San Diego

$138+ Cheap flights from Key Largo, FL to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/16. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — SAN
Feb 20 — Feb 271
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Cheapflights Tip: The best prices from Key Largo to San Diego are usually found in April or February, booked 19 days in advance, depart on a Wednesday or Thursday and return on a Saturday

Cheap flight deals from Key Largo to San Diego

Cheapest flights from Key Largo to San Diego
Explore the most affordable flight options available from Key Largo to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This Frontier deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/286:18 pm
MIA
-
SAN
1 stop8h 13m
Frontier
Mon 2/26:30 am
SAN
-
MIA
1 stop7h 07m
Frontier
Deal found 1/20$222
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/204:01 pm
MIA
-
SAN
1 stop21h 25m
Multiple Airlines
Fri 2/278:35 am
SAN
-
MIA
1 stop17h 39m
Multiple Airlines
Deal found 1/20$228
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/199:10 pm
MIA
-
SAN
1 stop14h 40m
Multiple Airlines
Wed 2/259:45 am
SAN
-
MIA
1 stop22h 55m
Multiple Airlines
Deal found 1/20$231
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/199:10 pm
MIA
-
SAN
1 stop14h 40m
Multiple Airlines
Fri 2/278:18 pm
SAN
-
MIA
2 stops12h 22m
Multiple Airlines
Deal found 1/20$233
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/176:25 am
MIA
-
SAN
1 stop18h 16m
Frontier
Sat 2/286:25 am
SAN
-
MIA
2 stops24h 58m
Frontier
Deal found 1/20$235
This Expedia deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/62:18 pm
MIA
-
SAN
1 stop12h 50m
Frontier
Mon 2/96:30 am
SAN
-
MIA
1 stop7h 07m
Frontier
Deal found 1/21$236
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/199:10 pm
MIA
-
SAN
1 stop14h 40m
Frontier
Thu 2/266:25 am
SAN
-
MIA
2 stops15h 17m
Frontier
Deal found 1/20$237
This Kiwi.com deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/276:15 pm
MIA
-
SAN
1 stop9h 01m
Frontier
Mon 3/309:58 pm
SAN
-
MIA
2 stops14h 39m
Frontier
Deal found 1/21$239
This Kiwi.com deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/204:01 pm
MIA
-
SAN
1 stop21h 25m
Multiple Airlines
Mon 2/239:50 am
SAN
-
MIA
1 stop22h 50m
Multiple Airlines
Deal found 1/21$240
This Super.com deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/55:47 pm
MIA
-
SAN
1 stop9h 21m
Frontier
Sun 2/86:30 am
SAN
-
MIA
1 stop14h 29m
Frontier
Deal found 1/21$241
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/134:01 pm
MIA
-
SAN
1 stop21h 25m
Multiple Airlines
Tue 2/177:11 am
SAN
-
MIA
2 stops24h 17m
Multiple Airlines
Deal found 1/20$242
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/176:25 am
MIA
-
SAN
1 stop18h 16m
Multiple Airlines
Wed 2/259:45 am
SAN
-
MIA
2 stops23h 31m
Multiple Airlines
Deal found 1/20$243

Find flight deals from Key Largo to San Diego

Keep the following information in mind while searching for Key Largo to San Diego flight deals. Data was last updated January 21, 2026.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$219
(Kiwi.com)

One-way from

$138
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$403
Provider with most accurate pricing for Miami-San Diego flight deals.
Provider most trusted by Cheapflights users for Miami-San Diego flights.
From Key Largo to San Diego
One-way flight from Key Largo to San Diego
Highest demand for flights based on searches. 5% potential increase in price ($24 potential increase over avg. RT price).
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Average for round-trip flights in January 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Key Largo to San Diego that are best for you.

Fly from

Key Largo

Fly to

San Diego

Route

Depart

Return

Price

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 4/29

6:04 pm-9:55 am

1 stop18h 51m

San Diego

Mon 5/4

8:37 pm-5:04 pm

1 stop17h 27m

$247

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 2/20

6:25 am-12:08 am

1 stop20h 43m

San Diego

Sun 2/22

6:25 am-5:14 am

1 stop19h 49m

$279

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sun 2/1

2:18 pm-12:08 am

1 stop12h 50m

San Diego

Wed 2/4

7:00 am-8:59 pm

1 stop10h 59m

$290

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 3/13

5:59 pm-9:49 pm

1 stop30h 50m

San Diego

Mon 3/16

8:26 pm-4:59 pm

1 stop17h 33m

$327

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 4/29

6:42 am-12:08 pm

1 stop8h 26m

San Diego

Tue 5/12

1:35 pm-6:07 am

2 stops13h 32m

$328

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 2/10

12:00 pm-6:50 pm

2 stops9h 50m

San Diego

Wed 2/18

7:25 am-8:05 pm

1 stop9h 40m

$344

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 2/24

12:00 pm-7:10 pm

2 stops10h 10m

San Diego

Tue 3/31

9:20 pm-11:45 am

2 stops11h 25m

$349

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 6/30

8:05 am-2:08 pm

1 stop9h 03m

San Diego

Wed 7/8

2:00 pm-12:54 am

1 stop7h 54m

$359

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 6/30

7:15 am-12:55 pm

1 stop8h 40m

San Diego

Tue 7/7

6:15 am-5:48 pm

1 stop8h 33m

$359

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 4/28

6:42 am-12:08 pm

1 stop8h 26m

San Diego

Sat 5/16

12:50 pm-12:56 am

1 stop9h 06m

$359

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/21

Showing 1-10 of 24 results
1
2
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Best time to book a flight from Key Largo to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to San Diego

How far ahead should I book a flight from Key Largo to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to San Diego. Price data was last updated on January 16, 2026.

