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Portland

$168+ Cheap flights from Missouri to Portland, ME (PWM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/20. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PWM
Mar 6 — Mar 131
Fri 3/6
Fri 3/13
1 adult, Economy
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Cheap flight deals from Missouri to Portland

Cheapest flights from Missouri to Portland
Explore the most affordable flight options available from Missouri to Portland. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.

This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/258:00 am
COU
-
PWM
1 stop6h 14m
United Airlines
Tue 3/36:00 am
PWM
-
COU
2 stops9h 28m
United Airlines
Deal found 2/2$274
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/183:18 pm
SGF
-
PWM
1 stop6h 27m
American Airlines
Sat 8/222:48 pm
PWM
-
SGF
1 stop7h 50m
American Airlines
Deal found 2/4$289
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2810:04 am
SGF
-
PWM
1 stop6h 45m
American Airlines
Tue 9/13:30 pm
PWM
-
SGF
1 stop6h 23m
American Airlines
Deal found 2/1$309
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:30 am
MCI
-
PWM
1 stop4h 27m
Delta
Wed 5/201:18 pm
PWM
-
MCI
1 stop5h 36m
Delta
Deal found 2/3$313
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/285:21 pm
STL
-
PWM
1 stop5h 52m
American Airlines
Thu 5/75:51 pm
PWM
-
STL
1 stop5h 28m
American Airlines
Deal found 2/2$317
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/163:28 pm
MCI
-
PWM
1 stop6h 54m
American Airlines
Tue 4/215:51 pm
PWM
-
MCI
1 stop7h 08m
American Airlines
Deal found 2/3$332
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:15 am
COU
-
PWM
2 stops11h 05m
United Airlines
Tue 3/34:15 pm
PWM
-
COU
1 stop6h 18m
United Airlines
Deal found 2/2$334
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/212:08 pm
MCI
-
PWM
1 stop5h 15m
United Airlines
Tue 5/55:30 am
PWM
-
MCI
2 stops9h 56m
United Airlines
Deal found 2/3$337
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/178:00 am
MCI
-
PWM
1 stop6h 14m
United Airlines
Sat 2/214:15 pm
PWM
-
MCI
1 stop6h 44m
United Airlines
Deal found 2/2$339
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/168:30 am
STL
-
PWM
1 stop4h 53m
United Airlines
Fri 2/204:15 pm
PWM
-
STL
1 stop6h 25m
United Airlines
Deal found 2/2$339
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/123:10 pm
COU
-
PWM
1 stop5h 09m
United Airlines
Tue 5/194:45 pm
PWM
-
COU
1 stop6h 13m
United Airlines
Deal found 2/4$348
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:45 am
STL
-
PWM
1 stop5h 29m
United Airlines
Fri 5/84:45 pm
PWM
-
STL
1 stop5h 23m
United Airlines
Deal found 2/2$353

Find flight deals from Missouri to Portland

Keep the following information in mind while searching for Missouri to Portland flight deals. Data was last updated February 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$274
(United Airlines)

One-way from

$168
(American Airlines)

Popular in

January

Cheapest in

March

Average price

$479
Provider with most accurate pricing for Lambert-St Louis-Portland flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Portland flights.
Search Deals
From Missouri to Portland
Search Deals
One-way flight from Missouri to Portland
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($42 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Portland that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Missouri to Portland that are best for you.

