm
2 stops12h 40m
$417
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Fri 5/29
3:35 pm-9:25 pm
2 stops7h 50m
San Diego
Fri 6/5
3:15 pm-11:05 pm
1 stop5h 50m
$422
Cheapest one-way
Quickest one-way
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Sat 6/6
6:47 pm-10:39 pm
1 stop5h 52m
$183
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Sat 6/6
4:45 pm-10:20 pm
2 stops7h 35m
$209
MidlandSan Diego
MAF - SAN
MAFSAN
Midland Intl
Thu 5/28
1:00 pm-10:35 pm
2 stops11h 35m
$215
Sorted by cheapest first
Best time to book a flight from Odessa to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Odessa with our price prediction graph.
MAF-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Odessa to San Diego
OD3-SAN
MAF-SAN
How much does it cost to fly round-trip from Odessa to San Diego?
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated May 4, 2026.
Read through reviews of airlines operating flights from Odessa to San Diego, such as Southwest and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Food
7.0
Overall
7.9
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Food
7.0
Overall
7.9
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Food
7.0
Overall
7.9
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Odessa to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
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Odessa and San Diego flights
Browse other Odessa and San Diego flight options. Last updated on May 4, 2026.
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Odessa to San Diego flights
Consider these flights traveling from Odessa to San Diego.
Top 2 airlines flying from Odessa to San Diego
Discover the top 2 airlines that operate flights from Odessa to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$226 | Average$379 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$392 | FlexibilityNo cancel fee | On-time63% |