To ensure you get the cheapest price possible for a flight from Key Largo to San Diego, you should look to book at least 19 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Key Largo to San Diego?

Currently, March is the cheapest month in which you can book a flight from Key Largo to San Diego (average of $119). Flying from Key Largo to San Diego in April is currently the most expensive (average of $211). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to SAN?

Find hourly flight availability from Key Largo to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 21, 2026.

When flying from Key Largo to San Diego, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Weekly flight availability from Key Largo to San Diego

Explore weekly flight availability from Key Largo to San Diego. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated January 21, 2026.

The most flights from KE9 to SAN are scheduled on a Monday (8 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (7 on average).

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated January 21, 2026.
Read through reviews of airlines operating flights from Key Largo to San Diego, such as Alaska Airlines, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Boarding

8.1

Comfort

7.8

Overall

8.0

Crew

8.5

Entertainment

7.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2026

STS - LAX

Enjoyed staff assistance from ticking thru tsa , boarding and in the plane Couldn’t pick a seat except upgrading

Boarding

8.1

Comfort

7.8

Overall

8.0

Crew

8.5

Entertainment

7.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2026

STS - LAX

Enjoyed staff assistance from ticking thru tsa , boarding and in the plane Couldn’t pick a seat except upgrading

Boarding

8.1

Comfort

7.8

Overall

8.0

Crew

8.5

Entertainment

7.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2026

STS - LAX

Enjoyed staff assistance from ticking thru tsa , boarding and in the plane Couldn’t pick a seat except upgrading

Boarding

8.1

Comfort

7.8

Overall

8.0

Crew

8.5

Entertainment

7.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2026

STS - LAX

Enjoyed staff assistance from ticking thru tsa , boarding and in the plane Couldn’t pick a seat except upgrading

Boarding

8.1

Comfort

7.8

Overall

8.0

Crew

8.5

Entertainment

7.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2026

STS - LAX

Enjoyed staff assistance from ticking thru tsa , boarding and in the plane Couldn’t pick a seat except upgrading

Boarding

8.1

Comfort

7.8

Overall

8.0

Crew

8.5

Entertainment

7.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2026

STS - LAX

Enjoyed staff assistance from ticking thru tsa , boarding and in the plane Couldn’t pick a seat except upgrading

Related info for your journey

Find useful and relevant information for your journey from Key Largo to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly into for flights to San Diego from Key Largo?

    If you book a flight to San Diego from Key Largo, you will be flying to San Diego, which is the city’s only airport. San Diego (SAN) is located 2.6 mi from the center of San Diego. There are 7 flights from Key Largo to San Diego per day from 8 different airlines.

  • How popular is this Key Largo to San Diego flight route?

  • How long is the flight from Key Largo to San Diego?

    A quick flight from Key Largo to San Diego can take about 8h 26m. Alaska Airlines provides one of the quickest options available for as low as $328. The distance between Key Largo and San Diego is about 2262 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Key Largo to San Diego one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $78. However, be on the lookout for offers from Spirit Airlines and United Airlines, as they are both options that can get you from Key Largo to San Diego for a low price.

  • What are the most reliable airlines from Key Largo to San Diego?

    Before booking your flight to San Diego from Key Largo, check out the most reliable airlines to get you to your destination on time: Alaska Airlines (88%), American Airlines (87%), Finnair( 87%).

  • What are the cheapest flights from Key Largo to San Diego?

    Looking for the cheapest flight from Key Largo to San Diego? While on average our users pay $799, our data indicates the cheapest price to be $118. The most popular route (Miami - San Diego), is priced around $184.

  • Can I find deals for flights from Key Largo to San Diego that include hotel bookings?

    Yes. In addition to deals on Key Largo to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to San Diego.

  • Can I find deals for business class flights from Key Largo to San Diego?

    Yes. Cheapflights offers flight deals from Key Largo to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to San Diego?

    Currently, March is the cheapest month in which you can book a flight from Key Largo to San Diego (average of $119). Flying from Key Largo to San Diego in April is currently the most expensive (average of $211). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

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Alternative routes for Key Largo to San Diego

See prices for flight routes from nearby airports that may be better suited for you.

Top 8 airlines flying from Key Largo to San Diego

Discover the top 8 airlines that operate flights from Key Largo to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$100Average$212FlexibilityNo cancel feeOn-time65%
FrontierCheapest$155Average$239FlexibilityNo cancel feeOn-time62%
SouthwestCheapest$166Average$401FlexibilityNo cancel feeOn-time63%
Hawaiian AirlinesCheapest$199Average$357FlexibilityNo cancel feeOn-time85%
DeltaCheapest$204Average$353FlexibilityNo cancel feeOn-timeN/A
Alaska AirlinesCheapest$215Average$461FlexibilityNo cancel feeOn-time75%
American AirlinesCheapest$225Average$388FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$236Average$378FlexibilityNo cancel feeOn-time69%

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