$154+ Cheap flights from Florida Keys to San Diego (SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SAN
May 9 — May 161
Round-trip
1 adult, Economy
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Find cheap flights from Florida Keys to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Florida Keys to San DiegoExplore the most affordable flight options available from Florida Keys to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.
Explore the most affordable flight options available from Florida Keys to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/171:15 pm
MIA
- SAN
2 stops13h 44m
Frontier
Sun 4/197:20 am
SAN
- MIA
1 stop10h 59m
Frontier
Deal found 4/5![Frontier logo]()
$378
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/208:40 am
MIA
- SAN
Nonstop5h 36m
American Airlines
Tue 5/2612:36 pm
SAN
- MIA
Nonstop5h 19m
American Airlines
Deal found 4/6![American Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/208:40 am
MIA
- SAN
Nonstop5h 36m
American Airlines
Wed 5/2710:25 pm
SAN
- MIA
Nonstop5h 11m
American Airlines
Deal found 4/5![American Airlines logo]()
$380
This Super.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/95:50 am
MIA
- SAN
1 stop21h 15m
Frontier
Sun 4/129:28 pm
SAN
- MIA
1 stop29h 21m
Frontier
Deal found 4/6![Frontier logo]()
$381
This Gotogate deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:50 am
MIA
- SAN
1 stop21h 12m
Frontier
Sun 4/129:28 pm
SAN
- MIA
1 stop29h 21m
Frontier
Deal found 4/5![Frontier logo]()
$382
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:50 pm
MIA
- SAN
Nonstop5h 38m
American Airlines
Wed 5/2012:53 pm
SAN
- MIA
Nonstop5h 06m
American Airlines
Deal found 4/8![American Airlines logo]()
$383
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/152:09 pm
MIA
- SAN
2 stops32h 52m
Multiple Airlines
Mon 4/206:25 am
SAN
- MIA
1 stop19h 40m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$384
This eDestinos deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/208:47 pm
MIA
- SAN
2 stops27h 25m
Frontier
Wed 5/276:25 am
SAN
- MIA
2 stops21h 35m
Frontier
Deal found 4/5![Frontier logo]()
$386
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/76:00 am
MIA
- SAN
1 stop15h 30m
Frontier
Fri 6/128:29 pm
SAN
- MIA
2 stops24h 05m
Frontier
Deal found 4/8![Frontier logo]()
$387
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/175:05 am
MIA
- SAN
1 stop9h 19m
Multiple Airlines
Tue 9/86:25 am
SAN
- MIA
2 stops21h 51m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$388
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:05 am
MIA
- SAN
1 stop9h 19m
Multiple Airlines
Thu 5/141:38 pm
SAN
- MIA
2 stops13h 00m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$390
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:45 am
EYW
- SAN
1 stop8h 08m
American Airlines
Sat 4/2510:05 pm
SAN
- EYW
1 stop9h 49m
American Airlines
Deal found 4/4![American Airlines logo]()
$412
Best flights from Florida Keys to San DiegoDiscover carefully curated flight deals from Florida Keys to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 9, 2026.
Discover carefully curated flight deals from Florida Keys to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 9, 2026.
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/233:58 pm
EYW
- SAN
2 stops9h 02m
American Airlines
Sat 4/259:12 am
SAN
- EYW
2 stops10h 24m
American Airlines
Deal found 4/4![American Airlines logo]()
$423
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:30 pm
MIA
- SAN
1 stop7h 45m
Delta
Tue 5/268:00 am
SAN
- MIA
1 stop8h 58m
Delta
Deal found 4/4![Delta logo]()
$432
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:00 pm
MIA
- SAN
2 stops9h 05m
Southwest
Mon 6/810:40 pm
SAN
- MIA
2 stops12h 45m
Southwest
Deal found 4/6![Southwest logo]()
$447
This Alaska Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/69:19 am
MIA
- SAN
Nonstop5h 34m
Alaska Airlines
Sat 5/912:53 pm
SAN
- MIA
Nonstop5h 06m
Alaska Airlines
Deal found 4/5![Alaska Airlines logo]()
$489
This United Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/304:47 pm
EYW
- SAN
1 stop7h 38m
United Airlines
Mon 5/410:20 pm
SAN
- EYW
1 stop12h 23m
United Airlines
Deal found 4/3![United Airlines logo]()
$499
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/167:00 am
MIA
- SAN
1 stop8h 17m
Delta
Tue 6/237:13 pm
SAN
- MIA
1 stop7h 29m
Delta
Deal found 4/8![Delta logo]()
$440
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/811:56 am
EYW
- SAN
1 stop10h 04m
American Airlines
Fri 5/159:12 am
