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$132+ Cheap flights from Key Largo, FL to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/21. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — SAN
dic. 6 — dic. 131
sáb. 12/6
sáb. 12/13
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to San Diego are usually found in April or May, booked 77 days in advance, depart on a Wednesday or Tuesday and return on a Friday

Cheap flight deals from Key Largo to San Diego

Keep the following information in mind while searching for Key Largo to San Diego flight deals. Data was last updated noviembre 6, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$213
(Kiwi.com)

One-way from

$132
(Kiwi.com)

Popular in

June

Cheapest in

April

Average price

$410
Provider with most accurate pricing for Miami-San Diego flight deals.
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Provider most trusted by Cheapflights users for Miami-San Diego flights.
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From Key Largo to San Diego
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One-way flight from Key Largo to San Diego
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Highest demand for flights based on searches. 2% potential increase in price ($12 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Key Largo to San Diego

Cheapest flights from Key Largo to San Diego
Explore the most affordable flight options available from Key Largo to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on noviembre 6, 2025.

This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/38:22 pmMIA - SAN
Nonstop5h 38mAmerican Airlines
mar. 1/61:27 pmSAN - MIA
Nonstop4h 59mAmerican Airlines
Deal found 11/5$217
This Expedia deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/236:15 amMIA - SAN
1 stop28h 46mFrontier
lun. 12/156:25 amSAN - MIA
1 stop13h 53mFrontier
Deal found 11/5$221
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/87:05 amMIA - SAN
2 stops15h 10mFrontier
vie. 12/126:34 amSAN - MIA
1 stop19h 45mFrontier
Deal found 11/6$223
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/226:55 amMIA - SAN
1 stop20h 04mMultiple Airlines
lun. 11/248:39 amSAN - MIA
2 stops28h 18mMultiple Airlines
Deal found 11/6$228
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/216:55 amMIA - SAN
1 stop20h 04mFrontier
lun. 11/248:46 amSAN - MIA
2 stops41h 24mFrontier
Deal found 11/6$229
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/311:49 amMIA - SAN
2 stops13h 57mMultiple Airlines
dom. 1/46:25 amSAN - MIA
1 stop23h 50mMultiple Airlines
Deal found 11/5$230
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/126:00 amMIA - SAN
1 stop16h 15mFrontier
lun. 12/158:10 pmSAN - MIA
2 stops30h 09mFrontier
Deal found 11/5$231
This Frontier deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/136:00 amMIA - SAN
1 stop12h 52mFrontier
dom. 12/146:25 amSAN - MIA
1 stop13h 34mFrontier
Deal found 11/5$232
This Frontier deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/197:05 amMIA - SAN
1 stop8h 33mFrontier
sáb. 1/107:15 amSAN - MIA
1 stop14h 17mFrontier
Deal found 11/6$236
This Trip.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/257:05 amMIA - SAN
1 stop8h 06mFrontier
mié. 12/311:06 pmSAN - MIA
1 stop13h 29mFrontier
Deal found 11/5$237
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/46:25 amMIA - SAN
1 stop20h 34mFrontier
mié. 12/106:34 amSAN - MIA
2 stops39h 12mFrontier
Deal found 11/6$238

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 6, 2025.
Use the filters below to find and compare flights from Key Largo to San Diego that are best for you.

Fly from

Key Largo

Fly to

San Diego

Route

Depart

Return

Price

MiamiSan Diego

MIA - SAN

MIASAN

Miami

vie. 2/6

9:30 am-12:27 pm

Nonstop5h 57m

San Diego

dom. 2/8

1:27 pm-9:26 pm

Nonstop4h 59m

$217

MiamiSan Diego

MIA - SAN

MIASAN

Miami

mar. 3/10

12:00 pm-6:53 pm

1 stop9h 53m

San Diego

mié. 3/11

9:40 pm-10:40 am

1 stop10h 00m

$277

MiamiSan Diego

MIA - SAN

MIASAN

Miami

mié. 12/3

3:50 pm-9:18 pm

1 stop8h 28m

San Diego

mar. 1/6

6:30 am-6:01 pm

1 stop8h 31m

$277

MiamiSan Diego

MIA - SAN

MIASAN

Miami

jue. 1/8

9:15 am-3:57 pm

1 stop9h 42m

San Diego

dom. 1/11

10:25 pm-6:07 am

Nonstop4h 42m

$297

MiamiSan Diego

MIA - SAN

MIASAN

Miami

jue. 1/8

12:00 pm-7:41 pm

1 stop10h 41m

San Diego

dom. 1/11

1:45 pm-5:30 am

2 stops12h 45m

$307

MiamiSan Diego

MIA - SAN

MIASAN

Miami

sáb. 1/31

6:43 am-4:30 pm

2 stops12h 47m

San Diego

dom. 2/1

1:45 pm-5:28 am

2 stops12h 43m

$318

MiamiSan Diego

MIA - SAN

MIASAN

Miami

dom. 11/16

6:00 am-11:17 am

1 stop8h 17m

San Diego

lun. 12/8

4:57 pm-5:19 am

1 stop9h 22m

$332

MiamiSan Diego

MIA - SAN

MIASAN

Miami

dom. 1/18

7:15 pm-7:13 pm

2 stops26h 58m

San Diego

vie. 1/23

7:55 pm-6:38 am

1 stop7h 43m

$335

MiamiSan Diego

MIA - SAN

MIASAN

Miami

mié. 2/18

1:00 pm-6:33 pm

1 stop8h 33m

San Diego

dom. 2/22

10:30 pm-11:05 am

1 stop9h 35m

$337

MiamiSan Diego

MIA - SAN

MIASAN

Miami

lun. 1/26

7:07 pm-10:46 pm

3 stops30h 39m

$134

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/6

Showing 1-10 of 18 results
1
2

Best time to book a flight from Key Largo to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to San Diego

How far ahead should I book a flight from Key Largo to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to San Diego. Price data was last updated on October 31, 2025.

