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$129+ Cheap flights from Key Largo, FL to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/24. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — SAN
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to San Diego are usually found in April or May, booked 74 days in advance, depart on a Wednesday or Thursday and return on a Wednesday

Cheap flight deals from Key Largo to San Diego

Keep the following information in mind while searching for Key Largo to San Diego flight deals. Data was last updated September 11, 2025.

Round-trip from

$217
(American Airlines)

One-way from

$129
(Delta)

Popular in

June

Cheapest in

April

Average price

$393
From Key Largo to San Diego
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One-way flight from Key Largo to San Diego
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Highest demand for flights based on searches. 3% potential increase in price ($14 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Key Largo to San Diego

Cheapest flights from Key Largo to San Diego
Explore the most affordable flight options available from Key Largo to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/89:00 amMIA - SAN
Nonstop5h 26mAmerican Airlines
Sat 10/1112:30 pmSAN - MIA
Nonstop4h 53mAmerican Airlines
Deal found 9/9$217
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/249:00 amMIA - SAN
Nonstop5h 26mAmerican Airlines
Fri 10/3112:30 pmSAN - MIA
Nonstop4h 53mAmerican Airlines
Deal found 9/8$218
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/247:20 pmMIA - SAN
1 stop15h 09mMultiple Airlines
Sun 9/288:25 amSAN - MIA
2 stops35h 35mMultiple Airlines
Deal found 9/10$219
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:00 amMIA - SAN
1 stop20h 53mMultiple Airlines
Mon 10/612:43 pmSAN - MIA
2 stops26h 28mMultiple Airlines
Deal found 9/10$220
This Cheapflightsfares deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/247:20 pmMIA - SAN
1 stop15h 09mSpirit Airlines
Mon 9/296:15 amSAN - MIA
1 stop9h 40mSpirit Airlines
Deal found 9/11$221
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:00 amMIA - SAN
1 stop8h 17mFrontier
Mon 11/36:25 amSAN - MIA
1 stop7h 30mFrontier
Deal found 9/9$222
This Frontier deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/610:30 amMIA - SAN
1 stop14h 44mFrontier
Mon 11/106:25 amSAN - MIA
2 stops15h 09mFrontier
Deal found 9/9$223
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/66:00 amMIA - SAN
1 stop8h 09mMultiple Airlines
Mon 10/66:49 pmSAN - MIA
1 stop11h 05mMultiple Airlines
Deal found 9/10$224
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/286:00 amMIA - SAN
2 stops28h 29mMultiple Airlines
Tue 9/301:35 pmSAN - MIA
1 stop26h 20mMultiple Airlines
Deal found 9/10$225
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/249:00 amMIA - SAN
2 stops14h 08mFrontier
Sun 10/266:41 amSAN - MIA
1 stop20h 38mFrontier
Deal found 9/10$226
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/267:23 pmMIA - SAN
1 stop15h 06mMultiple Airlines
Sat 10/47:15 amSAN - MIA
1 stop14h 29mMultiple Airlines
Deal found 9/9$227
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/610:30 amMIA - SAN
2 stops29h 05mMultiple Airlines
Wed 11/126:41 amSAN - MIA
1 stop20h 38mMultiple Airlines
Deal found 9/9$228

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Key Largo to San Diego that are best for you.

