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$140+ Cheap flights from Key Largo, FL to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/5. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — SAN
Jan 6 — Jan 131
Tue 1/6
Tue 1/13
1 adult, Economy
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Cheapflights Tip: The best prices from Key Largo to San Diego are usually found in April or February, booked 77 days in advance, depart on a Wednesday or Thursday and return on a Friday

Cheap flight deals from Key Largo to San Diego

Cheapest flights from Key Largo to San Diego
Explore the most affordable flight options available from Key Largo to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 7, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/309:05 pmMIA - SAN
2 stops29h 54mFrontier
Sat 1/103:29 pmSAN - MIA
1 stop17h 28mFrontier
Deal found 12/5$223
This Kiwi.com deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/309:05 pmMIA - SAN
2 stops29h 54mFrontier
Thu 1/86:25 amSAN - MIA
1 stop15h 48mFrontier
Deal found 12/5$225
This Frontier deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/207:05 amMIA - SAN
1 stop8h 33mFrontier
Wed 12/314:47 pmSAN - MIA
1 stop9h 13mFrontier
Deal found 12/6$228
This Kiwi.com deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/135:05 amMIA - SAN
2 stops18h 02mMultiple Airlines
Mon 12/156:25 amSAN - MIA
1 stop13h 53mMultiple Airlines
Deal found 12/6$230
This Priceline deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:05 amMIA - SAN
1 stop8h 06mFrontier
Tue 12/306:25 amSAN - MIA
1 stop8h 35mFrontier
Deal found 12/6$233
This Frontier deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/207:05 amMIA - SAN
1 stop8h 33mFrontier
Tue 12/306:25 amSAN - MIA
1 stop8h 35mFrontier
Deal found 12/6$234
This Kiwi.com deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/217:05 amMIA - SAN
2 stops33h 10mFrontier
Tue 1/207:00 amSAN - MIA
1 stop31h 12mFrontier
Deal found 12/6$236
This Frontier deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/197:05 amMIA - SAN
1 stop8h 33mFrontier
Wed 12/241:06 pmSAN - MIA
1 stop13h 29mFrontier
Deal found 12/6$237
This Frontier deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/207:05 amMIA - SAN
1 stop8h 33mFrontier
Fri 1/26:45 amSAN - MIA
1 stop13h 58mFrontier
Deal found 12/6$238
This Kiwi.com deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/157:05 amMIA - SAN
2 stops37h 48mFrontier
Thu 1/86:25 amSAN - MIA
1 stop15h 48mFrontier
Deal found 12/5$239
This Kiwi.com deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/207:05 amMIA - SAN
1 stop8h 33mFrontier
Wed 1/147:10 amSAN - MIA
2 stops29h 34mFrontier
Deal found 12/6$240
This Kiwi.com deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/319:26 pmMIA - SAN
2 stops29h 33mMultiple Airlines
Sat 1/103:29 pmSAN - MIA
1 stop17h 28mMultiple Airlines
Deal found 12/5$241

Find flight deals from Key Largo to San Diego

Keep the following information in mind while searching for Key Largo to San Diego flight deals. Data was last updated December 7, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$220
(Kiwi.com)

One-way from

$140
(Kiwi.com)

Popular in

June

Cheapest in

April

Average price

$471
Provider with most accurate pricing for Miami-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Miami-San Diego flights.
Search Deals
From Key Largo to San Diego
Search Deals
One-way flight from Key Largo to San Diego
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($8 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 7, 2025.
Use the filters below to find and compare flights from Key Largo to San Diego that are best for you.

Fly from

Key Largo

Fly to

San Diego

Route

Depart

Return

Price

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 1/23

5:30 am-12:08 am

2 stops21h 38m

San Diego

Wed 3/4

6:25 am-5:19 am

1 stop19h 54m

$236

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 1/8

9:30 am-12:27 pm

Nonstop5h 57m

San Diego

Sun 1/11

1:27 pm-9:26 pm

Nonstop4h 59m

$237

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 1/23

9:05 am-4:36 pm

1 stop10h 31m

San Diego

Tue 1/27

8:00 am-6:25 pm

1 stop7h 25m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 1/8

8:00 am-3:40 pm

1 stop10h 40m

San Diego

Sun 1/11

10:30 pm-10:40 am

1 stop9h 10m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 1/16

1:05 pm-6:36 pm

1 stop8h 31m

San Diego

Sun 1/18

12:11 pm-9:54 pm

1 stop6h 43m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 1/8

12:00 pm-6:40 pm

2 stops9h 40m

San Diego

Wed 1/14

7:30 am-6:35 pm

1 stop8h 05m

$262

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 1/8

4:51 pm-11:42 pm

2 stops9h 51m

San Diego

Wed 1/14

10:26 am-9:54 pm

1 stop8h 28m

$262

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sun 1/25

7:50 am-1:33 pm

1 stop8h 43m

San Diego

Thu 1/29

7:50 pm-6:35 am

1 stop7h 45m

$277

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 1/21

9:00 am-2:50 pm

1 stop8h 50m

San Diego

Sat 2/7

11:25 am-9:25 pm

1 stop7h 00m

$277

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 1/23

12:02 pm-7:01 pm

1 stop9h 59m

San Diego

Wed 3/4

2:15 pm-12:53 am

1 stop7h 38m

$297

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/7

Showing 1-10 of 19 results
1
2

Best time to book a flight from Key Largo to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to San Diego

How far ahead should I book a flight from Key Largo to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Key Largo to San Diego. Price data was last updated on December 5, 2025.

