How long is the flight from Missouri to Roanoke?

There are many flights that can get you from Missouri to Roanoke in 4h 07m. Fly via United Airlines, Delta, or American Airlines to get the fastest option. The distance between Missouri and Roanoke is about 574 mi. This flight may include one or multiple stops.

In terms of precipitation, rainfall in Roanoke ranges from 2.9 - 4.1 inches per month. May is typically the wettest month, when rainfall can reach 4.1 in. January is typically the driest time to visit Roanoke when rainfall is around 2.9 in.

If weather is an important factor for your trip to Roanoke, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 37.4 F).

What are the most popular routes from Missouri to Roanoke?

Most travelers choose Lambert-St Louis - Roanoke, Kansas City - Roanoke or Columbia Regional - Roanoke when deciding on the best route from Missouri to Roanoke.

What are the most popular airlines that fly from Missouri to Roanoke?

The most popular airlines flying from Missouri to Roanoke are American Airlines, Delta and United Airlines. Something to consider prior to booking your flight.

What airport do you fly into for flights to Roanoke from Missouri?

Roanoke (ROA), located 4.2 mi from the city center, is the airport you fly into when you book flights from Missouri to Roanoke.

Can I find deals for flights from Missouri to Roanoke that include hotel bookings?

Yes. In addition to deals on Missouri to Roanoke flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Missouri to Roanoke?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Roanoke.

Can I find deals for business class flights from Missouri to Roanoke?

Yes. Cheapflights offers flight deals from Missouri to Roanoke by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$200+ Flights from Missouri to Roanoke

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Cheap flight deals from Missouri to Roanoke

Cheapest flights from Missouri to Roanoke
Explore the most affordable flight options available from Missouri to Roanoke. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 21, 2025.

Thu 12/251:22 pmSTL - ROA

1 stop5h 04mDelta

Sat 12/277:03 pmROA - STL

1 stop5h 39mDelta

Deal found 12/21

$353

Tue 12/238:15 amSTL - ROA

1 stop5h 01mUnited Airlines

Sun 12/285:42 pmROA - STL

1 stop5h 01mUnited Airlines

Deal found 12/21

$424

Thu 12/256:02 amSTL - ROA

2 stops10h 30mAmerican Airlines

Sat 12/2710:57 amROA - STL

1 stop13h 59mAmerican Airlines

Deal found 12/21

$653

Best flights from Missouri to Roanoke
Discover carefully curated flight deals from Missouri to Roanoke that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 21, 2025.

