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Roanoke

$105+ Cheap flights from Mississippi to Roanoke (ROA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/23. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — ROA
Dec 20 — Dec 271
Sat 12/20
Sat 12/27
1 adult, Economy
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Find flight deals from Mississippi to Roanoke

Cheapest flights from Mississippi to Roanoke
Explore the most affordable flight options available from Mississippi to Roanoke. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 20, 2025.

This Delta deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/172:32 pmMEM - ROA
1 stop3h 43mDelta
Sat 12/207:03 pmROA - MEM
1 stop5h 08mDelta
Deal found 11/18$264
This Delta deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:00 amMEM - ROA
1 stop3h 40mDelta
Sun 12/76:00 amROA - MEM
1 stop4h 27mDelta
Deal found 11/18$279
This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/310:29 amMEM - ROA
2 stops9h 01mAmerican Airlines
Sun 12/78:10 pmROA - MEM
1 stop4h 54mAmerican Airlines
Deal found 11/18$284
This Delta deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/256:00 amMEM - ROA
1 stop3h 40mDelta
Sun 12/76:00 amROA - MEM
1 stop6h 42mDelta
Deal found 11/20$324
This American Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/259:23 amMEM - ROA
2 stops7h 11mAmerican Airlines
Sun 12/78:10 pmROA - MEM
1 stop4h 54mAmerican Airlines
Deal found 11/20$329
This United Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/47:39 amMEM - ROA
2 stops10h 17mUnited Airlines
Mon 12/82:55 pmROA - MEM
2 stops9h 44mUnited Airlines
Deal found 11/19$349
This United Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/57:39 amMEM - ROA
2 stops10h 17mUnited Airlines
Mon 12/82:55 pmROA - MEM
2 stops8h 04mUnited Airlines
Deal found 11/19$364
This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/227:02 amMEM - ROA
1 stop6h 18mAmerican Airlines
Mon 11/249:01 amROA - MEM
1 stop6h 45mAmerican Airlines
Deal found 11/18$369
This United Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2210:30 amMEM - ROA
1 stop5h 26mUnited Airlines
Mon 11/246:20 amROA - MEM
2 stops10h 13mUnited Airlines
Deal found 11/18$374
This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1710:29 amMEM - ROA
2 stops9h 01mAmerican Airlines
Sat 12/207:07 pmROA - MEM
1 stop5h 49mAmerican Airlines
Deal found 11/18$398
This United Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/37:39 amMEM - ROA
3 stops10h 17mUnited Airlines
Sun 12/75:40 pmROA - MEM
1 stop5h 19mUnited Airlines
Deal found 11/18$419
This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/176:44 amJAN - ROA
2 stops8h 40mAmerican Airlines
Tue 12/236:00 amROA - JAN
1 stop7h 31mAmerican Airlines
Deal found 11/18$494

Cheap flight deals from Mississippi to Roanoke

Keep the following information in mind while searching for Mississippi to Roanoke flight deals. Data was last updated November 20, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(Delta)

One-way from

$105
(Kiwi.com)

Popular in

October

Cheapest in

May

Average price

$520
Provider with most accurate pricing for Jackson-Evers Intl-Roanoke flight deals.
Search Deals
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Roanoke flights.
Search Deals
From Mississippi to Roanoke
Search Deals
One-way flight from Mississippi to Roanoke
Search Deals
Highest demand for flights based on searches. 34% potential increase in price ($188 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($36 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 20, 2025.
Use the filters below to find and compare flights from Mississippi to Roanoke that are best for you.

Fly from

Mississippi

Fly to

Roanoke

Route

Depart

Return

Price

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Fri 2/20

7:10 pm-12:10 am

1 stop4h 00m

Roanoke

Mon 3/2

7:59 pm-11:19 pm

1 stop4h 20m

$249

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Wed 1/28

11:57 am-7:19 pm

1 stop6h 22m

Roanoke

Sat 1/31

5:25 pm-11:13 pm

1 stop6h 48m

$249

JacksonRoanoke

JAN - ROA

JANROA

Jackson-Evers Intl

Sat 1/31

5:32 am-10:44 am

1 stop4h 12m

Roanoke

Tue 2/3

7:59 pm-11:01 pm

1 stop4h 02m

$249

JacksonRoanoke

JAN - ROA

JANROA

Jackson-Evers Intl

Wed 2/18

9:28 am-2:49 pm

1 stop4h 21m

Roanoke

Sat 2/21

7:59 pm-11:13 pm

1 stop4h 14m

$249

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Fri 2/20

8:56 am-5:36 pm

2 stops7h 40m

Roanoke

Mon 3/2

8:00 pm-11:55 pm

1 stop4h 55m

$254

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Wed 12/17

2:32 pm-7:15 pm

1 stop3h 43m

Roanoke

Sat 12/20

7:03 pm-11:11 pm

1 stop5h 08m

$264

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Thu 12/4

7:21 pm-12:11 am

1 stop3h 50m

Roanoke

Mon 12/8

6:00 am-9:27 am

1 stop4h 27m

$279

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Wed 12/3

6:00 am-10:40 am

1 stop3h 40m

Roanoke

Sun 12/7

6:00 am-9:27 am

1 stop4h 27m

$279

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Fri 12/5

6:00 am-10:40 am

1 stop3h 40m

Roanoke

Mon 12/8

8:00 pm-11:23 pm

1 stop4h 23m

$279

MemphisRoanoke

MEM - ROA

MEMROA

Memphis

Wed 12/3

10:29 am-8:30 pm

2 stops9h 01m

Roanoke

Sun 12/7

8:10 pm-12:04 am

1 stop4h 54m

$284

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/18

Showing 1-10 of 27 results
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Best time to book a flight from Mississippi to Roanoke

Have a flexible travel schedule? Discover the best time to fly to Roanoke from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Roanoke

What is the cheapest month to book a flight from Mississippi to Roanoke?

Currently, May is the cheapest month in which you can book a flight from Mississippi to Roanoke (average of $149). Flying from Mississippi to Roanoke in April is currently the most expensive (average of $435). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS to ROA?

Find hourly flight availability from Mississippi to Roanoke. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 20, 2025.

It’s optimal to fly from Mississippi to Roanoke in the evening. By choosing this option you can save up to 27% on the cost of your flight, compared to a flight in the morning.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Roanoke. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Roanoke from Mississippi?

    Roanoke (ROA), located 4.2 mi from the city center, is the airport you fly into when you book flights from Mississippi to Roanoke.

  • How long is the flight from Mississippi to Roanoke?

    Delta and American Airlines can get you from Mississippi to Roanoke in just under 4h. Your travel time can differ by up to 3h 40m. Airlines will cover a distance of 579 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Mississippi to Roanoke that include hotel bookings?

    Yes. In addition to deals on Mississippi to Roanoke flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Roanoke?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Roanoke.

  • Can I find deals for business class flights from Mississippi to Roanoke?

    Yes. Cheapflights offers flight deals from Mississippi to Roanoke by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Roanoke?

    Currently, May is the cheapest month in which you can book a flight from Mississippi to Roanoke (average of $149). Flying from Mississippi to Roanoke in April is currently the most expensive (average of $435). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Roanoke?

Book flights to Roanoke if you plan to visit one of these locations
Radford
Salem
Blacksburg
Christiansburg

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