HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Diego

$127+ Cheap flights from Key Largo, FL to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/20. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — SAN
May 4 — May 111
Sun 5/4
Sun 5/11
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Key Largo to San Diego with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Key Largo to San Diego are usually found in April or August, booked 51 days in advance, depart on a Wednesday or Thursday and return on a Tuesday

Cheap flight deals from Key Largo to San Diego

Keep the following information in mind while searching for Key Largo to San Diego flight deals. Data was last updated April 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$255
(Mytrip)

One-way from

$127
(CheapOair)

Popular in

March

Cheapest in

April

Average price

$354
Provider with most accurate pricing for Miami-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Miami-San Diego flights.
Search Deals
From Key Largo to San Diego
Search Deals
One-way flight from Key Largo to San Diego
Search Deals
High demand for flights, 0% potential price rise
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2025
Search Deals

Find flight deals from Key Largo to San Diego

Cheapest flights from Key Largo to San Diego
Explore the most affordable flight options available from Key Largo to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2025.

This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/88:55 pmMIA - SAN
1 stop13h 18mSpirit Airlines
Mon 5/128:08 amSAN - MIA
2 stops42h 35mSpirit Airlines
Deal found 4/29$255
This Cheapflightsfares deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/237:10 amMIA - SAN
1 stop7h 46mFrontier
Sun 5/257:16 pmSAN - MIA
1 stop7h 24mFrontier
Deal found 4/28$256
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/237:25 amMIA - SAN
1 stop8h 31mDelta
Mon 5/266:15 amSAN - MIA
1 stop8h 52mDelta
Deal found 4/28$257
This CheapOair deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/86:00 amMIA - SAN
1 stop20h 55mMultiple Airlines
Fri 6/137:31 pmSAN - MIA
1 stop7h 24mMultiple Airlines
Deal found 4/29$286
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/308:15 pmMIA - SAN
Nonstop5h 22mAmerican Airlines
Mon 6/910:13 pmSAN - MIA
Nonstop5h 05mAmerican Airlines
Deal found 4/29$292
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/297:55 amMIA - SAN
1 stop9h 15mSouthwest
Tue 5/67:30 amSAN - MIA
1 stop6h 55mSouthwest
Deal found 4/28$317
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/176:00 amMIA - SAN
1 stop10h 02mUnited Airlines
Sun 6/226:28 pmSAN - MIA
1 stop8h 17mUnited Airlines
Deal found 4/28$337
This Alaska Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/206:21 pmMIA - SAN
2 stops18h 11mAlaska Airlines
Sat 5/245:18 pmSAN - MIA
2 stops21h 03mAlaska Airlines
Deal found 4/29$349

Cheapflights Fare Finder

Customize your flight search to find flights from Key Largo to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
Use the filters below to find and compare flights from Key Largo to San Diego that are best for you.

Fly from

Key Largo

Fly to

San Diego

Route

Depart

Return

Price

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 5/8

8:55 pm-7:13 am

1 stop13h 18m

San Diego

Mon 5/12

8:08 am-5:43 am

2 stops42h 35m

$255

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 5/23

7:10 am-11:56 am

1 stop7h 46m

San Diego

Sun 5/25

7:16 pm-5:40 am

1 stop7h 24m

$256

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 5/23

7:25 am-12:56 pm

1 stop8h 31m

San Diego

Tue 5/27

5:02 pm-6:25 am

1 stop10h 23m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sun 6/8

6:00 am-11:55 pm

1 stop20h 55m

San Diego

Fri 6/13

7:31 pm-5:55 am

1 stop7h 24m

$286

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 5/30

8:15 pm-10:37 pm

Nonstop5h 22m

San Diego

Mon 6/9

10:13 pm-6:18 am

Nonstop5h 05m

$292

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 5/20

6:21 pm-9:32 am

2 stops18h 11m

San Diego

Sat 5/24

5:18 pm-5:21 pm

2 stops21h 03m

$349

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sat 5/31

5:05 am-10:25 am

1 stop8h 20m

San Diego

Wed 6/4

8:45 am-9:30 pm

2 stops9h 45m

$357

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 6/3

6:00 am-1:02 pm

1 stop10h 02m

San Diego

Wed 6/4

1:30 pm-5:45 am

2 stops13h 15m

$358

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 5/20

6:00 am-11:11 pm

1 stop20h 11m

$127

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 5/28

3:15 pm-4:45 pm

3 stops28h 30m

$129

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Showing 1-10 of 16 results
1
2

Best time to book a flight from Key Largo to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to San Diego

How far ahead should I book a flight from Key Largo to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to San Diego. Price data was last updated on April 25, 2025.

To ensure you get the cheapest price possible for a flight from Key Largo to San Diego, you should look to book at least 51 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Key Largo to San Diego?

Currently, August is the cheapest month in which you can book a flight from Key Largo to San Diego (average of $286). Flying from Key Largo to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to SAN?

Find hourly flight availability from Key Largo to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 29, 2025.

When flying from Key Largo to San Diego, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Key Largo to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to San Diego. Price data was last updated on May 12, 2024.

Travelers seeking maximum savings on their Key Largo to San Diego flight should consider departing on Tuesday at noon when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to San Diego

Explore weekly flight availability from Key Largo to San Diego. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated April 29, 2025.