SAN
- EYW
2 stops10h 46m
American Airlines
Deal found 4/8![American Airlines logo]()
$460
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:10 pm
MIA
- SAN
2 stops8h 30m
Southwest
Sat 7/116:25 am
SAN
- MIA
2 stops13h 35m
Southwest
Deal found 4/7![Southwest logo]()
$475
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/232:40 pm
EYW
- SAN
1 stop9h 10m
Delta
Sat 4/2510:30 pm
SAN
- EYW
1 stop9h 16m
Delta
Deal found 4/6![Delta logo]()
$449
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:30 am
MIA
- SAN
1 stop16h 42m
United Airlines
Tue 9/810:40 pm
SAN
- MIA
2 stops13h 12m
United Airlines
Deal found 4/4![United Airlines logo]()
$512
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:35 am
MIA
- SAN
2 stops8h 20m
Southwest
Mon 7/610:40 pm
SAN
- MIA
1 stop14h 10m
Southwest
Deal found 4/5![Southwest logo]()
$476
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:45 am
EYW
- SAN
1 stop7h 31m
American Airlines
Fri 5/159:12 am
SAN
- EYW
2 stops10h 46m
American Airlines
Deal found 4/8![American Airlines logo]()
$477
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/274:15 pm
MIA
- SAN
2 stops9h 50m
Southwest
Sat 8/110:40 pm
SAN
- MIA
1 stop12h 50m
Southwest
Deal found 4/5![Southwest logo]()
$476
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/178:12 am
MIA
- SAN
1 stop9h 59m
Delta
Wed 6/241:02 pm
SAN
- MIA
1 stop7h 39m
Delta
Deal found 4/8![Delta logo]()
$490
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:00 pm
MIA
- SAN
2 stops9h 05m
Southwest
Sun 8/28:55 pm
SAN
- MIA
2 stops15h 25m
Southwest
Deal found 4/8![Southwest logo]()
$481
Last-minute flights from Florida Keys to San DiegoDiscover last-minute flight deals from Florida Keys to San Diego. Data last updated April 9, 2026 and is based on user searches.
Discover last-minute flight deals from Florida Keys to San Diego. Data last updated April 9, 2026 and is based on user searches.
This Super.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/95:50 am
MIA
- SAN
1 stop21h 15m
Frontier
Sun 4/129:28 pm
SAN
- MIA
1 stop29h 21m
Frontier
Deal found 4/6![Frontier logo]()
$381
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/152:09 pm
MIA
- SAN
2 stops32h 52m
Multiple Airlines
Mon 4/206:25 am
SAN
- MIA
1 stop19h 40m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$384
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/171:15 pm
MIA
- SAN
2 stops13h 44m
Frontier
Sun 4/197:20 am
SAN
- MIA
1 stop10h 59m
Frontier
Deal found 4/5![Frontier logo]()
$378
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:45 am
EYW
- SAN
1 stop8h 08m
American Airlines
Sat 4/2510:05 pm
SAN
- EYW
1 stop9h 49m
American Airlines
Deal found 4/4![American Airlines logo]()
$412
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:50 pm
MIA
- SAN
Nonstop5h 38m
American Airlines
Wed 5/2012:53 pm
SAN
- MIA
Nonstop5h 06m
American Airlines
Deal found 4/8![American Airlines logo]()
$383
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:05 am
MIA
- SAN
1 stop9h 19m
Multiple Airlines
Thu 5/141:38 pm
SAN
- MIA
2 stops13h 00m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$390
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/175:05 am
MIA
- SAN
1 stop9h 19m
Multiple Airlines
Thu 5/2812:09 pm
SAN
- MIA
1 stop19h 18m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$387
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/175:05 am
MIA
- SAN
1 stop9h 19m
Multiple Airlines
Tue 9/86:25 am
SAN
- MIA
2 stops21h 51m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$388
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/208:40 am
MIA
- SAN
Nonstop5h 36m
American Airlines
Tue 5/2612:36 pm
SAN
- MIA
Nonstop5h 19m
American Airlines
Deal found 4/6![American Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/208:40 am
MIA
- SAN
Nonstop5h 36m
American Airlines
Wed 5/2710:25 pm
SAN
- MIA
Nonstop5h 11m
American Airlines
Deal found 4/5![American Airlines logo]()
$380
This eDestinos deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/208:47 pm
MIA
- SAN
2 stops27h 25m
Frontier
Wed 5/276:25 am
SAN
- MIA
2 stops21h 35m
Frontier
Deal found 4/5![Frontier logo]()
$386
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:30 am
MIA
- SAN
1 stop20h 20m
Frontier
Tue 5/266:25 am
SAN
- MIA
1 stop20h 08m
Frontier
Deal found 4/4![Frontier logo]()
$382
One-way flights from Florida Keys to San DiegoSearch for one-way flight options from Florida Keys to San Diego. Find affordable one-way fares based on user searches. Data last updated April 9, 2026.
