$297+ Cheap flights from Key West to San Diego (EYW - SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — SAN
Dec 9 — Dec 161
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Key West to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Key West to San Diego
Cheapest
Best
Last-minute
One-way
Cheapest flights from Key West to San DiegoExplore the most affordable flight options available from Key West to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 9, 2026.
Explore the most affordable flight options available from Key West to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 9, 2026.
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:06 pm -
1 stop8h 32m
Sat 12/126:20 am -
1 stop7h 50m
Deal found 11/4![Delta logo]()
$479
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:59 pm -
2 stops49h 53m
Tue 11/241:22 pm -
1 stop25h 30m
Deal found 11/5![Breeze Airways logo]()
$589
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/811:26 am -
2 stops10h 41m
Sat 12/1210:42 pm -
1 stop8h 02m
Deal found 11/5![American Airlines logo]()
$611
This American Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/232:45 pm -
1 stop7h 26m
Sat 1/210:45 pm -
1 stop8h 00m
Deal found 11/7![American Airlines logo]()
$681
Best flights from Key West to San DiegoDiscover carefully curated flight deals from Key West to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 9, 2026.
Discover carefully curated flight deals from Key West to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 9, 2026.
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:06 pm -
1 stop8h 32m
Sat 12/126:20 am -
1 stop7h 50m
Deal found 11/4![Delta logo]()
$479
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/810:14 am -
2 stops11h 53m
Sat 12/1210:42 pm -
1 stop8h 02m
Deal found 11/4![American Airlines logo]()
$659
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/235:52 pm -
2 stops29h 48m
Sat 1/24:45 pm -
2 stops15h 56m
Deal found 11/6![United Airlines logo]()
$824
This American Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/232:45 pm -
1 stop7h 26m
Sat 1/210:45 pm -
1 stop8h 00m
Deal found 11/7![American Airlines logo]()
$681
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:08 pm -
1 stop8h 24m
Tue 11/248:00 am -
1 stop9h 00m
Deal found 11/5![Delta logo]()
$777
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:30 am -
2 stops10h 55m
Tue 11/246:15 am -
2 stops9h 38m
Deal found 11/5![American Airlines logo]()
$874
Last-minute flights from Key West to San DiegoDiscover last-minute flight deals from Key West to San Diego. Data last updated November 9, 2026 and is based on user searches.
Discover last-minute flight deals from Key West to San Diego. Data last updated November 9, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:59 pm -
2 stops49h 53m
Tue 11/241:22 pm -
1 stop25h 30m
Deal found 11/5![Breeze Airways logo]()
$589
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:06 pm -
1 stop8h 32m
Sat 12/126:20 am -
1 stop7h 50m
Deal found 11/4![Delta logo]()
$479
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/811:26 am -
2 stops10h 41m
Sat 12/1210:42 pm -
1 stop8h 02m
Deal found 11/5![American Airlines logo]()
$611
This American Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/232:45 pm -
1 stop7h 26m
Sat 1/210:45 pm -
1 stop8h 00m
Deal found 11/7![American Airlines logo]()
$681
One-way flights from Key West to San DiegoSearch for one-way flight options from Key West to San Diego. Find affordable one-way fares based on user searches. Data last updated November 9, 2026.
Search for one-way flight options from Key West to San Diego. Find affordable one-way fares based on user searches. Data last updated November 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2510:59 am -
3 stops58h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Multiple Airlines logo]()
$297
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/34:10 pm -
1 stop9h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![United Airlines logo]()
$469
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/310:14 am -
2 stops10h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![American Airlines logo]()
$498
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/155:05 pm -
1 stop9h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![American Airlines logo]()
$1,791
Find flight deals from Key West to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Key West (EYW) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $479 (Delta) |
One-way from | $297 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Key West to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 9, 2026.
Use the filters below to find and compare flights from Key West to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Key WestSan Diego
EYW Key West - SAN San Diego
EYWSAN
Key West
Fri 12/25
10:59 am-6:58 pm
3 stops58h 59m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$297
Quickest round-trip
Key WestSan Diego
EYW Key West - SAN San Diego
EYWSAN
Key West
Thu 12/3
4:10 pm-10:33 pm
1 stop9h 23m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$469
Key WestSan Diego
EYW Key West - SAN San Diego
EYWSAN
Key West
Tue 12/8
6:06 pm-11:38 pm
1 stop8h 32m
San Diego
Sat 12/12
6:20 am-5:10 pm
1 stop7h 50m
$479
Key WestSan Diego
EYW Key West - SAN San Diego
EYWSAN
Key West
Thu 12/3
10:14 am-5:55 pm
2 stops10h 41m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$498
Key WestSan Diego
EYW Key West - SAN San Diego
EYWSAN
Key West
Tue 12/8
10:14 am-7:07 pm
2 stops11h 53m
San Diego
Sat 12/12
10:42 pm-9:44 am
1 stop8h 02m
$659
Key WestSan Diego
EYW Key West - SAN San Diego
EYWSAN
Key West
Wed 12/23
2:45 pm-7:11 pm
1 stop7h 26m
San Diego
Sat 1/2
10:45 pm-9:45 am
1 stop8h 00m
$681
Key WestSan Diego
EYW Key West - SAN San Diego
EYWSAN
Key West
Fri 11/20
6:08 pm-11:32 pm
1 stop8h 24m
San Diego
Tue 11/24
8:00 am-8:00 pm
1 stop9h 00m
$777
Key WestSan Diego
EYW Key West - SAN San Diego
EYWSAN
Key West
Wed 12/23
5:52 pm-8:40 pm
2 stops29h 48m
San Diego
Sat 1/2
4:45 pm-11:41 am
2 stops15h 56m
$824
Key WestSan Diego
EYW Key West - SAN San Diego
EYWSAN
Key West
Fri 11/20
6:30 am-2:25 pm
2 stops10h 55m
San Diego
Tue 11/24
6:15 am-6:53 pm
2 stops9h 38m
$874
Key WestSan Diego
EYW Key West - SAN San Diego
EYWSAN
Key West
Sun 11/15
4:44 pm-11:56 pm
2 stops10h 12m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$2,235
Sorted by cheapest first
Compare providers for flights from Key West to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Key West to San Diego in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Key West-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Key West-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Key West-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Key West-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Key West-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Key West to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Key West with our price prediction graph.
EYW-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Key West to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
San Ysidro
Poway
Coronado
La Mesa
Julian
Santee
Lemon Grove
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Key West
Popular flights
San Diego flight routes