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Roanoke

$249+ Cheap flights from Des Moines to Roanoke (DSM - ROA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/29. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ROA
Mar 18 — Mar 251
Wed 3/18
Wed 3/25
1 adult, Economy
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Cheap flight deals from Des Moines to Roanoke

Cheapest flights from Des Moines to Roanoke
Explore the most affordable flight options available from Des Moines to Roanoke. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 16, 2026.

This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:20 pm
DSM
-
ROA
1 stop5h 44m
Delta
Tue 4/146:00 am
ROA
-
DSM
1 stop6h 05m
Delta
Deal found 2/12$269
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/74:25 pm
DSM
-
ROA
2 stops6h 39m
Delta
Wed 4/156:00 am
ROA
-
DSM
1 stop6h 05m
Delta
Deal found 2/12$274
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/275:15 pm
DSM
-
ROA
1 stop5h 51m
Delta
Tue 3/36:00 am
ROA
-
DSM
1 stop6h 19m
Delta
Deal found 2/12$279
This United Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:00 am
DSM
-
ROA
1 stop6h 33m
United Airlines
Sat 8/85:47 pm
ROA
-
DSM
1 stop4h 25m
United Airlines
Deal found 2/13$281
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:20 pm
DSM
-
ROA
1 stop5h 44m
Delta
Sat 4/116:00 am
ROA
-
DSM
1 stop5h 48m
Delta
Deal found 2/12$304
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/276:00 am
DSM
-
ROA
2 stops9h 33m
American Airlines
Tue 3/37:33 am
ROA
-
DSM
1 stop6h 31m
American Airlines
Deal found 2/12$305
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/84:25 pm
DSM
-
ROA
2 stops6h 39m
Delta
Wed 4/156:00 am
ROA
-
DSM
1 stop6h 05m
Delta
Deal found 2/12$309
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/82:02 pm
DSM
-
ROA
1 stop6h 24m
American Airlines
Sat 4/117:28 am
ROA
-
DSM
1 stop7h 18m
American Airlines
Deal found 2/12$339
This United Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:05 pm
DSM
-
ROA
2 stops9h 18m
United Airlines
Tue 11/107:00 am
ROA
-
DSM
1 stop6h 30m
United Airlines
Deal found 2/12$344
This United Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:20 am
DSM
-
ROA
2 stops6h 53m
United Airlines
Tue 4/142:04 pm
ROA
-
DSM
2 stops10h 38m
United Airlines
Deal found 2/12$349

Find flight deals from Des Moines to Roanoke

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Roanoke (ROA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 16, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$269
(Delta)

One-way from

$249
(United Airlines)

Popular in

February

Cheapest in

June

Average price

$441
Provider with most accurate pricing for Des Moines-Roanoke flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Roanoke flights.
Search Deals
From Des Moines to Roanoke
Search Deals
One-way flight from Des Moines to Roanoke
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($40 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 16, 2026.
Use the filters below to find and compare flights from Des Moines to Roanoke that are best for you.

Fly from

Des Moines

Fly to

Roanoke

Route

Depart

Return

Price

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sat 4/11

5:20 pm-12:04 am

1 stop5h 44m

Roanoke

Wed 4/15

6:00 am-11:05 am

1 stop6h 05m

$269

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Wed 4/1

5:20 pm-12:04 am

1 stop5h 44m

Roanoke

Wed 4/8

6:00 am-10:48 am

1 stop5h 48m

$269

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Mon 4/6

5:20 pm-12:04 am

1 stop5h 44m

Roanoke

Tue 4/14

6:00 am-11:05 am

1 stop6h 05m

$269

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sat 4/11

5:20 pm-12:04 am

1 stop5h 44m

Roanoke

Tue 4/14

6:00 am-11:05 am

1 stop6h 05m

$269

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sat 5/16

6:41 pm-12:34 am

1 stop4h 53m

Roanoke

Sat 5/23

6:00 am-11:03 am

1 stop6h 03m

$269

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Mon 4/6

5:20 pm-12:04 am

1 stop5h 44m

Roanoke

Wed 4/15

6:00 am-11:05 am

1 stop6h 05m

$269

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Tue 4/7

4:25 pm-12:04 am

2 stops6h 39m

Roanoke

Wed 4/15

6:00 am-11:05 am

1 stop6h 05m

$274

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sun 3/29

1:10 pm-9:07 pm

1 stop6h 57m

$249

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sat 3/7

3:28 pm-9:08 am

1 stop16h 40m

$271

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sat 3/7

8:21 pm-3:56 pm

3 stops42h 35m

$357

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/15

Compare providers for flights from Des Moines to Roanoke

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Roanoke in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Roanoke flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Roanoke flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Roanoke flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Roanoke flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Roanoke flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Roanoke

Have a flexible travel schedule? Discover the best time to fly to Roanoke from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Roanoke

What is the cheapest month to book a flight from Des Moines to Roanoke?

Currently, May is the cheapest month in which you can book a flight from Des Moines to Roanoke (average of $248). Flying from Des Moines to Roanoke in December is currently the most expensive (average of $436). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Roanoke

Get insights into the airlines that provide service to Roanoke. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Roanoke. Reviews last updated February 16, 2026.
Read through reviews of airlines operating flights from Des Moines to Roanoke, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,206 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,206 reviews
Delta
7.9
Good
8,206 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,291 reviews
Delta
7.9
Good
8,206 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Roanoke. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Roanoke?

    Airlines like Delta fly from Des Moines to Roanoke in about 5h 44m. The time it takes to get you to your destination can typically vary by up to . There are 784 mi between Des Moines and Roanoke.

  • What are the cheapest airlines flying from Des Moines to Roanoke round-trip?

    Our cheapest airline available from Des Moines to Roanoke is American Airlines. Our recent data shows that you can find tickets from as low as $248 on this airline. An additional option worth looking into is Delta, starting at $248. American Airlines is currently priced 23% below the average price you’ll pay for this route.

  • Can I find deals for flights from Des Moines to Roanoke that include hotel bookings?

    Yes. In addition to deals on Des Moines to Roanoke flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Roanoke?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Roanoke.

  • Can I find deals for business class flights from Des Moines to Roanoke?

    Yes. Cheapflights offers flight deals from Des Moines to Roanoke by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Roanoke?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to Roanoke (average of $248). Flying from Des Moines to Roanoke in December is currently the most expensive (average of $436). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Roanoke?

Book flights to Roanoke if you plan to visit one of these locations
Salem
Radford
Blacksburg
Christiansburg

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Alternative routes for Des Moines to Roanoke

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Des Moines to Roanoke

Discover the top 2 airlines that operate flights from Des Moines to Roanoke. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 16, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$349FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$323FlexibilityNo cancel feeOn-timeN/A

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