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$127+ Cheap flights from Florida Keys to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/20. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SAN
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Florida Keys to San Diego

Keep the following information in mind while searching for Florida Keys to San Diego flight deals. Data was last updated May 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$252
(Mytrip)

One-way from

$128
(Cheapflightsfares)
Provider with most accurate pricing for Key West-San Diego flight deals.
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Provider most trusted by Cheapflights users for Key West-San Diego flights.
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From Florida Keys to San Diego
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One-way flight from Florida Keys to San Diego
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Find flight deals from Florida Keys to San Diego

Cheapest flights from Florida Keys to San Diego
Explore the most affordable flight options available from Florida Keys to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/248:55 pmMIA - SAN
1 stop13h 18mSpirit Airlines
Sun 6/18:48 pmSAN - MIA
2 stops14h 22mSpirit Airlines
Deal found 4/30$252
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/135:30 amMIA - SAN
1 stop7h 09mDelta
Mon 6/169:40 pmSAN - MIA
1 stop10h 17mDelta
Deal found 4/29$257
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/248:15 pmMIA - SAN
Nonstop5h 22mAmerican Airlines
Sun 6/110:25 pmSAN - MIA
Nonstop4h 47mAmerican Airlines
Deal found 4/30$258
This eDestinos deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/96:00 amMIA - SAN
1 stop21h 13mFrontier
Fri 5/168:22 amSAN - MIA
2 stops42h 00mFrontier
Deal found 4/30$268
This eDestinos deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/307:10 amMIA - SAN
1 stop7h 46mMultiple Airlines
Mon 6/29:07 pmSAN - MIA
2 stops31h 58mMultiple Airlines
Deal found 4/30$282
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/124:15 pmMIA - SAN
1 stop8h 35mSouthwest
Mon 6/168:55 pmSAN - MIA
2 stops15h 45mSouthwest
Deal found 4/30$338
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/36:00 amMIA - SAN
1 stop10h 02mUnited Airlines
Wed 6/41:30 pmSAN - MIA
2 stops13h 15mUnited Airlines
Deal found 4/29$358
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/157:00 amEYW - SAN
1 stop8h 33mDelta
Mon 5/1910:30 pmSAN - EYW
1 stop9h 21mDelta
Deal found 4/30$369
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1511:28 amEYW - SAN
2 stops9h 58mAmerican Airlines
Mon 5/1910:49 pmSAN - EYW
1 stop10h 21mAmerican Airlines
Deal found 4/30$374
This Alaska Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/235:55 pmMIA - SAN
1 stop17h 57mAlaska Airlines
Sat 10/258:50 pmSAN - MIA
1 stop17h 05mAlaska Airlines
Deal found 4/29$396
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/158:45 amEYW - SAN
2 stops16h 29mUnited Airlines
Mon 5/197:40 pmSAN - EYW
3 stops19h 25mUnited Airlines
Deal found 4/30$537

Cheapflights Fare Finder

Customize your flight search to find flights from Florida Keys to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Florida Keys to San Diego that are best for you.

Fly from

Florida Keys

Fly to

San Diego

Route

Depart

Return

Price

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sat 5/24

8:55 pm-7:13 am

1 stop13h 18m

San Diego

Sun 6/1

8:48 pm-2:10 pm

2 stops14h 22m

$252

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 6/13

5:30 am-9:39 am

1 stop7h 09m

San Diego

Mon 6/16

9:40 pm-10:57 am

1 stop10h 17m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sat 5/24

8:15 pm-10:37 pm

Nonstop5h 22m

San Diego

Sun 6/1

10:25 pm-6:12 am

Nonstop4h 47m

$258

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 5/9

6:00 am-12:13 am

1 stop21h 13m

San Diego

Fri 5/16

8:22 am-5:22 am

2 stops42h 00m

$268

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 5/30

7:10 am-11:56 am

1 stop7h 46m

San Diego

Mon 6/2

9:07 pm-8:05 am

2 stops31h 58m

$282

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 6/12

4:15 pm-9:50 pm

1 stop8h 35m

San Diego

Mon 6/16

8:55 pm-3:40 pm

2 stops15h 45m

$338

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 6/3

6:00 am-1:02 pm

1 stop10h 02m

San Diego

Wed 6/4

1:30 pm-5:45 am

2 stops13h 15m

$358

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 5/15

7:00 am-12:33 pm

1 stop8h 33m

San Diego

Mon 5/19

10:30 pm-10:51 am

1 stop9h 21m

$369

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 5/15

11:28 am-6:26 pm

2 stops9h 58m

San Diego

Mon 5/19

10:49 pm-12:10 pm

1 stop10h 21m

$374

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 5/23

6:21 pm-9:19 pm

2 stops29h 58m

San Diego

Wed 5/28

4:59 pm-5:21 pm

1 stop21h 22m

$448

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Showing 1-10 of 21 results
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Best time to book a flight from Florida Keys to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to San Diego

What is the cheapest time of day to fly from EOA to SAN?

Find hourly flight availability from Florida Keys to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida Keys to San Diego as you normally would.

Rainfall in San Diego by month

Plan your trip to San Diego by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in San Diego ranges from 0.0 - 2.3 inches per month. February is typically the wettest month, when rainfall can reach 2.3 in. July is typically the driest time to visit San Diego when rainfall is around 0.0 in.

Temperature in San Diego by month

Plan your trip to San Diego by taking into account the average temperature totals by month.

If weather is an important factor for your trip to San Diego, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 57.2 F).

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated May 1, 2025.
See what other customers who have flown with Alaska Airlines, Southwest and Delta from Florida Keys to San Diego have to say. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,968 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
9,968 reviews
Alaska Airlines
8.0
Very good
9,968 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Southwest
8.0
Very good
4,294 reviews
Alaska Airlines
8.0
Very good
9,968 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,934 reviews
Alaska Airlines
8.0
Very good
9,968 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,696 reviews
Alaska Airlines
8.0
Very good
9,968 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
JetBlue
7.3
Good
2,924 reviews
Alaska Airlines
8.0
Very good
9,968 reviews

Overall

8.0

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Florida Keys?

    San Diego (SAN), located 2.6 mi from the city center, is the airport you fly into when you book flights from Florida Keys to San Diego.

  • What are the cheapest airlines to fly from Florida Keys to San Diego one-way?

    The cheapest airlines for a one-way flight from Florida Keys to San Diego are Frontier ($128), Delta ($129), and Spirit Airlines ($132).

  • Can I find deals for flights from Florida Keys to San Diego that include hotel bookings?

    Yes. In addition to deals on Florida Keys to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to San Diego.

  • Can I find deals for business class flights from Florida Keys to San Diego?

    Yes. Cheapflights offers flight deals from Florida Keys to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Florida Keys to San Diego (average of $286). Flying from Florida Keys to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florida Keys?

Book flights to Florida Keys if you plan to visit one of these locations
El Cajon
Chula Vista
Lemon Grove
National City
Imperial Beach
La Mesa
Alpine
Poway
Santee
Coronado

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Alternative routes for Florida Keys to San Diego

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Top airline flying from Florida Keys to San Diego

Discover the top airline that operate flights from Florida Keys to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$299Average$447FlexibilityNo cancel feeOn-time71%

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