Fly from

Key Largo

Fly to

San Diego

Route

Depart

Return

Price

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Mon 10/13

6:00 am-8:08 pm

1 stop17h 08m

San Diego

Sat 10/18

2:24 pm-6:19 am

1 stop12h 55m

$233

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 11/4

8:49 am-11:27 am

Nonstop5h 38m

San Diego

Tue 11/11

4:25 pm-5:01 am

1 stop9h 36m

$240

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 10/23

4:56 pm-9:45 pm

1 stop7h 49m

San Diego

Mon 10/27

8:40 pm-10:53 am

2 stops11h 13m

$252

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 10/8

2:33 pm-8:34 pm

1 stop9h 01m

San Diego

Mon 10/13

6:25 am-5:53 pm

1 stop8h 28m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 10/14

6:15 pm-11:14 pm

1 stop7h 59m

San Diego

Mon 10/20

10:20 pm-11:25 am

1 stop10h 05m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 10/2

4:25 pm-11:24 pm

1 stop9h 59m

San Diego

Wed 10/8

7:10 pm-6:21 am

1 stop8h 11m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 11/19

3:40 pm-8:13 pm

1 stop7h 33m

San Diego

Mon 11/24

6:15 am-5:20 pm

1 stop8h 05m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 10/7

2:17 pm-9:20 pm

1 stop10h 03m

San Diego

Tue 10/14

7:10 pm-6:21 am

1 stop8h 11m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sun 10/12

3:51 pm-8:25 pm

1 stop7h 34m

San Diego

Wed 10/15

8:39 pm-11:00 am

2 stops11h 21m

$282

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 9/16

6:59 pm-7:29 am

2 stops39h 30m

San Diego

Sun 10/26

6:41 am-6:19 am

1 stop20h 38m

$292

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 21 results
1
2
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Best time to book a flight from Key Largo to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to San Diego

How far ahead should I book a flight from Key Largo to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to San Diego. Price data was last updated on August 29, 2025.

To ensure you get the cheapest price possible for a flight from Key Largo to San Diego, you should look to book at least 74 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Key Largo to San Diego?

Currently, August is the cheapest month in which you can book a flight from Key Largo to San Diego (average of $286). Flying from Key Largo to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to SAN?

Find hourly flight availability from Key Largo to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

When flying from Key Largo to San Diego, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Key Largo to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to San Diego. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to San Diego flight should consider departing on Tuesday at noon when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to San Diego

Explore weekly flight availability from Key Largo to San Diego. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 11, 2025.

The most flights from KE9 to SAN are scheduled on a Monday (5 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (4 on average).

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated September 11, 2025.
Read through reviews of airlines operating flights from Key Largo to San Diego, such as Alaska Airlines, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.0

Food

7.1

Overall

8.0

Comfort

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.0

Food

7.1

Overall

8.0

Comfort

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Delta
8.0
Very good
7,960 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.0

Food

7.1

Overall

8.0

Comfort

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
United Airlines
7.4
Good
8,937 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.0

Food

7.1

Overall

8.0

Comfort

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.0

Food

7.1

Overall

8.0

Comfort

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Frontier
5.8
Fair
3,177 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.0

Food

7.1

Overall

8.0

Comfort

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Key Largo?

    If you book a flight to San Diego from Key Largo, you will be flying to San Diego, which is the city’s only airport. San Diego (SAN) is located 2.6 mi from the center of San Diego. There are 4 flights from Key Largo to San Diego per day from 9 different airlines.

  • How popular is this Key Largo to San Diego flight route?

    The Key Largo to San Diego flight path was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Key Largo to San Diego?

    A quick flight from Key Largo to San Diego can take about 5h 38m. Frontier provides one of the quickest options available for as low as $240. The distance between Key Largo and San Diego is about 2262 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most reliable airlines from Key Largo to San Diego?

    Before booking your flight to San Diego from Key Largo, check out the most reliable airlines to get you to your destination on time: GOL (76%), American Airlines (75%), Qatar Airways( 75%).

  • What are the cheapest flights from Key Largo to San Diego?

    Looking for the cheapest flight from Key Largo to San Diego? While on average our users pay $617, our data indicates the cheapest price to be $118. The most popular route (Miami - San Diego), is priced around $146.

  • Can I find deals for flights from Key Largo to San Diego that include hotel bookings?

    Yes. In addition to deals on Key Largo to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to San Diego.

  • Can I find deals for business class flights from Key Largo to San Diego?

    Yes. Cheapflights offers flight deals from Key Largo to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Key Largo to San Diego (average of $286). Flying from Key Largo to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
La Mesa
Poway
Lemon Grove
Coronado
Imperial Beach
National City
Alpine

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Top 9 airlines flying from Key Largo to San Diego

Discover the top 9 airlines that operate flights from Key Largo to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$124Average$236FlexibilityNo cancel feeOn-time65%
FrontierCheapest$148Average$211FlexibilityNo cancel feeOn-time62%
JetBlueCheapest$178Average$363FlexibilityNo cancel feeOn-time62%
Alaska AirlinesCheapest$195Average$457FlexibilityNo cancel feeOn-time75%
American AirlinesCheapest$216Average$411FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$236Average$384FlexibilityNo cancel feeOn-time69%
Hawaiian AirlinesCheapest$237Average$382FlexibilityNo cancel feeOn-time85%
DeltaCheapest$246Average$340FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$261Average$421FlexibilityNo cancel feeOn-time63%

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