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Roanoke

$247+ Cheap flights from Missouri to Roanoke (ROA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/25. Fares are subject to change and may not be available on all flights or dates of travel.
STL — ROA
Mar 16 — Mar 231
Mon 3/16
Mon 3/23
1 adult, Economy
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Cheap flight deals from Missouri to Roanoke

Cheapest flights from Missouri to Roanoke
Explore the most affordable flight options available from Missouri to Roanoke. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 14, 2026.

This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:30 pm
STL
-
ROA
1 stop5h 20m
Delta
Mon 8/317:50 pm
ROA
-
STL
1 stop4h 47m
Delta
Deal found 2/12$269
This American Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:15 pm
MCI
-
ROA
1 stop4h 44m
American Airlines
Sat 4/45:00 am
ROA
-
MCI
1 stop5h 44m
American Airlines
Deal found 2/13$269
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/276:36 pm
STL
-
ROA
1 stop4h 21m
American Airlines
Tue 3/38:15 am
ROA
-
STL
1 stop5h 18m
American Airlines
Deal found 2/11$279
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/73:36 pm
MCI
-
ROA
1 stop7h 13m
Delta
Fri 8/147:50 pm
ROA
-
MCI
1 stop5h 02m
Delta
Deal found 2/11$279
This United Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/283:10 pm
COU
-
ROA
1 stop4h 39m
United Airlines
Wed 3/46:40 am
ROA
-
COU
1 stop4h 53m
United Airlines
Deal found 2/13$298
This United Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:15 am
MCI
-
ROA
2 stops6h 58m
United Airlines
Sat 4/42:55 pm
ROA
-
MCI
1 stop5h 53m
United Airlines
Deal found 2/13$300
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/205:38 pm
MCI
-
ROA
1 stop5h 19m
American Airlines
Fri 2/278:00 pm
ROA
-
MCI
1 stop4h 59m
American Airlines
Deal found 2/11$309
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:15 am
MCI
-
ROA
2 stops6h 58m
United Airlines
Sun 4/1910:34 am
ROA
-
MCI
1 stop5h 28m
United Airlines
Deal found 2/11$319
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2310:33 am
STL
-
ROA
1 stop5h 47m
American Airlines
Sun 9/275:00 am
ROA
-
STL
1 stop4h 02m
American Airlines
Deal found 2/10$324
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/255:26 pm
MCI
-
ROA
1 stop5h 23m
Delta
Sun 6/286:00 am
ROA
-
MCI
1 stop4h 31m
Delta
Deal found 2/10$329
This United Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:25 am
STL
-
ROA
1 stop4h 33m
United Airlines
Tue 11/311:00 am
ROA
-
STL
1 stop4h 18m
United Airlines
Deal found 2/12$339
This United Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/710:00 am
MCI
-
ROA
1 stop5h 56m
United Airlines
Tue 11/105:38 pm
ROA
-
MCI
1 stop4h 51m
United Airlines
Deal found 2/12$339

Find flight deals from Missouri to Roanoke

Keep the following information in mind while searching for Missouri to Roanoke flight deals. Data was last updated February 14, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$269
(United Airlines)

One-way from

$247
(American Airlines)

Popular in

November

Cheapest in

July

Average price

$269
Provider with most accurate pricing for Lambert-St Louis-Roanoke flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Roanoke flights.
Search Deals
From Missouri to Roanoke
Search Deals
One-way flight from Missouri to Roanoke
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($65 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($33 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 14, 2026.
Use the filters below to find and compare flights from Missouri to Roanoke that are best for you.

Fly from

Missouri

Fly to

Roanoke

Route

Depart

Return

Price

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

Tue 3/10

9:15 am-4:58 pm

1 stop6h 43m

Roanoke

Tue 3/17

5:35 pm-9:59 pm

1 stop5h 24m

$269

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

Tue 3/31

5:15 pm-10:59 pm

1 stop4h 44m

Roanoke

Sat 4/4

5:00 am-9:44 am

1 stop5h 44m

$269

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Fri 2/27

6:36 pm-11:57 pm

1 stop4h 21m

Roanoke

Tue 3/3

8:15 am-12:33 pm

1 stop5h 18m

$279

ColumbiaRoanoke

COU - ROA

COUROA

Columbia Regional

Sat 2/28

3:10 pm-8:49 pm

1 stop4h 39m

Roanoke

Wed 3/4

6:40 am-10:33 am

1 stop4h 53m

$298

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

Tue 3/31

6:15 am-2:13 pm

2 stops6h 58m

Roanoke

Sat 4/4

2:55 pm-7:48 pm

1 stop5h 53m

$300

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

Thu 4/16

6:15 am-2:13 pm

2 stops6h 58m

Roanoke

Sun 4/19

10:34 am-3:02 pm

1 stop5h 28m

$319

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

Thu 2/19

12:37 pm-8:07 pm

1 stop6h 30m

Roanoke

Mon 2/23

5:33 pm-9:59 pm

1 stop5h 26m

$339

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

Thu 2/19

5:06 pm-12:06 am

1 stop6h 00m

Roanoke

Mon 2/23

7:59 pm-11:40 pm

1 stop4h 41m

$354

ColumbiaRoanoke

COU - ROA

COUROA

Columbia Regional

Sat 5/30

3:16 pm-9:13 pm

1 stop4h 57m

Roanoke

Wed 6/3

5:47 pm-9:15 pm

1 stop4h 28m

$363

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Fri 4/17

4:41 pm-12:25 am

1 stop6h 44m

Roanoke

Mon 4/20

6:00 am-11:56 am

1 stop6h 56m

$404

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/12

Showing 1-10 of 27 results
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Best time to book a flight from Missouri to Roanoke

Have a flexible travel schedule? Discover the best time to fly to Roanoke from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Roanoke

What is the cheapest month to book a flight from Missouri to Roanoke?

Currently, May is the cheapest month in which you can book a flight from Missouri to Roanoke (average of $210). Flying from Missouri to Roanoke in January is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Roanoke. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Roanoke from Missouri?

    Roanoke (ROA), located 4.2 mi from the city center, is the airport you fly into when you book flights from Missouri to Roanoke.

  • How long is the flight from Missouri to Roanoke?

    There are many flights that can get you from Missouri to Roanoke in 4h 44m. Fly via United Airlines, American Airlines, or Delta to get the fastest option. The distance between Missouri and Roanoke is about 809 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Missouri to Roanoke?

    Most travelers choose Kansas City - Roanoke, Lambert-St Louis - Roanoke or Columbia Regional - Roanoke when deciding on the best route from Missouri to Roanoke.

  • Can I find deals for flights from Missouri to Roanoke that include hotel bookings?

    Yes. In addition to deals on Missouri to Roanoke flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Roanoke?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Roanoke.

  • Can I find deals for business class flights from Missouri to Roanoke?

    Yes. Cheapflights offers flight deals from Missouri to Roanoke by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Roanoke?

    Currently, May is the cheapest month in which you can book a flight from Missouri to Roanoke (average of $210). Flying from Missouri to Roanoke in January is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Roanoke?

Book flights to Roanoke if you plan to visit one of these locations
Salem
Radford
Blacksburg
Christiansburg

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Alternative routes for Missouri to Roanoke

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Roanoke

Discover the top 3 airlines that operate flights from Missouri to Roanoke. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$224Average$350FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$288FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$301Average$482FlexibilityNo cancel feeOn-time69%

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