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San Diego

$133+ Cheap flights from Florida Keys to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/4. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SAN
Jan 22 — Jan 291
Thu 1/22
Thu 1/29
1 adult, Economy
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Cheap flight deals from Florida Keys to San Diego

Cheapest flights from Florida Keys to San Diego
Explore the most affordable flight options available from Florida Keys to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

This Priceline deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:30 pmMIA - SAN
1 stop8h 35mFrontier
Tue 1/67:00 amSAN - MIA
1 stop7h 19mFrontier
Deal found 12/20$231
This Booking.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:30 pmMIA - SAN
1 stop8h 35mFrontier
Wed 1/73:29 pmSAN - MIA
1 stop17h 28mFrontier
Deal found 12/20$238
This Kiwi.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:00 amMIA - SAN
2 stops29h 57mMultiple Airlines
Tue 1/63:29 pmSAN - MIA
1 stop22h 04mMultiple Airlines
Deal found 12/20$308
This Delta deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:43 pmMIA - SAN
1 stop9h 20mDelta
Mon 1/127:35 pmSAN - MIA
1 stop8h 10mDelta
Deal found 12/22$312
This Frontier deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/264:01 pmMIA - SAN
1 stop9h 59mFrontier
Tue 1/67:00 amSAN - MIA
1 stop7h 19mFrontier
Deal found 12/21$313
This eDestinos deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:05 amMIA - SAN
1 stop20h 54mFrontier
Mon 1/54:47 pmSAN - MIA
1 stop9h 13mFrontier
Deal found 12/20$314
This Kiwi.com deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:30 pmMIA - SAN
2 stops22h 41mFrontier
Mon 1/126:25 amSAN - MIA
1 stop15h 48mFrontier
Deal found 12/22$324
This Kiwi.com deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:30 pmMIA - SAN
2 stops22h 41mFrontier
Tue 1/1312:00 pmSAN - MIA
1 stop14h 48mFrontier
Deal found 12/22$330
This Frontier deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/287:05 amMIA - SAN
1 stop8h 06mFrontier
Mon 1/57:21 pmSAN - MIA
1 stop7h 14mFrontier
Deal found 12/21$333
This Kiwi.com deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/314:30 pmMIA - SAN
2 stops22h 41mFrontier
Thu 1/86:25 amSAN - MIA
1 stop15h 48mFrontier
Deal found 12/22$337
This Kiwi.com deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:10 amMIA - SAN
2 stops29h 47mFrontier
Mon 1/126:25 amSAN - MIA
1 stop15h 48mFrontier
Deal found 12/22$341
This Frontier deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:05 amMIA - SAN
1 stop8h 06mFrontier
Tue 1/67:00 amSAN - MIA
1 stop7h 19mFrontier
Deal found 12/21$343

Find flight deals from Florida Keys to San Diego

Keep the following information in mind while searching for Florida Keys to San Diego flight deals. Data was last updated December 23, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$219
(eDestinos)

One-way from

$133
(Delta)
Provider with most accurate pricing for Key West-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-San Diego flights.
Search Deals
From Florida Keys to San Diego
Search Deals
One-way flight from Florida Keys to San Diego
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Florida Keys to San Diego that are best for you.