To ensure you get the cheapest price possible for a flight from Key Largo to San Diego, you should look to book at least 77 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Key Largo to San Diego?

Currently, November is the cheapest month in which you can book a flight from Key Largo to San Diego (average of $103). Flying from Key Largo to San Diego in April is currently the most expensive (average of $223). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to SAN?

Find hourly flight availability from Key Largo to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated noviembre 6, 2025.

It’s typically best to fly out from Key Largo to San Diego at noon. Doing so could potentially save you 21% on the flight price compared to flying in the morning, which is usually more expensive.

What is the cheapest day to fly from Key Largo to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to San Diego. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to San Diego flight should consider departing on Sunday at noon when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to San Diego

Explore weekly flight availability from Key Largo to San Diego. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated noviembre 6, 2025.

The most flights from KE9 to SAN are scheduled on a Monday (8 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (7 on average).

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated noviembre 6, 2025.
Read through reviews of airlines operating flights from Key Largo to San Diego, such as Alaska Airlines, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
11,247 reviews

Entertainment

7.0

Comfort

7.8

Boarding

8.1

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Alaska Airlines
8.0
Very good
11,247 reviews
Alaska Airlines
8.0
Very good
11,247 reviews

Entertainment

7.0

Comfort

7.8

Boarding

8.1

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Delta
7.9
Good
8,001 reviews
Alaska Airlines
8.0
Very good
11,247 reviews

Entertainment

7.0

Comfort

7.8

Boarding

8.1

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
United Airlines
7.4
Good
9,007 reviews
Alaska Airlines
8.0
Very good
11,247 reviews

Entertainment

7.0

Comfort

7.8

Boarding

8.1

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
American Airlines
7.2
Good
11,040 reviews
Alaska Airlines
8.0
Very good
11,247 reviews

Entertainment

7.0

Comfort

7.8

Boarding

8.1

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Frontier
5.8
Fair
3,115 reviews
Alaska Airlines
8.0
Very good
11,247 reviews

Entertainment

7.0

Comfort

7.8

Boarding

8.1

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Key Largo?

    If you book a flight to San Diego from Key Largo, you will be flying to San Diego, which is the city’s only airport. San Diego (SAN) is located 2.6 mi from the center of San Diego. There are 7 flights from Key Largo to San Diego per day from 9 different airlines.

  • How popular is this Key Largo to San Diego flight route?

    The Key Largo to San Diego flight path was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Key Largo to San Diego?

    A quick flight from Key Largo to San Diego can take about 5h 57m. American Airlines provides one of the quickest options available for as low as $217. The distance between Key Largo and San Diego is about 2262 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most reliable airlines from Key Largo to San Diego?

    Before booking your flight to San Diego from Key Largo, check out the most reliable airlines to get you to your destination on time: GOL (73%), American Airlines (66%), Alaska Airlines( 51%).

  • What are the cheapest flights from Key Largo to San Diego?

    Looking for the cheapest flight from Key Largo to San Diego? While on average our users pay $893, our data indicates the cheapest price to be $118. The most popular route (Miami - San Diego), is priced around $154.

  • Can I find deals for flights from Key Largo to San Diego that include hotel bookings?

    Yes. In addition to deals on Key Largo to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to San Diego.

  • Can I find deals for business class flights from Key Largo to San Diego?

    Yes. Cheapflights offers flight deals from Key Largo to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to San Diego?

    Currently, November is the cheapest month in which you can book a flight from Key Largo to San Diego (average of $103). Flying from Key Largo to San Diego in April is currently the most expensive (average of $223). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
La Mesa
Poway
Lemon Grove
National City

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Top 9 airlines flying from Key Largo to San Diego

Discover the top 9 airlines that operate flights from Key Largo to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$108Average$222FlexibilityNo cancel feeOn-time65%
FrontierCheapest$145Average$213FlexibilityNo cancel feeOn-time62%
SouthwestCheapest$166Average$410FlexibilityNo cancel feeOn-time63%
JetBlueCheapest$178Average$371FlexibilityNo cancel feeOn-time62%
Alaska AirlinesCheapest$188Average$452FlexibilityNo cancel feeOn-time75%
Hawaiian AirlinesCheapest$199Average$357FlexibilityNo cancel feeOn-time85%
United AirlinesCheapest$229Average$375FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$236Average$388FlexibilityNo cancel feeOn-time71%
DeltaCheapest$246Average$346FlexibilityNo cancel feeOn-timeN/A

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