Search for one-way flight options from Florida Keys to San Diego. Find affordable one-way fares based on user searches. Data last updated April 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2711:46 am
EYW
- SAN
3 stops27h 57m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$154
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/281:01 pm
EYW
- SAN
3 stops46h 33m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/2510:31 am
EYW
- SAN
2 stops25h 11m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$168
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:30 am
MIA
- SAN
1 stop29h 12m
Frontier
Deal found 4/7![Frontier logo]()
$188
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:21 pm
EYW
- SAN
1 stop7h 58m
American Airlines
Deal found 4/8![American Airlines logo]()
$188
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/89:01 am
EYW
- SAN
2 stops41h 52m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$190
This eDestinos deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/288:30 am
MIA
- SAN
2 stops51h 39m
Frontier
Deal found 4/8![Frontier logo]()
$191
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/183:20 pm
MIA
- SAN
2 stops20h 14m
Frontier
Deal found 4/8![Frontier logo]()
$192
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/268:53 pm
MIA
- SAN
3 stops38h 49m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$193
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2811:24 am
EYW
- SAN
2 stops11h 45m
American Airlines
Deal found 4/7![American Airlines logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:15 pm
MIA
- SAN
1 stop26h 44m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$194
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/28:55 pm
MIA
- SAN
2 stops38h 47m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$196
Find flight deals from Florida Keys to San Diego
Keep the following information in mind while searching for Florida Keys to San Diego flight deals. Data was last updated April 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $378 (American Airlines) |
One-way from | $154 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Florida Keys to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
Use the filters below to find and compare flights from Florida Keys to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Key WestSan Diego
EYW - SAN
EYWSAN
Key West
Thu 4/23
3:58 pm-10:00 pm
2 stops9h 02m
San Diego
Sat 4/25
9:12 am-10:36 pm
2 stops10h 24m
$423
MiamiSan Diego
MIA - SAN
MIASAN
Miami
Fri 5/22
6:30 pm-11:15 pm
1 stop7h 45m
San Diego
Tue 5/26
8:00 am-7:58 pm
1 stop8h 58m
$432
MiamiSan Diego
MIA - SAN
MIASAN
Miami
Tue 6/16
7:00 am-12:17 pm
1 stop8h 17m
San Diego
Tue 6/23
7:13 pm-5:42 am
1 stop7h 29m
$440
MiamiSan Diego
MIA - SAN
MIASAN
Miami
Thu 6/4
5:00 pm-11:05 pm
2 stops9h 05m
San Diego
Mon 6/8
10:40 pm-2:25 pm
2 stops12h 45m
$447
Key WestSan Diego
EYW - SAN
EYWSAN
Key West
Thu 4/23
2:40 pm-8:50 pm
1 stop9h 10m
San Diego
Sat 4/25
10:30 pm-10:46 am
1 stop9h 16m
$449
Key WestSan Diego
EYW - SAN
EYWSAN
Key West
Fri 5/8
11:56 am-7:00 pm
1 stop10h 04m
San Diego
Fri 5/15
9:12 am-10:58 pm
2 stops10h 46m
$460
MiamiSan Diego
MIA - SAN
MIASAN
Miami
Wed 6/24
5:10 pm-10:40 pm
2 stops8h 30m
San Diego
Sat 7/11
6:25 am-11:00 pm
2 stops13h 35m
$475
MiamiSan Diego
MIA - SAN
MIASAN
Miami
Fri 7/3
5:35 am-10:55 am
2 stops8h 20m
San Diego
Mon 7/6
10:40 pm-3:50 pm
1 stop14h 10m
$476
MiamiSan Diego
MIA - SAN
MIASAN
Miami
Mon 7/27
4:15 pm-11:05 pm
2 stops9h 50m
San Diego
Sat 8/1
10:40 pm-2:30 pm
1 stop12h 50m
$476
Key WestSan Diego
EYW - SAN
EYWSAN
Key West
Sat 5/9
6:45 am-11:16 am
1 stop7h 31m
San Diego
Fri 5/15
9:12 am-10:58 pm
2 stops10h 46m
$477
Showing 1-10 of 36 resultsSorted by cheapest first
Best time to book a flight from Florida Keys to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Florida Keys with our price prediction graph.
EYW-SAN
MIA-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Florida Keys to San Diego
zzEOA-SAN
EYW-SAN
MIA-SAN
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated April 9, 2026.
See what other customers who have flown with Alaska Airlines,Delta, andUnited Airlines from Florida Keys to San Diego have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Entertainment
7.0
Crew
8.5
Food
7.0
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
Excellentrobert,Feb 2026
LAS - SAN
Overall
7.9
Entertainment
7.0
Crew
8.5
Food
7.0
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
Excellentrobert,Feb 2026
LAS - SAN
Overall
7.9
Entertainment
7.0
Crew
8.5
Food
7.0
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
Excellentrobert,Feb 2026
LAS - SAN
Overall
7.9
Entertainment
7.0
Crew
8.5
Food
7.0
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
Excellentrobert,Feb 2026
LAS - SAN
Overall
7.9
Entertainment
7.0
Crew
8.5
Food
7.0
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
Excellentrobert,Feb 2026
LAS - SAN
Overall
7.9
Entertainment
7.0
Crew
8.5
Food
7.0
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
Excellentrobert,Feb 2026
LAS - SAN
Related info for your journey
Find useful and relevant information for your journey from Florida Keys to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove
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