Fly from

Florida Keys

Fly to

San Diego

Route

Depart

Return

Price

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 1/30

6:55 am-1:20 pm

2 stops9h 25m

San Diego

Mon 2/2

6:20 am-4:30 pm

1 stop7h 10m

$222

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 2/18

3:20 pm-8:37 pm

1 stop8h 17m

San Diego

Tue 3/3

6:30 am-6:21 pm

1 stop8h 51m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 2/27

6:15 am-1:47 pm

1 stop10h 32m

San Diego

Sun 3/1

8:00 am-6:16 pm

1 stop7h 16m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 1/30

9:00 am-3:33 pm

1 stop9h 33m

San Diego

Tue 2/3

12:11 pm-9:54 pm

1 stop6h 43m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 2/25

3:20 pm-8:37 pm

1 stop8h 17m

San Diego

Sat 2/28

10:30 pm-10:40 am

1 stop9h 10m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 2/4

11:10 am-4:36 pm

1 stop8h 26m

San Diego

Mon 2/9

12:11 pm-9:54 pm

1 stop6h 43m

$257

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Wed 1/28

6:55 am-1:20 pm

2 stops9h 25m

San Diego

Sat 1/31

7:25 am-4:25 pm

1 stop6h 00m

$282

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Fri 1/23

12:00 pm-6:40 pm

2 stops9h 40m

San Diego

Tue 1/27

10:10 am-10:00 pm

2 stops8h 50m

$287

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Sun 2/1

7:50 am-1:48 pm

1 stop8h 58m

San Diego

Sat 2/7

6:35 am-5:55 pm

1 stop8h 20m

$297

MiamiSan Diego

MIA - SAN

MIASAN

Miami

Thu 1/15

7:50 am-3:00 pm

2 stops10h 10m

San Diego

Wed 1/21

10:05 am-9:30 pm

1 stop8h 25m

$299

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/21

Showing 1-10 of 31 results
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Best time to book a flight from Florida Keys to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to San Diego

What is the cheapest time of day to fly from EOA to SAN?

Find hourly flight availability from Florida Keys to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 23, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 38% on flights from Florida Keys to San Diego by exploring options for tickets in the evening.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated December 23, 2025.
See what other customers who have flown with Alaska Airlines, Delta, and United Airlines from Florida Keys to San Diego have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
11,513 reviews

Boarding

8.1

Entertainment

7.0

Crew

8.5

Food

7.1

Overall

8.0

Comfort

7.8

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Alaska Airlines
8.0
Very good
11,513 reviews
Alaska Airlines
8.0
Very good
11,513 reviews

Boarding

8.1

Entertainment

7.0

Crew

8.5

Food

7.1

Overall

8.0

Comfort

7.8

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Delta
7.9
Good
8,014 reviews
Alaska Airlines
8.0
Very good
11,513 reviews

Boarding

8.1

Entertainment

7.0

Crew

8.5

Food

7.1

Overall

8.0

Comfort

7.8

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
United Airlines
7.4
Good
9,106 reviews
Alaska Airlines
8.0
Very good
11,513 reviews

Boarding

8.1

Entertainment

7.0

Crew

8.5

Food

7.1

Overall

8.0

Comfort

7.8

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
American Airlines
7.2
Good
11,054 reviews
Alaska Airlines
8.0
Very good
11,513 reviews

Boarding

8.1

Entertainment

7.0

Crew

8.5

Food

7.1

Overall

8.0

Comfort

7.8

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.
Frontier
5.8
Fair
3,075 reviews
Alaska Airlines
8.0
Very good
11,513 reviews

Boarding

8.1

Entertainment

7.0

Crew

8.5

Food

7.1

Overall

8.0

Comfort

7.8

Reviews

1 / 20
6.0
Good

Hannah,Aug 2025

SFO - SAN

Ticket said TSA pre check, but then the TSA agent said that Alaska Airlines has not actually entered the pre check information for the ticket, so I had to use regular security. During boarding, I have a disability and need to board early. The Alaska Airlines employee announced disability boarding, but then immediately announced 2 other groups to board, so I still had to fight the crowds. On the plane, the stewardess was brusk and rude. Seats were very uncomfortable, especially on lower back.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Florida Keys?

    San Diego (SAN), located 2.6 mi from the city center, is the airport you fly into when you book flights from Florida Keys to San Diego.

  • How long is the flight from Florida Keys to San Diego?

    For as low as $257, Southwest can have you in San Diego from Florida Keys in 8h 17m. Florida Keys and San Diego are separated by a distance of 2262 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Florida Keys to San Diego one-way?

    The cheapest airlines for a one-way flight from Florida Keys to San Diego are Spirit Airlines ($75), Frontier ($80), and United Airlines ($93).

  • Can I find deals for flights from Florida Keys to San Diego that include hotel bookings?

    Yes. In addition to deals on Florida Keys to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to San Diego.

  • Can I find deals for business class flights from Florida Keys to San Diego?

    Yes. Cheapflights offers flight deals from Florida Keys to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

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