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Roanoke

$228+ Cheap flights from Mississippi to Roanoke (ROA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/13. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — ROA
Feb 15 — Feb 221
Sun 2/15
Sun 2/22
1 adult, Economy
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Cheap flight deals from Mississippi to Roanoke

Keep the following information in mind while searching for Mississippi to Roanoke flight deals. Data was last updated January 16, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$269
(Delta)

One-way from

$228
(Kiwi.com)
Provider with most accurate pricing for Jackson-Evers Intl-Roanoke flight deals.
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Provider most trusted by Cheapflights users for Jackson-Evers Intl-Roanoke flights.
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From Mississippi to Roanoke
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One-way flight from Mississippi to Roanoke
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Find flight deals from Mississippi to Roanoke

Cheapest flights from Mississippi to Roanoke
Explore the most affordable flight options available from Mississippi to Roanoke. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 16, 2026.

This Delta deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:55 pm
MEM
-
ROA
1 stop4h 54m
Delta
Wed 6/246:00 am
ROA
-
MEM
1 stop4h 35m
Delta
Deal found 1/15$269
This Delta deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/1412:19 pm
JAN
-
ROA
1 stop5h 55m
Delta
Sat 2/217:59 pm
ROA
-
JAN
1 stop4h 08m
Delta
Deal found 1/15$269
This Delta deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/305:22 pm
MEM
-
ROA
1 stop5h 42m
Delta
Sun 2/17:59 pm
ROA
-
MEM
1 stop4h 14m
Delta
Deal found 1/15$279
This Delta deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/289:31 am
MEM
-
ROA
1 stop4h 36m
Delta
Wed 2/46:00 am
ROA
-
MEM
1 stop5h 52m
Delta
Deal found 1/15$309
This United Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/317:30 am
MEM
-
ROA
2 stops11h 01m
United Airlines
Sun 2/16:45 am
ROA
-
MEM
1 stop5h 09m
United Airlines
Deal found 1/15$335
This United Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1711:19 am
MEM
-
ROA
2 stops11h 04m
United Airlines
Wed 6/2411:00 am
ROA
-
MEM
1 stop7h 23m
United Airlines
Deal found 1/15$344
This United Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/297:30 am
MEM
-
ROA
1 stop6h 16m
United Airlines
Wed 2/410:15 am
ROA
-
MEM
2 stops8h 11m
United Airlines
Deal found 1/15$354
This Delta deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/156:59 pm
JAN
-
ROA
1 stop4h 05m
Delta
Sun 1/184:35 pm
ROA
-
JAN
1 stop4h 01m
Delta
Deal found 1/15$369
This United Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/307:30 am
MEM
-
ROA
1 stop6h 16m
United Airlines
Sun 2/12:55 pm
ROA
-
MEM
2 stops8h 04m
United Airlines
Deal found 1/15$373
This United Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/319:55 am
MEM
-
ROA
1 stop6h 08m
United Airlines
Mon 2/22:55 pm
ROA
-
MEM
2 stops8h 04m
United Airlines
Deal found 1/15$380
This United Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/289:55 am
MEM
-
ROA
2 stops8h 36m
United Airlines
Mon 2/23:39 pm
ROA
-
MEM
1 stop7h 20m
United Airlines
Deal found 1/15$384
This United Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/289:55 am
MEM
-
ROA
2 stops8h 36m
United Airlines
Wed 2/410:15 am
ROA
-
MEM
2 stops8h 11m
United Airlines
Deal found 1/15$390

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 16, 2026.
Use the filters below to find and compare flights from Mississippi to Roanoke that are best for you.

Fly from

Mississippi

Fly to

Roanoke

Route

Depart

Return

Price

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Wed 6/17

5:55 pm-11:49 pm

1 stop4h 54m

Roanoke

Wed 6/24

6:00 am-9:35 am

1 stop4h 35m

$269

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Fri 6/19

5:55 pm-11:49 pm

1 stop4h 54m

Roanoke

Thu 6/25

6:00 am-9:35 am

1 stop4h 35m

$269

JacksonRoanoke

JAN - ROA

JANROA

Jackson-Evers Intl

Sat 2/14

12:19 pm-7:14 pm

1 stop5h 55m

Roanoke

Sat 2/21

7:59 pm-11:07 pm

1 stop4h 08m

$269

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Fri 1/30

5:22 pm-12:04 am

1 stop5h 42m

Roanoke

Sun 2/1

7:59 pm-11:13 pm

1 stop4h 14m

$279

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Fri 1/30

5:22 pm-12:04 am

1 stop5h 42m

Roanoke

Tue 2/3

7:59 pm-11:13 pm

1 stop4h 14m

$279

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Thu 1/29

6:55 pm-12:04 am

1 stop4h 09m

Roanoke

Mon 2/2

7:59 pm-11:13 pm

1 stop4h 14m

$279

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Fri 1/30

6:55 pm-12:04 am

1 stop4h 09m

Roanoke

Wed 2/4

3:49 pm-7:28 pm

1 stop4h 39m

$279

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Sat 1/31

5:22 pm-12:04 am

1 stop5h 42m

Roanoke

Sun 2/1

7:59 pm-11:13 pm

1 stop4h 14m

$279

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Wed 1/28

5:22 pm-12:04 am

1 stop5h 42m

Roanoke

Tue 2/3

11:24 am-4:16 pm

1 stop5h 52m

$309

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Wed 1/28

11:57 am-7:19 pm

1 stop6h 22m

Roanoke

Sat 1/31

11:24 am-3:02 pm

1 stop4h 38m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/15

Showing 1-10 of 23 results
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Best time to book a flight from Mississippi to Roanoke

Have a flexible travel schedule? Discover the best time to fly to Roanoke from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Roanoke
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Roanoke. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Roanoke from Mississippi?

    Roanoke (ROA), located 4.2 mi from the city center, is the airport you fly into when you book flights from Mississippi to Roanoke.

  • How long is the flight from Mississippi to Roanoke?

    Delta and American Airlines can get you from Mississippi to Roanoke in just under 4h 54m. Your travel time can differ by up to . Airlines will cover a distance of 579 mi.

  • Can I find deals for flights from Mississippi to Roanoke that include hotel bookings?

    Yes. In addition to deals on Mississippi to Roanoke flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Roanoke?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Roanoke.

  • Can I find deals for business class flights from Mississippi to Roanoke?

    Yes. Cheapflights offers flight deals from Mississippi to Roanoke by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Roanoke?

Book flights to Roanoke if you plan to visit one of these locations
Radford
Salem
Blacksburg
Christiansburg

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Alternative routes for Mississippi to Roanoke

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