Fly from

Missouri

Fly to

Portland

Route

Depart

Return

Price

ColumbiaPortland

COU - PWM

COUPWM

Columbia Regional

Wed 2/25

8:00 am-3:14 pm

1 stop6h 14m

Portland

Tue 3/3

6:00 am-2:28 pm

2 stops9h 28m

$274

Kansas CityPortland

MCI - PWM

MCIPWM

Kansas City

Tue 5/12

6:30 am-11:57 am

1 stop4h 27m

Portland

Wed 5/20

1:18 pm-5:54 pm

1 stop5h 36m

$313

St. LouisPortland

STL - PWM

STLPWM

Lambert-St Louis

Tue 4/28

5:21 pm-12:13 am

1 stop5h 52m

Portland

Thu 5/7

5:51 pm-10:19 pm

1 stop5h 28m

$317

Kansas CityPortland

MCI - PWM

MCIPWM

Kansas City

Sat 5/2

12:08 pm-6:23 pm

1 stop5h 15m

Portland

Tue 5/5

9:39 am-2:26 pm

1 stop5h 47m

$332

ColumbiaPortland

COU - PWM

COUPWM

Columbia Regional

Thu 2/26

11:15 am-11:20 pm

2 stops11h 05m

Portland

Tue 3/3

4:15 pm-9:33 pm

1 stop6h 18m

$334

Kansas CityPortland

MCI - PWM

MCIPWM

Kansas City

Tue 2/17

8:00 am-3:14 pm

1 stop6h 14m

Portland

Sat 2/21

4:15 pm-9:59 pm

1 stop6h 44m

$339

St. LouisPortland

STL - PWM

STLPWM

Lambert-St Louis

Mon 2/16

8:30 am-2:23 pm

1 stop4h 53m

Portland

Fri 2/20

4:15 pm-9:40 pm

1 stop6h 25m

$339

Kansas CityPortland

MCI - PWM

MCIPWM

Kansas City

Wed 2/18

11:32 am-11:20 pm

2 stops10h 48m

Portland

Tue 2/24

4:15 pm-9:59 pm

1 stop6h 44m

$344

St. LouisPortland

STL - PWM

STLPWM

Lambert-St Louis

Tue 2/17

6:25 am-3:14 pm

1 stop7h 49m

Portland

Sat 2/21

6:00 am-2:29 pm

2 stops9h 29m

$344

ColumbiaPortland

COU - PWM

COUPWM

Columbia Regional

Wed 5/13

8:00 am-2:14 pm

1 stop5h 14m

Portland

Tue 5/19

4:45 pm-9:58 pm

1 stop6h 13m

$348

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/4

Showing 1-10 of 39 results
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Best time to book a flight from Missouri to Portland

Have a flexible travel schedule? Discover the best time to fly to Portland from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Portland

What is the cheapest month to book a flight from Missouri to Portland, Maine?

Currently, July is the cheapest month in which you can book a flight from Missouri to Portland, Maine (average of $128). Flying from Missouri to Portland, Maine in June is currently the most expensive (average of $266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Portland. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Portland from Missouri?

    If you book a flight to Portland from Missouri, you will be flying to Portland, which is the city’s only airport. Portland (PWM) is located 2.9 mi from the center of Portland.

  • How long is the flight from Missouri to Portland, Maine?

    Airlines like United Airlines, Delta, and American Airlines fly from Missouri to Portland, Maine in about 4h 27m. The time it takes to get you to your destination can typically vary by up to 1h 47m. The distance from Missouri to Portland, Maine is about 1293 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Missouri to Portland, Maine one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $128. American Airlines flights start at $142 while deals on Southwest start at $143 one-way.

  • What are the most popular routes from Missouri to Portland, Maine?

    While some choose either Lambert-St Louis - Portland or Springfield-Branson - Portland, Kansas City - Portland is the most popular route from Missouri to Portland, Maine.

  • Can I find deals for flights from Missouri to Portland that include hotel bookings?

    Yes. In addition to deals on Missouri to Portland flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Portland?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Portland.

  • Can I find deals for business class flights from Missouri to Portland?

    Yes. Cheapflights offers flight deals from Missouri to Portland by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Portland, Maine?

    Currently, July is the cheapest month in which you can book a flight from Missouri to Portland, Maine (average of $128). Flying from Missouri to Portland, Maine in June is currently the most expensive (average of $266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Portland?

Book flights to Portland if you plan to visit one of these locations
North Conway
Brunswick
Auburn
Conway

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Alternative routes for Missouri to Portland

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Missouri to Portland

Discover the top 4 airlines that operate flights from Missouri to Portland. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$128Average$382FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$212Average$483FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$274Average$451FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$284Average$497FlexibilityNo cancel feeOn-time63%

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