Sat 1/2411:17 amCOU - ROA

1 stop4h 46mUnited Airlines

Tue 1/276:45 amROA - COU

1 stop4h 57mUnited Airlines

Deal found 12/20

$328

Mon 1/196:57 pmSTL - ROA

1 stop4h 07mDelta

Mon 1/267:05 amROA - STL

1 stop6h 28mDelta

Deal found 12/20

$354

Thu 6/46:31 amSTL - ROA

1 stop4h 20mAmerican Airlines

Sun 6/78:28 pmROA - STL

1 stop3h 58mAmerican Airlines

Deal found 12/19

$390

Tue 2/108:09 amCOU - ROA

1 stop5h 37mUnited Airlines

Wed 2/1810:43 amROA - COU

1 stop4h 45mUnited Airlines

Deal found 12/20

$328

Wed 2/118:09 amCOU - ROA

1 stop5h 37mUnited Airlines

Wed 2/1810:43 amROA - COU

1 stop4h 45mUnited Airlines

Deal found 12/20

$328

Fri 1/166:23 pmMCI - ROA

1 stop4h 41mDelta

Sun 1/186:00 amROA - MCI

1 stop7h 44mDelta

Deal found 12/21

$374

Tue 2/108:09 amCOU - ROA

2 stops10h 22mUnited Airlines

Sat 2/1410:43 amROA - COU

1 stop4h 45mUnited Airlines

Deal found 12/20

$334

Fri 1/167:00 amSTL - ROA

1 stop8h 10mAmerican Airlines

Fri 1/234:40 pmROA - STL

2 stops7h 32mAmerican Airlines

Deal found 12/19

$412

Sat 1/175:00 pmSTL - ROA

1 stop6h 04mDelta

Sat 1/243:47 pmROA - STL

1 stop4h 40mDelta

Deal found 12/19

$404

Tue 1/138:09 amCOU - ROA

1 stop5h 37mUnited Airlines

Sat 1/1710:15 amROA - COU

2 stops8h 04mUnited Airlines

Deal found 12/19

$334

Wed 1/216:30 amSTL - ROA

1 stop4h 27mUnited Airlines

Sat 1/245:39 pmROA - STL

1 stop4h 34mUnited Airlines

Deal found 12/18

$339

Mon 1/197:00 amSTL - ROA

1 stop8h 10mAmerican Airlines

Mon 1/264:40 pmROA - STL

2 stops7h 32mAmerican Airlines

Deal found 12/20

$487

Wed 1/283:24 pmMCI - ROA

1 stop4h 47mUnited Airlines

Sat 1/3112:40 pmROA - MCI

1 stop6h 01mUnited Airlines

Deal found 12/19

$339

Tue 2/108:09 amCOU - ROA

1 stop5h 37mUnited Airlines

Thu 2/196:40 amROA - COU

1 stop4h 53mUnited Airlines

Deal found 12/20

$363

Tue 2/108:09 amCOU - ROA

2 stops10h 22mUnited Airlines

Sun 2/156:40 amROA - COU

1 stop4h 53mUnited Airlines

Deal found 12/20

$369

Thu 2/265:30 amMCI - ROA

2 stops7h 57mAmerican Airlines

Sun 3/12:52 pmROA - MCI

2 stops10h 15mAmerican Airlines

Deal found 12/20

$602

Thu 2/268:00 amMCI - ROA

2 stops11h 07mUnited Airlines

Sun 3/110:15 amROA - MCI

1 stop5h 49mUnited Airlines

Deal found 12/20

$400

Fri 1/168:00 amMCI - ROA

1 stop5h 46mUnited Airlines

Sun 1/186:45 amROA - MCI

2 stops10h 23mUnited Airlines

Deal found 12/21

$445

Last-minute flights from Missouri to Roanoke
Discover last-minute flight deals from Missouri to Roanoke. Data last updated December 21, 2025 and is based on user searches.

Fri 1/96:55 pmSTL - ROA

1 stop4h 09mDelta

Sun 1/116:00 amROA - STL

1 stop6h 05mDelta

Deal found 12/20

$299

Fri 1/912:44 pmSTL - ROA

1 stop5h 47mUnited Airlines

Sun 1/116:45 amROA - STL

1 stop5h 17mUnited Airlines

Deal found 12/20

$370

Tue 1/138:09 amCOU - ROA

2 stops10h 22mUnited Airlines

Sat 1/1710:15 amROA - COU

2 stops8h 04mUnited Airlines

Deal found 12/19

$374

Fri 1/166:55 pmSTL - ROA

1 stop4h 09mDelta

Fri 1/237:05 amROA - STL

1 stop6h 28mDelta

Deal found 12/19

$354

Fri 1/166:23 pmMCI - ROA

1 stop4h 41mDelta

Sun 1/186:00 amROA - MCI

1 stop7h 44mDelta

Deal found 12/21

$374

Fri 1/167:00 amSTL - ROA

1 stop8h 10mAmerican Airlines

Fri 1/234:40 pmROA - STL

2 stops7h 32mAmerican Airlines

Deal found 12/19

$412

Fri 1/168:00 amMCI - ROA

1 stop5h 46mUnited Airlines

Sun 1/186:45 amROA - MCI

2 stops10h 23mUnited Airlines

Deal found 12/21

$445

Sat 1/175:00 pmSTL - ROA

1 stop6h 04mDelta

Sat 1/243:47 pmROA - STL

1 stop4h 40mDelta

Deal found 12/19

$404

Mon 1/197:00 amSTL - ROA

1 stop8h 10mAmerican Airlines

Mon 1/264:40 pmROA - STL

2 stops7h 32mAmerican Airlines

Deal found 12/20

$487

Wed 1/218:05 amSTL - ROA

1 stop5h 41mUnited Airlines

Sat 1/2412:40 pmROA - STL

1 stop4h 23mUnited Airlines

Deal found 12/20

$339

Sat 1/2411:17 amCOU - ROA

1 stop4h 46mUnited Airlines

Tue 1/276:45 amROA - COU

1 stop4h 57mUnited Airlines

Deal found 12/21

$328

Wed 1/288:00 amMCI - ROA

1 stop5h 46mUnited Airlines

Sat 1/316:45 amROA - MCI

1 stop4h 47mUnited Airlines

Deal found 12/20

$339

One-way flights from Missouri to Roanoke
Search for one-way flight options from Missouri to Roanoke. Find affordable one-way fares based on user searches. Data last updated December 21, 2025.

