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Roanoke

$140+ Cheap flights from Missouri to Roanoke (ROA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/6. Fares are subject to change and may not be available on all flights or dates of travel.
STL — ROA
oct. 17 — oct. 241
vie. 10/17
vie. 10/24
1 adult, Economy
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Cheap flight deals from Missouri to Roanoke

Keep the following information in mind while searching for Missouri to Roanoke flight deals. Data was last updated septiembre 17, 2025.

Round-trip from

$249
(Delta)

One-way from

$140
(Kiwi.com)

Popular in

January

Cheapest in

February

Average price

$318
From Missouri to Roanoke
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One-way flight from Missouri to Roanoke
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Highest demand for flights based on searches. 29% potential increase in price ($175 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($33 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Missouri to Roanoke

Cheapest flights from Missouri to Roanoke
Explore the most affordable flight options available from Missouri to Roanoke. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 17, 2025.

This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/141:35 pmSTL - ROA
1 stop8h 10mDelta
mar. 10/217:05 amROA - STL
1 stop6h 30mDelta
Deal found 9/16$249
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/111:37 pmMCI - ROA
1 stop4h 34mDelta
sáb. 10/187:59 pmROA - MCI
1 stop4h 53mDelta
Deal found 9/15$249
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/303:23 pmSTL - ROA
1 stop5h 18mUnited Airlines
sáb. 10/45:40 pmROA - STL
1 stop5h 55mUnited Airlines
Deal found 9/14$259
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/263:43 pmSTL - ROA
1 stop7h 16mAmerican Airlines
vie. 11/286:00 pmROA - STL
1 stop6h 04mAmerican Airlines
Deal found 9/14$279
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/176:47 pmMCI - ROA
1 stop4h 22mDelta
lun. 10/207:59 pmROA - MCI
1 stop4h 53mDelta
Deal found 9/16$279
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/225:38 pmMCI - ROA
1 stop4h 27mAmerican Airlines
vie. 10/317:30 amROA - MCI
1 stop7h 45mAmerican Airlines
Deal found 9/16$293
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/185:47 pmMCI - ROA
1 stop4h 37mUnited Airlines
sáb. 10/2510:30 amROA - MCI
2 stops11h 39mUnited Airlines
Deal found 9/15$324
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/303:23 pmMCI - ROA
2 stops7h 01mUnited Airlines
sáb. 10/410:52 amROA - MCI
1 stop4h 28mUnited Airlines
Deal found 9/15$334
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/187:00 amMCI - ROA
2 stops7h 45mAmerican Airlines
sáb. 10/256:20 pmROA - MCI
1 stop6h 49mAmerican Airlines
Deal found 9/17$353
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/273:23 pmMCI - ROA
1 stop5h 18mUnited Airlines
sáb. 10/410:30 amROA - MCI
1 stop5h 18mUnited Airlines
Deal found 9/15$354
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/165:00 amSTL - ROA
1 stop4h 17mUnited Airlines
dom. 10/196:45 amROA - STL
1 stop5h 04mUnited Airlines
Deal found 9/15$364
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/245:56 pmSTL - ROA
1 stop3h 58mAmerican Airlines
lun. 12/15:05 amROA - STL
1 stop4h 22mAmerican Airlines
Deal found 9/15$375

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
Use the filters below to find and compare flights from Missouri to Roanoke that are best for you.

Fly from

Missouri

Fly to

Roanoke

Route

Depart

Return

Price

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

mar. 10/14

1:35 pm-10:45 pm

1 stop8h 10m

Roanoke

mar. 10/21

7:05 am-12:35 pm

1 stop6h 30m

$249

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

sáb. 10/11

1:37 pm-7:11 pm

1 stop4h 34m

Roanoke

sáb. 10/18

7:59 pm-11:52 pm

1 stop4h 53m

$249

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

mar. 9/30

6:00 am-2:36 pm

1 stop7h 36m

Roanoke

sáb. 10/4

6:00 am-9:16 am

1 stop4h 16m

$259

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

mar. 9/30

3:23 pm-9:41 pm

1 stop5h 18m

Roanoke

sáb. 10/4

5:40 pm-10:35 pm

1 stop5h 55m

$259

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

mié. 11/26

3:43 pm-11:59 pm

1 stop7h 16m

Roanoke

vie. 11/28

6:00 pm-11:04 pm

1 stop6h 04m

$279

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

vie. 10/17

6:47 pm-12:09 am

1 stop4h 22m

Roanoke

lun. 10/20

7:59 pm-11:52 pm

1 stop4h 53m

$279

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

mié. 10/22

5:38 pm-11:05 pm

1 stop4h 27m

Roanoke

vie. 10/31

7:30 am-2:15 pm

1 stop7h 45m

$293

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

sáb. 10/18

5:47 pm-11:24 pm

1 stop4h 37m

Roanoke

sáb. 10/25

10:30 am-9:09 pm

2 stops11h 39m

$324

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

mar. 9/30

3:23 pm-9:41 pm

1 stop5h 18m

Roanoke

sáb. 10/4

10:52 am-2:20 pm

1 stop4h 28m

$329

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

sáb. 10/18

7:00 am-3:45 pm

2 stops7h 45m

Roanoke

sáb. 10/25

6:20 pm-12:09 am

1 stop6h 49m

$353

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 35 results
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Best time to book a flight from Missouri to Roanoke

Have a flexible travel schedule? Discover the best time to fly to Roanoke from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Roanoke

What is the cheapest month to book a flight from Missouri to Roanoke?

Currently, January is the cheapest month in which you can book a flight from Missouri to Roanoke (average of $338). Flying from Missouri to Roanoke in December is currently the most expensive (average of $475). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to ROA?

Find hourly flight availability from Missouri to Roanoke. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Roanoke as you normally would.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Roanoke. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Roanoke from Missouri?

    Roanoke (ROA), located 4.2 mi from the city center, is the airport you fly into when you book flights from Missouri to Roanoke.

  • How long is the flight from Missouri to Roanoke?

    There are many flights that can get you from Missouri to Roanoke in 5h 18m. Fly via Delta, American Airlines, or United Airlines to get the fastest option. The distance between Missouri and Roanoke is about 574 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Missouri to Roanoke one-way?

    For one-way options, check prices for Delta. According to our data, you can fly for as low as $239. Users have also found prices from $274 and $468 on United Airlines and American Airlines, respectively.

  • What are the most popular routes from Missouri to Roanoke?

    Most travelers choose Kansas City - Roanoke, Columbia Regional - Roanoke or Lambert-St Louis - Roanoke when deciding on the best route from Missouri to Roanoke.

  • Can I find deals for flights from Missouri to Roanoke that include hotel bookings?

    Yes. In addition to deals on Missouri to Roanoke flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Roanoke?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Roanoke.

  • Can I find deals for business class flights from Missouri to Roanoke?

    Yes. Cheapflights offers flight deals from Missouri to Roanoke by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Roanoke?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Roanoke (average of $338). Flying from Missouri to Roanoke in December is currently the most expensive (average of $475). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Roanoke?

Book flights to Roanoke if you plan to visit one of these locations
Radford
Salem
Blacksburg
Christiansburg

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Alternative routes for Missouri to Roanoke

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Roanoke

Discover the top 3 airlines that operate flights from Missouri to Roanoke. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$238Average$347FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$321FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$258Average$473FlexibilityNo cancel feeOn-time69%

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