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$134+ Cheap flights from Key Largo, FL to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/12. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — SAN
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to San Diego are usually found in April or May, booked 36 days in advance, depart on a Wednesday or Thursday and return on a Tuesday

Cheap flight deals from Key Largo to San Diego

Keep the following information in mind while searching for Key Largo to San Diego flight deals. Data was last updated June 12, 2025.

Round-trip from

$248
(Mytrip)

One-way from

$134
(Trip.com)

Popular in

March

Cheapest in

April

Average price

$428
From Key Largo to San Diego
Search Deals
One-way flight from Key Largo to San Diego
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High demand for flights, 1% potential price rise
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Key Largo to San Diego

Cheapest flights from Key Largo to San Diego
Explore the most affordable flight options available from Key Largo to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This Mytrip deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/117:00 amMIA - SAN
1 stop13h 55mSpirit Airlines
Mon 7/147:00 pmSAN - MIA
2 stops21h 19mSpirit Airlines
Deal found 6/12$248
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/252:30 pmMIA - SAN
1 stop11h 54mDelta
Mon 9/296:15 amSAN - MIA
1 stop8h 06mDelta
Deal found 6/11$257
This FlightHub deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/296:00 amMIA - SAN
1 stop7h 53mFrontier
Fri 9/56:25 amSAN - MIA
1 stop20h 54mFrontier
Deal found 6/12$260
This Gotogate deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/166:00 amMIA - SAN
1 stop16h 39mMultiple Airlines
Tue 7/16:15 amSAN - MIA
1 stop12h 00mMultiple Airlines
Deal found 6/11$264
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:24 pmMIA - SAN
1 stop8h 34mAmerican Airlines
Mon 9/2910:45 pmSAN - MIA
Nonstop4h 59mAmerican Airlines
Deal found 6/10$304
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1312:04 pmMIA - SAN
2 stops11h 21mUnited Airlines
Wed 9/1712:52 pmSAN - MIA
1 stop7h 52mUnited Airlines
Deal found 6/11$317
This Alaska Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/216:31 pmMIA - SAN
1 stop18h 43mAlaska Airlines
Mon 8/257:45 pmSAN - MIA
1 stop18h 46mAlaska Airlines
Deal found 6/10$330

Cheapflights Fare Finder

Customize your flight search to find flights from Key Largo to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Key Largo to San Diego that are best for you.

Fly from

Key Largo

Fly to

San Diego

Route

Depart

Return

Price

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 7/11

7:00 am-5:55 pm

1 stop13h 55m

San Diego

Mon 7/14

7:00 pm-7:19 pm

2 stops21h 19m

$248

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 7/2

8:55 pm-7:13 am

1 stop13h 18m

San Diego

Wed 8/13

7:04 pm-5:45 am

1 stop7h 41m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 8/29

6:00 am-10:53 am

1 stop7h 53m

San Diego

Fri 9/5

6:25 am-6:19 am

1 stop20h 54m

$260

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 8/21

2:45 pm-7:26 pm

1 stop7h 41m

San Diego

Mon 8/25

2:00 pm-12:24 am

1 stop7h 24m

$277

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 8/21

7:41 pm-9:54 pm

Nonstop5h 13m

San Diego

Mon 8/25

10:17 pm-6:20 am

Nonstop5h 03m

$311

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 8/21

6:31 pm-10:14 am

1 stop18h 43m

San Diego

Mon 8/25

7:45 pm-5:31 pm

1 stop18h 46m

$330

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sat 7/12

7:15 am-11:06 pm

1 stop18h 51m

$134

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sun 7/20

7:00 am-9:55 am

1 stop29h 55m

$135

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sun 9/7

6:00 am-11:08 am

1 stop8h 08m

$137

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 8/28

3:35 pm-11:44 pm

2 stops11h 09m

$144

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Showing 1-10 of 16 results
1
2

Best time to book a flight from Key Largo to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to San Diego

How far ahead should I book a flight from Key Largo to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to San Diego. Price data was last updated on June 9, 2025.

To ensure you get the cheapest price possible for a flight from Key Largo to San Diego, you should look to book at least 36 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Key Largo to San Diego?

