$138+ Cheap flights from Key Largo, FL to San Diego (SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/31. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — SAN
Mar 6 — Mar 131
1 adult, Economy
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Find cheap flights from Key Largo to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Key Largo to San Diego are usually found in April or May, booked 19 days in advance, depart on a Wednesday or Thursday and return on a Saturday
Cheap flight deals from Key Largo to San Diego
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Last-minute
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Cheapest flights from Key Largo to San DiegoExplore the most affordable flight options available from Key Largo to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.
Explore the most affordable flight options available from Key Largo to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/176:25 am
MIA
- SAN
1 stop18h 16m
Frontier
Tue 2/247:11 am
SAN
- MIA
1 stop19h 37m
Frontier
Deal found 2/1![Frontier logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2011:35 am
MIA
- SAN
2 stops15h 33m
Frontier
Tue 2/247:11 am
SAN
- MIA
1 stop19h 37m
Frontier
Deal found 2/1![Frontier logo]()
$256
This Mytrip deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:25 am
MIA
- SAN
1 stop20h 43m
Frontier
Sat 2/216:25 am
SAN
- MIA
1 stop19h 49m
Frontier
Deal found 2/1![Frontier logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:25 am
MIA
- SAN
1 stop18h 16m
Frontier
Sat 2/2812:23 pm
SAN
- MIA
2 stops19h 00m
Frontier
Deal found 2/1![Frontier logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/156:45 am
MIA
- SAN
1 stop20h 23m
Frontier
Sat 2/286:25 am
SAN
- MIA
2 stops12h 34m
Frontier
Deal found 2/1![Frontier logo]()
$261
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:25 am
MIA
- SAN
1 stop20h 43m
Frontier
Mon 2/236:25 am
SAN
- MIA
1 stop20h 23m
Frontier
Deal found 2/2![Frontier logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/269:10 pm
MIA
- SAN
1 stop14h 40m
Frontier
Sun 3/16:25 am
SAN
- MIA
2 stops15h 17m
Frontier
Deal found 2/2![Frontier logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/1510:05 am
MIA
- SAN
2 stops17h 03m
Multiple Airlines
Sun 2/229:09 am
SAN
- MIA
1 stop17h 05m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/275:15 am
MIA
- SAN
2 stops18h 18m
Frontier
Sun 4/56:25 am
SAN
- MIA
1 stop20h 24m
Frontier
Deal found 2/3![Frontier logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/249:18 pm
MIA
- SAN
1 stop23h 33m
Multiple Airlines
Tue 3/37:11 am
SAN
- MIA
1 stop19h 03m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/96:45 am
MIA
- SAN
2 stops41h 56m
Multiple Airlines
Sat 2/1411:21 am
SAN
- MIA
1 stop20h 02m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$276
This eDestinos deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2710:17 pm
MIA
- SAN
1 stop15h 09m
Frontier
Mon 3/211:30 am
SAN
- MIA
1 stop14h 44m
Frontier
Deal found 2/2![Frontier logo]()
$278
Best flights from Key Largo to San DiegoDiscover carefully curated flight deals from Key Largo to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 4, 2026.
Discover carefully curated flight deals from Key Largo to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 4, 2026.
