What are the cheapest airlines to fly from Florida Keys to San Diego one-way?

The cheapest airlines for a one-way flight from Florida Keys to San Diego are Frontier ($124), Delta ($129), and Spirit Airlines ($132).

What is the cheapest month to book a flight from Florida Keys to San Diego?

Currently, August is the cheapest month in which you can book a flight from Florida Keys to San Diego (average of $286). Flying from Florida Keys to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

In terms of precipitation, rainfall in San Diego ranges from 0.0 - 2.3 inches per month. February is typically the wettest month, when rainfall can reach 2.3 in. July is typically the driest time to visit San Diego when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Diego, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 57.2 F).

How far in advance should I book a flight from Florida Keys to San Diego?

Find a great deal and save up to 44% by booking at least 37 days prior to your desired departure date, rather than waiting until the week of travel. According to our data, there are a number of flights available from Florida Keys to San Diego within the next two weeks, with the cheapest ticket starting at $379.

What is the cheapest month to fly from Florida Keys to San Diego?

April is one of the best times of the year to fly to San Diego from Florida Keys. Prices for April average $408 per person but you can even find prices for as low as $231. The most expensive prices can be found in the month of March. Opting for a April flight can save you 13% on your journey compared to booking in March

What airport do you fly into for flights to San Diego from Florida Keys?

San Diego (SAN), located 2.6 mi from the city center, is the airport you fly into when you book flights from Florida Keys to San Diego.

Can I find deals for flights from Florida Keys to San Diego that include hotel bookings?

Yes. In addition to deals on Florida Keys to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Florida Keys to San Diego?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to San Diego.

Can I find deals for business class flights from Florida Keys to San Diego?

Yes. Cheapflights offers flight deals from Florida Keys to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$124+ Flights from Florida Keys to San Diego

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Cheap flight deals from Florida Keys to San Diego

Round-trip from	$241 (FlightHub)
One-way from	$124 (Priceline)

From Florida Keys to San Diego

Search Deals

One-way flight from Florida Keys to San Diego

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Find flight deals from Florida Keys to San Diego

Cheapest flights from Florida Keys to San Diego
Explore the most affordable flight options available from Florida Keys to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Tue 7/86:00 amMIA - SAN

1 stop20h 02mMultiple Airlines

Wed 7/167:00 pmSAN - MIA

1 stop7h 38mMultiple Airlines

Deal found 7/1

$240

Fri 8/226:00 amMIA - SAN

1 stop7h 53mFrontier

Mon 8/256:25 amSAN - MIA

2 stops15h 29mFrontier

Deal found 6/30

$242

Thu 8/148:23 pmMIA - SAN

1 stop13h 58mSpirit Airlines

Sun 8/176:15 amSAN - MIA

1 stop10h 08mSpirit Airlines

Deal found 7/1

$244

Sat 8/95:30 amMIA - SAN

1 stop6h 53mDelta

Sat 8/162:00 pmSAN - MIA

1 stop7h 24mDelta

Deal found 7/1

$257

Tue 7/1511:18 amEYW - SAN

2 stops11h 00mAmerican Airlines

Sat 7/1910:39 pmSAN - EYW

1 stop10h 21mAmerican Airlines

Deal found 6/29

$374

Mon 7/1410:02 amEYW - SAN

2 stops26h 53mMultiple Airlines

Fri 7/185:00 pmSAN - EYW

2 stops19h 08mMultiple Airlines

Deal found 6/28

$507

Mon 7/146:27 pmEYW - SAN

1 stop7h 54mDelta

Fri 7/186:15 amSAN - EYW

1 stop8h 17mDelta

Deal found 6/28

$806

Best flights from Florida Keys to San Diego
Discover carefully curated flight deals from Florida Keys to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 1, 2025.