The most flights from KE9 to SAN are scheduled on a Saturday (10 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (5 on average).

Rainfall in San Diego by month

Plan your trip to San Diego by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in San Diego ranges from 0.0 - 2.3 inches per month. February is typically the wettest month, when rainfall can reach 2.3 in. July is typically the driest time to visit San Diego when rainfall is around 0.0 in.

Temperature in San Diego by month

Plan your trip to San Diego by taking into account the average temperature totals by month.

If weather is an important factor for your trip to San Diego, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 57.2 F).

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated April 29, 2025.
Read reviews from past customers who have flown Alaska Airlines, Southwest and Delta from Key Largo to San Diego. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,961 reviews

Crew

8.5

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
9,961 reviews
Alaska Airlines
8.0
Very good
9,961 reviews

Crew

8.5

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Southwest
8.0
Very good
4,295 reviews
Alaska Airlines
8.0
Very good
9,961 reviews

Crew

8.5

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,936 reviews
Alaska Airlines
8.0
Very good
9,961 reviews

Crew

8.5

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,696 reviews
Alaska Airlines
8.0
Very good
9,961 reviews

Crew

8.5

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
9,961 reviews

Crew

8.5

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Key Largo?

    If you book a flight to San Diego from Key Largo, you will be flying to San Diego, which is the city’s only airport. San Diego (SAN) is located 2.6 mi from the center of San Diego. There are 7 flights from Key Largo to San Diego per day from 9 different airlines.

  • How popular is this Key Largo to San Diego flight route?

    The Key Largo to San Diego flight path was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Key Largo to San Diego one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $127. However, be on the lookout for offers from Spirit Airlines and Alaska Airlines, as they are both options that can get you from Key Largo to San Diego for a low price.

  • What are the most reliable airlines from Key Largo to San Diego?

    Before booking your flight to San Diego from Key Largo, check out the most reliable airlines to get you to your destination on time: GOL (88%), Alaska Airlines (79%), Qatar Airways( 71%).

  • What are the cheapest flights from Key Largo to San Diego?

    Looking for the cheapest flight from Key Largo to San Diego? While on average our users pay $556, our data indicates the cheapest price to be $118. The most popular route (Miami - San Diego), is priced around $149.

  • Can I find deals for flights from Key Largo to San Diego that include hotel bookings?

    Yes. In addition to deals on Key Largo to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to San Diego.

  • Can I find deals for business class flights from Key Largo to San Diego?

    Yes. Cheapflights offers flight deals from Key Largo to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Key Largo to San Diego (average of $286). Flying from Key Largo to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Key Largo?

Book flights to Key Largo if you plan to visit one of these locations
El Cajon
Chula Vista
Lemon Grove
National City
Imperial Beach
La Mesa
Alpine
Poway
Santee
Coronado

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Key Largo to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
Orlando to Los Angeles flights
Fort Lauderdale to Las Vegas flights
Orlando to Las Vegas flights
Tampa to Las Vegas flights
Miami to Los Angeles flights
Fort Lauderdale to Los Angeles flights
Miami to Las Vegas flights
Orlando to San Francisco flights
Tampa to Los Angeles flights
Miami to San Francisco flights
Orlando to San Diego flights
Tampa to San Francisco flights
Tampa to San Diego flights
Fort Lauderdale to San Francisco flights
West Palm Beach to Las Vegas flights
Orlando to Ontario flights
Orlando to Burbank flights
Miami to Ontario flights
Jacksonville to Las Vegas flights
Orlando to Santa Ana flights
Fort Myers to Las Vegas flights
Fort Lauderdale to Burbank flights
Fort Lauderdale to Santa Ana flights
Fort Lauderdale to San Diego flights
Miami to San Diego flights
Pensacola to Las Vegas flights
Miami to Santa Ana flights
West Palm Beach to Los Angeles flights
Jacksonville to Los Angeles flights
Fort Lauderdale to Ontario flights
Jacksonville to San Francisco flights
Tampa to Ontario flights
Fort Myers to Los Angeles flights
Orlando to San Jose flights
Fort Lauderdale to Oakland flights
Orlando to Oakland flights
Orlando to Sacramento flights
Pensacola to Los Angeles flights
Sarasota to Las Vegas flights
West Palm Beach to San Francisco flights
Miami to San Jose flights
Miami to Burbank flights
Orlando to Reno flights
West Palm Beach to Santa Ana flights
Fort Lauderdale to San Jose flights
Jacksonville to Ontario flights
Jacksonville to San Diego flights
Tampa to Burbank flights
Fort Lauderdale to Reno flights
Tampa to Santa Ana flights

Top 9 airlines flying from Key Largo to San Diego

Discover the top 9 airlines that operate flights from Key Largo to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$117Average$230FlexibilityNo cancel feeOn-time65%
FrontierCheapest$138Average$198FlexibilityNo cancel feeOn-time62%
JetBlueCheapest$178Average$313FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$195Average$385FlexibilityNo cancel feeOn-time71%
Alaska AirlinesCheapest$196Average$462FlexibilityNo cancel feeOn-time75%
DeltaCheapest$204Average$331FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$226Average$374FlexibilityNo cancel feeOn-time69%
Hawaiian AirlinesCheapest$237Average$398FlexibilityNo cancel feeOn-time85%
SouthwestCheapest$266Average$422FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.