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/153:30 pm
MIA
- SAN
1 stop8h 52m
United Airlines
Wed 4/298:45 am
SAN
- MIA
1 stop8h 09m
United Airlines
Deal found 2/2![United Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/159:19 am
MIA
- SAN
Nonstop5h 34m
American Airlines
Sun 4/1910:05 pm
SAN
- MIA
Nonstop4h 55m
American Airlines
Deal found 2/3![American Airlines logo]()
$372
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/288:05 am
MIA
- SAN
1 stop9h 49m
Delta
Sat 4/42:18 pm
SAN
- MIA
1 stop7h 34m
Delta
Deal found 2/2![Delta logo]()
$379
This Frontier deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/82:18 pm
MIA
- SAN
1 stop12h 50m
Frontier
Thu 2/1211:59 am
SAN
- MIA
1 stop14h 15m
Frontier
Deal found 2/3![Frontier logo]()
$395
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/135:10 am
MIA
- SAN
1 stop7h 35m
Southwest
Sat 3/216:45 am
SAN
- MIA
1 stop13h 15m
Southwest
Deal found 2/1![Southwest logo]()
$399
This Expedia deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/235:45 pm
MIA
- SAN
1 stop9h 26m
Multiple Airlines
Sun 4/2610:05 pm
SAN
- MIA
Nonstop4h 55m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$410
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/126:40 am
MIA
- SAN
1 stop8h 55m
Southwest
Sat 3/216:45 am
SAN
- MIA
1 stop13h 15m
Southwest
Deal found 2/1![Southwest logo]()
$399
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:40 pm
MIA
- SAN
Nonstop6h 00m
American Airlines
Sun 3/81:01 pm
SAN
- MIA
Nonstop5h 01m
American Airlines
Deal found 2/3![American Airlines logo]()
$405
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/63:15 pm
MIA
- SAN
2 stops11h 05m
Southwest
Wed 3/116:20 am
SAN
- MIA
2 stops12h 55m
Southwest
Deal found 2/3![Southwest logo]()
$402
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/103:35 pm
MIA
- SAN
2 stops9h 55m
Southwest
Tue 3/176:50 am
SAN
- MIA
2 stops11h 55m
Southwest
Deal found 2/1![Southwest logo]()
$402
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1512:10 pm
MIA
- SAN
2 stops10h 25m
Southwest
Sun 4/1910:40 pm
SAN
- MIA
2 stops11h 30m
Southwest
Deal found 2/3![Southwest logo]()
$402
Last-minute flights from Key Largo to San DiegoDiscover last-minute flight deals from Key Largo to San Diego. Data last updated February 4, 2026 and is based on user searches.
Discover last-minute flight deals from Key Largo to San Diego. Data last updated February 4, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/96:45 am
MIA
- SAN
2 stops41h 56m
Multiple Airlines
Sat 2/1411:21 am
SAN
- MIA
1 stop20h 02m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/156:45 am
MIA
- SAN
1 stop20h 23m
Frontier
Sat 2/286:25 am
SAN
- MIA
2 stops12h 34m
Frontier
Deal found 2/1![Frontier logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/1510:05 am
MIA
- SAN
2 stops17h 03m
Multiple Airlines
Sun 2/229:09 am
SAN
- MIA
1 stop17h 05m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/176:25 am
MIA
- SAN
1 stop18h 16m
Frontier
Tue 2/247:11 am
SAN
- MIA
1 stop19h 37m
Frontier
Deal found 2/1![Frontier logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:25 am
MIA
- SAN
1 stop18h 16m
Frontier
Sat 2/2812:23 pm
SAN
- MIA
2 stops19h 00m
Frontier
Deal found 2/1![Frontier logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2011:35 am
MIA
- SAN
2 stops15h 33m
Frontier
Tue 2/247:11 am
SAN
- MIA
1 stop19h 37m
Frontier
Deal found 2/1![Frontier logo]()
$256
This Mytrip deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:25 am
MIA
- SAN
1 stop20h 43m
Frontier
Sat 2/216:25 am
SAN
- MIA
1 stop19h 49m
Frontier
Deal found 2/1![Frontier logo]()
$257
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:25 am
MIA
- SAN
1 stop20h 43m
Frontier
Mon 2/236:25 am
SAN
- MIA
1 stop20h 23m
Frontier
Deal found 2/2![Frontier logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/249:18 pm
MIA
- SAN
1 stop23h 33m
Multiple Airlines
Tue 3/37:11 am
SAN
- MIA
1 stop19h 03m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/269:10 pm
MIA
- SAN
1 stop14h 40m
Frontier
Sun 3/16:25 am
SAN
- MIA
2 stops15h 17m
Frontier
Deal found 2/2![Frontier logo]()
$268
This eDestinos deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2710:17 pm
MIA
- SAN
1 stop15h 09m
Frontier
Mon 3/211:30 am
SAN
- MIA
1 stop14h 44m
Frontier
Deal found 2/2![Frontier logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/275:15 am
MIA
- SAN
2 stops18h 18m
Frontier
Sun 4/56:25 am
SAN
- MIA
1 stop20h 24m
Frontier
Deal found 2/3![Frontier logo]()
$274
One-way flights from Key Largo to San DiegoSearch for one-way flight options from Key Largo to San Diego. Find affordable one-way fares based on user searches. Data last updated February 4, 2026.