To ensure you get the cheapest price possible for a flight from Key Largo to San Diego, you should look to book at least 49 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Key Largo to San Diego?

Currently, March is the cheapest month in which you can book a flight from Key Largo to San Diego (average of $118). Flying from Key Largo to San Diego in April is currently the most expensive (average of $222). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to SAN?

Find hourly flight availability from Key Largo to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 7, 2025.

It’s typically best to fly out from Key Largo to San Diego at noon. Doing so could potentially save you 22% on the flight price compared to flying in the morning, which is usually more expensive.

What is the cheapest day to fly from Key Largo to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to San Diego. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to San Diego flight should consider departing on Sunday at noon when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to San Diego

Explore weekly flight availability from Key Largo to San Diego. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated December 7, 2025.

The most flights from KE9 to SAN are scheduled on a Monday (6 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (5 on average).

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated December 7, 2025.
Read through reviews of airlines operating flights from Key Largo to San Diego, such as Alaska Airlines, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
11,412 reviews

Comfort

7.8

Food

7.1

Entertainment

7.0

Overall

8.0

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Alaska Airlines
8.0
Very good
11,412 reviews
Alaska Airlines
8.0
Very good
11,412 reviews

Comfort

7.8

Food

7.1

Entertainment

7.0

Overall

8.0

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Delta
7.9
Good
8,013 reviews
Alaska Airlines
8.0
Very good
11,412 reviews

Comfort

7.8

Food

7.1

Entertainment

7.0

Overall

8.0

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
United Airlines
7.4
Good
9,076 reviews
Alaska Airlines
8.0
Very good
11,412 reviews

Comfort

7.8

Food

7.1

Entertainment

7.0

Overall

8.0

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
American Airlines
7.2
Good
11,042 reviews
Alaska Airlines
8.0
Very good
11,412 reviews

Comfort

7.8

Food

7.1

Entertainment

7.0

Overall

8.0

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Frontier
5.8
Fair
3,088 reviews
Alaska Airlines
8.0
Very good
11,412 reviews

Comfort

7.8

Food

7.1

Entertainment

7.0

Overall

8.0

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Key Largo?

    If you book a flight to San Diego from Key Largo, you will be flying to San Diego, which is the city’s only airport. San Diego (SAN) is located 2.6 mi from the center of San Diego. There are 5 flights from Key Largo to San Diego per day from 9 different airlines.

  • How popular is this Key Largo to San Diego flight route?

    The Key Largo to San Diego flight path was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Key Largo to San Diego?

    A quick flight from Key Largo to San Diego can take about 5h 57m. Frontier provides one of the quickest options available for as low as $237. The distance between Key Largo and San Diego is about 2262 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Key Largo to San Diego one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $75. However, be on the lookout for offers from Frontier and United Airlines, as they are both options that can get you from Key Largo to San Diego for a low price.

  • What are the most reliable airlines from Key Largo to San Diego?

    Before booking your flight to San Diego from Key Largo, check out the most reliable airlines to get you to your destination on time: GOL (90%), Alaska Airlines (82%), American Airlines( 76%).

  • What are the cheapest flights from Key Largo to San Diego?

    Looking for the cheapest flight from Key Largo to San Diego? While on average our users pay $920, our data indicates the cheapest price to be $128. The most popular route (Miami - San Diego), is priced around $174.

  • Can I find deals for flights from Key Largo to San Diego that include hotel bookings?

    Yes. In addition to deals on Key Largo to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to San Diego.

  • Can I find deals for business class flights from Key Largo to San Diego?

    Yes. Cheapflights offers flight deals from Key Largo to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to San Diego?

    Currently, March is the cheapest month in which you can book a flight from Key Largo to San Diego (average of $118). Flying from Key Largo to San Diego in April is currently the most expensive (average of $222). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
La Mesa
Poway
Lemon Grove
Julian
National City

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Top 9 airlines flying from Key Largo to San Diego

Discover the top 9 airlines that operate flights from Key Largo to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 7, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$108Average$218FlexibilityNo cancel feeOn-time65%
FrontierCheapest$164Average$233FlexibilityNo cancel feeOn-time62%
SouthwestCheapest$166Average$406FlexibilityNo cancel feeOn-time63%
Hawaiian AirlinesCheapest$199Average$357FlexibilityNo cancel feeOn-time85%
Alaska AirlinesCheapest$216Average$458FlexibilityNo cancel feeOn-time75%
American AirlinesCheapest$231Average$389FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$236Average$375FlexibilityNo cancel feeOn-time69%
DeltaCheapest$246Average$356FlexibilityNo cancel feeOn-timeN/A
JetBlueCheapest$266Average$404FlexibilityNo cancel feeOn-time62%

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