Sat 1/178:32 pmSTL - ROA

3 stops34h 40mMultiple Airlines

Deal found 12/19

$200

Tue 1/206:23 amMCI - ROA

1 stop7h 42mAmerican Airlines

Deal found 12/19

$249

Sat 1/175:00 pmSTL - ROA

1 stop6h 04mDelta

Deal found 12/19

$270

Tue 1/205:04 pmMCI - ROA

3 stops44h 51mMultiple Airlines

Deal found 12/19

$273

Tue 1/65:11 pmSTL - ROA

3 stops44h 44mMultiple Airlines

Deal found 12/19

$299

Tue 1/65:00 pmSTL - ROA

1 stop6h 04mDelta

Deal found 12/19

$332

Fri 1/94:00 pmMCI - ROA

1 stop7h 04mDelta

Deal found 12/20

$332

Fri 1/95:45 amMCI - ROA

2 stops12h 46mUnited Airlines

Deal found 12/20

$337

Sat 12/274:53 pmSTL - ROA

1 stop6h 13mAmerican Airlines

Deal found 12/20

$365

Fri 1/26:35 pmSTL - ROA

1 stop4h 04mAmerican Airlines

Deal found 12/20

$390

Sat 1/176:30 amSTL - ROA

2 stops12h 01mUnited Airlines

Deal found 12/19

$430

Sun 1/411:51 amSTL - ROA

3 stops31h 49mMultiple Airlines

Deal found 12/20

$451

Find flight deals from Missouri to Roanoke

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$294 (American Airlines)
One-way from	$200 (Kiwi.com)
Popular in	November
Cheapest in	January
Average price	$259

Provider with most accurate pricing for Lambert-St Louis-Roanoke flight deals.

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Provider most trusted by Cheapflights users for Lambert-St Louis-Roanoke flights.

Search Deals

From Missouri to Roanoke

Search Deals

One-way flight from Missouri to Roanoke

Search Deals

Highest demand for flights based on searches. 18% potential increase in price ($79 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 9% potential price decrease ($32 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Fly from

