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San Diego

$132+ Cheap flights from Florida Keys to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/21. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SAN
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Find flight deals from Florida Keys to San Diego

Cheapest flights from Florida Keys to San Diego
Explore the most affordable flight options available from Florida Keys to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/38:22 pmMIA - SAN
Nonstop5h 38mAmerican Airlines
Tue 1/61:27 pmSAN - MIA
Nonstop4h 59mAmerican Airlines
Deal found 11/5$217
This Expedia deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/236:15 amMIA - SAN
1 stop28h 46mFrontier
Mon 12/156:25 amSAN - MIA
1 stop13h 53mFrontier
Deal found 11/5$221
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:05 amMIA - SAN
2 stops15h 10mFrontier
Fri 12/126:34 amSAN - MIA
1 stop19h 45mFrontier
Deal found 11/6$223
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/226:55 amMIA - SAN
1 stop20h 04mMultiple Airlines
Mon 11/248:39 amSAN - MIA
2 stops28h 18mMultiple Airlines
Deal found 11/6$228
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:55 amMIA - SAN
1 stop20h 04mFrontier
Mon 11/248:46 amSAN - MIA
2 stops41h 24mFrontier
Deal found 11/6$229
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/311:49 amMIA - SAN
2 stops13h 57mMultiple Airlines
Sun 1/46:25 amSAN - MIA
1 stop23h 50mMultiple Airlines
Deal found 11/5$230
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:00 amMIA - SAN
1 stop16h 15mFrontier
Mon 12/158:10 pmSAN - MIA
2 stops30h 09mFrontier
Deal found 11/5$231
This Frontier deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/136:00 amMIA - SAN
1 stop12h 52mFrontier
Sun 12/146:25 amSAN - MIA
1 stop13h 34mFrontier
Deal found 11/5$232
This Frontier deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/197:05 amMIA - SAN
1 stop8h 33mFrontier
Sat 1/107:15 amSAN - MIA
1 stop14h 17mFrontier
Deal found 11/6$236
This Trip.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:05 amMIA - SAN
1 stop8h 06mFrontier
Wed 12/311:06 pmSAN - MIA
1 stop13h 29mFrontier
Deal found 11/5$237
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:25 amMIA - SAN
1 stop20h 34mFrontier
Wed 12/106:34 amSAN - MIA
2 stops39h 12mFrontier
Deal found 11/6$238
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:10 pmEYW - SAN
1 stop8h 25mDelta
Wed 12/178:00 amSAN - EYW
1 stop9h 06mDelta
Deal found 11/5$309

Cheap flight deals from Florida Keys to San Diego

Keep the following information in mind while searching for Florida Keys to San Diego flight deals. Data was last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$213
(Kiwi.com)

One-way from

$132
(Kiwi.com)
Provider with most accurate pricing for Key West-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-San Diego flights.
Search Deals
From Florida Keys to San Diego
Search Deals
One-way flight from Florida Keys to San Diego
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Florida Keys to San Diego that are best for you.

Fly from

Florida Keys

Fly to

San Diego

Route

Depart

Return

Price

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 2/6

9:30 am-12:27 pm

Nonstop5h 57m

San Diego

Sun 2/8

1:27 pm-9:26 pm

Nonstop4h 59m

$217

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Tue 3/10

12:00 pm-6:53 pm

1 stop9h 53m

San Diego

Wed 3/11

9:40 pm-10:40 am

1 stop10h 00m

$277

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 12/3

3:50 pm-9:18 pm

1 stop8h 28m

San Diego

Tue 1/6

6:30 am-6:01 pm

1 stop8h 31m

$277

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 1/8

9:15 am-3:57 pm

1 stop9h 42m

San Diego

Sun 1/11

10:25 pm-6:07 am

Nonstop4h 42m

$297

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 1/8

12:00 pm-7:41 pm

1 stop10h 41m

San Diego

Sun 1/11

1:45 pm-5:30 am

2 stops12h 45m

$307

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 12/4

4:10 pm-11:00 pm

1 stop9h 50m

San Diego

Wed 12/10

6:46 am-5:52 pm

1 stop8h 06m

$309

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Fri 12/12

3:02 pm-9:18 pm

1 stop9h 16m

San Diego

Tue 12/16

6:15 am-5:15 pm

1 stop8h 00m

$309

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 12/11

3:02 pm-9:18 pm

1 stop9h 16m

San Diego

Tue 12/16

6:15 am-5:15 pm

1 stop8h 00m

$309

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 12/4

12:38 pm-6:18 pm

1 stop8h 40m

San Diego

Wed 12/10

8:00 am-8:06 pm

1 stop9h 06m

$309

Key WestSan Diego

EYW - SAN

EYWSAN

Key West

Thu 12/11

3:02 pm-9:18 pm

1 stop9h 16m

San Diego

Wed 12/17

8:00 am-8:06 pm

1 stop9h 06m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/6

Showing 1-10 of 31 results
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Best time to book a flight from Florida Keys to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to San Diego

What is the cheapest time of day to fly from EOA to SAN?

Find hourly flight availability from Florida Keys to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 38% on flights from Florida Keys to San Diego by exploring options for tickets in the evening.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated November 6, 2025.
See what other customers who have flown with Alaska Airlines, Delta, and United Airlines from Florida Keys to San Diego have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
11,246 reviews

Food

7.1

Comfort

7.8

Boarding

8.1

Overall

8.0

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Alaska Airlines
8.0
Very good
11,246 reviews
Alaska Airlines
8.0
Very good
11,246 reviews

Food

7.1

Comfort

7.8

Boarding

8.1

Overall

8.0

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Delta
7.9
Good
8,001 reviews
Alaska Airlines
8.0
Very good
11,246 reviews

Food

7.1

Comfort

7.8

Boarding

8.1

Overall

8.0

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
United Airlines
7.4
Good
9,007 reviews
Alaska Airlines
8.0
Very good
11,246 reviews

Food

7.1

Comfort

7.8

Boarding

8.1

Overall

8.0

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
American Airlines
7.2
Good
11,040 reviews
Alaska Airlines
8.0
Very good
11,246 reviews

Food

7.1

Comfort

7.8

Boarding

8.1

Overall

8.0

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Frontier
5.8
Fair
3,116 reviews
Alaska Airlines
8.0
Very good
11,246 reviews

Food

7.1

Comfort

7.8

Boarding

8.1

Overall

8.0

Crew

8.5

Entertainment

7.0

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Florida Keys?

    San Diego (SAN), located 2.6 mi from the city center, is the airport you fly into when you book flights from Florida Keys to San Diego.

  • How long is the flight from Florida Keys to San Diego?

    For as low as $217, American Airlines can have you in San Diego from Florida Keys in 5h 57m. Florida Keys and San Diego are separated by a distance of 2262 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Florida Keys to San Diego that include hotel bookings?

    Yes. In addition to deals on Florida Keys to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to San Diego.

  • Can I find deals for business class flights from Florida Keys to San Diego?

    Yes. Cheapflights offers flight deals from Florida Keys to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
La Mesa
Poway
Lemon Grove
National City

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