Search for one-way flight options from Key Largo to San Diego. Find affordable one-way fares based on user searches. Data last updated February 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/318:35 pm
MIA
- SAN
2 stops20h 29m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/224:01 pm
MIA
- SAN
1 stop19h 54m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$139
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2710:17 pm
MIA
- SAN
1 stop15h 09m
Frontier
Deal found 2/2![Frontier logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/183:16 pm
MIA
- SAN
2 stops29h 22m
Frontier
Deal found 2/2![Frontier logo]()
$143
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:25 am
MIA
- SAN
1 stop20h 43m
Frontier
Deal found 2/4![Frontier logo]()
$146
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/197:04 pm
MIA
- SAN
2 stops32h 12m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$147
This Super.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/156:45 am
MIA
- SAN
1 stop27h 55m
Frontier
Deal found 2/3![Frontier logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:05 am
MIA
- SAN
2 stops15h 30m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/35:05 am
MIA
- SAN
2 stops22h 06m
Frontier
Deal found 2/3![Frontier logo]()
$153
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/239:18 pm
MIA
- SAN
3 stops26h 06m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$156
Find flight deals from Key Largo to San Diego
Keep the following information in mind while searching for Key Largo to San Diego flight deals. Data was last updated February 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $253 (Kiwi.com) |
One-way from | $138 (Kiwi.com) |
Popular in | December |
Cheapest in | April |
Average price | $415 |
Cheapflights Fare Finder
Customize your flight search to find flights from Key Largo to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Key Largo to San Diego that are best for you.
Fly from
Key Largo
Fly to
San Diego
Route
Depart
Return
Price
MiamiSan Diego
MIA - SAN
MIASAN
Miami
Wed 4/15
3:30 pm-9:22 pm
1 stop8h 52m
San Diego
Wed 4/29
8:45 am-7:54 pm
1 stop8h 09m
$359
MiamiSan Diego
MIA - SAN
MIASAN
Miami
Wed 4/15
9:19 am-11:53 am
Nonstop5h 34m
San Diego
Sun 4/19
10:05 pm-6:00 am
Nonstop4h 55m
$372
MiamiSan Diego
MIA - SAN
MIASAN
Miami
Sat 3/28
8:05 am-2:54 pm
1 stop9h 49m
San Diego
Sat 4/4
2:18 pm-12:52 am
1 stop7h 34m
$379
MiamiSan Diego
MIA - SAN
MIASAN
Miami
Sun 2/8
2:18 pm-12:08 am
1 stop12h 50m
San Diego
Thu 2/12
11:59 am-5:14 am
1 stop14h 15m
$395
MiamiSan Diego
MIA - SAN
MIASAN
Miami
Fri 3/13
5:10 am-9:45 am
1 stop7h 35m
San Diego
Sat 3/21
6:45 am-11:00 pm
1 stop13h 15m
$399
MiamiSan Diego
MIA - SAN
MIASAN
Miami
Thu 3/12
6:40 am-12:35 pm
1 stop8h 55m
San Diego
Sat 3/21
6:45 am-11:00 pm
1 stop13h 15m
$399
MiamiSan Diego
MIA - SAN
MIASAN
Miami
Fri 3/6
3:15 pm-11:20 pm
2 stops11h 05m
San Diego
Wed 3/11
6:20 am-10:15 pm
2 stops12h 55m
$402
MiamiSan Diego
MIA - SAN
MIASAN
Miami
Tue 3/10
3:35 pm-10:30 pm
2 stops9h 55m
San Diego
Tue 3/17
6:50 am-9:45 pm
2 stops11h 55m
$402
MiamiSan Diego
MIA - SAN
MIASAN
Miami
Wed 4/15
12:10 pm-7:35 pm
2 stops10h 25m
San Diego
Sun 4/19
10:40 pm-1:10 pm
2 stops11h 30m
$402
MiamiSan Diego
MIA - SAN
MIASAN
Miami
Fri 3/6
7:40 pm-10:40 pm
Nonstop6h 00m
San Diego
Sun 3/8
1:01 pm-9:02 pm
Nonstop5h 01m
$405
Showing 1-10 of 23 results
Best time to book a flight from Key Largo to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Key Largo with our price prediction graph.
