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$109+ Cheap flights from Florida Keys to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SAN
Aug 27 — Sep 31
Wed 8/27
Wed 9/3
1 adult, Economy
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Cheap flight deals from Florida Keys to San Diego

Keep the following information in mind while searching for Florida Keys to San Diego flight deals. Data was last updated August 22, 2025.

Round-trip from

$205
(Booking.com)

One-way from

$109
(Cheapflightsfares)
From Florida Keys to San Diego
Search Deals
One-way flight from Florida Keys to San Diego
Search Deals

Find flight deals from Florida Keys to San Diego

Cheapest flights from Florida Keys to San Diego
Explore the most affordable flight options available from Florida Keys to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 22, 2025.

This Booking.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/36:00 amMIA - SAN
1 stop20h 53mFrontier
Sun 10/1212:46 pmSAN - MIA
1 stop7h 56mFrontier
Deal found 8/19$205
This FlightHub deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/287:23 pmMIA - SAN
1 stop15h 06mMultiple Airlines
Sun 10/55:37 pmSAN - MIA
1 stop22h 20mMultiple Airlines
Deal found 8/19$207
This Frontier deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:05 amMIA - SAN
2 stops14h 35mFrontier
Sun 11/165:47 pmSAN - MIA
1 stop9h 32mFrontier
Deal found 8/18$208
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/249:30 pmMIA - SAN
1 stop12h 56mMultiple Airlines
Sat 11/16:41 amSAN - MIA
1 stop20h 38mMultiple Airlines
Deal found 8/19$209
This Mytrip deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/156:00 amMIA - SAN
1 stop8h 09mFrontier
Sun 9/216:35 amSAN - MIA
1 stop15h 09mFrontier
Deal found 8/20$210
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/237:13 pmMIA - SAN
2 stops17h 44mMultiple Airlines
Sun 10/2612:46 pmSAN - MIA
1 stop7h 56mMultiple Airlines
Deal found 8/19$211
This FlightHub deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/126:00 amMIA - SAN
1 stop8h 09mMultiple Airlines
Tue 9/167:47 pmSAN - MIA
1 stop20h 08mMultiple Airlines
Deal found 8/19$212
This FlightHub deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/77:23 pmMIA - SAN
1 stop15h 06mMultiple Airlines
Sun 9/143:55 pmSAN - MIA
1 stop28h 05mMultiple Airlines
Deal found 8/19$213
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/276:45 amMIA - SAN
1 stop18h 39mMultiple Airlines
Wed 10/17:47 pmSAN - MIA
2 stops25h 57mMultiple Airlines
Deal found 8/18$214
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/196:00 amMIA - SAN
1 stop8h 09mMultiple Airlines
Mon 9/297:47 pmSAN - MIA
2 stops19h 17mMultiple Airlines
Deal found 8/19$215
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/196:00 amMIA - SAN
1 stop8h 09mFrontier
Sun 9/219:03 pmSAN - MIA
2 stops18h 54mFrontier
Deal found 8/19$216
This Mytrip deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/146:00 amMIA - SAN
1 stop8h 09mFrontier
Sat 9/207:15 amSAN - MIA
1 stop14h 29mFrontier
Deal found 8/21$217

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 22, 2025.
Use the filters below to find and compare flights from Florida Keys to San Diego that are best for you.

Fly from

Florida Keys

Fly to

San Diego

Route

Depart

Return

Price

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 10/3

6:00 am-11:53 pm

1 stop20h 53m

San Diego

Sun 10/12

12:46 pm-11:42 pm

1 stop7h 56m

$205

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 11/6

5:05 am-6:09 pm

2 stops16h 04m

San Diego

Sat 11/8

7:18 pm-6:19 am

1 stop8h 01m

$205

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sun 9/28

7:23 pm-7:29 am

1 stop15h 06m

San Diego

Sun 10/5

5:37 pm-6:57 pm

1 stop22h 20m

$207

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 11/7

5:05 am-4:40 pm

2 stops14h 35m

San Diego

Sun 11/16

5:47 pm-6:19 am

1 stop9h 32m

$208

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sun 11/9

7:30 am-3:14 pm

1 stop10h 44m

San Diego

Sun 11/9

5:47 pm-10:11 am

2 stops13h 24m

$208

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 10/24

9:30 pm-7:26 am

1 stop12h 56m

San Diego

Sat 11/1

6:41 am-6:19 am

1 stop20h 38m

$209

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Mon 9/15

6:00 am-11:09 am

1 stop8h 09m

San Diego

Sun 9/21

6:35 am-12:44 am

1 stop15h 09m

$210

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 9/19

8:48 pm-6:42 pm

2 stops24h 54m

San Diego

Sun 9/28

6:35 am-12:44 am

1 stop15h 09m

$210

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 9/17

7:20 pm-7:29 am

1 stop15h 09m

San Diego

Wed 9/24

1:35 pm-6:04 pm

2 stops25h 29m

$210

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 10/23

7:13 pm-9:57 am

2 stops17h 44m

San Diego

Sun 10/26

12:46 pm-11:42 pm

1 stop7h 56m

$211

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/19

Showing 1-10 of 26 results
1
2
3

Best time to book a flight from Florida Keys to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to San Diego

What is the cheapest time of day to fly from EOA to SAN?

Find hourly flight availability from Florida Keys to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 22, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida Keys to San Diego as you normally would.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated August 22, 2025.
See what other customers who have flown with Alaska Airlines, Delta, and American Airlines from Florida Keys to San Diego have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Overall

8.0

Crew

8.5

Entertainment

7.0

Food

7.1

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Aug 2025

PDX - SJC

They had no snacks and had to pay for the Wifi.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Overall

8.0

Crew

8.5

Entertainment

7.0

Food

7.1

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Aug 2025

PDX - SJC

They had no snacks and had to pay for the Wifi.
Delta
8.0
Very good
7,981 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Overall

8.0

Crew

8.5

Entertainment

7.0

Food

7.1

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Aug 2025

PDX - SJC

They had no snacks and had to pay for the Wifi.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Overall

8.0

Crew

8.5

Entertainment

7.0

Food

7.1

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Aug 2025

PDX - SJC

They had no snacks and had to pay for the Wifi.
Spirit Airlines
6.3
Okay
8,029 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Overall

8.0

Crew

8.5

Entertainment

7.0

Food

7.1

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Aug 2025

PDX - SJC

They had no snacks and had to pay for the Wifi.
Frontier
5.8
Fair
3,207 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Overall

8.0

Crew

8.5

Entertainment

7.0

Food

7.1

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,Aug 2025

PDX - SJC

They had no snacks and had to pay for the Wifi.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Florida Keys?

    San Diego (SAN), located 2.6 mi from the city center, is the airport you fly into when you book flights from Florida Keys to San Diego.

  • How long is the flight from Florida Keys to San Diego?

    For as low as $422, Frontier can have you in San Diego from Florida Keys in 14h 11m. Florida Keys and San Diego are separated by a distance of 2209 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Florida Keys to San Diego that include hotel bookings?

    Yes. In addition to deals on Florida Keys to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to San Diego.

  • Can I find deals for business class flights from Florida Keys to San Diego?

    Yes. Cheapflights offers flight deals from Florida Keys to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Florida Keys to San Diego (average of $286). Flying from Florida Keys to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
La Mesa
Poway
Lemon Grove
Coronado
Imperial Beach
National City
Alpine

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Florida Keys to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Florida Keys to San Diego

Discover the top airline that operate flights from Florida Keys to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$299Average$468FlexibilityNo cancel feeOn-time71%

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