Fly to

Route

Depart

Return

Price

ColumbiaRoanoke

COU - ROA

COUROA

Columbia Regional

Sat 1/24

11:17 am-5:03 pm

1 stop4h 46m

Roanoke

Tue 1/27

6:45 am-10:42 am

1 stop4h 57m

$328

ColumbiaRoanoke

COU - ROA

COUROA

Columbia Regional

Tue 2/10

8:09 am-2:46 pm

1 stop5h 37m

Roanoke

Wed 2/18

10:43 am-2:28 pm

1 stop4h 45m

$328

ColumbiaRoanoke

COU - ROA

COUROA

Columbia Regional

Wed 2/11

8:09 am-2:46 pm

1 stop5h 37m

Roanoke

Wed 2/18

10:43 am-2:28 pm

1 stop4h 45m

$328

ColumbiaRoanoke

COU - ROA

COUROA

Columbia Regional

Tue 2/10

8:09 am-7:31 pm

2 stops10h 22m

Roanoke

Sat 2/14

10:43 am-2:28 pm

1 stop4h 45m

$334

ColumbiaRoanoke

COU - ROA

COUROA

Columbia Regional

Tue 1/13

8:09 am-2:46 pm

1 stop5h 37m

Roanoke

Sat 1/17

10:15 am-5:19 pm

2 stops8h 04m

$334

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Wed 1/21

6:30 am-11:57 am

1 stop4h 27m

Roanoke

Sat 1/24

5:39 pm-9:13 pm

1 stop4h 34m

$339

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

Wed 1/28

3:24 pm-9:11 pm

1 stop4h 47m

Roanoke

Sat 1/31

12:40 pm-5:41 pm

1 stop6h 01m

$339

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Mon 1/19

6:57 pm-12:04 am

1 stop4h 07m

Roanoke

Mon 1/26

7:05 am-12:33 pm

1 stop6h 28m

$354

ColumbiaRoanoke

COU - ROA

COUROA

Columbia Regional

Tue 2/10

8:09 am-2:46 pm

1 stop5h 37m

Roanoke

Thu 2/19

6:40 am-10:33 am

1 stop4h 53m

$363

ColumbiaRoanoke

COU - ROA

COUROA

Columbia Regional

Tue 2/10

8:09 am-7:31 pm

2 stops10h 22m

Roanoke

Sun 2/15

6:40 am-10:33 am

1 stop4h 53m

$369

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/19

Showing 1-10 of 31 results

Best time to book a flight from Missouri to Roanoke

Have a flexible travel schedule? Discover the best time to fly to Roanoke from Missouri with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Roanoke

What is the cheapest month to book a flight from Missouri to Roanoke?

Currently, May is the cheapest month in which you can book a flight from Missouri to Roanoke (average of $210). Flying from Missouri to Roanoke in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to ROA?

A simple way to save on the total cost of your ticket is to fly from Missouri to Roanoke in the afternoon. If you’re flexible enough to do this you can expect to save up to 27% on your trip compared to booking a flight in the morning.

Related info for your journey

What airport do you fly into for flights to Roanoke from Missouri?
Roanoke (ROA), located 4.2 mi from the city center, is the airport you fly into when you book flights from Missouri to Roanoke.
How long is the flight from Missouri to Roanoke?
There are many flights that can get you from Missouri to Roanoke in 4h 07m. Fly via United Airlines, Delta, or American Airlines to get the fastest option. The distance between Missouri and Roanoke is about 574 mi. This flight may include one or multiple stops.
What are the most popular routes from Missouri to Roanoke?
Most travelers choose Lambert-St Louis - Roanoke, Kansas City - Roanoke or Columbia Regional - Roanoke when deciding on the best route from Missouri to Roanoke.
Can I find deals for flights from Missouri to Roanoke that include hotel bookings?
Yes. In addition to deals on Missouri to Roanoke flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Missouri to Roanoke?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Roanoke.
Can I find deals for business class flights from Missouri to Roanoke?
Yes. Cheapflights offers flight deals from Missouri to Roanoke by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Missouri to Roanoke?
Currently, May is the cheapest month in which you can book a flight from Missouri to Roanoke (average of $210). Flying from Missouri to Roanoke in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Radford

Salem

Blacksburg

Christiansburg

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Top 3 airlines flying from Missouri to Roanoke

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$224	Average$364	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$248	Average$306	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$258	Average$453	FlexibilityNo cancel fee	On-time69%

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$200+ Cheap flights from Missouri to Roanoke (ROA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/17. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Missouri to Roanoke with Cheapflights

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Cheap flight deals from Missouri to Roanoke

Cheapest flights from Missouri to RoanokeExplore the most affordable flight options available from Missouri to Roanoke. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 21, 2025.

Explore the most affordable flight options available from Missouri to Roanoke. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 21, 2025.

Find flight deals from Missouri to Roanoke

Keep the following information in mind while searching for Missouri to Roanoke flight deals. Data was last updated December 21, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

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Use the filters below to find and compare flights from Missouri to Roanoke that are best for you.

Best time to book a flight from Missouri to Roanoke

Have a flexible travel schedule? Discover the best time to fly to Roanoke from Missouri with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Roanoke

What is the cheapest month to book a flight from Missouri to Roanoke?

What is the cheapest time of day to fly from MO to ROA?

Find hourly flight availability from Missouri to Roanoke. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 21, 2025.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Roanoke. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Roanoke from Missouri?

How long is the flight from Missouri to Roanoke?

What are the most popular routes from Missouri to Roanoke?

Can I find deals for flights from Missouri to Roanoke that include hotel bookings?

How can I find direct flights from Missouri to Roanoke?

Can I find deals for business class flights from Missouri to Roanoke?

What is the cheapest month to book a flight from Missouri to Roanoke?

Traveling to a place near Roanoke?

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Alternative routes for Missouri to Roanoke

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Top 3 airlines flying from Missouri to Roanoke

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Cheapest flights from Missouri to Roanoke
Explore the most affordable flight options available from Missouri to Roanoke. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 21, 2025.