Currently, August is the cheapest month in which you can book a flight from Key Largo to San Diego (average of $286). Flying from Key Largo to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to SAN?

Find hourly flight availability from Key Largo to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

When flying from Key Largo to San Diego, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Key Largo to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to San Diego. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to San Diego flight should consider departing on Tuesday at noon when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to San Diego

Explore weekly flight availability from Key Largo to San Diego. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated June 12, 2025.

The most flights from KE9 to SAN are scheduled on a Monday (4 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (4 on average).

Rainfall in San Diego by month

Plan your trip to San Diego by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in San Diego ranges from 0.0 - 2.3 inches per month. February is typically the wettest month, when rainfall can reach 2.3 in. July is typically the driest time to visit San Diego when rainfall is around 0.0 in.

Temperature in San Diego by month

Plan your trip to San Diego by taking into account the average temperature totals by month.

If weather is an important factor for your trip to San Diego, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 57.2 F).

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated June 12, 2025.
Read reviews from past customers who have flown Alaska Airlines, Southwest and Delta from Key Largo to San Diego. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Entertainment

7.1

Food

7.1

Boarding

8.1

Comfort

7.8

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Entertainment

7.1

Food

7.1

Boarding

8.1

Comfort

7.8

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Southwest
8.0
Very good
4,287 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Entertainment

7.1

Food

7.1

Boarding

8.1

Comfort

7.8

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,950 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Entertainment

7.1

Food

7.1

Boarding

8.1

Comfort

7.8

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,790 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Entertainment

7.1

Food

7.1

Boarding

8.1

Comfort

7.8

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
JetBlue
7.3
Good
2,925 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Overall

8.0

Entertainment

7.1

Food

7.1

Boarding

8.1

Comfort

7.8

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Key Largo?

    If you book a flight to San Diego from Key Largo, you will be flying to San Diego, which is the city’s only airport. San Diego (SAN) is located 2.6 mi from the center of San Diego. There are 4 flights from Key Largo to San Diego per day from 9 different airlines.

  • How popular is this Key Largo to San Diego flight route?

    The Key Largo to San Diego flight path was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Key Largo to San Diego one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $135. However, be on the lookout for offers from Frontier and United Airlines, as they are both options that can get you from Key Largo to San Diego for a low price.

  • What are the most reliable airlines from Key Largo to San Diego?

    Before booking your flight to San Diego from Key Largo, check out the most reliable airlines to get you to your destination on time: GOL (75%), Alaska Airlines (71%), American Airlines( 71%).

  • What are the cheapest flights from Key Largo to San Diego?

    Looking for the cheapest flight from Key Largo to San Diego? While on average our users pay $1,068, our data indicates the cheapest price to be $173. The most popular route (Miami - San Diego), is priced around $139.

  • Can I find deals for flights from Key Largo to San Diego that include hotel bookings?

    Yes. In addition to deals on Key Largo to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to San Diego.

  • Can I find deals for business class flights from Key Largo to San Diego?

    Yes. Cheapflights offers flight deals from Key Largo to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Key Largo to San Diego (average of $286). Flying from Key Largo to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Key Largo?

Book flights to Key Largo if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Imperial Beach
La Mesa
Alpine
Lemon Grove
Poway
Santee
Coronado

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Top 9 airlines flying from Key Largo to San Diego

Discover the top 9 airlines that operate flights from Key Largo to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$117Average$234FlexibilityNo cancel feeOn-time65%
FrontierCheapest$138Average$195FlexibilityNo cancel feeOn-time62%
JetBlueCheapest$176Average$344FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$196Average$371FlexibilityNo cancel feeOn-time71%
Alaska AirlinesCheapest$196Average$461FlexibilityNo cancel feeOn-time75%
DeltaCheapest$198Average$332FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$236Average$371FlexibilityNo cancel feeOn-time69%
Hawaiian AirlinesCheapest$237Average$394FlexibilityNo cancel feeOn-time85%
SouthwestCheapest$266Average$410FlexibilityNo cancel feeOn-time63%

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