Fri 7/187:00 amMIA - SAN

1 stop13h 55mMultiple Airlines

Mon 7/216:25 amSAN - MIA

1 stop21h 05mMultiple Airlines

Deal found 7/1

$241

Fri 8/226:00 amMIA - SAN

1 stop7h 53mFrontier

Mon 8/256:25 amSAN - MIA

2 stops15h 29mFrontier

Deal found 6/30

$242

Thu 8/148:23 pmMIA - SAN

1 stop13h 58mSpirit Airlines

Sun 8/176:15 amSAN - MIA

1 stop10h 08mSpirit Airlines

Deal found 7/1

$244

Sat 8/95:30 amMIA - SAN

1 stop6h 53mDelta

Sat 8/162:00 pmSAN - MIA

1 stop7h 24mDelta

Deal found 7/1

$257

Tue 7/1511:18 amEYW - SAN

2 stops11h 00mAmerican Airlines

Sat 7/1910:39 pmSAN - EYW

1 stop10h 21mAmerican Airlines

Deal found 6/29

$374

Wed 7/1610:02 amEYW - SAN

3 stops26h 53mMultiple Airlines

Sun 7/209:40 pmSAN - EYW

2 stops12h 27mMultiple Airlines

Deal found 7/1

$510

Last-minute flights from Florida Keys to San Diego
Discover last-minute flight deals from Florida Keys to San Diego. Data last updated July 1, 2025 and is based on user searches.

Tue 7/86:00 amMIA - SAN

1 stop20h 02mMultiple Airlines

Wed 7/167:00 pmSAN - MIA

1 stop7h 38mMultiple Airlines

Deal found 7/1

$240

Tue 7/88:55 pmMIA - SAN

1 stop16h 00mSpirit Airlines

Sat 7/197:00 pmSAN - MIA

1 stop7h 38mSpirit Airlines

Deal found 6/30

$260

Thu 7/107:15 amMIA - SAN

1 stop7h 49mFrontier

Sun 7/2012:59 pmSAN - MIA

1 stop13h 46mFrontier

Deal found 6/30

$250

Mon 7/1410:02 amEYW - SAN

2 stops26h 53mMultiple Airlines

Fri 7/185:00 pmSAN - EYW

2 stops19h 08mMultiple Airlines

Deal found 6/28

$507

Mon 7/146:27 pmEYW - SAN

1 stop7h 54mDelta

Fri 7/186:15 amSAN - EYW

1 stop8h 17mDelta

Deal found 6/28

$806

Tue 7/1511:18 amEYW - SAN

2 stops11h 00mAmerican Airlines

Sat 7/1910:39 pmSAN - EYW

1 stop10h 21mAmerican Airlines

Deal found 6/29

$374

Sat 8/95:30 amMIA - SAN

1 stop6h 53mDelta

Sat 8/165:00 pmSAN - MIA

1 stop10h 27mDelta

Deal found 7/1

$257

Thu 8/148:23 pmMIA - SAN

1 stop13h 58mSpirit Airlines

Sun 8/176:15 amSAN - MIA

1 stop10h 08mSpirit Airlines

Deal found 7/1

$244

Fri 8/226:00 amMIA - SAN

1 stop7h 53mFrontier

Mon 8/256:25 amSAN - MIA

2 stops15h 29mFrontier

Deal found 6/30

$242

One-way flights from Florida Keys to San Diego
Search for one-way flight options from Florida Keys to San Diego. Find affordable one-way fares based on user searches. Data last updated July 1, 2025.

Sat 7/196:00 amMIA - SAN

1 stop8h 10mFrontier

Deal found 7/1

$124

Sat 8/25:30 amMIA - SAN

1 stop6h 53mDelta

Deal found 6/30

$129

Wed 7/2311:54 amMIA - SAN

2 stops14h 12mSpirit Airlines

Deal found 7/1

$132

Sat 9/2712:06 pmMIA - SAN

2 stops10h 40mUnited Airlines

Deal found 6/29

$134

Sun 8/317:41 pmMIA - SAN

Nonstop5h 13mAmerican Airlines

Deal found 6/30

$174

Mon 8/410:23 amEYW - SAN

2 stops15h 43mMultiple Airlines

Deal found 6/28

$278

Mon 8/46:27 pmEYW - SAN

1 stop7h 54mDelta

Deal found 6/28

$283

Fri 7/254:48 pmEYW - SAN

2 stops10h 21mAmerican Airlines

Deal found 6/30

$823

Fri 7/252:12 pmEYW - SAN

3 stops45h 57mUnited Airlines

Deal found 6/30

$1,579

Cheapflights Fare Finder

Use the filters below to find and compare flights from Florida Keys to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 7/8

