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Roanoke

$239+ Cheap flights from Missouri to Roanoke (ROA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/26. Fares are subject to change and may not be available on all flights or dates of travel.
STL — ROA
Dec 3 — Dec 101
Wed 12/3
Wed 12/10
1 adult, Economy
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Cheap flight deals from Missouri to Roanoke

Keep the following information in mind while searching for Missouri to Roanoke flight deals. Data was last updated November 3, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(Delta)

One-way from

$239
(Delta)

Popular in

September

Cheapest in

July

Average price

$278
Provider with most accurate pricing for Lambert-St Louis-Roanoke flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Roanoke flights.
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From Missouri to Roanoke
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One-way flight from Missouri to Roanoke
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Highest demand for flights based on searches. 20% potential increase in price ($83 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Missouri to Roanoke

Cheapest flights from Missouri to Roanoke
Explore the most affordable flight options available from Missouri to Roanoke. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/45:12 pmSTL - ROA
1 stop5h 59mDelta
Sat 12/66:00 amROA - STL
1 stop5h 24mDelta
Deal found 11/3$249
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:12 pmMCI - ROA
1 stop5h 59mDelta
Sat 1/106:00 amROA - MCI
1 stop7h 42mDelta
Deal found 11/2$249
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/253:25 pmMCI - ROA
1 stop4h 43mUnited Airlines
Fri 11/286:45 amROA - MCI
1 stop4h 55mUnited Airlines
Deal found 11/3$268
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/256:36 pmMCI - ROA
1 stop4h 29mAmerican Airlines
Fri 11/287:02 amROA - MCI
1 stop4h 54mAmerican Airlines
Deal found 11/3$274
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:53 pmSTL - ROA
1 stop4h 10mAmerican Airlines
Sat 12/62:17 pmROA - STL
2 stops8h 11mAmerican Airlines
Deal found 11/3$298
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/188:13 amSTL - ROA
1 stop4h 21mAmerican Airlines
Sat 11/228:06 pmROA - STL
1 stop4h 59mAmerican Airlines
Deal found 11/3$309
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:00 amMCI - ROA
2 stops7h 09mUnited Airlines
Sat 1/1010:15 amROA - MCI
1 stop5h 55mUnited Airlines
Deal found 11/2$333
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/153:02 pmCOU - ROA
1 stop5h 06mUnited Airlines
Tue 11/185:38 pmROA - COU
1 stop4h 41mUnited Airlines
Deal found 11/1$338
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:15 pmSTL - ROA
1 stop5h 54mDelta
Sun 11/96:00 amROA - STL
1 stop5h 43mDelta
Deal found 11/2$354
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/185:00 pmMCI - ROA
1 stop5h 53mAmerican Airlines
Sat 11/228:06 pmROA - MCI
1 stop5h 24mAmerican Airlines
Deal found 11/3$357
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/156:37 amMCI - ROA
1 stop4h 50mAmerican Airlines
Sat 11/228:06 pmROA - MCI
1 stop5h 24mAmerican Airlines
Deal found 11/2$387
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/213:41 pmMCI - ROA
1 stop7h 12mAmerican Airlines
Sun 11/238:06 pmROA - MCI
1 stop4h 56mAmerican Airlines
Deal found 11/3$439

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Missouri to Roanoke that are best for you.

Fly from

Missouri

Fly to

Roanoke

Route

Depart

Return

Price

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Thu 12/4

7:02 pm-12:11 am

1 stop4h 09m

Roanoke

Sun 12/7

8:00 pm-11:42 pm

1 stop4h 42m

$249

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Thu 12/4

7:02 pm-12:11 am

1 stop4h 09m

Roanoke

Sat 12/6

6:00 am-10:24 am

1 stop5h 24m

$249

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Tue 4/28

7:05 pm-11:49 pm

1 stop3h 44m

Roanoke

Tue 5/5

7:00 am-11:54 am

1 stop5h 54m

$249

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

Fri 12/12

5:12 pm-12:11 am

1 stop5h 59m

Roanoke

Sat 1/10

6:00 am-12:42 pm

1 stop7h 42m

$249

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

Tue 11/25

3:25 pm-9:08 pm

1 stop4h 43m

Roanoke

Fri 11/28

6:45 am-10:40 am

1 stop4h 55m

$268

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

Tue 11/25

6:36 pm-12:05 am

1 stop4h 29m

Roanoke

Fri 11/28

7:02 am-10:56 am

1 stop4h 54m

$274

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

Sat 2/28

1:23 pm-7:18 pm

1 stop4h 55m

Roanoke

Tue 3/3

7:59 pm-11:56 pm

1 stop4h 57m

$274

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Thu 12/4

6:53 pm-12:03 am

1 stop4h 10m

Roanoke

Sat 12/6

2:17 pm-9:28 pm

2 stops8h 11m

$298

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

Sat 2/28

8:00 am-8:07 pm

2 stops11h 07m

Roanoke

Tue 3/3

6:45 am-10:36 am

1 stop4h 51m

$324

Kansas CityRoanoke

MCI - ROA

MCIROA

Kansas City

Fri 12/12

6:00 am-2:09 pm

2 stops7h 09m

Roanoke

Sat 1/10

10:15 am-3:10 pm

1 stop5h 55m

$333

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/3

Showing 1-10 of 19 results
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Best time to book a flight from Missouri to Roanoke

Have a flexible travel schedule? Discover the best time to fly to Roanoke from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Roanoke

What is the cheapest month to book a flight from Missouri to Roanoke?

Currently, May is the cheapest month in which you can book a flight from Missouri to Roanoke (average of $210). Flying from Missouri to Roanoke in December is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to ROA?

Find hourly flight availability from Missouri to Roanoke. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 3, 2025.

A simple way to save on the total cost of your ticket is to fly from Missouri to Roanoke in the evening. If you’re flexible enough to do this you can expect to save up to 42% on your trip compared to booking a flight in the afternoon.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Roanoke. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Roanoke from Missouri?

    Roanoke (ROA), located 4.2 mi from the city center, is the airport you fly into when you book flights from Missouri to Roanoke.

  • How long is the flight from Missouri to Roanoke?

    There are many flights that can get you from Missouri to Roanoke in 4h 09m. Fly via Delta, United Airlines, or American Airlines to get the fastest option. The distance between Missouri and Roanoke is about 574 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Missouri to Roanoke one-way?

    For one-way options, check prices for Delta. According to our data, you can fly for as low as $239. Users have also found prices from $451 and $531 on United Airlines and American Airlines, respectively.

  • What are the most popular routes from Missouri to Roanoke?

    Most travelers choose Lambert-St Louis - Roanoke, Kansas City - Roanoke or Columbia Regional - Roanoke when deciding on the best route from Missouri to Roanoke.

  • Can I find deals for flights from Missouri to Roanoke that include hotel bookings?

    Yes. In addition to deals on Missouri to Roanoke flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Roanoke?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Roanoke.

  • Can I find deals for business class flights from Missouri to Roanoke?

    Yes. Cheapflights offers flight deals from Missouri to Roanoke by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Roanoke?

    Currently, May is the cheapest month in which you can book a flight from Missouri to Roanoke (average of $210). Flying from Missouri to Roanoke in December is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Roanoke?

Book flights to Roanoke if you plan to visit one of these locations
Radford
Salem
Blacksburg
Christiansburg

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Alternative routes for Missouri to Roanoke

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Roanoke

Discover the top 3 airlines that operate flights from Missouri to Roanoke. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$224Average$363FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$310FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$258Average$482FlexibilityNo cancel feeOn-time69%

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