HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Diego

$109+ Cheap flights from Key Largo, FL to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — SAN
Aug 25 — Sep 11
Mon 8/25
Mon 9/1
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Key Largo to San Diego with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Key Largo to San Diego are usually found in April or May, booked 75 days in advance, depart on a Wednesday or Thursday and return on a Friday

Cheap flight deals from Key Largo to San Diego

Keep the following information in mind while searching for Key Largo to San Diego flight deals. Data was last updated August 20, 2025.

Round-trip from

$204
(Frontier)

One-way from

$109
(Cheapflightsfares)

Popular in

June

Cheapest in

April

Average price

$408
From Key Largo to San Diego
Search Deals
One-way flight from Key Largo to San Diego
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($13 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2025
Search Deals

Find flight deals from Key Largo to San Diego

Cheapest flights from Key Largo to San Diego
Explore the most affordable flight options available from Key Largo to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2025.

This Frontier deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/146:00 amMIA - SAN
1 stop8h 09mFrontier
Fri 9/197:11 pmSAN - MIA
2 stops18h 19mFrontier
Deal found 8/18$204
This Booking.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/36:00 amMIA - SAN
1 stop20h 53mFrontier
Sun 10/1212:46 pmSAN - MIA
1 stop7h 56mFrontier
Deal found 8/19$205
This FlightHub deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/287:23 pmMIA - SAN
1 stop15h 06mMultiple Airlines
Sun 10/55:37 pmSAN - MIA
1 stop22h 20mMultiple Airlines
Deal found 8/19$207
This Frontier deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:05 amMIA - SAN
2 stops14h 35mFrontier
Sun 11/165:47 pmSAN - MIA
1 stop9h 32mFrontier
Deal found 8/18$208
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/249:30 pmMIA - SAN
1 stop12h 56mMultiple Airlines
Sat 11/16:41 amSAN - MIA
1 stop20h 38mMultiple Airlines
Deal found 8/19$209
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/177:20 pmMIA - SAN
1 stop15h 09mMultiple Airlines
Wed 9/241:35 pmSAN - MIA
2 stops25h 29mMultiple Airlines
Deal found 8/20$210
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/237:13 pmMIA - SAN
2 stops17h 44mMultiple Airlines
Sun 10/2612:46 pmSAN - MIA
1 stop7h 56mMultiple Airlines
Deal found 8/19$211
This FlightHub deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/126:00 amMIA - SAN
1 stop8h 09mMultiple Airlines
Tue 9/167:47 pmSAN - MIA
1 stop20h 08mMultiple Airlines
Deal found 8/19$212
This FlightHub deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/77:23 pmMIA - SAN
1 stop15h 06mMultiple Airlines
Sun 9/143:55 pmSAN - MIA
1 stop28h 05mMultiple Airlines
Deal found 8/19$213
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/276:45 amMIA - SAN
1 stop18h 39mMultiple Airlines
Wed 10/17:47 pmSAN - MIA
2 stops25h 57mMultiple Airlines
Deal found 8/18$214
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/196:00 amMIA - SAN
1 stop8h 09mMultiple Airlines
Mon 9/297:47 pmSAN - MIA
2 stops19h 17mMultiple Airlines
Deal found 8/19$215
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/196:00 amMIA - SAN
1 stop8h 09mFrontier
Sun 9/219:03 pmSAN - MIA
2 stops18h 54mFrontier
Deal found 8/19$216

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Key Largo to San Diego that are best for you.

Fly from

Key Largo

Fly to

San Diego

Route

Depart

Return

Price

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 9/25

6:00 am-11:09 am

1 stop8h 09m

San Diego

Thu 10/2

6:25 am-11:27 pm

2 stops14h 02m

$204

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sun 9/14

6:00 am-11:09 am

1 stop8h 09m

San Diego

Fri 9/19

7:11 pm-4:30 pm

2 stops18h 19m

$204

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 11/6

5:05 am-6:09 pm

2 stops16h 04m

San Diego

Sat 11/8

7:18 pm-6:19 am

1 stop8h 01m

$205

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 10/3

6:00 am-11:53 pm

1 stop20h 53m

San Diego

Sun 10/12

12:46 pm-11:42 pm

1 stop7h 56m

$205

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sun 9/28

7:23 pm-7:29 am

1 stop15h 06m

San Diego

Sun 10/5

5:37 pm-6:57 pm

1 stop22h 20m

$207

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 11/14

5:05 am-4:40 pm

2 stops14h 35m

San Diego

Sun 11/16

5:47 pm-6:19 am

1 stop9h 32m

$208

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 11/7

5:05 am-4:40 pm

2 stops14h 35m

San Diego

Sun 11/16

5:47 pm-6:19 am

1 stop9h 32m

$208

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 9/19

8:48 pm-6:42 pm

2 stops24h 54m

San Diego

Sun 9/28

6:35 am-12:44 am

1 stop15h 09m

$210

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 9/17

7:20 pm-7:29 am

1 stop15h 09m

San Diego

Wed 9/24

1:35 pm-6:04 pm

2 stops25h 29m

$210

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 10/23

7:13 pm-9:57 am

2 stops17h 44m

San Diego

Sun 10/26

12:46 pm-11:42 pm

1 stop7h 56m

$211

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/19

Showing 1-10 of 22 results
1
2
3

Best time to book a flight from Key Largo to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to San Diego

How far ahead should I book a flight from Key Largo to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to San Diego. Price data was last updated on August 8, 2025.

To ensure you get the cheapest price possible for a flight from Key Largo to San Diego, you should look to book at least 74 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Key Largo to San Diego?

Currently, August is the cheapest month in which you can book a flight from Key Largo to San Diego (average of $286). Flying from Key Largo to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to SAN?

Find hourly flight availability from Key Largo to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 20, 2025.