6:00 am-11:02 pm

1 stop20h 02m

San Diego

Wed 7/16

7:00 pm-5:38 am

1 stop7h 38m

$240

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 8/22

6:00 am-10:53 am

1 stop7h 53m

San Diego

Mon 8/25

6:25 am-12:54 am

2 stops15h 29m

$242

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 8/14

8:23 pm-7:21 am

1 stop13h 58m

San Diego

Sun 8/17

6:15 am-7:23 pm

1 stop10h 08m

$244

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sat 8/9

5:30 am-9:23 am

1 stop6h 53m

San Diego

Sat 8/16

5:00 pm-6:27 am

1 stop10h 27m

$257

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Tue 7/15

11:18 am-7:18 pm

2 stops11h 00m

San Diego

Sat 7/19

10:39 pm-12:00 pm

1 stop10h 21m

$374

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Mon 7/14

10:02 am-9:55 am

2 stops26h 53m

San Diego

Fri 7/18

5:00 pm-3:08 pm

2 stops19h 08m

$507

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Mon 7/14

6:27 pm-11:21 pm

1 stop7h 54m

San Diego

Fri 7/18

6:15 am-5:32 pm

1 stop8h 17m

$806

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sat 7/19

6:00 am-11:10 am

1 stop8h 10m

$124

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Mon 7/14

7:00 am-5:55 pm

1 stop13h 55m

$125

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sat 8/2

5:30 am-9:23 am

1 stop6h 53m

$129

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Showing 1-10 of 16 results

Best time to book a flight from Florida Keys to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Florida Keys with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to San Diego

What is the cheapest time of day to fly from EOA to SAN?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida Keys to San Diego as you normally would.

Reviews of airlines servicing San Diego

See what other customers who have flown with Delta, United Airlines, and American Airlines from Florida Keys to San Diego have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,973 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta

8.0

Very good

7,973 reviews

Delta

8.0

Very good

7,973 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines

7.4

Good

8,858 reviews

Delta

8.0

Very good

7,973 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,973 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Spirit Airlines

6.3

Okay

8,101 reviews

Delta

8.0

Very good

7,973 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Frontier

5.9

Fair

3,291 reviews

Delta

8.0

Very good

7,973 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

What airport do you fly into for flights to San Diego from Florida Keys?
San Diego (SAN), located 2.6 mi from the city center, is the airport you fly into when you book flights from Florida Keys to San Diego.
What are the cheapest airlines to fly from Florida Keys to San Diego one-way?
The cheapest airlines for a one-way flight from Florida Keys to San Diego are Frontier ($124), Delta ($129), and Spirit Airlines ($132).
Can I find deals for flights from Florida Keys to San Diego that include hotel bookings?
Yes. In addition to deals on Florida Keys to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Florida Keys to San Diego?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to San Diego.
Can I find deals for business class flights from Florida Keys to San Diego?
Yes. Cheapflights offers flight deals from Florida Keys to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Florida Keys to San Diego?
Currently, August is the cheapest month in which you can book a flight from Florida Keys to San Diego (average of $286). Flying from Florida Keys to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

El Cajon

Chula Vista

Coronado

National City

Lemon Grove

Imperial Beach

La Mesa

Poway

Alpine

Santee

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Florida Keys to San Diego

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$299	Average$468	FlexibilityNo cancel fee	On-time71%

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$124+ Cheap flights from Florida Keys to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/19. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Florida Keys to San Diego with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Florida Keys to San Diego

Keep the following information in mind while searching for Florida Keys to San Diego flight deals. Data was last updated July 1, 2025.

Round-trip from

One-way from

Find flight deals from Florida Keys to San Diego

Cheapest flights from Florida Keys to San DiegoExplore the most affordable flight options available from Florida Keys to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Explore the most affordable flight options available from Florida Keys to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Florida Keys to San Diego that are best for you.

Best time to book a flight from Florida Keys to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Florida Keys with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to San Diego

What is the cheapest time of day to fly from EOA to SAN?

Find hourly flight availability from Florida Keys to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 1, 2025.

Reviews of airlines servicing San Diego

See what other customers who have flown with Delta, United Airlines, and American Airlines from Florida Keys to San Diego have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to San Diego from Florida Keys?

What are the cheapest airlines to fly from Florida Keys to San Diego one-way?

Can I find deals for flights from Florida Keys to San Diego that include hotel bookings?

How can I find direct flights from Florida Keys to San Diego?

Can I find deals for business class flights from Florida Keys to San Diego?

What is the cheapest month to book a flight from Florida Keys to San Diego?

Traveling to a place near Florida Keys?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Florida Keys to San Diego

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Florida Keys to San Diego

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Travel Smart

Cheapest flights from Florida Keys to San Diego
Explore the most affordable flight options available from Florida Keys to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.