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Roanoke

$173+ Cheap flights from Mississippi to Roanoke (ROA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — ROA
Mar 19 — Mar 261
Thu 3/19
Thu 3/26
1 adult, Economy
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Cheap flight deals from Mississippi to Roanoke

Cheapest flights from Mississippi to Roanoke
Explore the most affordable flight options available from Mississippi to Roanoke. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 17, 2026.

This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/224:55 pm
MEM
-
ROA
1 stop5h 54m
Delta
Sun 7/266:00 am
ROA
-
MEM
1 stop4h 35m
Delta
Deal found 2/16$301
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:30 am
MEM
-
ROA
1 stop4h 05m
Delta
Mon 7/276:00 am
ROA
-
MEM
1 stop4h 35m
Delta
Deal found 2/16$319
This United Airlines deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/73:00 pm
MEM
-
ROA
1 stop4h 39m
United Airlines
Tue 11/105:38 pm
ROA
-
MEM
1 stop5h 15m
United Airlines
Deal found 2/14$339
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:30 am
MEM
-
ROA
1 stop4h 05m
Delta
Sun 7/126:00 am
ROA
-
MEM
1 stop4h 35m
Delta
Deal found 2/16$370
This United Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/287:30 am
MEM
-
ROA
2 stops11h 37m
United Airlines
Wed 3/46:40 am
ROA
-
MEM
1 stop5h 17m
United Airlines
Deal found 2/13$371
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/227:05 am
MEM
-
ROA
2 stops9h 06m
American Airlines
Tue 7/286:02 pm
ROA
-
MEM
1 stop6h 50m
American Airlines
Deal found 2/16$376
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:30 am
MEM
-
ROA
1 stop15h 23m
Delta
Tue 7/286:00 am
ROA
-
MEM
1 stop4h 35m
Delta
Deal found 2/16$384
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/36:00 am
MEM
-
ROA
1 stop4h 34m
American Airlines
Sat 3/78:00 pm
ROA
-
MEM
1 stop4h 51m
American Airlines
Deal found 2/16$400
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:10 am
MEM
-
ROA
2 stops11h 01m
American Airlines
Sun 7/268:02 pm
ROA
-
MEM
1 stop4h 50m
American Airlines
Deal found 2/16$451
This American Airlines deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:39 pm
JAN
-
ROA
1 stop4h 00m
American Airlines
Sat 5/167:45 pm
ROA
-
JAN
1 stop5h 14m
American Airlines
Deal found 2/14$558
This United Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:00 am
JAN
-
ROA
2 stops15h 23m
United Airlines
Tue 11/102:13 pm
ROA
-
JAN
2 stops22h 00m
United Airlines
Deal found 2/15$689
This American Airlines deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:39 pm
JAN
-
ROA
1 stop4h 00m
American Airlines
Fri 5/158:00 pm
ROA
-
JAN
1 stop4h 59m
American Airlines
Deal found 2/14$721

Find flight deals from Mississippi to Roanoke

Keep the following information in mind while searching for Mississippi to Roanoke flight deals. Data was last updated February 17, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$370
(Delta)

One-way from

$173
(Kiwi.com)
Provider with most accurate pricing for Jackson-Evers Intl-Roanoke flight deals.
Search Deals
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Roanoke flights.
Search Deals
From Mississippi to Roanoke
Search Deals
One-way flight from Mississippi to Roanoke
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 17, 2026.
Use the filters below to find and compare flights from Mississippi to Roanoke that are best for you.

Fly from

Mississippi

Fly to

Roanoke

Route

Depart

Return

Price

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Wed 7/22

4:55 pm-11:49 pm

1 stop5h 54m

Roanoke

Sun 7/26

6:00 am-9:35 am

1 stop4h 35m

$301

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Fri 7/24

5:55 pm-11:49 pm

1 stop4h 54m

Roanoke

Tue 7/28

6:00 am-9:35 am

1 stop4h 35m

$301

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Wed 7/22

5:30 am-10:35 am

1 stop4h 05m

Roanoke

Tue 7/28

6:00 am-9:35 am

1 stop4h 35m

$319

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Wed 7/22

5:30 am-10:35 am

1 stop4h 05m

Roanoke

Mon 7/27

6:00 am-9:35 am

1 stop4h 35m

$319

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Thu 7/9

5:30 am-10:35 am

1 stop4h 05m

Roanoke

Sun 7/12

6:00 am-9:35 am

1 stop4h 35m

$370

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Thu 7/23

5:55 pm-11:49 pm

1 stop4h 54m

Roanoke

Mon 7/27

6:00 am-9:35 am

1 stop4h 35m

$370

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Sat 2/28

7:30 am-8:07 pm

2 stops11h 37m

Roanoke

Wed 3/4

6:40 am-10:57 am

1 stop5h 17m

$371

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Wed 7/22

7:05 am-5:11 pm

2 stops9h 06m

Roanoke

Tue 7/28

6:02 pm-11:52 pm

1 stop6h 50m

$376

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Fri 7/24

5:30 pm-1:24 pm

1 stop18h 54m

Roanoke

Mon 7/27

6:00 am-9:35 am

1 stop4h 35m

$384

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Thu 7/23

6:30 am-10:53 pm

1 stop15h 23m

Roanoke

Tue 7/28

6:00 am-9:35 am

1 stop4h 35m

$384

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/16

Showing 1-10 of 22 results
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Best time to book a flight from Mississippi to Roanoke

Have a flexible travel schedule? Discover the best time to fly to Roanoke from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Roanoke
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Roanoke. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Roanoke from Mississippi?

    Roanoke (ROA), located 4.2 mi from the city center, is the airport you fly into when you book flights from Mississippi to Roanoke.

  • How long is the flight from Mississippi to Roanoke?

    Delta, American Airlines, and United Airlines can get you from Mississippi to Roanoke in just under 4h. Your travel time can differ by up to 12h 02m. Airlines will cover a distance of 669 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Mississippi to Roanoke that include hotel bookings?

    Yes. In addition to deals on Mississippi to Roanoke flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Roanoke?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Roanoke.

  • Can I find deals for business class flights from Mississippi to Roanoke?

    Yes. Cheapflights offers flight deals from Mississippi to Roanoke by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Roanoke?

Book flights to Roanoke if you plan to visit one of these locations
Salem
Radford
Blacksburg
Christiansburg

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Alternative routes for Mississippi to Roanoke

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