When flying from Key Largo to San Diego, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Key Largo to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to San Diego. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to San Diego flight should consider departing on Tuesday at noon when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to San Diego

Explore weekly flight availability from Key Largo to San Diego. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated August 20, 2025.

The most flights from KE9 to SAN are scheduled on a Monday (5 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (4 on average).

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated August 20, 2025.
Read through reviews of airlines operating flights from Key Largo to San Diego, such as Alaska Airlines, Delta, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Food

7.1

Boarding

8.1

Overall

8.0

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
10.0
Excellent

Anonymous,Aug 2025

PDX - SJC

They had no snacks and had to pay for the Wifi.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Food

7.1

Boarding

8.1

Overall

8.0

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
10.0
Excellent

Anonymous,Aug 2025

PDX - SJC

They had no snacks and had to pay for the Wifi.
Delta
8.0
Very good
7,982 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Food

7.1

Boarding

8.1

Overall

8.0

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
10.0
Excellent

Anonymous,Aug 2025

PDX - SJC

They had no snacks and had to pay for the Wifi.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Food

7.1

Boarding

8.1

Overall

8.0

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
10.0
Excellent

Anonymous,Aug 2025

PDX - SJC

They had no snacks and had to pay for the Wifi.
Spirit Airlines
6.3
Okay
8,039 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Food

7.1

Boarding

8.1

Overall

8.0

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
10.0
Excellent

Anonymous,Aug 2025

PDX - SJC

They had no snacks and had to pay for the Wifi.
Frontier
5.8
Fair
3,207 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Food

7.1

Boarding

8.1

Overall

8.0

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
10.0
Excellent

Anonymous,Aug 2025

PDX - SJC

They had no snacks and had to pay for the Wifi.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Key Largo?

    If you book a flight to San Diego from Key Largo, you will be flying to San Diego, which is the city’s only airport. San Diego (SAN) is located 2.6 mi from the center of San Diego. There are 4 flights from Key Largo to San Diego per day from 9 different airlines.

  • How popular is this Key Largo to San Diego flight route?

    The Key Largo to San Diego flight path was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Key Largo to San Diego?

    A quick flight from Key Largo to San Diego can take about 8h 09m. Frontier provides one of the quickest options available for as low as $204. The distance between Key Largo and San Diego is about 2262 mi.

  • What are the most reliable airlines from Key Largo to San Diego?

    Before booking your flight to San Diego from Key Largo, check out the most reliable airlines to get you to your destination on time: American Airlines (73%), Qatar Airways (73%), Alaska Airlines( 73%).

  • What are the cheapest flights from Key Largo to San Diego?

    Looking for the cheapest flight from Key Largo to San Diego? While on average our users pay $369, our data indicates the cheapest price to be $118. The most popular route (Miami - San Diego), is priced around $131.

  • Can I find deals for flights from Key Largo to San Diego that include hotel bookings?

    Yes. In addition to deals on Key Largo to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to San Diego.

  • Can I find deals for business class flights from Key Largo to San Diego?

    Yes. Cheapflights offers flight deals from Key Largo to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Key Largo to San Diego (average of $286). Flying from Key Largo to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
La Mesa
Poway
Lemon Grove
Coronado
Imperial Beach
National City
Alpine

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Key Largo to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
Orlando to Las Vegas flights
Fort Lauderdale to Las Vegas flights
Orlando to Los Angeles flights
Miami to Las Vegas flights
Tampa to Las Vegas flights
Miami to Los Angeles flights
Fort Lauderdale to Los Angeles flights
Jacksonville to Las Vegas flights
Tampa to San Francisco flights
Tampa to Los Angeles flights
Miami to San Francisco flights
Orlando to San Francisco flights
Fort Lauderdale to San Francisco flights
West Palm Beach to Las Vegas flights
Orlando to San Diego flights
Tampa to San Diego flights
Fort Lauderdale to Burbank flights
Miami to San Diego flights
Orlando to Sacramento flights
Miami to Ontario flights
Orlando to Santa Ana flights
Fort Lauderdale to Santa Ana flights
Fort Lauderdale to San Diego flights
Fort Myers to Las Vegas flights
Orlando to Ontario flights
West Palm Beach to Los Angeles flights
Jacksonville to San Francisco flights
Tampa to Ontario flights
Tampa to Santa Ana flights
Orlando to Burbank flights
Fort Lauderdale to Ontario flights
Valparaiso to Las Vegas flights
Tampa to San Jose flights
Tampa to Oakland flights
Orlando to Oakland flights
Miami to Burbank flights
Tampa to Sacramento flights
Orlando to San Jose flights
Pensacola to Las Vegas flights
Sarasota to Las Vegas flights
Miami to Santa Ana flights
Tampa to Burbank flights
Miami to Oakland flights
Panama City to Las Vegas flights
West Palm Beach to San Francisco flights
Miami to San Jose flights
Fort Lauderdale to Sacramento flights
Valdosta to San Francisco flights
Orlando to Reno flights
Fort Lauderdale to San Jose flights

Top 9 airlines flying from Key Largo to San Diego

Discover the top 9 airlines that operate flights from Key Largo to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$124Average$231FlexibilityNo cancel feeOn-time65%
JetBlueCheapest$139Average$336FlexibilityNo cancel feeOn-time62%
FrontierCheapest$148Average$218FlexibilityNo cancel feeOn-time62%
Alaska AirlinesCheapest$196Average$461FlexibilityNo cancel feeOn-time75%
American AirlinesCheapest$206Average$408FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$236Average$387FlexibilityNo cancel feeOn-time69%
Hawaiian AirlinesCheapest$237Average$390FlexibilityNo cancel feeOn-time85%
DeltaCheapest$246Average$344FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$261Average$432FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.