MIA-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Key Largo to San Diego
KE9-SAN
MIA-SAN
How far ahead should I book a flight from Key Largo to San Diego?
Use this chart to determine the optimal time to book a round-trip flight from Key Largo to San Diego. Price data was last updated on January 30, 2026.
To ensure you get the cheapest price possible for a flight from Key Largo to San Diego, you should look to book at least 19 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Key Largo to San Diego?
Currently, March is the cheapest month in which you can book a flight from Key Largo to San Diego (average of $122). Flying from Key Largo to San Diego in April is currently the most expensive (average of $212). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from KE9 to SAN?
Find hourly flight availability from Key Largo to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 4, 2026.
When flying from Key Largo to San Diego, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
Weekly flight availability from Key Largo to San Diego
Explore weekly flight availability from Key Largo to San Diego. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated February 4, 2026.
The most flights from KE9 to SAN are scheduled on a Monday (7 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (7 on average).
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated February 4, 2026.
Read through reviews of airlines operating flights from Key Largo to San Diego, such as Alaska Airlines, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Food
7.1
Overall
8.0
Crew
8.5
Entertainment
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Jan 2026
STS - LAX
Comfort
7.8
Food
7.1
Overall
8.0
Crew
8.5
Entertainment
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Jan 2026
STS - LAX
Comfort
7.8
Food
7.1
Overall
8.0
Crew
8.5
Entertainment
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Jan 2026
STS - LAX
Comfort
7.8
Food
7.1
Overall
8.0
Crew
8.5
Entertainment
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Jan 2026
STS - LAX
Comfort
7.8
Food
7.1
Overall
8.0
Crew
8.5
Entertainment
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Jan 2026
STS - LAX
Comfort
7.8
Food
7.1
Overall
8.0
Crew
8.5
Entertainment
7.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,Jan 2026
STS - LAX
Related info for your journey
Find useful and relevant information for your journey from Key Largo to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove
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Alternative routes for Key Largo to San Diego
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Complete your trip
Complete your trip to San Diego by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Key Largo to San Diego by cabin class
Find flights from Key Largo to San Diego, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Key Largo and San Diego flights
Browse other Key Largo and San Diego flight options. Last updated on February 4, 2026.
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Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 4, 2026.
Key Largo to San Diego flights
Consider these flights traveling from Key Largo to San Diego.
Top 8 airlines flying from Key Largo to San Diego
Discover the top 8 airlines that operate flights from Key Largo to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$108 | Average$219 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$155 | Average$239 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$166 | Average$401 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$199 | Average$357 | FlexibilityNo cancel fee | On-time85% | |
| Cheapest$204 | Average$354 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$216 | Average$467 | FlexibilityNo cancel fee | On-time75% | |
| Cheapest$221 | Average$382 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$371 | FlexibilityNo cancel fee | On-time69% |